#METABOLOMICS WORKBENCH nsouthwell_20240306_164620 DATATRACK_ID:4691 STUDY_ID:ST003128 ANALYSIS_ID:AN005130 VERSION 1 CREATED_ON 03-22-2024 #PROJECT PR:PROJECT_TITLE High fat diet ameliorates mitochondrial cardiomyopathy in CHCHD10 mutant mice PR:PROJECT_SUMMARY Mutations in CHCHD10, a mitochondrial protein with undefined functions, are PR:PROJECT_SUMMARY associated with autosomal dominant mitochondrial diseases. Chchd10 knock-in mice PR:PROJECT_SUMMARY harboring a heterozygous S55L mutation (equivalent to human pathogenic S59L) PR:PROJECT_SUMMARY develop a fatal mitochondrial cardiomyopathy caused by CHCHD10 aggregation and PR:PROJECT_SUMMARY proteotoxic mitochondrial integrated stress response (mtISR). In mutant hearts, PR:PROJECT_SUMMARY mtISR is accompanied by a metabolic rewiring characterized by increased reliance PR:PROJECT_SUMMARY on glycolysis rather than fatty acid oxidation. To counteract this metabolic PR:PROJECT_SUMMARY rewiring, heterozygous S55L mice were subjected to chronic high fat diet (HFD) PR:PROJECT_SUMMARY to decrease insulin sensitivity and glucose uptake and enhance fatty acid PR:PROJECT_SUMMARY utilization in the heart. HFD ameliorated the ventricular dysfunction of mutant PR:PROJECT_SUMMARY hearts and significantly extended the survival of mutant female mice affected by PR:PROJECT_SUMMARY severe pregnancy-induced cardiomyopathy. Gene expression profiles confirmed that PR:PROJECT_SUMMARY HFD increased fatty acid utilization and ameliorated cardiomyopathy markers. PR:PROJECT_SUMMARY Importantly, HFD also decreased accumulation of aggregated CHCHD10 in the S55L PR:PROJECT_SUMMARY heart, suggesting activation of quality control mechanisms. Overall, our PR:PROJECT_SUMMARY findings indicate that metabolic therapy can be effective in mitochondrial PR:PROJECT_SUMMARY cardiomyopathies associated with proteotoxic stress. PR:INSTITUTE Weill Cornell Medicine PR:LAST_NAME Southwell PR:FIRST_NAME Nneka PR:ADDRESS 407 E 61st St PR:EMAIL nns4001@med.cornell.edu PR:PHONE 646-962-8172 PR:DOI http://dx.doi.org/10.21228/M8FD9G #STUDY ST:STUDY_TITLE Effect of high fat diet on serum fatty acids, lipidome and metabolome in CHCHD10 ST:STUDY_TITLE mutant mice ST:STUDY_SUMMARY Mutations in CHCHD10, a mitochondrial protein with undefined functions, are ST:STUDY_SUMMARY associated with autosomal dominant mitochondrial diseases. Chchd10 knock-in mice ST:STUDY_SUMMARY harboring a heterozygous S55L mutation (equivalent to human pathogenic S59L) ST:STUDY_SUMMARY develop a fatal mitochondrial cardiomyopathy caused by CHCHD10 aggregation and ST:STUDY_SUMMARY proteotoxic mitochondrial integrated stress response (mtISR). In mutant hearts, ST:STUDY_SUMMARY mtISR is accompanied by a metabolic rewiring characterized by increased reliance ST:STUDY_SUMMARY on glycolysis rather than fatty acid oxidation. To counteract this metabolic ST:STUDY_SUMMARY rewiring, heterozygous S55L mice were subjected to chronic high fat diet (HFD) ST:STUDY_SUMMARY to decrease insulin sensitivity and glucose uptake and enhance fatty acid ST:STUDY_SUMMARY utilization in the heart. HFD ameliorated the ventricular dysfunction of mutant ST:STUDY_SUMMARY hearts and significantly extended the survival of mutant female mice affected by ST:STUDY_SUMMARY severe pregnancy-induced cardiomyopathy. Gene expression profiles confirmed that ST:STUDY_SUMMARY HFD increased fatty acid utilization and ameliorated cardiomyopathy markers. ST:STUDY_SUMMARY Importantly, HFD also decreased accumulation of aggregated CHCHD10 in the S55L ST:STUDY_SUMMARY heart, suggesting activation of quality control mechanisms. Overall, our ST:STUDY_SUMMARY findings indicate that metabolic therapy can be effective in mitochondrial ST:STUDY_SUMMARY cardiomyopathies associated with proteotoxic stress. ST:INSTITUTE Weill Cornell Medicine ST:LAST_NAME Southwell ST:FIRST_NAME Nneka ST:ADDRESS 407 E 61st St ST:EMAIL nns4001@med.cornell.edu ST:PHONE 646-962-8172 ST:SUBMIT_DATE 2024-03-06 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS HetCD_1 S_HetCD_1 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_HetCD_1.raw SUBJECT_SAMPLE_FACTORS HetCD_2 S_HetCD_2 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_HetCD_2.raw SUBJECT_SAMPLE_FACTORS HetCD_3 S_HetCD_3 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_HetCD_3.raw SUBJECT_SAMPLE_FACTORS HetCD_4 S_HetCD_4 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_HetCD_4.raw SUBJECT_SAMPLE_FACTORS HetCD_5 S_HetCD_5 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_HetCD_5.raw SUBJECT_SAMPLE_FACTORS HetCD_6 S_HetCD_6 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_HetCD_6.raw SUBJECT_SAMPLE_FACTORS HetCD_1 SL_HetCD_1 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_HetCD_1.raw SUBJECT_SAMPLE_FACTORS HetCD_2 SL_HetCD_2 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_HetCD_2.raw SUBJECT_SAMPLE_FACTORS HetCD_3 SL_HetCD_3 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_HetCD_3.raw SUBJECT_SAMPLE_FACTORS HetCD_4 SL_HetCD_4 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_HetCD_4.raw SUBJECT_SAMPLE_FACTORS HetCD_5 SL_HetCD_5 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_HetCD_5.raw SUBJECT_SAMPLE_FACTORS HetCD_6 SL_HetCD_6 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_HetCD_6.raw SUBJECT_SAMPLE_FACTORS HetCD_1 SP_HetCD_1 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_HetCD_1.raw SUBJECT_SAMPLE_FACTORS HetCD_2 SP_HetCD_2 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_HetCD_2.raw SUBJECT_SAMPLE_FACTORS HetCD_3 SP_HetCD_3 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_HetCD_3.raw SUBJECT_SAMPLE_FACTORS HetCD_4 SP_HetCD_4 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_HetCD_4.raw SUBJECT_SAMPLE_FACTORS HetCD_5 SP_HetCD_5 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_HetCD_5.raw SUBJECT_SAMPLE_FACTORS HetCD_6 SP_HetCD_6 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_HetCD_6.raw SUBJECT_SAMPLE_FACTORS HetHFD_1 S_HetHFD_1 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_HetHFD_1.raw SUBJECT_SAMPLE_FACTORS HetHFD_2 S_HetHFD_2 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_HetHFD_2.raw SUBJECT_SAMPLE_FACTORS HetHFD_3 S_HetHFD_3 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_HetHFD_3.raw SUBJECT_SAMPLE_FACTORS HetHFD_4 S_HetHFD_4 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_HetHFD_4.raw SUBJECT_SAMPLE_FACTORS HetHFD_5 S_HetHFD_5 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_HetHFD_5.raw SUBJECT_SAMPLE_FACTORS HetHFD_6 S_HetHFD_6 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_HetHFD_6.raw SUBJECT_SAMPLE_FACTORS HetHFD_1 SL_HetHFD_1 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_HetHFD_1.raw SUBJECT_SAMPLE_FACTORS HetHFD_2 SL_HetHFD_2 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_HetHFD_2.raw SUBJECT_SAMPLE_FACTORS HetHFD_3 SL_HetHFD_3 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_HetHFD_3.raw SUBJECT_SAMPLE_FACTORS HetHFD_4 SL_HetHFD_4 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_HetHFD_4.raw SUBJECT_SAMPLE_FACTORS HetHFD_5 SL_HetHFD_5 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_HetHFD_5.raw SUBJECT_SAMPLE_FACTORS HetHFD_6 SL_HetHFD_6 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_HetHFD_6.raw SUBJECT_SAMPLE_FACTORS HetHFD_1 SP_HetHFD_1 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_HetHFD_1.raw SUBJECT_SAMPLE_FACTORS HetHFD_2 SP_HetHFD_2 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_HetHFD_2.raw SUBJECT_SAMPLE_FACTORS HetHFD_3 SP_HetHFD_3 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_HetHFD_3.raw SUBJECT_SAMPLE_FACTORS HetHFD_4 SP_HetHFD_4 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_HetHFD_4.raw SUBJECT_SAMPLE_FACTORS HetHFD_5 SP_HetHFD_5 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_HetHFD_5.raw SUBJECT_SAMPLE_FACTORS HetHFD_6 SP_HetHFD_6 Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_HetHFD_6.raw SUBJECT_SAMPLE_FACTORS WTCD_1 SL_WTCD_1 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_WTCD_1.raw SUBJECT_SAMPLE_FACTORS WTCD_2 SL_WTCD_2 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_WTCD_2.raw SUBJECT_SAMPLE_FACTORS WTCD_3 SL_WTCD_3 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_WTCD_3.raw SUBJECT_SAMPLE_FACTORS WTCD_4 SL_WTCD_4 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_WTCD_4.raw SUBJECT_SAMPLE_FACTORS WTCD_5 SL_WTCD_5 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_WTCD_5.raw SUBJECT_SAMPLE_FACTORS WTCD_6 SL_WTCD_6 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_WTCD_6.raw SUBJECT_SAMPLE_FACTORS WTCD_1 SP_WTCD_1 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_WTCD_1.raw SUBJECT_SAMPLE_FACTORS WTCD_2 SP_WTCD_2 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_WTCD_2.raw SUBJECT_SAMPLE_FACTORS WTCD_3 SP_WTCD_3 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_WTCD_3.raw SUBJECT_SAMPLE_FACTORS WTCD_4 SP_WTCD_4 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_WTCD_4.raw SUBJECT_SAMPLE_FACTORS WTCD_5 SP_WTCD_5 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_WTCD_5.raw SUBJECT_SAMPLE_FACTORS WTCD_6 SP_WTCD_6 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_WTCD_6.raw SUBJECT_SAMPLE_FACTORS WTCD_1 S_WTCD_1 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_WTCD_1.raw SUBJECT_SAMPLE_FACTORS WTCD_2 S_WTCD_2 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_WTCD_2.raw SUBJECT_SAMPLE_FACTORS WTCD_3 S_WTCD_3 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_WTCD_3.raw SUBJECT_SAMPLE_FACTORS WTCD_4 S_WTCD_4 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_WTCD_4.raw SUBJECT_SAMPLE_FACTORS WTCD_5 S_WTCD_5 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_WTCD_5.raw SUBJECT_SAMPLE_FACTORS WTCD_6 S_WTCD_6 Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_WTCD_6.raw SUBJECT_SAMPLE_FACTORS WTHFD_1 SL_WTHFD_1 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_WTHFD_1.raw SUBJECT_SAMPLE_FACTORS WTHFD_2 SL_WTHFD_2 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_WTHFD_2.raw SUBJECT_SAMPLE_FACTORS WTHFD_3 SL_WTHFD_3 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_WTHFD_3.raw SUBJECT_SAMPLE_FACTORS WTHFD_4 SL_WTHFD_4 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_WTHFD_4.raw SUBJECT_SAMPLE_FACTORS WTHFD_5 SL_WTHFD_5 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_WTHFD_5.raw SUBJECT_SAMPLE_FACTORS WTHFD_6 SL_WTHFD_6 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SL_WTHFD_6.raw SUBJECT_SAMPLE_FACTORS WTHFD_1 SP_WTHFD_1 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_WTHFD_1.raw SUBJECT_SAMPLE_FACTORS WTHFD_2 SP_WTHFD_2 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_WTHFD_2.raw SUBJECT_SAMPLE_FACTORS WTHFD_3 SP_WTHFD_3 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_WTHFD_3.raw SUBJECT_SAMPLE_FACTORS WTHFD_4 SP_WTHFD_4 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_WTHFD_4.raw SUBJECT_SAMPLE_FACTORS WTHFD_5 SP_WTHFD_5 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_WTHFD_5.raw SUBJECT_SAMPLE_FACTORS WTHFD_6 SP_WTHFD_6 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=SP_WTHFD_6.raw SUBJECT_SAMPLE_FACTORS WTHFD_1 S_WTHFD_1 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_WTHFD_1.raw SUBJECT_SAMPLE_FACTORS WTHFD_2 S_WTHFD_2 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_WTHFD_2.raw SUBJECT_SAMPLE_FACTORS WTHFD_3 S_WTHFD_3 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_WTHFD_3.raw SUBJECT_SAMPLE_FACTORS WTHFD_4 S_WTHFD_4 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_WTHFD_4.raw SUBJECT_SAMPLE_FACTORS WTHFD_5 S_WTHFD_5 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_WTHFD_5.raw SUBJECT_SAMPLE_FACTORS WTHFD_6 S_WTHFD_6 Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F RAW_FILE_NAME(Raw File Name)=S_WTHFD_6.raw #COLLECTION CO:COLLECTION_SUMMARY Blood was collected by cheek bleeds into serum separator tubes. Serum was CO:COLLECTION_SUMMARY separated after 30 minutes of clotting at room temperature and centrifugation at CO:COLLECTION_SUMMARY 2000xg for 15 min. CO:SAMPLE_TYPE Blood (serum) #TREATMENT TR:TREATMENT_SUMMARY CHCHD10 WT and CHCHD10 S55L heterozygous mice were treated with either a control TR:TREATMENT_SUMMARY diet (70% Carbohydrate, 20% Protein, 10% Fat) or High Fat Diet (60% Fat, 20% TR:TREATMENT_SUMMARY Protein, 20% Carbohydrate). #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Untargeted and targeted metabolomics: Serum metabolites were extracted with 80% SP:SAMPLEPREP_SUMMARY methanol. The extracts were clarified by centrifugation at 15,000 g for 10 min. SP:SAMPLEPREP_SUMMARY The supernatant was collected and dried down using a SpeedVac. For lipidomics SP:SAMPLEPREP_SUMMARY analyses: 180 µl of 90% isopropanol was added to 20 µl serum. Samples were SP:SAMPLEPREP_SUMMARY vortexed for 2 min, sonicated for 1 min using a probe sonicator and centrifuged SP:SAMPLEPREP_SUMMARY at 15,000 g for 10 min. The supernatant was collected and dried down using a SP:SAMPLEPREP_SUMMARY SpeedVac. The dried samples were reconstituted using SP:SAMPLEPREP_SUMMARY acetonitrile/isopropanol/water 65:30:5 containing stable isotope labeled SP:SAMPLEPREP_SUMMARY internal lipid standards (Splash Lipidomix, Avanti Polar Lipids) prior to LC-MS SP:SAMPLEPREP_SUMMARY analysis. Free Fatty Acids: Free fatty acids were extracted from serum using 90% SP:SAMPLEPREP_SUMMARY methanol (LC/MS grade, Thermo Scientific). The extracts were clarified by SP:SAMPLEPREP_SUMMARY centrifugation at 15,000 g for 10 min. The supernatant was collected and dried SP:SAMPLEPREP_SUMMARY down using a SpeedVac. The dried sample was reconstituted using 50% methanol SP:SAMPLEPREP_SUMMARY prior to LC-MS analysis. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Serum lipidomics CH:METHODS_FILENAME Serum_MS_and_Data_Analysis.pdf CH:INSTRUMENT_NAME Thermo Vanquish CH:COLUMN_NAME Imtakt Cadenza CD-C18 (150 x 2.1 mm, 3um) CH:COLUMN_TEMPERATURE 35 CH:FLOW_GRADIENT 0–1.5 min, 32% B; 1.5-4 min, 32-45% B; 4-5 min, 45-52% B; 5-8 min, 52-58% B; CH:FLOW_GRADIENT 8-11 min, 58-66% B; 11-14 min, 66-70% B; 14-18 min, 70-75% B; 21-25 min, CH:FLOW_GRADIENT isocratic 97% B, 25-25.1 min 97-32% B CH:FLOW_RATE 200 µl/min CH:SOLVENT_A 60% acetonitrile/40% water; 10 mM ammonium formate; 0.1% formic acid CH:SOLVENT_B 90% isopropanol/10% acetonitrile; 10 mM ammonium formate; 0.1% formic acid CH:CHROMATOGRAPHY_TYPE Reversed phase #ANALYSIS AN:ANALYSIS_TYPE MS AN:ANALYSIS_PROTOCOL_FILE Serum_MS_and_Data_Analysis.pdf #MS MS:INSTRUMENT_NAME Thermo Q Exactive Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:MS_COMMENTS A data-dependent mass spectrometric acquisition method was used for lipid MS:MS_COMMENTS identification. In this method, each MS survey scan was followed by up to 10 MS:MS_COMMENTS MS/MS scans performed on the most abundant ions. The LC-MS results were MS:MS_COMMENTS processed using MS-DIAL software (version 4.9) for lipid identification and MS:MS_COMMENTS relative quantitation. MS:ION_MODE POSITIVE #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS Peak Intensity MS_METABOLITE_DATA_START Samples SL_HetCD_1 SL_HetCD_2 SL_HetCD_3 SL_HetCD_4 SL_HetCD_5 SL_HetCD_6 SL_HetHFD_1 SL_HetHFD_2 SL_HetHFD_3 SL_HetHFD_4 SL_HetHFD_5 SL_HetHFD_6 SL_WTCD_1 SL_WTCD_2 SL_WTCD_3 SL_WTCD_4 SL_WTCD_5 SL_WTCD_6 SL_WTHFD_1 SL_WTHFD_2 SL_WTHFD_3 SL_WTHFD_4 SL_WTHFD_5 SL_WTHFD_6 Factors Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:Control Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:CHCHD10 S55L Het | Treatment:High Fat Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:WT | Treatment:Control Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F Sample source:Serum | Genotype:WT | Treatment:High Fat Diet | Age (d):250 | Sex:F CE 16:0 480967.8000 799006.8000 650971.3000 728028.3000 602461.6000 525280.1000 891617.4000 634672.8000 714775.0000 745632.4000 1018522.0000 739908.6000 1000085.0000 734958.4000 948311.1000 701797.1000 1005337.0000 864286.6000 713640.1000 655212.4000 707542.7000 777939.2000 742440.3000 646903.5000 CE 18:2 122455400.0000 187165700.0000 142551600.0000 140139700.0000 144178200.0000 130627000.0000 228235100.0000 185172200.0000 202750800.0000 238998700.0000 206486900.0000 175269800.0000 131401500.0000 168297300.0000 286269000.0000 215498200.0000 152325900.0000 156888800.0000 170019300.0000 190343000.0000 205859200.0000 223360300.0000 225525600.0000 207723300.0000 CE 20:5 30998710.0000 43315740.0000 21890390.0000 23765890.0000 24966830.0000 16148660.0000 12956750.0000 7830496.0000 12998610.0000 14159650.0000 17238300.0000 8969120.0000 17722160.0000 36562680.0000 31844800.0000 22672540.0000 35289430.0000 27481140.0000 17153480.0000 14796600.0000 12432260.0000 16647740.0000 16787970.0000 15267760.0000 CE 22:5 5318807.0000 8053529.0000 8659895.0000 7524802.0000 6829305.0000 7413648.0000 6353033.0000 4058953.0000 5763478.0000 6039241.0000 7314345.0000 3419924.0000 7521638.0000 7174114.0000 9257749.0000 6559085.0000 9656591.0000 10690740.0000 7820879.0000 6831326.0000 6324001.0000 6729687.0000 7884183.0000 6802057.0000 CE 22:6 201352800.0000 250167900.0000 202484900.0000 183856600.0000 183686900.0000 162764500.0000 200691800.0000 135089900.0000 201749900.0000 214725600.0000 212861400.0000 95684860.0000 188652600.0000 258125200.0000 237383000.0000 156661800.0000 278022000.0000 328661300.0000 300462700.0000 259068400.0000 301014100.0000 363208200.0000 257559600.0000 301726400.0000 Cer 42:0;2O 327757.4000 316305.2000 342452.7000 409498.1000 408681.0000 327883.1000 753221.2000 603728.4000 807554.3000 1001075.0000 2369573.0000 1096322.0000 471128.8000 421931.0000 548518.9000 458720.2000 525537.0000 546987.0000 907888.0000 1157775.0000 737404.2000 681708.0000 1009273.0000 1087638.0000 Cer 42:1;3O 171565.5000 181667.4000 207113.6000 196751.7000 244269.4000 209731.0000 800707.9000 526787.8000 735396.5000 625474.8000 1071476.0000 853713.7000 337966.7000 249372.3000 423398.6000 470766.2000 336131.6000 329619.3000 960394.3000 1490289.0000 660227.8000 708125.6000 1097052.0000 1063764.0000 Cer 42:2;2O 2028683.0000 2427034.0000 2969505.0000 2285942.0000 2688437.0000 2649427.0000 2810062.0000 2026896.0000 2827519.0000 2740458.0000 5333654.0000 2275732.0000 3127003.0000 2735732.0000 3899938.0000 4081241.0000 4270836.0000 4179646.0000 6404734.0000 7369339.0000 3043907.0000 3900354.0000 4151990.0000 4868778.0000 Cer 42:3;2O 135679.0000 177385.4000 216132.1000 168310.2000 158608.8000 169277.8000 257844.2000 166318.8000 259344.6000 257609.3000 508329.4000 202691.0000 182089.5000 180848.4000 426077.8000 430564.1000 220540.8000 224179.5000 467702.2000 604979.7000 251736.0000 353890.1000 341308.4000 454775.1000 Cer 43:0;2O 149033.6000 156503.5000 160920.3000 171485.8000 162120.9000 175307.4000 197124.7000 194905.9000 350379.2000 1254035.0000 362632.9000 137717.3000 139645.0000 162605.0000 169467.2000 158109.8000 209616.5000 339046.3000 209012.7000 176803.9000 231407.8000 229652.7000 Cer 44:0;2O 283069.0000 285461.6000 291650.5000 327844.7000 312060.8000 249503.0000 302528.2000 307498.5000 321757.2000 527798.3000 1824816.0000 517345.0000 278435.4000 276166.9000 298903.7000 246933.9000 278035.9000 297247.0000 334045.3000 421347.7000 335868.0000 322751.9000 307401.8000 334597.7000 Cer 44:0;3O 466473.7000 397935.8000 378666.3000 396050.1000 417424.2000 386560.3000 329393.8000 343844.0000 392641.6000 489531.3000 868001.4000 545602.0000 294503.3000 405508.3000 407666.2000 309969.8000 421030.0000 394641.8000 498471.2000 502235.5000 450703.8000 439555.9000 485743.3000 481103.5000 Cer 44:0;4O 270445.8000 262646.5000 246873.9000 263386.0000 257100.3000 214535.6000 227683.7000 215532.5000 242585.4000 251186.1000 274003.7000 264819.1000 237646.2000 229796.5000 270036.6000 211945.4000 243207.9000 254383.7000 286648.8000 278737.6000 258624.3000 284779.9000 278286.3000 284048.0000 Cer 44:1;2O 168911.9000 175996.4000 168033.3000 196413.6000 153162.8000 152442.6000 183108.5000 188090.0000 163798.5000 266453.2000 1298361.0000 309942.4000 165169.7000 162063.2000 156364.0000 125417.5000 163779.6000 172752.1000 213343.3000 253661.6000 222773.6000 197041.9000 207113.8000 206938.7000 Cer 44:1;3O 41740.5100 37742.6400 43473.1100 41217.6400 50760.7100 36016.0100 81998.8200 60604.0200 71296.2000 88548.5200 466781.8000 106148.9000 43655.4600 39692.9200 46113.0300 62583.1900 45008.2500 33558.2900 84768.5300 107629.7000 73434.3500 63240.8100 76889.9700 97554.3600 Cer 46:0;3O 517511.7000 496743.9000 517076.2000 538565.8000 503022.8000 434446.9000 465459.3000 472521.0000 474696.4000 491648.3000 525260.2000 543827.3000 467310.0000 450289.7000 512213.1000 430504.4000 507469.0000 518880.0000 568294.9000 492032.1000 526916.4000 519302.5000 530710.0000 519955.8000 Cer 46:0;4O 322084.6000 258805.3000 265916.2000 318163.1000 262292.8000 238004.2000 253272.2000 256276.5000 284000.0000 274669.9000 252795.4000 286328.8000 186151.2000 260661.4000 263308.8000 259714.1000 279825.8000 298199.4000 335387.6000 299126.9000 289584.9000 288722.9000 279252.1000 307780.5000 DG 34:3 98700.3100 233800.5000 119733.9000 90097.7700 122785.5000 77839.2700 120849.2000 128171.0000 111961.1000 204269.5000 321174.9000 170703.6000 71527.9300 55136.6200 403250.2000 488512.2000 18927.5200 48270.7100 130761.6000 133437.7000 44158.0700 55066.4500 153606.8000 102523.7000 DG 36:0 1538279.0000 1694662.0000 1724943.0000 2007311.0000 1530714.0000 1711468.0000 1556451.0000 1593997.0000 1461918.0000 1517863.0000 1745930.0000 1577043.0000 1588917.0000 1458963.0000 1471267.0000 1282001.0000 1484725.0000 1517030.0000 1427443.0000 1401006.0000 1368817.0000 1431019.0000 1475702.0000 1618117.0000 DG 36:4 297543.5000 748371.0000 276049.2000 240679.0000 336415.7000 154555.7000 497836.3000 677204.5000 686453.6000 1116278.0000 1725649.0000 1029701.0000 377598.2000 254436.4000 768399.4000 893877.9000 168164.1000 217166.9000 251525.3000 564006.3000 239578.9000 353563.8000 582257.0000 618639.8000 DG 38:2 95596.2100 229091.4000 188523.5000 203980.5000 230375.2000 209518.5000 163489.4000 150499.2000 122755.3000 165557.4000 543688.4000 268617.0000 140887.2000 103896.4000 707521.5000 843033.1000 94854.7300 121485.0000 137307.2000 309345.9000 89701.0200 81848.2300 271065.1000 165036.7000 DG 38:6 112104.8000 295595.3000 147818.4000 93123.4900 125962.0000 94180.6600 783958.3000 704158.5000 681838.1000 756630.4000 1178339.0000 845385.1000 121669.8000 76919.2300 260720.8000 215107.3000 45346.7500 121477.0000 710415.9000 860208.6000 462581.5000 795594.6000 725256.3000 743941.6000 DG 41:0 216676.9000 218437.0000 242503.7000 252805.6000 202973.1000 213878.7000 175199.7000 168658.9000 196987.7000 247097.8000 203336.1000 215495.5000 143703.6000 186779.9000 188877.3000 130409.1000 214173.3000 225661.6000 249781.3000 183601.6000 191992.3000 183401.8000 201576.4000 207647.5000 DG 50:2 521015.5000 501129.6000 543095.9000 361576.5000 435593.5000 564166.9000 304328.9000 237708.8000 525000.7000 473134.3000 452216.5000 567699.6000 1540274.0000 340888.5000 1920545.0000 2041545.0000 470069.7000 633397.1000 266056.7000 578463.3000 341766.3000 273625.1000 911249.3000 328944.1000 DG O-31:1 264779.0000 251558.8000 244557.5000 308818.1000 292669.9000 254521.8000 262414.3000 267237.9000 309347.9000 283712.5000 319594.6000 332367.5000 316059.8000 266765.5000 333963.1000 307956.5000 315811.7000 360327.5000 248780.7000 314879.4000 309800.0000 326672.2000 311992.2000 300845.3000 DG O-36:0 45804.8600 62355.1500 80125.6000 66736.1800 104038.7000 75748.5900 127180.1000 91092.8400 111078.8000 161868.1000 905134.8000 441363.3000 33628.0100 29845.1700 132792.2000 72096.9400 78168.5600 84259.7000 197777.1000 178579.4000 65225.7000 164212.1000 182905.3000 HexCer 36:1;2O 538842.2000 741512.0000 767309.4000 612854.9000 804261.2000 1044897.0000 1534584.0000 1033832.0000 1646845.0000 1748119.0000 424770.3000 233195.0000 895855.1000 707611.8000 66166.9800 1356950.0000 1134793.0000 3273636.0000 677503.6000 1844482.0000 2707914.0000 2916007.0000 2340973.0000 HexCer 40:1;2O 1530089.0000 1923389.0000 1956261.0000 1864347.0000 1932754.0000 1908671.0000 2386547.0000 1874627.0000 2626005.0000 2482566.0000 5368684.0000 2340339.0000 1921613.0000 1837789.0000 4777923.0000 4238177.0000 1543400.0000 2038041.0000 3164150.0000 9032899.0000 2589685.0000 3202582.0000 6738477.0000 3236376.0000 HexCer 42:1;2O 1305833.0000 1648364.0000 1862284.0000 1800037.0000 1668178.0000 1928871.0000 1834903.0000 1554046.0000 1960245.0000 1987918.0000 1499790.0000 1074558.0000 1829340.0000 1702492.0000 1787140.0000 1825473.0000 1377243.0000 1669787.0000 2170102.0000 1922987.0000 2090625.0000 2221330.0000 1527127.0000 2331285.0000 LPC 14:0 2025674.0000 2967416.0000 3251731.0000 2485046.0000 2892930.0000 2908310.0000 1996720.0000 1304214.0000 1511691.0000 1525492.0000 1790923.0000 1469432.0000 2888122.0000 3127815.0000 3479563.0000 3589481.0000 3345512.0000 3355551.0000 1831674.0000 1654028.0000 1299013.0000 1485531.0000 1128758.0000 1727680.0000 LPC 16:0 811252700.0000 958416300.0000 990694500.0000 953078800.0000 935296300.0000 1019496000.0000 1062908000.0000 776572000.0000 997517800.0000 1002149000.0000 1198712000.0000 927670400.0000 1016009000.0000 1017667000.0000 1494632000.0000 1424459000.0000 1396425000.0000 1326321000.0000 1664029000.0000 1489369000.0000 1108470000.0000 1231901000.0000 1123779000.0000 1326734000.0000 LPC 17:1 1315559.0000 1951100.0000 2263917.0000 1951047.0000 2138457.0000 2172183.0000 2030941.0000 1225274.0000 1393025.0000 1150412.0000 2228598.0000 1928744.0000 2299918.0000 2493153.0000 3932152.0000 3453570.0000 2295277.0000 2830815.0000 2255100.0000 2640850.0000 1202346.0000 1329604.0000 1762539.0000 1806106.0000 LPC 18:0 374129300.0000 607641500.0000 447149000.0000 446570000.0000 486886000.0000 521365700.0000 806179000.0000 562401200.0000 893777300.0000 855337000.0000 707840500.0000 533714900.0000 534233300.0000 466803100.0000 516868400.0000 433323000.0000 572806000.0000 555966800.0000 1224818000.0000 1107383000.0000 986280600.0000 1137505000.0000 720855700.0000 1126114000.0000 LPC 18:1 325909900.0000 477261900.0000 553309400.0000 440619000.0000 488482200.0000 539051600.0000 399844300.0000 250252800.0000 283970800.0000 254970400.0000 399524000.0000 352572000.0000 535867700.0000 597084800.0000 731522000.0000 602161900.0000 692560500.0000 639517100.0000 540786800.0000 495318400.0000 300827100.0000 309076400.0000 340300700.0000 378633500.0000 LPC 18:2 443250700.0000 592994800.0000 575296500.0000 565969600.0000 610031000.0000 606988900.0000 1208112000.0000 886302700.0000 937164400.0000 730081200.0000 973079000.0000 960258000.0000 709411100.0000 624408100.0000 897922500.0000 785325000.0000 554295200.0000 752243500.0000 1005086000.0000 1287854000.0000 746918000.0000 790652400.0000 934423500.0000 949397000.0000 LPC 19:2 188583.1000 202546.9000 170038.7000 172066.1000 174958.4000 180449.7000 178737.3000 119509.3000 127283.6000 125784.3000 218613.1000 198206.0000 180974.9000 196362.1000 363009.9000 296382.1000 191826.6000 221127.4000 240654.8000 266339.6000 116306.6000 166962.5000 186861.3000 204300.1000 LPC 20:0 650361.6000 956031.1000 713358.4000 685368.0000 634953.6000 627659.1000 792940.5000 588743.7000 792689.3000 847782.3000 3488256.0000 2103706.0000 713251.7000 665859.1000 6237492.0000 6466764.0000 614250.4000 663484.0000 801136.2000 4605851.0000 701349.2000 824038.0000 4594681.0000 910938.2000 LPC 20:1 4647077.0000 8355694.0000 6472843.0000 6177707.0000 5487467.0000 6519768.0000 3959495.0000 3057392.0000 3931005.0000 3546017.0000 9046432.0000 6927916.0000 5662353.0000 5418390.0000 20440140.0000 16200530.0000 5564987.0000 4883746.0000 7067933.0000 10713180.0000 4301401.0000 4605808.0000 6445234.0000 5555206.0000 LPC 22:0 347960.2000 495051.2000 427654.5000 375176.0000 371816.5000 369220.9000 599479.1000 424494.3000 554439.6000 644409.7000 926530.6000 569043.1000 388524.5000 396925.2000 958640.7000 866825.6000 380007.4000 435683.3000 487298.6000 827703.8000 495160.5000 548022.9000 723804.3000 665809.5000 LPC 23:0 95185.8300 124728.3000 114810.1000 94962.1000 92580.3500 91011.9800 139438.8000 96803.9500 118380.4000 143258.5000 204179.9000 121618.7000 98200.6500 99105.3300 222426.3000 154151.1000 99866.8800 96862.7400 109105.1000 152236.3000 109022.6000 119459.8000 122371.1000 139526.5000 LPC 24:0 528000.1000 742779.6000 714829.9000 626909.9000 581737.1000 555879.3000 976498.8000 642071.3000 827499.9000 866368.3000 1337800.0000 691965.3000 626889.1000 667071.6000 1246480.0000 1024958.0000 615778.6000 720541.1000 891543.1000 1139923.0000 773297.8000 880041.5000 868652.0000 994271.3000 LPE 16:0 2369366.0000 2612287.0000 2388208.0000 2072116.0000 2377573.0000 2209673.0000 2396979.0000 2217096.0000 1822445.0000 2256638.0000 2650416.0000 1941277.0000 2520829.0000 2372565.0000 2928738.0000 3181327.0000 2852831.0000 2715257.0000 2838833.0000 2463917.0000 2386527.0000 2481134.0000 2144889.0000 2618248.0000 LPE 20:3 175162.2000 331745.3000 212446.5000 226786.9000 221691.8000 242709.9000 250904.5000 234549.3000 236169.8000 169545.7000 234463.5000 298422.3000 196143.4000 255599.7000 434235.1000 385588.2000 287329.7000 202860.5000 294085.4000 475977.5000 189961.5000 255656.8000 379233.2000 289895.3000 LPE 20:4 5603826.0000 9046145.0000 5982193.0000 5675614.0000 5221114.0000 6450637.0000 9964935.0000 8460093.0000 7764394.0000 5438827.0000 6605215.0000 9923980.0000 6449772.0000 7298304.0000 8261325.0000 7560942.0000 9037022.0000 7257469.0000 11338100.0000 12360550.0000 8015791.0000 9304403.0000 9951158.0000 10586220.0000 LPE O-16:1 130701.1000 222544.7000 164481.1000 178453.3000 148165.8000 143201.4000 180597.5000 149195.6000 252844.8000 263794.3000 416702.3000 229976.1000 216198.5000 167655.8000 364539.7000 377936.5000 201116.7000 202152.7000 241750.2000 430800.8000 230766.2000 269599.0000 222227.5000 327573.0000 LPE O-18:2 88067.0600 102424.7000 94862.2600 94854.9500 72325.4200 79388.0900 83340.4500 73717.3000 118188.5000 138640.2000 154087.6000 117098.1000 117559.2000 79364.1600 181283.5000 212689.2000 101420.4000 111551.4000 118522.4000 220680.4000 114352.6000 139315.8000 104550.4000 176135.5000 PC 30:0 1582016.0000 2119445.0000 2345668.0000 1768573.0000 2009546.0000 1807498.0000 2603555.0000 1856401.0000 2128117.0000 3090859.0000 4431714.0000 2601225.0000 2231466.0000 2623212.0000 3491243.0000 3017384.0000 2978867.0000 3147107.0000 3068017.0000 3813836.0000 2093407.0000 2829310.0000 2523740.0000 3042221.0000 PC 32:0 56764530.0000 77607270.0000 84578540.0000 66522800.0000 65414300.0000 68468110.0000 103837400.0000 70715610.0000 80725340.0000 110139200.0000 211501800.0000 98634530.0000 88392780.0000 81535170.0000 114292500.0000 109757900.0000 114191900.0000 115145000.0000 196825500.0000 167226000.0000 92192310.0000 129959800.0000 121293800.0000 145391000.0000 PC 32:1 19355280.0000 27038290.0000 41415830.0000 23557510.0000 31321200.0000 24177650.0000 23890550.0000 14214280.0000 13808420.0000 13271600.0000 34896420.0000 19005240.0000 30561720.0000 50961600.0000 124315000.0000 129218700.0000 46750640.0000 52194780.0000 25566590.0000 31016500.0000 13378620.0000 14462530.0000 25466430.0000 19485730.0000 PC 32:2 1301532.0000 1753673.0000 2087548.0000 1358082.0000 1563220.0000 1327905.0000 2095773.0000 1355004.0000 1254769.0000 1240566.0000 4201182.0000 1789523.0000 1887350.0000 2118212.0000 5485568.0000 5770746.0000 1560851.0000 1759370.0000 2287932.0000 3132772.0000 1090285.0000 1322242.0000 2363626.0000 1906923.0000 PC 33:0 650663.4000 933297.1000 885740.8000 1062527.0000 831305.5000 854522.3000 1382612.0000 1161718.0000 1366499.0000 2049072.0000 3009684.0000 1510985.0000 969894.8000 905613.5000 1419786.0000 1564516.0000 935160.5000 1487373.0000 2357722.0000 2798804.0000 1380289.0000 1732988.0000 1959930.0000 2602091.0000 PC 33:1 4426526.0000 5336393.0000 8283427.0000 6244406.0000 7952101.0000 7480140.0000 8169205.0000 5208149.0000 5161598.0000 5660641.0000 17330150.0000 8723291.0000 7486378.0000 9830426.0000 22721180.0000 21939540.0000 9765982.0000 14841070.0000 10640480.0000 16367610.0000 5097862.0000 6568131.0000 12849730.0000 9333477.0000 PC 33:2 1844678.0000 2194183.0000 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100557.2000 96844.8900 272056.3000 295589.4000 72770.5200 96921.6200 152426.8000 214426.6000 90153.2300 139010.4000 140679.1000 139303.0000 PI 40:5 107521.2000 157130.3000 156928.3000 249310.5000 429139.9000 361182.2000 441760.8000 246671.7000 435644.6000 472286.9000 PI 40:6 343086.8000 318741.5000 454231.0000 494016.3000 264351.7000 426805.9000 438785.9000 332369.8000 435950.2000 428894.5000 732043.0000 298350.2000 437663.2000 294397.9000 1032298.0000 749526.3000 295779.2000 272506.6000 573380.1000 1011740.0000 278790.7000 514952.3000 563959.2000 676892.8000 SM 33:1;3O 138448.3000 169975.8000 173801.5000 135833.8000 139419.8000 138593.9000 300724.0000 198761.0000 259950.0000 294206.8000 296286.8000 135398.0000 159432.0000 176412.9000 191311.7000 128347.9000 159477.2000 165229.9000 299580.2000 220612.7000 280066.4000 328766.8000 211694.1000 402822.8000 SM 34:0;2O 1407562.0000 1866943.0000 1591295.0000 2049624.0000 1619540.0000 1450077.0000 4719388.0000 2734732.0000 4316899.0000 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2997216.0000 3729966.0000 2674420.0000 1638230.0000 1142917.0000 1032626.0000 926732.2000 823282.6000 1094628.0000 1351738.0000 3515210.0000 2354206.0000 3270658.0000 4489895.0000 2289863.0000 4283103.0000 SM 35:2;2O 66746.2500 94975.6100 77817.2700 62784.6000 50079.4600 70627.6600 184962.7000 122739.2000 163526.6000 158278.6000 249685.0000 115624.5000 81311.4200 73054.8900 113258.0000 89125.3400 55882.7800 71918.6600 175395.7000 233461.2000 203108.5000 277753.7000 195707.0000 281641.3000 SM 36:0;2O 205698.9000 340975.3000 249650.3000 255031.9000 341759.0000 289228.1000 841569.3000 488857.2000 806795.6000 1344378.0000 885031.4000 310085.4000 249624.7000 367241.4000 177231.6000 179812.9000 429438.4000 432610.7000 1788772.0000 823284.2000 1088792.0000 2021989.0000 526833.1000 1326266.0000 SM 36:1;2O 12444300.0000 19832120.0000 13622100.0000 15597580.0000 13638250.0000 16382420.0000 41212570.0000 28409280.0000 46955890.0000 56632980.0000 24628170.0000 16876280.0000 16328630.0000 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113378.3000 480141.5000 356744.5000 367087.9000 563027.1000 336246.4000 604868.8000 SM 37:1;2O 238703.8000 501170.7000 279281.0000 278624.0000 247071.6000 215965.2000 863086.4000 729942.9000 852992.2000 1073863.0000 2207805.0000 778953.6000 339664.5000 294966.0000 545743.4000 399409.9000 298640.1000 318242.3000 1278787.0000 2459423.0000 946584.4000 1531636.0000 2414907.0000 1427501.0000 SM 38:2;3O 992250.9000 1496047.0000 1019613.0000 952598.6000 1066988.0000 851681.2000 2104841.0000 1290100.0000 1845913.0000 1909894.0000 2264577.0000 2370713.0000 1147719.0000 1087942.0000 2571409.0000 2252117.0000 978670.6000 1201488.0000 1327019.0000 2417256.0000 1376816.0000 1813523.0000 2508160.0000 2140126.0000 SM 38:4;2O 963030.8000 1761225.0000 1088928.0000 781006.3000 985419.4000 1284751.0000 2375726.0000 1670995.0000 2226095.0000 3851547.0000 1435260.0000 894895.3000 952857.8000 869649.1000 1163414.0000 1104673.0000 3514599.0000 867064.7000 3398204.0000 6442034.0000 3548562.0000 SM 38:5;3O 2702519.0000 3261189.0000 3729412.0000 3042858.0000 2724558.0000 3335275.0000 8015649.0000 3938752.0000 6582999.0000 7950418.0000 9192772.0000 6474131.0000 4701232.0000 5362665.0000 5351429.0000 4490288.0000 5055879.0000 4994192.0000 7464408.0000 12344520.0000 7207886.0000 7681546.0000 8677019.0000 8568126.0000 SM 39:1;2O 822190.9000 1251512.0000 937066.1000 986611.8000 838154.1000 828926.3000 1873891.0000 1453202.0000 1831062.0000 2486811.0000 6501367.0000 2939746.0000 882823.1000 939287.6000 4014940.0000 3551606.0000 683188.3000 864861.9000 1732161.0000 7343094.0000 1773921.0000 2167906.0000 9263597.0000 2351914.0000 SM 39:9;3O 382476.3000 448508.6000 513374.0000 502968.8000 420648.8000 401714.6000 694605.9000 374273.2000 436415.0000 1025002.0000 1722601.0000 640952.9000 587983.3000 597779.3000 876574.7000 730359.7000 870062.8000 669313.2000 1328753.0000 1389049.0000 654636.3000 899059.7000 925276.3000 1014908.0000 SM 42:1;2O 7913018.0000 12611900.0000 7672984.0000 8925955.0000 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898854.2000 1082530.0000 3350436.0000 2493296.0000 2661455.0000 2685298.0000 1254105.0000 1156755.0000 1420480.0000 1131633.0000 191843.1000 119775.5000 1411068.0000 1141171.0000 7655440.0000 1472391.0000 4914031.0000 6376411.0000 564146.0000 5914801.0000 SM 42:7;2O 418364.6000 669515.4000 269739.3000 255313.8000 237044.0000 265612.9000 548828.8000 389763.4000 442243.2000 499350.8000 167306.0000 210982.2000 324153.7000 318746.3000 366012.4000 230017.9000 1126398.0000 183735.4000 785102.0000 924271.5000 116188.3000 793299.1000 SM 42:7;3O 2117529.0000 3479585.0000 2196935.0000 2431907.0000 1848944.0000 2208966.0000 4838635.0000 3494512.0000 4569661.0000 3646651.0000 5398411.0000 3542589.0000 2836319.0000 2722857.0000 5230991.0000 4212349.0000 2826518.0000 3434413.0000 5014249.0000 6025302.0000 3424523.0000 6149846.0000 5411189.0000 6162275.0000 SM 43:6;2O 275992.3000 194915.0000 180091.2000 233758.5000 208842.3000 273869.3000 363309.8000 432313.6000 478661.6000 380233.7000 433198.1000 371883.8000 308473.2000 228435.7000 311570.7000 326177.9000 181865.4000 240935.8000 293940.6000 369752.3000 346787.7000 423614.1000 320175.1000 434017.2000 SM 43:7;2O 616697.9000 581401.8000 631473.0000 697743.9000 632441.4000 603101.4000 561170.4000 469261.9000 519368.3000 719937.6000 539673.6000 799791.1000 514255.5000 568426.4000 636076.0000 485703.5000 631368.3000 654324.7000 313531.8000 531701.4000 511352.3000 581069.4000 661184.1000 377341.6000 SM 48:7;2O 431803.8000 647114.8000 369892.9000 390419.1000 836990.3000 SM 60:3;3O 325981.7000 547534.8000 345598.7000 476233.8000 360527.4000 294451.7000 436265.9000 331155.5000 681031.6000 514826.6000 353123.4000 469902.3000 311569.0000 294002.5000 466421.3000 411430.9000 225458.9000 373511.5000 415857.2000 531858.3000 457368.3000 581641.8000 359373.8000 627608.6000 SM 60:4;3O 361650.3000 627375.8000 417540.7000 415561.7000 319396.7000 320131.7000 398913.9000 311464.9000 422116.7000 498949.1000 403109.9000 402452.7000 368781.7000 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525483.4000 154736.1000 483071.1000 424413.9000 698060.5000 54912.2600 70360.5600 215715.6000 357596.0000 39627.1000 66565.8000 80036.5900 274289.5000 70844.7900 56538.0100 390503.7000 192223.4000 TG 52:3;1O 79301.3400 106114.8000 78844.8800 95237.7300 121145.8000 74122.7500 313271.1000 520243.4000 144736.8000 436337.2000 416079.5000 660709.2000 142430.7000 81812.9100 218051.4000 418066.2000 55020.0900 93480.1300 71084.1000 251651.5000 66229.2000 70209.7300 331153.4000 194479.3000 TG 52:4 84548910.0000 257235900.0000 89601460.0000 87865160.0000 91780000.0000 78146500.0000 154026900.0000 276696300.0000 196183800.0000 215440000.0000 270455700.0000 324377800.0000 68521700.0000 59831260.0000 257765000.0000 324383800.0000 22360190.0000 47544360.0000 79110220.0000 155030600.0000 74573820.0000 89866650.0000 228710300.0000 178038200.0000 TG 52:5;2O 1298646.0000 2325949.0000 1753732.0000 1251217.0000 2135075.0000 1369836.0000 3928156.0000 4752632.0000 4441753.0000 4401613.0000 5531292.0000 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17451560.0000 16509670.0000 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name pubchem_id inchi_key kegg_id other_id other_id_type ri ri_type moverz_quant CE 16:0 CE 18:2 CE 20:5 CE 22:5 CE 22:6 Cer 42:0;2O Cer 42:1;3O Cer 42:2;2O Cer 42:3;2O Cer 43:0;2O Cer 44:0;2O Cer 44:0;3O Cer 44:0;4O Cer 44:1;2O Cer 44:1;3O Cer 46:0;3O Cer 46:0;4O DG 34:3 DG 36:0 DG 36:4 DG 38:2 DG 38:6 DG 41:0 DG 50:2 DG O-31:1 DG O-36:0 HexCer 36:1;2O HexCer 40:1;2O HexCer 42:1;2O LPC 14:0 LPC 16:0 LPC 17:1 LPC 18:0 LPC 18:1 LPC 18:2 LPC 19:2 LPC 20:0 LPC 20:1 LPC 22:0 LPC 23:0 LPC 24:0 LPE 16:0 LPE 20:3 LPE 20:4 LPE O-16:1 LPE O-18:2 PC 30:0 PC 32:0 PC 32:1 PC 32:2 PC 33:0 PC 33:1 PC 33:2 PC 34:0 PC 34:4 PC 35:0 PC 35:1 PC 35:4 PC 36:3 PC 36:6 PC 37:1 PC 38:1 PC 38:2 PC 38:3 PC 38:7 PC 39:6 PC 40:8 PC 41:6 PC 41:7 PC 42:1 PC 42:10 PC 42:8 PC 42:9 PC 44:12 PC 44:4 PC 44:5 PC 44:6 PC O-32:0 PC O-32:1 PC O-32:2 PC O-34:0 PC O-34:1 PC O-34:2 PC O-34:3 PC O-34:4 PC O-36:1 PC O-36:4 PC O-36:5 PC O-40:1 PC O-40:6 PC O-40:7 PC O-40:8 PC O-40:9 PC O-42:4 PC O-42:5 PC O-42:6 PC O-42:7 PC O-44:5 PE 34:1 PE 34:2 PE 36:1 PE 36:2 PE 36:3 PE 36:4 PE 38:4 PE 38:6 PE P-36:4 PI 34:1 PI 34:2 PI 36:2 PI 36:3 PI 38:5 PI 38:6 PI 40:5 PI 40:6 SM 33:1;3O SM 34:0;2O SM 34:1;2O SM 34:2;2O SM 35:1;2O SM 35:2;2O SM 36:0;2O SM 36:1;2O SM 36:2;2O SM 36:2;3O SM 36:3;2O SM 37:1;2O SM 38:2;3O SM 38:4;2O SM 38:5;3O SM 39:1;2O SM 39:9;3O SM 42:1;2O SM 42:1;3O SM 42:2;2O SM 42:5;2O SM 42:7;2O SM 42:7;3O SM 43:6;2O SM 43:7;2O SM 48:7;2O SM 60:3;3O SM 60:4;3O TG 34:0 TG 39:1;1O TG 40:0 TG 40:1 TG 40:1;1O TG 41:0 TG 41:1;1O TG 42:0 TG 42:1 TG 42:2 TG 43:0 TG 43:1 TG 43:1;1O TG 43:2;1O TG 44:0 TG 44:1 TG 44:2 TG 44:3 TG 45:2 TG 47:2 TG 48:2 TG 48:3 TG 48:4 TG 49:2 TG 49:3 TG 49:4 TG 50:0 TG 50:1 TG 50:2 TG 50:3 TG 50:4 TG 52:0 TG 52:1 TG 52:1;1O TG 52:2;1O TG 52:3;1O TG 52:4 TG 52:5;2O TG 53:0 TG 53:1 TG 53:2 TG 53:3 TG 53:4 TG 54:3 TG 54:4 TG 54:4;1O TG 54:5 TG 54:6 TG 54:7 TG 54:8 TG 55:0 TG 55:1 TG 55:2 TG 55:3 TG 55:4 TG 55:5 TG 56:1 TG 56:2 TG 56:3 TG 56:4 TG 56:5 TG 56:6 TG 56:7 TG 56:8 TG 56:9 TG 57:0 TG 57:8 TG 58:7 METABOLITES_END #END