Metabolite_name RefMet_name A375P 5 A375P 6 A375P 7 A375P 8 A375 VR 5 A375 VR 6 A375 VR 7 A375 VR 8 A375 VR-Rano 5 A375 VR-Rano 6 A375 VR-Rano 7 A375 VR-Rano 8 Factors - Treatment:VEHICLE Treatment:VEHICLE Treatment:VEHICLE Treatment:VEHICLE Treatment:VEMURA Treatment:VEMURA Treatment:VEMURA Treatment:VEMURA Treatment:VEMURA+RANO Treatment:VEMURA+RANO Treatment:VEMURA+RANO Treatment:VEMURA+RANO 2-Aminomuconate 2-Aminomuconic acid 214579 199964 222997 313711 38300 27043 21227 33144 40533 64678 28482 55602 3-Methyleneoxindole 3-Methyleneoxindole 282525 226850 111795 179657 77147 53130 47889 47175 68829 66531 84459 88847 5-Methylthioadenosine 5'-Methylthioadenosine 1154343 976901 561470 745014 338005 300296 299699 346269 446200 345353 398574 621518 acetyl-carnitine (acyl-C2) CAR 2:0 10741133 8820753 10800963 11225421 1776042 2064592 1646783 1901633 827221 769515 966873 879709 Acetylcholine Acetylcholine 540257 503567 805064 903379 265767 229136 175666 224340 106879 96659 104976 137168 Adenine Adenine 35978 38498 13614 46814 2599445 1237895 2313344 1491431 4923827 7269782 4918908 8213243 Adenosine Adenosine 179504 240410 97121 94972 3207024 3282300 2897682 3516796 4420556 5011320 4070454 7361396 Allantoate Allantoic acid 3986 7244 12765 18257 13934 8938 13496 7470 7729 2541 10249 AMP AMP 500204 323832 381710 449967 408555 242301 322334 348950 231466 177191 197621 212193 butanoyl-l-carnitine (acyl-C4) CAR 4:0 970528 889383 655848 995943 42670 36387 27638 34092 97813 57969 97795 80223 Cadaverine Cadaverine 58461 40945 15485 53362 5986 2195 6915 2014 Choline Choline 29814186 23574576 20667490 19311790 32413914 24633776 22201254 22837704 20538598 21361154 16491917 24445570 CMP CMP 117832 122329 104992 103694 67178 30022 48836 40961 9607 24242 15622 34181 Creatine Creatine 30444446 28342112 32876776 34654436 11466475 9274064 7658478 10010311 16259255 14251531 15225801 16553985 Creatinine Creatinine 135032 130569 116624 137325 61067 54019 31200 35580 44466 30752 57571 47419 Cys-Gly Cys-Gly 259124 242762 246977 322035 77250 60091 48831 62636 59281 78414 91058 95726 Cytidine Cytidine 12962 5826 4531 801355 817768 742715 960921 63980 93245 75397 61620 Cytosine Cytosine 22512 10588 7285 9143 36307 35106 37254 50098 44303 39610 32203 48347 dAMP dAMP 149980 169246 152720 212354 56918 37141 10700 57985 67786 50832 68370 75803 D-Glucono-1-5-lactone 6-phosphate 6-Phosphonoglucono-D-lactone 17620 15572 33091 55542 1247083 1073641 677757 996893 33476 62130 21118 48552 D-Rhamnose Rhamnose 16680840 25219018 27769254 17497266 15703388 26357600 18906758 21236528 15700227 19101534 18837576 24079434 Folate Folic acid 2606 4278 47069 50374 41640 51406 11796 9441 13946 10043 gamma-L-Glutamyl-L-cysteine gamma-Glutamylcysteine 74608 51273 47120 39402 18489 5472 16104 6735 22506 41136 34064 47416 Glutathione disulfide Oxidized glutathione 88578 62671 101804 61881 49051 44382 40257 65549 91660 128237 130900 93027 GMP GMP 62749 42999 40341 36084 80037 90779 162032 106224 36080 32585 27990 40581 g-Oxalo-crotonate 4-Oxalocrotonic acid 4690 2166 2028 1446580 1571199 1540488 1811832 178236 190960 128153 308675 Guanine Guanine 3486 2462 3371 177472 155628 282785 229775 309869 481151 349861 506801 Hexadecenoyl-carnitine (acyl-C16:1) CAR 16:1 254481 254905 221121 207753 66944 94661 49141 58906 44565 33030 34445 56621 Homocarnosine Homocarnosine 80013 71681 61077 62593 85490 94179 73755 90255 78966 71594 71530 69237 Indole-3-acetaldehyde Indoleacetaldehyde 40625 40664 21744 24317 14110 7082 6241 11790 9376 8437 17407 21402 Indole-3-acetate Indoleacetic acid 151368 161946 160373 155838 185336 192680 149006 243072 30407 26977 40175 55650 Indolepyruvate Indolepyruvate 172686 124115 105182 131440 44167 47360 35073 26778 39737 32013 38895 35567 L-alanine Alanine 1873299 1839249 960536 1449300 1017454 761078 582263 750160 605128 489356 522599 689910 L-arginine Arginine 790670 875694 790815 841990 1405993 1232484 1438302 1696229 1057014 1522084 813558 1535090 L-asparagine Asparagine 15533 14431 19767 28455 193050 215190 241579 305134 103194 80326 74205 127645 L-aspartate Aspartic acid 172475 192749 185383 193803 410353 369211 419312 480910 231425 336655 226576 380082 L-Carnitine Carnitine 5483687 5209009 8477085 10655361 3169660 2911833 2403490 2373763 894349 909492 1010134 1047069 L-Citrulline Citrulline 7990 9388 10526 17539 51024 77396 66810 60151 18540 11225 6305 10800 L-cysteine Cysteine 13152 37748 25093 25438 20824 8896 14525 12593 8777 20522 6401 17866 L-glutamate Glutamic acid 7923250 7960536 6027780 8106199 4435238 3718165 3283682 4156250 2641219 2856216 2281330 3149223 L-glutamine Glutamine 935982 944938 647313 914996 682121 683041 510702 554099 207697 180960 190611 274676 L-leucine/isoleucine Leucine/Isoleucine 28326898 27728438 16190471 22520454 10938471 7327908 6561877 8064346 4868628 6354737 4895567 7719636 L-lysine Lysine 582956 463776 360100 465812 806131 600286 642685 718441 472182 536090 373525 542847 L-methionine Methionine 936779 879792 262683 698037 117522 26994 26023 54914 47968 96970 60804 150504 L-Methionine S-oxide Methionine sulfoxide 1353473 1294312 841788 1218954 651018 438240 364515 484754 440285 411780 383958 561842 L-Palmitoylcarnitine (acyl-C16) CAR 16:0 368964 286320 258852 295363 31388 28642 25232 25336 48609 32285 34529 55789 L-phenylalanine Phenylalanine 8641149 7749052 4062540 6054651 2773605 2120235 1737321 2202108 2492144 2135230 2837171 2788470 L-proline Proline 6426087 5863670 7431394 8379210 5952690 4920444 4260070 5237115 5353635 4661896 5457078 5704532 L-threonine Threonine 1559574 1501894 815657 1305492 584356 449412 331694 451658 462217 485371 411855 556418 L-tryptophan Tryptophan 34179836 29341934 15643304 22682026 9337091 7388415 5831083 7805330 9611108 7783963 9922408 10433795 L-tyrosine Tyrosine 7439467 6601476 3832023 6603968 3172631 2331310 1922002 2386512 1962329 1916696 1941655 2592297 L-valine Valine 16616528 14271747 8159048 12927261 6511198 5184616 4489852 5552623 4698647 4190017 4530799 5648100 N-Acetylornithine N-Acetylornithine 82926 105883 53546 87262 75874 45122 56596 70397 87897 81474 73225 86150 NAD+ NAD 471791 544049 508421 614358 519236 340553 266550 386206 379532 393236 291626 339304 Nicotinamide Niacinamide 365491 308368 269760 313971 445085 461019 401449 401892 225784 303336 248515 354877 O-octadecenoyl-L-carnitine (acyl-C18:1) CAR 18:1 83157 59955 71968 71980 19707 19239 13046 17220 18525 13112 19981 19177 O-tetradecanoyl-L-carnitine (acyl-C14) CAR 14:0 1319845 1269626 901796 1087468 65452 68192 37119 59716 60006 59937 89692 91904 propionyl-carnitine (acyl-C3) CAR 3:0 1492554 1367265 3776090 3416667 553828 504219 421475 548174 155358 175380 186791 234551 Putrescine Putrescine 173887 151309 158047 138998 177630 164317 144173 136013 210107 193904 225710 215898 Pyridoxal Pyridoxal 69509 67149 82409 79194 106512 90364 93823 100155 43983 59773 38220 41981 Pyridoxamine 5^-phosphate Pyridoxamine 5'-phosphate 52349 64231 31502 27450 22138 7749 15705 18496 23525 15650 21112 18641 S-Adenosyl-L-methionine S-Adenosylmethionine 95320 98700 81863 149918 58293 31908 51495 76496 7897 28269 7902 30053 Spermidine Spermidine 1089757 770008 578086 659091 489336 705900 429592 479359 2017155 1022277 2853389 1352301 Spermine Spermine 1222497 1123532 1193104 2063535 1497297 2063300 753993 841021 1617900 2551021 2487966 1438571 Sphingosine Sphingosine 8404317 7650043 3291069 5672290 2533072 1797035 2203390 2034944 2778907 3057142 2276300 2942783 Taurine Taurine 102445 98146 176424 209882 71792 72123 45436 57085 40916 36758 42215 60605