#METABOLOMICS WORKBENCH hormel101_20180719_075927_mwtab.txt DATATRACK_ID:1463 STUDY_ID:ST001025 ANALYSIS_ID:AN001682 PROJECT_ID:PR000684
VERSION             	1
CREATED_ON             	July 19, 2018, 1:37 pm
#PROJECT
PR:PROJECT_TITLE                 	Mayo Pilot and Feasibility: H3K27M cells and glutamine metabolomics quatitation
PR:PROJECT_TITLE                 	studies
PR:PROJECT_SUMMARY               	In children, tumors affecting the brain and nervous system result in more
PR:PROJECT_SUMMARY               	cancer-related deaths than any other type of tumor. It is thus critical to
PR:PROJECT_SUMMARY               	identify new approaches for therapy. Among pediatric patients, one of the most
PR:PROJECT_SUMMARY               	devastating brain tumor types is Diffuse Intrinsic Pontine Gliomas (DIPG). Our
PR:PROJECT_SUMMARY               	understanding of this deadly disease has recently been advanced by important
PR:PROJECT_SUMMARY               	discoveries, including the discovery that the majority of DIPG tumors harbor the
PR:PROJECT_SUMMARY               	histone H3K27M mutation. This mutation results in global hypomethylation of
PR:PROJECT_SUMMARY               	H3K27 residues and is the pathological hallmark for this disease. Glutamine
PR:PROJECT_SUMMARY               	(Gln) addiction has been reported in many cancers including malignant adult
PR:PROJECT_SUMMARY               	gliomas. Glutamine likely promotes cancer cell proliferation and survival likely
PR:PROJECT_SUMMARY               	through generation of the TCA cycle intermediate alpha-ketoglutarate (α-KG).
PR:PROJECT_SUMMARY               	Importantly, α-KG is a critical co-factor for histone lysine demethylases
PR:PROJECT_SUMMARY               	including JMJD3, the enzyme responsible for removing the methyl groups from
PR:PROJECT_SUMMARY               	H3K27me3. Our preliminary data shows H3K27M tumor cells require Gln for
PR:PROJECT_SUMMARY               	survival, and if Gln is removed from the culture media, cells can be rescued by
PR:PROJECT_SUMMARY               	the addition of α-KG. Furthermore, Gln deprivation leads to an increase in
PR:PROJECT_SUMMARY               	H3K27 trimethylation similar to direct inhibition of JMJD3. It is for these
PR:PROJECT_SUMMARY               	reasons we hypothesize that H3K27M tumors are dependent on Gln derived α-KG
PR:PROJECT_SUMMARY               	both for feeding the TCA cycle and for further decreasing H3K27 trimethylation.
PR:PROJECT_SUMMARY               	Inhibition of Gln metabolism will likely uncover novel therapeutic targets for
PR:PROJECT_SUMMARY               	this deadly disease. In Aim 1 we will study Gln and glucose metabolism in H3K27M
PR:PROJECT_SUMMARY               	tumor cells and compare this to Wild Type (WT) tumors and Embryonic Stem Cells
PR:PROJECT_SUMMARY               	(ESCs). In Aim 2 we will validate the therapeutic validity of inhibiting Gln
PR:PROJECT_SUMMARY               	metabolism in H3K27M tumors.
PR:INSTITUTE                     	Mayo Clinic
PR:LAST_NAME                     	Daniels
PR:FIRST_NAME                    	David
PR:ADDRESS                       	200 First Street SW Rochester, MN 55905
PR:EMAIL                         	daniels.david@mayo.edu
PR:PHONE                         	507-284-2511
#STUDY
ST:STUDY_TITLE                   	TCA Isotopmer metabolomics of H3K27M Cells grown in regular media, glutamine
ST:STUDY_TITLE                   	enriched regular media, and glucose encriched regular media (Part-III)
ST:STUDY_SUMMARY                 	TCA Isotopmer metabolomics of H3K27M Cells grown in regular media, glutamine
ST:STUDY_SUMMARY                 	enriched regular media, and glucose encriched regular media. TCA isotopomers
ST:STUDY_SUMMARY                 	traced for 0, 12, or 24 hours were measured.
ST:INSTITUTE                     	Mayo Clinic
ST:LAST_NAME                     	Daniels
ST:FIRST_NAME                    	David
ST:ADDRESS                       	200 First Street SW Rochester, MN 55905
ST:EMAIL                         	daniels.david@mayo.edu
ST:PHONE                         	507-284-2511
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data
SUBJECT_SAMPLE_FACTORS           	-	ms6602-1	Sample type:Media | Grouping:IV Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-2	Sample type:Media | Grouping:IV Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-3	Sample type:Media | Grouping:IV Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-4	Sample type:Media | Grouping:IV Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-5	Sample type:Media | Grouping:IV Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-6	Sample type:Media | Grouping:IV Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-7	Sample type:Cells | Grouping:IV Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-8	Sample type:Cells | Grouping:IV Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-9	Sample type:Cells | Grouping:IV Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-10	Sample type:Media | Grouping:IV 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-11	Sample type:Media | Grouping:IV 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-12	Sample type:Media | Grouping:IV 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-13	Sample type:Media | Grouping:IV 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-14	Sample type:Media | Grouping:IV 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-15	Sample type:Media | Grouping:IV 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-16	Sample type:Media | Grouping:IV 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-17	Sample type:Media | Grouping:IV 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-18	Sample type:Media | Grouping:IV 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-19	Sample type:Cells | Grouping:IV 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-20	Sample type:Cells | Grouping:IV 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-21	Sample type:Cells | Grouping:IV 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-22	Sample type:Media | Grouping:IV 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-23	Sample type:Media | Grouping:IV 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-24	Sample type:Media | Grouping:IV 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-25	Sample type:Media | Grouping:IV 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-26	Sample type:Media | Grouping:IV 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-27	Sample type:Media | Grouping:IV 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-28	Sample type:Media | Grouping:IV 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-29	Sample type:Media | Grouping:IV 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-30	Sample type:Media | Grouping:IV 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-31	Sample type:Cells | Grouping:IV 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-32	Sample type:Cells | Grouping:IV 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-33	Sample type:Cells | Grouping:IV 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-34	Sample type:Media | Grouping:IV 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-35	Sample type:Media | Grouping:IV 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-36	Sample type:Media | Grouping:IV 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-37	Sample type:Media | Grouping:IV 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-38	Sample type:Media | Grouping:IV 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-39	Sample type:Media | Grouping:IV 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-40	Sample type:Media | Grouping:IV 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-41	Sample type:Media | Grouping:IV 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-42	Sample type:Media | Grouping:IV 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-43	Sample type:Cells | Grouping:IV 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-44	Sample type:Cells | Grouping:IV 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-45	Sample type:Cells | Grouping:IV 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-46	Sample type:Media | Grouping:IV 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-47	Sample type:Media | Grouping:IV 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-48	Sample type:Media | Grouping:IV 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-49	Sample type:Media | Grouping:IV 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-50	Sample type:Media | Grouping:IV 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-51	Sample type:Media | Grouping:IV 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-52	Sample type:Media | Grouping:IV 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-53	Sample type:Media | Grouping:IV 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-54	Sample type:Media | Grouping:IV 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-55	Sample type:Cells | Grouping:IV 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-56	Sample type:Cells | Grouping:IV 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-57	Sample type:Cells | Grouping:IV 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-58	Sample type:Media | Grouping:XVII Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-59	Sample type:Media | Grouping:XVII Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-60	Sample type:Media | Grouping:XVII Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-61	Sample type:Media | Grouping:XVII Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-62	Sample type:Media | Grouping:XVII Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-63	Sample type:Media | Grouping:XVII Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-64	Sample type:Cells | Grouping:XVII Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-65	Sample type:Cells | Grouping:XVII Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-66	Sample type:Cells | Grouping:XVII Basal	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-67	Sample type:Media | Grouping:XVII 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-68	Sample type:Media | Grouping:XVII 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-69	Sample type:Media | Grouping:XVII 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-70	Sample type:Media | Grouping:XVII 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-71	Sample type:Media | Grouping:XVII 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-72	Sample type:Media | Grouping:XVII 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-73	Sample type:Media | Grouping:XVII 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-74	Sample type:Media | Grouping:XVII 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-75	Sample type:Media | Grouping:XVII 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-76	Sample type:Cells | Grouping:XVII 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-77	Sample type:Cells | Grouping:XVII 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-78	Sample type:Cells | Grouping:XVII 12h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-79	Sample type:Media | Grouping:XVII 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-80	Sample type:Media | Grouping:XVII 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-81	Sample type:Media | Grouping:XVII 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-82	Sample type:Media | Grouping:XVII 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-83	Sample type:Media | Grouping:XVII 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-84	Sample type:Media | Grouping:XVII 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-85	Sample type:Media | Grouping:XVII 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-86	Sample type:Media | Grouping:XVII 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-87	Sample type:Media | Grouping:XVII 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-88	Sample type:Cells | Grouping:XVII 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-89	Sample type:Cells | Grouping:XVII 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-90	Sample type:Cells | Grouping:XVII 24h GLN	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-91	Sample type:Media | Grouping:XVII 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-92	Sample type:Media | Grouping:XVII 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-93	Sample type:Media | Grouping:XVII 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-94	Sample type:Media | Grouping:XVII 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-95	Sample type:Media | Grouping:XVII 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-96	Sample type:Media | Grouping:XVII 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-97	Sample type:Media | Grouping:XVII 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-98	Sample type:Media | Grouping:XVII 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-99	Sample type:Media | Grouping:XVII 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-100	Sample type:Cells | Grouping:XVII 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-101	Sample type:Cells | Grouping:XVII 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-102	Sample type:Cells | Grouping:XVII 12h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-103	Sample type:Media | Grouping:XVII 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-104	Sample type:Media | Grouping:XVII 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-105	Sample type:Media | Grouping:XVII 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-106	Sample type:Media | Grouping:XVII 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-107	Sample type:Media | Grouping:XVII 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-108	Sample type:Media | Grouping:XVII 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-109	Sample type:Media | Grouping:XVII 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-110	Sample type:Media | Grouping:XVII 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-111	Sample type:Media | Grouping:XVII 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-112	Sample type:Cells | Grouping:XVII 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-113	Sample type:Cells | Grouping:XVII 24h GLC	Species=Human
SUBJECT_SAMPLE_FACTORS           	-	ms6602-114	Sample type:Cells | Grouping:XVII 24h GLC	Species=Human
#COLLECTION
CO:COLLECTION_SUMMARY            	DIPG IV and DIPG XVII cell lines are collected in this experiment. Susupension
CO:COLLECTION_SUMMARY            	cells are harvested using centrifugation at 1200 rpm for 5 min. 1 mL of the
CO:COLLECTION_SUMMARY            	supernatant media werr collected in an eppendorf tube and snapped frozen. The
CO:COLLECTION_SUMMARY            	cell pellets were broken up into single cell suspension and counted. 1 million
CO:COLLECTION_SUMMARY            	cells were taken from the stock and washed 1 x with PBS using table top
CO:COLLECTION_SUMMARY            	centrifuge with 10 sec quick spin. The resulting cell pellet was snap frozen.
CO:COLLECTION_SUMMARY            	Both the frozen media and cell pellet are stored in -80 C prior transfer.
CO:SAMPLE_TYPE                   	Glioma cells
#TREATMENT
TR:TREATMENT_SUMMARY             	"TCA isotopomer in H3K27M cell lines traced for 0, 12, or 24 hours. Cells grow
TR:TREATMENT_SUMMARY             	in regular media without isotopes Cells grow in regular media enriched with 35%
TR:TREATMENT_SUMMARY             	U-13C-glutamine Cells grow in regular media enriched with 35% U-13C-glucose
TR:TREATMENT_SUMMARY             	Study Design Factors IV Basal - ""DIPG IV Regular Media No Tracers"" IV 12h GLN
TR:TREATMENT_SUMMARY             	- ""DIPG IV Gultamine enriched media 12 hour Tracers"" IV 24h GLN - ""DIPG IV
TR:TREATMENT_SUMMARY             	Gultamine enriched media 24 hour Tracers"" IV 12h GLC - ""DIPG IV Glucose
TR:TREATMENT_SUMMARY             	enriched media 12 hour Tracers"" IV 24h GLC - ""DIPG IV Glucose enriched media
TR:TREATMENT_SUMMARY             	24 hour Tracers"" XVII Basal - ""DIPG XVII Regular Media No Tracers"" XVII 12h
TR:TREATMENT_SUMMARY             	GLN - ""DIPG XVII Gultamine enriched media 12 hour Tracers"" XVII 24h GLN -
TR:TREATMENT_SUMMARY             	""DIPG XVII Gultamine enriched media 24 hour Tracers"" XVII 12h GLC - ""DIPG
TR:TREATMENT_SUMMARY             	XVII Glucose enriched media 12 hour Tracers"" XVII 24h GLC - ""DIPG XVII Glucose
TR:TREATMENT_SUMMARY             	enriched media 24 hour Tracers"""
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	TCA Isotopomers in glioma cell lines traced for 0, 12, 24 hours
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	GC
CH:INSTRUMENT_NAME               	Agilent 7890B
CH:COLUMN_NAME                   	Agilent HP5-MS (30m × 0.25mm, 0.25 um)
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:MS_COMMENTS                   	-
MS:INSTRUMENT_NAME               	Agilent 5977A
MS:INSTRUMENT_TYPE               	Single quadrupole
MS:MS_TYPE                       	EI
MS:ION_MODE                      	POSITIVE
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS         	Enrichment
MS_METABOLITE_DATA_START
Samples	ms6602-1	ms6602-2	ms6602-3	ms6602-4	ms6602-5	ms6602-6	ms6602-7	ms6602-8	ms6602-9	ms6602-10	ms6602-11	ms6602-12	ms6602-13	ms6602-14	ms6602-15	ms6602-16	ms6602-17	ms6602-18	ms6602-19	ms6602-20	ms6602-21	ms6602-22	ms6602-23	ms6602-24	ms6602-25	ms6602-26	ms6602-27	ms6602-28	ms6602-29	ms6602-30	ms6602-31	ms6602-32	ms6602-33	ms6602-34	ms6602-35	ms6602-36	ms6602-37	ms6602-38	ms6602-39	ms6602-40	ms6602-41	ms6602-42	ms6602-43	ms6602-44	ms6602-45	ms6602-46	ms6602-47	ms6602-48	ms6602-49	ms6602-50	ms6602-51	ms6602-52	ms6602-53	ms6602-54	ms6602-55	ms6602-56	ms6602-57	ms6602-58	ms6602-59	ms6602-60	ms6602-61	ms6602-62	ms6602-63	ms6602-64	ms6602-65	ms6602-66	ms6602-67	ms6602-68	ms6602-69	ms6602-70	ms6602-71	ms6602-72	ms6602-73	ms6602-74	ms6602-75	ms6602-76	ms6602-77	ms6602-78	ms6602-79	ms6602-80	ms6602-81	ms6602-82	ms6602-83	ms6602-84	ms6602-85	ms6602-86	ms6602-87	ms6602-88	ms6602-89	ms6602-90	ms6602-91	ms6602-92	ms6602-93	ms6602-94	ms6602-95	ms6602-96	ms6602-97	ms6602-98	ms6602-99	ms6602-100	ms6602-101	ms6602-102	ms6602-103	ms6602-104	ms6602-105	ms6602-106	ms6602-107	ms6602-108	ms6602-109	ms6602-110	ms6602-111	ms6602-112	ms6602-113	ms6602-114
Factors	Sample type:Media | Grouping:IV Basal	Sample type:Media | Grouping:IV Basal	Sample type:Media | Grouping:IV Basal	Sample type:Media | Grouping:IV Basal	Sample type:Media | Grouping:IV Basal	Sample type:Media | Grouping:IV Basal	Sample type:Cells | Grouping:IV Basal	Sample type:Cells | Grouping:IV Basal	Sample type:Cells | Grouping:IV Basal	Sample type:Media | Grouping:IV 12h GLN	Sample type:Media | Grouping:IV 12h GLN	Sample type:Media | Grouping:IV 12h GLN	Sample type:Media | Grouping:IV 12h GLN	Sample type:Media | Grouping:IV 12h GLN	Sample type:Media | Grouping:IV 12h GLN	Sample type:Media | Grouping:IV 12h GLN	Sample type:Media | Grouping:IV 12h GLN	Sample type:Media | Grouping:IV 12h GLN	Sample type:Cells | Grouping:IV 12h GLN	Sample type:Cells | Grouping:IV 12h GLN	Sample type:Cells | Grouping:IV 12h GLN	Sample type:Media | Grouping:IV 24h GLN	Sample type:Media | Grouping:IV 24h GLN	Sample type:Media | Grouping:IV 24h GLN	Sample type:Media | Grouping:IV 24h GLN	Sample type:Media | Grouping:IV 24h GLN	Sample type:Media | Grouping:IV 24h GLN	Sample type:Media | Grouping:IV 24h GLN	Sample type:Media | Grouping:IV 24h GLN	Sample type:Media | Grouping:IV 24h GLN	Sample type:Cells | Grouping:IV 24h GLN	Sample type:Cells | Grouping:IV 24h GLN	Sample type:Cells | Grouping:IV 24h GLN	Sample type:Media | Grouping:IV 12h GLC	Sample type:Media | Grouping:IV 12h GLC	Sample type:Media | Grouping:IV 12h GLC	Sample type:Media | Grouping:IV 12h GLC	Sample type:Media | Grouping:IV 12h GLC	Sample type:Media | Grouping:IV 12h GLC	Sample type:Media | Grouping:IV 12h GLC	Sample type:Media | Grouping:IV 12h GLC	Sample type:Media | Grouping:IV 12h GLC	Sample type:Cells | Grouping:IV 12h GLC	Sample type:Cells | Grouping:IV 12h GLC	Sample type:Cells | Grouping:IV 12h GLC	Sample type:Media | Grouping:IV 24h GLC	Sample type:Media | Grouping:IV 24h GLC	Sample type:Media | Grouping:IV 24h GLC	Sample type:Media | Grouping:IV 24h GLC	Sample type:Media | Grouping:IV 24h GLC	Sample type:Media | Grouping:IV 24h GLC	Sample type:Media | Grouping:IV 24h GLC	Sample type:Media | Grouping:IV 24h GLC	Sample type:Media | Grouping:IV 24h GLC	Sample type:Cells | Grouping:IV 24h GLC	Sample type:Cells | Grouping:IV 24h GLC	Sample type:Cells | Grouping:IV 24h GLC	Sample type:Media | Grouping:XVII Basal	Sample type:Media | Grouping:XVII Basal	Sample type:Media | Grouping:XVII Basal	Sample type:Media | Grouping:XVII Basal	Sample type:Media | Grouping:XVII Basal	Sample type:Media | Grouping:XVII Basal	Sample type:Cells | Grouping:XVII Basal	Sample type:Cells | Grouping:XVII Basal	Sample type:Cells | Grouping:XVII Basal	Sample type:Media | Grouping:XVII 12h GLN	Sample type:Media | Grouping:XVII 12h GLN	Sample type:Media | Grouping:XVII 12h GLN	Sample type:Media | Grouping:XVII 12h GLN	Sample type:Media | Grouping:XVII 12h GLN	Sample type:Media | Grouping:XVII 12h GLN	Sample type:Media | Grouping:XVII 12h GLN	Sample type:Media | Grouping:XVII 12h GLN	Sample type:Media | Grouping:XVII 12h GLN	Sample type:Cells | Grouping:XVII 12h GLN	Sample type:Cells | Grouping:XVII 12h GLN	Sample type:Cells | Grouping:XVII 12h GLN	Sample type:Media | Grouping:XVII 24h GLN	Sample type:Media | Grouping:XVII 24h GLN	Sample type:Media | Grouping:XVII 24h GLN	Sample type:Media | Grouping:XVII 24h GLN	Sample type:Media | Grouping:XVII 24h GLN	Sample type:Media | Grouping:XVII 24h GLN	Sample type:Media | Grouping:XVII 24h GLN	Sample type:Media | Grouping:XVII 24h GLN	Sample type:Media | Grouping:XVII 24h GLN	Sample type:Cells | Grouping:XVII 24h GLN	Sample type:Cells | Grouping:XVII 24h GLN	Sample type:Cells | Grouping:XVII 24h GLN	Sample type:Media | Grouping:XVII 12h GLC	Sample type:Media | Grouping:XVII 12h GLC	Sample type:Media | Grouping:XVII 12h GLC	Sample type:Media | Grouping:XVII 12h GLC	Sample type:Media | Grouping:XVII 12h GLC	Sample type:Media | Grouping:XVII 12h GLC	Sample type:Media | Grouping:XVII 12h GLC	Sample type:Media | Grouping:XVII 12h GLC	Sample type:Media | Grouping:XVII 12h GLC	Sample type:Cells | Grouping:XVII 12h GLC	Sample type:Cells | Grouping:XVII 12h GLC	Sample type:Cells | Grouping:XVII 12h GLC	Sample type:Media | Grouping:XVII 24h GLC	Sample type:Media | Grouping:XVII 24h GLC	Sample type:Media | Grouping:XVII 24h GLC	Sample type:Media | Grouping:XVII 24h GLC	Sample type:Media | Grouping:XVII 24h GLC	Sample type:Media | Grouping:XVII 24h GLC	Sample type:Media | Grouping:XVII 24h GLC	Sample type:Media | Grouping:XVII 24h GLC	Sample type:Media | Grouping:XVII 24h GLC	Sample type:Cells | Grouping:XVII 24h GLC	Sample type:Cells | Grouping:XVII 24h GLC	Sample type:Cells | Grouping:XVII 24h GLC
Citrate M0	99.40	99.84	99.43	96.68	98.83	99.75	98.50	98.70	97.97	97.47	99.19	99.85	99.01	99.52	99.59	97.64	97.91	96.93	80.06	78.90	72.77	99.91	99.89	99.99	99.52	99.71	99.95	94.88	94.26	91.86	78.61	78.74	70.78	99.51	99.12	99.64	99.16	99.12	98.08	97.62	98.21	97.74	91.51	88.19	87.35	97.98	97.56	98.24	99.41	98.00	99.04	96.25	95.26	94.16	85.21	85.42	83.97	99.52	99.70	99.55	99.42	98.99	99.29	99.74	99.90	99.98	99.65	99.55	99.70	99.54	99.88	99.69	93.06	87.88	87.56	72.03	61.40	64.49	99.71	99.64	99.24	99.03	99.45	99.60	88.42	88.71	80.00	73.21	73.80	64.85	99.91	99.91	99.80	99.76	99.84	99.63	97.92	97.72	97.54	88.94	88.02	88.36	99.70	99.76	99.64	98.67	99.37	98.68	94.90	95.16	95.11	86.79	86.73	87.07
Citrate M+1	0.32	0.00	0.00	2.27	0.74	0.11	0.64	0.25	0.32	1.74	0.00	0.00	0.81	0.29	0.28	0.36	0.07	0.77	2.22	2.59	4.89	0.00	0.00	0.00	0.25	0.00	0.00	0.00	0.84	1.08	3.15	2.74	6.37	0.00	0.00	0.00	0.00	0.32	1.35	0.95	0.48	0.83	1.41	2.38	3.09	1.42	2.10	1.39	0.00	1.47	0.24	0.66	1.07	1.58	3.70	2.50	2.99	0.00	0.00	0.00	0.40	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.13	0.00	0.00	0.00	0.22	1.11	0.94	3.56	5.36	5.13	0.00	0.00	0.48	0.00	0.00	0.00	1.98	0.83	2.36	3.59	3.37	5.02	0.00	0.00	0.08	0.02	0.00	0.00	0.16	0.34	0.19	2.33	2.75	2.30	0.00	0.00	0.00	0.00	0.00	0.00	0.66	0.83	0.37	2.92	2.93	2.68
Citrate M+2	0.00	0.00	0.53	0.00	0.00	0.00	0.02	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.06	4.41	4.66	6.71	0.00	0.00	0.00	0.00	0.00	0.00	0.96	0.66	1.61	5.10	5.05	8.11	0.00	0.34	0.00	0.15	0.00	0.00	1.13	0.71	0.95	6.67	8.90	8.98	0.42	0.15	0.16	0.00	0.00	0.00	2.73	3.54	3.41	10.17	10.94	11.90	0.37	0.10	0.34	0.00	0.17	0.32	0.20	0.00	0.00	0.12	0.30	0.00	0.28	0.00	0.00	1.33	2.12	2.42	6.46	9.11	8.30	0.00	0.13	0.00	0.74	0.20	0.20	1.49	2.18	3.86	6.22	6.00	8.25	0.00	0.00	0.00	0.00	0.00	0.00	1.58	1.73	1.72	8.03	8.48	8.60	0.10	0.00	0.00	0.12	0.00	0.04	3.93	3.53	4.00	9.28	9.43	9.22
Citrate M+3	0.00	0.00	0.00	0.00	0.00	0.00	0.08	0.17	0.15	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.24	2.06	1.97	1.94	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.81	2.09	2.02	2.01	0.22	0.00	0.24	0.00	0.00	0.00	0.00	0.00	0.27	0.28	0.33	0.32	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.55	0.71	0.67	0.03	0.11	0.07	0.00	0.44	0.00	0.05	0.05	0.00	0.00	0.00	0.00	0.00	0.02	0.26	0.77	1.76	1.40	3.38	4.81	3.49	0.00	0.01	0.00	0.00	0.31	0.00	1.48	1.49	2.65	3.23	2.91	4.04	0.00	0.00	0.00	0.09	0.03	0.18	0.16	0.08	0.34	0.49	0.52	0.54	0.00	0.00	0.00	0.83	0.41	0.80	0.30	0.24	0.31	0.72	0.61	0.71
Citrate M+4	0.12	0.00	0.00	1.02	0.38	0.11	0.00	0.00	0.00	0.72	0.75	0.07	0.00	0.09	0.00	1.91	1.69	1.88	10.81	11.42	13.15	0.00	0.00	0.00	0.18	0.18	0.00	3.62	3.83	4.23	10.36	10.99	12.27	0.00	0.05	0.01	0.40	0.21	0.41	0.25	0.44	0.00	0.08	0.18	0.24	0.00	0.00	0.16	0.55	0.41	0.42	0.24	0.02	0.50	0.31	0.31	0.42	0.00	0.08	0.00	0.10	0.35	0.26	0.00	0.04	0.02	0.13	0.07	0.08	0.00	0.07	0.00	3.91	6.22	6.99	12.62	16.91	17.51	0.11	0.11	0.25	0.06	0.00	0.16	5.60	5.94	9.56	11.68	12.27	15.64	0.02	0.04	0.06	0.06	0.05	0.11	0.11	0.06	0.03	0.16	0.17	0.14	0.14	0.09	0.19	0.16	0.09	0.21	0.07	0.10	0.10	0.24	0.22	0.26
Citrate M+5	0.00	0.00	0.03	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.06	0.07	0.00	0.00	0.00	0.22	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.03	0.36	0.20	0.03	0.36	0.12	0.29	0.00	0.00	0.00	0.01	0.33	0.13	0.03	0.13	0.18	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.28	0.10	0.07	0.36	0.06	0.11	0.04	0.06	0.00	0.04	0.04	0.00	0.10	0.00	0.00	0.00	0.06	0.09	0.08	0.15	0.04	0.04	0.63	0.82	0.57	1.91	2.14	0.94	0.18	0.07	0.00	0.14	0.00	0.00	0.96	0.81	1.51	2.07	1.58	2.01	0.03	0.00	0.02	0.04	0.01	0.00	0.00	0.06	0.16	0.05	0.05	0.05	0.06	0.14	0.10	0.12	0.09	0.24	0.13	0.13	0.09	0.05	0.06	0.05
Citrate M+6	0.12	0.14	0.00	0.00	0.04	0.00	0.04	0.02	0.00	0.04	0.03	0.00	0.11	0.08	0.14	0.00	0.00	0.00	0.06	0.10	0.19	0.09	0.11	0.00	0.06	0.09	0.00	0.00	0.00	0.00	0.09	0.14	0.15	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.05	0.02	0.02	0.18	0.17	0.02	0.00	0.10	0.00	0.02	0.00	0.00	0.00	0.00	0.00	0.03	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.07	0.12	0.04	0.27	0.10	0.00	0.00	0.04	0.00	0.00	0.00	0.00	0.04	0.03	0.00	0.07	0.19	0.05	0.05	0.05	0.03	0.05	0.08	0.06	0.01	0.02	0.00	0.01	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.03	0.02	0.01	0.01	0.00
Citrate M+7	0.03	0.02	0.02	0.03	0.01	0.03	0.72	0.87	1.57	0.03	0.03	0.01	0.00	0.01	0.00	0.09	0.10	0.12	0.38	0.37	0.35	0.00	0.01	0.01	0.00	0.02	0.02	0.18	0.20	0.38	0.25	0.20	0.02	0.27	0.49	0.10	0.28	0.01	0.03	0.03	0.04	0.03	0.00	0.00	0.00	0.01	0.02	0.03	0.04	0.03	0.02	0.00	0.04	0.00	0.00	0.00	0.01	0.00	0.00	0.00	0.04	0.06	0.04	0.01	0.01	0.00	0.03	0.00	0.00	0.03	0.00	0.00	0.08	0.02	0.00	0.00	0.00	0.04	0.00	0.04	0.00	0.03	0.04	0.04	0.07	0.00	0.03	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.02	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.07	0.09	0.03	0.02	0.00	0.00	0.00	0.00	0.00	0.01
Ketoglutarate M0	99.22	99.67	98.90	97.53	97.90	98.60	97.52	97.55	96.04	98.37	98.46	98.93	97.55	97.48	98.20	91.55	91.10	84.14	77.41	77.14	70.55	97.93	97.34	99.77	98.80	98.69	98.76	88.84	86.86	71.86	77.02	76.24	67.77	98.04	97.87	98.05	96.37	95.10	95.10	94.25	95.05	95.11	95.48	93.03	93.04	97.16	96.83	96.68	95.44	94.34	94.63	93.90	92.34	91.97	91.47	90.02	89.82	99.64	99.53	96.82	95.13	93.78	99.06	98.49	98.74	98.24	99.07	98.60	99.52	96.08	89.65	99.24	70.85	76.20	73.66	67.92	57.88	59.88	98.76	96.16	98.46	95.82	96.69	95.78	76.20	74.86	67.89	69.38	69.53	60.96	99.63	99.56	99.78	99.74	99.57	99.61	98.36	97.98	98.32	92.84	91.99	93.11	99.59	99.61	99.78	99.81	99.67	99.61	97.40	97.42	97.43	90.31	91.10	91.30
Ketoglutarate M+1	0.49	0.00	0.56	2.04	1.42	1.09	0.81	0.67	1.52	1.06	0.58	0.95	1.93	2.21	1.36	2.59	2.15	1.65	2.77	1.99	4.41	1.91	1.92	0.00	0.74	0.71	1.21	0.05	1.03	3.50	1.91	1.99	5.43	0.57	1.58	1.41	2.89	3.95	2.83	3.68	2.89	3.09	0.63	1.80	2.01	2.25	2.65	1.94	3.86	5.60	3.05	3.32	3.47	4.57	1.98	2.34	2.56	0.01	0.00	1.23	1.53	2.01	0.41	0.70	0.53	0.70	0.35	0.33	0.12	1.38	3.08	0.48	3.28	1.39	1.51	2.96	5.16	4.70	0.46	1.13	0.43	1.33	1.00	1.48	1.37	1.45	1.85	3.75	3.15	4.93	0.23	0.26	0.04	0.00	0.15	0.02	0.25	0.50	0.34	1.67	2.13	1.72	0.05	0.21	0.00	0.00	0.00	0.08	0.62	0.58	0.50	2.21	2.23	1.98
Ketoglutarate M+2	0.00	0.00	0.38	0.00	0.00	0.05	0.03	0.00	0.00	0.00	0.35	0.00	0.50	0.00	0.19	0.61	0.20	1.26	1.05	1.10	1.67	0.00	0.65	0.13	0.16	0.42	0.00	0.92	0.72	2.01	1.24	1.26	2.64	0.63	0.30	0.00	0.00	0.56	0.36	1.37	1.27	1.22	3.11	3.88	3.77	0.00	0.00	0.28	0.62	0.00	1.41	2.18	3.07	2.83	5.23	5.55	5.55	0.00	0.02	0.00	0.01	0.10	0.02	0.00	0.00	0.03	0.03	0.00	0.03	0.04	0.14	0.00	1.09	0.98	1.30	2.09	3.15	2.74	0.07	0.16	0.04	0.14	0.00	0.06	1.08	1.08	1.50	1.97	1.82	2.88	0.02	0.00	0.00	0.00	0.01	0.00	1.06	1.11	0.93	3.89	4.36	3.89	0.02	0.06	0.00	0.00	0.12	0.00	1.65	1.59	1.65	4.73	4.47	4.61
Ketoglutarate M+3	0.12	0.31	0.11	0.36	0.63	0.19	0.12	0.21	0.27	0.06	0.09	0.11	0.00	0.29	0.23	0.58	1.09	3.29	3.94	3.76	6.61	0.15	0.00	0.09	0.23	0.11	0.02	1.78	2.16	5.86	4.30	4.45	7.67	0.52	0.00	0.40	0.40	0.06	0.00	0.03	0.00	0.13	0.43	0.75	0.61	0.54	0.00	0.30	0.00	0.00	0.31	0.00	0.18	0.05	0.85	1.08	1.14	0.00	0.03	1.61	2.86	3.79	0.23	0.07	0.06	0.09	0.02	0.00	0.00	2.18	6.44	0.00	9.44	3.73	4.68	7.38	10.13	9.55	0.23	2.19	0.68	2.40	1.86	1.74	4.11	4.52	5.79	7.08	6.87	8.87	0.04	0.08	0.04	0.18	0.12	0.11	0.17	0.16	0.21	0.11	0.07	0.24	0.09	0.05	0.06	0.10	0.10	0.15	0.22	0.27	0.26	0.25	0.16	0.10
Ketoglutarate M+4	0.17	0.00	0.04	0.00	0.00	0.00	0.00	0.01	0.15	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.07	0.23	0.45	0.27	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.33	0.40	0.35	0.36	0.23	0.25	0.13	0.34	0.33	0.85	0.65	0.45	0.44	0.10	0.13	0.09	0.00	0.00	0.00	0.00	0.00	0.58	0.59	0.62	0.57	0.17	0.49	0.24	0.04	0.02	0.02	0.09	0.00	0.00	0.05	0.05	0.11	0.02	0.06	0.02	0.00	0.00	0.01	0.69	0.72	0.73	0.65	0.91	0.92	0.00	0.00	0.04	0.00	0.00	0.15	0.61	0.62	0.92	0.58	0.58	0.85	0.03	0.02	0.01	0.03	0.07	0.16	0.13	0.16	0.12	0.20	0.18	0.21	0.16	0.01	0.03	0.03	0.04	0.09	0.10	0.12	0.13	0.40	0.34	0.24
Ketoglutarate M+5	0.00	0.00	0.00	0.03	0.02	0.04	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	4.42	5.07	9.54	12.93	14.92	15.53	0.00	0.06	0.00	0.04	0.05	0.00	8.00	8.76	16.30	14.61	15.16	15.78	0.00	0.00	0.00	0.00	0.00	0.49	0.00	0.34	0.00	0.00	0.08	0.06	0.02	0.05	0.04	0.05	0.05	0.00	0.00	0.00	0.00	0.00	0.18	0.00	0.06	0.10	0.15	0.06	0.11	0.08	0.06	0.08	0.13	0.28	0.67	0.14	0.06	0.32	0.08	14.54	16.80	17.97	18.80	22.61	22.09	0.20	0.03	0.11	0.00	0.03	0.48	16.48	17.29	21.91	17.06	17.88	21.36	0.01	0.00	0.03	0.02	0.03	0.04	0.01	0.02	0.02	0.07	0.09	0.04	0.03	0.00	0.01	0.03	0.03	0.01	0.00	0.00	0.00	0.13	0.08	0.08
Ketoglutarate M+6	0.00	0.02	0.01	0.03	0.03	0.03	0.01	0.01	0.00	0.01	0.01	0.01	0.01	0.01	0.02	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.03	0.01	0.03	0.03	0.01	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.37	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.01	0.02	0.02	0.01	0.00	0.00	0.33	0.00	0.00	0.00	0.00	0.11	0.08	0.05	0.15	0.09	0.04	0.26	0.16	0.21	0.04	0.17	0.09	0.13	0.26	0.10	0.00	0.00	0.00	0.00	0.00	0.00	0.14	0.19	0.11	0.12	0.18	0.14	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.02	0.02	0.02	0.01	0.03	0.02	0.04	0.03	0.98	1.02	0.77	0.03	0.03	0.03	0.00	0.00	0.02	0.00	0.01	0.02	1.51	1.33	1.25
Succinate M0	78.40	83.75	93.14	84.61	79.10	88.91	97.43	97.55	97.76	83.45	85.17	93.85	86.54	81.74	93.02	83.35	82.40	88.21	78.81	77.45	68.38	85.80	84.66	90.40	84.85	85.20	89.81	81.16	82.08	80.26	76.23	76.01	65.74	96.63	98.19	98.92	99.08	98.52	96.33	98.20	98.38	97.68	97.87	94.84	94.17	95.52	95.68	97.76	98.55	98.15	98.01	96.81	97.03	97.37	94.46	93.23	94.12	94.39	95.95	97.44	94.25	94.69	94.57	97.75	97.06	96.76	95.28	95.59	96.43	93.82	93.68	95.75	88.65	85.28	85.39	68.96	59.01	59.92	93.88	94.76	93.51	93.17	94.45	92.83	86.29	85.02	79.00	70.13	69.83	62.43	97.91	98.68	98.51	98.58	98.19	98.34	97.91	97.78	96.80	92.56	92.49	93.59	98.17	98.79	98.87	98.44	98.15	98.13	97.72	97.65	97.68	90.63	91.13	91.32
Succinate M+1	10.51	10.57	5.34	11.17	18.62	10.53	2.37	2.20	2.10	14.36	12.54	5.90	12.63	16.97	6.74	13.79	13.62	4.76	3.91	3.46	6.06	12.02	13.30	8.93	14.55	13.78	10.06	12.54	9.73	6.29	4.79	4.58	9.79	2.56	0.36	0.33	0.00	0.08	1.62	0.00	0.15	0.49	0.79	2.58	2.82	2.14	2.47	0.61	0.00	0.00	0.00	0.98	0.00	0.00	1.86	2.67	1.68	3.62	2.15	1.36	4.17	3.72	4.09	1.39	2.24	2.90	3.39	3.32	2.66	4.73	4.78	3.10	3.59	3.63	2.96	4.84	6.94	6.90	3.64	3.77	4.67	5.07	4.18	5.63	3.37	3.69	4.01	5.27	5.54	6.87	1.53	0.96	1.23	1.13	1.45	1.09	1.18	1.35	2.00	3.27	3.25	2.44	1.20	0.82	0.70	1.12	1.34	1.24	0.84	1.03	0.82	4.76	4.87	4.54
Succinate M+2	3.86	2.50	0.59	2.02	0.85	0.01	0.10	0.17	0.08	1.49	1.70	0.06	0.00	0.88	0.00	0.53	1.03	2.31	3.68	4.21	7.37	0.68	1.62	0.59	0.26	0.74	0.00	1.61	2.38	3.68	4.67	4.59	8.03	0.38	1.13	0.48	0.37	0.82	1.29	0.54	0.49	0.91	1.09	2.45	2.91	1.15	0.82	0.64	0.10	0.06	0.12	0.53	1.14	0.95	3.49	3.92	3.88	0.52	0.58	0.44	0.40	0.33	0.32	0.34	0.29	0.08	0.37	0.16	0.14	0.32	0.54	0.46	1.71	2.53	2.75	7.17	9.74	9.87	0.71	0.49	0.78	0.50	0.50	0.60	2.39	2.48	3.83	7.14	6.86	7.88	0.12	0.02	0.02	0.11	0.00	0.20	0.58	0.51	0.70	4.15	4.21	3.93	0.24	0.05	0.16	0.13	0.17	0.29	1.25	1.11	1.25	4.43	3.80	4.01
Succinate M+3	0.64	0.34	0.19	0.52	0.08	0.19	0.00	0.00	0.00	0.00	0.00	0.01	0.46	0.03	0.16	0.00	0.00	0.21	0.66	0.79	0.91	0.00	0.00	0.00	0.00	0.18	0.00	0.00	0.16	0.47	0.86	0.86	0.69	0.00	0.00	0.00	0.10	0.00	0.00	0.26	0.17	0.08	0.00	0.00	0.02	0.00	0.03	0.19	0.38	0.58	0.35	0.49	0.49	0.36	0.03	0.02	0.01	0.14	0.11	0.08	0.11	0.25	0.12	0.05	0.03	0.00	0.15	0.16	0.15	0.14	0.10	0.09	0.32	0.45	0.43	0.88	0.97	0.89	0.20	0.09	0.06	0.16	0.10	0.15	0.45	0.48	0.91	0.76	0.82	1.14	0.17	0.06	0.05	0.03	0.10	0.08	0.08	0.08	0.15	0.00	0.03	0.01	0.04	0.09	0.05	0.10	0.10	0.08	0.03	0.07	0.07	0.15	0.12	0.11
Succinate M+4	6.58	2.84	0.75	1.68	1.35	0.36	0.10	0.08	0.05	0.64	0.50	0.17	0.37	0.38	0.08	2.33	2.95	4.51	12.93	14.09	17.29	1.50	0.37	0.05	0.33	0.08	0.12	4.69	5.65	9.29	13.45	13.96	15.74	0.43	0.32	0.28	0.45	0.58	0.75	1.00	0.81	0.84	0.26	0.13	0.07	1.19	0.99	0.80	0.97	1.22	1.52	1.18	1.33	1.33	0.16	0.17	0.31	1.34	1.22	0.69	1.07	1.01	0.90	0.47	0.39	0.25	0.82	0.77	0.62	0.99	0.89	0.60	5.72	8.12	8.48	18.16	23.34	22.42	1.57	0.89	0.98	1.10	0.76	0.79	7.50	8.33	12.26	16.70	16.95	21.68	0.27	0.28	0.18	0.15	0.26	0.28	0.23	0.28	0.36	0.00	0.00	0.00	0.34	0.25	0.20	0.21	0.23	0.25	0.16	0.14	0.17	0.01	0.03	0.02
Succinate M+5	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.06	0.10	0.02	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.05	0.03	0.00	0.02	0.01	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.00	0.01	0.00	0.00	0.02	0.02	0.03	0.00	0.01	0.00	0.00	0.01	0.00	0.01	0.00	0.00	0.03	0.05	0.00
Fumarate M0	81.27	86.44	90.95	90.30	88.66	95.25	99.68	99.88	99.75	94.83	95.78	97.60	95.47	95.64	97.88	95.29	95.01	96.02	82.26	81.36	74.21	96.62	97.94	98.40	97.07	94.99	97.04	92.50	91.63	90.37	80.33	79.81	72.11	98.47	98.20	99.04	97.78	98.21	94.21	99.11	99.59	99.83	97.64	95.84	94.92	99.72	99.49	98.69	99.78	99.42	99.22	99.22	99.30	99.29	95.76	95.87	95.50	86.88	89.09	91.45	88.91	89.93	89.95	97.08	97.97	98.08	90.98	92.37	93.37	90.57	91.42	93.53	91.76	90.02	91.56	80.12	72.64	72.73	93.53	94.40	94.50	93.75	94.63	94.05	92.38	91.99	88.88	78.43	78.49	71.14	99.42	98.18	98.28	98.32	97.05	97.69	98.24	97.54	97.96	95.58	95.50	95.50	98.90	98.77	98.13	98.73	98.81	98.75	98.37	98.15	97.89	95.78	95.81	95.58
Fumarate M+1	2.09	1.35	0.92	0.62	2.14	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.41	1.52	4.06	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.95	2.00	5.32	0.00	1.23	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.21	2.05	2.67	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.99	1.73	1.83	0.68	0.00	0.00	0.07	0.00	0.00	1.13	0.88	1.01	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	3.17	4.25	4.38	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	3.03	2.84	4.20	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.23	1.32	1.42	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.20	1.21	1.31
Fumarate M+2	4.90	2.64	1.49	1.50	2.22	0.03	0.17	0.00	0.00	0.00	0.26	0.00	0.42	1.21	0.00	0.00	0.20	0.00	3.30	3.64	6.41	0.64	0.33	0.11	0.00	2.44	0.00	2.07	2.35	2.63	4.13	4.28	7.17	1.13	0.20	0.59	2.14	0.64	3.69	0.39	0.00	0.00	1.08	1.83	2.19	0.23	0.00	1.26	0.00	0.00	0.00	0.00	0.00	0.00	1.71	2.09	2.19	3.31	3.08	2.65	3.26	2.65	2.76	0.64	0.55	0.52	2.36	1.79	1.90	2.19	1.64	1.40	1.63	2.34	2.08	4.53	6.42	6.32	1.51	1.31	1.36	1.18	1.00	1.36	1.29	1.51	2.81	5.08	4.83	6.62	0.41	1.82	1.71	1.35	2.68	1.80	1.31	1.96	1.54	2.32	2.50	2.28	0.98	1.16	1.54	1.01	0.92	0.89	1.56	1.61	1.73	2.36	2.33	2.49
Fumarate M+3	1.46	1.41	1.14	1.18	1.32	0.93	0.01	0.06	0.20	1.21	0.49	0.46	0.83	0.77	0.32	1.06	0.57	0.50	1.93	1.92	1.47	0.39	0.00	0.00	0.20	0.00	0.39	0.55	0.81	0.60	2.04	2.02	1.53	0.28	0.28	0.27	0.08	0.62	1.09	0.47	0.24	0.15	0.04	0.28	0.22	0.00	0.51	0.00	0.00	0.00	0.00	0.00	0.02	0.00	0.42	0.28	0.48	1.43	1.24	1.01	1.15	1.18	1.31	0.07	0.01	0.00	1.02	1.20	0.83	0.96	1.03	0.76	1.02	1.21	0.83	1.74	2.54	2.14	0.85	0.79	0.97	0.91	0.92	0.77	1.20	1.18	1.40	1.83	1.93	2.60	0.17	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.87	0.66	0.80	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.62	0.63	0.61
Fumarate M+4	10.27	8.16	5.49	6.40	5.66	3.79	0.14	0.06	0.05	3.96	3.46	1.94	3.28	2.38	1.80	3.65	4.22	3.48	11.10	11.56	13.86	2.35	1.73	1.49	2.73	2.57	2.57	4.88	5.21	6.40	11.55	11.89	13.87	0.12	0.09	0.11	0.00	0.53	1.01	0.02	0.16	0.01	0.04	0.00	0.00	0.01	0.00	0.00	0.22	0.58	0.78	0.78	0.68	0.71	0.12	0.03	0.00	7.70	6.59	4.89	6.61	6.24	5.98	1.08	0.58	0.38	5.63	4.64	3.89	6.27	5.90	4.31	5.59	6.44	5.53	10.44	14.15	14.43	4.11	3.50	3.18	4.16	3.45	3.83	5.14	5.33	6.91	11.63	11.92	15.44	0.00	0.00	0.00	0.33	0.27	0.51	0.45	0.50	0.50	0.00	0.02	0.00	0.12	0.07	0.34	0.27	0.27	0.36	0.07	0.25	0.38	0.05	0.01	0.00
Fumarate M+5	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.03	0.00	0.05	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Malate M0	99.66	99.56	99.89	99.25	98.52	99.65	99.34	99.44	99.59	99.54	99.66	99.77	99.43	99.54	99.89	95.11	95.39	95.85	79.92	78.81	70.31	99.18	99.37	99.72	99.49	99.49	99.79	91.73	91.15	87.66	78.67	78.11	68.46	99.83	99.66	99.67	99.76	99.86	99.86	99.91	99.79	99.80	96.46	94.47	94.17	99.89	99.57	99.86	99.68	99.66	99.57	99.40	99.44	98.94	92.96	93.10	93.26	98.41	98.78	99.38	98.68	98.73	98.62	99.32	98.73	98.78	99.15	99.72	99.76	99.30	99.58	99.12	94.84	90.16	92.93	68.16	58.75	60.05	99.14	99.04	99.17	99.39	99.24	99.30	92.20	91.42	84.32	70.97	70.99	62.69	99.68	99.69	99.49	99.65	99.68	99.69	99.57	99.60	99.61	94.58	94.29	94.34	99.71	99.81	99.76	99.74	99.75	99.75	99.34	99.49	99.43	93.37	93.73	93.45
Malate M+1	0.00	0.00	0.00	0.00	0.00	0.00	0.51	0.41	0.30	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.20	1.83	2.15	5.17	0.00	0.00	0.00	0.00	0.00	0.00	0.32	0.69	1.41	2.44	2.52	6.36	0.05	0.28	0.20	0.00	0.00	0.00	0.00	0.00	0.00	0.71	2.09	2.27	0.05	0.12	0.00	0.08	0.04	0.19	0.11	0.00	0.19	2.19	1.80	1.63	0.70	0.70	0.43	0.72	0.47	0.84	0.37	0.76	0.83	0.37	0.01	0.00	0.22	0.16	0.61	0.39	1.44	0.61	4.71	6.37	6.54	0.28	0.25	0.30	0.00	0.00	0.35	0.38	0.53	1.77	4.31	4.16	5.97	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.58	1.78	1.90	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	2.12	1.90	2.02
Malate M+2	0.00	0.00	0.00	0.00	0.00	0.00	0.10	0.08	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.39	0.65	0.65	3.87	4.05	7.27	0.00	0.00	0.00	0.22	0.00	0.00	1.32	1.10	2.66	4.46	4.59	8.38	0.00	0.00	0.00	0.19	0.01	0.00	0.00	0.11	0.03	2.30	2.90	2.99	0.00	0.00	0.00	0.00	0.00	0.00	0.33	0.28	0.57	4.18	4.39	4.28	0.00	0.00	0.00	0.00	0.00	0.00	0.13	0.10	0.28	0.00	0.00	0.00	0.00	0.00	0.00	0.69	1.48	1.15	7.29	9.91	9.50	0.00	0.00	0.00	0.00	0.00	0.00	1.47	1.50	2.71	6.83	6.69	8.94	0.00	0.00	0.00	0.00	0.00	0.00	0.12	0.16	0.14	2.85	3.00	2.81	0.00	0.00	0.00	0.00	0.00	0.00	0.44	0.34	0.41	3.37	3.10	3.27
Malate M+3	0.27	0.14	0.07	0.45	0.41	0.34	0.00	0.00	0.00	0.26	0.22	0.14	0.38	0.20	0.09	1.16	0.94	0.52	2.13	2.19	1.82	0.08	0.16	0.22	0.00	0.34	0.14	1.47	1.49	1.00	2.26	2.16	1.56	0.12	0.00	0.00	0.00	0.09	0.00	0.02	0.00	0.04	0.49	0.40	0.42	0.00	0.30	0.08	0.19	0.00	0.00	0.05	0.19	0.08	0.58	0.68	0.70	0.14	0.09	0.06	0.01	0.25	0.08	0.00	0.00	0.00	0.13	0.09	0.08	0.14	0.07	0.10	0.68	1.14	0.73	3.16	4.08	3.04	0.10	0.14	0.10	0.16	0.07	0.00	0.87	1.02	1.90	2.68	2.49	3.28	0.11	0.14	0.14	0.05	0.02	0.00	0.10	0.11	0.10	0.91	0.86	0.91	0.11	0.07	0.07	0.05	0.03	0.08	0.09	0.10	0.11	1.01	1.17	1.14
Malate M+4	0.05	0.26	0.04	0.11	0.13	0.00	0.00	0.00	0.00	0.04	0.04	0.05	0.12	0.00	0.02	3.34	3.03	2.78	12.25	12.80	15.44	0.11	0.21	0.00	0.06	0.05	0.04	5.16	5.57	7.28	12.17	12.63	15.22	0.00	0.04	0.12	0.05	0.02	0.12	0.07	0.09	0.09	0.00	0.00	0.00	0.02	0.00	0.05	0.00	0.26	0.18	0.11	0.08	0.23	0.03	0.02	0.01	0.32	0.33	0.09	0.25	0.15	0.16	0.00	0.00	0.00	0.14	0.08	0.02	0.08	0.10	0.10	3.40	5.78	4.58	16.69	20.90	20.87	0.10	0.07	0.10	0.09	0.10	0.12	5.08	5.42	9.30	15.21	15.67	19.12	0.02	0.12	0.10	0.16	0.16	0.20	0.18	0.13	0.15	0.00	0.00	0.00	0.02	0.05	0.09	0.09	0.14	0.05	0.11	0.05	0.04	0.00	0.00	0.00
Malate M+5	0.02	0.04	0.00	0.19	0.94	0.00	0.06	0.07	0.11	0.16	0.08	0.05	0.07	0.26	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.62	0.26	0.07	0.24	0.13	0.02	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.00	0.00	0.02	0.02	0.00	0.01	0.04	0.03	0.14	0.15	0.04	0.00	0.01	0.04	0.04	0.06	0.00	0.02	0.00	0.06	0.01	0.12	0.43	0.10	0.05	0.34	0.40	0.31	0.19	0.41	0.11	0.22	0.09	0.14	0.26	0.09	0.08	0.00	0.00	0.00	0.00	0.00	0.00	0.38	0.51	0.33	0.36	0.59	0.23	0.00	0.11	0.00	0.00	0.00	0.00	0.19	0.05	0.27	0.13	0.13	0.11	0.02	0.02	0.00	0.08	0.09	0.03	0.15	0.07	0.08	0.12	0.08	0.12	0.01	0.02	0.01	0.14	0.10	0.12
Lactate M0	98.06	98.42	94.49	97.16	97.79	98.73	99.97	99.69	99.97	99.00	99.03	95.93	94.54	95.29	97.88	98.78	98.73	95.03	99.58	99.57	99.34	96.47	98.89	98.64	97.12	97.85	98.77	98.38	98.00	94.86	99.39	99.36	99.51	99.82	99.83	99.81	99.92	99.92	97.98	96.55	97.32	99.98	99.83	99.82	97.05	99.44	99.47	99.71	98.54	99.92	99.94	99.21	99.95	99.93	99.72	99.75	96.77	98.77	99.34	97.78	99.71	99.99	99.58	99.90	99.94	99.95	99.37	99.33	99.10	99.82	99.47	99.40	98.72	98.25	98.81	99.49	98.62	99.50	99.99	99.34	99.98	99.95	99.84	99.98	98.26	97.04	98.84	99.59	99.61	98.46	98.34	98.98	98.73	98.62	98.51	98.95	90.75	89.94	90.26	83.33	82.20	81.28	99.04	99.00	98.93	99.03	99.14	99.30	88.90	89.80	89.13	84.07	82.98	82.82
Lactate M+1	1.60	1.35	4.44	2.29	1.79	1.13	0.00	0.26	0.00	0.88	0.85	3.26	4.45	3.82	1.74	1.00	1.06	3.99	0.00	0.00	0.45	2.83	0.96	1.13	2.31	1.79	1.03	1.18	1.56	4.04	0.24	0.29	0.16	0.00	0.00	0.00	0.00	0.00	1.59	2.83	2.18	0.00	0.00	0.00	2.35	0.00	0.00	0.00	1.14	0.00	0.00	0.60	0.05	0.00	0.00	0.00	2.40	0.99	0.48	1.78	0.19	0.00	0.27	0.00	0.00	0.00	0.47	0.51	0.72	0.16	0.40	0.44	0.84	0.98	0.62	0.09	0.68	0.00	0.00	0.48	0.00	0.00	0.13	0.00	1.06	2.11	0.29	0.00	0.00	0.61	1.28	0.80	0.99	1.03	1.14	0.79	1.28	1.55	1.43	0.81	0.81	0.78	0.71	0.76	0.83	0.75	0.65	0.56	1.68	1.49	1.59	0.76	0.82	0.78
Lactate M+2	0.34	0.23	1.05	0.55	0.41	0.14	0.00	0.00	0.00	0.12	0.11	0.80	1.00	0.88	0.38	0.19	0.17	0.97	0.00	0.04	0.07	0.69	0.16	0.23	0.57	0.36	0.20	0.29	0.32	1.08	0.00	0.01	0.04	0.00	0.00	0.00	0.00	0.00	0.42	0.61	0.49	0.01	0.00	0.00	0.59	0.00	0.00	0.00	0.32	0.00	0.00	0.19	0.00	0.00	0.00	0.00	0.69	0.23	0.17	0.43	0.09	0.00	0.14	0.00	0.00	0.00	0.16	0.15	0.18	0.00	0.13	0.16	0.27	0.41	0.22	0.11	0.28	0.00	0.00	0.17	0.00	0.00	0.03	0.00	0.40	0.60	0.20	0.00	0.00	0.34	0.38	0.21	0.28	0.35	0.35	0.26	0.98	1.09	1.09	1.46	1.49	1.56	0.24	0.24	0.24	0.21	0.20	0.15	1.33	1.21	1.26	1.60	1.67	1.56
Lactate M+3	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.00	0.00	0.00	0.00	0.00	0.00	0.03	0.05	0.00	0.40	0.36	0.13	0.00	0.00	0.00	0.00	0.00	0.00	0.14	0.11	0.01	0.33	0.31	0.26	0.15	0.12	0.16	0.08	0.07	0.00	0.00	0.00	0.00	0.17	0.18	0.00	0.55	0.51	0.28	0.00	0.07	0.06	0.00	0.00	0.07	0.28	0.25	0.12	0.00	0.00	0.00	0.00	0.00	0.00	0.09	0.05	0.05	0.00	0.00	0.00	0.00	0.00	0.00	0.17	0.36	0.35	0.31	0.43	0.50	0.00	0.00	0.01	0.04	0.00	0.02	0.28	0.24	0.67	0.41	0.39	0.59	0.00	0.00	0.00	0.00	0.00	0.00	6.98	7.41	7.21	14.40	15.50	16.38	0.00	0.00	0.00	0.00	0.00	0.00	8.09	7.50	8.02	13.57	14.53	14.84
Lactate M+4	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.04	0.02	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.01	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.05	0.03	0.03	0.03	0.05	0.02	0.01	0.01	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.01	0.00	0.01	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.01	0.00	0.01	0.01	0.00	0.00	0.00	0.00	0.01	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Alanine M0	99.15	99.43	99.66	99.55	99.26	99.78	99.41	99.53	99.77	99.05	99.01	99.52	99.13	99.14	99.90	99.10	99.04	99.50	99.46	99.43	99.34	99.30	99.25	99.71	99.38	99.48	99.88	99.30	99.17	99.29	99.27	99.30	99.10	99.99	99.98	99.98	99.98	99.99	100.00	99.55	98.67	98.74	98.71	96.48	96.51	99.97	99.98	99.99	99.99	99.98	99.99	98.57	98.47	98.47	97.69	97.51	97.24	99.61	99.94	99.96	99.86	99.89	99.85	99.96	98.90	99.21	99.93	99.95	99.98	99.87	99.96	99.95	99.65	99.54	99.66	98.42	97.01	98.79	99.74	99.77	99.96	99.97	99.87	99.97	99.40	99.39	99.29	99.25	98.94	96.87	99.98	99.97	99.97	99.97	99.96	99.97	96.22	95.82	95.97	90.47	90.03	89.97	99.98	99.97	99.99	99.97	99.98	99.99	95.99	96.31	96.00	92.47	92.39	92.39
Alanine M+1	0.62	0.39	0.21	0.26	0.58	0.12	0.41	0.36	0.14	0.72	0.79	0.30	0.69	0.70	0.00	0.62	0.68	0.34	0.26	0.25	0.32	0.44	0.52	0.15	0.37	0.35	0.02	0.43	0.60	0.37	0.35	0.35	0.50	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.04	0.00	0.00	0.42	0.37	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.29	0.02	0.00	0.10	0.05	0.12	0.02	0.87	0.65	0.03	0.00	0.00	0.07	0.00	0.00	0.16	0.00	0.00	1.00	1.85	0.56	0.18	0.19	0.00	0.00	0.10	0.00	0.28	0.29	0.00	0.30	0.55	1.86	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.60	1.66	1.67	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.08	1.07	1.06
Alanine M+2	0.22	0.17	0.12	0.19	0.15	0.09	0.17	0.10	0.08	0.22	0.20	0.17	0.18	0.15	0.09	0.28	0.28	0.15	0.26	0.30	0.33	0.25	0.22	0.13	0.24	0.17	0.10	0.27	0.22	0.33	0.37	0.34	0.39	0.00	0.02	0.00	0.00	0.00	0.00	0.44	1.29	1.26	1.29	3.09	3.12	0.00	0.00	0.00	0.00	0.00	0.00	1.43	1.53	1.53	2.31	2.48	2.75	0.10	0.04	0.03	0.04	0.06	0.03	0.00	0.23	0.14	0.03	0.03	0.01	0.06	0.00	0.03	0.18	0.46	0.32	0.57	1.13	0.64	0.08	0.04	0.01	0.02	0.03	0.01	0.32	0.32	0.71	0.45	0.51	1.26	0.00	0.00	0.00	0.00	0.02	0.01	3.77	4.18	4.02	7.92	8.31	8.35	0.01	0.02	0.00	0.00	0.00	0.00	4.01	3.69	4.00	6.44	6.53	6.54
Alanine M+3	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.02	0.02	0.01	0.00	0.01	0.00	0.00	0.00	0.00	0.00	0.03	0.01	0.01	0.01	0.01	0.01	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.00	0.00	0.01	0.00	0.00	0.00	0.02	0.01	0.00	0.04	0.02	0.00	0.00	0.01	0.00	0.00	0.00	0.00	0.00	0.03	0.00	0.00	0.03	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.02	0.02	0.03	0.01	0.03	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.01	0.01	0.03	0.02	0.01	0.00	0.00	0.00	0.00	0.00	0.00
Aspartate M0	99.10	99.45	99.30	99.64	99.50	99.49	97.36	97.51	99.04	99.46	99.53	98.61	99.43	99.65	99.02	96.12	95.26	79.80	79.77	78.28	70.52	99.57	99.53	99.42	99.75	99.47	99.56	90.82	90.52	73.16	77.58	76.78	69.09	99.81	99.66	99.50	99.33	99.29	99.14	98.78	96.94	94.78	96.56	93.70	93.40	99.30	99.28	99.26	99.19	99.17	99.15	95.92	96.26	96.59	92.56	92.27	92.13	94.55	91.17	96.51	96.48	95.39	93.94	99.40	99.36	98.82	90.61	92.70	95.78	96.61	96.73	96.26	66.89	54.58	61.70	70.26	61.08	60.99	93.27	92.35	88.80	97.42	96.49	97.38	77.44	74.87	45.99	72.97	72.66	65.54	96.83	95.15	99.23	99.17	99.23	99.16	98.92	96.70	98.14	94.47	94.03	94.14	99.37	99.31	99.35	99.65	99.35	99.65	92.06	92.46	98.47	93.23	93.54	93.28
Aspartate M+1	0.74	0.23	0.36	0.10	0.19	0.00	2.17	2.01	0.80	0.30	0.16	0.48	0.33	0.07	0.00	0.37	0.13	2.86	2.52	3.00	6.00	0.00	0.28	0.00	0.08	0.35	0.00	1.04	0.96	4.18	3.60	3.78	6.59	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.12	0.69	2.98	3.11	0.00	0.00	0.00	0.00	0.00	0.00	0.49	0.58	0.22	2.62	2.90	2.97	2.38	4.33	2.77	0.00	0.76	0.00	0.58	0.61	1.06	0.00	0.00	0.75	0.42	0.00	0.36	2.36	5.87	2.76	4.22	5.99	5.97	0.38	0.72	0.00	0.02	0.02	0.14	0.00	0.00	0.14	4.01	3.91	5.51	2.31	3.95	0.00	0.00	0.14	0.00	0.27	2.43	1.04	1.96	2.33	2.21	0.08	0.00	0.00	0.00	0.00	0.00	5.44	6.52	0.88	2.48	2.22	2.41
Aspartate M+2	0.13	0.29	0.08	0.18	0.19	0.06	0.46	0.46	0.15	0.00	0.00	0.00	0.00	0.08	0.08	0.50	0.86	4.87	3.93	4.20	7.50	0.22	0.04	0.04	0.00	0.04	0.00	1.65	1.93	6.92	4.81	5.01	8.42	0.00	0.13	0.00	0.11	0.00	0.00	0.33	0.19	1.28	2.34	3.03	3.14	0.00	0.00	0.00	0.00	0.00	0.00	1.85	1.36	1.64	4.27	4.32	4.32	0.09	0.00	0.00	0.02	0.00	0.00	0.00	0.03	0.12	0.15	0.00	0.00	0.00	0.00	0.21	2.55	0.98	4.83	6.84	9.46	9.39	0.00	0.00	0.00	0.06	0.00	0.00	2.39	3.13	5.03	6.32	6.26	8.32	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	2.83	2.89	2.84	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	3.46	3.28	3.41
Aspartate M+3	0.00	0.00	0.17	0.06	0.10	0.41	0.00	0.00	0.00	0.21	0.26	0.82	0.19	0.18	0.80	0.80	0.90	3.36	2.14	2.18	1.67	0.20	0.13	0.50	0.15	0.12	0.40	1.35	1.27	2.81	2.12	2.07	1.68	0.12	0.15	0.43	0.26	0.53	0.49	0.87	2.23	2.21	0.34	0.28	0.35	0.64	0.72	0.71	0.66	0.75	0.79	1.51	1.37	1.41	0.52	0.40	0.54	0.39	1.97	0.00	3.49	3.85	6.06	0.00	0.00	0.00	9.24	0.00	3.47	2.97	3.27	3.17	18.37	20.97	15.16	2.98	3.69	2.91	6.35	6.93	10.94	2.50	3.49	2.37	10.07	11.37	42.62	2.50	2.37	2.88	0.00	0.00	0.00	0.70	0.49	0.70	0.00	0.00	0.00	0.73	0.74	0.80	0.35	0.57	0.52	0.19	0.50	0.20	2.43	0.93	0.50	0.84	0.94	0.90
Aspartate M+4	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	2.21	2.84	9.10	11.64	12.35	14.29	0.00	0.00	0.00	0.00	0.00	0.00	5.14	5.32	12.93	11.90	12.35	14.22	0.07	0.05	0.07	0.30	0.18	0.37	0.00	0.64	0.60	0.06	0.01	0.00	0.06	0.00	0.00	0.00	0.00	0.06	0.23	0.43	0.14	0.02	0.07	0.02	2.59	1.62	0.48	0.00	0.00	0.00	0.02	0.00	0.00	0.00	7.30	0.00	0.00	0.00	0.00	9.26	12.25	14.68	15.70	19.79	20.74	0.00	0.00	0.27	0.00	0.00	0.11	9.29	10.63	6.22	14.20	14.80	17.75	0.58	0.60	0.47	0.00	0.00	0.00	0.48	0.60	0.51	0.00	0.00	0.00	0.20	0.11	0.13	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.00
Aspartate M+5	0.04	0.02	0.09	0.02	0.02	0.03	0.01	0.02	0.00	0.03	0.04	0.09	0.04	0.02	0.10	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.02	0.03	0.02	0.02	0.04	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.15	0.08	0.00	0.00	0.00	0.00	0.02	0.04	0.01	0.00	0.91	0.23	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.57	5.35	0.87	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.81	0.00	0.00	0.00	0.00	0.00	0.28	0.30	0.30	0.13	0.14	0.13	0.32	0.27	0.32	0.01	0.00	0.00	0.00	0.00	0.00	0.16	0.15	0.16	0.08	0.09	0.15	0.00	0.00	0.00
Glutamate M0	99.68	99.75	99.90	99.85	99.84	99.92	99.37	99.59	99.42	99.96	99.84	99.75	99.84	99.75	99.77	94.29	93.57	77.95	78.17	76.66	66.75	99.93	99.53	99.62	99.84	99.79	99.74	89.45	88.39	70.03	76.62	76.01	65.34	99.39	99.36	99.47	99.61	99.25	98.65	98.27	95.72	94.22	93.24	91.29	90.56	99.08	98.84	99.23	98.69	98.90	99.57	95.46	95.95	95.99	90.83	90.75	90.80	99.13	99.24	99.49	99.68	99.58	99.69	98.43	98.88	98.81	99.54	99.60	99.83	99.36	96.67	99.69	70.97	57.96	66.25	65.90	54.83	56.23	99.69	99.69	98.58	99.61	99.49	98.63	74.18	71.41	59.78	68.14	67.61	58.81	99.68	99.63	99.57	99.25	99.51	99.58	94.93	94.49	93.58	93.41	93.06	93.50	99.63	99.64	99.54	99.69	99.72	99.58	93.85	94.32	93.21	92.33	92.51	92.36
Glutamate M+1	0.00	0.00	0.00	0.00	0.00	0.00	0.46	0.34	0.54	0.00	0.00	0.00	0.00	0.00	0.00	0.45	0.12	1.99	1.31	1.47	3.80	0.00	0.41	0.24	0.00	0.00	0.13	0.17	0.40	3.45	1.72	1.75	4.83	0.58	0.61	0.26	0.33	0.30	0.90	0.57	1.50	2.32	2.97	4.07	4.50	0.88	1.11	0.72	1.24	1.02	0.29	1.77	1.35	1.29	3.24	3.28	3.29	0.00	0.00	0.00	0.00	0.00	0.00	1.49	1.09	1.13	0.00	0.00	0.00	0.00	2.18	0.00	1.24	2.94	1.29	3.07	4.44	4.16	0.00	0.00	1.08	0.00	0.00	0.32	0.75	0.90	2.73	3.25	3.28	4.09	0.15	0.19	0.23	0.38	0.12	0.00	1.13	0.93	1.16	2.35	2.46	2.24	0.30	0.25	0.33	0.17	0.10	0.25	2.07	1.69	1.58	2.57	2.67	2.61
Glutamate M+2	0.00	0.00	0.00	0.03	0.00	0.00	0.16	0.03	0.01	0.00	0.00	0.24	0.00	0.16	0.06	0.04	0.42	1.13	1.10	1.12	2.38	0.00	0.00	0.00	0.00	0.00	0.00	0.51	0.53	2.03	1.44	1.38	2.91	0.01	0.01	0.24	0.04	0.13	0.19	1.10	2.01	2.37	3.76	4.58	4.89	0.00	0.00	0.02	0.01	0.00	0.04	2.61	2.40	2.54	5.62	5.69	5.65	0.00	0.00	0.24	0.00	0.15	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.16	0.71	2.24	1.61	1.91	3.24	2.69	0.00	0.00	0.00	0.00	0.00	0.00	1.11	1.18	2.29	1.75	1.82	2.89	0.01	0.06	0.13	0.10	0.00	0.06	2.89	3.25	3.12	4.10	4.32	4.13	0.07	0.09	0.11	0.07	0.10	0.09	2.63	3.02	3.19	4.89	4.66	4.83
Glutamate M+3	0.18	0.20	0.00	0.11	0.15	0.04	0.00	0.04	0.02	0.04	0.16	0.00	0.09	0.00	0.00	0.70	0.92	4.91	3.73	3.94	7.23	0.07	0.06	0.14	0.06	0.12	0.05	1.72	1.77	6.53	4.34	4.40	8.24	0.00	0.00	0.00	0.01	0.28	0.23	0.01	0.73	1.02	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.03	0.08	0.04	0.22	0.11	0.21	0.15	0.13	0.49	0.36	0.18	0.32	0.27	0.31	0.05	0.00	0.00	0.46	0.36	0.17	0.28	0.22	0.09	5.62	7.54	6.68	7.59	10.77	10.36	0.31	0.31	0.30	0.18	0.23	0.51	4.80	5.77	6.94	7.51	7.14	9.37	0.10	0.05	0.00	0.25	0.32	0.24	0.92	0.96	1.98	0.10	0.11	0.09	0.00	0.01	0.02	0.07	0.08	0.08	1.38	0.93	2.02	0.14	0.11	0.13
Glutamate M+4	0.00	0.00	0.10	0.00	0.00	0.04	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.00	0.17	0.08	0.28	0.45	0.48	0.60	0.00	0.00	0.00	0.02	0.02	0.04	0.31	0.31	0.66	0.42	0.45	0.60	0.02	0.02	0.01	0.01	0.04	0.02	0.05	0.00	0.06	0.01	0.05	0.04	0.03	0.03	0.01	0.03	0.02	0.01	0.10	0.07	0.06	0.09	0.11	0.10	0.00	0.00	0.00	0.00	0.00	0.00	0.03	0.03	0.06	0.00	0.00	0.00	0.00	0.01	0.00	0.81	1.07	1.05	0.83	1.09	1.10	0.00	0.00	0.03	0.00	0.01	0.07	0.62	0.69	1.03	0.67	0.70	1.00	0.06	0.08	0.06	0.01	0.04	0.11	0.14	0.37	0.15	0.03	0.04	0.03	0.00	0.00	0.00	0.00	0.00	0.00	0.07	0.03	0.00	0.07	0.05	0.07
Glutamate M+5	0.14	0.06	0.00	0.00	0.01	0.00	0.01	0.00	0.01	0.00	0.00	0.01	0.07	0.06	0.17	4.34	4.89	13.73	15.23	16.33	19.24	0.00	0.00	0.00	0.08	0.06	0.05	7.83	8.60	17.30	15.46	16.02	18.08	0.00	0.00	0.02	0.00	0.00	0.01	0.00	0.04	0.00	0.01	0.01	0.01	0.00	0.01	0.01	0.02	0.03	0.01	0.01	0.01	0.01	0.01	0.01	0.02	0.38	0.40	0.09	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.04	0.00	0.36	0.92	0.06	20.64	28.26	23.12	20.70	25.62	25.47	0.00	0.00	0.00	0.21	0.27	0.47	18.54	20.05	27.22	18.68	19.45	23.84	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Glutamate M+6	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Glutamine M0	99.37	99.30	98.29	99.71	99.38	96.95	97.26	97.89	98.34	97.74	98.64	98.70	69.69	69.60	46.65	70.27	69.46	51.30	72.21	71.51	54.44	98.68	97.78	99.43	66.46	67.16	52.85	70.28	70.18	58.53	71.24	71.06	55.81	99.98	98.56	99.84	96.47	99.23	99.15	99.46	99.71	99.35	99.57	98.66	98.09	99.91	99.43	99.51	99.81	98.97	98.38	99.13	99.71	99.75	99.48	99.70	99.65	99.76	99.68	98.83	99.97	99.91	99.84	99.11	98.11	99.57	99.88	99.72	99.73	60.58	46.55	47.98	61.67	52.07	52.80	62.23	49.93	51.09	99.69	99.60	99.33	65.49	62.94	50.20	65.49	65.92	56.38	65.05	65.01	55.16	99.88	99.86	99.91	99.77	99.82	99.80	99.45	99.65	99.15	95.73	94.74	94.14	99.92	99.91	99.91	99.92	99.91	99.93	99.00	99.50	99.36	96.63	97.16	96.75
Glutamine M+1	0.00	0.00	0.00	0.17	0.00	0.00	2.31	1.93	1.53	1.62	0.00	0.00	0.27	0.21	0.46	1.83	1.41	0.65	0.94	0.91	1.00	0.45	0.73	0.00	0.00	0.69	0.00	0.00	0.03	0.00	0.60	0.92	0.88	0.00	0.00	0.00	1.85	0.00	0.00	0.00	0.00	0.63	0.24	0.68	1.11	0.00	0.07	0.14	0.00	0.00	1.59	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.76	1.53	0.37	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.00	1.44	1.16	0.00	0.00	0.00	0.00	0.00	1.79	0.00	0.00	0.47	0.95	0.96	1.89	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	2.14	2.91	3.41	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.54	1.16	1.50
Glutamine M+2	0.53	0.55	1.68	0.00	0.56	0.00	0.38	0.14	0.09	0.54	1.32	1.19	0.96	0.39	0.89	0.32	1.46	1.17	0.02	0.25	0.27	0.76	1.31	0.50	2.29	1.51	0.16	1.29	0.53	0.00	0.32	0.23	0.28	0.00	0.94	0.00	1.66	0.71	0.76	0.43	0.00	0.00	0.17	0.64	0.78	0.09	0.00	0.00	0.00	0.90	0.00	0.00	0.00	0.00	0.51	0.21	0.27	0.00	0.00	0.69	0.00	0.07	0.00	0.13	0.35	0.04	0.05	0.00	0.00	0.31	0.00	0.18	0.36	0.53	0.52	0.41	0.91	0.44	0.00	0.30	0.46	0.00	0.22	0.00	0.29	0.28	0.61	0.56	0.38	1.09	0.00	0.00	0.00	0.05	0.05	0.00	0.53	0.00	0.65	2.11	2.33	2.42	0.00	0.00	0.00	0.00	0.00	0.03	0.90	0.39	0.58	1.82	1.66	1.72
Glutamine M+3	0.07	0.11	0.00	0.00	0.00	2.91	0.00	0.00	0.00	0.00	0.00	0.03	0.00	0.00	0.00	0.00	0.00	0.00	0.16	0.03	0.22	0.00	0.00	0.00	0.00	0.00	0.10	0.00	0.03	0.41	0.15	0.14	0.32	0.00	0.47	0.16	0.00	0.01	0.00	0.00	0.28	0.00	0.00	0.00	0.00	0.00	0.49	0.34	0.17	0.03	0.00	0.85	0.28	0.25	0.00	0.09	0.08	0.14	0.10	0.44	0.03	0.02	0.12	0.00	0.00	0.00	0.03	0.24	0.25	0.00	0.30	0.20	0.51	1.17	0.21	1.10	3.17	1.46	0.22	0.03	0.17	0.20	0.05	0.09	0.59	0.69	1.94	1.32	1.31	3.77	0.11	0.10	0.07	0.14	0.07	0.16	0.00	0.30	0.15	0.00	0.00	0.00	0.02	0.05	0.04	0.04	0.04	0.02	0.04	0.10	0.06	0.00	0.00	0.00
Glutamine M+4	0.00	0.00	0.00	0.06	0.02	0.00	0.00	0.01	0.00	0.02	0.00	0.00	1.00	1.06	2.21	1.03	0.93	1.92	1.00	1.02	1.88	0.00	0.00	0.00	1.10	1.15	1.80	0.94	1.01	1.62	1.02	1.03	1.82	0.02	0.00	0.00	0.00	0.00	0.07	0.09	0.00	0.01	0.02	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.00	0.00	0.00	0.01	0.00	0.00	0.02	0.00	0.00	0.00	1.77	2.48	2.40	1.55	2.33	2.37	1.41	2.00	2.15	0.00	0.00	0.00	1.45	1.59	2.41	1.42	1.45	1.88	1.30	1.32	1.60	0.01	0.02	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.00	0.00	0.06	0.00	0.00	0.00	0.01	0.01
Glutamine M+5	0.04	0.03	0.00	0.06	0.03	0.02	0.04	0.03	0.03	0.07	0.04	0.08	28.03	28.63	49.59	26.42	26.67	44.96	25.62	26.27	42.19	0.04	0.11	0.07	30.15	29.48	45.09	27.49	28.22	39.44	26.67	26.62	40.88	0.00	0.00	0.00	0.00	0.00	0.02	0.03	0.00	0.00	0.00	0.02	0.02	0.00	0.00	0.00	0.02	0.10	0.03	0.00	0.01	0.00	0.01	0.00	0.00	0.08	0.22	0.05	0.00	0.00	0.00	0.00	0.01	0.00	0.01	0.04	0.01	37.34	50.66	49.14	35.91	43.90	44.09	33.82	42.46	43.64	0.04	0.04	0.04	32.78	35.11	45.26	32.05	31.48	38.48	30.78	31.01	36.43	0.00	0.00	0.00	0.04	0.06	0.04	0.01	0.05	0.04	0.02	0.02	0.02	0.00	0.01	0.00	0.04	0.05	0.02	0.00	0.00	0.00	0.01	0.01	0.02
Glutamine M+6	0.00	0.00	0.02	0.00	0.00	0.11	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.06	0.06	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.00	0.02	0.04	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.00	0.00	0.00	0.02	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.04	0.04	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.02	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.06	0.04	0.04	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Glutamine M+7	0.00	0.01	0.01	0.01	0.01	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.06	0.11	0.20	0.13	0.07	0.00	0.04	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.00	0.00	0.00	0.01	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.10	0.00	0.00	0.00	0.03	0.08	0.06	0.00	0.00	0.00	0.08	0.09	0.25	0.17	0.18	0.24	0.03	0.01	0.05	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.00	0.00	0.00	0.00	0.00
2-Hydroxyglutarate M0	88.59	92.93	90.30	90.00	92.86	87.87	97.86	97.89	87.43	89.79	90.96	91.88	90.95	93.94	91.56	93.19	94.24	90.74	90.00	86.84	81.80	92.99	94.73	95.54	89.05	91.96	91.88	90.45	91.28	94.36	86.45	84.91	75.69	96.60	94.51	96.52	92.58	92.40	90.05	91.18	93.97	89.55	94.88	93.25	94.70	92.76	91.44	92.03	91.93	88.80	91.50	91.68	90.05	88.40	92.38	89.52	88.97	92.40	92.76	95.52	92.37	93.63	94.43	98.59	97.12	97.19	93.67	92.93	94.20	93.14	91.70	93.58	91.14	88.58	90.36	71.20	55.41	66.10	94.50	94.01	94.20	95.62	95.12	93.51	91.92	89.57	86.53	74.42	72.83	60.11	87.73	86.24	89.69	89.87	87.78	86.95	86.75	88.74	83.27	89.35	88.15	90.29	84.94	86.83	88.55	87.92	87.63	89.22	88.76	90.76	86.95	76.56	82.12	83.72
2-Hydroxyglutarate M+1	4.34	1.36	3.99	4.40	1.77	6.90	0.00	0.00	0.00	4.77	3.15	3.77	4.68	1.85	4.95	1.27	1.49	5.37	0.00	0.00	1.14	3.64	1.34	1.26	7.45	3.99	5.03	4.91	4.35	0.93	0.48	0.00	2.02	0.00	1.14	0.00	3.71	3.62	2.89	2.34	0.00	2.53	0.46	1.43	0.82	0.00	1.21	0.00	0.18	4.37	1.18	1.56	2.10	1.30	2.34	3.86	3.06	3.93	2.03	0.00	3.05	2.42	1.52	0.00	1.55	1.57	1.35	3.61	2.70	3.01	4.46	3.18	3.05	3.14	3.18	4.02	3.71	3.51	2.98	3.53	2.44	1.44	2.17	4.28	1.10	4.37	2.49	2.38	2.82	4.43	1.97	1.47	1.89	3.47	3.72	1.84	0.24	0.91	0.89	0.90	0.75	0.00	1.57	1.19	0.62	3.39	2.08	3.36	0.61	0.81	2.10	1.33	1.43	0.57
2-Hydroxyglutarate M+2	0.00	0.26	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.15	0.00	0.19	0.00	0.00	0.23	0.22	0.64	0.00	0.00	0.77	0.00	0.00	0.00	0.00	0.00	0.00	0.37	0.59	1.39	0.00	0.00	0.00	0.00	1.15	1.63	0.00	0.00	0.83	1.15	3.04	2.81	0.00	0.27	0.00	1.59	0.27	0.00	0.00	0.00	0.00	2.55	5.14	5.05	0.00	0.00	0.42	0.00	0.00	0.00	0.61	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.57	2.91	2.27	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.55	1.79	2.86	0.00	0.03	0.00	0.00	0.00	0.00	1.78	0.15	1.92	3.44	3.59	4.09	0.25	0.00	0.24	0.00	0.10	0.00	1.65	0.58	0.49	3.41	3.45	3.77
2-Hydroxyglutarate M+3	1.62	0.81	1.63	1.29	1.36	1.49	0.29	0.34	0.36	0.81	1.50	0.84	1.15	0.63	0.54	1.33	1.32	1.04	2.32	2.85	4.34	0.25	0.31	0.28	0.66	0.98	0.80	0.99	1.29	1.31	3.26	3.53	5.22	1.56	1.56	1.81	0.55	1.20	1.98	2.83	1.49	2.26	0.87	0.43	0.33	1.63	0.49	1.70	0.91	1.29	0.57	0.56	0.53	2.53	1.48	0.00	0.00	0.81	1.40	0.65	1.10	1.21	1.15	0.00	0.00	0.01	1.25	1.10	0.89	0.58	0.75	0.65	1.07	2.03	1.68	6.25	8.07	7.71	0.40	0.59	0.83	0.95	0.50	0.21	1.81	1.04	2.42	5.69	5.68	7.78	0.99	1.53	1.57	0.85	1.15	1.66	1.90	1.16	1.73	0.07	0.11	0.01	1.30	1.70	1.77	1.08	1.76	0.94	0.95	1.06	1.78	0.02	0.18	0.32
2-Hydroxyglutarate M+4	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.02	0.00	0.00	0.01	0.00	0.00	0.03	0.00	0.00	0.01	0.03	0.13	0.06	0.00	0.06	0.00	0.11	0.00	0.34	0.00	0.00	0.00	0.13	0.00	0.05	0.00	0.52	0.00	0.41	0.34	0.09	0.14	0.91	0.60	0.28	0.21	0.21	0.39	0.45	0.21	0.00	0.77	0.95	0.85	0.97	0.88	0.18	0.61	0.04	0.29	0.20	0.26	0.32	0.35	0.31	0.00	0.00	0.00	0.52	0.27	0.32	0.35	0.48	0.37	0.35	0.28	0.23	0.43	0.86	0.83	0.26	0.31	0.19	0.32	0.26	0.46	0.27	0.54	0.53	0.52	0.35	0.69	1.30	1.27	0.97	0.80	1.03	1.45	1.12	1.53	1.70	0.18	0.12	0.09	1.67	1.50	1.18	1.14	1.00	1.09	1.16	0.76	0.86	0.18	0.21	0.15
2-Hydroxyglutarate M+5	4.98	4.42	4.08	4.26	4.02	3.74	0.24	0.18	0.18	4.06	3.48	3.18	3.03	2.90	2.47	3.11	2.49	2.19	7.14	8.99	8.68	2.22	2.25	1.49	2.07	2.35	1.45	2.75	2.22	2.90	9.13	9.71	10.16	1.84	2.28	1.67	2.15	1.28	3.35	3.51	3.31	4.22	2.31	1.41	0.84	4.74	6.14	5.76	5.40	4.50	5.80	5.20	6.36	6.91	1.07	0.86	1.60	2.56	3.60	3.14	2.96	2.29	2.59	0.76	0.64	0.50	3.21	2.04	1.89	2.92	2.60	2.19	4.38	5.97	4.54	16.28	21.23	18.27	1.85	1.50	2.33	1.67	1.83	1.54	4.88	4.47	8.04	14.93	15.06	19.99	8.00	9.32	5.81	4.83	6.18	7.95	8.21	7.51	10.45	0.00	0.01	0.02	10.22	8.78	7.63	6.46	7.24	5.38	6.83	5.97	7.82	0.02	0.00	0.00
2-Hydroxyglutarate M+6	0.00	0.00	0.00	0.02	0.00	0.00	0.02	0.01	0.08	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.03	0.00	0.00	0.06	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.09	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.04	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.12	0.16	0.11	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.41	0.34	0.31
2-Hydroxyglutarate M+7	0.47	0.22	0.00	0.03	0.00	0.00	1.59	1.57	11.93	0.57	0.91	0.31	0.19	0.53	0.45	0.90	0.47	0.65	0.29	0.97	3.34	0.90	1.30	0.64	0.66	0.72	0.45	0.90	0.85	0.49	0.18	1.26	5.46	0.00	0.00	0.00	0.61	0.00	0.00	0.00	0.32	0.00	0.05	0.23	0.20	0.48	0.00	0.30	0.00	0.00	0.00	0.15	0.00	0.00	0.00	0.00	1.24	0.00	0.00	0.00	0.19	0.08	0.00	0.03	0.69	0.73	0.00	0.07	0.00	0.00	0.00	0.03	0.00	0.00	0.00	0.26	7.81	1.31	0.00	0.06	0.00	0.00	0.12	0.00	0.01	0.00	0.00	0.51	1.46	4.15	0.02	0.15	0.07	0.18	0.14	0.15	0.00	0.00	0.04	5.94	7.12	5.39	0.04	0.00	0.00	0.00	0.19	0.00	0.04	0.06	0.00	18.06	12.26	11.15
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name
Citrate M0
Citrate M+1
Citrate M+2
Citrate M+3
Citrate M+4
Citrate M+5
Citrate M+6
Citrate M+7
Ketoglutarate M0
Ketoglutarate M+1
Ketoglutarate M+2
Ketoglutarate M+3
Ketoglutarate M+4
Ketoglutarate M+5
Ketoglutarate M+6
Succinate M0
Succinate M+1
Succinate M+2
Succinate M+3
Succinate M+4
Succinate M+5
Fumarate M0
Fumarate M+1
Fumarate M+2
Fumarate M+3
Fumarate M+4
Fumarate M+5
Malate M0
Malate M+1
Malate M+2
Malate M+3
Malate M+4
Malate M+5
Lactate M0
Lactate M+1
Lactate M+2
Lactate M+3
Lactate M+4
Alanine M0
Alanine M+1
Alanine M+2
Alanine M+3
Aspartate M0
Aspartate M+1
Aspartate M+2
Aspartate M+3
Aspartate M+4
Aspartate M+5
Glutamate M0
Glutamate M+1
Glutamate M+2
Glutamate M+3
Glutamate M+4
Glutamate M+5
Glutamate M+6
Glutamine M0
Glutamine M+1
Glutamine M+2
Glutamine M+3
Glutamine M+4
Glutamine M+5
Glutamine M+6
Glutamine M+7
2-Hydroxyglutarate M0
2-Hydroxyglutarate M+1
2-Hydroxyglutarate M+2
2-Hydroxyglutarate M+3
2-Hydroxyglutarate M+4
2-Hydroxyglutarate M+5
2-Hydroxyglutarate M+6
2-Hydroxyglutarate M+7
METABOLITES_END
#END