metabolite_name	Serum_Tglif-F_1f	Serum_Tglif-F_1m	Serum_Tglif-F_2f	Serum_Tglif-F_2m	Serum_Tglif-S_1m	Serum_Tglif-S_2f	Serum_Tglif-S_2m	Serum_Tglif-S_3m	Serum_WT-F_1f	Serum_WT-F_1m	Serum_WT-F_2f	Serum_WT-F_2m	Serum_WT-S_1f	Serum_WT-S_2f	Serum_WT-S_3f	Serum_WT-S_3m
Glutathione disulfide	0	0	2245.332	2671.556	2369.926	2931.481	3798.929	0	16826.4	2985.287	2386.024	3319.486	3145.66	2933.573	4127.693	31505.53
Lysine	5912252	4676109	4977068	5247686	6951798	4466653	5308115	2321908	4419640	4559076	6358736	3717495	5103060	4607622	4966694	4852248
Arginine	3.49E+07	3.20E+07	3.12E+07	3.15E+07	3.25E+07	3.16E+07	3.22E+07	2.02E+07	2.81E+07	3.08E+07	3.25E+07	2.28E+07	2.31E+07	2.32E+07	2.04E+07	2.49E+07
Ornithine	1193756	1163343	678068.4	702266.2	1085146	783067.6	1086653	448066.2	1907298	1821509	1649122	1352522	697882.4	786579.5	520145.6	976190
Homoarginine	138743.2	192917.3	134116.5	107051.9	184865.6	146329.8	175191.2	63410.5	184740.3	209239.8	252909.9	131904.1	180278.6	160717.8	148147.8	157371
Glucose-6-phosphate	0	2966.797	0	2510.877	0	2710.275	2569.471	0	3449.942	0	0	2952.208	0	2713.535	2152.52	13220.95
Phosphocholine	131888.2	123343.7	136068.3	111320.3	110673	208454.1	156381.9	73999.36	75326.63	138361.6	68419.76	85563.21	102934.9	81314.81	183206.8	143047.9
GMP	0	0	0	25999.54	3840.787	34024.15	49074.17	4326.846	0	0	0	0	0	0	2628.586	15884.16
NG-dimethyl-L-arginine	1769344	1363973	1519938	1538680	1511426	1616758	1544575	919825.6	986471.7	1159349	1270442	1042252	1705267	1914750	1475167	1535410
S-adenosyl-L-methionine	7819.613	3678.71	0	7495.605	3370.63	2383.506	8548.58	2232.703	10118.32	2399.712	7738.542	0	0	6370.044	2981.713	9112.654
Creatine Phosphate	129271.6	161124.1	117012.4	202091.5	132139.2	231229.8	240829.1	99786.09	144100.6	208712.2	88323.94	139645.9	171834.8	193546.8	295348.5	458914.7
UMP	0	0	0	8137.1	8618.945	10263.15	34139.19	2038.104	0	0	0	0	0	0	0	3679.183
Glycerol-3-phosphate	44158.44	58731.77	26864.38	83088.97	45891.22	33080.73	60358.33	41605.68	59848.1	27854.46	37407.78	49530.71	39588.15	50024.46	42638.05	90707.27
Cystine	105644	85973.84	138191.3	157889	212112	90894.76	137616.7	33599.69	89103.59	152845.6	191796.3	109064.2	219085.1	159671.7	142354.6	163984.3
AMP	6154.701	2900.008	0	147619.8	34919.35	209771	365676.6	62225.11	0	0	3066.48	0	0	3466.324	0	42106.65
Carnosine	56736.51	41656.53	53648.3	46185.05	37425.75	60634.18	68407.03	23370.63	47681.9	49429.83	46434.09	34630.39	81834.75	73482.09	94772.02	154933.2
Glutathione	53903.69	39057.52	67890.3	34839.41	48434.64	149172	31132.98	20733.7	140308.2	68733.93	48388.01	57874.73	37322.72	46832.09	67068.79	46052.05
Aspartate	37307.03	21899.79	30538.09	33601.94	29744.94	22501.87	39497.1	23704.48	48168.42	33458.87	22809.98	18015.01	11308.61	24936.2	27485.82	55343.81
Homocarnosine	2288.505	0	0	0	0	20460.79	20035.74	0	0	0	2016.002	2555.669	0	2265.729	3287.679	0
Anserine	18325.48	20622.97	21585.58	43705.55	30576.12	22725.28	42969.66	21722.69	31938.96	52864.28	21411.12	58990.11	32004.53	26600.7	38432.63	96595.82
Glutamate	475159.9	509574.4	469242	401761.5	410195.7	743048.4	708449.8	390294	890156.1	1005720	366620.9	587232.6	432434.5	491943.6	694116.2	896150.1
N-acetyl-glutamate	19540.37	13969.24	3609.015	19979.1	7041.662	3056.49	4043.486	5170.18	32567.61	28042.07	35240.49	55915.2	2216.764	4027.243	3641.343	10704.77
Glycerophosphocholine	1466624	778870.8	1488610	957654.5	1177633	1153985	967733.2	613380.5	802079.3	1018120	1084279	1235701	1081647	1231829	1495116	1346113
Acetyllysine	57235.49	60179.3	45784.86	3454.174	49700.08	22920.93	31081.72	32614.98	44595.3	51886.63	54176.36	43683.36	43811.04	20228.91	47116.42	54330.03
Asparagine	266050.7	272222.2	292952.8	290809.9	354489.5	493201.7	254763.3	191018.6	649515.3	899428.5	465923.9	441542.3	363670.9	295940.1	331758	273111.5
Homocitrulline	21811.43	40402.55	33129.07	42693.99	20185.22	12291.12	26974.52	10274.8	20171.88	44245.34	40553.92	48115	38862.61	53574.53	48862.98	36708.32
Serine	340830.8	313117.6	310410.8	383156.8	423922.3	404480.5	353841.2	152104.2	656171.1	618647.1	554687.1	459881.2	421439.7	403769.9	392529.2	444396.9
Glutamine	2.34E+07	2.45E+07	2.41E+07	1.83E+07	1.85E+07	3.24E+07	2.27E+07	1.57E+07	1.98E+07	3.25E+07	2.10E+07	1.79E+07	3.13E+07	2.31E+07	2.86E+07	2.06E+07
Histidine	1368609	2021039	1693858	1626418	1903913	2641248	2677815	911022	2282794	2670117	2450529	1832875	1619496	2081706	1603869	1821633
1-Methylhistidine	622583.1	644486.8	574923.6	846845.7	811695.5	817798.7	935149.2	388814.7	265672.6	412457.1	532649.6	631182.9	845614.5	1150146	928512.7	888842.3
Methionine sulfoxide	85381.81	32523.2	51782.59	31608.66	9965.477	10322.24	12227.09	0	100431.8	194040.6	160024.9	150195.1	14589.93	6858.92	15810.3	3941.045
Acetyl-arginine	577694.8	551543.7	469759.5	268861.3	304684.1	447974.2	405603.5	302415	358130.3	617518.6	423125.5	487665	346787.4	365978.7	334053.5	213622.7
Glycine	102526.7	82510.82	3326.336	99735.49	125074.1	10596.71	118100.9	54636.58	174476.7	205406.4	136927.9	9061.914	14049.3	172024.9	8846.569	163614.8
Carnitine	7.26E+07	5.50E+07	8.55E+07	8.01E+07	8.47E+07	5.63E+07	4.71E+07	2.83E+07	8.02E+07	1.07E+08	1.04E+08	1.05E+08	1.02E+08	4.51E+07	6.68E+07	9.44E+07
Threonine	264613.7	204327.1	374970.7	867454.2	1050546	230244.2	749233.7	255478.1	1445454	430365.6	1676594	816113.3	436117.9	504493	219433.5	949563.3
4-Guanidinobutanoic acid	391425.1	360216	592842	184818.2	501640.2	125526.1	74324.87	144893	737758.3	720540.3	1198866	656385.3	101177.6	373304.7	191287.1	246866
Alanine	1567593	1740843	1374498	1715040	1729444	2029065	1728416	959943.2	2520815	2833810	2133899	1981621	1497411	1432569	1587616	1533592
Creatine	5.56E+07	6.38E+07	5.66E+07	6.49E+07	5.91E+07	8.20E+07	7.87E+07	4.68E+07	5.12E+07	5.20E+07	3.76E+07	4.77E+07	5.22E+07	6.46E+07	6.87E+07	6.85E+07
Hypotaurine	66315.34	52713.38	70962.76	38063.3	63585.06	231802.1	86180.97	36698.46	205727	258823.3	61005.03	137576.8	64325.6	31987.83	75163.54	98519.01
Imidozoleacetic acid	51607.77	26885.87	27413.38	29752.06	16909.72	12113.3	19060.78	10534.05	44088.3	57915.98	21692.44	9384.944	8645.978	5032.626	4057.774	17091.06
Thiamine	528727.1	408614.9	617990.9	239373.9	494984	217895.6	205104.9	75528.25	708641.2	871168.2	897124	1100285	724463.3	761148.4	732769.9	810282.4
Proline	7009806	4909948	5649870	5418898	5795128	6437052	4442678	3055249	1.06E+07	1.43E+07	1.06E+07	9718227	6772644	4648472	6519110	5687076
N-acetyl-L-ornithine	35141.59	8315.292	4893.236	79357.55	92276.7	3969.302	19420.24	4153.056	121849.9	64109.21	119432.8	88119.43	41966.99	80860.52	56738.06	177594.9
Dimethylglycine	941922.8	604969.1	700584.1	605038.3	676880.3	1073941	728051.2	478964	464506.8	473661.4	498326.2	543212.7	554700.9	501213.2	570798.3	511780.9
Methylnicotinamide	2116465	1796807	1948914	805203.5	928967.3	2716368	988420	981199.3	945418.4	424642	1665467	1634367	1659626	1690358	1449959	2635179
Methylguanidine	492632.7	371037.8	639508.8	226596.4	83116.54	68986.27	87560.19	120256.5	147668.6	363672.8	332580.8	395648.3	56795.5	61604.44	85346.12	122336.3
Tyrosine	1118209	1142158	1083276	1283695	1385986	1504524	1119638	654170.8	2818012	3396363	1789111	2227417	1491826	1089597	1372532	1401505
Betaine	4.38E+07	2.29E+07	3.71E+07	2.29E+07	2.82E+07	3.83E+07	2.07E+07	3.23E+07	6.44E+07	7.14E+07	5.59E+07	7.42E+07	9.73E+07	4.99E+07	8.41E+07	7.09E+07
1-Methylimidazole acetic acid	1632127	1960894	1527578	824512.6	668458.1	2028770	1534667	45195.12	342163.5	560433.2	441772	638621.6	709096.8	663539.2	916710.8	494639.2
Taurine	5011552	5672634	4264472	7469512	5531738	8920309	9114192	6890966	3388738	2077680	2508961	2167174	3195843	3285675	3517452	5542424
Urocanic acid	1692922	1004707	371812.8	625698.7	1046718	648629.1	702413.6	222866.9	576252.4	306065.5	549024.4	348338.2	227404.5	488029	973957.9	2036106
Methionine	2558908	2066651	2558440	2022746	2051190	1753792	1483818	875694.8	3199757	4190761	5128304	3772000	2215963	1380844	1847686	1668030
Pantothenate	234508.5	185123.9	235460.7	207409.1	128703.6	322963.4	211754.7	88221.21	140480	57094.16	152185	57783.53	114654.5	116707.6	108098.3	37414.14
Isoleucine	2732053	5044938	2905037	3642787	5300708	3035610	4258740	2852764	3213292	4479399	4103242	3538585	3482864	3793282	2974418	3207743
Cytidine	105759.1	111495.6	80563.32	108426.6	148822.7	142963.7	145908.4	101103.2	48109.37	48154.06	30582.66	40419.93	85037.62	104455.2	125952.7	134801.4
Leucine	4456092	9409214	4379036	5773758	8215332	4470615	6610150	4225292	5773876	7654984	6674850	6279254	5433170	5264942	3705375	4572793
Kynurenine	94035.44	79852.41	55211.92	90967.32	68664.35	49373.78	108649.6	49617.8	64242.62	52345.33	80668.12	44459.7	55945.88	58649.42	66185.7	41809.84
Phenylalanine	7921536	8631533	7316026	8853247	8384582	1.02E+07	7887660	4484910	9997011	1.16E+07	7049236	6955906	4403034	4055834	3725174	3902186
Tryptophan	4394458	3729052	5218516	4193508	4840196	4670568	3017158	1732176	6393654	6803740	6177264	5636266	3515817	4658386	3364550	3765565
N-Acetyltyrosine	2468.44	3928.628	3070.976	12727.04	16181.04	9894.067	14146.61	0	44794.42	9374.167	16519.75	2848.254	3022.681	13326.59	2321.207	14501.16
Hydroxyindoleacetic acid	10329.76	3102.93	0	22664.95	17629.53	0	18053.11	0	40223.53	0	44521.06	1822.773	7325.068	89033.12	0	24306.73
5-Methylcytosine	59653.06	61263.97	61104.81	22461.38	67171.5	83305.77	95577.2	41926.04	85766.88	69461.11	85055.27	53975.39	57559.56	80955.16	70072.9	98821.76
Creatinine	6996346	6284408	7076514	5621948	4615970	5725682	6246396	6385858	5603082	5611414	5994918	5340198	4695970	5799708	5959046	5235454
Hypoxanthine	10018.26	4578.542	10307.01	150214	41500.36	161807.7	77559.12	1365534	4854.121	2390.449	9051.807	1863.538	3667.176	5742.298	155321.3	129378.7
Acetyl-Methionine	3388.524	3636.117	0	25613.23	25825.21	15467.48	29878.46	0	32722.13	8040.34	36203.07	5251.56	0	10076.55	0	7429.586
Uridine	2757.816	0	0	32251.06	28448.39	0	25891.09	0	5693.873	0	6608.187	0	0	37122.81	2592.681	38413.29
Adenosine	232446.9	140614.5	260122.7	1943613	931528.2	895479.2	1778919	325868.9	73724.23	104799.1	227136.9	49989.34	241315	469831.8	1432417	1768199
3-Hydroxyanthranilic acid	53940.47	31729.35	49459.23	32971.37	32044.98	55517.88	45181.25	33960.78	4030.529	3550.726	3524.174	13316.13	21628.55	44556.06	31426.42	50037.02
Phenylacetylglycine	53144.24	11031.11	8719.7	125222.9	105352.1	13244.19	106978	3729.542	3628.891	0	26972	0	19267.48	73182.49	10624.06	44036.71
5- Methylthioadenosine	0	5308.732	6432.186	5385.806	4498.4	5584.021	9521.733	6316.743	7368.909	8438.614	0	6070.59	5332.266	6502.459	19674.63	10896.44
Acetoacetate	45691.3	44453.48	73445.6	41722.59	72208.21	34544.52	46188.64	20816.87	44903.76	102462.2	90854.97	91640.72	74212.29	30420.75	41666.8	69230.95
Guanidinoacetate	245845.4	177307.7	222137.6	458705.3	755568.2	380340.1	410767.2	123277.7	680272.3	338049.6	228055.7	171907.5	148589.5	237310	195101.1	496138.2
Citrulline	2497650	2034636	2047405	1707033	1879733	2394298	1981762	1028811	2150547	2298332	1934866	1515710	2101323	1377302	1951496	1534362
N-acetyl-glutamine	203667.7	143324	205104.3	104794.6	110511.2	276527.5	231666.5	108989.5	305638.6	350361.6	123568.9	167107.5	93256.51	173885.2	213535.7	220725.8
O-Acylcarnitine	98466.41	96442.79	103913.1	215703.2	212680.5	132993.9	228585.8	58355.88	235603.5	152402.2	210778.8	73308.81	110362.5	194937	100725	218384
O-Propanoylcarnitine	3936879	2519844	4302864	2946151	2998987	2700804	1578335	662823	5328710	7625710	4672258	6845582	4231776	1640366	3042308	4546644
O-Butanoylcarnitine	3268744	825479.7	3338094	1223534	1163243	1331156	1035340	368410.4	2286264	1430065	1972573	2646193	2169922	1434885	2333516	2313763
Mannose-6-phosphate	2362.977	3465.493	0	0	0	0	0	0	0	0	0	0	0	0	0	3283.108
Inosine	3704.797	0	2943.372	73522.02	0	101998.5	50355.41	113518.3	0	0	4677.219	0	3198.037	4165.025	112589.6	43870.83
L-Octanoylcarnitine	107660.2	81583	137651.7	75433.87	94682.29	186111.1	120385.4	34794.91	121622.4	64535.19	59835.31	97575.3	186803.5	181625.8	264473	191441.3
O-Decanoyl-L-carnitine	32072.37	49174.97	55255.56	12753.46	53575.79	67520.91	98460.37	53602.57	85180.73	22650.35	19247.18	39818.18	149194	203669.5	150815.5	146004.8
L-Palmitoylcarnitine	326243.9	293895.5	369593.6	773775.1	435176.8	1045884	793889.4	569068.1	467916.8	222657	265519.1	297722	682135	1138468	867561.2	671611.8

metabolite_name	medMz	medRt
Glutathione disulfide	613.1578	11.65688
Lysine	147.1126	13.95326
Arginine	175.1188	13.22308
Ornithine	133.097	13.02066
Homoarginine	189.1343	12.61251
Glucose-6-phosphate	261.0369	10.4757
Phosphocholine	184.073	11.07887
GMP	364.0647	10.14558
NG-dimethyl-L-arginine	203.15	12.01771
S-adenosyl-L-methionine	399.1434	10.87975
Creatine Phosphate	212.0428	9.536863
UMP	325.0427	9.497405
Glycerol-3-phosphate	173.0208	9.363317
Cystine	241.0312	9.460594
AMP	348.0699	9.285318
Carnosine	227.1136	9.292438
Glutathione	308.0905	8.714603
Aspartate	134.0445	8.744854
Homocarnosine	241.1292	9.570786
Anserine	241.129	9.08156
Glutamate	142.7724	8.578503
N-acetyl-glutamate	190.0708	8.093189
Glycerophosphocholine	258.1098	8.373573
Acetyllysine	189.123	8.455516
Asparagine	133.0606	7.873848
Homocitrulline	190.1182	7.916276
Serine	106.0497	7.883681
Glutamine	147.0762	7.686113
Histidine	156.0766	9.380851
1-Methylhistidine	170.0923	7.797101
Methionine sulfoxide	166.0536	7.45338
Acetyl-arginine	217.1293	7.504101
Glycine	76.03919	7.568465
Carnitine	162.1123	7.102666
Threonine	120.0654	7.128944
4-Guanidinobutanoic acid	146.0921	7.065082
Alanine	90.05482	6.839738
Creatine	132.0766	6.84566
Hypotaurine	110.0269	6.88231
Imidozoleacetic acid	127.0499	6.006427
Thiamine	265.1113	6.557364
Proline	116.0704	6.063031
N-acetyl-L-ornithine	175.1076	7.059944
Dimethylglycine	104.0705	5.801415
Methylnicotinamide	137.0708	5.981097
Methylguanidine	74.07116	5.266142
Tyrosine	182.0809	5.335153
Betaine	118.086	5.112202
1-Methylimidazole acetic acid	141.0656	4.812325
Taurine	126.0217	5.582836
Urocanic acid	139.05	4.537034
Methionine	150.0581	4.706096
Pantothenate	220.1179	4.246831
Isoleucine	132.1018	4.62724
Cytidine	244.0927	4.169606
Leucine	132.1018	4.177745
Kynurenine	209.092	3.75078
Phenylalanine	166.086	3.694656
Tryptophan	205.0968	3.567887
N-Acetyltyrosine	224.0914	2.921513
Hydroxyindoleacetic acid	192.065	2.871348
5-Methylcytosine	126.0661	3.062859
Creatinine	114.0661	2.924904
Hypoxanthine	137.0456	2.96522
Acetyl-Methionine	192.0689	2.851962
Uridine	245.0766	2.873704
Adenosine	268.1036	2.820856
3-Hydroxyanthranilic acid	154.0498	2.20588
Phenylacetylglycine	194.0813	2.318265
5- Methylthioadenosine	298.0961	2.10148
Acetoacetate	103.039	7.118601
Guanidinoacetate	118.0608	6.996783
Citrulline	176.1028	8.333546
N-acetyl-glutamine	189.0868	8.368731
O-Acylcarnitine	189.0996	6.964869
O-Propanoylcarnitine	218.1385	4.925212
O-Butanoylcarnitine	215.5715	3.882329
Mannose-6-phosphate	261.0369	10.19171
Inosine	269.0878	3.728175
L-Octanoylcarnitine	288.2166	2.117308
O-Decanoyl-L-carnitine	316.248	2.071009
L-Palmitoylcarnitine	400.3413	2.062573