{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000375","ANALYSIS_ID":"AN000609","VERSION":"1","CREATED_ON":"April 19, 2016, 3:02 pm"},

"PROJECT":{"PROJECT_TITLE":"Metabolomics Mice Studies","PROJECT_SUMMARY":"Analysis of glycolysis/TCA cycle in skeletal muscle + acyl-carnitine in serum of wt and 113Q mice","INSTITUTE":"University of Michigan","DEPARTMENT":"Pathology","LABORATORY":"Lieberman, Andrew","LAST_NAME":"Lieberman","FIRST_NAME":"Andrew","ADDRESS":"Ann Arbor, MI","EMAIL":"liebermn@umich.edu","PHONE":"734-936-1889"},

"STUDY":{"STUDY_TITLE":"Mice exercise metabolomics (part II)","STUDY_TYPE":"Regular","STUDY_SUMMARY":"Mice were run for 15 minutes on a treadmill and then mice were induced into anesthesia at a dose of 5% isoflurane, then maintained by continuous inhalation of 2% isoflurane. Quadriceps muscle was collected first and flash frozen in liquid nitrogen. Then blood was collected from the left ventricle of the heart and placed into serum separating tubes. Blood was allowed to clot for 40 minutes and centrifuged, the supernatant was frozen in liquid nitrogen","INSTITUTE":"University of Michigan","DEPARTMENT":"Biomedical Research Core Facilities","LABORATORY":"Metabolomics core","LAST_NAME":"Kachman","FIRST_NAME":"Maureen","ADDRESS":"6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714","EMAIL":"mkachman@med.umich.edu","PHONE":"(734) 232-8175","NUM_GROUPS":"4","TOTAL_SUBJECTS":"18"},

"SUBJECT":{"SUBJECT_TYPE":"Animal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"SU0012359",
"Sample ID":"S00018461",
"Factors":{"Wild Type":"yes","Mutants":"no"}
},
{
"Subject ID":"SU0012360",
"Sample ID":"S00018462",
"Factors":{"Wild Type":"yes","Mutants":"no"}
},
{
"Subject ID":"SU0012361",
"Sample ID":"S00018463",
"Factors":{"Wild Type":"yes","Mutants":"no"}
},
{
"Subject ID":"SU0012362",
"Sample ID":"S00018464",
"Factors":{"Wild Type":"yes","Mutants":"no"}
},
{
"Subject ID":"SU0012363",
"Sample ID":"S00018465",
"Factors":{"Wild Type":"no","Mutants":"yes"}
},
{
"Subject ID":"SU0012364",
"Sample ID":"S00018466",
"Factors":{"Wild Type":"no","Mutants":"yes"}
},
{
"Subject ID":"SU0012365",
"Sample ID":"S00018467",
"Factors":{"Wild Type":"no","Mutants":"yes"}
},
{
"Subject ID":"SU0012366",
"Sample ID":"S00018468",
"Factors":{"Wild Type":"no","Mutants":"yes"}
},
{
"Subject ID":"SU0012359",
"Sample ID":"S00018469",
"Factors":{"Wild Type":"yes","Mutants":"no"}
},
{
"Subject ID":"SU0012360",
"Sample ID":"S00018470",
"Factors":{"Wild Type":"yes","Mutants":"no"}
},
{
"Subject ID":"SU0012361",
"Sample ID":"S00018471",
"Factors":{"Wild Type":"yes","Mutants":"no"}
},
{
"Subject ID":"SU0012362",
"Sample ID":"S00018472",
"Factors":{"Wild Type":"yes","Mutants":"no"}
},
{
"Subject ID":"SU0012363",
"Sample ID":"S00018473",
"Factors":{"Wild Type":"no","Mutants":"yes"}
},
{
"Subject ID":"SU0012364",
"Sample ID":"S00018474",
"Factors":{"Wild Type":"no","Mutants":"yes"}
},
{
"Subject ID":"SU0012365",
"Sample ID":"S00018475",
"Factors":{"Wild Type":"no","Mutants":"yes"}
},
{
"Subject ID":"SU0012366",
"Sample ID":"S00018476",
"Factors":{"Wild Type":"no","Mutants":"yes"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"NONE","SAMPLE_TYPE":"Serum"},

"TREATMENT":{"TREATMENT_SUMMARY":"None"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"none","SAMPLEPREP_PROTOCOL_FILENAME":"Gly-TCA-nucleotides analysis protocol-2015-03-09.docx"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"None","INSTRUMENT_NAME":"QTOF-002-HILIC-35min-1mm-No Insert.m.zip","COLUMN_NAME":"Phenomenex Luna NH2 (150 x 1mm, 3um)","METHODS_ID":"DQM0166"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","ANALYSIS_PROTOCOL_FILE":"QTOF-002-HILIC-35min-1mm-No Insert.m.zip"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Agilent 6410A QQQ","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","ION_MODE":"NEGATIVE"},

"MS_METABOLITE_DATA":{
"Units":"pmol/mg tissue",

"Data":[{"Metabolite":"2 or 3-phosphoglycerate","S00018469":"2.287","S00018470":"0.601","S00018471":"1.617","S00018472":"1.770","S00018473":"1.250","S00018474":"0.889","S00018475":"1.819","S00018476":"0.801"},{"Metabolite":"6-phosphogluconate","S00018469":"7.399","S00018470":"7.198","S00018471":"8.152","S00018472":"7.461","S00018473":"7.076","S00018474":"7.302","S00018475":"7.475","S00018476":"7.130"},{"Metabolite":"acetyl-coa","S00018469":"","S00018470":"","S00018471":"","S00018472":"","S00018473":"","S00018474":"","S00018475":"","S00018476":""},{"Metabolite":"adenosine diphosphate","S00018469":"95.155","S00018470":"63.713","S00018471":"71.123","S00018472":"60.065","S00018473":"51.669","S00018474":"66.962","S00018475":"80.071","S00018476":"70.488"},{"Metabolite":"adenosine monophosphate","S00018469":"52.512","S00018470":"4.211","S00018471":"21.349","S00018472":"31.086","S00018473":"25.919","S00018474":"27.713","S00018475":"44.820","S00018476":"31.979"},{"Metabolite":"adenosine triphosphate","S00018469":"2.158","S00018470":"2.308","S00018471":"3.137","S00018472":"3.259","S00018473":"2.036","S00018474":"2.810","S00018475":"3.619","S00018476":"2.114"},{"Metabolite":"citrate or isocitrate","S00018469":"221.192","S00018470":"235.857","S00018471":"137.673","S00018472":"100.820","S00018473":"183.330","S00018474":"162.433","S00018475":"126.434","S00018476":"116.209"},{"Metabolite":"erythrose 4-phosphate","S00018469":"7.695","S00018470":"19.532","S00018471":"17.975","S00018472":"18.527","S00018473":"27.396","S00018474":"11.619","S00018475":"13.400","S00018476":"14.021"},{"Metabolite":"glucose 6-phosphate or fructose-6-phosphate","S00018469":"6.693","S00018470":"9.202","S00018471":"7.663","S00018472":"7.470","S00018473":"8.534","S00018474":"6.363","S00018475":"6.848","S00018476":"6.954"},{"Metabolite":"flavin adenine dinucleotide","S00018469":"2.338","S00018470":"3.334","S00018471":"1.699","S00018472":"2.482","S00018473":"2.492","S00018474":"1.751","S00018475":"1.830","S00018476":"1.754"},{"Metabolite":"fructose 1,6-bisphosphate","S00018469":"21.110","S00018470":"18.351","S00018471":"22.241","S00018472":"19.877","S00018473":"17.386","S00018474":"18.850","S00018475":"19.063","S00018476":"18.546"},{"Metabolite":"malate","S00018469":"63.219","S00018470":"99.217","S00018471":"38.470","S00018472":"67.778","S00018473":"97.975","S00018474":"37.941","S00018475":"51.511","S00018476":"38.968"},{"Metabolite":"nicotinamide adenine dinucleotide oxidized","S00018469":"25.118","S00018470":"8.027","S00018471":"18.917","S00018472":"16.636","S00018473":"6.957","S00018474":"12.091","S00018475":"9.170","S00018476":"9.217"},{"Metabolite":"nicotinamide adenine dinucleotide reduced","S00018469":"0.208","S00018470":"0.090","S00018471":"0.347","S00018472":"0.259","S00018473":"0.070","S00018474":"0.300","S00018475":"0.211","S00018476":"0.232"},{"Metabolite":"nicotinamide adenine dinucleotide phosphate oxidized","S00018469":"0.607","S00018470":"0.191","S00018471":"0.597","S00018472":"0.488","S00018473":"0.250","S00018474":"0.310","S00018475":"0.522","S00018476":"0.291"},{"Metabolite":"nicotinamide adenine dinucleotide phosphate reduced","S00018469":"","S00018470":"","S00018471":"","S00018472":"","S00018473":"","S00018474":"","S00018475":"","S00018476":""},{"Metabolite":"phosphoenolpyruvate","S00018469":"","S00018470":"","S00018471":"","S00018472":"","S00018473":"","S00018474":"","S00018475":"","S00018476":""},{"Metabolite":"ribose-5-phosphate or xylulose 5-phosphate","S00018469":"118.434","S00018470":"144.870","S00018471":"96.410","S00018472":"118.674","S00018473":"115.499","S00018474":"128.752","S00018475":"97.159","S00018476":"86.947"},{"Metabolite":"sedoheptulose 7-phosphate","S00018469":"1.680","S00018470":"1.788","S00018471":"1.009","S00018472":"1.315","S00018473":"2.725","S00018474":"1.746","S00018475":"2.269","S00018476":"1.275"},{"Metabolite":"sucrose","S00018469":"","S00018470":"","S00018471":"","S00018472":"","S00018473":"","S00018474":"","S00018475":"","S00018476":""}],

"Metabolites":[{"Metabolite":"2 or 3-phosphoglycerate","retention index":"","quantified m/z":"","PubChem ID":"724","KEGG ID":""},{"Metabolite":"6-phosphogluconate","retention index":"","quantified m/z":"","PubChem ID":"91493","KEGG ID":""},{"Metabolite":"acetyl-coa","retention index":"","quantified m/z":"","PubChem ID":"444493","KEGG ID":""},{"Metabolite":"adenosine diphosphate","retention index":"","quantified m/z":"","PubChem ID":"6022","KEGG ID":""},{"Metabolite":"adenosine monophosphate","retention index":"","quantified m/z":"","PubChem ID":"6083","KEGG ID":""},{"Metabolite":"adenosine triphosphate","retention index":"","quantified m/z":"","PubChem ID":"5957","KEGG ID":""},{"Metabolite":"citrate or isocitrate","retention index":"","quantified m/z":"","PubChem ID":"311","KEGG ID":""},{"Metabolite":"erythrose 4-phosphate","retention index":"","quantified m/z":"","PubChem ID":"122357","KEGG ID":""},{"Metabolite":"glucose 6-phosphate or fructose-6-phosphate","retention index":"","quantified m/z":"","PubChem ID":"5958","KEGG ID":""},{"Metabolite":"flavin adenine dinucleotide","retention index":"","quantified m/z":"","PubChem ID":"46906035","KEGG ID":""},{"Metabolite":"fructose 1,6-bisphosphate","retention index":"","quantified m/z":"","PubChem ID":"21125049","KEGG ID":""},{"Metabolite":"malate","retention index":"","quantified m/z":"","PubChem ID":"525","KEGG ID":""},{"Metabolite":"nicotinamide adenine dinucleotide oxidized","retention index":"","quantified m/z":"","PubChem ID":"15938971","KEGG ID":""},{"Metabolite":"nicotinamide adenine dinucleotide reduced","retention index":"","quantified m/z":"","PubChem ID":"439153","KEGG ID":""},{"Metabolite":"nicotinamide adenine dinucleotide phosphate oxidized","retention index":"","quantified m/z":"","PubChem ID":"15938972","KEGG ID":""},{"Metabolite":"nicotinamide adenine dinucleotide phosphate reduced","retention index":"","quantified m/z":"","PubChem ID":"22833512","KEGG ID":""},{"Metabolite":"phosphoenolpyruvate","retention index":"","quantified m/z":"","PubChem ID":"1005","KEGG ID":""},{"Metabolite":"ribose-5-phosphate or xylulose 5-phosphate","retention index":"","quantified m/z":"","PubChem ID":"77982","KEGG ID":""},{"Metabolite":"sedoheptulose 7-phosphate","retention index":"","quantified m/z":"","PubChem ID":"165007","KEGG ID":""},{"Metabolite":"sucrose","retention index":"","quantified m/z":"","PubChem ID":"5988","KEGG ID":""}]
}

}