{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000890","ANALYSIS_ID":"AN001452","VERSION":"1","CREATED_ON":"November 8, 2017, 9:35 am"},

"PROJECT":{"PROJECT_TITLE":"Endogenous Retinoid X Receptor Ligands in Mouse Hemotopoietic Cells","PROJECT_TYPE":"MS Identification and Quantification of Ligands","PROJECT_SUMMARY":"The retinoid X receptor α (RXRA) has been implicated in diverse hematological processes. However, it is unknown whether natural ligands of RXRA are present or regulated in hematopoietic cells. We quantified lipids in the serum of mice treated with a vitamin A deficient diet, a fatty acid deficient diet, and following phenylhydrazine treatment. In parallel, these serum samples were applied to RXRA reporter cells to identify conditions which contained increased concentrations of natural RXRA ligands. Mass spectrometry quantification of serum lipids was correlated with data from the RXRA reporter cells to identify serum lipids that increased in conditions associated with augmented RXRA ligand concentrations in the RXRA reporter assay.","INSTITUTE":"Washington University Scholl of Medicine","DEPARTMENT":"Diabetic Cardiovascular Disease Center, School of Medicine","LABORATORY":"Metabolomics Core","LAST_NAME":"Fujiwara","FIRST_NAME":"Hideji","ADDRESS":"660 South Euclide Avenue, St. Lois, MO 63110","EMAIL":"hfujiwar@wustl.edu","PHONE":"314-747-0494","FUNDING_SOURCE":"NIH R01 HL128447, NIH P30 DK020579","PUBLICATIONS":"Science Signaling 2018, being accepted for publication","CONTRIBUTORS":"Haixia Niu, Hideji Fujiwara, Orsola di Martino, Gayla Hadwiger, Thomas E. Frederick, María P. Menéndez-Gutiérrez, Mercedes Ricote, Gregory R. Bowman, John S. Welch"},

"STUDY":{"STUDY_TITLE":"Identification of RXR Ligands","STUDY_TYPE":"Idenfication of Ligands by HPLC-MS","STUDY_SUMMARY":"Free fatty acids in mouse plasma were identified and quantified by LC-MS. Through differential feeding and PHZ (phnylhydrazine) dosing, coupled with mass spectrometry, we identified the long chain fatty acid C24:5 as a natural RXRA ligand, which was dynamically increased in concentration in response to hematopoietic stress. Collectively, these data demonstrate that natural RXRA ligands are present and are dynamically regulated in vivo in mouse hematopoietic cells.","INSTITUTE":"Washington University School of Medicine","DEPARTMENT":"Diabetic Cardiovascular Disease Center","LABORATORY":"Metabolomics Core","LAST_NAME":"Fujiwara","FIRST_NAME":"Hideji","ADDRESS":"660 South Euclid Ave, St. Louis MO 63110","EMAIL":"hfujiwar@wustl.edu","PHONE":"314-747-0494"},

"SUBJECT":{"SUBJECT_TYPE":"Animals","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090","GENOTYPE_STRAIN":"C57/B6","AGE_OR_AGE_RANGE":"8-16 weeks"},
"SUBJECT_SAMPLE_FACTORS":[
{
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"Sample ID":"4629 PB1-PHZ",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"4630 PB1-PHZ",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"4632 PB1",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"4633 PB1",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"4629 BM1-PHZ",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"4630 BM1-PHZ",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"4632 BM1",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"4633 BM1",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"4629 PB2-PHZ",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"4630 PB2-PHZ",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"4632 PB2",
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},
{
"Subject ID":"mouse serum",
"Sample ID":"4633 PB2",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"4629 BM2-PHZ",
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},
{
"Subject ID":"mouse serum",
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},
{
"Subject ID":"mouse serum",
"Sample ID":"4632 BM2",
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},
{
"Subject ID":"mouse serum",
"Sample ID":"4633 BM2",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD1-11",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD1-21",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD1-31",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD1-41",
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},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ1-11",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
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{
"Subject ID":"mouse serum",
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"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ1-41",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD1-12",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD1-22",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD1-32",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD1-42",
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},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ1-12",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ1-22",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ1-32",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ1-42",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-1",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-2",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-3",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-4",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-PHZ-1",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-PHZ-2",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-PHZ-3",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-PHZ-4",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-PHZ-5",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-1",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-2",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-3",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-11",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-21",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-31",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-PHZ-21",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-PHZ-31",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-PHZ-41",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NFC-PHZ-11",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"4","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NFC-PHZ-21",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"4","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-12",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-22",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-32",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-PHZ-22",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-PHZ-32",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-PHZ-42",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NFC-PHZ-12",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"4","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NFC-PHZ-22",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"4","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-13",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-23",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-33",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"NF-PHZ-23",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
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},
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"Subject ID":"mouse serum",
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},
{
"Subject ID":"mouse serum",
"Sample ID":"NFC-PHZ-13",
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},
{
"Subject ID":"mouse serum",
"Sample ID":"NFC-PHZ-23",
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},
{
"Subject ID":"mouse serum",
"Sample ID":"VDAC21",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VDAC31",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VDAC41",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VDAC51",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD2-11",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD2-21",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD2-31",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD2-41",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD2-51",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ2-11",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ2-21",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ2-31",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ2-41",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ2-51",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"FC-11",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"FC-21",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"FC-31",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"FC-41",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"F-11",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"F-21",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"F-31",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"F-41",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"F-51",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VDAC22",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VDAC32",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VDAC42",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VDAC52",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD2-12",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD2-22",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD2-32",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD2-42",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD2-52",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ2-12",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ2-22",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ2-32",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ2-42",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD-PHZ2-52",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"1"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"FC-12",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"FC-22",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"FC-32",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"FC-42",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"F-12",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"F-22",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"F-32",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"F-42",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"F-52",
"Factors":{"Diet of subject mice":"Non-fat-diet","Feeding period (wk)":"4","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD3-11",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD3-21",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD3-31",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD3-41",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD3-51",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD3-12",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD3-22",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD3-32",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD3-42",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VAD3-52",
"Factors":{"Diet of subject mice":"vitamin A deficient diet","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-13",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-23",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-33",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-43",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
},
{
"Subject ID":"mouse serum",
"Sample ID":"VADC-53",
"Factors":{"Diet of subject mice":"control chow","Feeding period (wk)":"12","PHZ dose (mg)":"mock"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Mouse plasma was collected by obtaining peripheral blood via peri-orbital bleeding. Approximately 100 ul blood is placed in a microvette vial with pre-loaded KEDTA and then centrifuged at 14,000 rpm for 10 minutes at 4 degrees. Plasma is removed and stored at -80 C until analysis."},

"TREATMENT":{"TREATMENT_SUMMARY":"Phenylhydrazine was administered at 1mg once on day 1 and plasma was collected on day 4. Vitamin A deficient diet: Teklad, TD.86143. Control diet: Teklad, TD.91280. Fatty acid deficient diet: Teklad, TD.03314. Control diet: Teklad, TD.130321."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"For free fatty acids analysis, 100 μL of plasma extraction sample or 400 μL pull-down samples was used for DMAPA (dimethylaminopropylamine) derivatization for improving MS sensitivity of free fatty acids. Prior to the derivatization, 50 ng of AA-d8 (deuterated arachidonic acid –d8) as the internal standard was added to each sample. The solvents in the sample were dried under a stream of nitrogen. To derivatize the sample, 50 μL of 50 mM EDC (N-ethyl-N-(3-dimethylaminopropyl)-carbodiimide hydrochloride) and 50 mM DMAPA and 50 mM DMAP (4-dimethylaminopyridine) were added to the dried fatty acid samples and heated at 50 ◦C for 30 minutes. The samples were dried under nitrogen and then dissolved in 1 mL of ethanol : water for MS."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"For DMAPA derivatized Fatty acid analysis. Shimadzu 20AD two pump system was used. Solvent A: 0.1% formic acid in water. Solvent B: 0.1% in Acetonitrile. The initial LC condition was 30% B. The solvent gradient was programmed from 30% B to 99% B in 4 min and was hold for 1 min at the flow rate of 1 mL/min. Then, it was immediately brought back to 30 % B and was hold for 2 min. An Agilent Eclipse XDB-C18 column (3.0 x100 mm x 3.5 µm) was used for this analysis.","CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Shimadzu 20AD","COLUMN_NAME":"Agilent Eclipse XDB-C18 (100 x 3.0mm,3.5um)","FLOW_GRADIENT":"30% B to 99% B in 4 min","FLOW_RATE":"1 mL/min","COLUMN_TEMPERATURE":"60 C","SOLVENT_A":"0.1% formic acid in water","SOLVENT_B":"0.1% formic acid in ACN","ANALYTICAL_TIME":"7 min"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"MS_COMMENTS":"-","INSTRUMENT_NAME":"ABI Sciex API 4000 QTrap","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","ION_MODE":"POSITIVE"},

"MS_METABOLITE_DATA":{
"Units":"peak area ratio",

"Data":[{"Metabolite":"Fatty Acid C18:3 α-Linoleic acid","4629 PB1-PHZ":"1.37","4630 PB1-PHZ":"1.13","4632 PB1":"0.865","4633 PB1":"0.875","4629 BM1-PHZ":"0.332","4630 BM1-PHZ":"0.498","4632 BM1":"0.659","4633 BM1":"0.291","4629 PB2-PHZ":"1.4","4630 PB2-PHZ":"1.15","4632 PB2":"0.873","4633 PB2":"0.853","4629 BM2-PHZ":"0.298","4630 BM2-PHZ":"0.519","4632 BM2":"0.72","4633 BM2":"0.276","VAD1-11":"0.488","VAD1-21":"0.704","VAD1-31":"0.6","VAD1-41":"0.446","VAD-PHZ1-11":"0.857","VAD-PHZ1-21":"0.649","VAD-PHZ1-31":"0.627","VAD-PHZ1-41":"0.793","VAD1-12":"0.459","VAD1-22":"0.685","VAD1-32":"0.583","VAD1-42":"0.474","VAD-PHZ1-12":"0.88","VAD-PHZ1-22":"0.663","VAD-PHZ1-32":"0.58","VAD-PHZ1-42":"0.769","VADC-1":"0.435","VADC-2":"0.408","VADC-3":"0.339","VADC-4":"0.795","VADC-PHZ-1":"0.906","VADC-PHZ-2":"0.941","VADC-PHZ-3":"0.734","VADC-PHZ-4":"0.98","VADC-PHZ-5":"0.606","NF-1":"1.61","NF-2":"2.07","NF-3":"1.32","NF-11":"1.84","NF-21":"2.14","NF-31":"1.23","NF-PHZ-21":"1.6","NF-PHZ-31":"1.1","NF-PHZ-41":"2.19","NFC-PHZ-11":"3.18","NFC-PHZ-21":"4.09","NF-12":"1.86","NF-22":"2.32","NF-32":"1.26","NF-PHZ-22":"1.78","NF-PHZ-32":"1","NF-PHZ-42":"2.24","NFC-PHZ-12":"3.13","NFC-PHZ-22":"4.03","NF-13":"1.51","NF-23":"2.24","NF-33":"1.24","NF-PHZ-23":"1.85","NF-PHZ-33":"1.11","NF-PHZ-43":"2.25","NFC-PHZ-13":"3.11","NFC-PHZ-23":"4.12"},{"Metabolite":"Fatty Acid C20:2 Eicosadienoic acid","4629 PB1-PHZ":"0.371","4630 PB1-PHZ":"0.284","4632 PB1":"0.182","4633 PB1":"0.433","4629 BM1-PHZ":"0.27","4630 BM1-PHZ":"0.528","4632 BM1":"0.384","4633 BM1":"0.238","4629 PB2-PHZ":"0.361","4630 PB2-PHZ":"0.289","4632 PB2":"0.17","4633 PB2":"0.413","4629 BM2-PHZ":"0.241","4630 BM2-PHZ":"0.551","4632 BM2":"0.411","4633 BM2":"0.251","VAD1-11":"0.212","VAD1-21":"0.18","VAD1-31":"0.248","VAD1-41":"0.191","VAD-PHZ1-11":"0.401","VAD-PHZ1-21":"0.245","VAD-PHZ1-31":"0.241","VAD-PHZ1-41":"0.321","VAD1-12":"0.221","VAD1-22":"0.183","VAD1-32":"0.267","VAD1-42":"0.182","VAD-PHZ1-12":"0.407","VAD-PHZ1-22":"0.234","VAD-PHZ1-32":"0.222","VAD-PHZ1-42":"0.293","VADC-1":"0.317","VADC-2":"0.248","VADC-3":"0.33","VADC-4":"0.303","VADC-PHZ-1":"0.539","VADC-PHZ-2":"0.782","VADC-PHZ-3":"0.538","VADC-PHZ-4":"0.693","VADC-PHZ-5":"0.457","NF-1":"0.96","NF-2":"0.985","NF-3":"0.766","NF-11":"1.05","NF-21":"0.967","NF-31":"0.734","NF-PHZ-21":"0.977","NF-PHZ-31":"0.882","NF-PHZ-41":"0.887","NFC-PHZ-11":"1.8","NFC-PHZ-21":"1.85","NF-12":"1.08","NF-22":"1.09","NF-32":"0.726","NF-PHZ-22":"1.05","NF-PHZ-32":"0.88","NF-PHZ-42":"0.944","NFC-PHZ-12":"1.71","NFC-PHZ-22":"1.66","NF-13":"1.12","NF-23":"1.05","NF-33":"0.703","NF-PHZ-23":"1.06","NF-PHZ-33":"0.841","NF-PHZ-43":"0.977","NFC-PHZ-13":"1.89","NFC-PHZ-23":"1.9"},{"Metabolite":"Fatty Acid C20:3 Mead acid","4629 PB1-PHZ":"0.357","4630 PB1-PHZ":"0.274","4632 PB1":"0.252","4633 PB1":"0.238","4629 BM1-PHZ":"0.28","4630 BM1-PHZ":"0.396","4632 BM1":"0.316","4633 BM1":"0.181","4629 PB2-PHZ":"0.365","4630 PB2-PHZ":"0.26","4632 PB2":"0.251","4633 PB2":"0.23","4629 BM2-PHZ":"0.254","4630 BM2-PHZ":"0.415","4632 BM2":"0.337","4633 BM2":"0.209","VAD1-11":"0.332","VAD1-21":"0.229","VAD1-31":"0.349","VAD1-41":"0.269","VAD-PHZ1-11":"0.597","VAD-PHZ1-21":"0.23","VAD-PHZ1-31":"0.263","VAD-PHZ1-41":"0.373","VAD1-12":"0.32","VAD1-22":"0.238","VAD1-32":"0.329","VAD1-42":"0.258","VAD-PHZ1-12":"0.6","VAD-PHZ1-22":"0.24","VAD-PHZ1-32":"0.25","VAD-PHZ1-42":"0.342","VADC-1":"0.588","VADC-2":"0.44","VADC-3":"0.447","VADC-4":"0.435","VADC-PHZ-1":"0.838","VADC-PHZ-2":"0.859","VADC-PHZ-3":"0.736","VADC-PHZ-4":"0.761","VADC-PHZ-5":"0.731","NF-1":"0.922","NF-2":"0.927","NF-3":"0.669","NF-11":"1.01","NF-21":"0.868","NF-31":"0.755","NF-PHZ-21":"1.01","NF-PHZ-31":"0.862","NF-PHZ-41":"1.15","NFC-PHZ-11":"1.03","NFC-PHZ-21":"1.25","NF-12":"1.08","NF-22":"0.879","NF-32":"0.653","NF-PHZ-22":"1.07","NF-PHZ-32":"0.802","NF-PHZ-42":"1.17","NFC-PHZ-12":"1.09","NFC-PHZ-22":"1.05","NF-13":"1.13","NF-23":"0.963","NF-33":"0.632","NF-PHZ-23":"1.15","NF-PHZ-33":"0.847","NF-PHZ-43":"1.25","NFC-PHZ-13":"1.25","NFC-PHZ-23":"1.42"},{"Metabolite":"Fatty Acid C20:5","4629 PB1-PHZ":"0.298","4630 PB1-PHZ":"0.212","4632 PB1":"0.208","4633 PB1":"0.182","4629 BM1-PHZ":"0.11","4630 BM1-PHZ":"0.213","4632 BM1":"0.178","4633 BM1":"0.104","4629 PB2-PHZ":"0.298","4630 PB2-PHZ":"0.219","4632 PB2":"0.207","4633 PB2":"0.197","4629 BM2-PHZ":"0.0986","4630 BM2-PHZ":"0.202","4632 BM2":"0.191","4633 BM2":"0.106","VAD1-11":"0","VAD1-21":"0.0161","VAD1-31":"0.00724","VAD1-41":"0.0135","VAD-PHZ1-11":"0.00309","VAD-PHZ1-21":"0.015","VAD-PHZ1-31":"0.0152","VAD-PHZ1-41":"0.0205","VAD1-12":"0.0108","VAD1-22":"0.00908","VAD1-32":"0.0141","VAD1-42":"0.0131","VAD-PHZ1-12":"0","VAD-PHZ1-22":"0.0174","VAD-PHZ1-32":"0.0135","VAD-PHZ1-42":"0.00752","VADC-1":"0.0203","VADC-2":"0.0147","VADC-3":"0","VADC-4":"0.0268","VADC-PHZ-1":"0.0316","VADC-PHZ-2":"0.0505","VADC-PHZ-3":"0.0389","VADC-PHZ-4":"0.0484","VADC-PHZ-5":"0.0844","NF-1":"0.153","NF-2":"0.212","NF-3":"0.302","NF-11":"0.475","NF-21":"0.214","NF-31":"0.605","NF-PHZ-21":"0.635","NF-PHZ-31":"0.166","NF-PHZ-41":"0.631","NFC-PHZ-11":"0.217","NFC-PHZ-21":"0.647","NF-12":"0.476","NF-22":"0.26","NF-32":"0.563","NF-PHZ-22":"0.408","NF-PHZ-32":"0.166","NF-PHZ-42":"0.315","NFC-PHZ-12":"0.204","NFC-PHZ-22":"0.645","NF-13":"0.136","NF-23":"0.224","NF-33":"0.534","NF-PHZ-23":"0.396","NF-PHZ-33":"0.16","NF-PHZ-43":"0.314","NFC-PHZ-13":"0.173","NFC-PHZ-23":"0.343"},{"Metabolite":"Fatty Acid C22:0 Behenic acid","4629 PB1-PHZ":"0.138","4630 PB1-PHZ":"0.124","4632 PB1":"0.121","4633 PB1":"0.37","4629 BM1-PHZ":"0.194","4630 BM1-PHZ":"0.259","4632 BM1":"0.239","4633 BM1":"0.185","4629 PB2-PHZ":"0.136","4630 PB2-PHZ":"0.121","4632 PB2":"0.12","4633 PB2":"0.359","4629 BM2-PHZ":"0.183","4630 BM2-PHZ":"0.283","4632 BM2":"0.255","4633 BM2":"0.195","VAD1-11":"0.0977","VAD1-21":"0.104","VAD1-31":"0.11","VAD1-41":"0.108","VAD-PHZ1-11":"0.101","VAD-PHZ1-21":"0.0965","VAD-PHZ1-31":"0.0927","VAD-PHZ1-41":"0.0972","VAD1-12":"0.103","VAD1-22":"0.105","VAD1-32":"0.108","VAD1-42":"0.105","VAD-PHZ1-12":"0.102","VAD-PHZ1-22":"0.0932","VAD-PHZ1-32":"0.0945","VAD-PHZ1-42":"0.101","VADC-1":"0.109","VADC-2":"0.103","VADC-3":"0.0853","VADC-4":"0.116","VADC-PHZ-1":"0.138","VADC-PHZ-2":"0.16","VADC-PHZ-3":"0.11","VADC-PHZ-4":"0.157","VADC-PHZ-5":"0.0853","NF-1":"0.475","NF-2":"0.477","NF-3":"0.369","NF-11":"0.434","NF-21":"0.378","NF-31":"0.338","NF-PHZ-21":"0.349","NF-PHZ-31":"0.276","NF-PHZ-41":"0.372","NFC-PHZ-11":"0.648","NFC-PHZ-21":"0.69","NF-12":"0.388","NF-22":"0.411","NF-32":"0.332","NF-PHZ-22":"0.377","NF-PHZ-32":"0.287","NF-PHZ-42":"0.376","NFC-PHZ-12":"0.638","NFC-PHZ-22":"0.731","NF-13":"0.328","NF-23":"0.425","NF-33":"0.33","NF-PHZ-23":"0.392","NF-PHZ-33":"0.323","NF-PHZ-43":"0.365","NFC-PHZ-13":"0.656","NFC-PHZ-23":"0.81"},{"Metabolite":"Fatty Acid C22:1 Erucic acid","4629 PB1-PHZ":"0.0438","4630 PB1-PHZ":"0.0314","4632 PB1":"0.0246","4633 PB1":"0.111","4629 BM1-PHZ":"0.0347","4630 BM1-PHZ":"0.052","4632 BM1":"0.0442","4633 BM1":"0.0419","4629 PB2-PHZ":"0.0437","4630 PB2-PHZ":"0.0281","4632 PB2":"0.025","4633 PB2":"0.113","4629 BM2-PHZ":"0.0325","4630 BM2-PHZ":"0.0527","4632 BM2":"0.051","4633 BM2":"0.0471","VAD1-11":"0.0451","VAD1-21":"0.0487","VAD1-31":"0.0572","VAD1-41":"0.0539","VAD-PHZ1-11":"0.049","VAD-PHZ1-21":"0.039","VAD-PHZ1-31":"0.0706","VAD-PHZ1-41":"0.044","VAD1-12":"0.0444","VAD1-22":"0.0433","VAD1-32":"0.0526","VAD1-42":"0.051","VAD-PHZ1-12":"0.0471","VAD-PHZ1-22":"0.0363","VAD-PHZ1-32":"0.0647","VAD-PHZ1-42":"0.0414","VADC-1":"0.037","VADC-2":"0.0442","VADC-3":"0.034","VADC-4":"0.0459","VADC-PHZ-1":"0.0634","VADC-PHZ-2":"0.079","VADC-PHZ-3":"0.0421","VADC-PHZ-4":"0.0474","VADC-PHZ-5":"0.0299","NF-1":"0.0831","NF-2":"0.122","NF-3":"0.0833","NF-11":"0.0819","NF-21":"0.117","NF-31":"0.0803","NF-PHZ-21":"0.148","NF-PHZ-31":"0.12","NF-PHZ-41":"0.124","NFC-PHZ-11":"0.18","NFC-PHZ-21":"0.21","NF-12":"0.0739","NF-22":"0.113","NF-32":"0.0745","NF-PHZ-22":"0.164","NF-PHZ-32":"0.11","NF-PHZ-42":"0.127","NFC-PHZ-12":"0.188","NFC-PHZ-22":"0.2","NF-13":"0.0797","NF-23":"0.116","NF-33":"0.0783","NF-PHZ-23":"0.183","NF-PHZ-33":"0.119","NF-PHZ-43":"0.143","NFC-PHZ-13":"0.188","NFC-PHZ-23":"0.209"},{"Metabolite":"Fatty Acid C22:2 Docosadienoic acid","4629 PB1-PHZ":"0.0204","4630 PB1-PHZ":"0.0326","4632 PB1":"0.0141","4633 PB1":"0.0717","4629 BM1-PHZ":"0.0436","4630 BM1-PHZ":"0.105","4632 BM1":"0.0557","4633 BM1":"0.0395","4629 PB2-PHZ":"0.0244","4630 PB2-PHZ":"0.0339","4632 PB2":"0.0154","4633 PB2":"0.0817","4629 BM2-PHZ":"0.0423","4630 BM2-PHZ":"0.111","4632 BM2":"0.0619","4633 BM2":"0.0482","VAD1-11":"1.36","VAD1-21":"1.25","VAD1-31":"1.32","VAD1-41":"1.26","VAD-PHZ1-11":"1.34","VAD-PHZ1-21":"1.34","VAD-PHZ1-31":"1.36","VAD-PHZ1-41":"1.5","VAD1-12":"1.36","VAD1-22":"1.25","VAD1-32":"1.3","VAD1-42":"1.25","VAD-PHZ1-12":"1.43","VAD-PHZ1-22":"1.35","VAD-PHZ1-32":"1.28","VAD-PHZ1-42":"1.45","VADC-1":"1.66","VADC-2":"1.55","VADC-3":"1.27","VADC-4":"1.4","VADC-PHZ-1":"1.39","VADC-PHZ-2":"1.33","VADC-PHZ-3":"1.31","VADC-PHZ-4":"1.22","VADC-PHZ-5":"1.34","NF-1":"2.53","NF-2":"2.76","NF-3":"2.67","NF-11":"2.82","NF-21":"3.27","NF-31":"3.07","NF-PHZ-21":"3.01","NF-PHZ-31":"2.82","NF-PHZ-41":"2.87","NFC-PHZ-11":"3.43","NFC-PHZ-21":"3.40","NF-12":"3.17","NF-22":"3.52","NF-32":"3.11","NF-PHZ-22":"3.22","NF-PHZ-32":"3.19","NF-PHZ-42":"3.04","NFC-PHZ-12":"3.82","NFC-PHZ-22":"3.51","NF-13":"3.00","NF-23":"3.50","NF-33":"3.21","NF-PHZ-23":"3.64","NF-PHZ-33":"3.34","NF-PHZ-43":"3.41","NFC-PHZ-13":"3.99","NFC-PHZ-23":"4.08"},{"Metabolite":"Fatty Acid C22:3","4629 PB1-PHZ":"0.0156","4630 PB1-PHZ":"0.0169","4632 PB1":"0.00795","4633 PB1":"0.0655","4629 BM1-PHZ":"0.0336","4630 BM1-PHZ":"0.0446","4632 BM1":"0.0274","4633 BM1":"0.0184","4629 PB2-PHZ":"0.0131","4630 PB2-PHZ":"0.0167","4632 PB2":"0.00806","4633 PB2":"0.0654","4629 BM2-PHZ":"0.0289","4630 BM2-PHZ":"0.0449","4632 BM2":"0.0277","4633 BM2":"0.0176","VAD1-11":"0.0214","VAD1-21":"0.0161","VAD1-31":"0.0193","VAD1-41":"0.0182","VAD-PHZ1-11":"0.0458","VAD-PHZ1-21":"0.0198","VAD-PHZ1-31":"0.0283","VAD-PHZ1-41":"0.0262","VAD1-12":"0.0199","VAD1-22":"0.0201","VAD1-32":"0.0206","VAD1-42":"0.0176","VAD-PHZ1-12":"0.0612","VAD-PHZ1-22":"0.0211","VAD-PHZ1-32":"0.0271","VAD-PHZ1-42":"0.0263","VADC-1":"0.0277","VADC-2":"0.0208","VADC-3":"0.0342","VADC-4":"0.0254","VADC-PHZ-1":"0.0621","VADC-PHZ-2":"0.076","VADC-PHZ-3":"0.0566","VADC-PHZ-4":"0.0576","VADC-PHZ-5":"0.0545","NF-1":"0.193","NF-2":"0.203","NF-3":"0.116","NF-11":"0.193","NF-21":"0.196","NF-31":"0.115","NF-PHZ-21":"0.155","NF-PHZ-31":"0.158","NF-PHZ-41":"0.132","NFC-PHZ-11":"0.286","NFC-PHZ-21":"0.278","NF-12":"0.196","NF-22":"0.211","NF-32":"0.11","NF-PHZ-22":"0.161","NF-PHZ-32":"0.154","NF-PHZ-42":"0.134","NFC-PHZ-12":"0.278","NFC-PHZ-22":"0.268","NF-13":"0.199","NF-23":"0.208","NF-33":"0.11","NF-PHZ-23":"0.181","NF-PHZ-33":"0.171","NF-PHZ-43":"0.14","NFC-PHZ-13":"0.31","NFC-PHZ-23":"0.289"},{"Metabolite":"Fatty 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}

}