{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000443","ANALYSIS_ID":"AN000694","VERSION":"1","CREATED_ON":"August 5, 2016, 10:26 am"},

"PROJECT":{"PROJECT_TITLE":"Impact of Long-Term Poor and Good Glycemic Control on Metabolomics Alterations in Type 1 Diabetic People.","PROJECT_TYPE":"Targeted GC-MS of plasma levels of tricarboxylic acid (TCA) cycle metabolites","PROJECT_SUMMARY":"The objective of the study was to determine whether T1D with good glycemic control have persistent abnormalities of metabolites and pathways that exist in T1D with poor glycemic control.","INSTITUTE":"Mayo Clinic","DEPARTMENT":"Endocrinology","LABORATORY":"Mayo Clinic Metabolomics Resource Core","LAST_NAME":"Nair","FIRST_NAME":"Sreekumaran","ADDRESS":"200 First Street SW, Rochester, MN 55905","EMAIL":"Nair.K@mayo.edu","PHONE":"507-285-2415"},

"STUDY":{"STUDY_TITLE":"Quantitative measurements of TCA cycle metabolites in T1D poor control, good control, and controls.","STUDY_TYPE":"Quantitative measurements of plasma levels of tricarboxylic acid (TCA) cycle metabolites","STUDY_SUMMARY":"The objective of the study was to determine whether T1D with good glycemic control have persistent abnormalities of metabolites and pathways that exist in T1D with poor glycemic control.","INSTITUTE":"Mayo Clinic","DEPARTMENT":"Endocrinology","LABORATORY":"Mayo Clinic Metabolomics Resource Core","LAST_NAME":"Nair","FIRST_NAME":"Sreekumaran","ADDRESS":"200 First Street SW, Rochester, MN 55905","EMAIL":"Nair.K@mayo.edu","PHONE":"507-285-2415"},

"SUBJECT":{"SUBJECT_TYPE":"Animal","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"ms3332-1",
"Sample ID":"sample1",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-2",
"Sample ID":"sample2",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-3",
"Sample ID":"sample3",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-4",
"Sample ID":"sample4",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-5",
"Sample ID":"sample5",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-6",
"Sample ID":"sample6",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-7",
"Sample ID":"sample7",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-8",
"Sample ID":"sample8",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-9",
"Sample ID":"sample9",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-10",
"Sample ID":"sample10",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-19",
"Sample ID":"sample11",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-20",
"Sample ID":"sample12",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-21",
"Sample ID":"sample13",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-22",
"Sample ID":"sample14",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-23",
"Sample ID":"sample15",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-20",
"Sample ID":"sample16",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-11",
"Sample ID":"sample17",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-12",
"Sample ID":"sample18",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-13",
"Sample ID":"sample19",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-14",
"Sample ID":"sample20",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-15",
"Sample ID":"sample21",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-16",
"Sample ID":"sample22",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-24",
"Sample ID":"sample23",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-25",
"Sample ID":"sample24",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-26",
"Sample ID":"sample25",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-16",
"Sample ID":"sample26",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-17",
"Sample ID":"sample27",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-18",
"Sample ID":"sample28",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-27",
"Sample ID":"sample29",
"Factors":{"treatment":"T1D good glycemic control"}
},
{
"Subject ID":"ms3332-28",
"Sample ID":"sample30",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3333-25",
"Sample ID":"sample31",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3333-14",
"Sample ID":"sample32",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3333-27",
"Sample ID":"sample33",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3333-4",
"Sample ID":"sample34",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3333-6",
"Sample ID":"sample35",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-36",
"Sample ID":"sample36",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-50",
"Sample ID":"sample37",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3333-20",
"Sample ID":"sample38",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-28",
"Sample ID":"sample39",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3333-8",
"Sample ID":"sample40",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-14",
"Sample ID":"sample41",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3333-10",
"Sample ID":"sample42",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3333-12",
"Sample ID":"sample43",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3332-54",
"Sample ID":"sample44",
"Factors":{"treatment":"ND"}
},
{
"Subject ID":"ms3333-1",
"Sample ID":"sample45",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-21",
"Sample ID":"sample46",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-7",
"Sample ID":"sample47",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-22",
"Sample ID":"sample48",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-9",
"Sample ID":"sample49",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-11",
"Sample ID":"sample50",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-23",
"Sample ID":"sample51",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-13",
"Sample ID":"sample52",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-15",
"Sample ID":"sample53",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-3",
"Sample ID":"sample54",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-5",
"Sample ID":"sample55",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-16",
"Sample ID":"sample56",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-18",
"Sample ID":"sample57",
"Factors":{"treatment":"T1D poor glycemic control"}
},
{
"Subject ID":"ms3333-19",
"Sample ID":"sample58",
"Factors":{"treatment":"T1D poor glycemic control"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"At 5:00 AM after an overnight fast, baseline blood samples were collected from study participants. Plasma samples were stored at 80°C until analysis.","SAMPLE_TYPE":"Blood. Plasma was isolated for MS analysis."},

"TREATMENT":{"TREATMENT_SUMMARY":"Participants were admitted to the Clinical Research Unit at St Mary’s Hospital (Rochester, Minnesota) the evening before the study and spent overnight in the Clinical Research Unit. The participants were given a standard meal on the evening of the admission after which they fasted overnight. Participants with T1D were treated with insulin as per their usual individual programs. At 5:00 AM after an overnight fast, baseline blood samples were collected from study participants. Plasma samples were stored at 80°C until analysis."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Plasma quality-control samples used in the study were prepared from pooled plasma spiked with a selection of metabolites to mimic elevated levels of metabolites during I− (insulin withdrawn) condition. Plasma was spiked with a standard mixture (3:1 ratio of plasma to spiking solution) containing 100 μg/mL niacin, hypoxanthine, leucine, isoleucine, phenylalanine, tryptophan, citric acid, glucose, hippuric acid, and taurocholic acid dissolved in 1:1 acetonitrile/water. All plasma samples (200 μL) were thawed on ice at 4°C followed by deproteinization with methanol (1:4 ratio of plasma to methanol) and vortexed for 10 s, followed by incubation at −20°C for 2 h. The samples were then centrifuged at 15,871g for 30 min at 4°C. The supernatants were lyophilized (Savant, Holbrook, NY) and stored at −20°C prior to analysis. The samples were reconstituted in 50% H2O/acetonitrile and passed through a Microcon YM3 filter (Millipore Corporation). The supernatants were transferred to analytical vials, stored in the autosampler at 4°C, and analyzed within 48 h of reconstitution in buffer."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"The derivatized extracts were analyzed with an Agilent 6890 gas chromatograph coupled with an Agilent 5973 mass selective detector. The 1-μL aliquots of the extracts were injected into a DB5-MS capillary column (30 m × 250 μm i.d., 0.25-μm film thickness; J&W Scientific, Folson, CA) using PTV injection (Gerstel CIS4 injector) in the splitless mode. The temperature of the PTV was 70 °C during injection, and 0.6 min after injection, the temperature was raised to 300 °C at a rate of 2 °C/s and held at 300 °C for 20 min. The initial GC oven temperature was 70 °C, 5 min after injection the GC oven temperature was increased with 5 °C/min to 320 °C and held for 5 min at 320 °C. Helium was used as a carrier gas and pressure programmed such that the helium flow was kept constant at a flow rate of 1.7 mL/min. Detection was achieved using MS detection in electron impact mode and full scan monitoring mode (m/z 15−800). The temperature of the ion source was set at 250 °C and that of the quadrupole at 200 °C.","CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"Agilent 6890","COLUMN_NAME":"None"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Agilent 5973","INSTRUMENT_TYPE":"Single quadrupole","MS_TYPE":"EI","ION_MODE":"POSITIVE"},

"MS_METABOLITE_DATA":{
"Units":"micromolar",

"Data":[{"Metabolite":"Citrate","sample1":"129.409","sample2":"151.45","sample3":"132.09","sample4":"160.582","sample5":"139.822","sample6":"240.655","sample7":"150.787","sample8":"161.508","sample9":"206.101","sample10":"111.822","sample11":"151.149","sample12":"161.742","sample13":"121.657","sample14":"128.015","sample15":"212.104","sample16":"161.439","sample17":"140.06","sample18":"155.595","sample19":"154.462","sample20":"137.393","sample21":"97.643","sample22":"154.683","sample23":"156.613","sample24":"146.307","sample25":"159.329","sample26":"153.502","sample27":"128.017","sample28":"158.248","sample29":"169.83","sample30":"121.615","sample31":"165.4","sample32":"134.54","sample33":"101.11","sample34":"182.76","sample35":"146.54","sample36":"151.19","sample37":"135.915","sample38":"120.29","sample39":"121.44","sample40":"160.7","sample41":"138.44","sample42":"151","sample43":"143.61","sample44":"176.203","sample45":"140.49","sample46":"146.08","sample47":"145.09","sample48":"146.63","sample49":"143.91","sample50":"106.71","sample51":"137.517","sample52":"139.24","sample53":"120.96","sample54":"125.09","sample55":"171.23","sample56":"130.4","sample57":"111.603","sample58":"106.19"},{"Metabolite":"cis.Aconitate","sample1":"7.016","sample2":"6.715","sample3":"8.198","sample4":"6.811","sample5":"8.733","sample6":"8.616","sample7":"8.088","sample8":"7.312","sample9":"10.19","sample10":"6.864","sample11":"9.68","sample12":"11.902","sample13":"11.789","sample14":"8.937","sample15":"11.614","sample16":"12.388","sample17":"9.276","sample18":"9.012","sample19":"10.06","sample20":"8.776","sample21":"9.095","sample22":"9.349","sample23":"10.314","sample24":"9.595","sample25":"9.435","sample26":"9.371","sample27":"9.847","sample28":"8.88","sample29":"12.047","sample30":"10.757","sample31":"NA","sample32":"9.71","sample33":"8.35","sample34":"8.23","sample35":"8.49","sample36":"7.71","sample37":"3.824","sample38":"8.37","sample39":"7.61","sample40":"9.43","sample41":"8.84","sample42":"9.69","sample43":"8.93","sample44":"4.636","sample45":"8.26","sample46":"8.81","sample47":"7.22","sample48":"9.26","sample49":"9.95","sample50":"9.46","sample51":"4.447","sample52":"8.01","sample53":"9.4","sample54":"8.89","sample55":"11.61","sample56":"6.42","sample57":"4.853","sample58":"8.53"},{"Metabolite":"Isocitrate","sample1":"5.174","sample2":"4.823","sample3":"3.193","sample4":"4.693","sample5":"3.529","sample6":"8.331","sample7":"5.241","sample8":"6.378","sample9":"6.651","sample10":"5.752","sample11":"2.368","sample12":"5.993","sample13":"1.16","sample14":"5.479","sample15":"9.255","sample16":"6.631","sample17":"6.755","sample18":"6.608","sample19":"5.65","sample20":"7.009","sample21":"NA","sample22":"3.999","sample23":"5.607","sample24":"2.916","sample25":"4.518","sample26":"6.191","sample27":"4.886","sample28":"5.016","sample29":"NA","sample30":"5.537","sample31":"5.37","sample32":"5.39","sample33":"3.81","sample34":"5.85","sample35":"6.1","sample36":"4.66","sample37":"5.568","sample38":"3.71","sample39":"6.2","sample40":"6.81","sample41":"6.75","sample42":"6.08","sample43":"5.79","sample44":"6.512","sample45":"4.26","sample46":"5.89","sample47":"6.07","sample48":"4.53","sample49":"1.98","sample50":"5.48","sample51":"5.69","sample52":"7.85","sample53":"1.56","sample54":"2.28","sample55":"4.65","sample56":"1.51","sample57":"3.653","sample58":"2.56"},{"Metabolite":"Ketoglutarate","sample1":"17.043","sample2":"7.759","sample3":"9.32","sample4":"8.77","sample5":"12.235","sample6":"14.028","sample7":"10.882","sample8":"13.581","sample9":"13.709","sample10":"7.695","sample11":"12.939","sample12":"15.085","sample13":"9.809","sample14":"12.485","sample15":"11.337","sample16":"15.079","sample17":"8.577","sample18":"12.148","sample19":"12.049","sample20":"10.911","sample21":"10.316","sample22":"14.67","sample23":"21.656","sample24":"10.782","sample25":"11.113","sample26":"14.517","sample27":"11.444","sample28":"13.338","sample29":"12.055","sample30":"9.916","sample31":"8.65","sample32":"8.25","sample33":"11.11","sample34":"11.4","sample35":"9.77","sample36":"13.78","sample37":"9.407","sample38":"12.68","sample39":"9.93","sample40":"9.19","sample41":"10.91","sample42":"9.69","sample43":"9.96","sample44":"10.064","sample45":"10.56","sample46":"12.71","sample47":"10.59","sample48":"8.67","sample49":"13.38","sample50":"11.06","sample51":"9.434","sample52":"13.44","sample53":"11.26","sample54":"9.7","sample55":"13.28","sample56":"12.43","sample57":"7.275","sample58":"8.7"},{"Metabolite":"succinate","sample1":"4.163","sample2":"2.579","sample3":"2.817","sample4":"2.607","sample5":"3.253","sample6":"4.951","sample7":"3.258","sample8":"3.821","sample9":"3.809","sample10":"2.495","sample11":"3.749","sample12":"4.896","sample13":"4.6","sample14":"3.405","sample15":"4.523","sample16":"4.874","sample17":"2.616","sample18":"3.459","sample19":"3.437","sample20":"2.896","sample21":"2.739","sample22":"5.719","sample23":"4.683","sample24":"3.454","sample25":"4.082","sample26":"5.88","sample27":"4.388","sample28":"5.7","sample29":"5.643","sample30":"3.055","sample31":"4.59","sample32":"2.43","sample33":"5.14","sample34":"4.08","sample35":"2.82","sample36":"5.26","sample37":"3.773","sample38":"4.12","sample39":"NA","sample40":"3.08","sample41":"2.94","sample42":"3.25","sample43":"2.72","sample44":"4.711","sample45":"3.84","sample46":"5.18","sample47":"3.72","sample48":"4.61","sample49":"4.03","sample50":"3.74","sample51":"1.802","sample52":"3.28","sample53":"4.66","sample54":"3.21","sample55":"4.14","sample56":"4.54","sample57":"1.17","sample58":"3.91"},{"Metabolite":"fummarate","sample1":"1.927","sample2":"0.997","sample3":"1.553","sample4":"1.046","sample5":"1.445","sample6":"2.322","sample7":"1.728","sample8":"1.753","sample9":"1.834","sample10":"1.174","sample11":"2.099","sample12":"2.54","sample13":"1.837","sample14":"1.738","sample15":"2.468","sample16":"2.561","sample17":"1.47","sample18":"1.737","sample19":"1.762","sample20":"2.033","sample21":"1.394","sample22":"2.908","sample23":"3.674","sample24":"1.954","sample25":"2.231","sample26":"2.98","sample27":"2.133","sample28":"3.127","sample29":"2.214","sample30":"2.172","sample31":"1.77","sample32":"1.21","sample33":"2.09","sample34":"2.21","sample35":"1.2","sample36":"1.78","sample37":"1.518","sample38":"2.78","sample39":"1.49","sample40":"2.04","sample41":"2.11","sample42":"1.63","sample43":"1.72","sample44":"2.429","sample45":"1.32","sample46":"2.15","sample47":"1.49","sample48":"2.04","sample49":"2.18","sample50":"2.04","sample51":"1.288","sample52":"1.81","sample53":"1.8","sample54":"1.38","sample55":"1.81","sample56":"1.94","sample57":"0.929","sample58":"1.59"},{"Metabolite":"Malate","sample1":"4.83","sample2":"2.246","sample3":"4.431","sample4":"2.865","sample5":"3.739","sample6":"7.132","sample7":"4.769","sample8":"4.479","sample9":"4.598","sample10":"2.52","sample11":"3.831","sample12":"4.183","sample13":"3.627","sample14":"3.35","sample15":"6.496","sample16":"4.154","sample17":"4.136","sample18":"3.927","sample19":"4.839","sample20":"4.02","sample21":"2.469","sample22":"5.412","sample23":"6.337","sample24":"3.521","sample25":"4.308","sample26":"5.365","sample27":"4.661","sample28":"5.004","sample29":"4.339","sample30":"3.083","sample31":"4.39","sample32":"2.09","sample33":"4.56","sample34":"4.68","sample35":"2.55","sample36":"3.84","sample37":"2.683","sample38":"6.23","sample39":"3.16","sample40":"4.42","sample41":"3.98","sample42":"3.67","sample43":"3.84","sample44":"8.92","sample45":"3.61","sample46":"4.79","sample47":"4.2","sample48":"3.45","sample49":"4.74","sample50":"3.51","sample51":"2.603","sample52":"4.43","sample53":"4.51","sample54":"3.5","sample55":"5.56","sample56":"3.54","sample57":"2.74","sample58":"2.41"},{"Metabolite":"Oxaloacetate","sample1":"0.988","sample2":"0.685","sample3":"0.638","sample4":"0.449","sample5":"1.094","sample6":"0.198","sample7":"0.471","sample8":"1.539","sample9":"0.455","sample10":"0.862","sample11":"1.306","sample12":"1.434","sample13":"1.372","sample14":"1.562","sample15":"1.494","sample16":"1.417","sample17":"0.832","sample18":"0.541","sample19":"0.673","sample20":"0.764","sample21":"1.139","sample22":"1.04","sample23":"1.437","sample24":"1.334","sample25":"1.406","sample26":"1.602","sample27":"1.425","sample28":"1.774","sample29":"1.439","sample30":"1.448","sample31":"NA","sample32":"0.63","sample33":"1.27","sample34":"2.19","sample35":"0.74","sample36":"1.28","sample37":"0.357","sample38":"1.42","sample39":"1.45","sample40":"1.31","sample41":"0.79","sample42":"2.22","sample43":"0.98","sample44":"0.655","sample45":"0.78","sample46":"1.41","sample47":"1.54","sample48":"1.26","sample49":"0.39","sample50":"1.38","sample51":"1.033","sample52":"0.73","sample53":"1.38","sample54":"0.85","sample55":"0.87","sample56":"1.51","sample57":"0.988","sample58":"1.26"},{"Metabolite":"Aspartate","sample1":"0.426","sample2":"0.882","sample3":"2.113","sample4":"0.291","sample5":"1.509","sample6":"0.24","sample7":"0.832","sample8":"2.505","sample9":"0.157","sample10":"1.076","sample11":"1.518","sample12":"1.743","sample13":"2.61","sample14":"0.924","sample15":"0.969","sample16":"1.718","sample17":"2.751","sample18":"0.731","sample19":"2.614","sample20":"1.378","sample21":"1.893","sample22":"2.393","sample23":"1.21","sample24":"1.313","sample25":"1.546","sample26":"2.34","sample27":"2.617","sample28":"1.173","sample29":"0.648","sample30":"1.544","sample31":"NA","sample32":"0.79","sample33":"0.81","sample34":"1.25","sample35":"0.92","sample36":"0.76","sample37":"0.69","sample38":"1.22","sample39":"1.55","sample40":"2.18","sample41":"1.43","sample42":"0.79","sample43":"0.91","sample44":"1.303","sample45":"3.66","sample46":"1.1","sample47":"1.25","sample48":"2.06","sample49":"1.57","sample50":"1.71","sample51":"1.364","sample52":"1.33","sample53":"1.41","sample54":"1.88","sample55":"1.11","sample56":"1","sample57":"0.54","sample58":"1.26"},{"Metabolite":"Glutamate","sample1":"119.374","sample2":"86.447","sample3":"118.767","sample4":"74.218","sample5":"120.377","sample6":"23.964","sample7":"39.453","sample8":"369.402","sample9":"31.138","sample10":"133.69","sample11":"288.466","sample12":"261.847","sample13":"234.399","sample14":"155.741","sample15":"99.413","sample16":"273.395","sample17":"195.569","sample18":"157.737","sample19":"180.506","sample20":"170.106","sample21":"435.011","sample22":"332.078","sample23":"422.406","sample24":"346.439","sample25":"300.114","sample26":"382.792","sample27":"214.579","sample28":"234.834","sample29":"60.201","sample30":"593.966","sample31":"NA","sample32":"212.32","sample33":"58.94","sample34":"76.25","sample35":"124.62","sample36":"85.99","sample37":"56.348","sample38":"133.94","sample39":"402.74","sample40":"341.29","sample41":"180.65","sample42":"156.21","sample43":"247.71","sample44":"127.927","sample45":"273.56","sample46":"123.93","sample47":"305.62","sample48":"257.66","sample49":"182.52","sample50":"263.24","sample51":"241.339","sample52":"135.19","sample53":"166.74","sample54":"273.12","sample55":"131.69","sample56":"71.24","sample57":"98.966","sample58":"280.48"},{"Metabolite":"Lacatate","sample1":"80.199","sample2":"59.895","sample3":"27.472","sample4":"73.667","sample5":"44.132","sample6":"70.29","sample7":"50.013","sample8":"85.155","sample9":"56.179","sample10":"64.61","sample11":"172.298","sample12":"133.209","sample13":"72.363","sample14":"114.601","sample15":"127.77","sample16":"134.176","sample17":"53.29","sample18":"99.514","sample19":"208.27","sample20":"44.562","sample21":"98.247","sample22":"NA","sample23":"83.018","sample24":"121.839","sample25":"71.672","sample26":"NA","sample27":"88.389","sample28":"17.251","sample29":"120.304","sample30":"162.041","sample31":"82.6","sample32":"97.11","sample33":"247.64","sample34":"188.32","sample35":"152.55","sample36":"123.54","sample37":"102.913","sample38":"NA","sample39":"171.37","sample40":"63.66","sample41":"47.18","sample42":"52.41","sample43":"61.51","sample44":"212.425","sample45":"49.99","sample46":"188.48","sample47":"42.37","sample48":"62.51","sample49":"90.09","sample50":"126.8","sample51":"77.364","sample52":"123.04","sample53":"133.02","sample54":"47.79","sample55":"156.93","sample56":"103.32","sample57":"80.37","sample58":"51.88"},{"Metabolite":"Alanine","sample1":"383.673","sample2":"356.072","sample3":"399.334","sample4":"385.052","sample5":"405.646","sample6":"434.298","sample7":"357.49","sample8":"440.415","sample9":"381.397","sample10":"311.723","sample11":"386.988","sample12":"392.706","sample13":"333.001","sample14":"347.981","sample15":"432.635","sample16":"393.753","sample17":"419.033","sample18":"428.607","sample19":"383.098","sample20":"398.638","sample21":"385.287","sample22":"422.021","sample23":"314.328","sample24":"375.073","sample25":"380.41","sample26":"428.762","sample27":"345.497","sample28":"353.356","sample29":"348.808","sample30":"416.794","sample31":"68.74","sample32":"431.45","sample33":"395.21","sample34":"465.32","sample35":"410.93","sample36":"399.83","sample37":"362.082","sample38":"427.84","sample39":"420.21","sample40":"376.5","sample41":"408.15","sample42":"371.21","sample43":"316.97","sample44":"384.216","sample45":"389.61","sample46":"413.54","sample47":"372.58","sample48":"373.2","sample49":"439.15","sample50":"430.95","sample51":"359.997","sample52":"453.24","sample53":"440.81","sample54":"350.66","sample55":"457.72","sample56":"355.98","sample57":"251.086","sample58":"331.75"}],

"Metabolites":[{"metabolite_name":"Citrate"},{"metabolite_name":"cis.Aconitate"},{"metabolite_name":"Isocitrate"},{"metabolite_name":"Ketoglutarate"},{"metabolite_name":"succinate"},{"metabolite_name":"fummarate"},{"metabolite_name":"Malate"},{"metabolite_name":"Oxaloacetate"},{"metabolite_name":"Aspartate"},{"metabolite_name":"Glutamate"},{"metabolite_name":"Lacatate"},{"metabolite_name":"Alanine"}]
}

}