{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000193","ANALYSIS_ID":"AN000295","VERSION":"1","CREATED_ON":"2016-09-17"},

"PROJECT":{"PROJECT_TITLE":"BAF60a LKO Liver specific knockout Bile acid","PROJECT_SUMMARY":"Regulation of Bile acid metabolism by hepatic BAF60a","INSTITUTE":"University of Michigan","DEPARTMENT":"Life Sciences Institute","LABORATORY":"Lin Lab","LAST_NAME":"Lin","FIRST_NAME":"Jiandie","ADDRESS":"Ann Arbor, MI","EMAIL":"jdlin@umich.edu","PHONE":"734-615-3512"},

"STUDY":{"STUDY_TITLE":"BAF60a LKO Liver specific knockout Bile acid","STUDY_TYPE":"Twelve weeks old WT and BAF60a Liver specfific knockout mice were fed with high diet for 8 weeks. Mice were sacrified after 4 h of starvation. Blood samples harvested by heart puncture for plasma. Liver were dissected and immediately in liquid nitrogen. All the samples were kept in -80oC freezer for long term","STUDY_SUMMARY":"Twelve weeks old WT and BAF60a Liver specfific knockout mice were fed with high diet for 8 weeks. Mice were sacrified after 4 h of starvation. Blood samples harvested by heart puncture for plasma. Liver were dissected and immediately in liquid nitrogen. All the samples were kept in -80oC freezer for long term","INSTITUTE":"University of Michigan","DEPARTMENT":"Biomedical Research Core Facilities","LABORATORY":"Metabolomics core","LAST_NAME":"Kachman","FIRST_NAME":"Maureen","ADDRESS":"6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714","EMAIL":"mkachman@umich.edu","PHONE":"-","NUM_GROUPS":"2","TOTAL_SUBJECTS":"18"},

"SUBJECT":{"SUBJECT_TYPE":"-","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"SU0003713",
"Sample ID":"S00014253",
"Factors":{"Genotype":"Knockout"}
},
{
"Subject ID":"SU0003718",
"Sample ID":"S00014258",
"Factors":{"Genotype":"Knockout"}
},
{
"Subject ID":"SU0003719",
"Sample ID":"S00014259",
"Factors":{"Genotype":"Knockout"}
},
{
"Subject ID":"SU0003721",
"Sample ID":"S00014261",
"Factors":{"Genotype":"Knockout"}
},
{
"Subject ID":"SU0003713",
"Sample ID":"S00014262",
"Factors":{"Genotype":"Knockout"}
},
{
"Subject ID":"SU0003718",
"Sample ID":"S00014267",
"Factors":{"Genotype":"Knockout"}
},
{
"Subject ID":"SU0003719",
"Sample ID":"S00014268",
"Factors":{"Genotype":"Knockout"}
},
{
"Subject ID":"SU0003721",
"Sample ID":"S00014270",
"Factors":{"Genotype":"Knockout"}
},
{
"Subject ID":"SU0003714",
"Sample ID":"S00014254",
"Factors":{"Genotype":"Wild type"}
},
{
"Subject ID":"SU0003715",
"Sample ID":"S00014255",
"Factors":{"Genotype":"Wild type"}
},
{
"Subject ID":"SU0003716",
"Sample ID":"S00014256",
"Factors":{"Genotype":"Wild type"}
},
{
"Subject ID":"SU0003717",
"Sample ID":"S00014257",
"Factors":{"Genotype":"Wild type"}
},
{
"Subject ID":"SU0003720",
"Sample ID":"S00014260",
"Factors":{"Genotype":"Wild type"}
},
{
"Subject ID":"SU0003714",
"Sample ID":"S00014263",
"Factors":{"Genotype":"Wild type"}
},
{
"Subject ID":"SU0003715",
"Sample ID":"S00014264",
"Factors":{"Genotype":"Wild type"}
},
{
"Subject ID":"SU0003716",
"Sample ID":"S00014265",
"Factors":{"Genotype":"Wild type"}
},
{
"Subject ID":"SU0003717",
"Sample ID":"S00014266",
"Factors":{"Genotype":"Wild type"}
},
{
"Subject ID":"SU0003720",
"Sample ID":"S00014269",
"Factors":{"Genotype":"Wild type"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"-","SAMPLE_TYPE":"Liver"},

"TREATMENT":{"TREATMENT_SUMMARY":"-"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"-","SAMPLEPREP_PROTOCOL_FILENAME":"Bile-acids-2015-03-11.docx"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"-","COLUMN_NAME":"Waters Acquity BEH C18 (50 x 2.1mm, 1.7um)","METHODS_ID":"AQM040","METHODS_FILENAME":"2014-03-27-Bile_acid-full-ESN-insert.m.zip"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","LABORATORY_NAME":"MRC2 (University of Michigan)","ACQUISITION_PARAMETERS_FILE":"2014-03-27-Bile_acid-full-ESN-insert.m.zip","PROCESSING_PARAMETERS_FILE":"EX00282-Bile-Acids-Quant-method.m.zip"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Agilent 6490 QQQ","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","ION_MODE":"NEGATIVE"},

"MS_METABOLITE_DATA":{
"Units":"nmol",

"Data":[{"Metabolite":"a-Muricholic acid","S00014253":"4.1789","S00014258":"","S00014259":"4.3054","S00014261":"3.1754","S00014262":"0.5348","S00014267":"23.0869","S00014268":"0.5703","S00014270":"4.3232","S00014254":"7.0726","S00014255":"12.1987","S00014256":"1.5295","S00014257":"1.6015","S00014260":"1.1870","S00014263":"0.3936","S00014264":"0.3231","S00014265":"0.8312","S00014266":"0.3083","S00014269":"0.1068"},{"Metabolite":"b-Muricholic acid","S00014253":"23.6882","S00014258":"438.3041","S00014259":"205.3238","S00014261":"37.6853","S00014262":"2.2432","S00014267":"228.2595","S00014268":"17.0742","S00014270":"21.4949","S00014254":"53.1749","S00014255":"96.7909","S00014256":"12.0752","S00014257":"16.1168","S00014260":"13.5265","S00014263":"4.2627","S00014264":"7.9110","S00014265":"9.6248","S00014266":"3.3978","S00014269":"3.2480"},{"Metabolite":"Chenodeoxycholic acid","S00014253":"8.1323","S00014258":"7.7241","S00014259":"25.1702","S00014261":"","S00014262":"0.2705","S00014267":"0.2562","S00014268":"0.2466","S00014270":"0.4360","S00014254":"9.9376","S00014255":"23.6225","S00014256":"0.8570","S00014257":"11.4653","S00014260":"","S00014263":"0.2378","S00014264":"0.2431","S00014265":"0.3710","S00014266":"0.2483","S00014269":"0.2968"},{"Metabolite":"Cholic acid","S00014253":"7.5341","S00014258":"188.5010","S00014259":"82.3430","S00014261":"10.2012","S00014262":"0.2961","S00014267":"467.4344","S00014268":"7.9031","S00014270":"34.3804","S00014254":"21.6475","S00014255":"79.4950","S00014256":"4.4171","S00014257":"21.9559","S00014260":"10.3629","S00014263":"0.2905","S00014264":"0.7482","S00014265":"0.4359","S00014266":"1.2383","S00014269":"0.5044"},{"Metabolite":"Deoxycholic acid","S00014253":"1.0221","S00014258":"53.9350","S00014259":"51.3462","S00014261":"57.6998","S00014262":"0.0078","S00014267":"0.0916","S00014268":"0.0306","S00014270":"0.1446","S00014254":"1.1508","S00014255":"12.7584","S00014256":"0.8756","S00014257":"7.1890","S00014260":"13.0157","S00014263":"0.0066","S00014264":"0.0194","S00014265":"0.0058","S00014266":"0.0105","S00014269":"0.0151"},{"Metabolite":"Glychocholic acid","S00014253":"1.6976","S00014258":"2.3255","S00014259":"1.3950","S00014261":"0.0984","S00014262":"0.2866","S00014267":"3.3656","S00014268":"0.5211","S00014270":"1.9494","S00014254":"0.6497","S00014255":"0.5871","S00014256":"0.0631","S00014257":"0.1999","S00014260":"0.1736","S00014263":"0.4694","S00014264":"0.3171","S00014265":"1.1522","S00014266":"0.5884","S00014269":"0.4692"},{"Metabolite":"Glycochenodeoxycholic acid","S00014253":"1.5577","S00014258":"1.0765","S00014259":"1.6516","S00014261":"1.7169","S00014262":"0.1233","S00014267":"0.2148","S00014268":"0.1348","S00014270":"0.2692","S00014254":"1.9557","S00014255":"1.4272","S00014256":"2.0088","S00014257":"1.7692","S00014260":"1.5663","S00014263":"0.1007","S00014264":"0.0827","S00014265":"0.1517","S00014266":"0.1098","S00014269":"0.0976"},{"Metabolite":"Glycodeoxycholic acid","S00014253":"0.1739","S00014258":"0.0834","S00014259":"0.1533","S00014261":"0.0695","S00014262":"","S00014267":"0.0958","S00014268":"0.0195","S00014270":"0.1927","S00014254":"","S00014255":"","S00014256":"","S00014257":"","S00014260":"0.1164","S00014263":"0.0024","S00014264":"0.0158","S00014265":"0.0034","S00014266":"0.0102","S00014269":"0.1059"},{"Metabolite":"GLYCO-HYODEOXYCHOLIC ACID/GLYCOURSODEOXYCHOLIC ACID","S00014253":"0.1482","S00014258":"0.0699","S00014259":"0.1116","S00014261":"0.0260","S00014262":"0.0496","S00014267":"0.1263","S00014268":"0.0406","S00014270":"0.1648","S00014254":"0.0861","S00014255":"0.0347","S00014256":"0.0305","S00014257":"0.0151","S00014260":"","S00014263":"0.0520","S00014264":"0.0266","S00014265":"0.0909","S00014266":"0.0169","S00014269":"0.0173"},{"Metabolite":"Glycolithocholic acid","S00014253":"","S00014258":"","S00014259":"","S00014261":"","S00014262":"","S00014267":"","S00014268":"","S00014270":"","S00014254":"","S00014255":"","S00014256":"","S00014257":"28.0672","S00014260":"","S00014263":"4.8878","S00014264":"","S00014265":"","S00014266":"","S00014269":""},{"Metabolite":"g-Muricholic acid (hyocholic acid)","S00014253":"","S00014258":"","S00014259":"","S00014261":"","S00014262":"0.1487","S00014267":"","S00014268":"","S00014270":"","S00014254":"","S00014255":"","S00014256":"","S00014257":"","S00014260":"","S00014263":"0.1157","S00014264":"0.2587","S00014265":"0.2175","S00014266":"4.4054","S00014269":"0.1051"},{"Metabolite":"Hyodeoxycholic acid","S00014253":"6.9453","S00014258":"72.8349","S00014259":"98.4861","S00014261":"26.7142","S00014262":"0.1438","S00014267":"1.0115","S00014268":"0.6639","S00014270":"0.9453","S00014254":"15.5307","S00014255":"50.0665","S00014256":"2.3639","S00014257":"14.9229","S00014260":"4.7512","S00014263":"0.3199","S00014264":"0.3108","S00014265":"0.3636","S00014266":"0.2650","S00014269":"0.1529"},{"Metabolite":"Lithocholic acid","S00014253":"3.8647","S00014258":"5.3238","S00014259":"4.4709","S00014261":"5.5767","S00014262":"","S00014267":"","S00014268":"","S00014270":"0.1186","S00014254":"4.5885","S00014255":"4.7778","S00014256":"4.3239","S00014257":"5.1130","S00014260":"3.4154","S00014263":"","S00014264":"","S00014265":"","S00014266":"0.0446","S00014269":""},{"Metabolite":"Taurochenodeoxycholic acid","S00014253":"12.2485","S00014258":"3.1990","S00014259":"9.7440","S00014261":"3.9331","S00014262":"10.8953","S00014267":"12.1795","S00014268":"10.2191","S00014270":"62.5498","S00014254":"3.1704","S00014255":"3.0545","S00014256":"5.1274","S00014257":"2.2880","S00014260":"3.5997","S00014263":"9.2642","S00014264":"8.0246","S00014265":"9.6491","S00014266":"9.0051","S00014269":"4.6705"},{"Metabolite":"Taurocholic acid","S00014253":"40.0657","S00014258":"18.0807","S00014259":"44.4774","S00014261":"10.5707","S00014262":"81.0582","S00014267":"408.4611","S00014268":"123.7122","S00014270":"410.3999","S00014254":"12.9477","S00014255":"250.2863","S00014256":"30.7240","S00014257":"12.2931","S00014260":"17.1861","S00014263":"77.3425","S00014264":"122.8872","S00014265":"125.6973","S00014266":"121.6505","S00014269":"89.7196"},{"Metabolite":"Taurodeoxycholic acid","S00014253":"13.5764","S00014258":"0.7674","S00014259":"0.7996","S00014261":"0.6414","S00014262":"1.7718","S00014267":"0.9648","S00014268":"11.2209","S00014270":"68.9097","S00014254":"3.4557","S00014255":"4.0120","S00014256":"6.7713","S00014257":"2.4884","S00014260":"3.9312","S00014263":"10.0582","S00014264":"8.7603","S00014265":"10.5946","S00014266":"5.2914","S00014269":"4.8132"},{"Metabolite":"Taurolithocolic acid","S00014253":"0.1941","S00014258":"0.3168","S00014259":"","S00014261":"","S00014262":"0.2043","S00014267":"0.6264","S00014268":"0.6744","S00014270":"2.3481","S00014254":"","S00014255":"0.2658","S00014256":"0.2246","S00014257":"","S00014260":"","S00014263":"0.2962","S00014264":"0.2800","S00014265":"0.2677","S00014266":"0.0237","S00014269":"0.3139"},{"Metabolite":"Tauroursodeoxycholic acid/Tauro-hyodeoxycholic acid","S00014253":"29.8597","S00014258":"7.8198","S00014259":"55.9587","S00014261":"16.4705","S00014262":"20.6261","S00014267":"38.1924","S00014268":"43.2647","S00014270":"131.0828","S00014254":"18.2386","S00014255":"44.3355","S00014256":"35.6690","S00014257":"20.6891","S00014260":"19.3819","S00014263":"22.8550","S00014264":"26.7984","S00014265":"30.3775","S00014266":"30.4527","S00014269":"13.8858"},{"Metabolite":"w-Muricholic acid","S00014253":"","S00014258":"","S00014259":"","S00014261":"","S00014262":"","S00014267":"103.1403","S00014268":"","S00014270":"","S00014254":"","S00014255":"","S00014256":"","S00014257":"","S00014260":"","S00014263":"","S00014264":"","S00014265":"","S00014266":"","S00014269":""}],

"Metabolites":[{"Metabolite":"a-Muricholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"53477700","inchi_key":"","kegg_id":"","other_id":"aMCA","other_id_type":"UM_Target_ID"},{"Metabolite":"b-Muricholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"5283853","inchi_key":"","kegg_id":"","other_id":"bMCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Chenodeoxycholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"10133","inchi_key":"","kegg_id":"","other_id":"CDCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Cholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"221493","inchi_key":"","kegg_id":"","other_id":"CA","other_id_type":"UM_Target_ID"},{"Metabolite":"Deoxycholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"6742","inchi_key":"","kegg_id":"","other_id":"DCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Glychocholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"10140","inchi_key":"","kegg_id":"","other_id":"GCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Glycochenodeoxycholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"9548796","inchi_key":"","kegg_id":"","other_id":"GCDCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Glycodeoxycholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"18602029","inchi_key":"","kegg_id":"","other_id":"GDCA","other_id_type":"UM_Target_ID"},{"Metabolite":"GLYCO-HYODEOXYCHOLIC ACID/GLYCOURSODEOXYCHOLIC ACID","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"12310288","inchi_key":"","kegg_id":"","other_id":"GHDCA/GUDCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Glycolithocholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"115245","inchi_key":"","kegg_id":"","other_id":"GLCA","other_id_type":"UM_Target_ID"},{"Metabolite":"g-Muricholic acid (hyocholic acid)","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"92805","inchi_key":"","kegg_id":"","other_id":"HCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Hyodeoxycholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"16219478","inchi_key":"","kegg_id":"","other_id":"HDCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Lithocholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"9903","inchi_key":"","kegg_id":"","other_id":"LCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Taurochenodeoxycholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"54608447","inchi_key":"","kegg_id":"","other_id":"TCDCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Taurocholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"6675","inchi_key":"","kegg_id":"","other_id":"TCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Taurodeoxycholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"10594","inchi_key":"","kegg_id":"","other_id":"TDCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Taurolithocolic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"10595","inchi_key":"","kegg_id":"","other_id":"TLCA","other_id_type":"UM_Target_ID"},{"Metabolite":"Tauroursodeoxycholic acid/Tauro-hyodeoxycholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"9848818","inchi_key":"","kegg_id":"","other_id":"THDCA/TUDCA","other_id_type":"UM_Target_ID"},{"Metabolite":"w-Muricholic acid","moverz_quant":"","ri":"","ri_type":"","pubchem_id":"5283851","inchi_key":"","kegg_id":"","other_id":"wMCA","other_id_type":"UM_Target_ID"}]
}

}