{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST003063","ANALYSIS_ID":"AN005018","VERSION":"1","CREATED_ON":"February 1, 2024, 11:07 am"},

"PROJECT":{"PROJECT_TITLE":"Uncoupling Metabolic Health from Thermogenesis via BCAA Nitrogen Flux in Brown Fat","PROJECT_SUMMARY":"Brown adipose tissue (BAT) is best known for its role in thermogenesis. While many studies in rodents have shown tight associations between the metabolic benefits of BAT and increased whole-body energy expenditure, recent evidence in humans suggests that BAT is protective against Type 2 diabetes independent of body-weight. The mechanism underlying this dissociation remains unclear. Here, we report that impaired mitochondrial catabolism of branched-chain amino acids (BCAA) in BAT, by deleting mitochondrial BCAA carrier (MBC, SLC25A44), sufficiently attenuated insulin sensitivity without affecting whole-body energy expenditure and body-weight. We found that brown adipocytes catabolized BCAA in the mitochondria as essential nitrogen donors for the biosynthesis of glutamate, alanine, N-acetyl amino acids, and one of the products, glutathione. On the other hand, the contribution of BCAA as a carbon source to the TCA cycle was incremental. Impairment of mitochondrial BCAA nitrogen flux in BAT resulted in increased oxidative stress and decreased insulin signaling in the liver, as well as decreased levels of BCAA-nitrogen derived metabolites in circulation. Notably, a high-fat diet rapidly impaired BCAA catabolism and the synthesis of BCAA-derived metabolites in the BAT, while cold-induced BAT activity is coupled with an active synthesis of these metabolites. Together, the present work uncovers a mechanism through which brown fat regulates metabolic health via BCAA-derived nitrogen carriers that act on the liver, independent of thermogenesis.","INSTITUTE":"BIDMC","LAST_NAME":"Wang","FIRST_NAME":"Dandan","ADDRESS":"3 Blackfan Circle, Boston, MA, 02115, USA","EMAIL":"dandanwang2022@gmail.com","PHONE":"5083733714"},

"STUDY":{"STUDY_TITLE":"Serum metabolomics from control and MBC UCP1-KO","STUDY_SUMMARY":"Targeted metabolomics in serum from high-fat diet fed control and MBCUCP1 KO mice. N = 6 for control and 7 for MBCUCP1 KO. Statistic: unpaired t-test. Data represented as z-score heatmap with each cell representing quantitated value for each mouse.","INSTITUTE":"BIDMC","LAST_NAME":"Wang","FIRST_NAME":"Dandan","ADDRESS":"3 Blackfan Circle, Boston, MA, 02115, USA","EMAIL":"dandanwang2022@gmail.com","PHONE":"5083733714"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"serum-Con-1",
"Factors":{"Genotype":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"serum-Con-1.d"}
},
{
"Subject ID":"-",
"Sample ID":"serum-Con-2",
"Factors":{"Genotype":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"serum-Con-2.d"}
},
{
"Subject ID":"-",
"Sample ID":"serum-Con-3",
"Factors":{"Genotype":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"serum-Con-3.d"}
},
{
"Subject ID":"-",
"Sample ID":"serum-Con-4",
"Factors":{"Genotype":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"serum-Con-4.d"}
},
{
"Subject ID":"-",
"Sample ID":"serum-Con-5",
"Factors":{"Genotype":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"serum-Con-5.d"}
},
{
"Subject ID":"-",
"Sample ID":"serum-Con-6",
"Factors":{"Genotype":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"serum-Con-6.d"}
},
{
"Subject ID":"-",
"Sample ID":"serum-KO-1",
"Factors":{"Genotype":"MBC UCP1-KO"},
"Additional sample data":{"RAW_FILE_NAME":"serum-KO-1.d"}
},
{
"Subject ID":"-",
"Sample ID":"serum-KO-2",
"Factors":{"Genotype":"MBC UCP1-KO"},
"Additional sample data":{"RAW_FILE_NAME":"serum-KO-2.d"}
},
{
"Subject ID":"-",
"Sample ID":"serum-KO-3",
"Factors":{"Genotype":"MBC UCP1-KO"},
"Additional sample data":{"RAW_FILE_NAME":"serum-KO-3.d"}
},
{
"Subject ID":"-",
"Sample ID":"serum-KO-4",
"Factors":{"Genotype":"MBC UCP1-KO"},
"Additional sample data":{"RAW_FILE_NAME":"serum-KO-4.d"}
},
{
"Subject ID":"-",
"Sample ID":"serum-KO-5",
"Factors":{"Genotype":"MBC UCP1-KO"},
"Additional sample data":{"RAW_FILE_NAME":"serum-KO-5.d"}
},
{
"Subject ID":"-",
"Sample ID":"serum-KO-6",
"Factors":{"Genotype":"MBC UCP1-KO"},
"Additional sample data":{"RAW_FILE_NAME":"serum-KO-6.d"}
},
{
"Subject ID":"-",
"Sample ID":"serum-KO-7",
"Factors":{"Genotype":"MBC UCP1-KO"},
"Additional sample data":{"RAW_FILE_NAME":"serum-KO-7.d"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Approximately 20 μL of blood was collected from the tail into tubes containing clotting activator (Starstedt Inc, 16.440.100). The blood samples were kept on ice and the serum was separated by centrifugation at 3,000 g for 10 min at 4 ˚C.","SAMPLE_TYPE":"Blood (serum)"},

"TREATMENT":{"TREATMENT_SUMMARY":"No treatment. All animal experiments conducted were performed in compliance of protocols approved by the Institutional Animal Care and Use Committee at Beth Israel Deaconess Medical Center (028-2022). All mice were housed under a 12 h – 12 h light/dark cycle. Room-temperature mice were housed at 23˚C in ventilated cages with an ACH of 25."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Serum metabolites were extracted using a 1:4 ratio of plasma to methanol extraction buffer. After centrifugation at 16,000 g for 15 minutes at 4°C, the supernatant was collected for LC-MS analysis."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Agilent 1260 Infinity HPLC","COLUMN_NAME":"Waters Atlantis Silica HILIC (150 x 2.1mm, 3um)","SOLVENT_A":"100% water; 10 mM ammonium formate and 0.1% formic acid","SOLVENT_B":"100% acetonitrile; 0.1% formic acid","FLOW_GRADIENT":"5% mobile phase A (10 mM ammonium formate and 0.1% formic acid in water) for 0.5 minute followed by a linear gradient to 40% mobile phase B (acetonitrile with 0.1% formic acid) over 10 minutes.","FLOW_RATE":"250 µL/min","COLUMN_TEMPERATURE":"25 °C"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"ABI Sciex 4000 QTrap","INSTRUMENT_TYPE":"QTRAP","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"MS analyses are carried out using electrospray ionization in the positive ion mode using scheduled MRM method. Multiquant software (version 3.0.3, Sciex) was used for automatic peak integration followed by manual review of all peaks for quality of integration."},

"MS_METABOLITE_DATA":{
"Units":"Peak area",

"Data":[{"Metabolite":"1,5-AG / 1-deoxyglucose","serum-Con-1":"20676.01874","serum-Con-2":"30173.16812","serum-Con-3":"25279.23383","serum-Con-4":"27893.29962","serum-Con-5":"31223.37037","serum-Con-6":"24662.64256","serum-KO-1":"30109.8992","serum-KO-2":"31619.83129","serum-KO-3":"27024.42063","serum-KO-4":"23054.20849","serum-KO-5":"30255.68644","serum-KO-6":"20483.97556","serum-KO-7":"27646.68802"},{"Metabolite":"11(12)-EET","serum-Con-1":"3289.286101","serum-Con-2":"1997.221519","serum-Con-3":"1118.026462","serum-Con-4":"8601.717221","serum-Con-5":"2341.796445","serum-Con-6":"2021.866966","serum-KO-1":"5207.207957","serum-KO-2":"1326.999327","serum-KO-3":"2565.394171","serum-KO-4":"1283.52144","serum-KO-5":"544.0073719","serum-KO-6":"863.67014","serum-KO-7":"958.6552856"},{"Metabolite":"12-Oxo-ETE","serum-Con-1":"1250.695931","serum-Con-2":"1417.161098","serum-Con-3":"1685.213272","serum-Con-4":"2736.055856","serum-Con-5":"1657.344566","serum-Con-6":"1021.051833","serum-KO-1":"3919.975572","serum-KO-2":"815.1423547","serum-KO-3":"1083.740227","serum-KO-4":"668.8145627","serum-KO-5":"732.1245009","serum-KO-6":"573.0260361","serum-KO-7":"662.1026311"},{"Metabolite":"14(15)-EET","serum-Con-1":"975.3384551","serum-Con-2":"565.7324378","serum-Con-3":"403.4570025","serum-Con-4":"1873.845226","serum-Con-5":"451.8096297","serum-Con-6":"353.8204057","serum-KO-1":"1098.289157","serum-KO-2":"380.5679104","serum-KO-3":"477.2311184","serum-KO-4":"338.9377549","serum-KO-5":"66.92004251","serum-KO-6":"280.9943229","serum-KO-7":"258.1727163"},{"Metabolite":"15-Oxo-ETE","serum-Con-1":"0","serum-Con-2":"0","serum-Con-3":"0","serum-Con-4":"0","serum-Con-5":"","serum-Con-6":"0","serum-KO-1":"","serum-KO-2":"0","serum-KO-3":"0","serum-KO-4":"","serum-KO-5":"","serum-KO-6":"","serum-KO-7":"0"},{"Metabolite":"20-Hydroxy-N-Arachidonoyl Taurine","serum-Con-1":"1622.592019","serum-Con-2":"1218.19089","serum-Con-3":"1181.185908","serum-Con-4":"969.8522229","serum-Con-5":"1360.014207","serum-Con-6":"1327.116125","serum-KO-1":"1731.63129","serum-KO-2":"2007.041333","serum-KO-3":"1387.153347","serum-KO-4":"1095.693821","serum-KO-5":"1204.412192","serum-KO-6":"1019.927881","serum-KO-7":"872.1683416"},{"Metabolite":"2-Aminoadipic acid","serum-Con-1":"7916.388295","serum-Con-2":"28552.04047","serum-Con-3":"16589.81368","serum-Con-4":"17168.35264","serum-Con-5":"17448.51475","serum-Con-6":"15455.98643","serum-KO-1":"19813.1722","serum-KO-2":"20208.69583","serum-KO-3":"16596.59065","serum-KO-4":"23335.15141","serum-KO-5":"22425.28299","serum-KO-6":"7043.388842","serum-KO-7":"18489.2085"},{"Metabolite":"2-Deoxyuridine","serum-Con-1":"13338.10906","serum-Con-2":"22251.77216","serum-Con-3":"23159.39288","serum-Con-4":"26155.40906","serum-Con-5":"30004.66061","serum-Con-6":"36669.53509","serum-KO-1":"25526.70013","serum-KO-2":"26407.83856","serum-KO-3":"21814.91202","serum-KO-4":"26967.12659","serum-KO-5":"30762.06111","serum-KO-6":"20759.74907","serum-KO-7":"30164.25497"},{"Metabolite":"2-Hydroxybutyric acid","serum-Con-1":"6219.057419","serum-Con-2":"13413.53904","serum-Con-3":"10735.67039","serum-Con-4":"7808.881098","serum-Con-5":"7763.009144","serum-Con-6":"9231.619093","serum-KO-1":"13272.52934","serum-KO-2":"12016.11534","serum-KO-3":"11491.40168","serum-KO-4":"12775.02002","serum-KO-5":"13932.8837","serum-KO-6":"10274.74727","serum-KO-7":"11270.082"},{"Metabolite":"2-Hydroxyglutaric acid","serum-Con-1":"340793.3794","serum-Con-2":"380598.6583","serum-Con-3":"289342.3876","serum-Con-4":"270413.1857","serum-Con-5":"276688.4723","serum-Con-6":"258649.3331","serum-KO-1":"334956.2522","serum-KO-2":"371319.0961","serum-KO-3":"286558.392","serum-KO-4":"239022.0558","serum-KO-5":"283899.7777","serum-KO-6":"236721.4183","serum-KO-7":"215586.9725"},{"Metabolite":"2-ketoisovaleric acid KIV","serum-Con-1":"9192.849861","serum-Con-2":"6520.930785","serum-Con-3":"6919.78518","serum-Con-4":"5392.203233","serum-Con-5":"7696.889149","serum-Con-6":"7834.658022","serum-KO-1":"6690.132853","serum-KO-2":"7652.917537","serum-KO-3":"7566.259754","serum-KO-4":"7886.362099","serum-KO-5":"7720.153621","serum-KO-6":"5797.976336","serum-KO-7":"5817.182901"},{"Metabolite":"3-Aminoisobutyric acid","serum-Con-1":"0","serum-Con-2":"0","serum-Con-3":"0","serum-Con-4":"0","serum-Con-5":"0","serum-Con-6":"","serum-KO-1":"0","serum-KO-2":"0","serum-KO-3":"0","serum-KO-4":"0","serum-KO-5":"0","serum-KO-6":"0","serum-KO-7":"0"},{"Metabolite":"3-Hydroxybutyric acid","serum-Con-1":"190134.3674","serum-Con-2":"183106.4238","serum-Con-3":"263170.1412","serum-Con-4":"92495.20497","serum-Con-5":"114600.7847","serum-Con-6":"82236.9591","serum-KO-1":"330009.0048","serum-KO-2":"490596.3946","serum-KO-3":"335351.5053","serum-KO-4":"264321.0742","serum-KO-5":"216964.816","serum-KO-6":"83992.46537","serum-KO-7":"207265.8841"},{"Metabolite":"5(6)-EET","serum-Con-1":"602.7955783","serum-Con-2":"420.7545436","serum-Con-3":"429.0733593","serum-Con-4":"844.7154061","serum-Con-5":"495.5982704","serum-Con-6":"221.6613463","serum-KO-1":"747.7336918","serum-KO-2":"467.357908","serum-KO-3":"396.6297565","serum-KO-4":"707.2876149","serum-KO-5":"484.4805183","serum-KO-6":"473.3836509","serum-KO-7":"373.3379104"},{"Metabolite":"5-MTHF","serum-Con-1":"2022.785749","serum-Con-2":"3478.403351","serum-Con-3":"3913.074624","serum-Con-4":"2891.188241","serum-Con-5":"3174.112421","serum-Con-6":"3115.247946","serum-KO-1":"1048.643989","serum-KO-2":"2088.48403","serum-KO-3":"2485.512912","serum-KO-4":"4312.411555","serum-KO-5":"4093.52906","serum-KO-6":"3973.404019","serum-KO-7":"3142.990904"},{"Metabolite":"5-Oxo-ETE","serum-Con-1":"1267.116285","serum-Con-2":"760.9816125","serum-Con-3":"982.4857891","serum-Con-4":"1200.467847","serum-Con-5":"1356.131505","serum-Con-6":"792.2722136","serum-KO-1":"1665.381525","serum-KO-2":"814.6822926","serum-KO-3":"1010.807574","serum-KO-4":"755.9267991","serum-KO-5":"846.6416757","serum-KO-6":"952.2807965","serum-KO-7":"846.6699022"},{"Metabolite":"8(9)-EET","serum-Con-1":"1455.636366","serum-Con-2":"1479.166909","serum-Con-3":"955.5842681","serum-Con-4":"4090.282956","serum-Con-5":"1423.454335","serum-Con-6":"1387.263729","serum-KO-1":"3041.652093","serum-KO-2":"859.559779","serum-KO-3":"1373.0913","serum-KO-4":"618.5003082","serum-KO-5":"494.7951829","serum-KO-6":"349.4196618","serum-KO-7":"690.7348279"},{"Metabolite":"Acetoacetic acid","serum-Con-1":"2458.556815","serum-Con-2":"2203.74705","serum-Con-3":"3983.799307","serum-Con-4":"1283.010741","serum-Con-5":"1528.981003","serum-Con-6":"1214.472032","serum-KO-1":"3349.922217","serum-KO-2":"6748.283313","serum-KO-3":"4141.276531","serum-KO-4":"1688.822854","serum-KO-5":"3201.367284","serum-KO-6":"1596.087584","serum-KO-7":"3053.613102"},{"Metabolite":"Aconitic acid","serum-Con-1":"1109521.2","serum-Con-2":"734655.1445","serum-Con-3":"779740.7685","serum-Con-4":"764333.3543","serum-Con-5":"589622.3658","serum-Con-6":"596270.8863","serum-KO-1":"781478.8524","serum-KO-2":"682127.7956","serum-KO-3":"763123.8693","serum-KO-4":"592012.9565","serum-KO-5":"493431.2435","serum-KO-6":"690262.6604","serum-KO-7":"564731.4974"},{"Metabolite":"Adenine","serum-Con-1":"136.2509901","serum-Con-2":"372.0610919","serum-Con-3":"208.5998115","serum-Con-4":"193.5065722","serum-Con-5":"327.7831319","serum-Con-6":"396.9743868","serum-KO-1":"295.4863232","serum-KO-2":"381.5826492","serum-KO-3":"351.7401839","serum-KO-4":"341.2616832","serum-KO-5":"267.1986275","serum-KO-6":"208.6169674","serum-KO-7":"369.9315396"},{"Metabolite":"Adipic acid","serum-Con-1":"2841.839824","serum-Con-2":"4141.179457","serum-Con-3":"4346.596172","serum-Con-4":"4525.632118","serum-Con-5":"5457.991885","serum-Con-6":"5805.848237","serum-KO-1":"3285.44702","serum-KO-2":"3830.191303","serum-KO-3":"3888.336486","serum-KO-4":"3889.240425","serum-KO-5":"3913.334837","serum-KO-6":"3581.660476","serum-KO-7":"4666.218272"},{"Metabolite":"ADP","serum-Con-1":"3099.420994","serum-Con-2":"1892.266894","serum-Con-3":"1262.802717","serum-Con-4":"3101.223446","serum-Con-5":"2102.637692","serum-Con-6":"1889.535777","serum-KO-1":"2579.904826","serum-KO-2":"1603.635246","serum-KO-3":"1708.639892","serum-KO-4":"1659.403258","serum-KO-5":"861.4422455","serum-KO-6":"1093.22525","serum-KO-7":"979.8201032"},{"Metabolite":"a-Ketoglutaric acid","serum-Con-1":"1656839.105","serum-Con-2":"1487520.941","serum-Con-3":"1329193.605","serum-Con-4":"878516.936","serum-Con-5":"1066257.167","serum-Con-6":"1285964.392","serum-KO-1":"1099337.231","serum-KO-2":"1497425.509","serum-KO-3":"1168961.843","serum-KO-4":"1291269.691","serum-KO-5":"1409278.597","serum-KO-6":"1720666.86","serum-KO-7":"973857.1781"},{"Metabolite":"Allantoin","serum-Con-1":"281079.7625","serum-Con-2":"284455.5521","serum-Con-3":"296997.968","serum-Con-4":"260457.7842","serum-Con-5":"326748.9775","serum-Con-6":"330909.804","serum-KO-1":"239313.5547","serum-KO-2":"271361.9647","serum-KO-3":"264666.329","serum-KO-4":"327767.2543","serum-KO-5":"244789.1165","serum-KO-6":"297177.9882","serum-KO-7":"267943.0627"},{"Metabolite":"AMP","serum-Con-1":"775319.9221","serum-Con-2":"51919.18669","serum-Con-3":"477254.413","serum-Con-4":"2059575.969","serum-Con-5":"475433.1291","serum-Con-6":"215255.3578","serum-KO-1":"228291.8154","serum-KO-2":"84389.79343","serum-KO-3":"437575.403","serum-KO-4":"216707.6047","serum-KO-5":"3356.932704","serum-KO-6":"90031.64296","serum-KO-7":"242894.3972"},{"Metabolite":"Anthranilic 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"Metabolites":[{"metabolite_name":"1,5-AG / 1-deoxyglucose"},{"metabolite_name":"11(12)-EET"},{"metabolite_name":"12-Oxo-ETE"},{"metabolite_name":"14(15)-EET"},{"metabolite_name":"15-Oxo-ETE"},{"metabolite_name":"20-Hydroxy-N-Arachidonoyl Taurine"},{"metabolite_name":"2-Aminoadipic acid"},{"metabolite_name":"2-Deoxyuridine"},{"metabolite_name":"2-Hydroxybutyric acid"},{"metabolite_name":"2-Hydroxyglutaric acid"},{"metabolite_name":"2-ketoisovaleric acid KIV"},{"metabolite_name":"3-Aminoisobutyric acid"},{"metabolite_name":"3-Hydroxybutyric acid"},{"metabolite_name":"5(6)-EET"},{"metabolite_name":"5-MTHF"},{"metabolite_name":"5-Oxo-ETE"},{"metabolite_name":"8(9)-EET"},{"metabolite_name":"Acetoacetic acid"},{"metabolite_name":"Aconitic acid"},{"metabolite_name":"Adenine"},{"metabolite_name":"Adipic acid"},{"metabolite_name":"ADP"},{"metabolite_name":"a-Ketoglutaric acid"},{"metabolite_name":"Allantoin"},{"metabolite_name":"AMP"},{"metabolite_name":"Anthranilic acid"},{"metabolite_name":"Arachidonic acid"},{"metabolite_name":"Arachindonoyl Phenylalanine"},{"metabolite_name":"Aspartic acid"},{"metabolite_name":"Atorvastatin"},{"metabolite_name":"ATP"},{"metabolite_name":"BHB-Leu"},{"metabolite_name":"BHB-Met"},{"metabolite_name":"BHB-Phe"},{"metabolite_name":"BHB-Val"},{"metabolite_name":"Bilirubin"},{"metabolite_name":"Butyric acid"},{"metabolite_name":"C12-Phe"},{"metabolite_name":"C15-Phe"},{"metabolite_name":"C16-Phe"},{"metabolite_name":"C18:1-Asn"},{"metabolite_name":"C18:1-Gln"},{"metabolite_name":"C18:1-Glu"},{"metabolite_name":"C18:1-Ile"},{"metabolite_name":"C18:1-Lys"},{"metabolite_name":"C18:1-Met"},{"metabolite_name":"C18:1-Pro"},{"metabolite_name":"C18:1-Ser"},{"metabolite_name":"C18:1-Trp"},{"metabolite_name":"C18:1-Tyr"},{"metabolite_name":"C18:2-Phe"},{"metabolite_name":"C18:3-Phe"},{"metabolite_name":"C20:4-Gly"},{"metabolite_name":"C20:4-Phe"},{"metabolite_name":"C20:4-Ser"},{"metabolite_name":"C20-Phe"},{"metabolite_name":"C22-Phe"},{"metabolite_name":"CDP-Choline"},{"metabolite_name":"Cholic acid"},{"metabolite_name":"Citraconic acid"},{"metabolite_name":"Citric acid/Isocitric acid"},{"metabolite_name":"Citrulline"},{"metabolite_name":"Citrulline-d7"},{"metabolite_name":"cyclic-AMP"},{"metabolite_name":"DDHAP/Glyceraldehyde-3-P"},{"metabolite_name":"Deoxycholic acid"},{"metabolite_name":"D-Gluconic acid"},{"metabolite_name":"DHA"},{"metabolite_name":"DiHOME"},{"metabolite_name":"Dihomo-Gammi-Linolenoyl Ethanolamide"},{"metabolite_name":"EPA"},{"metabolite_name":"Fumaric acid"},{"metabolite_name":"Glucose/Fructose/Galactose_waterloss"},{"metabolite_name":"Glutamic acid"},{"metabolite_name":"Glutathione Disulfide"},{"metabolite_name":"Glutathione_reduced"},{"metabolite_name":"Glyceric acid"},{"metabolite_name":"Glycerol-3-phosphate"},{"metabolite_name":"Glycochenodeoxycholic acid"},{"metabolite_name":"Glycocholic acid"},{"metabolite_name":"Glyoxylic Acid"},{"metabolite_name":"HETE"},{"metabolite_name":"Hippuric acid"},{"metabolite_name":"Homogentisic acid"},{"metabolite_name":"Hydroxyphenylpyruvic acid"},{"metabolite_name":"Hypoxanthine"},{"metabolite_name":"IMP"},{"metabolite_name":"Indole-3-carboxylic acid"},{"metabolite_name":"Indole-3-lactic acid"},{"metabolite_name":"Indole-3-propanoic acid"},{"metabolite_name":"Indoxyl-sulfate"},{"metabolite_name":"Inosine"},{"metabolite_name":"Inosine-15N4"},{"metabolite_name":"Keto-isocaproic acid KIC / Keto-methylvalerate KMV"},{"metabolite_name":"Kynurenic acid"},{"metabolite_name":"Kynurenine"},{"metabolite_name":"Lac-Arg"},{"metabolite_name":"Lac-Asn"},{"metabolite_name":"Lac-Asp"},{"metabolite_name":"Lac-Cys"},{"metabolite_name":"Lac-Gln"},{"metabolite_name":"Lac-Glu"},{"metabolite_name":"Lac-His"},{"metabolite_name":"Lac-Ile/leu"},{"metabolite_name":"Lac-Lys"},{"metabolite_name":"Lac-Met"},{"metabolite_name":"Lac-Phe"},{"metabolite_name":"Lac-Pro"},{"metabolite_name":"Lac-Ser"},{"metabolite_name":"Lac-Thr"},{"metabolite_name":"Lactic acid"},{"metabolite_name":"Lac-Tyr"},{"metabolite_name":"Lac-Val"},{"metabolite_name":"Linoleic acid"},{"metabolite_name":"Lisinopril"},{"metabolite_name":"Malic acid"},{"metabolite_name":"Malonic acid"},{"metabolite_name":"Mevalonic acid"},{"metabolite_name":"N-Acetyl-Histidine"},{"metabolite_name":"N-Acetyl-Isoleucine"},{"metabolite_name":"N-Acetyl-L-Alanine"},{"metabolite_name":"N-Acetyl-L-Aspartic acid"},{"metabolite_name":"N-Acetyl-L-Glutamic acid"},{"metabolite_name":"N-Acetyl-L-Glutamine"},{"metabolite_name":"N-Acetyl-L-Glycine"},{"metabolite_name":"N-Acetyl-L-Methionine"},{"metabolite_name":"N-Acetyl-Valine"},{"metabolite_name":"N-Actyl-D-Glycosamine"},{"metabolite_name":"N-Arachidonoyl Dopamine"},{"metabolite_name":"N-Arachidonoyl Taurine"},{"metabolite_name":"N-Docosanoyl Taurine"},{"metabolite_name":"N-Lignoceroyl Taurine"},{"metabolite_name":"N-Nervonoyl Taurine"},{"metabolite_name":"N-Oleoyl Dopamine"},{"metabolite_name":"N-Oleoyl Taurine"},{"metabolite_name":"N-Palmitoyl Taurine"},{"metabolite_name":"Oleamide"},{"metabolite_name":"Oleoyl Glycine"},{"metabolite_name":"Oleoyl Leucine"},{"metabolite_name":"Oleoyl Phenylalanine"},{"metabolite_name":"Oleoyl Serine"},{"metabolite_name":"Orotic acid"},{"metabolite_name":"Oxalic acid"},{"metabolite_name":"Oxaloacetic acid"},{"metabolite_name":"Oxypurinol"},{"metabolite_name":"Palmitic acid"},{"metabolite_name":"Pantothenic acid"},{"metabolite_name":"Phe-d8"},{"metabolite_name":"Phosphocreatine"},{"metabolite_name":"Pravastatin"},{"metabolite_name":"Pseudouridine"},{"metabolite_name":"Pyroglutamic acid"},{"metabolite_name":"Pyruvic acid"},{"metabolite_name":"Quinolinic acid"},{"metabolite_name":"Saccharopine"},{"metabolite_name":"S-Adenosyl-L-homocysteine"},{"metabolite_name":"Salicylic acid"},{"metabolite_name":"Simvastatin"},{"metabolite_name":"Stearic acid"},{"metabolite_name":"Succinic acid/Methylmalonic acid"},{"metabolite_name":"T3"},{"metabolite_name":"T4"},{"metabolite_name":"Taurine"},{"metabolite_name":"Taurocholic acid"},{"metabolite_name":"Taurodeoxycholic acid / Taurochenodeoxycholic acid"},{"metabolite_name":"Thymidine"},{"metabolite_name":"Thymine-d4"},{"metabolite_name":"UDP-GlcNAc"},{"metabolite_name":"UDP-glucose / -galactose"},{"metabolite_name":"Uracil"},{"metabolite_name":"Uric acid"},{"metabolite_name":"Uridine"},{"metabolite_name":"Warfarin"},{"metabolite_name":"Xanthine"},{"metabolite_name":"Xanthosine"},{"metabolite_name":"Xanthurenic acid"}]
}

}