{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000601","ANALYSIS_ID":"AN000921","VERSION":"1","CREATED_ON":"May 9, 2017, 1:45 pm"},

"PROJECT":{"PROJECT_TITLE":"Chronic Obstructive Pulmonary Disease Human Plasma Metabolomics","PROJECT_TYPE":"Untargeted LC-MS Metabolomics","PROJECT_SUMMARY":"COPD is a very heterogeneous disease comprising multiple phenotypes. Plasma from 131 human subjects was collected as part of the NIH-sponsored COPDGene cohort and analyzed using untargeted LC-MS (C18+) and (HILIC+) metabolomics. The goal was to identify perturbed compounds and pathways associated with COPD.","INSTITUTE":"University of Colorado, Denver","DEPARTMENT":"Pharmaceutical Sciences, Anschutz Medical Campus","LAST_NAME":"Nichole","FIRST_NAME":"Reisdorph","ADDRESS":"12850 East Montview Blvd, Aurora, CO 80045","EMAIL":"Nichole.Reisdorph@ucdenver.edu","PHONE":"303-724-9243","FUNDING_SOURCE":"NIH P20"},

"STUDY":{"STUDY_TITLE":"Untargeted LC-MS metabolomics analysis of human COPD plasma, HILIC & C18","STUDY_SUMMARY":"Identify perturbed metabolites and pathways in human plasma collected from 131 COPD subjects. Subjects were either current or former smokers with various COPD phenotypes including emphysema, and exacerbations.","INSTITUTE":"University of Colorado Anschutz Medical Campus","LAST_NAME":"Reisdorph","FIRST_NAME":"Nichole","ADDRESS":"12850 East Montview Blvd, Aurora, CO 80045","EMAIL":"Nichole.Reisdorph@ucdenver.edu","PHONE":"303-724-9243","TOTAL_SUBJECTS":"131","NUM_MALES":"56","NUM_FEMALES":"75"},

"SUBJECT":{"SUBJECT_TYPE":"Human Plasma","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606","AGE_OR_AGE_RANGE":"57-70","GENDER":"Males and Females","HUMAN_RACE":"Non-Hispanic White","HUMAN_SMOKING_STATUS":"Current and Former Smokers"},
"SUBJECT_SAMPLE_FACTORS":[
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"Subject ID":"-",
"Sample ID":"10062C",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"64.6","Gender":"1","BMI":"27.71","FEV1/FVC":"0.46","FEV1 percent predicted":"36.6","BDR":"1","% Emphysema":"NA","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10071D",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"66.1","Gender":"1","BMI":"32.64","FEV1/FVC":"0.65","FEV1 percent predicted":"54","BDR":"-","% Emphysema":"4.0476","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10087S",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"65.5","Gender":"2","BMI":"26.58","FEV1/FVC":"0.49","FEV1 percent predicted":"52.7","BDR":"1","% Emphysema":"21.2527","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"10097V",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"75.7","Gender":"2","BMI":"23.62","FEV1/FVC":"0.43","FEV1 percent predicted":"31.7","BDR":"-","% Emphysema":"16.3921","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10102O",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"61.2","Gender":"1","BMI":"30.82","FEV1/FVC":"0.78","FEV1 percent predicted":"94","BDR":"-","% Emphysema":"1.5828","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10104S",
"Factors":{"Smoking Status":"1","Gold Stage":"-"},
"Additional sample data":{"Age":"50.6","Gender":"2","BMI":"26.87","FEV1/FVC":"0.76","FEV1 percent predicted":"95.7","BDR":"1","% Emphysema":"0.965","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10136F",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"60.6","Gender":"2","BMI":"24.4","FEV1/FVC":"0.71","FEV1 percent predicted":"100.9","BDR":"-","% Emphysema":"1.0879","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10138J",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"55.7","Gender":"2","BMI":"17.92","FEV1/FVC":"0.69","FEV1 percent predicted":"59.7","BDR":"NA","% Emphysema":"0.3687","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"10166O",
"Factors":{"Smoking Status":"-","Gold Stage":"1"},
"Additional sample data":{"Age":"46.2","Gender":"1","BMI":"26.01","FEV1/FVC":"0.66","FEV1 percent predicted":"84.2","BDR":"1","% Emphysema":"2.6603","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10170F",
"Factors":{"Smoking Status":"-","Gold Stage":"4"},
"Additional sample data":{"Age":"68.4","Gender":"1","BMI":"22.22","FEV1/FVC":"0.32","FEV1 percent predicted":"23.7","BDR":"1","% Emphysema":"15.3613","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10182M",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"65.3","Gender":"1","BMI":"37.33","FEV1/FVC":"0.46","FEV1 percent predicted":"36","BDR":"-","% Emphysema":"NA","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"10245K",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"66.4","Gender":"1","BMI":"25.22","FEV1/FVC":"0.39","FEV1 percent predicted":"54.9","BDR":"-","% Emphysema":"24.264","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10300S",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"71.3","Gender":"2","BMI":"29.11","FEV1/FVC":"0.42","FEV1 percent predicted":"38.8","BDR":"-","% Emphysema":"11.2753","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10328O",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"73.8","Gender":"1","BMI":"26.65","FEV1/FVC":"0.55","FEV1 percent predicted":"40.2","BDR":"-","% Emphysema":"17.5086","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10390T",
"Factors":{"Smoking Status":"1","Gold Stage":"4"},
"Additional sample data":{"Age":"73.1","Gender":"1","BMI":"17.32","FEV1/FVC":"0.34","FEV1 percent predicted":"29.3","BDR":"1","% Emphysema":"27.0944","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10455V",
"Factors":{"Smoking Status":"-","Gold Stage":"4"},
"Additional sample data":{"Age":"65.9","Gender":"1","BMI":"36.55","FEV1/FVC":"0.38","FEV1 percent predicted":"25.8","BDR":"-","% Emphysema":"2.1089","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10458B",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"70.5","Gender":"2","BMI":"23.23","FEV1/FVC":"0.37","FEV1 percent predicted":"31.6","BDR":"1","% Emphysema":"26.8499","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10465Y",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"72.5","Gender":"1","BMI":"21.41","FEV1/FVC":"0.79","FEV1 percent predicted":"103.9","BDR":"-","% Emphysema":"4.178","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10473X",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"66.3","Gender":"1","BMI":"30.7","FEV1/FVC":"0.61","FEV1 percent predicted":"52.1","BDR":"-","% Emphysema":"2.1597","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10544U",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"58.8","Gender":"1","BMI":"28.59","FEV1/FVC":"0.41","FEV1 percent predicted":"57.7","BDR":"NA","% Emphysema":"24.6265","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"10636Z",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"56.7","Gender":"2","BMI":"35.85","FEV1/FVC":"0.62","FEV1 percent predicted":"65.8","BDR":"1","% Emphysema":"3.4625","Exacerbation Frequency":"-"}
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{
"Subject ID":"-",
"Sample ID":"10687Q",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"71.4","Gender":"2","BMI":"22.83","FEV1/FVC":"0.79","FEV1 percent predicted":"98.1","BDR":"-","% Emphysema":"0.9173","Exacerbation Frequency":"5"}
},
{
"Subject ID":"-",
"Sample ID":"11070G",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"65.6","Gender":"1","BMI":"24.28","FEV1/FVC":"0.31","FEV1 percent predicted":"32.1","BDR":"-","% Emphysema":"11.6625","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"11218M",
"Factors":{"Smoking Status":"-","Gold Stage":"4"},
"Additional sample data":{"Age":"71.9","Gender":"1","BMI":"38.56","FEV1/FVC":"0.33","FEV1 percent predicted":"25","BDR":"1","% Emphysema":"17.1307","Exacerbation Frequency":"5"}
},
{
"Subject ID":"-",
"Sample ID":"12593R",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"52","Gender":"1","BMI":"27.78","FEV1/FVC":"0.5","FEV1 percent predicted":"74.5","BDR":"-","% Emphysema":"5.398","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"12771P",
"Factors":{"Smoking Status":"1","Gold Stage":"-"},
"Additional sample data":{"Age":"48.2","Gender":"1","BMI":"26.17","FEV1/FVC":"0.76","FEV1 percent predicted":"88.9","BDR":"-","% Emphysema":"0.7622","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"12778D",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"75.2","Gender":"1","BMI":"26.31","FEV1/FVC":"0.39","FEV1 percent predicted":"43.9","BDR":"-","% Emphysema":"NA","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"12900A",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"51.7","Gender":"2","BMI":"32.95","FEV1/FVC":"0.59","FEV1 percent predicted":"60.9","BDR":"-","% Emphysema":"5.3201","Exacerbation Frequency":"1"}
},
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"Subject ID":"-",
"Sample ID":"12969K",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"78.4","Gender":"1","BMI":"34.52","FEV1/FVC":"0.72","FEV1 percent predicted":"88.2","BDR":"-","% Emphysema":"2.2313","Exacerbation Frequency":"-"}
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"Subject ID":"-",
"Sample ID":"13012C",
"Factors":{"Smoking Status":"-","Gold Stage":"4"},
"Additional sample data":{"Age":"54.1","Gender":"2","BMI":"30.72","FEV1/FVC":"0.23","FEV1 percent predicted":"23.9","BDR":"-","% Emphysema":"32.1305","Exacerbation Frequency":"3"}
},
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"Subject ID":"-",
"Sample ID":"13686D",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"77.6","Gender":"1","BMI":"20.31","FEV1/FVC":"0.35","FEV1 percent predicted":"45.8","BDR":"1","% Emphysema":"25.434","Exacerbation Frequency":"1"}
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"Subject ID":"-",
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"Factors":{"Smoking Status":"-","Gold Stage":"4"},
"Additional sample data":{"Age":"62","Gender":"2","BMI":"26.72","FEV1/FVC":"0.29","FEV1 percent predicted":"22.1","BDR":"1","% Emphysema":"16.5458","Exacerbation Frequency":"-"}
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"Subject ID":"-",
"Sample ID":"13959M",
"Factors":{"Smoking Status":"1","Gold Stage":"4"},
"Additional sample data":{"Age":"58.7","Gender":"1","BMI":"25.64","FEV1/FVC":"0.32","FEV1 percent predicted":"29.2","BDR":"1","% Emphysema":"8.5183","Exacerbation Frequency":"-"}
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"Subject ID":"-",
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"Factors":{"Smoking Status":"-","Gold Stage":"4"},
"Additional sample data":{"Age":"60.4","Gender":"1","BMI":"23.36","FEV1/FVC":"0.35","FEV1 percent predicted":"19.7","BDR":"1","% Emphysema":"25.6906","Exacerbation Frequency":"1"}
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"Subject ID":"-",
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"Additional sample data":{"Age":"54.2","Gender":"1","BMI":"29.62","FEV1/FVC":"0.65","FEV1 percent predicted":"55.6","BDR":"-","% Emphysema":"5.9311","Exacerbation Frequency":"-"}
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"Subject ID":"-",
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"Additional sample data":{"Age":"68.3","Gender":"2","BMI":"29.67","FEV1/FVC":"0.44","FEV1 percent predicted":"42.3","BDR":"-","% Emphysema":"18.9562","Exacerbation Frequency":"-"}
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"Additional sample data":{"Age":"59.8","Gender":"2","BMI":"33.73","FEV1/FVC":"0.66","FEV1 percent predicted":"74.8","BDR":"-","% Emphysema":"0.2194","Exacerbation Frequency":"2"}
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"Subject ID":"-",
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"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"75.1","Gender":"2","BMI":"21.42","FEV1/FVC":"0.44","FEV1 percent predicted":"46","BDR":"-","% Emphysema":"30.6821","Exacerbation Frequency":"-"}
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"Subject ID":"-",
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"Subject ID":"-",
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"Additional sample data":{"Age":"52.4","Gender":"2","BMI":"40.57","FEV1/FVC":"0.68","FEV1 percent predicted":"58.7","BDR":"-","% Emphysema":"0.2529","Exacerbation Frequency":"-"}
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"Additional sample data":{"Age":"52","Gender":"1","BMI":"36.09","FEV1/FVC":"0.66","FEV1 percent predicted":"66.1","BDR":"-","% Emphysema":"3.7679","Exacerbation Frequency":"4"}
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"Subject ID":"-",
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"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"71","Gender":"2","BMI":"40.48","FEV1/FVC":"0.56","FEV1 percent predicted":"47.5","BDR":"-","% Emphysema":"1.3905","Exacerbation Frequency":"1"}
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"Subject ID":"-",
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"Additional sample data":{"Age":"60.2","Gender":"1","BMI":"28.18","FEV1/FVC":"0.24","FEV1 percent predicted":"38.9","BDR":"1","% Emphysema":"19.2664","Exacerbation Frequency":"-"}
},
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"Subject ID":"-",
"Sample ID":"21609H",
"Factors":{"Smoking Status":"1","Gold Stage":"3"},
"Additional sample data":{"Age":"68","Gender":"1","BMI":"24.68","FEV1/FVC":"0.46","FEV1 percent predicted":"45.8","BDR":"-","% Emphysema":"16.7414","Exacerbation Frequency":"3"}
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"Subject ID":"-",
"Sample ID":"21711Y",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"65.2","Gender":"1","BMI":"25.16","FEV1/FVC":"0.76","FEV1 percent predicted":"113.5","BDR":"-","% Emphysema":"0.3225","Exacerbation Frequency":"-"}
},
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"Subject ID":"-",
"Sample ID":"21731E",
"Factors":{"Smoking Status":"1","Gold Stage":"2"},
"Additional sample data":{"Age":"67.7","Gender":"2","BMI":"23.39","FEV1/FVC":"0.68","FEV1 percent predicted":"79.6","BDR":"-","% Emphysema":"0.2267","Exacerbation Frequency":"-"}
},
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"Subject ID":"-",
"Sample ID":"21897M",
"Factors":{"Smoking Status":"-","Gold Stage":"1"},
"Additional sample data":{"Age":"69.8","Gender":"1","BMI":"25.5","FEV1/FVC":"0.54","FEV1 percent predicted":"83.9","BDR":"1","% Emphysema":"20.543","Exacerbation Frequency":"-"}
},
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"Subject ID":"-",
"Sample ID":"21920H",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"57.7","Gender":"1","BMI":"27.02","FEV1/FVC":"0.81","FEV1 percent predicted":"100.5","BDR":"-","% Emphysema":"4.9057","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"21929Z",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"57.2","Gender":"2","BMI":"23.31","FEV1/FVC":"0.74","FEV1 percent predicted":"97","BDR":"-","% Emphysema":"0.6702","Exacerbation Frequency":"-"}
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"Subject ID":"-",
"Sample ID":"21931M",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"59.8","Gender":"1","BMI":"27.96","FEV1/FVC":"0.7","FEV1 percent predicted":"98","BDR":"-","% Emphysema":"2.116","Exacerbation Frequency":"-"}
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"Subject ID":"-",
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"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"56.2","Gender":"2","BMI":"24.1","FEV1/FVC":"0.77","FEV1 percent predicted":"89.2","BDR":"-","% Emphysema":"0.4553","Exacerbation Frequency":"-"}
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"Subject ID":"-",
"Sample ID":"22155Z",
"Factors":{"Smoking Status":"1","Gold Stage":"-"},
"Additional sample data":{"Age":"61.8","Gender":"2","BMI":"19.69","FEV1/FVC":"0.75","FEV1 percent predicted":"84.1","BDR":"-","% Emphysema":"0.5356","Exacerbation Frequency":"-"}
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"Subject ID":"-",
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"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"54.4","Gender":"2","BMI":"21.03","FEV1/FVC":"0.79","FEV1 percent predicted":"95.1","BDR":"-","% Emphysema":"0.4149","Exacerbation Frequency":"-"}
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"Subject ID":"-",
"Sample ID":"22363G",
"Factors":{"Smoking Status":"1","Gold Stage":"-"},
"Additional sample data":{"Age":"48.7","Gender":"1","BMI":"33.22","FEV1/FVC":"0.77","FEV1 percent predicted":"80.6","BDR":"-","% Emphysema":"0.4676","Exacerbation Frequency":"-"}
},
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"Subject ID":"-",
"Sample ID":"22375N",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"64","Gender":"2","BMI":"32.8","FEV1/FVC":"0.83","FEV1 percent predicted":"116.6","BDR":"-","% Emphysema":"1.2075","Exacerbation Frequency":"1"}
},
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"Subject ID":"-",
"Sample ID":"22470H",
"Factors":{"Smoking Status":"1","Gold Stage":"-"},
"Additional sample data":{"Age":"45.2","Gender":"2","BMI":"24.29","FEV1/FVC":"0.79","FEV1 percent predicted":"91.6","BDR":"-","% Emphysema":"0.0516","Exacerbation Frequency":"-"}
},
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"Subject ID":"-",
"Sample ID":"22542G",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"62.5","Gender":"1","BMI":"25.81","FEV1/FVC":"0.76","FEV1 percent predicted":"103.4","BDR":"-","% Emphysema":"2.3523","Exacerbation Frequency":"-"}
},
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"Subject ID":"-",
"Sample ID":"22544K",
"Factors":{"Smoking Status":"-","Gold Stage":"1"},
"Additional sample data":{"Age":"71.5","Gender":"2","BMI":"24.14","FEV1/FVC":"0.66","FEV1 percent predicted":"83.7","BDR":"1","% Emphysema":"4.9202","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"22545M",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"52.9","Gender":"2","BMI":"29.48","FEV1/FVC":"0.77","FEV1 percent predicted":"86.6","BDR":"-","% Emphysema":"0.9056","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"22569A",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"69.8","Gender":"1","BMI":"26.8","FEV1/FVC":"0.85","FEV1 percent predicted":"107.8","BDR":"-","% Emphysema":"0.5447","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"22602Y",
"Factors":{"Smoking Status":"1","Gold Stage":"-"},
"Additional sample data":{"Age":"52.5","Gender":"2","BMI":"23.36","FEV1/FVC":"0.71","FEV1 percent predicted":"88.3","BDR":"-","% Emphysema":"0.469","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"22623G",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"73.4","Gender":"1","BMI":"31.32","FEV1/FVC":"0.6","FEV1 percent predicted":"65.6","BDR":"1","% Emphysema":"13.0636","Exacerbation Frequency":"2"}
},
{
"Subject ID":"-",
"Sample ID":"22660M",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"72.6","Gender":"2","BMI":"23.81","FEV1/FVC":"0.76","FEV1 percent predicted":"102.1","BDR":"-","% Emphysema":"3.4596","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"22691X",
"Factors":{"Smoking Status":"1","Gold Stage":"2"},
"Additional sample data":{"Age":"58.2","Gender":"2","BMI":"29.46","FEV1/FVC":"0.62","FEV1 percent predicted":"75.4","BDR":"1","% Emphysema":"1.2098","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"22692Z",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"48.6","Gender":"2","BMI":"36.83","FEV1/FVC":"0.82","FEV1 percent predicted":"104.7","BDR":"-","% Emphysema":"0.9297","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"22721G",
"Factors":{"Smoking Status":"-","Gold Stage":"4"},
"Additional sample data":{"Age":"57.3","Gender":"2","BMI":"21.68","FEV1/FVC":"0.24","FEV1 percent predicted":"18","BDR":"1","% Emphysema":"23.0203","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"22723K",
"Factors":{"Smoking Status":"-","Gold Stage":"1"},
"Additional sample data":{"Age":"57.6","Gender":"1","BMI":"27.32","FEV1/FVC":"0.59","FEV1 percent predicted":"84.5","BDR":"-","% Emphysema":"1.1811","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"22752R",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"75.4","Gender":"2","BMI":"22.14","FEV1/FVC":"0.45","FEV1 percent predicted":"62","BDR":"-","% Emphysema":"21.0042","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"22753T",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"68.9","Gender":"2","BMI":"32.07","FEV1/FVC":"0.77","FEV1 percent predicted":"81.5","BDR":"-","% Emphysema":"1.2664","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"22754V",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"69.1","Gender":"1","BMI":"27.79","FEV1/FVC":"0.68","FEV1 percent predicted":"79.4","BDR":"-","% Emphysema":"2.1492","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"22756Z",
"Factors":{"Smoking Status":"-","Gold Stage":"1"},
"Additional sample data":{"Age":"56.2","Gender":"2","BMI":"19.47","FEV1/FVC":"0.65","FEV1 percent predicted":"82","BDR":"-","% Emphysema":"NA","Exacerbation Frequency":"3"}
},
{
"Subject ID":"-",
"Sample ID":"22951X",
"Factors":{"Smoking Status":"1","Gold Stage":"-"},
"Additional sample data":{"Age":"51.4","Gender":"2","BMI":"35.02","FEV1/FVC":"0.81","FEV1 percent predicted":"89.4","BDR":"-","% Emphysema":"0.0886","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"22986Q",
"Factors":{"Smoking Status":"1","Gold Stage":"2"},
"Additional sample data":{"Age":"49.4","Gender":"2","BMI":"19.98","FEV1/FVC":"0.58","FEV1 percent predicted":"69.4","BDR":"1","% Emphysema":"5.0953","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"23089R",
"Factors":{"Smoking Status":"-","Gold Stage":"4"},
"Additional sample data":{"Age":"65.4","Gender":"2","BMI":"33.46","FEV1/FVC":"0.34","FEV1 percent predicted":"8.9","BDR":"-","% Emphysema":"NA","Exacerbation Frequency":"2"}
},
{
"Subject ID":"-",
"Sample ID":"23090C",
"Factors":{"Smoking Status":"-","Gold Stage":"1"},
"Additional sample data":{"Age":"67.3","Gender":"1","BMI":"25.31","FEV1/FVC":"0.67","FEV1 percent predicted":"82.9","BDR":"-","% Emphysema":"2.9371","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"23091E",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"66.4","Gender":"2","BMI":"30.03","FEV1/FVC":"0.71","FEV1 percent predicted":"91.5","BDR":"-","% Emphysema":"7.8524","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"23124T",
"Factors":{"Smoking Status":"1","Gold Stage":"2"},
"Additional sample data":{"Age":"62.4","Gender":"2","BMI":"24.53","FEV1/FVC":"0.43","FEV1 percent predicted":"58","BDR":"1","% Emphysema":"14.8882","Exacerbation Frequency":"2"}
},
{
"Subject ID":"-",
"Sample ID":"23294S",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"77.1","Gender":"1","BMI":"23.86","FEV1/FVC":"0.77","FEV1 percent predicted":"112.8","BDR":"-","% Emphysema":"1.5044","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"23575A",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"61.4","Gender":"1","BMI":"24.33","FEV1/FVC":"0.77","FEV1 percent predicted":"134.9","BDR":"-","% Emphysema":"2.6127","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"23611E",
"Factors":{"Smoking Status":"1","Gold Stage":"-"},
"Additional sample data":{"Age":"60.8","Gender":"1","BMI":"25.31","FEV1/FVC":"0.7","FEV1 percent predicted":"84.7","BDR":"-","% Emphysema":"0.4431","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"23744X",
"Factors":{"Smoking Status":"1","Gold Stage":"-"},
"Additional sample data":{"Age":"47","Gender":"1","BMI":"25.28","FEV1/FVC":"0.8","FEV1 percent predicted":"127.3","BDR":"-","% Emphysema":"1.1681","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"23851Y",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"73.5","Gender":"2","BMI":"26.5","FEV1/FVC":"0.43","FEV1 percent predicted":"41.9","BDR":"-","% Emphysema":"20.8766","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"24063E",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"69.9","Gender":"2","BMI":"30.67","FEV1/FVC":"0.43","FEV1 percent predicted":"66.3","BDR":"1","% Emphysema":"NA","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24158P",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"60.7","Gender":"2","BMI":"19.18","FEV1/FVC":"0.38","FEV1 percent predicted":"43.4","BDR":"-","% Emphysema":"38.2897","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24211T",
"Factors":{"Smoking Status":"1","Gold Stage":"2"},
"Additional sample data":{"Age":"56.4","Gender":"1","BMI":"32.48","FEV1/FVC":"0.6","FEV1 percent predicted":"59.7","BDR":"-","% Emphysema":"0.5221","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24213X",
"Factors":{"Smoking Status":"1","Gold Stage":"3"},
"Additional sample data":{"Age":"56","Gender":"1","BMI":"19.49","FEV1/FVC":"0.43","FEV1 percent predicted":"43.3","BDR":"-","% Emphysema":"47.331","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24309K",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"63.6","Gender":"1","BMI":"21.14","FEV1/FVC":"0.42","FEV1 percent predicted":"31.6","BDR":"1","% Emphysema":"31.8105","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"24344M",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"68.4","Gender":"2","BMI":"21.87","FEV1/FVC":"0.79","FEV1 percent predicted":"115.1","BDR":"-","% Emphysema":"1.8584","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24382U",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"79.5","Gender":"2","BMI":"21.93","FEV1/FVC":"0.8","FEV1 percent predicted":"123.1","BDR":"-","% Emphysema":"0.4117","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24394B",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"53.8","Gender":"2","BMI":"26.06","FEV1/FVC":"0.76","FEV1 percent predicted":"89.6","BDR":"-","% Emphysema":"0.4016","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24429U",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"63.9","Gender":"2","BMI":"26.73","FEV1/FVC":"0.62","FEV1 percent predicted":"64.4","BDR":"-","% Emphysema":"10.7203","Exacerbation Frequency":"2"}
},
{
"Subject ID":"-",
"Sample ID":"24438V",
"Factors":{"Smoking Status":"-","Gold Stage":"1"},
"Additional sample data":{"Age":"74.7","Gender":"1","BMI":"30.01","FEV1/FVC":"0.65","FEV1 percent predicted":"115.2","BDR":"-","% Emphysema":"19.4956","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"24449A",
"Factors":{"Smoking Status":"-","Gold Stage":"1"},
"Additional sample data":{"Age":"61.9","Gender":"1","BMI":"25.32","FEV1/FVC":"0.69","FEV1 percent predicted":"80.1","BDR":"-","% Emphysema":"10.0245","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24450L",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"69.8","Gender":"1","BMI":"31.58","FEV1/FVC":"0.46","FEV1 percent predicted":"42.1","BDR":"-","% Emphysema":"16.4386","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24456X",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"73.6","Gender":"1","BMI":"26.87","FEV1/FVC":"0.59","FEV1 percent predicted":"63.5","BDR":"-","% Emphysema":"14.0428","Exacerbation Frequency":"3"}
},
{
"Subject ID":"-",
"Sample ID":"24513J",
"Factors":{"Smoking Status":"1","Gold Stage":"2"},
"Additional sample data":{"Age":"58.4","Gender":"2","BMI":"32.09","FEV1/FVC":"0.67","FEV1 percent predicted":"63.4","BDR":"1","% Emphysema":"4.8711","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24514L",
"Factors":{"Smoking Status":"1","Gold Stage":"-"},
"Additional sample data":{"Age":"66.1","Gender":"1","BMI":"40.76","FEV1/FVC":"0.81","FEV1 percent predicted":"81.4","BDR":"1","% Emphysema":"0.7263","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24580Y",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"55.9","Gender":"1","BMI":"33.28","FEV1/FVC":"0.82","FEV1 percent predicted":"97.6","BDR":"-","% Emphysema":"1.425","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24593H",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"61.4","Gender":"1","BMI":"25.03","FEV1/FVC":"0.37","FEV1 percent predicted":"32.8","BDR":"1","% Emphysema":"28.2172","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24639F",
"Factors":{"Smoking Status":"-","Gold Stage":"4"},
"Additional sample data":{"Age":"67.8","Gender":"1","BMI":"22.39","FEV1/FVC":"0.24","FEV1 percent predicted":"14.3","BDR":"1","% Emphysema":"34.1094","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24653Z",
"Factors":{"Smoking Status":"1","Gold Stage":"-"},
"Additional sample data":{"Age":"61.3","Gender":"1","BMI":"32.52","FEV1/FVC":"0.71","FEV1 percent predicted":"99.8","BDR":"-","% Emphysema":"0.7106","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24670Z",
"Factors":{"Smoking Status":"1","Gold Stage":"3"},
"Additional sample data":{"Age":"59.9","Gender":"1","BMI":"32.12","FEV1/FVC":"0.46","FEV1 percent predicted":"44.8","BDR":"1","% Emphysema":"NA","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"24673F",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"76","Gender":"2","BMI":"30.96","FEV1/FVC":"0.56","FEV1 percent predicted":"60.9","BDR":"-","% Emphysema":"1.8405","Exacerbation Frequency":"2"}
},
{
"Subject ID":"-",
"Sample ID":"24678P",
"Factors":{"Smoking Status":"-","Gold Stage":"4"},
"Additional sample data":{"Age":"55.4","Gender":"2","BMI":"25.01","FEV1/FVC":"0.36","FEV1 percent predicted":"27.4","BDR":"-","% Emphysema":"NA","Exacerbation Frequency":"3"}
},
{
"Subject ID":"-",
"Sample ID":"24706U",
"Factors":{"Smoking Status":"1","Gold Stage":"3"},
"Additional sample data":{"Age":"67.4","Gender":"2","BMI":"43.32","FEV1/FVC":"0.61","FEV1 percent predicted":"40.4","BDR":"-","% Emphysema":"0.9713","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"24716X",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"57.2","Gender":"1","BMI":"33.46","FEV1/FVC":"0.83","FEV1 percent predicted":"104","BDR":"-","% Emphysema":"2.2816","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24718B",
"Factors":{"Smoking Status":"1","Gold Stage":"-"},
"Additional sample data":{"Age":"45.7","Gender":"2","BMI":"29.02","FEV1/FVC":"0.81","FEV1 percent predicted":"80.8","BDR":"1","% Emphysema":"0.8095","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24739J",
"Factors":{"Smoking Status":"-","Gold Stage":"1"},
"Additional sample data":{"Age":"52.8","Gender":"2","BMI":"36.8","FEV1/FVC":"0.68","FEV1 percent predicted":"92.4","BDR":"1","% Emphysema":"3.4395","Exacerbation Frequency":"3"}
},
{
"Subject ID":"-",
"Sample ID":"24745E",
"Factors":{"Smoking Status":"-","Gold Stage":"4"},
"Additional sample data":{"Age":"71.8","Gender":"2","BMI":"19.9","FEV1/FVC":"0.28","FEV1 percent predicted":"21.6","BDR":"1","% Emphysema":"27.0988","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24757L",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"69","Gender":"1","BMI":"44.66","FEV1/FVC":"0.51","FEV1 percent predicted":"36.9","BDR":"-","% Emphysema":"12.4754","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"24762E",
"Factors":{"Smoking Status":"1","Gold Stage":"2"},
"Additional sample data":{"Age":"53.7","Gender":"1","BMI":"26.68","FEV1/FVC":"0.58","FEV1 percent predicted":"73.2","BDR":"1","% Emphysema":"3.7391","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24825C",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"67.6","Gender":"2","BMI":"33.26","FEV1/FVC":"0.56","FEV1 percent predicted":"52","BDR":"-","% Emphysema":"8.1662","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"24826E",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"68.9","Gender":"1","BMI":"28.99","FEV1/FVC":"0.76","FEV1 percent predicted":"118.6","BDR":"-","% Emphysema":"1.401","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24902U",
"Factors":{"Smoking Status":"1","Gold Stage":"2"},
"Additional sample data":{"Age":"52.8","Gender":"2","BMI":"27.33","FEV1/FVC":"0.61","FEV1 percent predicted":"61.1","BDR":"-","% Emphysema":"0.1815","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"24918J",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"62.1","Gender":"1","BMI":"30.34","FEV1/FVC":"0.45","FEV1 percent predicted":"40.5","BDR":"-","% Emphysema":"24.4507","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24927K",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"62.9","Gender":"1","BMI":"28.93","FEV1/FVC":"0.46","FEV1 percent predicted":"44.6","BDR":"1","% Emphysema":"12.3802","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"24931B",
"Factors":{"Smoking Status":"-","Gold Stage":"1"},
"Additional sample data":{"Age":"79.5","Gender":"1","BMI":"25.89","FEV1/FVC":"0.56","FEV1 percent predicted":"84","BDR":"-","% Emphysema":"17.002","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"25020R",
"Factors":{"Smoking Status":"-","Gold Stage":"4"},
"Additional sample data":{"Age":"61.4","Gender":"1","BMI":"25.94","FEV1/FVC":"0.44","FEV1 percent predicted":"15.5","BDR":"-","% Emphysema":"28.7679","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"25023X",
"Factors":{"Smoking Status":"-","Gold Stage":"2"},
"Additional sample data":{"Age":"78.4","Gender":"1","BMI":"27.5","FEV1/FVC":"0.58","FEV1 percent predicted":"59.2","BDR":"1","% Emphysema":"4.9119","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"25036G",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"65.5","Gender":"1","BMI":"23.68","FEV1/FVC":"0.75","FEV1 percent predicted":"106.7","BDR":"-","% Emphysema":"0.4214","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"25214E",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"73.3","Gender":"1","BMI":"27.74","FEV1/FVC":"0.73","FEV1 percent predicted":"84.5","BDR":"-","% Emphysema":"0.2548","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"25229R",
"Factors":{"Smoking Status":"-","Gold Stage":"-"},
"Additional sample data":{"Age":"59.9","Gender":"1","BMI":"32.09","FEV1/FVC":"0.73","FEV1 percent predicted":"80.2","BDR":"1","% Emphysema":"4.4928","Exacerbation Frequency":"1"}
},
{
"Subject ID":"-",
"Sample ID":"25237Q",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"67.9","Gender":"1","BMI":"27.29","FEV1/FVC":"0.52","FEV1 percent predicted":"45.4","BDR":"-","% Emphysema":"1.5127","Exacerbation Frequency":"-"}
},
{
"Subject ID":"-",
"Sample ID":"25366B",
"Factors":{"Smoking Status":"-","Gold Stage":"3"},
"Additional sample data":{"Age":"59.6","Gender":"1","BMI":"27.19","FEV1/FVC":"0.42","FEV1 percent predicted":"35.6","BDR":"1","% Emphysema":"20.6796","Exacerbation Frequency":"-"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"All subjects were from the COPDGene cohort1, an NIH-sponsored multi-centered study of the genetic epidemiology of COPD. Subjects had fresh frozen plasma collected using a p100 tube (BD) at one of the COPDGene sites (National Jewish Health). Additional information on the COPDGene study and the collection of clinical data has been previously described1.” 1 Regan EA, Hokanson JE, Murphy JR, Make B, Lynch DA, Beaty TH et al. Genetic epidemiology of COPD (COPDGene) study design. COPD. 2010;7(1):32-43. doi:10.3109/15412550903499522.","SAMPLE_TYPE":"Plasma","BLOOD_SERUM_OR_PLASMA":"Plasma"},

"TREATMENT":{"TREATMENT_SUMMARY":"n/a"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"100µL of plasma was prepared using methanol to extract precipitate the proteins into a pellet. A liquid-liquid extraction with water and methyl-tert butyl ether (MTBE) was used to partition the supernatant into an aqueous layer and an organic layer (lipids). The aqueous layer was dried down in a SpeedVac at 45°C, then reconstituted in 100µL of 95:5 water:acetonitrile. The lipid fraction was dried down in a SpeedVac at 45°C, then reconstituted in 200µL of 100% methanol."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Aqueous Fraction (HILIC)","CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Agilent 6520","COLUMN_NAME":"Phenomenex Kinetex HILIC 100A (50 x 2.1 mm, 2.6um)","FLOW_GRADIENT":"0.2 minutes 100% B, 2-2.1 minutes 100-90% B, 2.1-8.6 minutes 90-50% B, 8.6-8.7 minutes 50-0% B, 8.7-14.7 minutes 0% B, 14.7-14.8 minutes 0-100% B, followed by column re-equilibration","FLOW_RATE":"0.6 mL/min","COLUMN_TEMPERATURE":"20°C","SOLVENT_A":"50% ACN with pH 5.8 ammonium acetate","SOLVENT_B":"90% ACN with pH 5.8 ammonium acetate","INJECTION_TEMPERATURE":"4°C","SAMPLE_INJECTION":"1µL","CAPILLARY_VOLTAGE":"4000V","RANDOMIZATION_ORDER":"Excel rand() function"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"Agilent","INSTRUMENT_TYPE":"QTOF","MS_TYPE":"ESI","ION_MODE":"POSITIVE","FRAGMENT_VOLTAGE":"120V","SCANNING_RANGE":"50-1700m/z","SKIMMER_VOLTAGE":"60V","MS_RESULTS_FILE":"ST000601_AN000921_Results.txt UNITS:Counts"}

}