{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST003643","ANALYSIS_ID":"AN005982","PROJECT_ID":"PR002253","VERSION":"1","CREATED_ON":"December 30, 2024, 9:51 pm"},

"PROJECT":{"PROJECT_TITLE":"Metabolite analysis for WT and BnaMYB52 mutants by LC-MS/MS","PROJECT_TYPE":"LC-MS/MS","PROJECT_SUMMARY":"BnaA09.MYB52 directly targets the BnaBAN promoters and promotes BnaBAN expression in B. napus. BAN, encoding anthocyanidin reductase that converts anthocyanidins to 2,3- cis-flavan-3-ols compounds (proanthocyanidins starter units), is involved in the flavonoid biosynthesis pathway. Thus, Metabolite analysis was conducted to detect the content of flavonoid in WT (Wild-type), OE (BnaA09.MYB52 overexpression lines in the genetic background Westar) and mutants (four homologous genes of BnaMYB52 knocked out) plants. The result showed that the content of several metabolites in flavonoid pathway was reduced in mutants, whereas overexpression lines resulted in the opposite trend compared with WT.","INSTITUTE":"Huazhong Agricultural University","LAST_NAME":"Jiang","FIRST_NAME":"Ye","ADDRESS":"Shi Zishan Street 1th, Wuhan, Hubei, 430070, China","EMAIL":"vyejiang@163.com","PHONE":"13697353446","PUBLICATIONS":"Ye et al. Manipulation of seed coat content for increasing oil content via modulating BnaMYB52 in Brassica napus. Cell reports"},

"STUDY":{"STUDY_TITLE":"Metabolite analysis for WT and BnaMYB52 mutants by LC-MS/MS","STUDY_SUMMARY":"BnaA09.MYB52 directly targets the BnaBAN promoters and promotes BnaBAN expression in Brassica napus. BAN, encoding anthocyanidin reductase that converts anthocyanidins to 2,3- cis-flavan-3-ols compounds (proanthocyanidins starter units), is involved in the flavonoid biosynthesis pathway. Thus, Metabolite analysis was conducted to detect the content of flavonoid in WT (Wild-type), OE (BnaA09.MYB52 overexpression lines in the genetic background Westar) and mutants (four homologous genes of BnaMYB52 knocked out) plants. About 0.1 g mature seeds were collected from WT, OE and mutant plants. Metabolites analysis demonstrated that BnaMYB52 positively regulated the content of several metabolites (such as L-phenylalanine, p-coumaric acid, grosvenorine and astragalin) in flavonoid pathway.","INSTITUTE":"Huazhong Agricultural University","LAST_NAME":"Jiang","FIRST_NAME":"Ye","ADDRESS":"Shi Zishan Street 1th, Wuhan, Hubei, 430070, China","EMAIL":"vyejiang@163.com","PHONE":"13697353446"},

"SUBJECT":{"SUBJECT_TYPE":"Plant","SUBJECT_SPECIES":"Brassica napus","TAXONOMY_ID":"3708"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"19-1-1",
"Sample ID":"WT-1",
"Factors":{"Sample source":"Mature seeds","Genotype":"Wide-type"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-2",
"Sample ID":"WT-2",
"Factors":{"Sample source":"Mature seeds","Genotype":"Wide-type"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-3",
"Sample ID":"WT-3",
"Factors":{"Sample source":"Mature seeds","Genotype":"Wide-type"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-4",
"Sample ID":"WT-4",
"Factors":{"Sample source":"Mature seeds","Genotype":"Wide-type"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-5",
"Sample ID":"52CR-1-1",
"Factors":{"Sample source":"Mature seeds","Genotype":"Mutant"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-6",
"Sample ID":"52CR-1-2",
"Factors":{"Sample source":"Mature seeds","Genotype":"Mutant"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-7",
"Sample ID":"52CR-1-3",
"Factors":{"Sample source":"Mature seeds","Genotype":"Mutant"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-8",
"Sample ID":"52CR-1-4",
"Factors":{"Sample source":"Mature seeds","Genotype":"Mutant"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-9",
"Sample ID":"52CR-2-1",
"Factors":{"Sample source":"Mature seeds","Genotype":"Mutant"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-10",
"Sample ID":"52CR-2-2",
"Factors":{"Sample source":"Mature seeds","Genotype":"Mutant"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-11",
"Sample ID":"52CR-2-3",
"Factors":{"Sample source":"Mature seeds","Genotype":"Mutant"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-12",
"Sample ID":"52CR-2-4",
"Factors":{"Sample source":"Mature seeds","Genotype":"Mutant"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-13",
"Sample ID":"52OE-1-1",
"Factors":{"Sample source":"Mature seeds","Genotype":"OE"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-14",
"Sample ID":"52OE-1-2",
"Factors":{"Sample source":"Mature seeds","Genotype":"OE"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-15",
"Sample ID":"52OE-1-3",
"Factors":{"Sample source":"Mature seeds","Genotype":"OE"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-16",
"Sample ID":"52OE-1-4",
"Factors":{"Sample source":"Mature seeds","Genotype":"OE"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-17",
"Sample ID":"52OE-2-1",
"Factors":{"Sample source":"Mature seeds","Genotype":"OE"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-18",
"Sample ID":"52OE-2-2",
"Factors":{"Sample source":"Mature seeds","Genotype":"OE"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
},
{
"Subject ID":"19-1-19",
"Sample ID":"52OE-2-3",
"Factors":{"Sample source":"Mature seeds","Genotype":"OE"},
"Additional sample data":{"RAW_FILE_NAME":"Data240621.WIFF"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"WT, OE and bnamyb52 mutant seeds were harvested in May 2024. The harvested seeds were stored at room temperature. The well-filled seeds were selected for metabolomic analysis. Mature seeds were ground into powder in liquid nitrogen, and 0.1 g of dry powder was weighed.","SAMPLE_TYPE":"Seeds"},

"TREATMENT":{"TREATMENT_SUMMARY":"WT,OE and Homozygous mutants were grown in the genetically modified field of Huazhong Agricultural University in Wuhan from October 2022 to May 2023 and from October 2023 to May 2024. WT indicates Wide-type. OE indicates BnaA09.MYB52 overexpression lines in the genetic background Westar. Mutant indicates four homologous genes of BnaMYB52 knocked out."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Mature seeds were ground into powder in liquid nitrogen, and 0.1 g of dry powder was weighed. The metabolites were extracted overnight under 4℃ with 1.0 mL 70% methanol (V/V) containing 0.1 mg/l acyclovir (an internal standard). After centrifugation at 10,000 g for 5 min, the supernatant was kept and filtered with a membrane (0.22 μm pore size).","PROCESSING_METHOD":"Grind in extraction solution","PROCESSING_STORAGE_CONDITIONS":"4℃","EXTRACTION_METHOD":"Extracted overnight under 4℃ with 1.0 mL 70% methanol (V/V) containing 0.1 mg/l acyclovir (an internal standard). After centrifugation at 10,000 g for 5 min, the supernatant was kept and filtered with a membrane","EXTRACT_STORAGE":"-80℃"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Shimadzu 20AD","COLUMN_NAME":"Waters ACQUITY UPLC HSS T3 (100 x 2.1mm,1.8um)","SOLVENT_A":"99.9% water/0.1% formic acid","SOLVENT_B":"99.9% acetonitrile/0.1% formic acid","FLOW_GRADIENT":"0-0.5min:5%B，0.5-7.5min:ramp to 95%B，7.5-9min:95%B，9-9.1 min：ramp to 5%B，9.1-10min:5%B","FLOW_RATE":"0.35mL/min","COLUMN_TEMPERATURE":"40"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"ABI Sciex 6500 QTrap","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"Acquisition parameters: A scheduled multiple reaction monitoring method was aplied based on comercial standards, with an MRM detection window of 90 s and a target scan time of 1.5 s. For those appeared within the MRM window and have similar MS2 fragments with designated standards, these metabolites that have different retention time are named as isomers. The acquisition volumn is 2 ul. Peak identification criteria: Compared with commercial standards，with retention time of ±0.2 min. Software used: Analyst 1.7.1 with default criteria."},

"MS_METABOLITE_DATA":{
"Units":"Peak area",

"Data":[{"Metabolite":"(-)-Epicatechin","WT-1":"27834.36407","WT-2":"25421.0744","WT-3":"28902.04767","WT-4":"30149.35778","52CR-1-1":"38722.32056","52CR-1-2":"36415.627","52CR-1-3":"37389.5168","52CR-1-4":"38229.01411","52CR-2-1":"23535.92808","52CR-2-2":"23989.04215","52CR-2-3":"25443.7373","52CR-2-4":"23014.43735","52OE-1-1":"41269.37665","52OE-1-2":"38573.40288","52OE-1-3":"51217.70364","52OE-1-4":"38070.36864","52OE-2-1":"33593.92311","52OE-2-2":"34812.35675","52OE-2-3":"31066.11391"},{"Metabolite":"(-)-Epicatechin isomer","WT-1":"68034.89196","WT-2":"67583.4634","WT-3":"61908.29037","WT-4":"75337.27442","52CR-1-1":"62488.31528","52CR-1-2":"66411.60482","52CR-1-3":"75609.336","52CR-1-4":"75747.09736","52CR-2-1":"61619.32405","52CR-2-2":"63952.09331","52CR-2-3":"76055.47768","52CR-2-4":"67908.3649","52OE-1-1":"68423.49674","52OE-1-2":"63226.24144","52OE-1-3":"73407.25456","52OE-1-4":"72802.34866","52OE-2-1":"80559.38778","52OE-2-2":"75499.09091","52OE-2-3":"84821.30136"},{"Metabolite":"(2S)-2''-Methoxykurarinone","WT-1":"606.0196588","WT-2":"296.3936222","WT-3":"86.62461575","WT-4":"649.6813959","52CR-1-1":"942.5787193","52CR-1-2":"164.5187631","52CR-1-3":"273.1714409","52CR-1-4":"278.4847625","52CR-2-1":"816.044483","52CR-2-2":"629.2188196","52CR-2-3":"1007.567044","52CR-2-4":"38.03226571","52OE-1-1":"456.3618011","52OE-1-2":"752.2261511","52OE-1-3":"47.04496362","52OE-1-4":"382.0002188","52OE-2-1":"1098.726759","52OE-2-2":"1085.603999","52OE-2-3":"343.2611901"},{"Metabolite":"(Neo)Amygdalin","WT-1":"17364.63137","WT-2":"23205.42804","WT-3":"10179.48637","WT-4":"13934.91109","52CR-1-1":"11098.22174","52CR-1-2":"9511.469402","52CR-1-3":"10579.35531","52CR-1-4":"11582.45778","52CR-2-1":"8358.703923","52CR-2-2":"14969.49205","52CR-2-3":"13149.50787","52CR-2-4":"9139.14126","52OE-1-1":"14530.64667","52OE-1-2":"14790.929","52OE-1-3":"5127.050146","52OE-1-4":"8826.980682","52OE-2-1":"7871.194324","52OE-2-2":"7303.676552","52OE-2-3":"5830.724411"},{"Metabolite":"(Rac)-Hydnocarpin","WT-1":"335.5728623","WT-2":"663.7940965","WT-3":"474.6407037","WT-4":"1102.152379","52CR-1-1":"882.5089957","52CR-1-2":"1236.337713","52CR-1-3":"535.0347712","52CR-1-4":"559.0928029","52CR-2-1":"402.5170248","52CR-2-2":"170.2639915","52CR-2-3":"1016.378896","52CR-2-4":"947.527539","52OE-1-1":"522.206522","52OE-1-2":"177.9814382","52OE-1-3":"266.7466486","52OE-1-4":"64.29782484","52OE-2-1":"738.0833934","52OE-2-2":"120.602974","52OE-2-3":"217.3671398"},{"Metabolite":"2-Methoxybenzoic acid","WT-1":"952814.1751","WT-2":"888038.5871","WT-3":"851244.2197","WT-4":"982470.3589","52CR-1-1":"849694.8265","52CR-1-2":"865772.1308","52CR-1-3":"850324.728","52CR-1-4":"835967.97","52CR-2-1":"725074.7201","52CR-2-2":"746271.8964","52CR-2-3":"768044.3005","52CR-2-4":"717756.0201","52OE-1-1":"1602475.56","52OE-1-2":"1720074.763","52OE-1-3":"1925095.347","52OE-1-4":"1554692.792","52OE-2-1":"2107516.055","52OE-2-2":"1675906.525","52OE-2-3":"1867765.539"},{"Metabolite":"3'',4''-Dihydroxyflavone","WT-1":"106.5833931","WT-2":"560.630173","WT-3":"763.7940701","WT-4":"362.7224383","52CR-1-1":"330.5351082","52CR-1-2":"156.1238658","52CR-1-3":"447.4513112","52CR-1-4":"379.9624472","52CR-2-1":"574.771131","52CR-2-2":"306.2631671","52CR-2-3":"217.390336","52CR-2-4":"877.0876605","52OE-1-1":"583.9797878","52OE-1-2":"912.5662286","52OE-1-3":"722.7312015","52OE-1-4":"170.2624696","52OE-2-1":"233.3671132","52OE-2-2":"518.6605012","52OE-2-3":"346.9204112"},{"Metabolite":"3-O-Ethyl-L-ascorbic acid","WT-1":"3605046.031","WT-2":"3775250.866","WT-3":"3126469.573","WT-4":"3145280.334","52CR-1-1":"3749261.996","52CR-1-2":"3516588.402","52CR-1-3":"3700404.477","52CR-1-4":"3402774.965","52CR-2-1":"3460250.013","52CR-2-2":"3400639.788","52CR-2-3":"3716512.39","52CR-2-4":"3675013.231","52OE-1-1":"3854630.879","52OE-1-2":"3395722.781","52OE-1-3":"3709717.683","52OE-1-4":"3763834.776","52OE-2-1":"3847007.876","52OE-2-2":"3509683.743","52OE-2-3":"3629076.55"},{"Metabolite":"3-O-Methylgalangin","WT-1":"3989.375236","WT-2":"14961.59665","WT-3":"3659.169458","WT-4":"9285.392404","52CR-1-1":"351.6199325","52CR-1-2":"4129.199616","52CR-1-3":"8490.455207","52CR-1-4":"8125.60175","52CR-2-1":"1233.538555","52CR-2-2":"705.0244974","52CR-2-3":"17431.98734","52CR-2-4":"3354.430802","52OE-1-1":"11310.68779","52OE-1-2":"4028.016927","52OE-1-3":"12691.92735","52OE-1-4":"5913.234551","52OE-2-1":"1749.94142","52OE-2-2":"4588.699262","52OE-2-3":"12823.98396"},{"Metabolite":"3-O-Methylquercetin","WT-1":"29809.57909","WT-2":"34005.89835","WT-3":"47093.55404","WT-4":"26654.93467","52CR-1-1":"35088.48086","52CR-1-2":"8856.558153","52CR-1-3":"30862.9492","52CR-1-4":"41566.0448","52CR-2-1":"35698.35181","52CR-2-2":"8092.393524","52CR-2-3":"38106.02183","52CR-2-4":"27184.28709","52OE-1-1":"6603.336897","52OE-1-2":"8519.416359","52OE-1-3":"25280.3786","52OE-1-4":"23284.06638","52OE-2-1":"32891.90654","52OE-2-2":"15802.31989","52OE-2-3":"18161.64035"},{"Metabolite":"4'',5-Dihydroxyflavone","WT-1":"939.2536253","WT-2":"2291.576958","WT-3":"4074.883132","WT-4":"3584.673984","52CR-1-1":"6624.815498","52CR-1-2":"563.3345599","52CR-1-3":"6289.772385","52CR-1-4":"931.3213146","52CR-2-1":"1244.223012","52CR-2-2":"4785.07439","52CR-2-3":"4159.102232","52CR-2-4":"1807.380036","52OE-1-1":"794.0345452","52OE-1-2":"4408.125336","52OE-1-3":"965.7412488","52OE-1-4":"3582.515084","52OE-2-1":"2522.641652","52OE-2-2":"4171.30824","52OE-2-3":"2004.033169"},{"Metabolite":"4''-Hydroxyflavanone","WT-1":"24.9565035","WT-2":"77.73809798","WT-3":"65.29404992","WT-4":"307.0827875","52CR-1-1":"186.0299133","52CR-1-2":"163.940435","52CR-1-3":"260.8853616","52CR-1-4":"100.1788862","52CR-2-1":"215.525143","52CR-2-2":"220.4845641","52CR-2-3":"215.4551904","52CR-2-4":"79.01989993","52OE-1-1":"32.83837819","52OE-1-2":"285.583566","52OE-1-3":"185.8264062","52OE-1-4":"149.0919697","52OE-2-1":"562.5016724","52OE-2-2":"268.265831","52OE-2-3":"577.9607396"},{"Metabolite":"4''-Methylchrysoeriol","WT-1":"12852.29472","WT-2":"9446.59963","WT-3":"7396.933022","WT-4":"14931.65116","52CR-1-1":"19339.09554","52CR-1-2":"17927.64054","52CR-1-3":"15093.5381","52CR-1-4":"10160.0362","52CR-2-1":"14266.64066","52CR-2-2":"8844.12112","52CR-2-3":"16896.41333","52CR-2-4":"17979.02454","52OE-1-1":"26314.66243","52OE-1-2":"28348.60523","52OE-1-3":"36207.86941","52OE-1-4":"20405.28857","52OE-2-1":"20006.91654","52OE-2-2":"26580.45035","52OE-2-3":"27694.50001"},{"Metabolite":"4-Pyridoxic acid","WT-1":"912335.2749","WT-2":"895321.0308","WT-3":"939306.4533","WT-4":"879100.3876","52CR-1-1":"926134.1388","52CR-1-2":"1051773.814","52CR-1-3":"911236.2222","52CR-1-4":"889724.2578","52CR-2-1":"774012.1766","52CR-2-2":"854448.2334","52CR-2-3":"806665.5063","52CR-2-4":"789389.1839","52OE-1-1":"1463344.878","52OE-1-2":"1270705.085","52OE-1-3":"1348230.883","52OE-1-4":"1347841.869","52OE-2-1":"1262744.307","52OE-2-2":"1393735.536","52OE-2-3":"1433272.852"},{"Metabolite":"5,7,3''-Trihydroxy-6,4'',5''-trimethoxyflavone","WT-1":"534.8770558","WT-2":"165.3522932","WT-3":"1079.730937","WT-4":"29.75098988","52CR-1-1":"616.7578067","52CR-1-2":"153.6193652","52CR-1-3":"1309.609859","52CR-1-4":"550.963571","52CR-2-1":"184.1566556","52CR-2-2":"35.34388851","52CR-2-3":"735.7622133","52CR-2-4":"566.1277662","52OE-1-1":"161.9545146","52OE-1-2":"78.800056","52OE-1-3":"946.4641391","52OE-1-4":"1415.267161","52OE-2-1":"54.05867394","52OE-2-2":"365.4898729","52OE-2-3":"160.5103508"},{"Metabolite":"5,7,3'',4''-Tetramethoxyflavone","WT-1":"76540.22007","WT-2":"77526.70446","WT-3":"72076.49141","WT-4":"78210.41006","52CR-1-1":"69739.92691","52CR-1-2":"75974.33106","52CR-1-3":"72734.8994","52CR-1-4":"76185.4592","52CR-2-1":"77223.56225","52CR-2-2":"75213.22502","52CR-2-3":"74507.5653","52CR-2-4":"91591.31608","52OE-1-1":"81672.2892","52OE-1-2":"26146.64917","52OE-1-3":"74231.17597","52OE-1-4":"78944.42194","52OE-2-1":"74999.34641","52OE-2-2":"76144.24124","52OE-2-3":"76961.95112"},{"Metabolite":"5,7-Dimethoxyluteolin isoform1","WT-1":"269.5767381","WT-2":"357.4030183","WT-3":"92.88530665","WT-4":"475.2222903","52CR-1-1":"243.4896618","52CR-1-2":"39.60454885","52CR-1-3":"171.9473219","52CR-1-4":"171.8293388","52CR-2-1":"558.0348135","52CR-2-2":"365.7577942","52CR-2-3":"427.8399243","52CR-2-4":"150.1171664","52OE-1-1":"42.43653969","52OE-1-2":"334.4728123","52OE-1-3":"78.77055765","52OE-1-4":"329.8293142","52OE-2-1":"187.8457431","52OE-2-2":"377.0164288","52OE-2-3":"301.7429452"},{"Metabolite":"6-Hydroxynicotinic acid","WT-1":"578496.1798","WT-2":"498625.4087","WT-3":"579218.1803","WT-4":"539145.0192","52CR-1-1":"605309.5625","52CR-1-2":"613115.9533","52CR-1-3":"594985.4513","52CR-1-4":"549751.2832","52CR-2-1":"570672.5741","52CR-2-2":"530970.0983","52CR-2-3":"523389.4695","52CR-2-4":"535686.617","52OE-1-1":"577026.3913","52OE-1-2":"532425.8366","52OE-1-3":"509890.7537","52OE-1-4":"529871.8566","52OE-2-1":"573881.5356","52OE-2-2":"535772.7668","52OE-2-3":"548223.1719"},{"Metabolite":"7,3'',4''-Tri-O-methylluteolin","WT-1":"277.8756405","WT-2":"1553.216333","WT-3":"1490.813761","WT-4":"737.1158707","52CR-1-1":"382.7986981","52CR-1-2":"351.1733843","52CR-1-3":"1191.919735","52CR-1-4":"419.2141761","52CR-2-1":"1211.025744","52CR-2-2":"479.8687258","52CR-2-3":"1004.002562","52CR-2-4":"919.3795245","52OE-1-1":"1633.208797","52OE-1-2":"1901.176922","52OE-1-3":"1315.516646","52OE-1-4":"1679.525601","52OE-2-1":"684.7526581","52OE-2-2":"414.6104894","52OE-2-3":"728.668874"},{"Metabolite":"7-Hydroxyflavone 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"Metabolites":[{"metabolite_name":"(-)-Epicatechin"},{"metabolite_name":"(-)-Epicatechin isomer"},{"metabolite_name":"(2S)-2''-Methoxykurarinone"},{"metabolite_name":"(Neo)Amygdalin"},{"metabolite_name":"(Rac)-Hydnocarpin"},{"metabolite_name":"2-Methoxybenzoic acid"},{"metabolite_name":"3'',4''-Dihydroxyflavone"},{"metabolite_name":"3-O-Ethyl-L-ascorbic acid"},{"metabolite_name":"3-O-Methylgalangin"},{"metabolite_name":"3-O-Methylquercetin"},{"metabolite_name":"4'',5-Dihydroxyflavone"},{"metabolite_name":"4''-Hydroxyflavanone"},{"metabolite_name":"4''-Methylchrysoeriol"},{"metabolite_name":"4-Pyridoxic acid"},{"metabolite_name":"5,7,3''-Trihydroxy-6,4'',5''-trimethoxyflavone"},{"metabolite_name":"5,7,3'',4''-Tetramethoxyflavone"},{"metabolite_name":"5,7-Dimethoxyluteolin isoform1"},{"metabolite_name":"6-Hydroxynicotinic acid"},{"metabolite_name":"7,3'',4''-Tri-O-methylluteolin"},{"metabolite_name":"7-Hydroxyflavone isoform1"},{"metabolite_name":"7-Hydroxyflavone 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(176)"},{"metabolite_name":"DiosMetin 7-O-β-D-Glucuronide (176) isoform1"},{"metabolite_name":"DiosMetin 7-O-β-D-Glucuronide (176) isoform2"},{"metabolite_name":"DiosMetin 7-O-β-D-Glucuronide (176) isoform3"},{"metabolite_name":"Diosmetin-7-O-β-D-glucopyranoside isomer"},{"metabolite_name":"Diosmin (146+162)"},{"metabolite_name":"Diosmin (146+162) isomer1"},{"metabolite_name":"D-Pantothenic acid"},{"metabolite_name":"Eriodictyol"},{"metabolite_name":"Eriodictyol-7-O-glucoside isomer1"},{"metabolite_name":"Eriodictyol-7-O-glucoside isomer2"},{"metabolite_name":"Ethyl 3,4-dihydroxybenzoate"},{"metabolite_name":"Eupatilin"},{"metabolite_name":"Farrerol isomer1"},{"metabolite_name":"Ferulic acid"},{"metabolite_name":"Ferulic acid isomer1"},{"metabolite_name":"Folinic acid"},{"metabolite_name":"Genistin"},{"metabolite_name":"Glycol salicylate"},{"metabolite_name":"Grosvenorine (146+146+162)"},{"metabolite_name":"Hesperidin methylchalcone (146+162)"},{"metabolite_name":"Hexyl nicotinate"},{"metabolite_name":"Hispidulin"},{"metabolite_name":"Icariin (146+162) isomer1"},{"metabolite_name":"IKarisoside A (146)"},{"metabolite_name":"IKarisoside A (146) isomer1"},{"metabolite_name":"Iristectorigenin A"},{"metabolite_name":"Isoorientin"},{"metabolite_name":"Isoquercetin"},{"metabolite_name":"Isorhamnetin 3/7-O-glucoside (162) isoform2"},{"metabolite_name":"Isorhamnetin 3/7-O-glucoside (162) isoform3"},{"metabolite_name":"Isorhamnetin 3/7-O-glucoside (162) isoform4"},{"metabolite_name":"Isorhamnetin-3/7-O-glucoside isomer1"},{"metabolite_name":"Isorhamnetin-3/7-O-glucoside isomer2"},{"metabolite_name":"Isorhamnetin-3/7-O-glucoside isomer3"},{"metabolite_name":"Isorhamnetin-3-O-glucoside (162)"},{"metabolite_name":"Isorhoifolin (146)"},{"metabolite_name":"Isorhoifolin (146+162)"},{"metabolite_name":"Isosinensetin"},{"metabolite_name":"Isovitexin"},{"metabolite_name":"Kaempferol 3,7,4''-trimethyl ether isomer1"},{"metabolite_name":"Kaempferol 3-O-sophoroside (162+162) isomer1"},{"metabolite_name":"Kaempferol 3-O-sophoroside (162+162) isomer2"},{"metabolite_name":"Kaempferol 3-O-β-D-glucuronide (Scutellarin)"},{"metabolite_name":"Kaempferol-3/7-O-rhamnoside (146) isomer2"},{"metabolite_name":"Kaempferol-3/7-O-rhamnoside (146) isomer3"},{"metabolite_name":"Kaempferol-7-O-rhamnoside (146) isomer1"},{"metabolite_name":"Kurarinone"},{"metabolite_name":"Kushenol A"},{"metabolite_name":"Kushenol I"},{"metabolite_name":"Leachianone A"},{"metabolite_name":"Licoflavone B"},{"metabolite_name":"Linarin (146+162)"},{"metabolite_name":"Liquiritigenin"},{"metabolite_name":"L-Phenylalanine"},{"metabolite_name":"Luteolin 7-O-glucuronide (176)"},{"metabolite_name":"Luteolin-7-rutinoside (146+162) isomer1"},{"metabolite_name":"Methyl paraben"},{"metabolite_name":"Methyl paraben isomer1"},{"metabolite_name":"Methylophiopogonanone A"},{"metabolite_name":"Methylophiopogonanone B"},{"metabolite_name":"Morusinol"},{"metabolite_name":"Naringenin"},{"metabolite_name":"Niacin"},{"metabolite_name":"Nicotinamide"},{"metabolite_name":"Nicotinamide ISOMER1"},{"metabolite_name":"Ombuin"},{"metabolite_name":"Ombuoside (146+162)"},{"metabolite_name":"Orotic acid"},{"metabolite_name":"Pantethine"},{"metabolite_name":"p-Coumaric acid"},{"metabolite_name":"Phloretin"},{"metabolite_name":"Phloretin isoform1"},{"metabolite_name":"Pinobanksin 3-acetate"},{"metabolite_name":"Pinocembrin-7-O-β-D-glucopyranoside"},{"metabolite_name":"Pinocembrin-7-O-β-D-glucopyranoside isomer1"},{"metabolite_name":"Pinoresinol 4-O-β-D-glucopyranoside"},{"metabolite_name":"Pinoresinol Diglucoside (162+162)"},{"metabolite_name":"Poriol"},{"metabolite_name":"Procyanidin A2"},{"metabolite_name":"Procyanidin A2 isomer1"},{"metabolite_name":"Procyanidin A2 isomer2"},{"metabolite_name":"Procyanidin B2"},{"metabolite_name":"Prunin (162)"},{"metabolite_name":"Prunin (162) isomer1"},{"metabolite_name":"Prunin isomer1"},{"metabolite_name":"Prunin isomer2"},{"metabolite_name":"Prunin isomer3"},{"metabolite_name":"Puerarin isomer1"},{"metabolite_name":"Quercetin"},{"metabolite_name":"Quercetin 3-O-hexoside isomer2"},{"metabolite_name":"Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden (162+162+162) isomer1"},{"metabolite_name":"Quercetin-7-O-β-D-glucopyranoside (162) isomer2"},{"metabolite_name":"Retinoic acid"},{"metabolite_name":"Rhamnocitrin"},{"metabolite_name":"Riboflavin"},{"metabolite_name":"Rutin (146+162)"},{"metabolite_name":"Scutellarein"},{"metabolite_name":"Sinapaldehyde"},{"metabolite_name":"SL 0101-1"},{"metabolite_name":"Sophoraflavanone G"},{"metabolite_name":"Taxifolin 7-O-β-D-glucoside (162)"},{"metabolite_name":"Taxifolin 7-O-β-D-glucoside (162) isomer1"},{"metabolite_name":"Taxifolin 7-O-β-D-glucoside (162) isomer2"},{"metabolite_name":"Tectoridin isomer1"},{"metabolite_name":"Tectoridin isomer2"},{"metabolite_name":"Thiamine"},{"metabolite_name":"Vitamin K4"},{"metabolite_name":"Vitexin-2-O-rhamnoside (146)"},{"metabolite_name":"β-Naphthoflavone"}]
}

}