{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000349","ANALYSIS_ID":"AN000565","VERSION":"1","CREATED_ON":"February 22, 2016, 7:39 am"},

"PROJECT":{"PROJECT_TITLE":"Non targeted meatbolomic profiling of transgenic- humanized amylin producing rats","PROJECT_TYPE":"GC-MS non targeted qualitative analysis","PROJECT_SUMMARY":"Non targeted metabolomic analysis on samples from rats expressing human amylin.","INSTITUTE":"University of North Carolina","DEPARTMENT":"McAllister heart Institute, Department of Internal medicine","LABORATORY":"Multiple Centers","LAST_NAME":"Ilaiwy","FIRST_NAME":"Amro","ADDRESS":"111 Mason Farm road, Chapel Hill, North Carolina, 27599-7126, USA","EMAIL":"amroilaiwy@gmail.com, monte_willis@med.unc.edu","PHONE":"210-596-0171","FUNDING_SOURCE":"NIH, Fondation Leducq"},

"STUDY":{"STUDY_TITLE":"Metabolomic analysis on samples from rats expressing human amylin (hepatic tissue).","STUDY_SUMMARY":"Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo. The 37 amino acid hormone Amylin is co­secreted with insulin from ß cells in the pancreas. In pre­diabetic and obese humans, chronic amylin hypersecretion parallels the course of disease and is involved in the pathophysiology of beta cell destruction in the pancreas. Recent studies in rats with transgenic expression of beta cell amylin (HIP), we have discovered that human amylin is prone to misfolding and has proteotoxic effects in vivo, resulting in the induction of cell death paralleling the pathophysiology of neurodegenerative disease. These misfolded proteotoxic amylin proteins are found to migrate to both the brain and heart to induce both neurologic deficits and cardiac dysfunction. In the present study, we use non­targeted GC­MS metabolomics analysis to investigate the metabolic consequences of amyloidogenic and cytotoxic amylin oligomers and diabetes in HIP heart, brain, liver, and plasma compared to wild type controls at 1 year of age. We identified that HIP hearts had 45 significantly altered metabolites by t­test (p<0.05) compared to wildtype control hearts (0.1­34.3 fold different,N=8/group). Similarly, we identified 30 metabolites significantly different in the HIP brain by t­test (p<0.05) compared to wildtype control brains (0.2­25.2 fold different (N=~10/group). HIP livers had 58 metabolites significantly altered by t­test (p<0.05) compared to wildtype livers (0.01­99.4 fold different,N=~10/group. Pathway enrichment analysis identified a systemic alteration in protein biosynthesis in the heart and brain of HIP rats compared to wild type controls. Alterations in phenylalanine metabolism and aminoacyl­tRNA biosynthesis were specifically affected in heart and plasma. Tyrosine metabolism is affected across organs, including decreased tyrosine (heart), phenylalanine (heart, liver, brain), and increased fumarate (heart, liver, brain). Increased urea and urea cycle were identified in heart and liver. As protein degradation is a major up­regulator of the urea cycle in human rat diabetic models, these findings suggest a broader connection between amylin, diabetes, protein catabolism, and effects on the urea cycle, which may contribute to the increased morbidity and mortality in diabetics at a multi­system level beyond the effects on glucose metabolism.","INSTITUTE":"University of North Carolina","LABORATORY":"Multiple Centers","LAST_NAME":"Ilaiwy","FIRST_NAME":"Amro","ADDRESS":"111 Mason Farm road, Chapel Hill, North Carolina, 27599-7126, USA","EMAIL":"amroilaiwy@gmail.com, monte_willis@med.unc.edu","PHONE":"210-596-0171","STUDY_COMMENTS":"Hepatic tissue"},

"SUBJECT":{"SUBJECT_TYPE":"Animal","SUBJECT_SPECIES":"Rattus norvegicus"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"CTRL2",
"Factors":{"Genotype":"WT"}
},
{
"Subject ID":"-",
"Sample ID":"SD4",
"Factors":{"Genotype":"WT"}
},
{
"Subject ID":"-",
"Sample ID":"2RT33",
"Factors":{"Genotype":"WT"}
},
{
"Subject ID":"-",
"Sample ID":"3RT25",
"Factors":{"Genotype":"WT"}
},
{
"Subject ID":"-",
"Sample ID":"3RT30",
"Factors":{"Genotype":"WT"}
},
{
"Subject ID":"-",
"Sample ID":"SD1",
"Factors":{"Genotype":"WT"}
},
{
"Subject ID":"-",
"Sample ID":"SD2",
"Factors":{"Genotype":"WT"}
},
{
"Subject ID":"-",
"Sample ID":"2RT32",
"Factors":{"Genotype":"WT"}
},
{
"Subject ID":"-",
"Sample ID":"14",
"Factors":{"Genotype":"WT"}
},
{
"Subject ID":"-",
"Sample ID":"3RT39",
"Factors":{"Genotype":"WT"}
},
{
"Subject ID":"-",
"Sample ID":"33",
"Factors":{"Genotype":"HIP"}
},
{
"Subject ID":"-",
"Sample ID":"34",
"Factors":{"Genotype":"HIP"}
},
{
"Subject ID":"-",
"Sample ID":"48",
"Factors":{"Genotype":"HIP"}
},
{
"Subject ID":"-",
"Sample ID":"15",
"Factors":{"Genotype":"HIP"}
},
{
"Subject ID":"-",
"Sample ID":"46",
"Factors":{"Genotype":"HIP"}
},
{
"Subject ID":"-",
"Sample ID":"23",
"Factors":{"Genotype":"HIP"}
},
{
"Subject ID":"-",
"Sample ID":"18",
"Factors":{"Genotype":"HIP"}
},
{
"Subject ID":"-",
"Sample ID":"22",
"Factors":{"Genotype":"HIP"}
},
{
"Subject ID":"-",
"Sample ID":"10",
"Factors":{"Genotype":"HIP"}
},
{
"Subject ID":"-",
"Sample ID":"32",
"Factors":{"Genotype":"HIP"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Hepatic tissue was harvested amd then flash frozen in a liquid nitrogen cooled biopress"},

"TREATMENT":{"TREATMENT_SUMMARY":"Fraction of hepatic tissue weighed (25–50 mg wet weight), then the finely cut up tissue quickly added to fresh pre-made buffer (50 % acetyl-nitrile, 50 % water, 0.3% formic acid) at a standard concentration of 25 mg/475 mcl buffer then fully homogenized on ice for 10–25 s and placed on dry ice/stored at - 80C"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"The samples were crash deprotonized by methanol precipitation and spiked with D27-deuterated myristic acid (D27-C14:0) as an internal standard for retention-time locking and dried. The trimethylsilyl-D27-C14:0 standard retention time (RT) was set at 16.727 min. Reactive carbonyls were stabilized at 50C with methoxyamine hydrochloride in dry pyridine. Metabolites were made volatile with TMS groups using N-methyl-N-(trimethylsilyl) trifluoroacetamide or MSTFA with catalytic trimethylchlorosilane at 50C."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"GC/MS methods follow previous studies using a 6890 N GC connected to a 5975 Inert single quadrupole MS (Agilent Technologies, Santa Clara, CA) (Bonikos et al. 1975; Fiehn 2008; Kind et al. 2009). The two wall-coated, open-tubular GC columns connected in series are both from J&W/Agilent (part 122–5512), DB5-MS, 15 meters in length, 0.25 mm in diameter, with an 0.25-l m luminal film. Positive ions generated with conventional electron-ionization at 70 eV are scanned broadly from 600 to 50 m/z in the detector throughout the 45 min cycle time.","CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"Agilent 6890N","COLUMN_NAME":"Agilent DB5-MS (15m × 0.25mm, 0.25um)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Agilent 5975","INSTRUMENT_TYPE":"Single quadrupole","MS_TYPE":"EI","ION_MODE":"POSITIVE"},

"MS_METABOLITE_DATA":{
"Units":"Peak values (Log transformed)",

"Data":[{"Metabolite":"Decamethyltetrasiloxane","CTRL2":"14.05","SD4":"13.39","2RT33":"11.9","3RT25":"16.14","3RT30":"13.45","SD1":"14.09","SD2":"14.69","2RT32":"14.12","14":"14.48","3RT39":"14.17","33":"13.62","34":"13.78","48":"14.03","15":"13.59","46":"13.69","23":"13.95","18":"","22":"14.33","10":"13.67","32":"13.76"},{"Metabolite":"2-Hydroxypyridine","CTRL2":"15.35","SD4":"15.19","2RT33":"15.43","3RT25":"14.79","3RT30":"14.89","SD1":"15.14","SD2":"15.18","2RT32":"15.02","14":"15.23","3RT39":"15.45","33":"15.58","34":"14.93","48":"15.26","15":"15.22","46":"14.39","23":"15.11","18":"16.28","22":"14.96","10":"15.32","32":"15.19"},{"Metabolite":"Pyruvic acid","CTRL2":"14.68","SD4":"13.62","2RT33":"13.85","3RT25":"13.28","3RT30":"14.22","SD1":"14.28","SD2":"13.96","2RT32":"14.33","14":"14.71","3RT39":"14.53","33":"13.99","34":"","48":"","15":"14.03","46":"13.38","23":"12.08","18":"","22":"","10":"","32":""},{"Metabolite":"Phenol","CTRL2":"14.6","SD4":"14.28","2RT33":"14.38","3RT25":"14.64","3RT30":"14.21","SD1":"13.92","SD2":"13.27","2RT32":"14.02","14":"14.06","3RT39":"","33":"13.56","34":"","48":"","15":"13.83","46":"","23":"14.04","18":"","22":"","10":"","32":""},{"Metabolite":"Lactic acid","CTRL2":"24.11","SD4":"23.85","2RT33":"23.15","3RT25":"23.62","3RT30":"23.11","SD1":"23.78","SD2":"23.49","2RT32":"22.87","14":"23.88","3RT39":"24.08","33":"23.02","34":"22.67","48":"22.24","15":"23.73","46":"22.46","23":"22.22","18":"22.26","22":"22.68","10":"22.26","32":"23.04"},{"Metabolite":"C10 hydrocarbon","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"14.53","SD1":"14.6","SD2":"16.07","2RT32":"15.28","14":"","3RT39":"","33":"14.83","34":"15.08","48":"15.25","15":"","46":"","23":"16.72","18":"15.18","22":"15.85","10":"16.26","32":""},{"Metabolite":"Alanine","CTRL2":"20.45","SD4":"20.48","2RT33":"20.04","3RT25":"19.28","3RT30":"20.75","SD1":"20.54","SD2":"18.12","2RT32":"19.9","14":"21.38","3RT39":"20.97","33":"18.21","34":"19.51","48":"19.36","15":"20.73","46":"19.25","23":"19.29","18":"19.28","22":"18.48","10":"18.14","32":"19.83"},{"Metabolite":"C11 hydrocarbon","CTRL2":"14.43","SD4":"14.14","2RT33":"14.31","3RT25":"14.23","3RT30":"14.11","SD1":"14.64","SD2":"14.85","2RT32":"14.48","14":"","3RT39":"14.11","33":"14.6","34":"13.71","48":"14.63","15":"14.03","46":"14.59","23":"14.31","18":"14.23","22":"14.45","10":"14.32","32":"13.64"},{"Metabolite":"2-Hydroxybutyric acid","CTRL2":"15.49","SD4":"14.65","2RT33":"15.97","3RT25":"15.95","3RT30":"15.17","SD1":"15.28","SD2":"15.02","2RT32":"15.49","14":"14.53","3RT39":"15.14","33":"16.43","34":"16.9","48":"17.02","15":"17.64","46":"17.15","23":"17.99","18":"17.77","22":"16.32","10":"17.49","32":"16.36"},{"Metabolite":"beta-Hydroxybutyric acid","CTRL2":"18.89","SD4":"20.23","2RT33":"19.42","3RT25":"19.1","3RT30":"18.59","SD1":"18.89","SD2":"20.02","2RT32":"19.67","14":"19.7","3RT39":"19.37","33":"22.34","34":"21.21","48":"22.5","15":"20.03","46":"21.42","23":"22.65","18":"22.22","22":"21.75","10":"21.78","32":"20.87"},{"Metabolite":"2-Aminobutanoic acid","CTRL2":"","SD4":"12.02","2RT33":"13.55","3RT25":"12.66","3RT30":"12.3","SD1":"11.67","SD2":"","2RT32":"12.43","14":"","3RT39":"","33":"14.01","34":"12.81","48":"13.73","15":"14.84","46":"12.8","23":"14.51","18":"14.04","22":"13.8","10":"12.16","32":"12.94"},{"Metabolite":"O-Methylphosphate","CTRL2":"19.58","SD4":"20.18","2RT33":"20","3RT25":"19.58","3RT30":"19.95","SD1":"19.55","SD2":"20.04","2RT32":"20.15","14":"20.76","3RT39":"20.22","33":"19.75","34":"19.76","48":"20.25","15":"20.56","46":"20.08","23":"20.42","18":"19.93","22":"20.09","10":"19.99","32":"20.38"},{"Metabolite":"Malonic acid","CTRL2":"17.01","SD4":"17.01","2RT33":"17.47","3RT25":"17.81","3RT30":"16.8","SD1":"17.31","SD2":"17.61","2RT32":"16.7","14":"17.63","3RT39":"17.31","33":"16.91","34":"16.73","48":"17.82","15":"17.57","46":"17.11","23":"17.65","18":"16.88","22":"17.77","10":"17.02","32":"17.5"},{"Metabolite":"Valine","CTRL2":"17.93","SD4":"18.46","2RT33":"18.48","3RT25":"18.44","3RT30":"18.98","SD1":"19.15","SD2":"17.62","2RT32":"18.2","14":"19.08","3RT39":"18.98","33":"19.25","34":"19.33","48":"19.21","15":"19.33","46":"19.35","23":"19.77","18":"19.09","22":"18.68","10":"18.26","32":"18.94"},{"Metabolite":"C12 hydrocarbon","CTRL2":"13.46","SD4":"13.04","2RT33":"13.32","3RT25":"13.57","3RT30":"13.29","SD1":"12.82","SD2":"13.66","2RT32":"13.25","14":"13.27","3RT39":"13.43","33":"12.65","34":"","48":"","15":"13.39","46":"","23":"13.68","18":"12.88","22":"12.96","10":"13.62","32":""},{"Metabolite":"Urea","CTRL2":"22.78","SD4":"22.45","2RT33":"22.39","3RT25":"22.36","3RT30":"22.31","SD1":"22.78","SD2":"22.49","2RT32":"22.26","14":"22.84","3RT39":"22.88","33":"23.21","34":"23.7","48":"23.7","15":"24.26","46":"24.16","23":"23.66","18":"22.97","22":"23.82","10":"23.3","32":"23.95"},{"Metabolite":"Benzoic acid","CTRL2":"16.44","SD4":"16.26","2RT33":"16.51","3RT25":"16.65","3RT30":"16.65","SD1":"16.22","SD2":"16.36","2RT32":"16.75","14":"16.08","3RT39":"16.33","33":"16.31","34":"16.41","48":"16.36","15":"16.21","46":"16.28","23":"16.48","18":"16.53","22":"16.36","10":"16.24","32":"15.83"},{"Metabolite":"Ethanolamine","CTRL2":"17.9","SD4":"18.16","2RT33":"18.68","3RT25":"17.46","3RT30":"18.03","SD1":"17.71","SD2":"17.87","2RT32":"19.27","14":"18.72","3RT39":"18.68","33":"17.48","34":"16.14","48":"18.73","15":"17.27","46":"18.37","23":"19.06","18":"17.45","22":"16.69","10":"16.28","32":"18.27"},{"Metabolite":"Pipecolic acid","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"","34":"","48":"","15":"15.58","46":"15.22","23":"","18":"","22":"","10":"","32":"14.56"},{"Metabolite":"Phosphoric acid","CTRL2":"25.31","SD4":"25.81","2RT33":"25.69","3RT25":"25.51","3RT30":"25.57","SD1":"25.56","SD2":"25.79","2RT32":"25.52","14":"26.12","3RT39":"26.1","33":"25.03","34":"25.42","48":"25.81","15":"26.05","46":"25.8","23":"25.85","18":"25.51","22":"25.46","10":"25.44","32":"25.93"},{"Metabolite":"Glycerol","CTRL2":"20.31","SD4":"21.23","2RT33":"20.74","3RT25":"22.08","3RT30":"22.01","SD1":"20.86","SD2":"20.89","2RT32":"20.53","14":"22.15","3RT39":"22.03","33":"19.63","34":"20.86","48":"20.68","15":"22.42","46":"21.75","23":"22.32","18":"21.17","22":"20.59","10":"20.8","32":"21.39"},{"Metabolite":"C13 hydrocarbon","CTRL2":"15.12","SD4":"15.24","2RT33":"15.47","3RT25":"14.93","3RT30":"15.55","SD1":"15.62","SD2":"15.49","2RT32":"15.42","14":"15.31","3RT39":"15.11","33":"14.96","34":"14.77","48":"15.09","15":"15.11","46":"15.1","23":"15.63","18":"15.13","22":"15.43","10":"15.21","32":"15.11"},{"Metabolite":"Isoleucine/Leucine","CTRL2":"18.42","SD4":"17.81","2RT33":"18.19","3RT25":"","3RT30":"18.24","SD1":"18.27","SD2":"","2RT32":"19.12","14":"19.91","3RT39":"18.4","33":"18.21","34":"18.75","48":"19.03","15":"18.74","46":"18.67","23":"19.03","18":"18.69","22":"17.54","10":"18.03","32":"18.08"},{"Metabolite":"Proline","CTRL2":"16.75","SD4":"15.93","2RT33":"16.71","3RT25":"15.47","3RT30":"16.97","SD1":"16.45","SD2":"14.4","2RT32":"16.73","14":"16.74","3RT39":"17.15","33":"15.77","34":"16.64","48":"17.09","15":"17.03","46":"16.36","23":"17.63","18":"16.14","22":"15.54","10":"15.66","32":"16.25"},{"Metabolite":"Glycine","CTRL2":"21.95","SD4":"22.18","2RT33":"22.34","3RT25":"21.96","3RT30":"22.08","SD1":"21.95","SD2":"21.89","2RT32":"22.24","14":"22.5","3RT39":"22.43","33":"22.62","34":"22.75","48":"23.35","15":"23.08","46":"22.92","23":"23.49","18":"22.66","22":"22.47","10":"22.74","32":"23.27"},{"Metabolite":"Succinic acid","CTRL2":"18.83","SD4":"19.9","2RT33":"17.28","3RT25":"17.87","3RT30":"17.36","SD1":"18.48","SD2":"20.24","2RT32":"16.55","14":"18.56","3RT39":"18.92","33":"","34":"18.41","48":"19.04","15":"19.24","46":"19.18","23":"21.14","18":"18.52","22":"18.57","10":"19.77","32":"18.32"},{"Metabolite":"Glyceric acid","CTRL2":"15.03","SD4":"14.38","2RT33":"14.15","3RT25":"14.98","3RT30":"15.26","SD1":"14.71","SD2":"15.89","2RT32":"14.77","14":"15.84","3RT39":"16.44","33":"","34":"","48":"","15":"","46":"","23":"","18":"","22":"","10":"","32":""},{"Metabolite":"MSTFA artifact","CTRL2":"17.64","SD4":"17.84","2RT33":"17.44","3RT25":"17.35","3RT30":"17.75","SD1":"17.52","SD2":"18.23","2RT32":"17.57","14":"17.83","3RT39":"18.7","33":"16.49","34":"17.79","48":"17.77","15":"17.64","46":"17.51","23":"18.08","18":"18.15","22":"17.85","10":"18.27","32":"18.08"},{"Metabolite":"Uracil","CTRL2":"15.89","SD4":"17.12","2RT33":"16.71","3RT25":"14.73","3RT30":"16.92","SD1":"15.89","SD2":"17.01","2RT32":"16.93","14":"17.47","3RT39":"16.47","33":"16.7","34":"16.91","48":"17.36","15":"17.61","46":"17.22","23":"18.74","18":"17.97","22":"17.45","10":"17.35","32":"19.12"},{"Metabolite":"Fumaric acid","CTRL2":"18.74","SD4":"18.33","2RT33":"18.53","3RT25":"18.38","3RT30":"18.56","SD1":"18.29","SD2":"18.93","2RT32":"18.36","14":"19.7","3RT39":"18.85","33":"18.93","34":"19.63","48":"18.77","15":"20.05","46":"19.49","23":"19.42","18":"19.13","22":"19.18","10":"19.75","32":"19.72"},{"Metabolite":"Serine","CTRL2":"19.36","SD4":"19.46","2RT33":"20.02","3RT25":"19.03","3RT30":"20.16","SD1":"19.89","SD2":"18.85","2RT32":"20.22","14":"20.48","3RT39":"20.45","33":"17.75","34":"17.87","48":"18.63","15":"17.93","46":"17.97","23":"19.24","18":"18.42","22":"16.66","10":"17.62","32":"19.51"},{"Metabolite":"Nonanoic acid","CTRL2":"12.58","SD4":"","2RT33":"12.05","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"12.96","3RT39":"","33":"","34":"12.85","48":"12.91","15":"","46":"","23":"","18":"","22":"13.1","10":"","32":""},{"Metabolite":"Threonine","CTRL2":"19.42","SD4":"19.35","2RT33":"19.79","3RT25":"19.43","3RT30":"19.9","SD1":"20.04","SD2":"19.38","2RT32":"20.04","14":"20.39","3RT39":"20.38","33":"18.04","34":"18.02","48":"19.04","15":"18.62","46":"18.18","23":"19.09","18":"18.32","22":"17.49","10":"17.77","32":"19.58"},{"Metabolite":"Hydroquinone or Resorcinol","CTRL2":"10.57","SD4":"13.01","2RT33":"","3RT25":"","3RT30":"11.05","SD1":"","SD2":"13.16","2RT32":"","14":"","3RT39":"","33":"","34":"12.96","48":"","15":"14.82","46":"11.03","23":"12.96","18":"14.21","22":"14.08","10":"","32":"13.12"},{"Metabolite":"6-Methyluracil","CTRL2":"","SD4":"13.88","2RT33":"13.9","3RT25":"13.76","3RT30":"14.56","SD1":"13.97","SD2":"","2RT32":"15.28","14":"14.33","3RT39":"15.19","33":"","34":"","48":"","15":"14.59","46":"","23":"12.08","18":"14.04","22":"12.73","10":"","32":"13.32"},{"Metabolite":"Methionine","CTRL2":"14.72","SD4":"15.47","2RT33":"15.27","3RT25":"16.19","3RT30":"16.23","SD1":"16.04","SD2":"16.11","2RT32":"15.48","14":"16.66","3RT39":"","33":"","34":"15.72","48":"14.62","15":"15.72","46":"15.18","23":"15.66","18":"14.48","22":"13.93","10":"16.15","32":"15.3"},{"Metabolite":"Aspartic acid","CTRL2":"19.26","SD4":"18.93","2RT33":"19.29","3RT25":"19.68","3RT30":"20.03","SD1":"18.84","SD2":"18.98","2RT32":"19.49","14":"19.81","3RT39":"19.72","33":"19.26","34":"19.61","48":"19.49","15":"20.7","46":"19.99","23":"19.64","18":"19.18","22":"18.96","10":"19.41","32":"20.42"},{"Metabolite":"beta-Alanine","CTRL2":"18.1","SD4":"18.26","2RT33":"18.65","3RT25":"18.32","3RT30":"18.2","SD1":"18.22","SD2":"18.27","2RT32":"18.67","14":"19.02","3RT39":"18.89","33":"17.53","34":"17.92","48":"17.83","15":"19.11","46":"17.54","23":"18.55","18":"17.52","22":"17.71","10":"17.63","32":"18.19"},{"Metabolite":"Threose/erythrose","CTRL2":"","SD4":"13.76","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"14.05","2RT32":"","14":"","3RT39":"","33":"14.83","34":"14.22","48":"15.54","15":"","46":"15.67","23":"16.38","18":"15.62","22":"14.26","10":"14.35","32":"15.51"},{"Metabolite":"Aminomalonic acid","CTRL2":"18.69","SD4":"19.01","2RT33":"19.15","3RT25":"18.74","3RT30":"19.45","SD1":"18.69","SD2":"19.06","2RT32":"19.16","14":"19.45","3RT39":"19.73","33":"19.56","34":"19.89","48":"20.43","15":"20.07","46":"19.33","23":"20.35","18":"19.52","22":"19.22","10":"20","32":"20.18"},{"Metabolite":"Aspartic acid ???","CTRL2":"14.62","SD4":"","2RT33":"","3RT25":"14.88","3RT30":"14.91","SD1":"","SD2":"14.87","2RT32":"","14":"15.95","3RT39":"15.98","33":"14.38","34":"14.31","48":"","15":"","46":"15.01","23":"","18":"","22":"13.95","10":"","32":""},{"Metabolite":"Nicotinamide","CTRL2":"19.07","SD4":"19.14","2RT33":"19.08","3RT25":"19.44","3RT30":"19.21","SD1":"18.72","SD2":"18.77","2RT32":"19.7","14":"19.53","3RT39":"19.57","33":"18.94","34":"19.25","48":"19.28","15":"19.39","46":"19.44","23":"19.7","18":"19.11","22":"19.04","10":"19.2","32":"19.47"},{"Metabolite":"Malic acid","CTRL2":"21.97","SD4":"21.97","2RT33":"22.08","3RT25":"21.74","3RT30":"21.91","SD1":"21.61","SD2":"21.97","2RT32":"21.51","14":"22.83","3RT39":"22.27","33":"22.16","34":"22.61","48":"21.8","15":"23.38","46":"22.65","23":"22.4","18":"22.22","22":"22.12","10":"22.53","32":"22.56"},{"Metabolite":"C15 hydrocarbon","CTRL2":"15.74","SD4":"15.61","2RT33":"15.66","3RT25":"15.5","3RT30":"15.89","SD1":"15.74","SD2":"15.55","2RT32":"15.73","14":"15.64","3RT39":"15.9","33":"15.68","34":"15.8","48":"15.5","15":"15.81","46":"15.9","23":"15.96","18":"15.92","22":"15.93","10":"15.84","32":"15.8"},{"Metabolite":"Threitol/erythritol","CTRL2":"14.64","SD4":"15.07","2RT33":"13.66","3RT25":"","3RT30":"","SD1":"13.26","SD2":"14.5","2RT32":"","14":"16.02","3RT39":"14.45","33":"13.37","34":"13.63","48":"14.8","15":"14.97","46":"14.74","23":"","18":"","22":"14.19","10":"","32":"14.16"},{"Metabolite":"Salicylic acid","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"","34":"","48":"12.66","15":"12.49","46":"12.91","23":"12.05","18":"13.16","22":"","10":"11.4","32":""},{"Metabolite":"Glutamic acid","CTRL2":"21.97","SD4":"22.2","2RT33":"22.26","3RT25":"22.54","3RT30":"21.91","SD1":"22.03","SD2":"22.17","2RT32":"21.98","14":"21.89","3RT39":"22.12","33":"21.02","34":"21.5","48":"21.81","15":"21.53","46":"21.25","23":"22.06","18":"21.69","22":"21.65","10":"21.7","32":"22.49"},{"Metabolite":"Hydroxyprolines","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"14.17","SD1":"","SD2":"13.95","2RT32":"","14":"13.65","3RT39":"14.12","33":"15.18","34":"15.67","48":"15.07","15":"16.34","46":"15.28","23":"16.01","18":"15.06","22":"15.34","10":"15.26","32":"14.92"},{"Metabolite":"Erythronic acid","CTRL2":"","SD4":"13.65","2RT33":"","3RT25":"14.9","3RT30":"14.63","SD1":"13.16","SD2":"13.51","2RT32":"","14":"14.67","3RT39":"14.01","33":"13.93","34":"13.95","48":"14.42","15":"14.73","46":"13.35","23":"13.61","18":"13.23","22":"","10":"14.31","32":"14.09"},{"Metabolite":"Hexadecamethylheptasiloxane","CTRL2":"","SD4":"","2RT33":"13.5","3RT25":"13.16","3RT30":"12.01","SD1":"","SD2":"","2RT32":"12.84","14":"","3RT39":"","33":"","34":"","48":"","15":"","46":"","23":"","18":"","22":"","10":"","32":""},{"Metabolite":"7H-Purine/Phenylalanine","CTRL2":"16.16","SD4":"16.88","2RT33":"16.21","3RT25":"17.1","3RT30":"17.34","SD1":"17.03","SD2":"16.79","2RT32":"16.58","14":"17.56","3RT39":"17.2","33":"13.51","34":"14.52","48":"15.49","15":"15.94","46":"15.52","23":"15.63","18":"15.4","22":"14.2","10":"15.02","32":"16.13"},{"Metabolite":"Cysteine/Creatinine","CTRL2":"17.85","SD4":"17.1","2RT33":"18.1","3RT25":"17.55","3RT30":"17.48","SD1":"17.56","SD2":"17.48","2RT32":"17.42","14":"18.04","3RT39":"17.63","33":"17.59","34":"20.51","48":"19.71","15":"20.4","46":"18.81","23":"20.41","18":"17.98","22":"19.68","10":"19.38","32":"19.87"},{"Metabolite":"Threonic acid","CTRL2":"","SD4":"14.34","2RT33":"13.32","3RT25":"","3RT30":"","SD1":"12.76","SD2":"","2RT32":"13.65","14":"12.83","3RT39":"13","33":"13.82","34":"","48":"","15":"","46":"12.35","23":"","18":"13.14","22":"","10":"11.7","32":""},{"Metabolite":"2-Hydroxyglutaric acid","CTRL2":"","SD4":"14.89","2RT33":"15.26","3RT25":"14.77","3RT30":"15.21","SD1":"15.62","SD2":"15.11","2RT32":"15.46","14":"15.87","3RT39":"15.39","33":"","34":"","48":"","15":"","46":"","23":"","18":"","22":"","10":"","32":""},{"Metabolite":"6-Hydroxynicotinic acid","CTRL2":"","SD4":"14.83","2RT33":"12.9","3RT25":"","3RT30":"","SD1":"14.47","SD2":"14.85","2RT32":"","14":"13.83","3RT39":"13.28","33":"","34":"","48":"","15":"","46":"","23":"","18":"12.98","22":"","10":"","32":"13.14"},{"Metabolite":"Phosphoenolpyruvic acid","CTRL2":"18.21","SD4":"17.37","2RT33":"17.72","3RT25":"17.14","3RT30":"17.51","SD1":"17.65","SD2":"16.48","2RT32":"17.99","14":"17.14","3RT39":"18.49","33":"16.33","34":"13.16","48":"14.62","15":"17.2","46":"16.68","23":"14.21","18":"15.63","22":"14.03","10":"","32":"15.82"},{"Metabolite":"2-Hydroxybiphenyl","CTRL2":"18.93","SD4":"18.81","2RT33":"","3RT25":"","3RT30":"","SD1":"19.02","SD2":"19.27","2RT32":"18.76","14":"","3RT39":"","33":"","34":"","48":"19.59","15":"19.87","46":"17.51","23":"18.17","18":"18.7","22":"","10":"17.34","32":"19.92"},{"Metabolite":"Hypotaurine","CTRL2":"19.36","SD4":"18.26","2RT33":"18.85","3RT25":"20.3","3RT30":"19.16","SD1":"19.72","SD2":"18.93","2RT32":"18.78","14":"20.26","3RT39":"19.58","33":"16.35","34":"16.11","48":"17.1","15":"18.62","46":"18.28","23":"17.14","18":"16.91","22":"16.28","10":"16.18","32":"19.18"},{"Metabolite":"Phenylalanine","CTRL2":"18.44","SD4":"18.98","2RT33":"18.81","3RT25":"18.81","3RT30":"19.26","SD1":"19.16","SD2":"18.83","2RT32":"18.95","14":"19.53","3RT39":"18.99","33":"16.98","34":"17.53","48":"18.55","15":"17.97","46":"17.87","23":"18.36","18":"18.02","22":"17.15","10":"17.4","32":"18.33"},{"Metabolite":"5-Aminovaleric acid","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"14.17","34":"14.09","48":"13.84","15":"","46":"14.03","23":"14.6","18":"14.09","22":"13.14","10":"","32":""},{"Metabolite":"N-Acetylaspartic acid","CTRL2":"17.43","SD4":"16.38","2RT33":"15.13","3RT25":"15.68","3RT30":"15.83","SD1":"14.53","SD2":"15.23","2RT32":"15.16","14":"","3RT39":"13.47","33":"15.01","34":"15.39","48":"13.83","15":"15.7","46":"14.31","23":"14.78","18":"","22":"14.17","10":"","32":"16.32"},{"Metabolite":"trans,trans-Muconic acid","CTRL2":"15.1","SD4":"17.03","2RT33":"16.09","3RT25":"15.46","3RT30":"16.03","SD1":"16.49","SD2":"15.6","2RT32":"16.24","14":"17.22","3RT39":"16.27","33":"15.48","34":"","48":"","15":"","46":"15.92","23":"15.96","18":"13.29","22":"","10":"","32":""},{"Metabolite":"Pyrophosphate","CTRL2":"15.05","SD4":"16.15","2RT33":"16","3RT25":"15.86","3RT30":"15.87","SD1":"14.6","SD2":"14.73","2RT32":"15.13","14":"15.75","3RT39":"16.05","33":"14.97","34":"15.22","48":"15.78","15":"16.18","46":"15.79","23":"16.04","18":"16.15","22":"14.7","10":"14.03","32":"15.54"},{"Metabolite":"Taurine","CTRL2":"","SD4":"","2RT33":"","3RT25":"15.99","3RT30":"13.67","SD1":"18.66","SD2":"18.05","2RT32":"","14":"16.83","3RT39":"","33":"","34":"","48":"","15":"","46":"","23":"","18":"12.28","22":"","10":"","32":"15.05"},{"Metabolite":"Aldopentoses","CTRL2":"20.52","SD4":"21.95","2RT33":"21.35","3RT25":"20.94","3RT30":"21.37","SD1":"20.86","SD2":"21.55","2RT32":"21.28","14":"21.98","3RT39":"21.85","33":"22.22","34":"21.94","48":"22.68","15":"21.64","46":"22.72","23":"23.2","18":"22.39","22":"21.78","10":"22.17","32":"21.95"},{"Metabolite":"Cysteinesulfinic acid","CTRL2":"12.62","SD4":"","2RT33":"","3RT25":"","3RT30":"13.85","SD1":"","SD2":"","2RT32":"14.32","14":"","3RT39":"","33":"19.22","34":"18.89","48":"19.36","15":"19.35","46":"19.08","23":"19.21","18":"18.56","22":"18.36","10":"18.7","32":"18.29"},{"Metabolite":"Octadecamethyloctasiloxane","CTRL2":"14.46","SD4":"14.02","2RT33":"14.9","3RT25":"14.41","3RT30":"14.22","SD1":"14.04","SD2":"14.36","2RT32":"14.4","14":"13.76","3RT39":"14.66","33":"","34":"","48":"14.27","15":"15.08","46":"","23":"14.84","18":"14.17","22":"14.34","10":"14.06","32":""},{"Metabolite":"2-Aminoadipic acid","CTRL2":"19.52","SD4":"19.75","2RT33":"19.52","3RT25":"19.34","3RT30":"19.25","SD1":"18.91","SD2":"19.23","2RT32":"19.46","14":"18.73","3RT39":"19.47","33":"18.95","34":"14.3","48":"19.13","15":"17.48","46":"19.39","23":"19.13","18":"19.15","22":"19.09","10":"18.71","32":"18.82"},{"Metabolite":"N-Methylglutamic acid","CTRL2":"13.26","SD4":"","2RT33":"","3RT25":"13.81","3RT30":"","SD1":"","SD2":"","2RT32":"13.85","14":"","3RT39":"","33":"","34":"14.3","48":"14.43","15":"17.48","46":"","23":"13.33","18":"","22":"13.55","10":"","32":"14.03"},{"Metabolite":"Pentitols","CTRL2":"17.72","SD4":"18.59","2RT33":"18.02","3RT25":"18.12","3RT30":"18.3","SD1":"18.17","SD2":"18.37","2RT32":"17.58","14":"18.83","3RT39":"18.95","33":"18.53","34":"18.14","48":"18.14","15":"18.13","46":"18.95","23":"19.7","18":"18.23","22":"17.67","10":"17.71","32":"17.37"},{"Metabolite":"Glycerol 1-phosphate","CTRL2":"24.19","SD4":"23.75","2RT33":"24.49","3RT25":"25.24","3RT30":"24.78","SD1":"23.14","SD2":"23.69","2RT32":"24.57","14":"23.78","3RT39":"24.21","33":"22.6","34":"22.69","48":"23.76","15":"24.3","46":"23.32","23":"23.34","18":"22.1","22":"22.6","10":"22.5","32":"23.97"},{"Metabolite":"Glutamine","CTRL2":"20.74","SD4":"15.76","2RT33":"","3RT25":"","3RT30":"19.03","SD1":"","SD2":"","2RT32":"21.82","14":"15.79","3RT39":"18.24","33":"21.58","34":"22.14","48":"21.64","15":"18.45","46":"21.34","23":"19.7","18":"18.64","22":"21.63","10":"21.09","32":"20.76"},{"Metabolite":"2-Phosphoglyceric acid","CTRL2":"16.51","SD4":"15.17","2RT33":"","3RT25":"","3RT30":"","SD1":"15.54","SD2":"13.84","2RT32":"","14":"15.15","3RT39":"16.54","33":"14.27","34":"","48":"","15":"","46":"12.93","23":"","18":"","22":"","10":"","32":""},{"Metabolite":"Pentonic acids","CTRL2":"13.05","SD4":"","2RT33":"12.65","3RT25":"12.63","3RT30":"12.52","SD1":"","SD2":"","2RT32":"12.32","14":"12.7","3RT39":"13.46","33":"","34":"14.29","48":"13.59","15":"13.58","46":"13.22","23":"13.83","18":"12.77","22":"13.56","10":"12.96","32":"12.96"},{"Metabolite":"N-Acetylglutamic acid","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"14.99","34":"","48":"15.82","15":"17.36","46":"","23":"","18":"15.85","22":"","10":"","32":""},{"Metabolite":"O-Phosphocolamine","CTRL2":"18.69","SD4":"19.18","2RT33":"19.24","3RT25":"19.34","3RT30":"18.98","SD1":"18.79","SD2":"19.29","2RT32":"19.47","14":"19.44","3RT39":"19.86","33":"18.61","34":"18.7","48":"19.36","15":"20.65","46":"19.11","23":"19.6","18":"19.12","22":"19.34","10":"18.89","32":"21.29"},{"Metabolite":"Gentisic acid","CTRL2":"17.17","SD4":"16.98","2RT33":"17.69","3RT25":"17.14","3RT30":"","SD1":"16.69","SD2":"16.78","2RT32":"","14":"16.85","3RT39":"17.13","33":"15.97","34":"","48":"17","15":"17.24","46":"17.25","23":"17.33","18":"17.14","22":"16.69","10":"17.02","32":""},{"Metabolite":"Hypoxanthine","CTRL2":"19.84","SD4":"20.88","2RT33":"20.62","3RT25":"19.85","3RT30":"20.25","SD1":"20.94","SD2":"20.57","2RT32":"20.29","14":"21.84","3RT39":"20.79","33":"20.58","34":"20.98","48":"21.49","15":"20.48","46":"21.71","23":"21.64","18":"21.06","22":"20.66","10":"20.83","32":"20.87"},{"Metabolite":"Epinephrine","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"","34":"20.08","48":"17.82","15":"17.69","46":"","23":"","18":"","22":"","10":"","32":""},{"Metabolite":"Cysteinylglycine","CTRL2":"","SD4":"","2RT33":"","3RT25":"13.33","3RT30":"15.23","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"","34":"","48":"","15":"","46":"","23":"","18":"","22":"15.65","10":"","32":""},{"Metabolite":"Ornithine","CTRL2":"19.83","SD4":"18.61","2RT33":"19.17","3RT25":"18.65","3RT30":"20.2","SD1":"19.28","SD2":"18.94","2RT32":"20.35","14":"20","3RT39":"19.65","33":"20.29","34":"21.05","48":"20.64","15":"21.65","46":"20.94","23":"21.06","18":"19.08","22":"20.19","10":"20.41","32":"19.79"},{"Metabolite":"5,6 - Dimethylbenzimidazole","CTRL2":"18.01","SD4":"","2RT33":"16.74","3RT25":"16.9","3RT30":"14.99","SD1":"","SD2":"","2RT32":"15.76","14":"","3RT39":"16.09","33":"","34":"","48":"","15":"17.38","46":"","23":"","18":"","22":"16.96","10":"16.07","32":"16.44"},{"Metabolite":"deuterated Myristic Acid (RTL std)","CTRL2":"22.16","SD4":"22.24","2RT33":"22.22","3RT25":"22.18","3RT30":"22.31","SD1":"22.01","SD2":"22.18","2RT32":"22.21","14":"22.14","3RT39":"22.3","33":"22.03","34":"22.14","48":"22.15","15":"22.36","46":"22.14","23":"22.27","18":"22.13","22":"22.07","10":"22.14","32":"22.18"},{"Metabolite":"Dehydroascorbic acid","CTRL2":"20.94","SD4":"21.4","2RT33":"21.47","3RT25":"20.49","3RT30":"20.77","SD1":"20.61","SD2":"20.93","2RT32":"20.8","14":"21.5","3RT39":"21.56","33":"18.35","34":"19.15","48":"18.2","15":"19.66","46":"18.43","23":"18.37","18":"18.78","22":"19.42","10":"18.84","32":"19.35"},{"Metabolite":"Eicosamethylnonasiloxane","CTRL2":"","SD4":"","2RT33":"","3RT25":"14.07","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"","34":"","48":"13.97","15":"","46":"13.87","23":"","18":"12.85","22":"14.53","10":"14.21","32":""},{"Metabolite":"Myristic acid or Pentadecanol","CTRL2":"17.31","SD4":"17.55","2RT33":"17.67","3RT25":"17.53","3RT30":"17.78","SD1":"17.28","SD2":"17.61","2RT32":"17.26","14":"17.31","3RT39":"18.3","33":"17.63","34":"17.52","48":"17.6","15":"17.75","46":"17.97","23":"17.92","18":"17.38","22":"17.73","10":"17.6","32":"17.57"},{"Metabolite":"Methionine sulfoxide","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"15.11","34":"17.31","48":"","15":"","46":"","23":"","18":"","22":"","10":"16.51","32":""},{"Metabolite":"3,5-Dimethoxycinnamic acid","CTRL2":"","SD4":"","2RT33":"13.69","3RT25":"","3RT30":"13.85","SD1":"14.12","SD2":"","2RT32":"13.5","14":"14.55","3RT39":"","33":"","34":"","48":"","15":"","46":"14.56","23":"14.92","18":"14.06","22":"","10":"","32":"14"},{"Metabolite":"Fructose or similar ketohexose","CTRL2":"18.33","SD4":"18.47","2RT33":"18.34","3RT25":"18.35","3RT30":"18.53","SD1":"18.46","SD2":"18.86","2RT32":"17.67","14":"19.48","3RT39":"19.39","33":"17.45","34":"15.05","48":"16.53","15":"18.22","46":"18.12","23":"17.92","18":"16.47","22":"13.51","10":"","32":"16.93"},{"Metabolite":"Allantoin","CTRL2":"14.79","SD4":"","2RT33":"14.14","3RT25":"14.3","3RT30":"","SD1":"","SD2":"","2RT32":"14.45","14":"","3RT39":"14.19","33":"","34":"14.14","48":"12.96","15":"14.88","46":"12.69","23":"12.02","18":"","22":"","10":"","32":"13.48"},{"Metabolite":"Glucose and other aldohexoses","CTRL2":"27.69","SD4":"27.77","2RT33":"27.62","3RT25":"27.6","3RT30":"27.5","SD1":"27.69","SD2":"27.54","2RT32":"27.36","14":"27.68","3RT39":"27.72","33":"27.42","34":"27.42","48":"26.99","15":"27.89","46":"27.51","23":"27.48","18":"26.99","22":"26.9","10":"26.93","32":"27.4"},{"Metabolite":"Histidine","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"15.75","14":"","3RT39":"","33":"","34":"14.79","48":"15.99","15":"","46":"","23":"","18":"","22":"14.91","10":"13.12","32":""},{"Metabolite":"Lysine","CTRL2":"19.61","SD4":"18.01","2RT33":"19.52","3RT25":"18.71","3RT30":"20.73","SD1":"19.72","SD2":"18.14","2RT32":"20.8","14":"20.12","3RT39":"20.16","33":"20.01","34":"20.23","48":"20.39","15":"20.71","46":"20.2","23":"20.26","18":"19.57","22":"19.91","10":"19.94","32":"20.98"},{"Metabolite":"Hexuronic acid","CTRL2":"14.94","SD4":"15.88","2RT33":"17.14","3RT25":"17.46","3RT30":"17.09","SD1":"16.97","SD2":"15.99","2RT32":"17.88","14":"16.51","3RT39":"15.75","33":"18.41","34":"18.8","48":"18.52","15":"17.9","46":"17.74","23":"17.66","18":"17.75","22":"18.68","10":"18.39","32":"16.39"},{"Metabolite":"Tyrosine","CTRL2":"17.09","SD4":"16.11","2RT33":"17.71","3RT25":"17.4","3RT30":"19.15","SD1":"17.88","SD2":"16.68","2RT32":"18.62","14":"18.09","3RT39":"18.45","33":"18.34","34":"18.69","48":"19.19","15":"18.62","46":"18.13","23":"18.4","18":"17.87","22":"18.2","10":"18.29","32":"18.33"},{"Metabolite":"Pentadecanoic acid","CTRL2":"15.89","SD4":"16.55","2RT33":"16.55","3RT25":"16.43","3RT30":"16.7","SD1":"16.54","SD2":"16.81","2RT32":"16.23","14":"16.64","3RT39":"16.85","33":"","34":"16.11","48":"15.8","15":"","46":"16.54","23":"","18":"","22":"15.84","10":"16.25","32":"15.84"},{"Metabolite":"Sedoheptulose or similar sugar","CTRL2":"21.1","SD4":"21.33","2RT33":"20.9","3RT25":"20.87","3RT30":"20.62","SD1":"21.13","SD2":"21.53","2RT32":"20.61","14":"21.69","3RT39":"21.38","33":"20.75","34":"20.65","48":"20.25","15":"21.6","46":"20.89","23":"20.75","18":"20.09","22":"19.98","10":"20.01","32":"20.64"},{"Metabolite":"Gluconic acid or similar sugar acid","CTRL2":"21.11","SD4":"21.98","2RT33":"20.46","3RT25":"19.83","3RT30":"20.04","SD1":"21.27","SD2":"21.17","2RT32":"20.62","14":"22.23","3RT39":"22.6","33":"19.37","34":"20.27","48":"20.24","15":"20.4","46":"20.17","23":"20.58","18":"20.22","22":"20.2","10":"20.63","32":"19.7"},{"Metabolite":"Pantothenic acid","CTRL2":"15.07","SD4":"16.73","2RT33":"15.22","3RT25":"16.18","3RT30":"16.63","SD1":"15.97","SD2":"","2RT32":"15.81","14":"16.88","3RT39":"16.88","33":"15.38","34":"15.71","48":"17.46","15":"16.88","46":"16.5","23":"16.61","18":"16.2","22":"14.69","10":"14.59","32":"16.82"},{"Metabolite":"Xanthine","CTRL2":"20.54","SD4":"20.87","2RT33":"20.83","3RT25":"20.48","3RT30":"21.05","SD1":"21.09","SD2":"20.24","2RT32":"20.6","14":"21.74","3RT39":"21.62","33":"20.21","34":"19.88","48":"20.6","15":"18.54","46":"20.27","23":"20.57","18":"20.15","22":"19.53","10":"19.53","32":"20.81"},{"Metabolite":"Cytindine-5'-monophosphate","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"","34":"12.75","48":"13.08","15":"13.53","46":"13.25","23":"","18":"12.64","22":"13.36","10":"12.68","32":""},{"Metabolite":"Palmitoleic acid","CTRL2":"18.54","SD4":"16.5","2RT33":"17.71","3RT25":"18.23","3RT30":"17.9","SD1":"19.11","SD2":"17.92","2RT32":"17.11","14":"17.8","3RT39":"17.94","33":"","34":"","48":"","15":"","46":"","23":"15.33","18":"","22":"","10":"15.23","32":""},{"Metabolite":"5-Hydroxylysine","CTRL2":"13.44","SD4":"14.28","2RT33":"","3RT25":"14.25","3RT30":"14.45","SD1":"14.63","SD2":"14.48","2RT32":"13.89","14":"14.76","3RT39":"14.8","33":"11.78","34":"","48":"13.63","15":"","46":"13.3","23":"13.9","18":"13.1","22":"","10":"","32":"12.98"},{"Metabolite":"Palmitic acid","CTRL2":"23.86","SD4":"24.13","2RT33":"23.61","3RT25":"23.88","3RT30":"23.86","SD1":"24.36","SD2":"24.26","2RT32":"23.78","14":"24.11","3RT39":"24.28","33":"23.31","34":"23.14","48":"23.5","15":"23.59","46":"23.49","23":"23.56","18":"23.49","22":"23.3","10":"23.36","32":"23.45"},{"Metabolite":"Hexosamine","CTRL2":"16.78","SD4":"19.01","2RT33":"17.17","3RT25":"17.23","3RT30":"16.48","SD1":"18.61","SD2":"18.35","2RT32":"17.95","14":"18.02","3RT39":"18.92","33":"17.1","34":"16.73","48":"17.26","15":"18.61","46":"17.51","23":"18.42","18":"16.88","22":"17.99","10":"17.54","32":"19.02"},{"Metabolite":"Myoinositol","CTRL2":"22.03","SD4":"21.98","2RT33":"22.03","3RT25":"21.92","3RT30":"21.83","SD1":"21.88","SD2":"22.11","2RT32":"21.89","14":"22.07","3RT39":"22.19","33":"22.15","34":"22.15","48":"22.14","15":"22.92","46":"22.24","23":"22.44","18":"22","22":"22.24","10":"21.84","32":"22.94"},{"Metabolite":"Uric acid","CTRL2":"16.35","SD4":"14.14","2RT33":"14.3","3RT25":"15.68","3RT30":"15.86","SD1":"15.41","SD2":"14.72","2RT32":"15.47","14":"14.09","3RT39":"16.72","33":"","34":"","48":"14.45","15":"15.08","46":"13.04","23":"13.01","18":"","22":"13.72","10":"","32":"16.19"},{"Metabolite":"Ketopentose-5-phosphate","CTRL2":"16.54","SD4":"15.62","2RT33":"16.58","3RT25":"16.81","3RT30":"15.16","SD1":"15.06","SD2":"14.27","2RT32":"16.25","14":"14.3","3RT39":"15.94","33":"15.17","34":"15.69","48":"17.15","15":"17.29","46":"16.26","23":"16.07","18":"16.25","22":"17.33","10":"16.44","32":"16.85"},{"Metabolite":"Normetanephrine","CTRL2":"","SD4":"13.43","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"12.56","2RT32":"","14":"13.23","3RT39":"","33":"","34":"","48":"","15":"12.62","46":"","23":"12.46","18":"","22":"","10":"","32":""},{"Metabolite":"Heptadecanoic acid/Octadecanol","CTRL2":"18.01","SD4":"18.4","2RT33":"18.2","3RT25":"18.12","3RT30":"17.95","SD1":"18.22","SD2":"18.6","2RT32":"18.27","14":"18.33","3RT39":"18.41","33":"18.41","34":"18.42","48":"18.71","15":"18.83","46":"18.62","23":"18.66","18":"18.59","22":"18.66","10":"18.71","32":"18.57"},{"Metabolite":"N1-Methyltryptamine","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"","34":"12.54","48":"12.82","15":"","46":"12.91","23":"11.93","18":"12.98","22":"13.87","10":"","32":""},{"Metabolite":"Glutathione (reduced)","CTRL2":"16.44","SD4":"15.28","2RT33":"15.93","3RT25":"","3RT30":"14.27","SD1":"","SD2":"16.35","2RT32":"15.61","14":"14.7","3RT39":"14.31","33":"","34":"","48":"","15":"14.2","46":"","23":"","18":"","22":"","10":"","32":""},{"Metabolite":"C22 hydrocarbon","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"13.85","33":"","34":"","48":"12.97","15":"13.55","46":"","23":"","18":"","22":"","10":"","32":""},{"Metabolite":"Phytol","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"","34":"","48":"13.49","15":"12.14","46":"14.03","23":"13.19","18":"13.38","22":"12.6","10":"12.02","32":"12.94"},{"Metabolite":"Spermidine","CTRL2":"19.51","SD4":"18.5","2RT33":"19.28","3RT25":"18.91","3RT30":"18.94","SD1":"19.23","SD2":"19.36","2RT32":"19.34","14":"19.15","3RT39":"19.4","33":"19.56","34":"20.85","48":"19.42","15":"20.29","46":"19.95","23":"20.24","18":"19.79","22":"20","10":"20.77","32":"21.27"},{"Metabolite":"3-Indolelactic acid/tryptophan","CTRL2":"","SD4":"","2RT33":"15.46","3RT25":"15.34","3RT30":"15.56","SD1":"16.12","SD2":"15.66","2RT32":"15.52","14":"16.13","3RT39":"15.88","33":"","34":"","48":"13.14","15":"","46":"","23":"","18":"14.1","22":"","10":"13.5","32":"14.78"},{"Metabolite":"Linoleic acid","CTRL2":"20.63","SD4":"21.79","2RT33":"20.53","3RT25":"21.28","3RT30":"21.16","SD1":"21.52","SD2":"21.64","2RT32":"20.65","14":"22.44","3RT39":"22.47","33":"20.07","34":"20.95","48":"20.83","15":"20.5","46":"21.23","23":"21.64","18":"21.13","22":"21.13","10":"21.15","32":"20.65"},{"Metabolite":"Oleic acid","CTRL2":"19.92","SD4":"21.36","2RT33":"20.33","3RT25":"20.94","3RT30":"21.47","SD1":"20.85","SD2":"20.95","2RT32":"20.47","14":"21.56","3RT39":"21.45","33":"20.02","34":"20.81","48":"20.38","15":"20.08","46":"20.97","23":"21.34","18":"21.1","22":"20.88","10":"21.25","32":"19.68"},{"Metabolite":"Stearic acid","CTRL2":"23.53","SD4":"23.65","2RT33":"23.74","3RT25":"23.55","3RT30":"23.6","SD1":"23.68","SD2":"23.71","2RT32":"23.63","14":"23.65","3RT39":"23.63","33":"23.82","34":"23.76","48":"23.85","15":"24.15","46":"23.7","23":"23.8","18":"24.09","22":"23.81","10":"23.78","32":"23.77"},{"Metabolite":"Cystine","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"","34":"17.12","48":"19.07","15":"","46":"16.67","23":"17.06","18":"","22":"16.38","10":"16.33","32":"17.35"},{"Metabolite":"Glucose-6-phosphate or similar","CTRL2":"20.54","SD4":"16.85","2RT33":"18.37","3RT25":"19.06","3RT30":"17.35","SD1":"17.85","SD2":"17.53","2RT32":"17.37","14":"17.7","3RT39":"18.49","33":"16.62","34":"15.87","48":"14.63","15":"19.61","46":"15.9","23":"15.25","18":"15.11","22":"14.4","10":"","32":"18.06"},{"Metabolite":"2-Aminoethanethiol/Glycylphenylalanine","CTRL2":"","SD4":"13.43","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"12.97","14":"","3RT39":"","33":"","34":"","48":"","15":"12.38","46":"","23":"","18":"","22":"12","10":"","32":""},{"Metabolite":"1-Eicosanol","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"14.65","2RT32":"","14":"","3RT39":"14.78","33":"16.12","34":"","48":"","15":"","46":"","23":"","18":"","22":"","10":"15.26","32":""},{"Metabolite":"Arachidonic acid (also Eicosapentaenoic acid)","CTRL2":"20.75","SD4":"21.49","2RT33":"20.94","3RT25":"21.15","3RT30":"21.11","SD1":"21.09","SD2":"21.2","2RT32":"20.96","14":"21.99","3RT39":"21.57","33":"19.68","34":"20.76","48":"20.7","15":"21.11","46":"20.47","23":"20.81","18":"20.78","22":"20.65","10":"20.89","32":"20.59"},{"Metabolite":"Purine riboside","CTRL2":"19.68","SD4":"20.09","2RT33":"19.97","3RT25":"18.17","3RT30":"20.6","SD1":"18.89","SD2":"19.16","2RT32":"20.47","14":"20.5","3RT39":"20.78","33":"19.34","34":"20.1","48":"20.9","15":"19.56","46":"20.56","23":"20.75","18":"19.94","22":"19.94","10":"20.02","32":"20.36"},{"Metabolite":"Myoinositol-2-phosphate","CTRL2":"17.2","SD4":"17.89","2RT33":"17.9","3RT25":"17.73","3RT30":"17.3","SD1":"17.98","SD2":"17.82","2RT32":"17.32","14":"18.57","3RT39":"18.2","33":"16.67","34":"17.53","48":"16.89","15":"17.3","46":"17.33","23":"17.66","18":"17.82","22":"17.34","10":"17.57","32":"17.04"},{"Metabolite":"6-Phosphogluconic acid","CTRL2":"16.05","SD4":"15.92","2RT33":"14.81","3RT25":"14.92","3RT30":"17.3","SD1":"18.96","SD2":"17.17","2RT32":"13.14","14":"15.97","3RT39":"16.48","33":"16.67","34":"","48":"16.89","15":"16.21","46":"17.33","23":"17.66","18":"17.82","22":"17.34","10":"","32":"15.97"},{"Metabolite":"Arachidic acid","CTRL2":"15.23","SD4":"14.22","2RT33":"13.18","3RT25":"17.07","3RT30":"17.05","SD1":"15.25","SD2":"14.92","2RT32":"15.16","14":"15.16","3RT39":"16.6","33":"15.59","34":"16.33","48":"16.98","15":"15.73","46":"16.14","23":"15.79","18":"15.76","22":"16.34","10":"16.01","32":"15.81"},{"Metabolite":"Uridine/pseudouridine","CTRL2":"20.4","SD4":"20.78","2RT33":"21.01","3RT25":"21.08","3RT30":"20.26","SD1":"21.26","SD2":"21.56","2RT32":"20.62","14":"21.46","3RT39":"20.68","33":"19.02","34":"18.18","48":"18.59","15":"18.92","46":"19.3","23":"19.68","18":"19.75","22":"18.94","10":"18.9","32":"19.24"},{"Metabolite":"Neohesperidin or similar flavonone","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"14.83","SD2":"","2RT32":"13.93","14":"15.8","3RT39":"","33":"","34":"","48":"","15":"","46":"","23":"","18":"","22":"","10":"","32":""},{"Metabolite":"beta-Monopalmitin","CTRL2":"16.34","SD4":"15.67","2RT33":"16.57","3RT25":"16.2","3RT30":"15.9","SD1":"16.45","SD2":"15.74","2RT32":"15.62","14":"16.46","3RT39":"15.14","33":"16.65","34":"15.5","48":"17.17","15":"16.62","46":"16.83","23":"16.84","18":"17.14","22":"16.62","10":"17.2","32":""},{"Metabolite":"Docosahexaenoic acid","CTRL2":"17.88","SD4":"19.18","2RT33":"19.17","3RT25":"18.7","3RT30":"19.94","SD1":"18.56","SD2":"19.5","2RT32":"19.26","14":"20.06","3RT39":"19.35","33":"18.99","34":"20.3","48":"21.08","15":"20.51","46":"20.64","23":"20.64","18":"20.34","22":"20.5","10":"20.43","32":"20.53"},{"Metabolite":"Inosine/Adenosine","CTRL2":"23.63","SD4":"23.43","2RT33":"23.69","3RT25":"23.86","3RT30":"23.42","SD1":"23.09","SD2":"23.23","2RT32":"23.43","14":"23.09","3RT39":"23.43","33":"23.07","34":"23.56","48":"23.82","15":"23.37","46":"23.7","23":"23.61","18":"23.69","22":"23.75","10":"23.58","32":"23.71"},{"Metabolite":"alpha-Monopalmitin","CTRL2":"21.51","SD4":"21.37","2RT33":"21.51","3RT25":"21.33","3RT30":"21.34","SD1":"21.53","SD2":"21.4","2RT32":"21.36","14":"21.39","3RT39":"21.46","33":"21.45","34":"21.27","48":"21.23","15":"21.51","46":"21.35","23":"21.52","18":"21.58","22":"21.66","10":"21.47","32":"21.58"},{"Metabolite":"N-Acetylneuraminic acid","CTRL2":"13.61","SD4":"13.72","2RT33":"14.8","3RT25":"16","3RT30":"15.99","SD1":"14.82","SD2":"","2RT32":"15.24","14":"16.39","3RT39":"16.26","33":"15.18","34":"13.89","48":"15.54","15":"16.91","46":"15.17","23":"16.08","18":"14.4","22":"15.86","10":"","32":"18.1"},{"Metabolite":"Docosanoic acid","CTRL2":"","SD4":"","2RT33":"10.93","3RT25":"","3RT30":"","SD1":"11.1","SD2":"","2RT32":"","14":"","3RT39":"","33":"12.22","34":"12.27","48":"","15":"12.84","46":"11.34","23":"","18":"","22":"","10":"11.26","32":"12.46"},{"Metabolite":"Phytosphingosine","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"13.24","SD1":"13.52","SD2":"","2RT32":"13.23","14":"15.32","3RT39":"14.36","33":"","34":"","48":"","15":"","46":"","23":"","18":"","22":"","10":"","32":""},{"Metabolite":"Xanthosine","CTRL2":"18.67","SD4":"17.16","2RT33":"16.1","3RT25":"19.46","3RT30":"19.29","SD1":"16.95","SD2":"17.1","2RT32":"17.5","14":"16.57","3RT39":"18.81","33":"12.86","34":"14.73","48":"14.02","15":"","46":"","23":"13.82","18":"14.24","22":"14.88","10":"12.56","32":"14.21"},{"Metabolite":"beta-Monostearin","CTRL2":"","SD4":"","2RT33":"","3RT25":"17.88","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"18.93","34":"19.02","48":"19","15":"18.99","46":"18.75","23":"18.89","18":"19.68","22":"19.57","10":"19.07","32":"19.35"},{"Metabolite":"Disaccharide","CTRL2":"20.88","SD4":"21.79","2RT33":"21.37","3RT25":"21.64","3RT30":"21.1","SD1":"22.05","SD2":"21.52","2RT32":"21.93","14":"22.13","3RT39":"21.47","33":"19.08","34":"16.16","48":"20.7","15":"17.59","46":"18.72","23":"18.43","18":"20.95","22":"18.92","10":"19.63","32":"21.19"},{"Metabolite":"Maltose or similar disaccharide","CTRL2":"22.63","SD4":"23.58","2RT33":"23.17","3RT25":"22.74","3RT30":"22.91","SD1":"23.49","SD2":"23.53","2RT32":"22.82","14":"24.47","3RT39":"23.9","33":"21.16","34":"19.71","48":"19.33","15":"19.78","46":"21.36","23":"21.82","18":"19.51","22":"18.56","10":"18.84","32":"20.1"},{"Metabolite":"alpha-Monostearin","CTRL2":"24.08","SD4":"24.08","2RT33":"24.06","3RT25":"24.01","3RT30":"24.03","SD1":"23.96","SD2":"23.97","2RT32":"24.14","14":"23.77","3RT39":"24.05","33":"24.03","34":"24.09","48":"23.94","15":"24.26","46":"24.16","23":"24.31","18":"24.35","22":"24.26","10":"24.29","32":"24.23"},{"Metabolite":"Uridine 5'-monophosphate","CTRL2":"17.69","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"","34":"19.26","48":"","15":"20.42","46":"","23":"","18":"","22":"18.93","10":"18.99","32":"19.09"},{"Metabolite":"Squalene","CTRL2":"","SD4":"16.38","2RT33":"16.3","3RT25":"16.93","3RT30":"15.72","SD1":"16.17","SD2":"16.62","2RT32":"16.02","14":"16.23","3RT39":"17.02","33":"17.7","34":"","48":"19.57","15":"20.42","46":"19.71","23":"18.15","18":"17.9","22":"","10":"18.99","32":""},{"Metabolite":"Tetracosanoic acid","CTRL2":"11.64","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"","34":"12.82","48":"","15":"14.45","46":"11.7","23":"12.43","18":"","22":"","10":"","32":"13.8"},{"Metabolite":"Isomaltose or similar disaccharide","CTRL2":"15.09","SD4":"15.9","2RT33":"15.55","3RT25":"15.15","3RT30":"15.18","SD1":"16.13","SD2":"15.83","2RT32":"15.44","14":"17.19","3RT39":"16.13","33":"15.67","34":"16.14","48":"16.32","15":"17.11","46":"16.52","23":"16.54","18":"15.72","22":"16.14","10":"15.21","32":"16.63"},{"Metabolite":"Prunetin or similar isoflavone","CTRL2":"","SD4":"","2RT33":"12.69","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"","34":"","48":"","15":"12.78","46":"","23":"","18":"","22":"","10":"","32":"12.41"},{"Metabolite":"Flavanoid or short-chain cholesterol ester","CTRL2":"","SD4":"13.68","2RT33":"12.55","3RT25":"","3RT30":"12.34","SD1":"","SD2":"","2RT32":"","14":"13.39","3RT39":"13.28","33":"15.82","34":"13.9","48":"","15":"","46":"14.83","23":"13.35","18":"15.8","22":"15.57","10":"13.72","32":""},{"Metabolite":"Adenosine-5'-monophosphate","CTRL2":"","SD4":"","2RT33":"","3RT25":"12.37","3RT30":"14.48","SD1":"","SD2":"","2RT32":"","14":"15.62","3RT39":"13.6","33":"14.93","34":"17.69","48":"16.96","15":"18.23","46":"16.42","23":"16.03","18":"15.94","22":"18.03","10":"17.5","32":"16.69"},{"Metabolite":"5-Cholesten-3-beta-7-alpha-diol","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"16.3","34":"","48":"","15":"13.97","46":"","23":"","18":"15.84","22":"","10":"13.23","32":""},{"Metabolite":"alpha-Tocopherol","CTRL2":"17.45","SD4":"17.46","2RT33":"16.61","3RT25":"17.05","3RT30":"16.06","SD1":"17.11","SD2":"17.33","2RT32":"16.64","14":"17.01","3RT39":"17.31","33":"15.99","34":"16.68","48":"17.73","15":"16.32","46":"16.87","23":"17.04","18":"16.07","22":"17.12","10":"16.51","32":"16.58"},{"Metabolite":"Cholesterol","CTRL2":"24.47","SD4":"24.74","2RT33":"24.61","3RT25":"24.41","3RT30":"24.5","SD1":"24.53","SD2":"24.61","2RT32":"24.57","14":"24.88","3RT39":"24.66","33":"24.3","34":"24.38","48":"24.57","15":"24.83","46":"24.41","23":"24.46","18":"24.52","22":"24.75","10":"24.5","32":"24.93"},{"Metabolite":"5-alpha-Coprostanol or similar oxysterol","CTRL2":"","SD4":"","2RT33":"","3RT25":"14.4","3RT30":"15.24","SD1":"14.61","SD2":"13.96","2RT32":"15.38","14":"","3RT39":"","33":"","34":"","48":"","15":"","46":"","23":"","18":"","22":"","10":"","32":""},{"Metabolite":"Campesterol","CTRL2":"19.1","SD4":"18.56","2RT33":"18.58","3RT25":"19.7","3RT30":"17.68","SD1":"19.17","SD2":"18.67","2RT32":"18.12","14":"19.58","3RT39":"18.87","33":"19.05","34":"19.19","48":"20.03","15":"18.91","46":"19.31","23":"19.46","18":"19.12","22":"20","10":"19.27","32":"19.27"},{"Metabolite":"Cholic acid or similar bile acid","CTRL2":"","SD4":"","2RT33":"","3RT25":"","3RT30":"16.58","SD1":"","SD2":"","2RT32":"","14":"","3RT39":"","33":"14.97","34":"13.51","48":"18.16","15":"13.49","46":"15.27","23":"","18":"15.26","22":"18.54","10":"16.93","32":"12.7"},{"Metabolite":"beta-Sitosterol","CTRL2":"19.04","SD4":"18.05","2RT33":"17.73","3RT25":"19.32","3RT30":"17.32","SD1":"18.6","SD2":"17.8","2RT32":"17.24","14":"18.88","3RT39":"18.72","33":"18.27","34":"18.27","48":"19.2","15":"18.17","46":"18.49","23":"18.84","18":"18.21","22":"19.02","10":"18.66","32":"18.37"},{"Metabolite":"Melezitose","CTRL2":"15.37","SD4":"16.58","2RT33":"17.09","3RT25":"","3RT30":"15.63","SD1":"17.25","SD2":"17.1","2RT32":"16.25","14":"19.18","3RT39":"19.03","33":"","34":"","48":"","15":"","46":"","23":"","18":"","22":"","10":"","32":""},{"Metabolite":"Trisaccharide","CTRL2":"24.16","SD4":"24.73","2RT33":"24.64","3RT25":"24.23","3RT30":"24.26","SD1":"24.81","SD2":"24.9","2RT32":"24.14","14":"25.61","3RT39":"25.41","33":"21.14","34":"19.84","48":"18.05","15":"20.62","46":"21.39","23":"22.45","18":"18.72","22":"17.32","10":"18.04","32":"20.87"}],

"Metabolites":[{"metabolite_name":"Decamethyltetrasiloxane"},{"metabolite_name":"2-Hydroxypyridine"},{"metabolite_name":"Pyruvic acid"},{"metabolite_name":"Phenol"},{"metabolite_name":"Lactic acid"},{"metabolite_name":"C10 hydrocarbon"},{"metabolite_name":"Alanine"},{"metabolite_name":"C11 hydrocarbon"},{"metabolite_name":"2-Hydroxybutyric acid"},{"metabolite_name":"beta-Hydroxybutyric acid"},{"metabolite_name":"2-Aminobutanoic acid"},{"metabolite_name":"O-Methylphosphate"},{"metabolite_name":"Malonic acid"},{"metabolite_name":"Valine"},{"metabolite_name":"C12 hydrocarbon"},{"metabolite_name":"Urea"},{"metabolite_name":"Benzoic acid"},{"metabolite_name":"Ethanolamine"},{"metabolite_name":"Pipecolic acid"},{"metabolite_name":"Phosphoric acid"},{"metabolite_name":"Glycerol"},{"metabolite_name":"C13 hydrocarbon"},{"metabolite_name":"Isoleucine/Leucine"},{"metabolite_name":"Proline"},{"metabolite_name":"Glycine"},{"metabolite_name":"Succinic acid"},{"metabolite_name":"Glyceric acid"},{"metabolite_name":"MSTFA artifact"},{"metabolite_name":"Uracil"},{"metabolite_name":"Fumaric acid"},{"metabolite_name":"Serine"},{"metabolite_name":"Nonanoic acid"},{"metabolite_name":"Threonine"},{"metabolite_name":"Hydroquinone or Resorcinol"},{"metabolite_name":"6-Methyluracil"},{"metabolite_name":"Methionine"},{"metabolite_name":"Aspartic acid"},{"metabolite_name":"beta-Alanine"},{"metabolite_name":"Threose/erythrose"},{"metabolite_name":"Aminomalonic acid"},{"metabolite_name":"Aspartic acid ???"},{"metabolite_name":"Nicotinamide"},{"metabolite_name":"Malic acid"},{"metabolite_name":"C15 hydrocarbon"},{"metabolite_name":"Threitol/erythritol"},{"metabolite_name":"Salicylic acid"},{"metabolite_name":"Glutamic acid"},{"metabolite_name":"Hydroxyprolines"},{"metabolite_name":"Erythronic acid"},{"metabolite_name":"Hexadecamethylheptasiloxane"},{"metabolite_name":"7H-Purine/Phenylalanine"},{"metabolite_name":"Cysteine/Creatinine"},{"metabolite_name":"Threonic acid"},{"metabolite_name":"2-Hydroxyglutaric acid"},{"metabolite_name":"6-Hydroxynicotinic acid"},{"metabolite_name":"Phosphoenolpyruvic acid"},{"metabolite_name":"2-Hydroxybiphenyl"},{"metabolite_name":"Hypotaurine"},{"metabolite_name":"Phenylalanine"},{"metabolite_name":"5-Aminovaleric acid"},{"metabolite_name":"N-Acetylaspartic acid"},{"metabolite_name":"trans,trans-Muconic acid"},{"metabolite_name":"Pyrophosphate"},{"metabolite_name":"Taurine"},{"metabolite_name":"Aldopentoses"},{"metabolite_name":"Cysteinesulfinic acid"},{"metabolite_name":"Octadecamethyloctasiloxane"},{"metabolite_name":"2-Aminoadipic acid"},{"metabolite_name":"N-Methylglutamic acid"},{"metabolite_name":"Pentitols"},{"metabolite_name":"Glycerol 1-phosphate"},{"metabolite_name":"Glutamine"},{"metabolite_name":"2-Phosphoglyceric acid"},{"metabolite_name":"Pentonic acids"},{"metabolite_name":"N-Acetylglutamic acid"},{"metabolite_name":"O-Phosphocolamine"},{"metabolite_name":"Gentisic acid"},{"metabolite_name":"Hypoxanthine"},{"metabolite_name":"Epinephrine"},{"metabolite_name":"Cysteinylglycine"},{"metabolite_name":"Ornithine"},{"metabolite_name":"5,6 - Dimethylbenzimidazole"},{"metabolite_name":"deuterated Myristic Acid (RTL std)"},{"metabolite_name":"Dehydroascorbic acid"},{"metabolite_name":"Eicosamethylnonasiloxane"},{"metabolite_name":"Myristic acid or Pentadecanol"},{"metabolite_name":"Methionine sulfoxide"},{"metabolite_name":"3,5-Dimethoxycinnamic acid"},{"metabolite_name":"Fructose or similar ketohexose"},{"metabolite_name":"Allantoin"},{"metabolite_name":"Glucose and other aldohexoses"},{"metabolite_name":"Histidine"},{"metabolite_name":"Lysine"},{"metabolite_name":"Hexuronic acid"},{"metabolite_name":"Tyrosine"},{"metabolite_name":"Pentadecanoic acid"},{"metabolite_name":"Sedoheptulose or similar sugar"},{"metabolite_name":"Gluconic acid or similar sugar acid"},{"metabolite_name":"Pantothenic acid"},{"metabolite_name":"Xanthine"},{"metabolite_name":"Cytindine-5'-monophosphate"},{"metabolite_name":"Palmitoleic acid"},{"metabolite_name":"5-Hydroxylysine"},{"metabolite_name":"Palmitic acid"},{"metabolite_name":"Hexosamine"},{"metabolite_name":"Myoinositol"},{"metabolite_name":"Uric acid"},{"metabolite_name":"Ketopentose-5-phosphate"},{"metabolite_name":"Normetanephrine"},{"metabolite_name":"Heptadecanoic acid/Octadecanol"},{"metabolite_name":"N1-Methyltryptamine"},{"metabolite_name":"Glutathione (reduced)"},{"metabolite_name":"C22 hydrocarbon"},{"metabolite_name":"Phytol"},{"metabolite_name":"Spermidine"},{"metabolite_name":"3-Indolelactic acid/tryptophan"},{"metabolite_name":"Linoleic acid"},{"metabolite_name":"Oleic acid"},{"metabolite_name":"Stearic acid"},{"metabolite_name":"Cystine"},{"metabolite_name":"Glucose-6-phosphate or similar"},{"metabolite_name":"2-Aminoethanethiol/Glycylphenylalanine"},{"metabolite_name":"1-Eicosanol"},{"metabolite_name":"Arachidonic acid (also Eicosapentaenoic acid)"},{"metabolite_name":"Purine riboside"},{"metabolite_name":"Myoinositol-2-phosphate"},{"metabolite_name":"6-Phosphogluconic acid"},{"metabolite_name":"Arachidic acid"},{"metabolite_name":"Uridine/pseudouridine"},{"metabolite_name":"Neohesperidin or similar flavonone"},{"metabolite_name":"beta-Monopalmitin"},{"metabolite_name":"Docosahexaenoic acid"},{"metabolite_name":"Inosine/Adenosine"},{"metabolite_name":"alpha-Monopalmitin"},{"metabolite_name":"N-Acetylneuraminic acid"},{"metabolite_name":"Docosanoic acid"},{"metabolite_name":"Phytosphingosine"},{"metabolite_name":"Xanthosine"},{"metabolite_name":"beta-Monostearin"},{"metabolite_name":"Disaccharide"},{"metabolite_name":"Maltose or similar disaccharide"},{"metabolite_name":"alpha-Monostearin"},{"metabolite_name":"Uridine 5'-monophosphate"},{"metabolite_name":"Squalene"},{"metabolite_name":"Tetracosanoic acid"},{"metabolite_name":"Isomaltose or similar disaccharide"},{"metabolite_name":"Prunetin or similar isoflavone"},{"metabolite_name":"Flavanoid or short-chain cholesterol ester"},{"metabolite_name":"Adenosine-5'-monophosphate"},{"metabolite_name":"5-Cholesten-3-beta-7-alpha-diol"},{"metabolite_name":"alpha-Tocopherol"},{"metabolite_name":"Cholesterol"},{"metabolite_name":"5-alpha-Coprostanol or similar oxysterol"},{"metabolite_name":"Campesterol"},{"metabolite_name":"Cholic acid or similar bile acid"},{"metabolite_name":"beta-Sitosterol"},{"metabolite_name":"Melezitose"},{"metabolite_name":"Trisaccharide"}]
}

}