Metabolite_name RefMet_name 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 1 10 11 2 3 4 5 6 7 8 9 Factors - Factor:Berk Factor:Berk Factor:Berk Factor:Berk Factor:Berk Factor:Berk Factor:Berk Factor:Beta Thal Factor:Beta Thal Factor:Beta Thal Factor:Beta Thal Factor:Beta Thal Factor:Beta Thal Factor:Beta Thal Factor:Beta Thal Factor:Beta Thal Factor:Beta Thal Factor:Beta Thal Factor:WT Factor:WT Factor:WT Factor:WT Factor:WT Factor:WT Factor:WT Factor:WT Factor:WT Factor:WT Factor:WT 1-3-Bisphosphoglycerate 3-Phospho-D-glyceroyl dihydrogen phosphate 132000 10900 1280 10600 11800 53500 126000 17200 4750 29000 11300 389000 16300 4840 5550 7130 14000 4890 20700 256000 51000 86800 3560 22000 1950 179000 35200 86600 76400 1-4-beta-D-Xylan 35500 80400 32400 40300 86400 112000 57200 17600 37800 57100 58900 59800 25600 32400 30800 130000 21500 23200 30000 12200 23300 18400 84300 15000 515000 65500 28200 24200 1D-myo-Inositol 1-4-bisphosphate 16300 29800 70400 87700 45700 288000 51100 28900 582000 23900 10900 46400 403000 148000 186000 44000 201000 43000 70500 274000 612000 125000 262000 73400 267000 411000 55600 12500 30500 2/3-Phospho-D-glycerate 2-Phosphoglyceric acid 36100 121000 105000 234000 250000 435000 240000 32100 77700 71900 69200 54300 188000 191000 47400 30400 22900 97100 73300 248000 387000 56000 66500 57400 87900 481000 54800 14000 19100 2-Hydroxyglutarate/Citramalate 2-Hydroxyglutaric acid 10800 89600 72400 388000 267000 257000 101000 68300 1560000 201000 159000 43300 749000 300000 116000 197000 103000 187000 357000 112000 231000 106000 356000 138000 517000 262000 88900 12000 82700 2-Oxoglutarate 2-Oxoglutaric acid 9140 3320 39300 39200 63600 149000 14000 6230 79700 18200 3170 7380 25900 10000 36100 69200 21000 81300 8350 7090 36400 146000 11200 53100 38900 11800 6210 3690 3-Phosphonooxypyruvate Phosphohydroxypyruvic acid 50100 73500 78800 71700 75600 134000 31200 111000 121000 32700 69100 33500 128000 63900 75300 83300 118000 103000 37600 28100 105000 15900 120000 37200 96600 43700 16100 35400 25100 5-10-Methenyltetrahydrofolate 5,10-Methenyl-THF 13800 7130 10500 8120 9270 29800 37800 2010 4780 27500 3490 7300 15500 2590 2320 3070 4530 4620 36800 22700 158000 3000 7020 4770 10900 6660 59700 5-Hydroxyisourate 5-Hydroxyisouric acid 5710 27300 10500 15200 11900 8620 15700 3130 5070 6530 9900 14900 8050 5730 5860 10400 14300 11400 13600 9170 26700 23700 11300 10800 13200 19900 5-Oxoproline Pyroglutamic acid 178000 314000 322000 700000 396000 611000 873000 226000 385000 305000 390000 255000 346000 692000 308000 317000 345000 544000 127000 60100 68600 172000 303000 214000 301000 93900 225000 116000 112000 6-Phospho-D-gluconate 6-Phosphogluconic acid 21300 5530 25800 7340 26100 11500 3590 37600 912 44100 17800 7010 4300 1980 13100 4430 16300 38600 12200 1480 12400 104000 ADP ADP 54800 392000 495000 1070000 1230000 1350000 392000 335000 2260000 504000 598000 91400 2590000 852000 630000 613000 569000 542000 772000 476000 892000 414000 1230000 413000 1330000 1020000 314000 53200 98400 ADP-D-ribose ADP-ribose 26200 82100 98200 72500 42600 49800 163000 22900 63700 62600 72900 85900 72300 85000 91300 11100 147000 5240 117000 a-Linolenic acid (Octadecatrienoic acid) Octadecatrienoic acid 113000 68800 60600 75000 59300 281000 488000 50500 56200 54900 22000 101000 65400 53100 24900 22400 35800 51800 28300 88100 110000 82500 25500 52000 34800 410000 75200 85700 71600 alpha-D-Ribose 1-phosphate Ribose 1-phosphate 37600 52000 140000 76700 231000 23400 62600 221000 15300 58400 8130 137000 187000 178000 104000 185000 109000 47600 36800 67100 201000 20800 168000 73000 7410 6000 Arachidonic acid (Eicosatetraenoic acid) Eicosatetraenoic acid 317000 130000 119000 170000 190000 779000 289000 124000 201000 112000 109000 187000 321000 146000 130000 107000 155000 137000 139000 337000 481000 229000 121000 132000 174000 497000 166000 256000 163000 Ascorbate Vitamin C 29600 38100 118000 33100 36600 2060000 26300 36100 5970000 49300 57800 15200 2680000 50400 51200 82400 34000 1020000 146000 400000 1120000 92100 2810000 90500 2370000 869000 433000 22800 37500 ATP ATP 22100 55100 164000 183000 423000 434000 91600 58500 543000 130000 104000 93100 1370000 147000 60300 53500 30100 48100 351000 1060000 2050000 420000 238000 199000 230000 753000 228000 24700 83100 Butanoic/Butyric acid Butyric acid 24200 17500 21300 18100 23000 13200 46600 40100 20100 19500 36600 17100 22100 48000 31100 41100 38600 14700 13200 13000 14400 48700 27900 29200 22700 16900 23800 24900 CDP CDP 6960 17400 13100 23100 35300 14000 1720 33700 16800 5670 5040 85400 23700 15100 6920 6580 22700 13600 81200 69800 29500 29000 16900 33300 83700 13600 Citrate Citric acid 1660000 2650000 4170000 8210000 9810000 10700000 3600000 605000 15900000 4300000 3090000 1720000 16900000 7500000 3410000 2900000 1780000 5270000 4840000 5590000 8710000 2860000 8640000 4370000 9550000 5000000 2920000 452000 1220000 CMP CMP 8450 10000 25500 13600 76500 3960 6590 24600 10800 32000 22600 74000 13100 55700 69400 4560 11200 10900 56900 4040 45500 35400 6980 CTP CTP 10600 15000 8690 8300 4350 5890 11500 6330 4560 9600 3090 12400 17800 21400 2080 1540 10700 7930 8920 61300 121000 19200 1360 4500 22600 37400 11100 9970 31900 D-Arabitol Arabitol 5820 4750 1930 4310 5590 12700 5600 3820 3600 2870 8170 3510 4900 3720 4040 13200 2940 5020 3500 980 2260 4030 6520 4050 2390 4600 4600 Decanoic acid (capric acid) Capric acid 173000 134000 131000 169000 88200 157000 122000 111000 127000 105000 72300 101000 228000 106000 94700 89200 215000 160000 134000 132000 119000 294000 104000 121000 143000 511000 107000 210000 197000 Dehydroascorbate L-Dehydroascorbic acid 34300 103000 184000 336000 460000 623000 150000 66000 867000 136000 137000 37300 786000 325000 200000 323000 243000 260000 141000 351000 627000 113000 503000 133000 417000 506000 113000 22700 42700 D-Fructose 1-6-bisphosphate Fructose 1,6-bisphosphate 16300 29800 70400 87700 45700 288000 51100 28900 582000 23900 10900 46400 403000 148000 186000 44000 201000 43000 70500 274000 612000 125000 262000 73400 267000 411000 55600 12500 30500 D-Glucose Glucose 110000 342000 188000 290000 451000 385000 223000 151000 440000 131000 216000 382000 336000 212000 157000 366000 333000 197000 93200 82600 101000 133000 361000 84600 252000 15200000 347000 120000 131000 D-Glucose 6-phosphate Glucose 6-phosphate 16000 171000 156000 429000 185000 254000 126000 68400 865000 150000 63100 47900 945000 359000 293000 92500 279000 290000 371000 375000 895000 191000 516000 347000 791000 2940000 129000 15500 24700 D-Glyceraldehyde 3-phosphate/Glycerone phosphate Glyceraldehyde 3-phosphate 7620 17000 55600 159000 48900 159000 5330 256000 714000 33200 51000 4210 267000 460000 507000 177000 432000 112000 68600 46500 112000 9270 472000 34400 399000 326000 6870 8720 6140 Dihomo-gamma-linolenic acid ((8Z-11Z-14Z)-Icosatrienoic acid) Dihomo-gamma-linolenic acid 108000 38500 34700 112000 60700 374000 449000 82300 67800 54000 29400 45600 112000 61500 31700 29400 36100 66700 35400 85900 113000 152000 34000 38600 36200 160000 90600 59200 91400 Diphosphate Pyrophosphate 13500000 4300000 2030000 5410000 7220000 8520000 10900000 312000 5250000 8360000 1560000 17700000 12000000 5160000 1610000 807000 416000 2860000 9620000 18200000 14800000 17200000 3110000 10000000 4650000 3270000 9880000 13100000 18300000 Docosahexaenoic acid Docosahexaenoic acid 224000 58400 56200 64100 100000 318000 148000 49500 103000 54900 55100 121000 101000 78300 65900 46600 52400 61700 50700 257000 241000 173000 54600 94700 72800 574000 122000 167000 118000 Docosapentaenoic acid ((7Z-10Z-13Z-16Z-19Z)-Docosa-7-10-13-16-19-pentaenoic acid) DPA 63400 20600 18600 25900 39300 162000 52200 21200 50800 23500 21700 40800 58500 35400 25700 16900 28700 33700 20500 83300 138000 58200 18500 22400 24500 155000 36200 77100 44400 Dodecanoic acid (lauric acid) Lauric acid 408000 297000 188000 402000 257000 411000 853000 155000 218000 191000 143000 240000 408000 202000 158000 109000 249000 109000 342000 303000 317000 1570000 235000 239000 169000 293000 266000 1200000 488000 D-Ribose Ribose 35100 37800 55300 43800 47500 46600 38500 46700 41800 52100 47300 38700 15800 33700 53000 55800 53800 30600 57400 37200 51900 34000 51000 51900 38900 414000 38400 35500 23300 Eicosapentaenoic acid Eicosapentaenoic acid 1430000 428000 286000 1140000 604000 3210000 4250000 232000 509000 724000 305000 97900 1240000 543000 236000 110000 451000 369000 352000 382000 215000 817000 162000 429000 156000 228000 713000 561000 1220000 Ethanolamine phosphate Phosphoethanolamine 42600 126000 224000 354000 412000 1060000 180000 441000 1040000 208000 393000 66100 589000 514000 544000 612000 873000 594000 180000 290000 403000 155000 889000 134000 513000 457000 254000 39300 52200 Fumarate Fumaric acid 20000 56200 54400 241000 83700 235000 103000 42500 318000 63900 55300 17800 262000 167000 60300 69300 54400 138000 49900 46600 63300 23900 148000 62700 190000 113000 67400 32300 58600 GDP GDP 1150 19600 24700 46200 107000 158000 47500 18400 102000 46100 37200 18000 221000 53000 30900 19500 27600 22100 75800 184000 264000 82900 49500 56800 54600 231000 68700 6520 5220 Glutathione disulfide Oxidized glutathione 20100 49700 30300 67300 66300 367000 53900 68100 200000 33800 99100 18800 121000 109000 65400 84600 72400 49300 46700 131000 87200 17300 161000 19600 79300 86500 16300 8120 5070 GMP GMP 57400 62500 202000 144000 412000 37600 83900 577000 57800 128000 222000 270000 301000 304000 590000 286000 71100 49300 52700 3910 514000 59300 325000 62600 18200 Heptanoic acid Heptylic acid 140000 130000 101000 144000 80200 109000 143000 126000 124000 101000 90500 105000 160000 104000 102000 87800 162000 198000 122000 126000 121000 214000 109000 104000 136000 127000 76500 144000 184000 Hexadecanoic acid (palmitic acid) Palmitic acid 30400000 15200000 11500000 28400000 19000000 68900000 67300000 19500000 32600000 24900000 9270000 37300000 195000000 20500000 12700000 11400000 14600000 19200000 25100000 18600000 30300000 43200000 21100000 21500000 21300000 39600000 42500000 27100000 46200000 Hexadecenoic acid (Palmitoleic acid) Palmitoleic acid 3160000 1780000 1220000 3600000 1570000 12100000 16300000 2410000 2100000 1780000 861000 541000 3650000 1720000 1060000 769000 1140000 1510000 1480000 1220000 1340000 5180000 653000 1620000 824000 2930000 2090000 1950000 3500000 IMP IMP 45500 395000 777000 89500 752000 12200 675000 1520000 60900 502000 296000 1530000 1220000 1440000 2560000 558000 27200 25600 7600 1920000 46100 1170000 Itaconate Itaconic acid 49855.9200 83072.6000 85830.8800 207479.5000 263868.8000 393673.8000 111270.3000 60354.4300 552596.6000 122810.9000 130229.3000 54271.7900 407634 215136.4000 135204.2000 137081.2000 108009.2000 168090 150194.4000 189239.4000 350539.8000 90427.1500 242563.4000 99976.5900 241992.7000 250711.6000 83861.3800 11644.8800 56411.5000 Lactate Lactic acid 3390000 1420000 1670000 2470000 3640000 6440000 4750000 1810000 4350000 2740000 2130000 2310000 1810000 2550000 1950000 1730000 2650000 2040000 2360000 2360000 1470000 1410000 2070000 2020000 1650000 6070000 2400000 1950000 1880000 L-aspartate Aspartic acid 218000 858000 1200000 1740000 1460000 4200000 1550000 1020000 1250000 634000 1110000 147000 2090000 1840000 878000 849000 906000 1710000 345000 330000 420000 262000 2420000 457000 1140000 326000 442000 119000 85300 L-Cysteate Cysteic acid 54900 75700 28200 49000 37600 25700 20800 52600 52800 39900 42700 51100 42000 53400 39900 45200 43500 63600 58300 32200 59900 53700 32900 44200 61400 50600 38800 34300 60500 Linoleic acid ((9Z_12Z)-Octadecadienoic acid) Linoleic acid 2060000 1030000 796000 1460000 1360000 4650000 5820000 741000 1020000 1090000 21800 1690000 1670000 935000 416000 409000 648000 985000 19300 1900000 2650000 1980000 665000 1100000 673000 10000000 1600000 1220000 1210000 L-Selenomethionine Selenomethionine 105000 98700 100000 125000 141000 115000 144000 38200 152000 143000 93700 197000 98100 151000 90600 69600 39500 115000 154000 113000 101000 96200 109000 204000 94400 112000 110000 104000 114000 Malate Malic acid 536000 540000 605000 3360000 1110000 2780000 1250000 276000 4130000 626000 670000 244000 2940000 1950000 748000 679000 503000 1600000 811000 394000 666000 343000 1630000 726000 2130000 1480000 480000 242000 352000 Mannitol Mannitol 834000 637000 307000 416000 657000 1220000 559000 58700 1220000 593000 202000 232000 1300000 604000 163000 177000 128000 320000 585000 438000 800000 1360000 646000 1230000 1490000 503000 1990000 786000 430000 Nonanoic acid (pelargonic acid) Pelargonic acid 259000 255000 188000 332000 146000 199000 356000 201000 234000 229000 166000 187000 668000 221000 211000 171000 534000 432000 266000 318000 257000 675000 240000 206000 245000 352000 129000 256000 322000 Octadecenoic acid (Oleic acid) Oleic acid 5270000 3250000 2420000 5350000 3220000 19200000 20300000 3570000 5680000 3400000 1460000 2980000 11600000 2840000 2100000 1550000 2130000 3570000 3880000 2850000 4990000 8960000 2870000 2700000 3700000 13600000 3830000 2960000 4220000 Octanoic acid (caprylic acid) Caprylic acid 4260000 1470000 684000 1640000 1750000 1790000 2850000 992000 1680000 1750000 1240000 2720000 2740000 1170000 893000 749000 1250000 1770000 1250000 1850000 814000 4830000 873000 1690000 1830000 7010000 2100000 3800000 3050000 Ornithine Ornithine 26000 15300 16600 47500 21500 47600 123000 20000 19600 16200 17900 21200 24400 36100 13600 8940 26100 24500 14200 7120 7240 30600 15300 11100 9670 13500 18500 23800 8850 Oxaloacetate Oxaloacetic acid 9542.1040 10620.1000 27741.6500 16394.9100 2507.4520 4151.0760 3988.9030 16101.6500 2603.6550 8872.8240 20096.0900 7898.9210 2542.6260 628.2532 16966.5600 22864.2200 10988.1700 16368.4200 2698.6170 1539.7700 811.7175 17553.5600 5840.7990 9596.9260 6848.2750 3149.5910 1278.7810 1264.1800 Pentanoate (valerate) Valeric acid 73700 113000 108000 84900 35700 33700 53700 123000 69000 57900 120000 28500 64700 86200 110000 99700 122000 114000 42400 37000 47800 68100 132000 58000 86800 30100 17100 49400 39400 Phosphate Phosphoric acid 71400000 33700000 26900000 48300000 58500000 54500000 68900000 9200000 46300000 59900000 22100000 82100000 86500000 45700000 22300000 14200000 12900000 32400000 60100000 89000000 79400000 96700000 30000000 65000000 46100000 32100000 66100000 69900000 96600000 Phosphocreatine Phosphocreatine 5490 48100 59500 26400 57100 63600 47100 9710 35900 17900 34700 2930 280000 56300 21100 16700 1390 69400 40700 75100 178000 75500 62500 52100 102000 257000 52400 13200 Phosphoenolpyruvate Phosphoenolpyruvic acid 12900 6770 4670 14800 30100 27400 18800 7260 825 26500 31400 6810 4930 4820 24000 144000 11400 2300 5460 60800 12700 2710 2620 Pyruvate Pyruvic acid 233562.8000 222484.4000 242405.9000 287525.7000 449028.2000 650546.8000 272440.2000 245422.7000 492873.6000 264238.3000 308170.7000 163938 300661.8000 312574.5000 236311.2000 387401.8000 214477.6000 204099.4000 250950.8000 159179.6000 224229.1000 133387.8000 297171.2000 267324.6000 190032.2000 382563.8000 240640 170009.6000 175069.2000 Succinate Succinic acid 87100 71800 62200 257000 241000 305000 167000 49600 210000 201000 121000 132000 178000 102000 58800 118000 63900 94000 138000 56400 85700 47900 102000 171000 86100 86600 178000 113000 155000 Taurine Taurine 501000 4080000 10100000 17600000 17800000 28900000 3660000 18000000 38600000 5140000 13400000 708000 21500000 14500000 15100000 25500000 28900000 11500000 6640000 5240000 12500000 2940000 21600000 4110000 20400000 5880000 3420000 484000 804000 Tetradecanoic acid (myristic acid) Myristic acid 1560000 1180000 804000 1650000 846000 4350000 6850000 1040000 1070000 1160000 518000 621000 2280000 927000 651000 475000 749000 1040000 1080000 664000 811000 2900000 580000 972000 510000 1090000 1110000 1650000 1890000 Tetradecenoic acid (myristoleic acid) Myristoleic acid 238000 141000 86900 307000 109000 755000 1170000 123000 114000 174000 68100 77600 229000 96200 78200 54400 117000 126000 162000 90000 147000 404000 67200 121000 75400 244000 156000 151000 272000 UDP-N-acetyl-D-glucosamine UDP-N-acetylglucosamine 4500 46900 105000 212000 326000 427000 56800 53800 432000 46900 90300 15500 389000 175000 142000 132000 149000 122000 89100 106000 212000 77500 381000 68100 225000 125000 48400 19800 UMP UMP 48700 37000 175000 139000 349000 59600 21700 307000 27300 50600 220000 190000 174000 73300 161000 152000 47000 55000 106000 17000 280000 29000 241000 120000 22600 UTP UTP 14500 12500 11300 49900 45800 23700 2840 45300 21100 5500 26500 168000 24200 1610 6120 2740 48700 256000 465000 86500 19200 26300 22500 107000 47800 10600 9940