{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST003097","ANALYSIS_ID":"AN005068","VERSION":"1","CREATED_ON":"February 18, 2024, 2:16 am"},

"PROJECT":{"PROJECT_TITLE":"Probiotic intervention of FMT mice","PROJECT_SUMMARY":"L. plantarum intervention of gestational fecal microbiome transplant germ-free mice","INSTITUTE":"Beijing Sanyuan Foods Co. Ltd","LAST_NAME":"Bin","FIRST_NAME":"Liu","ADDRESS":"8th yingchang street, yinghai distric","EMAIL":"liubin@sanyuan.com.cn","PHONE":"01056306594"},

"STUDY":{"STUDY_TITLE":"probiotic on gestational health of FMT GF mice","STUDY_SUMMARY":"probiotic L.plantarum intervention gestational on FMT GF mice","INSTITUTE":"Beijing Sanyuan Foods Co. Ltd","LAST_NAME":"Liu","FIRST_NAME":"Bin","ADDRESS":"8th yingchang street, yinghai distric","EMAIL":"liubin@sanyuan.com.cn","PHONE":"01056306594"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090","GENDER":"Female"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"908MN",
"Factors":{"Sample source":"cecum content","Factor":"control"},
"Additional sample data":{"RAW_FILE_NAME":"Wangyaru-P220801102.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"188MN",
"Factors":{"Sample source":"cecum content","Factor":"control"},
"Additional sample data":{"RAW_FILE_NAME":"Wangyaru-P220801103.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"909MN",
"Factors":{"Sample source":"cecum content","Factor":"control"},
"Additional sample data":{"RAW_FILE_NAME":"Wangyaru-P220801104.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"185MN",
"Factors":{"Sample source":"cecum content","Factor":"control"},
"Additional sample data":{"RAW_FILE_NAME":"Wangyaru-P220801105.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"180MN",
"Factors":{"Sample source":"cecum content","Factor":"intervention"},
"Additional sample data":{"RAW_FILE_NAME":"Wangyaru-P220801106.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"907MN",
"Factors":{"Sample source":"cecum content","Factor":"intervention"},
"Additional sample data":{"RAW_FILE_NAME":"Wangyaru-P220801107.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"81MN",
"Factors":{"Sample source":"cecum content","Factor":"intervention"},
"Additional sample data":{"RAW_FILE_NAME":"Wangyaru-P220801108.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"107MN",
"Factors":{"Sample source":"cecum content","Factor":"intervention"},
"Additional sample data":{"RAW_FILE_NAME":"Wangyaru-P220801109.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"120MN",
"Factors":{"Sample source":"cecum content","Factor":"intervention"},
"Additional sample data":{"RAW_FILE_NAME":"Wangyaru-P220801110.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"122MN",
"Factors":{"Sample source":"cecum content","Factor":"intervention"},
"Additional sample data":{"RAW_FILE_NAME":"Wangyaru-P220801111.mzML"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"cecum content sample was collected and stored at -80°C environment","SAMPLE_TYPE":"Cecum","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"mice were randomly assigned into two experimental groups, named control and intervention groups, receiving standard chow feeding, and standard chow + L. plantarum"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"sample was extracted in 400 μL of methanol, and were centrifuged at 4 °C for 10 min at 12000 rpm after vortexing for 10 min and the supernatant was resolved in water and filtered and then transferred into the vial","PROCESSING_STORAGE_CONDITIONS":"4℃","EXTRACT_STORAGE":"-80℃"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"LC","INSTRUMENT_NAME":"Shimmadzu LC-30","COLUMN_NAME":"Waters ACQUITY UPLC BEH C18 (100 x 2.1mm,1.7um)","SOLVENT_A":"formic acid in water","SOLVENT_B":"acetonitrile","FLOW_GRADIENT":"30% B; 9~14 min, 30~36% B; 14~18 min,36~38% B; 18~24 min, 38~50% B; 24~32 min, 50~75% B; 32~33 min, 75~90% B; 33~35.5 min, 90~30% B","FLOW_RATE":"0.25 mL/min","COLUMN_TEMPERATURE":"40"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"ABI Sciex 6500+","INSTRUMENT_TYPE":"Single quadrupole","MS_TYPE":"ESI","ION_MODE":"NEGATIVE","MS_COMMENTS":"Single ion monitoring (SIM) mode was used with the electron energy of 70 eV.MS Convert software (Proteowizard, v3.0.8789) was applied to convert “.raw” format raw data to “.mzML” format, which would be used for downstream analysis."},

"MS_METABOLITE_DATA":{
"Units":"μg/g",

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"Metabolites":[{"Metabolite":"alloLCA","retention index":"31.1","quantified m/z":"375.302","PubChem ID":"94228","KEGG ID":"0"},{"Metabolite":"LCA","retention index":"32.9","quantified m/z":"375.3","PubChem ID":"9903","KEGG ID":"C03990"},{"Metabolite":"isoLCA","retention index":"31.4","quantified m/z":"375.288","PubChem ID":"164853?","KEGG ID":"C17658"},{"Metabolite":"NorDCA","retention index":"25.7","quantified m/z":"377.301","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"S7ketoLCA","retention index":"30","quantified m/z":"389.3","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"S12ketoLCA","retention index":"25.7","quantified m/z":"389.314","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"betaUDCA","retention index":"20.7","quantified m/z":"391.311","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"DCA","retention index":"28.5","quantified m/z":"391.3","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"CDCA","retention index":"27.9","quantified m/z":"391.301","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"HDCA","retention index":"23.2","quantified m/z":"391.303","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"NorCA","retention index":"16","quantified m/z":"393.211","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"S712diketoLCA","retention index":"11.7","quantified m/z":"403.25","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"S67diketoLCA","retention index":"25.3","quantified m/z":"403.3","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"alphaMCA","retention index":"15.6","quantified m/z":"407.3","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"UCA","retention index":"10.9","quantified m/z":"407.301","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"betaMCA","retention index":"16.6","quantified m/z":"407.302","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"CA","retention index":"22.1","quantified m/z":"407.303","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"ACA","retention index":"21.6","quantified m/z":"407.304","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"GDCA","retention index":"24.1","quantified m/z":"448.279","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"LCA3S","retention index":"31.7","quantified m/z":"455.196","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"GCA","retention index":"15.4","quantified m/z":"464.281","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"TLCA","retention index":"29.9","quantified m/z":"482.223","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"THDCATUDCA","retention index":"12.9","quantified m/z":"498.411","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"TDCA","retention index":"23.3","quantified m/z":"498.35","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"TCDCA","retention index":"21.7","quantified m/z":"498.357","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"TCA","retention index":"14","quantified m/z":"514.332","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"TalphaMCA","retention index":"5.67","quantified m/z":"514.311","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"THCA","retention index":"9.09","quantified m/z":"514.3","PubChem ID":"0","KEGG ID":"0"},{"Metabolite":"TbetaMCA","retention index":"6.02","quantified m/z":"514.287","PubChem ID":"0","KEGG ID":"0"}]
}

}