{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000307","ANALYSIS_ID":"AN000487","VERSION":"1","CREATED_ON":"January 4, 2016, 11:50 am"},

"PROJECT":{"PROJECT_TITLE":"CRBN's role in T cell activation","PROJECT_SUMMARY":"Targeting CRBN to alter CD8 T cell metabolism","INSTITUTE":"Moffitt Cancer Center","DEPARTMENT":"Immunology","LAST_NAME":"Burnette","FIRST_NAME":"Pearlie K.","ADDRESS":"-","EMAIL":"pearlie.burnette@moffitt.org","PHONE":"-"},

"STUDY":{"STUDY_TITLE":"Targeting CRBN to alter CD8 T cell metabolism","STUDY_TYPE":"T cell activation","STUDY_SUMMARY":"The purpose of this study was to evaluate the metabolic profile of different treatments of T-Cells among two separate mouse genotypes.","INSTITUTE":"University of Florida","DEPARTMENT":"SECIM","LABORATORY":"Moffitt Cancer Center - Immunology","LAST_NAME":"Swearingen","FIRST_NAME":"Rebecca","ADDRESS":"-","EMAIL":"rebecca.swearingen@moffitt.org","PHONE":"-","NUM_GROUPS":"12","TOTAL_SUBJECTS":"60"},

"SUBJECT":{"SUBJECT_TYPE":"Animal","SUBJECT_SPECIES":"Mus musculus","ANIMAL_ANIMAL_SUPPLIER":"WT (CRBN +/+) mice are from Jackson labs and CRBN -/- mice have been bred at Moffitt Cancer Center","ANIMAL_HOUSING":"Standard bedding + cotton pads, hepa filtered air","ANIMAL_LIGHT_CYCLE":"Dark 6pm-6am","ANIMAL_FEED":"Feed from Harlan, not sterile","ANIMAL_WATER":"autoclaved H2O","ANIMAL_INCLUSION_CRITERIA":"Animals used in this experiment were sex-matched and age matched. The ages were 8-12 weeks old in both sets of experiments"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"sbs_706",
"Sample ID":"CD3 + CD28 KO1 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_707",
"Sample ID":"CD3 + CD28 KO2 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_708",
"Sample ID":"CD3 + CD28 KO3 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_709",
"Sample ID":"CD3 + CD28 KO4 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_710",
"Sample ID":"CD3 + CD28 KO5 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_711",
"Sample ID":"CD3 KO1 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_712",
"Sample ID":"CD3 KO2 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_713",
"Sample ID":"CD3 KO3 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_714",
"Sample ID":"CD3 KO4 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_715",
"Sample ID":"CD3 KO5 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_716",
"Sample ID":"Naive KO1 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_717",
"Sample ID":"Naive KO2 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_718",
"Sample ID":"Naive KO3 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_719",
"Sample ID":"Naive KO4 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_720",
"Sample ID":"Naive KO5 042215",
"Factors":{"Strain":"CRBN -/-","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_721",
"Sample ID":"CD3 + CD28 WT1 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_722",
"Sample ID":"CD3 + CD28 WT2 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_723",
"Sample ID":"CD3 + CD28 WT3 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_724",
"Sample ID":"CD3 + CD28 WT4 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_725",
"Sample ID":"CD3 + CD28 WT5 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_726",
"Sample ID":"CD3 WT1 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_727",
"Sample ID":"CD3 WT2 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_728",
"Sample ID":"CD3 WT3 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_729",
"Sample ID":"CD3 WT4 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_730",
"Sample ID":"CD3 WT5 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_731",
"Sample ID":"Naive WT 1 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_732",
"Sample ID":"Naive WT 2 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_733",
"Sample ID":"Naive WT 3 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_734",
"Sample ID":"Naive WT 4 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_735",
"Sample ID":"Naive WT 5 042215",
"Factors":{"Strain":"CRBN +/+","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_736",
"Sample ID":"CD3 + CD28 KO1",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_737",
"Sample ID":"CD3 + CD28 KO2",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_738",
"Sample ID":"CD3 + CD28 KO3",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_739",
"Sample ID":"CD3 + CD28 KO4",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_740",
"Sample ID":"CD3 + CD28 KO5",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_741",
"Sample ID":"CD3 KO1",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_742",
"Sample ID":"CD3 KO2",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_743",
"Sample ID":"CD3 KO3",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_744",
"Sample ID":"CD3 KO4",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_745",
"Sample ID":"CD3 KO5",
"Factors":{"Strain":"CRBN -/-","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_746",
"Sample ID":"Naive KO1",
"Factors":{"Strain":"CRBN -/-","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_747",
"Sample ID":"Naive KO2",
"Factors":{"Strain":"CRBN -/-","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_748",
"Sample ID":"Naive KO3",
"Factors":{"Strain":"CRBN -/-","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_749",
"Sample ID":"Naive KO4",
"Factors":{"Strain":"CRBN -/-","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_750",
"Sample ID":"Naive KO5",
"Factors":{"Strain":"CRBN -/-","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_751",
"Sample ID":"CD3 + CD28 WT1",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_752",
"Sample ID":"CD3 + CD28 WT2",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_753",
"Sample ID":"CD3 + CD28 WT3",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_754",
"Sample ID":"CD3 + CD28 WT4",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_755",
"Sample ID":"CD3 + CD28 WT5",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 & anti-CD28 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_756",
"Sample ID":"CD3 WT1",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_757",
"Sample ID":"CD3 WT2",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_758",
"Sample ID":"CD3 WT3",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_759",
"Sample ID":"CD3 WT4",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_760",
"Sample ID":"CD3 WT5",
"Factors":{"Strain":"CRBN +/+","Treatment":"anti-CD3 stimulation"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_761",
"Sample ID":"Naive WT 1",
"Factors":{"Strain":"CRBN +/+","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_762",
"Sample ID":"Naive WT 2",
"Factors":{"Strain":"CRBN +/+","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_763",
"Sample ID":"Naive WT 3",
"Factors":{"Strain":"CRBN +/+","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_764",
"Sample ID":"Naive WT 4",
"Factors":{"Strain":"CRBN +/+","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
},
{
"Subject ID":"sbs_765",
"Sample ID":"Naive WT 5",
"Factors":{"Strain":"CRBN +/+","Treatment":"unstimulated"},
"Additional sample data":{"Gender":"M"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"-","SAMPLE_TYPE":"cell","COLLECTION_METHOD":"centrifuged in ficoll-gradient to remove debris, then washed in PBS","COLLECTION_TIME":"0 or 24 hours after stimulation","STORAGE_CONDITIONS":"-80°C","COLLECTION_VIALS":"15mL conical tubes","STORAGE_VIALS":"microfuge tubes"},

"TREATMENT":{"TREATMENT_SUMMARY":"-","ANIMAL_ANESTHESIA":"CO2 asphyxiation","ANIMAL_ACCLIMATION_DURATION":"Mice from Jackson are subjected to a week-long acclimation period in our facility prior to experimental use.","ANIMAL_ENDP_TISSUE_COLL_LIST":"Spleen into cell culture media","CELL_GROWTH_CONTAINER":"96-well round-bottom plate that was coated with anti-CD3 antibody","CELL_GROWTH_RATE":"Murine T cells generally divide after 48-72 hours of stimulation.","CELL_MEDIA":"RPMI 1640 with 10% FBS, pen/strep, gentamycin, NEAA, Sodium pyruvate, fungizone (Amphotericin B), 2-mercaptoethanol","CELL_ENVIR_COND":"37°C, normoxic conditions"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"-","SAMPLEPREP_PROTOCOL_FILENAME":"Consolidated Cellular Metabolomics with DNA quant.pdf","SAMPLE_SPIKING":"Appendix A - Internal Standard Prep GLCMS.pdf"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Thermo Scientific-Dionex Ultimate 3000","COLUMN_NAME":"ACE Excel 2 C18-PFP (100 x 2.1mm, 2um)","METHODS_FILENAME":"Metabolomics_LCMSProtocol.pdf"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","LABORATORY_NAME":"Garrett Lab","ANALYSIS_PROTOCOL_FILE":"Metabolomics_LCMSProtocol.pdf"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"NEGATIVE"},

"MS_METABOLITE_DATA":{
"Units":"Peak area",

"Data":[{"Metabolite":"(R)-MALATE","Naive WT 3":"8.99E+06","Naive KO3":"4.49E+06","Naive WT 2":"1.01E+07","Naive KO4":"5.21E+07","Naive KO2":"2.31E+07","Naive KO1":"8.24E+06","Naive KO5":"1.27E+08","Naive WT 1":"1.63E+08","Naive KO1 042215":"3.17E+06","Naive KO3 042215":"3.86E+06","Naive WT 5 042215":"3.24E+06","Naive WT 4 042215":"4.13E+06","Naive WT 4":"1.35E+07","Naive KO5 042215":"1.65E+06","Naive WT 2 042215":"4.03E+06","Naive KO2 042215":"3.44E+06","CD3 WT4":"5.26E+06","Naive WT 3 042215":"9.26E+06","Naive KO4 042215":"3.4E+06","CD3 WT1":"3.65E+07","CD3 KO2":"6.68E+06","CD3 KO1":"9.03E+06","Naive WT 1 042215":"7.72E+06","CD3 KO3":"9.14E+06","CD3 KO4 042215":"1.84E+06","CD3 KO2 042215":"4.36E+05","CD3 KO3 042215":"2.25E+06","CD3 KO1 042215":"3.03E+06","CD3 KO5 042215":"3.27E+06","CD3 KO4":"2.65E+07","CD3 KO5":"2.01E+07","CD3 WT2":"1.24E+08","CD3 WT2 042215":"4.22E+05","CD3 + CD28 KO1 042215":"1.53E+06","CD3 WT5 042215":"2.22E+06","CD3 WT4 042215":"4.14E+06","CD3 WT1 042215":"3.77E+06","CD3 WT3 042215":"1.19E+06","CD3 WT5":"1.66E+07","CD3 + CD28 KO5":"4.57E+06","CD3 + CD28 WT1 042215":"1.41E+06","CD3 + CD28 KO5 042215":"2.52E+06","CD3 + CD28 KO3 042215":"2.73E+06","CD3 + CD28 KO4 042215":"5.35E+06","CD3 + CD28 KO2 042215":"2.63E+06","CD3 + CD28 WT2":"3.7E+07","CD3 + CD28 WT1":"2.54E+08","Naive WT 5":"3.62E+08","CD3 + CD28 WT5 042215":"1.98E+06","CD3 + CD28 WT2 042215":"2.77E+06","CD3 + CD28 WT4 042215":"5.8E+06","CD3 + CD28 WT3 042215":"2.57E+06","CD3 + CD28 KO1":"1.39E+08","CD3 + CD28 WT4":"2.51E+08","CD3 + CD28 KO4":"2.39E+08","CD3 WT3":"4.73E+08","CD3 + CD28 WT3":"8.88E+07","CD3 + CD28 KO2":"3.63E+08","CD3 + CD28 KO3":"2.78E+08","CD3 + CD28 WT5":"5.4E+08"},{"Metabolite":"2',4'-DIHYDROXYACETOPHENONE","Naive WT 3":"8.56E+05","Naive KO3":"8.19E+05","Naive WT 2":"7.34E+05","Naive KO4":"7.6E+05","Naive KO2":"8.61E+05","Naive KO1":"9.8E+05","Naive KO5":"7.43E+05","Naive WT 1":"7.91E+05","Naive KO1 042215":"5.97E+05","Naive KO3 042215":"6.26E+05","Naive WT 5 042215":"6.28E+05","Naive WT 4 042215":"7.15E+05","Naive WT 4":"8.62E+05","Naive KO5 042215":"6.49E+05","Naive WT 2 042215":"7.62E+05","Naive KO2 042215":"5.96E+05","CD3 WT4":"8.31E+05","Naive WT 3 042215":"6.92E+05","Naive KO4 042215":"7.46E+05","CD3 WT1":"8.09E+05","CD3 KO2":"3.36E+06","CD3 KO1":"2.81E+06","Naive WT 1 042215":"7.35E+05","CD3 KO3":"2.86E+06","CD3 KO4 042215":"4.99E+05","CD3 KO2 042215":"6.69E+05","CD3 KO3 042215":"6.63E+05","CD3 KO1 042215":"6.59E+05","CD3 KO5 042215":"6.57E+05","CD3 KO4":"3.24E+06","CD3 KO5":"2.78E+06","CD3 WT2":"8.29E+05","CD3 WT2 042215":"7.49E+05","CD3 + CD28 KO1 042215":"9.54E+05","CD3 WT5 042215":"7.74E+05","CD3 WT4 042215":"7.2E+05","CD3 WT1 042215":"7.1E+05","CD3 WT3 042215":"6.56E+05","CD3 WT5":"7.75E+05","CD3 + CD28 KO5":"2.98E+06","CD3 + CD28 WT1 042215":"6.95E+05","CD3 + CD28 KO5 042215":"6.39E+05","CD3 + CD28 KO3 042215":"7.12E+05","CD3 + CD28 KO4 042215":"6.84E+05","CD3 + CD28 KO2 042215":"6.61E+05","CD3 + CD28 WT2":"9.01E+05","CD3 + CD28 WT1":"7.45E+05","Naive WT 5":"6.31E+06","CD3 + CD28 WT5 042215":"6.78E+05","CD3 + CD28 WT2 042215":"7.3E+05","CD3 + CD28 WT4 042215":"7.72E+05","CD3 + CD28 WT3 042215":"7.31E+05","CD3 + CD28 KO1":"2.79E+06","CD3 + CD28 WT4":"8.08E+05","CD3 + CD28 KO4":"2.2E+06","CD3 WT3":"1.05E+06","CD3 + CD28 WT3":"8.3E+05","CD3 + CD28 KO2":"2.58E+06","CD3 + CD28 KO3":"2.43E+06","CD3 + CD28 WT5":"8.38E+05"},{"Metabolite":"2-HYDROXYPHENYLACETIC ACID","Naive WT 3":"2.13E+05","Naive KO3":"1.92E+05","Naive WT 2":"1.68E+05","Naive KO4":"1.95E+05","Naive KO2":"1.95E+05","Naive KO1":"1.86E+05","Naive KO5":"2.4E+05","Naive WT 1":"2.36E+05","Naive KO1 042215":"1.17E+05","Naive KO3 042215":"1.09E+05","Naive WT 5 042215":"1.15E+05","Naive WT 4 042215":"1.26E+05","Naive WT 4":"1.96E+05","Naive KO5 042215":"1.1E+05","Naive WT 2 042215":"1.48E+05","Naive KO2 042215":"1.2E+05","CD3 WT4":"1.91E+05","Naive WT 3 042215":"1.3E+05","Naive KO4 042215":"1.32E+05","CD3 WT1":"1.81E+05","CD3 KO2":"1.71E+06","CD3 KO1":"1.49E+06","Naive WT 1 042215":"1.35E+05","CD3 KO3":"1.34E+06","CD3 KO4 042215":"9.41E+04","CD3 KO2 042215":"1.3E+05","CD3 KO3 042215":"1.23E+05","CD3 KO1 042215":"1.11E+05","CD3 KO5 042215":"1.26E+05","CD3 KO4":"1.48E+06","CD3 KO5":"1.36E+06","CD3 WT2":"2.49E+05","CD3 WT2 042215":"1.19E+05","CD3 + CD28 KO1 042215":"2.05E+05","CD3 WT5 042215":"1.41E+05","CD3 WT4 042215":"1.49E+05","CD3 WT1 042215":"1.61E+05","CD3 WT3 042215":"1.33E+05","CD3 WT5":"1.75E+05","CD3 + CD28 KO5":"1.23E+06","CD3 + CD28 WT1 042215":"1.23E+05","CD3 + CD28 KO5 042215":"1.16E+05","CD3 + CD28 KO3 042215":"1.44E+05","CD3 + CD28 KO4 042215":"1.38E+05","CD3 + CD28 KO2 042215":"1.3E+05","CD3 + CD28 WT2":"1.46E+05","CD3 + CD28 WT1":"3.43E+05","Naive WT 5":"1.84E+07","CD3 + CD28 WT5 042215":"1.34E+05","CD3 + CD28 WT2 042215":"1.39E+05","CD3 + CD28 WT4 042215":"1.95E+05","CD3 + CD28 WT3 042215":"1.49E+05","CD3 + CD28 KO1":"1.28E+06","CD3 + CD28 WT4":"2.87E+05","CD3 + CD28 KO4":"1.1E+06","CD3 WT3":"1.01E+06","CD3 + CD28 WT3":"6.25E+05","CD3 + CD28 KO2":"1.16E+06","CD3 + CD28 KO3":"1.06E+06","CD3 + CD28 WT5":"1.02E+06"},{"Metabolite":"3-(2-HYDROXYPHENYL)PROPANOATE","Naive WT 3":"1.08E+07","Naive KO3":"8.26E+05","Naive WT 2":"4.59E+05","Naive KO4":"2.01E+08","Naive KO2":"4.7E+07","Naive KO1":"1.17E+06","Naive KO5":"1.49E+07","Naive WT 1":"3.74E+05","Naive KO1 042215":"2E+05","Naive KO3 042215":"3.37E+05","Naive WT 5 042215":"3.31E+06","Naive WT 4 042215":"4.06E+05","Naive WT 4":"2.32E+05","Naive KO5 042215":"2.65E+05","Naive WT 2 042215":"1.54E+05","Naive KO2 042215":"7.56E+05","CD3 WT4":"2.82E+05","Naive WT 3 042215":"2.38E+07","Naive KO4 042215":"7.94E+06","CD3 WT1":"5.83E+05","CD3 KO2":"9.07E+06","CD3 KO1":"2.25E+06","Naive WT 1 042215":"3.03E+05","CD3 KO3":"7.65E+05","CD3 KO4 042215":"3.34E+05","CD3 KO2 042215":"6.24E+05","CD3 KO3 042215":"1.93E+05","CD3 KO1 042215":"3.72E+05","CD3 KO5 042215":"6.61E+05","CD3 KO4":"7.11E+07","CD3 KO5":"1.49E+08","CD3 WT2":"1.6E+07","CD3 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042215":"5.61E+05","CD3 + CD28 WT3 042215":"4.24E+05","CD3 + CD28 KO1":"4.61E+06","CD3 + CD28 WT4":"6.12E+05","CD3 + CD28 KO4":"1.11E+07","CD3 WT3":"5.65E+05","CD3 + CD28 WT3":"8.28E+05","CD3 + CD28 KO2":"1.6E+07","CD3 + CD28 KO3":"1.97E+07","CD3 + CD28 WT5":"4.86E+05"},{"Metabolite":"3-SULFINO-L-ALANINE","Naive WT 3":"7.04E+05","Naive KO3":"2.58E+04","Naive WT 2":"1.05E+06","Naive KO4":"6.94E+05","Naive KO2":"2.56E+06","Naive KO1":"9.88E+05","Naive KO5":"3.93E+06","Naive WT 1":"1.48E+06","Naive KO1 042215":"9.13E+03","Naive KO3 042215":"3.27E+04","Naive WT 5 042215":"1.04E+06","Naive WT 4 042215":"1.21E+05","Naive WT 4":"4.87E+06","Naive KO5 042215":"7.29E+03","Naive WT 2 042215":"1E+04","Naive KO2 042215":"2.51E+04","CD3 WT4":"1.46E+06","Naive WT 3 042215":"6.13E+04","Naive KO4 042215":"1.85E+04","CD3 WT1":"6.55E+06","CD3 KO2":"1.48E+05","CD3 KO1":"9.33E+05","Naive WT 1 042215":"8.8E+04","CD3 KO3":"2.57E+06","CD3 KO4 042215":"1.11E+04","CD3 KO2 042215":"8.9E+03","CD3 KO3 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CD28 KO3":"4.44E+03","CD3 + CD28 WT5":"650"},{"Metabolite":"URACIL","Naive WT 3":"5.39E+04","Naive KO3":"5.75E+04","Naive WT 2":"1.49E+04","Naive KO4":"2.26E+06","Naive KO2":"3.25E+05","Naive KO1":"3.54E+04","Naive KO5":"1.73E+05","Naive WT 1":"6.44E+04","Naive KO1 042215":"3.12E+05","Naive KO3 042215":"6.63E+04","Naive WT 5 042215":"2.12E+05","Naive WT 4 042215":"1.29E+06","Naive WT 4":"9.66E+04","Naive KO5 042215":"3.05E+04","Naive WT 2 042215":"1.74E+06","Naive KO2 042215":"8.51E+04","CD3 WT4":"9.95E+04","Naive WT 3 042215":"3.57E+05","Naive KO4 042215":"2.29E+05","CD3 WT1":"2.4E+05","CD3 KO2":"3.32E+04","CD3 KO1":"2.4E+05","Naive WT 1 042215":"5.28E+06","CD3 KO3":"1.09E+05","CD3 KO4 042215":"1.02E+04","CD3 KO2 042215":"3.24E+04","CD3 KO3 042215":"3.82E+04","CD3 KO1 042215":"6.46E+04","CD3 KO5 042215":"7.57E+04","CD3 KO4":"1.01E+06","CD3 KO5":"7.97E+05","CD3 WT2":"3.48E+05","CD3 WT2 042215":"1.11E+04","CD3 + CD28 KO1 042215":"4.38E+04","CD3 WT5 042215":"1.91E+04","CD3 WT4 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KO5":"2.12E+07","Naive WT 1":"1.68E+06","Naive KO1 042215":"2.25E+06","Naive KO3 042215":"1.18E+06","Naive WT 5 042215":"3.66E+06","Naive WT 4 042215":"5.41E+06","Naive WT 4":"1.57E+07","Naive KO5 042215":"1.57E+06","Naive WT 2 042215":"3.75E+07","Naive KO2 042215":"8.2E+05","CD3 WT4":"4.6E+06","Naive WT 3 042215":"3.12E+06","Naive KO4 042215":"1.14E+06","CD3 WT1":"2.18E+07","CD3 KO2":"2.02E+06","CD3 KO1":"1.18E+07","Naive WT 1 042215":"2.54E+08","CD3 KO3":"2.97E+06","CD3 KO4 042215":"6.57E+05","CD3 KO2 042215":"9.15E+05","CD3 KO3 042215":"9.1E+05","CD3 KO1 042215":"1.49E+06","CD3 KO5 042215":"1.5E+06","CD3 KO4":"6.6E+06","CD3 KO5":"8.08E+06","CD3 WT2":"3.98E+07","CD3 WT2 042215":"8.25E+05","CD3 + CD28 KO1 042215":"5.5E+05","CD3 WT5 042215":"7.3E+05","CD3 WT4 042215":"1.02E+06","CD3 WT1 042215":"1.7E+06","CD3 WT3 042215":"3.07E+05","CD3 WT5":"2.56E+06","CD3 + CD28 KO5":"9E+05","CD3 + CD28 WT1 042215":"3.48E+05","CD3 + CD28 KO5 042215":"6.59E+05","CD3 + CD28 KO3 042215":"5.91E+05","CD3 + CD28 KO4 042215":"1.13E+06","CD3 + CD28 KO2 042215":"5.19E+05","CD3 + CD28 WT2":"6.21E+07","CD3 + CD28 WT1":"9.3E+05","Naive WT 5":"6.28E+07","CD3 + CD28 WT5 042215":"7.55E+05","CD3 + CD28 WT2 042215":"8.62E+05","CD3 + CD28 WT4 042215":"1.85E+06","CD3 + CD28 WT3 042215":"1.07E+06","CD3 + CD28 KO1":"7.75E+06","CD3 + CD28 WT4":"2.22E+07","CD3 + CD28 KO4":"2.09E+07","CD3 WT3":"3.71E+06","CD3 + CD28 WT3":"4.28E+07","CD3 + CD28 KO2":"2.18E+07","CD3 + CD28 KO3":"2.42E+07","CD3 + CD28 WT5":"7.59E+06"}],

"Metabolites":[{"Metabolite":"(R)-MALATE","Retention Index":"1.01","PubChem CID":"92824","quant_moverz":"133.0140"},{"Metabolite":"2',4'-DIHYDROXYACETOPHENONE","Retention Index":"9.44","PubChem CID":"6990","quant_moverz":"151.0397"},{"Metabolite":"2-HYDROXYPHENYLACETIC ACID","Retention Index":"7.76","PubChem CID":"11914","quant_moverz":"151.0398"},{"Metabolite":"3-(2-HYDROXYPHENYL)PROPANOATE","Retention Index":"8.73","PubChem CID":"873","quant_moverz":"165.0554"},{"Metabolite":"3-HYDROXYPHENYLACETATE","Retention Index":"7.64","PubChem CID":"12122","quant_moverz":"151.0398"},{"Metabolite":"3-METHYL-2-OXOVALERIC ACID","Retention Index":"6.71","PubChem CID":"47","quant_moverz":"129.0555"},{"Metabolite":"3-SULFINO-L-ALANINE","Retention Index":"0.82","PubChem CID":"1549098","quant_moverz":"152.0020"},{"Metabolite":"4-COUMARATE","Retention Index":"8.11","PubChem CID":"637542","quant_moverz":"163.0400"},{"Metabolite":"4-GUANIDINOBUTANOATE","Retention Index":"1.63","PubChem CID":"500","quant_moverz":"144.0777"},{"Metabolite":"4-METHYL-2-OXO-PENTANOIC ACID","Retention Index":"7.09","PubChem CID":"70","quant_moverz":"129.0556"},{"Metabolite":"4-PYRIDOXATE","Retention Index":"5.55","PubChem CID":"6723","quant_moverz":"182.0456"},{"Metabolite":"ADENINE","Retention Index":"1.53","PubChem CID":"190","quant_moverz":"134.0470"},{"Metabolite":"ALDOPENTOSE","Retention Index":"0.82","PubChem CID":"NOT Found in Database","quant_moverz":"149.0453"},{"Metabolite":"ALLANTOIN","Retention Index":"0.82","PubChem CID":"204","quant_moverz":"157.0364"},{"Metabolite":"ALPHA-HYDROXYISOBUTYRIC ACID","Retention Index":"2.24","PubChem CID":"11671","quant_moverz":"103.0396"},{"Metabolite":"AZELAIC ACID","Retention Index":"8.54","PubChem CID":"2266","quant_moverz":"187.0972"},{"Metabolite":"C12H22O11-DISACCHARIDE-(6C/6C; GLC-GLC/GLC-FRC/GAL-GLC)","Retention Index":"0.88","PubChem CID":"NOT Found in Database","quant_moverz":"341.1082"},{"Metabolite":"C6H12O6-HEXOSE/KETOSE/INOSITOL","Retention Index":"0.75","PubChem CID":"NOT Found in Database","quant_moverz":"179.0557"},{"Metabolite":"CITRAMALATE","Retention Index":"2.20","PubChem CID":"1081","quant_moverz":"147.0297"},{"Metabolite":"CREATINE","Retention Index":"0.91","PubChem CID":"586","quant_moverz":"130.0620"},{"Metabolite":"CYTIDINE","Retention Index":"1.66","PubChem CID":"6175","quant_moverz":"242.0778"},{"Metabolite":"Disaccharide (6C/6C)","Retention Index":"0.88","PubChem CID":"NOT Found in Database","quant_moverz":"377.0851"},{"Metabolite":"ETHYLMALONIC ACID","Retention Index":"6.06","PubChem CID":"11756","quant_moverz":"131.0347"},{"Metabolite":"GLUCONIC ACID","Retention Index":"0.72","PubChem CID":"10690","quant_moverz":"195.0506"},{"Metabolite":"GLUTARATE","Retention Index":"4.68","PubChem CID":"743","quant_moverz":"131.0347"},{"Metabolite":"GLYCERALDEHYDE/LACTATE","Retention Index":"1.20","PubChem CID":"NOT Found in Database","quant_moverz":"89.0236"},{"Metabolite":"GLYCOLATE","Retention Index":"0.86","PubChem CID":"757","quant_moverz":"75.0080"},{"Metabolite":"GUANINE","Retention Index":"1.55","PubChem CID":"764","quant_moverz":"150.0419"},{"Metabolite":"GUANOSINE 5'-MONOPHOSPHATE","Retention Index":"1.94","PubChem CID":"6804","quant_moverz":"362.0504"},{"Metabolite":"hexose alcohol","Retention Index":"0.73","PubChem CID":"NOT Found in Database","quant_moverz":"181.0715"},{"Metabolite":"HOMOVANILLATE","Retention Index":"7.48","PubChem CID":"1738","quant_moverz":"181.0504"},{"Metabolite":"HYPOXANTHINE","Retention Index":"2.08","PubChem CID":"790","quant_moverz":"135.0310"},{"Metabolite":"ISOCITRIC ACID","Retention Index":"1.18","PubChem CID":"1198","quant_moverz":"191.0195"},{"Metabolite":"L-GLUTAMINE","Retention Index":"0.74","PubChem CID":"5961","quant_moverz":"145.0615"},{"Metabolite":"L-METHIONINE","Retention Index":"1.41","PubChem CID":"6137","quant_moverz":"148.0436"},{"Metabolite":"L-PHENYLALANINE","Retention Index":"6.20","PubChem CID":"6140","quant_moverz":"164.0716"},{"Metabolite":"L-TYROSINE","Retention Index":"3.39","PubChem CID":"6057","quant_moverz":"180.0663"},{"Metabolite":"MALONIC ACID","Retention Index":"1.12","PubChem CID":"867","quant_moverz":"103.0033"},{"Metabolite":"MEVALOLACTONE","Retention Index":"2.42","PubChem CID":"10428","quant_moverz":"147.0661"},{"Metabolite":"N-ACETYL-DL-GLUTAMIC ACID","Retention Index":"2.20","PubChem CID":"185","quant_moverz":"188.0560"},{"Metabolite":"N-ACETYL-DL-SERINE","Retention Index":"1.09","PubChem CID":"352294","quant_moverz":"146.0456"},{"Metabolite":"N-ACETYLGLYCINE","Retention Index":"1.20","PubChem CID":"10972","quant_moverz":"116.0350"},{"Metabolite":"N-ACETYL-L-ASPARTIC ACID","Retention Index":"1.59","PubChem CID":"65065","quant_moverz":"174.0405"},{"Metabolite":"N-ACETYL-L-LEUCINE","Retention Index":"7.71","PubChem CID":"70912","quant_moverz":"172.0977"},{"Metabolite":"NICOTINATE","Retention Index":"1.42","PubChem CID":"938","quant_moverz":"122.0247"},{"Metabolite":"N-METHYL-D-ASPARTIC ACID","Retention Index":"0.83","PubChem CID":"22880","quant_moverz":"146.0456"},{"Metabolite":"O-ACETYL-L-SERINE","Retention Index":"0.93","PubChem CID":"99478","quant_moverz":"146.0456"},{"Metabolite":"Salicylic Acid-d4","Retention Index":"9.94","PubChem CID":"46782907","quant_moverz":"141.0493"},{"Metabolite":"SUCCINATE","Retention Index":"2.29","PubChem CID":"1110","quant_moverz":"117.0190"},{"Metabolite":"Succinic Acid-d4","Retention Index":"2.25","PubChem CID":"NOT Found in Database","quant_moverz":"121.0443"},{"Metabolite":"THREONINE/HOMOSERINE","Retention Index":"0.73","PubChem CID":"NOT Found in Database","quant_moverz":"118.0508"},{"Metabolite":"THYMIDINE 5'-MONOPHOSPHATE","Retention Index":"3.78","PubChem CID":"9700","quant_moverz":"321.0486"},{"Metabolite":"URACIL","Retention Index":"1.67","PubChem CID":"1174","quant_moverz":"111.0197"},{"Metabolite":"URATE","Retention Index":"1.89","PubChem CID":"1175","quant_moverz":"167.0207"},{"Metabolite":"URIDINE","Retention Index":"2.87","PubChem CID":"6029","quant_moverz":"243.0619"},{"Metabolite":"UROCANATE","Retention Index":"2.01","PubChem CID":"736715","quant_moverz":"137.0353"},{"Metabolite":"XANTHINE","Retention Index":"2.53","PubChem CID":"1188","quant_moverz":"151.0259"}]
}

}