{
"METABOLOMICS WORKBENCH":{"VERSION":"1","CREATED_ON":"November 16, 2016, 3:04 pm"},

"PROJECT":{"PROJECT_TITLE":"Mayo Metabolomics Pilot and Feasibility Award: Mechanisms of sleep apnea and cardiovascular disease","PROJECT_TYPE":"MS targeted analysis","PROJECT_SUMMARY":"Targeted Metabolic and Biological Markers of Sleepiness Symptoms in Sleep apnea and cardiovascular disease","INSTITUTE":"Mayo Clinic","LABORATORY":"Mayo Clinic Metabolomics Resource Core","LAST_NAME":"Pak","FIRST_NAME":"Victoria","ADDRESS":"unknown","EMAIL":"victoria.pak@yale.edu","PHONE":"203-737-5065"},

"STUDY":{"STUDY_TITLE":"Sleep apnea and cardiovascular samples amino acid metabolites","STUDY_SUMMARY":"Sleep apnea and cardiovascular samples amino acid metabolites","INSTITUTE":"Mayo Clinic","LABORATORY":"Mayo Clinic Metabolomics Resource Core","LAST_NAME":"Pak","FIRST_NAME":"Victoria","ADDRESS":"unknown","EMAIL":"victoria.pak@yale.edu","PHONE":"203-737-5065"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"s_01",
"Sample ID":"ms5686-1",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_02",
"Sample ID":"ms5686-2",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_03",
"Sample ID":"ms5686-3",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_04",
"Sample ID":"ms5686-4",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_05",
"Sample ID":"ms5686-5",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_06",
"Sample ID":"ms5686-6",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_07",
"Sample ID":"ms5686-7",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_08",
"Sample ID":"ms5686-8",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_09",
"Sample ID":"ms5686-9",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_10",
"Sample ID":"ms5686-10",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_11",
"Sample ID":"ms5686-11",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_12",
"Sample ID":"ms5686-12",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_13",
"Sample ID":"ms5686-13",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_14",
"Sample ID":"ms5686-14",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_15",
"Sample ID":"ms5686-15",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_16",
"Sample ID":"ms5686-16",
"Factors":{"Disease":"cardiovascular disease"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_17",
"Sample ID":"ms5686-17",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_18",
"Sample ID":"ms5686-18",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_19",
"Sample ID":"ms5686-19",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_20",
"Sample ID":"ms5686-20",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_21",
"Sample ID":"ms5686-21",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_22",
"Sample ID":"ms5686-22",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_23",
"Sample ID":"ms5686-23",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_24",
"Sample ID":"ms5686-24",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_25",
"Sample ID":"ms5686-25",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_26",
"Sample ID":"ms5686-26",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_27",
"Sample ID":"ms5686-27",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_28",
"Sample ID":"ms5686-28",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_29",
"Sample ID":"ms5686-29",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_30",
"Sample ID":"ms5686-30",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_31",
"Sample ID":"ms5686-31",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_32",
"Sample ID":"ms5686-32",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_33",
"Sample ID":"ms5686-33",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_34",
"Sample ID":"ms5686-34",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_35",
"Sample ID":"ms5686-35",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
},
{
"Subject ID":"s_36",
"Sample ID":"ms5686-36",
"Factors":{"Disease":"sleep apnea"},
"Additional sample data":{"sample type":"plasma","Assay":"Concentration of AA  + metabolites in plasma"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"For the metabolic markers, 9 ml blood will be drawn into 3 EDTA tubes (3 ml each) and gently centrifuged at 4°C for 10 min; plasma aliquots were immediately frozen and stored at -80 °C; will be stored at -80ºC in the CTRC until all samples are collected and then sent to Mayo Clinic Metabolomics Core via LC-MS/MS for simultaneous detection and quantification of metabolites for analyses."},

"TREATMENT":{"TREATMENT_SUMMARY":"Recruitment of subjects will take place from the clinic population in collaboration with the Penn Sleep Center. Patients newly diagnosed with OSA will be solicited for via an overnight sleep study, which is general monitoring of sleep and variety of body functions during sleep. This includes brain (EEG), eye (EOG), and muscle activity and heart rhythm. The diagnosis of OSA will be established by full sleep study. First, the PI will screen for eligibility and obtain informed consent. We will assess height, weight, medical history, demographics. EDS will be measured subjectively on the night of enrollment in the study and determined using the Epworth Sleepiness Scale. The information regarding gender, BMI, smoking, age, medications (name/duration/frequency), and presence of comorbidities (e.g. hypertension, CVD defined by doctor diagnosis of myocardial infarction, stroke, or heart failure) will then be obtained via the electronic medical record. We will also ask subjects whether they exercise by asking participants the yes/no question: “During the past month, did you participate in any physical activities or exercises?” Second, the subject will undergo diagnostic PSG and we will enforce fasting prior to bedtime. Third, biological samples will be collected in the morning after the sleep study. Patients who have agreed to participate will undergo a blood draw (20 ml) and urine collection (30 ml) on the morning after PSG. Laboratory analysis of the biological samples will be conducted in collaboration with the Clinical Translation Research Center (CTRC). Finally, subjects will have 1 or 2 practice sessions with the PVT prior to administration of the task. PVT test will be conducted 3 times, at approximately 10:00, 12:00, and 14:00 and automatically scored. This will be done on the day after the sleep study."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Amino Acid Panel"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Waters Acquity","COLUMN_NAME":"Waters Acquity BEH C18 (150 x 2.1mm, 1.7um)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Thermo Quantum Ultra","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","ION_MODE":"POSITIVE"},

"MS_METABOLITE_DATA":{
"Units":"micromolar",

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"Metabolites":[{"metabolite_name":"Histidine"},{"metabolite_name":"Hydroxyproline"},{"metabolite_name":"1-Methylhistidine"},{"metabolite_name":"3-Methylhistidine"},{"metabolite_name":"Phosphoethanolamine"},{"metabolite_name":"Carnosine"},{"metabolite_name":"Anserine"},{"metabolite_name":"Ethanolamine"},{"metabolite_name":"Aspartic Acid"},{"metabolite_name":"Sarcosine"},{"metabolite_name":"beta-alanine"},{"metabolite_name":"gamma-Amino-N-butyric-acid"},{"metabolite_name":"alpha-Aminoadipic-acid"},{"metabolite_name":"beta-Aminoisobutyric-acid"},{"metabolite_name":"Hydroxylysine 1"},{"metabolite_name":"Hydroxylysine 2"},{"metabolite_name":"alpha-Amino-N-butyric-acid"},{"metabolite_name":"Cystathionine 1"},{"metabolite_name":"Cystathionine 2"},{"metabolite_name":"Methionine"},{"metabolite_name":"allo-Isoleucine"},{"metabolite_name":"Homocystine"},{"metabolite_name":"Asparagine"},{"metabolite_name":"Arginine"},{"metabolite_name":"Taurine"},{"metabolite_name":"Serine"},{"metabolite_name":"Glutamine"},{"metabolite_name":"Glycine"},{"metabolite_name":"Citrulline"},{"metabolite_name":"Glutamic Acid"},{"metabolite_name":"Threonine"},{"metabolite_name":"Alanine"},{"metabolite_name":"Proline"},{"metabolite_name":"Ornithine"},{"metabolite_name":"Lysine"},{"metabolite_name":"Cystine"},{"metabolite_name":"Tyrosine"},{"metabolite_name":"Valine"},{"metabolite_name":"Isoleucine"},{"metabolite_name":"Leucine"},{"metabolite_name":"Phenylalanine"},{"metabolite_name":"Tryptophan"}]
}

}