{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST003118","ANALYSIS_ID":"AN005112","VERSION":"1","CREATED_ON":"March 8, 2024, 9:58 am"},

"PROJECT":{"PROJECT_TITLE":"Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes","PROJECT_SUMMARY":"The most prevalent genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia is a (GGGGCC)n nucleotide repeat expansion (NRE) occurring in the first intron of the C9orf72 gene (C9). Brain glucose hypometabolism is consistently observed in C9-NRE carriers, even at pre-symptomatic stages, although its potential role in disease pathogenesis is unknown. Here, we identified alterations in glucose metabolic pathways and ATP levels in the brains of asymptomatic C9-BAC mice. We found that, through activation of the GCN2 kinase, glucose hypometabolism drives the production of dipeptide repeat proteins (DPRs), impairs the survival of C9 patient-derived neurons, and triggers motor dysfunction in C9-BAC mice. We also found that one of the arginine-rich DPRs (PR) can directly contribute to glucose metabolism and metabolic stress. These findings provide a potential mechanistic link between energy imbalances and C9-ALS/FTD pathogenesis and suggest","INSTITUTE":"Thomas Jefferson University","LAST_NAME":"Trotti","FIRST_NAME":"Davide","ADDRESS":"900 Walnut Street, Philadelphia PA 19107","EMAIL":"davide.trotti@jefferson.edu","PHONE":"215-955-8416"},

"STUDY":{"STUDY_TITLE":"Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes - Study 2","STUDY_SUMMARY":"The most prevalent genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia is a (GGGGCC)n nucleotide repeat expansion (NRE) occurring in the first intron of the C9orf72 gene (C9). Brain glucose hypometabolism is consistently observed in C9-NRE carriers, even at pre-symptomatic stages, although its potential role in disease pathogenesis is unknown. Here, we identified alterations in glucose metabolic pathways and ATP levels in the brains of asymptomatic C9-BAC mice. We found that, through activation of the GCN2 kinase, glucose hypometabolism drives the production of dipeptide repeat proteins (DPRs), impairs the survival of C9 patient-derived neurons, and triggers motor dysfunction in C9-BAC mice. We also found that one of the arginine-rich DPRs (PR) can directly contribute to glucose metabolism and metabolic stress. These findings provide a potential mechanistic link between energy imbalances and C9-ALS/FTD pathogenesis and suggest a feedforward loop model that opens several opportunities for therapeutic intervention.","INSTITUTE":"Thomas Jefferson University","LAST_NAME":"Trotti","FIRST_NAME":"Davide","ADDRESS":"900 Walnut Street, Philadelphia, PA 19107, USA","EMAIL":"davide.trotti@jefferson.edu","PHONE":"215-955-8416"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"2DG_1",
"Factors":{"Sample source":"Brain","Treatment":"2DG"},
"Additional sample data":{"Genotype":"WT","RAW_FILE_NAME(Raw File Name)":"2DG_1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"2DG_2",
"Factors":{"Sample source":"Brain","Treatment":"2DG"},
"Additional sample data":{"Genotype":"WT","RAW_FILE_NAME(Raw File Name)":"2DG_2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"2DG_3",
"Factors":{"Sample source":"Brain","Treatment":"2DG"},
"Additional sample data":{"Genotype":"WT","RAW_FILE_NAME(Raw File Name)":"2DG_3.raw"}
},
{
"Subject ID":"-",
"Sample ID":"2DG_4",
"Factors":{"Sample source":"Brain","Treatment":"2DG"},
"Additional sample data":{"Genotype":"WT","RAW_FILE_NAME(Raw File Name)":"2DG_4.raw"}
},
{
"Subject ID":"-",
"Sample ID":"2DG_5",
"Factors":{"Sample source":"Brain","Treatment":"2DG"},
"Additional sample data":{"Genotype":"WT","RAW_FILE_NAME(Raw File Name)":"2DG_5.raw"}
},
{
"Subject ID":"-",
"Sample ID":"Saline_1",
"Factors":{"Sample source":"Brain","Treatment":"Saline"},
"Additional sample data":{"Genotype":"WT","RAW_FILE_NAME(Raw File Name)":"Saline_1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"Saline_2",
"Factors":{"Sample source":"Brain","Treatment":"Saline"},
"Additional sample data":{"Genotype":"WT","RAW_FILE_NAME(Raw File Name)":"Saline_2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"Saline_3",
"Factors":{"Sample source":"Brain","Treatment":"Saline"},
"Additional sample data":{"Genotype":"WT","RAW_FILE_NAME(Raw File Name)":"Saline_3.raw"}
},
{
"Subject ID":"-",
"Sample ID":"Saline_4",
"Factors":{"Sample source":"Brain","Treatment":"Saline"},
"Additional sample data":{"Genotype":"WT","RAW_FILE_NAME(Raw File Name)":"Saline_4.raw"}
},
{
"Subject ID":"-",
"Sample ID":"Saline_5",
"Factors":{"Sample source":"Brain","Treatment":"Saline"},
"Additional sample data":{"Genotype":"WT","RAW_FILE_NAME(Raw File Name)":"Saline_5.raw"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Animals were euthanized by CO2 inhalation 16 hours following the final injection and transcardially perfused with ice-cold PBS. Whole brains and spinal cords were then excised, flash frozen in liquid N2, and stored at –80°C for biochemical analysis.","SAMPLE_TYPE":"Brain"},

"TREATMENT":{"TREATMENT_SUMMARY":"Mice were administered i.p. injections of saline (vehicle) or 4 g/kg 2DG (Cayman Chemical) twice weekly for six weeks."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Metabolites from equal amounts of frontal cortex tissue were rapidly extracted in 80% ice-cold methanol. Extracted samples were vortexed twice, cleared by centrifugation at 14,000 x g for 20 minutes at 4°C, and stored at -80°C."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Thermo Vanquish","COLUMN_NAME":"Merck SeQuant ZIC-pHILIC (150 x 2.1mm,5um)","SOLVENT_A":"100% acetonitrile","SOLVENT_B":"100% water; 0.1% ammonium hydroxide; 20 mM ammonium acetate","FLOW_GRADIENT":"85% to 30% A in 20 min followed by a wash with 30% A and re-equilibration at 85% A","FLOW_RATE":"150 μL/min","COLUMN_TEMPERATURE":"30"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"UNSPECIFIED","MS_COMMENTS":"1. A Sequant ZIC-pHILIC column (2.1 mm i.d. × 150 mm, particle size of 5 µm, Millipore Sigma) was used for separation of metabolites. A 2.1 × 20 mm guard column with the same packing material was used for protection of the analytical column. Flow rate was set at 150 μL/min. Buffers consisted of 100% acetonitrile for mobile phase A, and 100% acetonitrile for mobile phase B. The chromatographic gradient ran from 85% to 30% A in 20 min followed by a wash with 30% A and re-equilibration at 85% A. Column temperature was 30 C."},

"MS_METABOLITE_DATA":{
"Units":"peak intensity",

"Data":[{"Metabolite":"1-Methyladenosine","2DG_1":"18071.72","2DG_2":"29601.59","2DG_3":"20265.86","2DG_4":"20179.12","2DG_5":"25176.21","Saline_1":"20435.63","Saline_2":"15805.12","Saline_3":"26556.56","Saline_4":"18352.03","Saline_5":"27356.23"},{"Metabolite":"1-Methylnicotinamide","2DG_1":"0","2DG_2":"0","2DG_3":"0","2DG_4":"0","2DG_5":"0","Saline_1":"0","Saline_2":"0","Saline_3":"0","Saline_4":"0","Saline_5":"0"},{"Metabolite":"2-Hydroxycaproic acid","2DG_1":"252036.5","2DG_2":"336503.3","2DG_3":"150708.8","2DG_4":"182674.3","2DG_5":"208359","Saline_1":"342401.1","Saline_2":"268423","Saline_3":"231255.7","Saline_4":"224091.6","Saline_5":"303093.6"},{"Metabolite":"2-Hydroxyvaleric acid","2DG_1":"2022956","2DG_2":"1894132","2DG_3":"1561093","2DG_4":"1544935","2DG_5":"3276415","Saline_1":"3049344","Saline_2":"2903548","Saline_3":"3769964","Saline_4":"2819770","Saline_5":"2507179"},{"Metabolite":"3-Hydroxymethylglutaric acid","2DG_1":"13556870","2DG_2":"15763370","2DG_3":"14454340","2DG_4":"13115170","2DG_5":"15221390","Saline_1":"17466840","Saline_2":"15363070","Saline_3":"17481170","Saline_4":"16075470","Saline_5":"15261380"},{"Metabolite":"3-Indolepropionic acid","2DG_1":"5807.522","2DG_2":"17724.86","2DG_3":"7704.766","2DG_4":"8368.431","2DG_5":"0","Saline_1":"5648.745","Saline_2":"8815.446","Saline_3":"5694.466","Saline_4":"6909.297","Saline_5":"10304.33"},{"Metabolite":"3-Methylhistidine","2DG_1":"12789620","2DG_2":"9603358","2DG_3":"9999853","2DG_4":"8921684","2DG_5":"8885028","Saline_1":"16566540","Saline_2":"12191780","Saline_3":"16826830","Saline_4":"10785260","Saline_5":"13711690"},{"Metabolite":"3-Phosphoglyceric acid","2DG_1":"620132.8","2DG_2":"116324.7","2DG_3":"422951.6","2DG_4":"219568.2","2DG_5":"458680.8","Saline_1":"344162.8","Saline_2":"206785.6","Saline_3":"163721.6","Saline_4":"172609.3","Saline_5":"176084.9"},{"Metabolite":"4-Acetamidobutanoic acid","2DG_1":"46045.81","2DG_2":"43092.77","2DG_3":"32575.34","2DG_4":"39037.89","2DG_5":"46626.91","Saline_1":"39254.08","Saline_2":"29085.13","Saline_3":"46967.66","Saline_4":"35428.63","Saline_5":"32975.09"},{"Metabolite":"4-Guanidinobutanoic acid","2DG_1":"25369180","2DG_2":"35409220","2DG_3":"30266640","2DG_4":"28637260","2DG_5":"25523500","Saline_1":"34845760","Saline_2":"32768170","Saline_3":"19450590","Saline_4":"33898070","Saline_5":"34336890"},{"Metabolite":"4-Hydroxyproline","2DG_1":"686297.9","2DG_2":"785089.4","2DG_3":"760941.4","2DG_4":"370256.6","2DG_5":"1042048","Saline_1":"582524.2","Saline_2":"590611.4","Saline_3":"754577.1","Saline_4":"640397.9","Saline_5":"684553.6"},{"Metabolite":"4-Pyridoxic acid","2DG_1":"40150.09","2DG_2":"34054.97","2DG_3":"20591.15","2DG_4":"20710.53","2DG_5":"33073.89","Saline_1":"27534.29","Saline_2":"32278.24","Saline_3":"56385.55","Saline_4":"24461.68","Saline_5":"32769.61"},{"Metabolite":"4-Trimethylammoniobutanoic acid","2DG_1":"44740840","2DG_2":"16544860","2DG_3":"24587280","2DG_4":"20609160","2DG_5":"39557420","Saline_1":"22627920","Saline_2":"19744900","Saline_3":"46942940","Saline_4":"15877420","Saline_5":"18876510"},{"Metabolite":"5-Thymidylic acid","2DG_1":"21217.02","2DG_2":"0","2DG_3":"0","2DG_4":"0","2DG_5":"0","Saline_1":"0","Saline_2":"0","Saline_3":"20952.56","Saline_4":"13723.12","Saline_5":"0"},{"Metabolite":"6-Phosphogluconic acid","2DG_1":"131992.5","2DG_2":"131688.5","2DG_3":"175743.7","2DG_4":"165336.5","2DG_5":"145896","Saline_1":"189156.5","Saline_2":"157567.1","Saline_3":"107400.6","Saline_4":"109946","Saline_5":"137909.7"},{"Metabolite":"6-Phosphonoglucono-D-lactone","2DG_1":"0","2DG_2":"0","2DG_3":"0","2DG_4":"0","2DG_5":"0","Saline_1":"0","Saline_2":"0","Saline_3":"0","Saline_4":"0","Saline_5":"0"},{"Metabolite":"Acetyl-CoA","2DG_1":"48207.97","2DG_2":"48103.22","2DG_3":"43729.89","2DG_4":"45862.57","2DG_5":"0","Saline_1":"49953.14","Saline_2":"45896.35","Saline_3":"70377.66","Saline_4":"42575.23","Saline_5":"48469.41"},{"Metabolite":"Acetylcholine","2DG_1":"30827770","2DG_2":"10730870","2DG_3":"8887630","2DG_4":"9589687","2DG_5":"14276310","Saline_1":"23476840","Saline_2":"13938970","Saline_3":"31426450","Saline_4":"11610480","Saline_5":"11394450"},{"Metabolite":"Acetylcysteine","2DG_1":"17751.24","2DG_2":"9495.161","2DG_3":"11938.73","2DG_4":"8304.947","2DG_5":"15173.49","Saline_1":"7589.546","Saline_2":"7026.146","Saline_3":"14813.04","Saline_4":"9404.046","Saline_5":"9958.996"},{"Metabolite":"Adenine","2DG_1":"57532370","2DG_2":"78896990","2DG_3":"48441640","2DG_4":"51670050","2DG_5":"66133490","Saline_1":"72162600","Saline_2":"72289640","Saline_3":"80030930","Saline_4":"73680770","Saline_5":"77598780"},{"Metabolite":"Adenosine","2DG_1":"510359200","2DG_2":"569644700","2DG_3":"378821000","2DG_4":"362377200","2DG_5":"600005100","Saline_1":"420762400","Saline_2":"415815200","Saline_3":"770467500","Saline_4":"471018300","Saline_5":"476921600"},{"Metabolite":"Adenosine monophosphate","2DG_1":"293154700","2DG_2":"166545300","2DG_3":"251022600","2DG_4":"234724100","2DG_5":"243260000","Saline_1":"339932600","Saline_2":"295190100","Saline_3":"286926300","Saline_4":"238276700","Saline_5":"231522900"},{"Metabolite":"Adenosine triphosphate","2DG_1":"55298.82","2DG_2":"42226.78","2DG_3":"58668.57","2DG_4":"44131.63","2DG_5":"64070.81","Saline_1":"39622.98","Saline_2":"45921.45","Saline_3":"41131.29","Saline_4":"31888.87","Saline_5":"25967.82"},{"Metabolite":"ADP","2DG_1":"1741428","2DG_2":"541010.4","2DG_3":"1250016","2DG_4":"1025581","2DG_5":"1670941","Saline_1":"957723.4","Saline_2":"1335735","Saline_3":"886248.4","Saline_4":"725768.8","Saline_5":"841852.4"},{"Metabolite":"ADP-glucose","2DG_1":"48651.97","2DG_2":"57930.48","2DG_3":"50349.39","2DG_4":"52831.91","2DG_5":"47750.59","Saline_1":"89235.5","Saline_2":"70518.15","Saline_3":"73597.64","Saline_4":"62812.55","Saline_5":"62514.85"},{"Metabolite":"AICAR","2DG_1":"265721.9","2DG_2":"268141.1","2DG_3":"252398.9","2DG_4":"227734.9","2DG_5":"294959.6","Saline_1":"156866.6","Saline_2":"163426.2","Saline_3":"140513","Saline_4":"125417.4","Saline_5":"114242.2"},{"Metabolite":"Allantoin","2DG_1":"564283.9","2DG_2":"468667.9","2DG_3":"364734.9","2DG_4":"295323.6","2DG_5":"543052.2","Saline_1":"590014.9","Saline_2":"537383.6","Saline_3":"767742.6","Saline_4":"486362.4","Saline_5":"514008.1"},{"Metabolite":"Aminoadipic acid","2DG_1":"1927212","2DG_2":"2144710","2DG_3":"2343838","2DG_4":"1189015","2DG_5":"2065791","Saline_1":"2434013","Saline_2":"2130197","Saline_3":"1831133","Saline_4":"1602844","Saline_5":"1604167"},{"Metabolite":"Anserine","2DG_1":"898437.7","2DG_2":"719937.8","2DG_3":"911614.5","2DG_4":"990996.8","2DG_5":"744031.3","Saline_1":"1312312","Saline_2":"801825.2","Saline_3":"1242324","Saline_4":"1102723","Saline_5":"1168963"},{"Metabolite":"Argininosuccinic acid","2DG_1":"848237.1","2DG_2":"1336935","2DG_3":"969789.8","2DG_4":"859067.5","2DG_5":"984727.5","Saline_1":"894632","Saline_2":"808320.9","Saline_3":"939220.3","Saline_4":"1006648","Saline_5":"870770.3"},{"Metabolite":"Asymmetric dimethylarginine","2DG_1":"4019863","2DG_2":"3466609","2DG_3":"2902151","2DG_4":"4300072","2DG_5":"3969144","Saline_1":"4895214","Saline_2":"4107970","Saline_3":"4765254","Saline_4":"3499095","Saline_5":"4228862"},{"Metabolite":"Betaine","2DG_1":"145072900","2DG_2":"190533200","2DG_3":"179342200","2DG_4":"130802300","2DG_5":"150686100","Saline_1":"172759600","Saline_2":"169059300","Saline_3":"136329800","Saline_4":"160977300","Saline_5":"178806700"},{"Metabolite":"Butyrylcarnitine","2DG_1":"26648530","2DG_2":"18788020","2DG_3":"19506820","2DG_4":"35396130","2DG_5":"21041330","Saline_1":"28525710","Saline_2":"33811250","Saline_3":"19440730","Saline_4":"22058050","Saline_5":"23480590"},{"Metabolite":"Caprylic acid","2DG_1":"1332729","2DG_2":"1554668","2DG_3":"1189772","2DG_4":"1227729","2DG_5":"1232416","Saline_1":"1514423","Saline_2":"1280417","Saline_3":"1086439","Saline_4":"1387895","Saline_5":"1305085"},{"Metabolite":"Carnosine","2DG_1":"140248600","2DG_2":"145589600","2DG_3":"127975500","2DG_4":"130758100","2DG_5":"159177600","Saline_1":"155700300","Saline_2":"136089700","Saline_3":"233230400","Saline_4":"133327400","Saline_5":"147243900"},{"Metabolite":"CDP","2DG_1":"17262.23","2DG_2":"0","2DG_3":"0","2DG_4":"0","2DG_5":"17467.67","Saline_1":"0","Saline_2":"0","Saline_3":"0","Saline_4":"0","Saline_5":"0"},{"Metabolite":"CDP-Ethanolamine","2DG_1":"2994532","2DG_2":"1807672","2DG_3":"1777802","2DG_4":"1649207","2DG_5":"2560438","Saline_1":"2250865","Saline_2":"1906025","Saline_3":"3020473","Saline_4":"1729336","Saline_5":"1761456"},{"Metabolite":"Choline","2DG_1":"28128390","2DG_2":"59231190","2DG_3":"44411680","2DG_4":"35941120","2DG_5":"38339280","Saline_1":"45109910","Saline_2":"32944530","Saline_3":"42595220","Saline_4":"53113650","Saline_5":"42003240"},{"Metabolite":"cis-Aconitic acid","2DG_1":"2213871","2DG_2":"5405462","2DG_3":"3586681","2DG_4":"4108968","2DG_5":"2541130","Saline_1":"4870676","Saline_2":"3306326","Saline_3":"5602864","Saline_4":"3980751","Saline_5":"3712438"},{"Metabolite":"Citicoline","2DG_1":"9066455","2DG_2":"7897352","2DG_3":"6801960","2DG_4":"7131539","2DG_5":"8017035","Saline_1":"9256754","Saline_2":"8831307","Saline_3":"9786534","Saline_4":"6930339","Saline_5":"9249086"},{"Metabolite":"Citric acid","2DG_1":"10026030","2DG_2":"21837030","2DG_3":"21909960","2DG_4":"19151100","2DG_5":"12632860","Saline_1":"20389100","Saline_2":"18771260","Saline_3":"28591090","Saline_4":"17225750","Saline_5":"15299200"},{"Metabolite":"Citrulline","2DG_1":"7329839","2DG_2":"16771450","2DG_3":"15785440","2DG_4":"17048920","2DG_5":"8420502","Saline_1":"17723310","Saline_2":"18837290","Saline_3":"11471360","Saline_4":"19635650","Saline_5":"16579700"},{"Metabolite":"Coenzyme A","2DG_1":"0","2DG_2":"0","2DG_3":"0","2DG_4":"0","2DG_5":"0","Saline_1":"0","Saline_2":"0","Saline_3":"95911.18","Saline_4":"93145.95","Saline_5":"0"},{"Metabolite":"Creatine","2DG_1":"1833928000","2DG_2":"2151483000","2DG_3":"2019593000","2DG_4":"2012936000","2DG_5":"1746102000","Saline_1":"2323133000","Saline_2":"2112693000","Saline_3":"1835404000","Saline_4":"1965508000","Saline_5":"2035944000"},{"Metabolite":"Creatinine","2DG_1":"50762710","2DG_2":"61545550","2DG_3":"50134150","2DG_4":"60339260","2DG_5":"52575520","Saline_1":"66797980","Saline_2":"53017040","Saline_3":"48757900","Saline_4":"49998500","Saline_5":"51273970"},{"Metabolite":"Cyclic AMP","2DG_1":"277023","2DG_2":"114447","2DG_3":"179289.9","2DG_4":"131296.6","2DG_5":"198919.6","Saline_1":"224148.8","Saline_2":"161820.3","Saline_3":"243043.7","Saline_4":"162981.6","Saline_5":"134656.1"},{"Metabolite":"Cytidine","2DG_1":"8217764","2DG_2":"2048669","2DG_3":"4917061","2DG_4":"4313228","2DG_5":"8570116","Saline_1":"5265363","Saline_2":"2637897","Saline_3":"9639603","Saline_4":"1959524","Saline_5":"2700455"},{"Metabolite":"Cytidine monophosphate","2DG_1":"3923832","2DG_2":"3075407","2DG_3":"2989602","2DG_4":"2621002","2DG_5":"3535552","Saline_1":"3987320","Saline_2":"2648752","Saline_3":"5139000","Saline_4":"2803018","Saline_5":"2570240"},{"Metabolite":"Cytidine 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"Metabolites":[{"Metabolite":"1-Methyladenosine","HMDB":"HMDB0003331"},{"Metabolite":"1-Methylnicotinamide","HMDB":"HMDB0000699"},{"Metabolite":"2-Hydroxycaproic acid","HMDB":"HMDB0001624"},{"Metabolite":"2-Hydroxyvaleric acid","HMDB":"HMDB0001863"},{"Metabolite":"3-Hydroxymethylglutaric acid","HMDB":"HMDB0000355"},{"Metabolite":"3-Indolepropionic acid","HMDB":"HMDB0002302"},{"Metabolite":"3-Methylhistidine","HMDB":"HMDB0000479"},{"Metabolite":"3-Phosphoglyceric acid","HMDB":"HMDB0000807"},{"Metabolite":"4-Acetamidobutanoic acid","HMDB":"HMDB0003681"},{"Metabolite":"4-Guanidinobutanoic acid","HMDB":"HMDB0003464"},{"Metabolite":"4-Hydroxyproline","HMDB":"HMDB0000725"},{"Metabolite":"4-Pyridoxic acid","HMDB":"HMDB0000017"},{"Metabolite":"4-Trimethylammoniobutanoic acid","HMDB":"HMDB0001161"},{"Metabolite":"5-Thymidylic acid","HMDB":"HMDB0001227"},{"Metabolite":"6-Phosphogluconic 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}

}