{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000321","ANALYSIS_ID":"AN000511","VERSION":"1","CREATED_ON":"January 15, 2016, 12:53 pm"},

"PROJECT":{"PROJECT_TITLE":"Effects of LGG on current drinkers gut metabolism","PROJECT_SUMMARY":"This experiment tests the effects of alcoholism by examining the primary metabolites obtained from mouse stool. Stool was collected from 4 groups of mice with varying treatments. One group was not humanized, another was humanized from a healthy human, a third was humanized from a current drinker, and the final group was humanized from a current drinker but also given a treatment of LGG. Humanizations were done to create a model of human gut activity in the mice.","INSTITUTE":"University of California, Davis","DEPARTMENT":"Genome and Biomedical Sciences Facility","LABORATORY":"WCMC Metabolomics Core","LAST_NAME":"Fiehn","FIRST_NAME":"Oliver","ADDRESS":"1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616","EMAIL":"ofiehn@ucdavis.edu","PHONE":"(530) 754-8258","FUNDING_SOURCE":"U24DK097154"},

"STUDY":{"STUDY_TITLE":"Effects of LGG on current drinkers gut metabolism","STUDY_SUMMARY":"This experiment tests the effects of alcoholism by examining the primary metabolites obtained from mouse stool. Stool was collected from 4 groups of mice with varying treatments. One group was not humanized, another was humanized from a healthy human, a third was humanized from a current drinker, and the final group was humanized from a current drinker but also given a treatment of LGG. Humanizations were done to create a model of human gut activity in the mice.","INSTITUTE":"University of California, Davis","DEPARTMENT":"Genome and Biomedical Sciences Facility","LABORATORY":"WCMC Metabolomics Core","LAST_NAME":"Fiehn","FIRST_NAME":"Oliver","ADDRESS":"1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616","EMAIL":"ofiehn@ucdavis.edu","PHONE":"(530) 754-8258","NUM_GROUPS":"8","TOTAL_SUBJECTS":"56","STUDY_COMMENTS":"Andrew Burch"},

"SUBJECT":{"SUBJECT_TYPE":"Animal","SUBJECT_SPECIES":"Mus musculus"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"ACI1-CC",
"Factors":{"Treatment":"Alcoholic cirrhosis infusion"}
},
{
"Subject ID":"-",
"Sample ID":"ACI2-CC",
"Factors":{"Treatment":"Alcoholic cirrhosis infusion"}
},
{
"Subject ID":"-",
"Sample ID":"ACI3-CC",
"Factors":{"Treatment":"Alcoholic cirrhosis infusion"}
},
{
"Subject ID":"-",
"Sample ID":"ACI4-CC",
"Factors":{"Treatment":"Alcoholic cirrhosis infusion"}
},
{
"Subject ID":"-",
"Sample ID":"ACI5-CC",
"Factors":{"Treatment":"Alcoholic cirrhosis infusion"}
},
{
"Subject ID":"-",
"Sample ID":"ACI6-CC",
"Factors":{"Treatment":"Alcoholic cirrhosis infusion"}
},
{
"Subject ID":"-",
"Sample ID":"ACI7-CC",
"Factors":{"Treatment":"Alcoholic cirrhosis infusion"}
},
{
"Subject ID":"-",
"Sample ID":"ACI8-CC",
"Factors":{"Treatment":"Alcoholic cirrhosis infusion"}
},
{
"Subject ID":"-",
"Sample ID":"ACI9-CC",
"Factors":{"Treatment":"Alcoholic cirrhosis infusion"}
},
{
"Subject ID":"-",
"Sample ID":"LG1-CC",
"Factors":{"Treatment":"LGG Treated"}
},
{
"Subject ID":"-",
"Sample ID":"LG2-CC",
"Factors":{"Treatment":"LGG Treated"}
},
{
"Subject ID":"-",
"Sample ID":"LG3-CC",
"Factors":{"Treatment":"LGG Treated"}
},
{
"Subject ID":"-",
"Sample ID":"LG4-CC",
"Factors":{"Treatment":"LGG Treated"}
},
{
"Subject ID":"-",
"Sample ID":"LG5-CC",
"Factors":{"Treatment":"LGG Treated"}
},
{
"Subject ID":"-",
"Sample ID":"LG6-CC",
"Factors":{"Treatment":"LGG Treated"}
},
{
"Subject ID":"-",
"Sample ID":"LG7-CC",
"Factors":{"Treatment":"LGG Treated"}
},
{
"Subject ID":"-",
"Sample ID":"LG8-CC",
"Factors":{"Treatment":"LGG Treated"}
},
{
"Subject ID":"-",
"Sample ID":"LG9-CC",
"Factors":{"Treatment":"LGG Treated"}
},
{
"Subject ID":"-",
"Sample ID":"CR1-CC",
"Factors":{"Treatment":"Germ Free Control"}
},
{
"Subject ID":"-",
"Sample ID":"CR2-CC",
"Factors":{"Treatment":"Germ Free Control"}
},
{
"Subject ID":"-",
"Sample ID":"CR3-CC",
"Factors":{"Treatment":"Germ Free Control"}
},
{
"Subject ID":"-",
"Sample ID":"CR4-CC",
"Factors":{"Treatment":"Germ Free Control"}
},
{
"Subject ID":"-",
"Sample ID":"1 HIGF-1",
"Factors":{"Treatment":"Normal Human Infusion"}
},
{
"Subject ID":"-",
"Sample ID":"2 HIGF-2",
"Factors":{"Treatment":"Normal Human Infusion"}
},
{
"Subject ID":"-",
"Sample ID":"3 HIGF-3",
"Factors":{"Treatment":"Normal Human Infusion"}
},
{
"Subject ID":"-",
"Sample ID":"4 HIGF-4",
"Factors":{"Treatment":"Normal Human Infusion"}
},
{
"Subject ID":"-",
"Sample ID":"5 HIGF-5",
"Factors":{"Treatment":"Normal Human Infusion"}
},
{
"Subject ID":"-",
"Sample ID":"6 HIGF-6",
"Factors":{"Treatment":"Normal Human Infusion"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Cecal contents","COLLECTION_PROTOCOL_FILENAME":"StudyDesign-AvinashSrivastava-82514.pdf","SAMPLE_TYPE":"Stool"},

"TREATMENT":{"TREATMENT_SUMMARY":"4 treatments: 4 mice who are germ-free (CR1-CC through CR 4 CC) 6 mice who have been humanized with stool from a healthy human (harvested at 30 days) (HI1-LC through HI6-LC) 9 mice who have been humanized with stool from a current drinker(harvested at 30 days) (ACL1-CC through ACL-9-CC) and 9 mice who have been humanized with stool from a current drinker and then supplemented with LGG (harvested at 30 days with 15 days of LGG, LG1-CC through LG9-CC)","TREATMENT_PROTOCOL_FILENAME":"StudyDesign_JasBajaj_8414.pdf"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Preparation of extraction mix and material before experiment: 1. Switch on bath to pre-cool at –20°C (2°C validity temperature range) 2. Check pH of acetonitrile and isopropanol (pH7) using wetted pH paper 3. Make the extraction solution by missing acetonitrile, isopropanol and water in proportions 3 : 3 : 2 4. Rinse the extraction solution for 5 min with nitrogen. Make sure that the nitrogen line was flushed out of air before using it for degassing the extraction solvent solution Sample Preparation 1. Weigh 50 mg tissue sample in to a 25 ml conical polypropylene centrifuge tube. 2. Add 2.5mL extraction solvent to the tissue sample and homogenize for 45 seconds ensuring that sample resembles a powder. In between samples, clean the homogenizer in solutions of methanol, acetone, water, and the extraction solvent. 3. Centrifuge the samples at 2500 rpm. for 5 minutes. Aliquot 2 X 500µl supernatant, one for analysis and one for a backup sample. Store backup aliquot in the -20°C freezer. 4. Evaporate one 500µl aliquot of the sample in the Labconco Centrivap cold trap concentrator to complete dryness 5. The dried aliquot is then re-suspended with 500l 50% acetonitrile (degassed as given) 6. Centrifuge for 2 min at 14000 rcf using the centrifuge Eppendorf 5415. 7. Remove supernatant to a new Eppendorff tube. 8. Evaporate the supernatant to dryness in the the Labconco Centrivap cold trap concentrator. 9. Submit to derivatization.","SAMPLEPREP_PROTOCOL_FILENAME":"SOP Extraction of Mammalian Tissue Samples.pdf"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"UPLC","CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Unspecified","COLUMN_NAME":"Waters Acquity CSH C18 (100 x 2.1mm, 1.7um) 1.7um Pre-Column","FLOW_GRADIENT":"15% B to 99% B","FLOW_RATE":"0.6 mL/min","COLUMN_TEMPERATURE":"65 C","METHODS_FILENAME":"Data Dictionary Fiehn laboratory_CSH QTOF lipidomics_05-29-2014.pdf","SOLVENT_A":"60:40 Acetonitrile:Water +10mM Ammonium Formate +10mM Formic Acid","SOLVENT_B":"9:1 Isopropanol:Acetonitrile +10mM Ammonium Formate +10mM Formic Acid","COLUMN_PRESSURE":"450-850 bar","INTERNAL_STANDARD":"See data dictionary","RETENTION_TIME":"See data dictionary","SAMPLE_INJECTION":"1.67 uL","ANALYTICAL_TIME":"13 min","CAPILLARY_VOLTAGE":"3500","TIME_PROGRAM":"15 min","WEAK_WASH_SOLVENT_NAME":"Isopropanol","WEAK_WASH_VOLUME":"5 seconds","STRONG_WASH_SOLVENT_NAME":"Isopropanol","TARGET_SAMPLE_TEMPERATURE":"Autosampler temp 4 C","RANDOMIZATION_ORDER":"Excel"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","LABORATORY_NAME":"WCMC Metabolomics Core","DETECTOR_TYPE":"TOF MCP","SOFTWARE_VERSION":"MassHunter","DATA_FORMAT":".d"},

"MS":{"INSTRUMENT_NAME":"Agilent 6550 QTOF","INSTRUMENT_TYPE":"QTOF","MS_TYPE":"ESI","ION_MODE":"NEGATIVE","MS_COMMENTS":"Lipidomics runs are MS1 data; Identifications made from pooled MS/MS runs","CAPILLARY_VOLTAGE":"3500","COLLISION_GAS":"Nitrogen","DRY_GAS_FLOW":"8 l/min","DRY_GAS_TEMP":"325","FRAGMENT_VOLTAGE":"120","FRAGMENTATION_METHOD":"Auto MS/MS","ION_SOURCE_TEMPERATURE":"325","ION_SPRAY_VOLTAGE":"1000","IONIZATION":"Pos","PRECURSOR_TYPE":"Intact Molecule","REAGENT_GAS":"Nitrogen","SOURCE_TEMPERATURE":"325 C","DESOLVATION_GAS_FLOW":"11 l/min","DESOLVATION_TEMPERATURE":"350 C","NEBULIZER":"35 psig","OCTPOLE_VOLTAGE":"750","RESOLUTION_SETTING":"Extended Dynamic Range","SCAN_RANGE_MOVERZ":"60-1700 Da","SCANNING_CYCLE":"2 Hz","SCANNING_RANGE":"60-1700 Da","SKIMMER_VOLTAGE":"65"},

"MS_METABOLITE_DATA":{
"Units":"Peak height",

"Data":[{"Metabolite":"Ceramide (d32:1)","ACI1-CC":"16335","ACI2-CC":"12208","ACI3-CC":"13557","ACI4-CC":"16953","ACI5-CC":"13868","ACI6-CC":"15839","ACI7-CC":"9418","ACI8-CC":"19469","ACI9-CC":"10140","LG1-CC":"12114","LG2-CC":"15246","LG3-CC":"11348","LG4-CC":"16110","LG5-CC":"14707","LG6-CC":"14655","LG7-CC":"16309","LG8-CC":"15974","LG9-CC":"13983","CR1-CC":"3813","CR2-CC":"4216","CR3-CC":"3413","CR4-CC":"3071","1 HIGF-1":"","2 HIGF-2":"3197","3 HIGF-3":"","4 HIGF-4":"5918","5 HIGF-5":"4213","6 HIGF-6":"2877"},{"Metabolite":"Ceramide (d33:1)","ACI1-CC":"40225","ACI2-CC":"36540","ACI3-CC":"35257","ACI4-CC":"49580","ACI5-CC":"49496","ACI6-CC":"43311","ACI7-CC":"31112","ACI8-CC":"71803","ACI9-CC":"31422","LG1-CC":"42344","LG2-CC":"43229","LG3-CC":"31733","LG4-CC":"41693","LG5-CC":"57427","LG6-CC":"47698","LG7-CC":"57447","LG8-CC":"51990","LG9-CC":"38536","CR1-CC":"7456","CR2-CC":"9083","CR3-CC":"4788","CR4-CC":"7535","1 HIGF-1":"2607","2 HIGF-2":"12282","3 HIGF-3":"5141","4 HIGF-4":"21135","5 HIGF-5":"11863","6 HIGF-6":"10631"},{"Metabolite":"Ceramide (d34:0)","ACI1-CC":"181431","ACI2-CC":"120740","ACI3-CC":"88342","ACI4-CC":"147588","ACI5-CC":"172330","ACI6-CC":"166389","ACI7-CC":"115157","ACI8-CC":"245277","ACI9-CC":"121707","LG1-CC":"132251","LG2-CC":"164745","LG3-CC":"92470","LG4-CC":"96263","LG5-CC":"168721","LG6-CC":"213217","LG7-CC":"233703","LG8-CC":"178203","LG9-CC":"137070","CR1-CC":"11954","CR2-CC":"20135","CR3-CC":"10978","CR4-CC":"17189","1 HIGF-1":"7150","2 HIGF-2":"15502","3 HIGF-3":"9498","4 HIGF-4":"33549","5 HIGF-5":"17997","6 HIGF-6":"11013"},{"Metabolite":"Ceramide (d34:1)","ACI1-CC":"2601995","ACI2-CC":"1987255","ACI3-CC":"1713669","ACI4-CC":"2616070","ACI5-CC":"2450772","ACI6-CC":"2535621","ACI7-CC":"1664009","ACI8-CC":"3821751","ACI9-CC":"1577986","LG1-CC":"1815438","LG2-CC":"2706274","LG3-CC":"1764641","LG4-CC":"2019034","LG5-CC":"2612183","LG6-CC":"2560659","LG7-CC":"3071385","LG8-CC":"2674687","LG9-CC":"2021922","CR1-CC":"199128","CR2-CC":"331329","CR3-CC":"212447","CR4-CC":"281055","1 HIGF-1":"22808","2 HIGF-2":"297821","3 HIGF-3":"61360","4 HIGF-4":"604137","5 HIGF-5":"329299","6 HIGF-6":"160950"},{"Metabolite":"Ceramide (d34:2)_1","ACI1-CC":"11852","ACI2-CC":"14814","ACI3-CC":"12581","ACI4-CC":"15322","ACI5-CC":"13585","ACI6-CC":"17594","ACI7-CC":"11039","ACI8-CC":"14133","ACI9-CC":"13237","LG1-CC":"9651","LG2-CC":"16329","LG3-CC":"9992","LG4-CC":"12326","LG5-CC":"13326","LG6-CC":"13258","LG7-CC":"14794","LG8-CC":"17730","LG9-CC":"13105","CR1-CC":"11116","CR2-CC":"18324","CR3-CC":"8004","CR4-CC":"20849","1 HIGF-1":"3193","2 HIGF-2":"16452","3 HIGF-3":"5911","4 HIGF-4":"5542","5 HIGF-5":"19797","6 HIGF-6":"13586"},{"Metabolite":"Ceramide (d34:2)_2","ACI1-CC":"27107","ACI2-CC":"15353","ACI3-CC":"15696","ACI4-CC":"25552","ACI5-CC":"17970","ACI6-CC":"23729","ACI7-CC":"11309","ACI8-CC":"37248","ACI9-CC":"12064","LG1-CC":"17578","LG2-CC":"27026","LG3-CC":"18327","LG4-CC":"21408","LG5-CC":"29778","LG6-CC":"27897","LG7-CC":"36897","LG8-CC":"31781","LG9-CC":"20141","CR1-CC":"","CR2-CC":"","CR3-CC":"","CR4-CC":"","1 HIGF-1":"","2 HIGF-2":"2848","3 HIGF-3":"2978","4 HIGF-4":"8311","5 HIGF-5":"5092","6 HIGF-6":"5267"},{"Metabolite":"Ceramide (d36:1)","ACI1-CC":"83338","ACI2-CC":"73528","ACI3-CC":"51148","ACI4-CC":"90464","ACI5-CC":"93654","ACI6-CC":"94515","ACI7-CC":"49386","ACI8-CC":"144424","ACI9-CC":"64694","LG1-CC":"75511","LG2-CC":"87665","LG3-CC":"57870","LG4-CC":"72339","LG5-CC":"87707","LG6-CC":"88383","LG7-CC":"93294","LG8-CC":"101699","LG9-CC":"111797","CR1-CC":"18073","CR2-CC":"28089","CR3-CC":"14217","CR4-CC":"18644","1 HIGF-1":"3450","2 HIGF-2":"22534","3 HIGF-3":"7172","4 HIGF-4":"53899","5 HIGF-5":"24911","6 HIGF-6":"17014"},{"Metabolite":"Ceramide (d38:1)","ACI1-CC":"14991","ACI2-CC":"7420","ACI3-CC":"10397","ACI4-CC":"16415","ACI5-CC":"11921","ACI6-CC":"15924","ACI7-CC":"6702","ACI8-CC":"23262","ACI9-CC":"11308","LG1-CC":"10062","LG2-CC":"13493","LG3-CC":"10894","LG4-CC":"15140","LG5-CC":"15373","LG6-CC":"13382","LG7-CC":"13759","LG8-CC":"16384","LG9-CC":"14780","CR1-CC":"4444","CR2-CC":"5726","CR3-CC":"5536","CR4-CC":"3911","1 HIGF-1":"","2 HIGF-2":"3137","3 HIGF-3":"","4 HIGF-4":"15464","5 HIGF-5":"6379","6 HIGF-6":"2876"},{"Metabolite":"Ceramide (d40:0)_1","ACI1-CC":"24033","ACI2-CC":"20164","ACI3-CC":"14153","ACI4-CC":"19002","ACI5-CC":"21960","ACI6-CC":"22593","ACI7-CC":"18374","ACI8-CC":"21408","ACI9-CC":"24554","LG1-CC":"23787","LG2-CC":"26415","LG3-CC":"16325","LG4-CC":"13133","LG5-CC":"26583","LG6-CC":"26233","LG7-CC":"28565","LG8-CC":"24941","LG9-CC":"23950","CR1-CC":"7590","CR2-CC":"10282","CR3-CC":"","CR4-CC":"7317","1 HIGF-1":"","2 HIGF-2":"4787","3 HIGF-3":"2404","4 HIGF-4":"12778","5 HIGF-5":"8098","6 HIGF-6":"4746"},{"Metabolite":"Ceramide (d40:0)_2","ACI1-CC":"221814","ACI2-CC":"158931","ACI3-CC":"88888","ACI4-CC":"156606","ACI5-CC":"191705","ACI6-CC":"168366","ACI7-CC":"139673","ACI8-CC":"244293","ACI9-CC":"156538","LG1-CC":"175515","LG2-CC":"222955","LG3-CC":"159813","LG4-CC":"112605","LG5-CC":"235853","LG6-CC":"164914","LG7-CC":"207523","LG8-CC":"146020","LG9-CC":"115397","CR1-CC":"37771","CR2-CC":"53622","CR3-CC":"22843","CR4-CC":"45175","1 HIGF-1":"5277","2 HIGF-2":"52219","3 HIGF-3":"13254","4 HIGF-4":"119182","5 HIGF-5":"67632","6 HIGF-6":"30657"},{"Metabolite":"Ceramide (d40:1)","ACI1-CC":"18429","ACI2-CC":"16060","ACI3-CC":"12307","ACI4-CC":"21164","ACI5-CC":"17078","ACI6-CC":"23947","ACI7-CC":"16085","ACI8-CC":"28073","ACI9-CC":"16046","LG1-CC":"16102","LG2-CC":"23725","LG3-CC":"13395","LG4-CC":"16754","LG5-CC":"22460","LG6-CC":"19218","LG7-CC":"21858","LG8-CC":"20192","LG9-CC":"19398","CR1-CC":"14690","CR2-CC":"18042","CR3-CC":"11338","CR4-CC":"11166","1 HIGF-1":"","2 HIGF-2":"6544","3 HIGF-3":"3935","4 HIGF-4":"27286","5 HIGF-5":"13927","6 HIGF-6":"7835"},{"Metabolite":"Ceramide (d40:2)","ACI1-CC":"2127","ACI2-CC":"4069","ACI3-CC":"","ACI4-CC":"2085","ACI5-CC":"3754","ACI6-CC":"3113","ACI7-CC":"2265","ACI8-CC":"2862","ACI9-CC":"3765","LG1-CC":"","LG2-CC":"2184","LG3-CC":"2256","LG4-CC":"","LG5-CC":"2538","LG6-CC":"2247","LG7-CC":"3681","LG8-CC":"8454","LG9-CC":"9801","CR1-CC":"4136","CR2-CC":"5412","CR3-CC":"2730","CR4-CC":"2949","1 HIGF-1":"","2 HIGF-2":"","3 HIGF-3":"","4 HIGF-4":"5341","5 HIGF-5":"3927","6 HIGF-6":"2582"},{"Metabolite":"Ceramide (d41:1)","ACI1-CC":"9757","ACI2-CC":"9968","ACI3-CC":"6582","ACI4-CC":"10164","ACI5-CC":"10697","ACI6-CC":"11033","ACI7-CC":"11137","ACI8-CC":"12781","ACI9-CC":"10923","LG1-CC":"9873","LG2-CC":"13808","LG3-CC":"8768","LG4-CC":"9193","LG5-CC":"15035","LG6-CC":"12087","LG7-CC":"14943","LG8-CC":"12614","LG9-CC":"9407","CR1-CC":"12379","CR2-CC":"14627","CR3-CC":"5864","CR4-CC":"10975","1 HIGF-1":"","2 HIGF-2":"3535","3 HIGF-3":"2371","4 HIGF-4":"13533","5 HIGF-5":"6349","6 HIGF-6":"4779"},{"Metabolite":"Ceramide (d42:0)_1","ACI1-CC":"104000","ACI2-CC":"77876","ACI3-CC":"63700","ACI4-CC":"86556","ACI5-CC":"64983","ACI6-CC":"89097","ACI7-CC":"64601","ACI8-CC":"63467","ACI9-CC":"88839","LG1-CC":"68277","LG2-CC":"75997","LG3-CC":"53646","LG4-CC":"46054","LG5-CC":"77153","LG6-CC":"60605","LG7-CC":"93771","LG8-CC":"63321","LG9-CC":"48508","CR1-CC":"29977","CR2-CC":"41637","CR3-CC":"10004","CR4-CC":"23700","1 HIGF-1":"3905","2 HIGF-2":"12268","3 HIGF-3":"8098","4 HIGF-4":"33014","5 HIGF-5":"21202","6 HIGF-6":"17514"},{"Metabolite":"Ceramide (d42:0)_2","ACI1-CC":"52146","ACI2-CC":"30023","ACI3-CC":"15083","ACI4-CC":"31843","ACI5-CC":"34954","ACI6-CC":"28163","ACI7-CC":"23595","ACI8-CC":"59556","ACI9-CC":"27603","LG1-CC":"29091","LG2-CC":"39651","LG3-CC":"26525","LG4-CC":"20154","LG5-CC":"46532","LG6-CC":"26668","LG7-CC":"44955","LG8-CC":"25281","LG9-CC":"18481","CR1-CC":"8568","CR2-CC":"12997","CR3-CC":"5366","CR4-CC":"12860","1 HIGF-1":"","2 HIGF-2":"14343","3 HIGF-3":"2956","4 HIGF-4":"32633","5 HIGF-5":"17050","6 HIGF-6":"6969"},{"Metabolite":"Ceramide (d42:2)","ACI1-CC":"20154","ACI2-CC":"15347","ACI3-CC":"10810","ACI4-CC":"21229","ACI5-CC":"14072","ACI6-CC":"17840","ACI7-CC":"19105","ACI8-CC":"45349","ACI9-CC":"15729","LG1-CC":"12234","LG2-CC":"23133","LG3-CC":"12887","LG4-CC":"19994","LG5-CC":"18001","LG6-CC":"20024","LG7-CC":"23821","LG8-CC":"18188","LG9-CC":"17392","CR1-CC":"12171","CR2-CC":"17650","CR3-CC":"11757","CR4-CC":"10545","1 HIGF-1":"","2 HIGF-2":"5011","3 HIGF-3":"2909","4 HIGF-4":"31735","5 HIGF-5":"13493","6 HIGF-6":"5666"},{"Metabolite":"Ceramide (d43:1)","ACI1-CC":"15384","ACI2-CC":"24820","ACI3-CC":"16955","ACI4-CC":"22860","ACI5-CC":"21158","ACI6-CC":"21342","ACI7-CC":"19329","ACI8-CC":"14735","ACI9-CC":"28365","LG1-CC":"25616","LG2-CC":"29440","LG3-CC":"24064","LG4-CC":"22053","LG5-CC":"34811","LG6-CC":"27975","LG7-CC":"53121","LG8-CC":"40860","LG9-CC":"18461","CR1-CC":"40158","CR2-CC":"45014","CR3-CC":"5772","CR4-CC":"25385","1 HIGF-1":"","2 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