{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000939","ANALYSIS_ID":"AN001540","VERSION":"1","CREATED_ON":"March 6, 2018, 8:23 pm"},

"PROJECT":{"PROJECT_TITLE":"Defining and Predicting Steroid-Resistance in Children with Nephrotic Syndrome by Metabolic Profiling","PROJECT_TYPE":"Metabolomics","PROJECT_SUMMARY":"Nephrotic syndrome (NS) is a very common kidney disease in children. Glucocorticoids (GC) are the primary therapy, but are ineffective in ~20% of children and ~50% of adult cases. Patients with steroid resistant NS (SRNS) fail to enter remission after prolonged oral GC treatment, and are at high risk for GC-induced side effects and progression to end-stage kidney disease. This study aimed to discover markers of steroid resistance that could be potentially used to predict SRNS at presentation, and develop an improved mechanistic definition of pediatric SRNS. Plasma samples were collected from 30 steroid sensitive NS (SSNS) and 15 SRNS patients, and paired samples analyzed which were collected both at disease presentation, prior to any steroid therapy, and after ~7 weeks of daily GC treatment. Broad spectrum 1HNMR data were acquired, binned, and concentration fit. Multivariate analyses and hypothesis testing were used to determine the metabolites that best differentiated the four phenotypic groups. Treatment effects on metabolomics profiles were observed between paired Pre- and Post- treatment SSNS groups, and between Post SSNS and SRNS groups. Metabolites most perturbed by GC treatment included lipoproteins , adipate, pyruvate, alanine, creatine, glucose, tyrosine, valine, and glutamine. Logistic regression using a stepwise variable selection method was used on Pre- samples to model the odds at clinical presentation of SRNS. After controlling for age, the step-wise logistic regression model selected increased glutamine (OR= 1.01; 0.99-1.02 95% CI) as a marker of SRNS. A similar model with children age >3 only, indicated that children with reduced levels of malonate (OR=0.94; 0.89-1.00 95% CI) had an increased odds of SRNS . Thus, malonate concentration may be a potential plasma biomarker for identifying SRNS at initial clinical presentation.","INSTITUTE":"The Ohio State University and Nationwide Children’s Hospital","DEPARTMENT":"Department of Pediatrics and Center for Clinical and Translational Research","LAST_NAME":"Smoyer and Agrawal","FIRST_NAME":"William E. and Shipra","ADDRESS":"700 Children's Drive, Columbus, OH 43205","EMAIL":"William.Smoyer@nationwidechildrens.org and shipra.agrawal@nationwidechildrens.org","PHONE":"(614) 722-4360","FUNDING_SOURCE":"NIH Grants 1UMDK10086601, 1U24DK097193, and 7K01GM109320"},

"STUDY":{"STUDY_TITLE":"Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome using Plasma Metabolomics","STUDY_TYPE":"Discovery Metabolomics","STUDY_SUMMARY":"Paired citrate plasma samples were collected from 27 steroid-sensitive and 14 steroid-resistant nephrotic syndrome participants prior to beginning treatment and after an average of 7 weeks (range 3-19 wks) of treatment with a corticosteroid.","INSTITUTE":"RTI International","DEPARTMENT":"Discovery-Sciences-Technology","LABORATORY":"NIH Eastern Regional Comprehensive Metabolomics Resource Core at UNC Chapel Hill (ERCMRC)","LAST_NAME":"Sumner","FIRST_NAME":"Susan","ADDRESS":"3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA","EMAIL":"susan_sumner@unc.edu","PHONE":"704-250-5000","TOTAL_SUBJECTS":"86","STUDY_COMMENTS":"Factor Description 1. Treatment Response R = Steroid Resistant; S = Steroid Sensitive; Steroid resistance was defined as failure to enter complete remission after 6-8 weeks of daily oral steroids; Steroid sensitive was defined as clinical remission after 6-8 weeks of daily oral steroids. 2. Draw Number Draw 1 sample, ‘Pre’, was collected at the time of disease presentation before even a single dose of glucocorticoids, and Draw 2 sample, ‘Post’, was collected after 6-10 weeks of Glucocorticoid therapy. 3. Age Age in years at the time of Draw 1, or 'Pre', sample collection Other sample data Weeks difference Time in weeks between draw 1, 'pre', and draw 2, 'post', treatment sample collection Gender M = male; F = female Race self-reported (Native American or Alaskan Native/Asian/Black or African American/Native Hawaiian or Other Pacific Islander/White/More than one race) Ethnicity self-reported (Hispanic or Latino/Not Hispanic or Latino/Unknown)"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"S_1_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"2","Weeks Difference":"3.9","Race":"Not disclosed","Ethnicity":"Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_1_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"2","Weeks Difference":"3.9","Race":"Not disclosed","Ethnicity":"Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_2_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"8","Weeks Difference":"4.3","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_2_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"8","Weeks Difference":"4.3","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_3_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"14","Weeks Difference":"7.3","Race":"Black/African American","Ethnicity":"Not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_3_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"14","Weeks Difference":"7.3","Race":"Black/African American","Ethnicity":"Not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_4_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"3","Weeks Difference":"19","Race":"Asian","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_4_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"3","Weeks Difference":"19","Race":"Asian","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_5_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"2","Weeks Difference":"5","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_5_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"2","Weeks Difference":"5","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_6_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"-","Weeks Difference":"6.4","Race":"white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_6_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"-","Weeks Difference":"6.4","Race":"white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_7_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"8","Weeks Difference":"4.7","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_7_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"8","Weeks Difference":"4.7","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_8_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"3","Weeks Difference":"5.9","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_8_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"3","Weeks Difference":"5.9","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_9_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"14","Weeks Difference":"7.4","Race":"white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_9_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"14","Weeks Difference":"7.4","Race":"white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_10_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"10","Weeks Difference":"2.7","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_10_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"10","Weeks Difference":"2.7","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_11_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"6","Weeks Difference":"-","Race":"Asian","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_12_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"3","Weeks Difference":"7","Race":"Not disclosed","Ethnicity":"Not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_12_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"3","Weeks Difference":"7","Race":"Not disclosed","Ethnicity":"Not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_13_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"13","Weeks Difference":"7.9","Race":"(Biracial) black/African American/white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_13_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"13","Weeks Difference":"7.9","Race":"(Biracial) black/African American/white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_14_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"6","Weeks Difference":"6.1","Race":"White","Ethnicity":"Not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_14_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"6","Weeks Difference":"6.1","Race":"White","Ethnicity":"Not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_15_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"12","Weeks Difference":"4.9","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_15_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"12","Weeks Difference":"4.9","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_16_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"-"},
"Additional sample data":{"Draw Number":"2","Age":"-","Weeks Difference":"6.9","Race":"-","Ethnicity":"-"}
},
{
"Subject ID":"-",
"Sample ID":"S_16_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"-"},
"Additional sample data":{"Draw Number":"1","Age":"-","Weeks Difference":"6.9","Race":"-","Ethnicity":"-"}
},
{
"Subject ID":"-",
"Sample ID":"S_17_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"12","Weeks Difference":"6.1","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_17_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"12","Weeks Difference":"6.1","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_18_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"5","Weeks Difference":"5","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_18_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"5","Weeks Difference":"5","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_19_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"3","Weeks Difference":"8.3","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_19_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"3","Weeks Difference":"8.3","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_20_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"11","Weeks Difference":"5","Race":"White","Ethnicity":"Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_20_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"11","Weeks Difference":"5","Race":"White","Ethnicity":"Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_21_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"10","Weeks Difference":"10.4","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_21_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"10","Weeks Difference":"10.4","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_22_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"2.6","Weeks Difference":"6.4","Race":"(biracial) asian/white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_22_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"2.6","Weeks Difference":"6.4","Race":"(biracial) asian/white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_23_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"7.8","Weeks Difference":"7","Race":"Asian","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_23_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"7.8","Weeks Difference":"7","Race":"Asian","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_24_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"6.04","Weeks Difference":"8.6","Race":"Asian","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_24_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"6.04","Weeks Difference":"8.6","Race":"Asian","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_25_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"5.6","Weeks Difference":"7","Race":"Asian","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_25_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"5.6","Weeks Difference":"7","Race":"Asian","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_26_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"12","Weeks Difference":"6","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_26_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"12","Weeks Difference":"6","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_27_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"3","Weeks Difference":"6.7","Race":"White","Ethnicity":"Not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_27_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"3","Weeks Difference":"6.7","Race":"White","Ethnicity":"Not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_28_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"2","Weeks Difference":"5.9","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_28_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"2","Weeks Difference":"5.9","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_29_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"14","Weeks Difference":"7","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_29_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"14","Weeks Difference":"7","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_30_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"5","Weeks Difference":"6","Race":"(Biracial) black/African American/White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_30_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"5","Weeks Difference":"6","Race":"(Biracial) black/African American/White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_31_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"9","Weeks Difference":"7.9","Race":"black/african american","Ethnicity":"Not diclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_31_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"9","Weeks Difference":"7.9","Race":"black/african american","Ethnicity":"Not diclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_32_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"6","Weeks Difference":"5.9","Race":"white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_32_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"6","Weeks Difference":"5.9","Race":"white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_33_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"6","Weeks Difference":"6.4","Race":"white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_33_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"6","Weeks Difference":"6.4","Race":"white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_34_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"15","Weeks Difference":"6.3","Race":"black/african american","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_34_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"15","Weeks Difference":"6.3","Race":"black/african american","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_35_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"-","Weeks Difference":"5.6","Race":"white","Ethnicity":"Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_35_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"-","Weeks Difference":"5.6","Race":"white","Ethnicity":"Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_36_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"-","Weeks Difference":"-","Race":"white","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_37_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"7","Weeks Difference":"8.1","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_37_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"7","Weeks Difference":"8.1","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_38_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"8","Weeks Difference":"8.4","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_38_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"8","Weeks Difference":"8.4","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_39_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"2","Weeks Difference":"6.6","Race":"white","Ethnicity":"Not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_39_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"2","Weeks Difference":"6.6","Race":"white","Ethnicity":"Not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_40_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"6","Weeks Difference":"6","Race":"Black/African American","Ethnicity":"Not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_40_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"6","Weeks Difference":"6","Race":"Black/African American","Ethnicity":"Not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_41_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"-"},
"Additional sample data":{"Draw Number":"1","Age":"-","Weeks Difference":"-","Race":"-","Ethnicity":"-"}
},
{
"Subject ID":"-",
"Sample ID":"S_42_B",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"4","Weeks Difference":"6.9","Race":"native american or alaskan native","Ethnicity":"Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_42_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"4","Weeks Difference":"6.9","Race":"native american or alaskan native","Ethnicity":"Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_43_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"2","Age":"4","Weeks Difference":"10.3","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_43_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"4","Weeks Difference":"10.3","Race":"Black/African American","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"S_44_B",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"M"},
"Additional sample data":{"Draw Number":"2","Age":"10","Weeks Difference":"11.3","Race":"not disclosed","Ethnicity":"not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_44_A",
"Factors":{"Treatment Response":"Steroid Resistant","Gender":"M"},
"Additional sample data":{"Draw Number":"1","Age":"10","Weeks Difference":"11.3","Race":"not disclosed","Ethnicity":"not disclosed"}
},
{
"Subject ID":"-",
"Sample ID":"S_45_A",
"Factors":{"Treatment Response":"Steroid Sensitive","Gender":"F"},
"Additional sample data":{"Draw Number":"1","Age":"13","Weeks Difference":"6.7","Race":"White","Ethnicity":"Not Hispanic or Latino"}
},
{
"Subject ID":"-",
"Sample ID":"TP1",
"Factors":{"Treatment Response":"Pool","Gender":"-"},
"Additional sample data":{"Draw Number":"-","Age":"-","Weeks Difference":"-","Race":"-","Ethnicity":"-"}
},
{
"Subject ID":"-",
"Sample ID":"TP2",
"Factors":{"Treatment Response":"Pool","Gender":"-"},
"Additional sample data":{"Draw Number":"-","Age":"-","Weeks Difference":"-","Race":"-","Ethnicity":"-"}
},
{
"Subject ID":"-",
"Sample ID":"TP3",
"Factors":{"Treatment Response":"Pool","Gender":"-"},
"Additional sample data":{"Draw Number":"-","Age":"-","Weeks Difference":"-","Race":"-","Ethnicity":"-"}
},
{
"Subject ID":"-",
"Sample ID":"TP4",
"Factors":{"Treatment Response":"Pool","Gender":"-"},
"Additional sample data":{"Draw Number":"-","Age":"-","Weeks Difference":"-","Race":"-","Ethnicity":"-"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"None","COLLECTION_PROTOCOL_COMMENTS":"Citrate plasma","SAMPLE_TYPE":"Blood (plasma)"},

"TREATMENT":{"TREATMENT_SUMMARY":"None"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Study sample aliquots of 180 µL were mixed with 60 µL 0.9% saline solution containing 0.2% NaN3 and 4 mM formate in D2O. A total pool was also created by combining 11 µL aliquots from each study sample, mixed thoroughly, divided into four 180 µL aliquots, and processed identically to study samples. All of the samples were thoroughly mixed on multiple tube vortex mixer for 30 s at 5000 rpm, centrifuged at room temperature and 12,000 rcf for 5 min. The supernatants (200 µL) were stored in a fresh 1.5 mL centrifuge tubes overnight at 4 C, before transfer into pre-labeled 3mm NMR tubes (Bruker-Biospin, Switzerland) on the day of analysis.","EXTRACT_STORAGE":"4℃"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"-","INSTRUMENT_NAME":"-","COLUMN_NAME":"-"},

"ANALYSIS":{"DATA_FORMAT":"1r, fid","ANALYSIS_TYPE":"NMR"},

"NM":{"INSTRUMENT_NAME":"Bruker Avance III","INSTRUMENT_TYPE":"FT-NMR","NMR_EXPERIMENT_TYPE":"1D-1H","FIELD_FREQUENCY_LOCK":"Deuterium","STANDARD_CONCENTRATION":"1 mM","SPECTROMETER_FREQUENCY":"700 MHz","NMR_PROBE":"CRYO QNP","NMR_SOLVENT":"D2O","NMR_TUBE_SIZE":"3 mm","SHIMMING_METHOD":"topshim","PULSE_SEQUENCE":"cpmgpr1d","WATER_SUPPRESSION":"Yes","PULSE_WIDTH":"12.781 us","POWER_LEVEL":"19 W","RECEIVER_GAIN":"4","OFFSET_FREQUENCY":"3294.20 Hz","CHEMICAL_SHIFT_REF_CPD":"formate","TEMPERATURE":"25","NUMBER_OF_SCANS":"128","DUMMY_SCANS":"4","ACQUISITION_TIME":"3.892 s","RELAXATION_DELAY":"2 s","SPECTRAL_WIDTH":"12 ppm","NUM_DATA_POINTS_ACQUIRED":"65536","REAL_DATA_POINTS":"65536","LINE_BROADENING":"0.5 Hz","ZERO_FILLING":"yes","APODIZATION":"Lorentzian","BASELINE_CORRECTION_METHOD":"Polynomial","CHEMICAL_SHIFT_REF_STD":"Formate","BINNED_INCREMENT":"0.04","BINNED_DATA_EXCLUDED_RANGE":"water (4.55 – 5.15 ppm) and citrate (2.47-2.565 and 2.61-2.70)"},

"NMR_METABOLITE_DATA":{
"Units":"mM in NMR Sample",

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