{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST000947","ANALYSIS_ID":"AN001554","VERSION":"1","CREATED_ON":"April 10, 2018, 10:17 pm"},

"PROJECT":{"PROJECT_TITLE":"Mayo Pilot and Feasibility: Mechanisms for Insulin Resistance in Polycystic Ovary Syndrome","PROJECT_SUMMARY":"Polycystic Ovary Syndrome (PCOS), a condition of androgen excess, infrequent ovulation, and insulin resistance is the most common endocrine disorder among premenopausal women. Little is known about the exact mechanisms of insulin resistance in PCOS and how metformin can improve insulin sensitivity, increase the frequency of ovulation and lower androgens in PCOS. Preliminary data from metabolomic analyses of amino acids demonstrate increased concentrations of lysine and its metabolite, α-aminoadipic acid (AAA), in PCOS versus obese controls. Interestingly, greater AAA concentrations predicted the development of type 2 diabetes in the Framingham epidemiologic cohort, experimentally lowers glucose in animal models and increases insulin secretion in vitro. To date, the mechanism for increased circulating concentrations of lysine and AAA in insulin-resistant individuals is not known. Building upon these findings, we have initiated a project to simultaneously study lysine and AAA kinetics for the first time in insulin-resistant individuals using stable isotope tracer methodology. We will evaluate: 1) whether lysine and AAA kinetics are altered in PCOS versus healthy controls; 2) the effect of hyperinsulinemia on lysine and AAA kinetics in PCOS versus controls; 3) whether treatment to improve insulin sensitivity changes lysine and AAA kinetics in PCOS. The long-term goal is to target pathways for the treatment of PCOS and the prevention of type 2 diabetes in PCOS and other insulin-resistant individuals at greater risk for type 2 diabetes.","INSTITUTE":"Mayo Clinic","LAST_NAME":"Chang","FIRST_NAME":"Alice","ADDRESS":"200 First St. SW, Rochester, Minnesota, 55905, USA","EMAIL":"Chang.Alice1@mayo.edu","PHONE":"507-286-0505"},

"STUDY":{"STUDY_TITLE":"Mechanisms for Insulin Resistance in Polycystic Ovary Syndrome: aminoadipic acid, lysine concentrations, and enrichment (part I)","STUDY_SUMMARY":"To determine whether altered lysine and α-aminoadipic acid (AAA) kinetics explain previous observations of increased lysine and AAA concentrations in PCOS compared to controls, as measured by baseline lysine and AAA flux in PCOS versus healthy controls using [α-15N]-lysine and [13C]-AAA stable isotope tracers as well as by comparing the conversion of [α-15N]-lysine to [15N]-AAA. To evaluate how hyperinsulinemia affects lysine and AAA kinetics. Changes in lysine and AAA flux during a hyperinsulinemic-euglycemic clamp will be evaluated in healthy controls and compared to the baseline changes in lysine and AAA flux in PCOS.","INSTITUTE":"Mayo Clinic","LAST_NAME":"Chang","FIRST_NAME":"Al","ADDRESS":"200 First St. SW, Rochester, Minnesota, 55905, USA","EMAIL":"Chang.Alice1@mayo.edu","PHONE":"507-286-0505"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"7744",
"Sample ID":"ms6032-1",
"Factors":{"Time point":"baseline","Group":"control"},
"Additional sample data":{"Date of study":"12/20/2015"}
},
{
"Subject ID":"7744",
"Sample ID":"ms6032-2",
"Factors":{"Time point":"-60","Group":"control"},
"Additional sample data":{"Date of study":"12/20/2015"}
},
{
"Subject ID":"7744",
"Sample ID":"ms6032-3",
"Factors":{"Time point":"-45","Group":"control"},
"Additional sample data":{"Date of study":"12/20/2015"}
},
{
"Subject ID":"7744",
"Sample ID":"ms6032-4",
"Factors":{"Time point":"-30","Group":"control"},
"Additional sample data":{"Date of study":"12/20/2015"}
},
{
"Subject ID":"7744",
"Sample ID":"ms6032-5",
"Factors":{"Time point":"-15","Group":"control"},
"Additional sample data":{"Date of study":"12/20/2015"}
},
{
"Subject ID":"7744",
"Sample ID":"ms6032-6",
"Factors":{"Time point":"60","Group":"control"},
"Additional sample data":{"Date of study":"12/20/2015"}
},
{
"Subject ID":"7744",
"Sample ID":"ms6032-7",
"Factors":{"Time point":"120","Group":"control"},
"Additional sample data":{"Date of study":"12/20/2015"}
},
{
"Subject ID":"7744",
"Sample ID":"ms6032-8",
"Factors":{"Time point":"135","Group":"control"},
"Additional sample data":{"Date of study":"12/20/2015"}
},
{
"Subject ID":"7744",
"Sample ID":"ms6032-9",
"Factors":{"Time point":"150","Group":"control"},
"Additional sample data":{"Date of study":"12/20/2015"}
},
{
"Subject ID":"7744",
"Sample ID":"ms6032-10",
"Factors":{"Time point":"165","Group":"control"},
"Additional sample data":{"Date of study":"12/20/2015"}
},
{
"Subject ID":"7744",
"Sample ID":"ms6032-11",
"Factors":{"Time point":"180","Group":"control"},
"Additional sample data":{"Date of study":"12/20/2015"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6039-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/14/2015"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6039-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/15/2015"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6039-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/15/2015"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6039-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/15/2015"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6039-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/15/2015"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6039-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/15/2015"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6039-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/15/2015"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6039-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/15/2015"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6039-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/15/2015"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6039-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/15/2015"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6039-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/15/2015"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6087-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/19/2016"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6087-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/20/2016"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6087-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/20/2016"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6087-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/20/2016"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6087-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/20/2016"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6087-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/20/2016"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6087-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/20/2016"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6087-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/20/2016"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6087-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/20/2016"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6087-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/20/2016"}
},
{
"Subject ID":"3437",
"Sample ID":"ms6087-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/20/2016"}
},
{
"Subject ID":"1002",
"Sample ID":"ms6184-1",
"Factors":{"Time point":"baseline","Group":"control"},
"Additional sample data":{"Date of study":"3/22/2016"}
},
{
"Subject ID":"1002",
"Sample ID":"ms6184-2",
"Factors":{"Time point":"-60","Group":"control"},
"Additional sample data":{"Date of study":"3/23/2016"}
},
{
"Subject ID":"1002",
"Sample ID":"ms6184-3",
"Factors":{"Time point":"-45","Group":"control"},
"Additional sample data":{"Date of study":"3/23/2016"}
},
{
"Subject ID":"1002",
"Sample ID":"ms6184-4",
"Factors":{"Time point":"-30","Group":"control"},
"Additional sample data":{"Date of study":"3/23/2016"}
},
{
"Subject ID":"1002",
"Sample ID":"ms6184-5",
"Factors":{"Time point":"-15","Group":"control"},
"Additional sample data":{"Date of study":"3/23/2016"}
},
{
"Subject ID":"1002",
"Sample ID":"ms6184-6",
"Factors":{"Time point":"60","Group":"control"},
"Additional sample data":{"Date of study":"3/23/2016"}
},
{
"Subject ID":"1002",
"Sample ID":"ms6184-7",
"Factors":{"Time point":"120","Group":"control"},
"Additional sample data":{"Date of study":"3/23/2016"}
},
{
"Subject ID":"1002",
"Sample ID":"ms6184-8",
"Factors":{"Time point":"135","Group":"control"},
"Additional sample data":{"Date of study":"3/23/2016"}
},
{
"Subject ID":"1002",
"Sample ID":"ms6184-9",
"Factors":{"Time point":"150","Group":"control"},
"Additional sample data":{"Date of study":"3/23/2016"}
},
{
"Subject ID":"1002",
"Sample ID":"ms6184-10",
"Factors":{"Time point":"165","Group":"control"},
"Additional sample data":{"Date of study":"3/23/2016"}
},
{
"Subject ID":"1002",
"Sample ID":"ms6184-11",
"Factors":{"Time point":"180","Group":"control"},
"Additional sample data":{"Date of study":"3/23/2016"}
},
{
"Subject ID":"2850",
"Sample ID":"ms6185-1",
"Factors":{"Time point":"baseline","Group":"control"},
"Additional sample data":{"Date of study":"5/11/2016"}
},
{
"Subject ID":"2850",
"Sample ID":"ms6185-2",
"Factors":{"Time point":"-60","Group":"control"},
"Additional sample data":{"Date of study":"5/12/2016"}
},
{
"Subject ID":"2850",
"Sample ID":"ms6185-3",
"Factors":{"Time point":"-45","Group":"control"},
"Additional sample data":{"Date of study":"5/12/2016"}
},
{
"Subject ID":"2850",
"Sample ID":"ms6185-4",
"Factors":{"Time point":"-30","Group":"control"},
"Additional sample data":{"Date of study":"5/12/2016"}
},
{
"Subject ID":"2850",
"Sample ID":"ms6185-5",
"Factors":{"Time point":"-15","Group":"control"},
"Additional sample data":{"Date of study":"5/12/2016"}
},
{
"Subject ID":"2850",
"Sample ID":"ms6185-6",
"Factors":{"Time point":"60","Group":"control"},
"Additional sample data":{"Date of study":"5/12/2016"}
},
{
"Subject ID":"2850",
"Sample ID":"ms6185-7",
"Factors":{"Time point":"120","Group":"control"},
"Additional sample data":{"Date of study":"5/12/2016"}
},
{
"Subject ID":"2850",
"Sample ID":"ms6185-8",
"Factors":{"Time point":"135","Group":"control"},
"Additional sample data":{"Date of study":"5/12/2016"}
},
{
"Subject ID":"2850",
"Sample ID":"ms6185-9",
"Factors":{"Time point":"150","Group":"control"},
"Additional sample data":{"Date of study":"5/12/2016"}
},
{
"Subject ID":"2850",
"Sample ID":"ms6185-10",
"Factors":{"Time point":"165","Group":"control"},
"Additional sample data":{"Date of study":"5/12/2016"}
},
{
"Subject ID":"2850",
"Sample ID":"ms6185-11",
"Factors":{"Time point":"180","Group":"control"},
"Additional sample data":{"Date of study":"5/12/2016"}
},
{
"Subject ID":"5908",
"Sample ID":"ms6189-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"5/3/2016"}
},
{
"Subject ID":"5908",
"Sample ID":"ms6189-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"5/4/2016"}
},
{
"Subject ID":"5908",
"Sample ID":"ms6189-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"5/4/2016"}
},
{
"Subject ID":"5908",
"Sample ID":"ms6189-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"5/4/2016"}
},
{
"Subject ID":"5908",
"Sample ID":"ms6189-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"5/4/2016"}
},
{
"Subject ID":"5908",
"Sample ID":"ms6189-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"5/4/2016"}
},
{
"Subject ID":"5908",
"Sample ID":"ms6189-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"5/4/2016"}
},
{
"Subject ID":"5908",
"Sample ID":"ms6189-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"5/4/2016"}
},
{
"Subject ID":"5908",
"Sample ID":"ms6189-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"5/4/2016"}
},
{
"Subject ID":"5908",
"Sample ID":"ms6189-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"5/4/2016"}
},
{
"Subject ID":"5908",
"Sample ID":"ms6189-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"5/4/2016"}
},
{
"Subject ID":"8404",
"Sample ID":"ms6188-1",
"Factors":{"Time point":"baseline","Group":"control"},
"Additional sample data":{"Date of study":"3/282016"}
},
{
"Subject ID":"8404",
"Sample ID":"ms6188-2",
"Factors":{"Time point":"-60","Group":"control"},
"Additional sample data":{"Date of study":"3/30/2016"}
},
{
"Subject ID":"8404",
"Sample ID":"ms6188-3",
"Factors":{"Time point":"-45","Group":"control"},
"Additional sample data":{"Date of study":"3/30/2016"}
},
{
"Subject ID":"8404",
"Sample ID":"ms6188-4",
"Factors":{"Time point":"-30","Group":"control"},
"Additional sample data":{"Date of study":"3/30/2016"}
},
{
"Subject ID":"8404",
"Sample ID":"ms6188-5",
"Factors":{"Time point":"-15","Group":"control"},
"Additional sample data":{"Date of study":"3/30/2016"}
},
{
"Subject ID":"8404",
"Sample ID":"ms6188-6",
"Factors":{"Time point":"60","Group":"control"},
"Additional sample data":{"Date of study":"3/30/2016"}
},
{
"Subject ID":"8404",
"Sample ID":"ms6188-7",
"Factors":{"Time point":"120","Group":"control"},
"Additional sample data":{"Date of study":"3/30/2016"}
},
{
"Subject ID":"8404",
"Sample ID":"ms6188-8",
"Factors":{"Time point":"135","Group":"control"},
"Additional sample data":{"Date of study":"3/30/2016"}
},
{
"Subject ID":"8404",
"Sample ID":"ms6188-9",
"Factors":{"Time point":"150","Group":"control"},
"Additional sample data":{"Date of study":"3/30/2016"}
},
{
"Subject ID":"8404",
"Sample ID":"ms6188-10",
"Factors":{"Time point":"165","Group":"control"},
"Additional sample data":{"Date of study":"3/30/2016"}
},
{
"Subject ID":"8404",
"Sample ID":"ms6188-11",
"Factors":{"Time point":"180","Group":"control"},
"Additional sample data":{"Date of study":"3/30/2016"}
},
{
"Subject ID":"6842",
"Sample ID":"ms6243-1",
"Factors":{"Time point":"baseline","Group":"control"},
"Additional sample data":{"Date of study":"5/26/2016"}
},
{
"Subject ID":"6842",
"Sample ID":"ms6243-2",
"Factors":{"Time point":"-60","Group":"control"},
"Additional sample data":{"Date of study":"5/27/2016"}
},
{
"Subject ID":"6842",
"Sample ID":"ms6243-3",
"Factors":{"Time point":"-45","Group":"control"},
"Additional sample data":{"Date of study":"5/27/2016"}
},
{
"Subject ID":"6842",
"Sample ID":"ms6243-4",
"Factors":{"Time point":"-30","Group":"control"},
"Additional sample data":{"Date of study":"5/27/2016"}
},
{
"Subject ID":"6842",
"Sample ID":"ms6243-5",
"Factors":{"Time point":"-15","Group":"control"},
"Additional sample data":{"Date of study":"5/27/2016"}
},
{
"Subject ID":"6842",
"Sample ID":"ms6243-6",
"Factors":{"Time point":"60","Group":"control"},
"Additional sample data":{"Date of study":"5/27/2016"}
},
{
"Subject ID":"6842",
"Sample ID":"ms6243-7",
"Factors":{"Time point":"120","Group":"control"},
"Additional sample data":{"Date of study":"5/27/2016"}
},
{
"Subject ID":"6842",
"Sample ID":"ms6243-8",
"Factors":{"Time point":"135","Group":"control"},
"Additional sample data":{"Date of study":"5/27/2016"}
},
{
"Subject ID":"6842",
"Sample ID":"ms6243-9",
"Factors":{"Time point":"150","Group":"control"},
"Additional sample data":{"Date of study":"5/27/2016"}
},
{
"Subject ID":"6842",
"Sample ID":"ms6243-10",
"Factors":{"Time point":"165","Group":"control"},
"Additional sample data":{"Date of study":"5/27/2016"}
},
{
"Subject ID":"6842",
"Sample ID":"ms6243-11",
"Factors":{"Time point":"180","Group":"control"},
"Additional sample data":{"Date of study":"5/27/2016"}
},
{
"Subject ID":"6722",
"Sample ID":"ms6275-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"1/28/2016"}
},
{
"Subject ID":"6722",
"Sample ID":"ms6275-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/6/2016"}
},
{
"Subject ID":"6722",
"Sample ID":"ms6275-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/6/2016"}
},
{
"Subject ID":"6722",
"Sample ID":"ms6275-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/6/2016"}
},
{
"Subject ID":"6722",
"Sample ID":"ms6275-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/6/2016"}
},
{
"Subject ID":"6722",
"Sample ID":"ms6275-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/6/2016"}
},
{
"Subject ID":"6722",
"Sample ID":"ms6275-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/6/2016"}
},
{
"Subject ID":"6722",
"Sample ID":"ms6275-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/6/2016"}
},
{
"Subject ID":"6722",
"Sample ID":"ms6275-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/6/2016"}
},
{
"Subject ID":"6722",
"Sample ID":"ms6275-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/6/2016"}
},
{
"Subject ID":"6722",
"Sample ID":"ms6275-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/6/2016"}
},
{
"Subject ID":"9631",
"Sample ID":"ms6183-1",
"Factors":{"Time point":"baseline","Group":"control"},
"Additional sample data":{"Date of study":"3/6/2016"}
},
{
"Subject ID":"9631",
"Sample ID":"ms6183-2",
"Factors":{"Time point":"-60","Group":"control"},
"Additional sample data":{"Date of study":"3/7/2016"}
},
{
"Subject ID":"9631",
"Sample ID":"ms6183-3",
"Factors":{"Time point":"-45","Group":"control"},
"Additional sample data":{"Date of study":"3/7/2016"}
},
{
"Subject ID":"9631",
"Sample ID":"ms6183-4",
"Factors":{"Time point":"-30","Group":"control"},
"Additional sample data":{"Date of study":"3/7/2016"}
},
{
"Subject ID":"9631",
"Sample ID":"ms6183-5",
"Factors":{"Time point":"-15","Group":"control"},
"Additional sample data":{"Date of study":"3/7/2016"}
},
{
"Subject ID":"9631",
"Sample ID":"ms6183-6",
"Factors":{"Time point":"60","Group":"control"},
"Additional sample data":{"Date of study":"3/7/2016"}
},
{
"Subject ID":"9631",
"Sample ID":"ms6183-7",
"Factors":{"Time point":"120","Group":"control"},
"Additional sample data":{"Date of study":"3/7/2016"}
},
{
"Subject ID":"9631",
"Sample ID":"ms6183-8",
"Factors":{"Time point":"135","Group":"control"},
"Additional sample data":{"Date of study":"3/7/2016"}
},
{
"Subject ID":"9631",
"Sample ID":"ms6183-9",
"Factors":{"Time point":"150","Group":"control"},
"Additional sample data":{"Date of study":"3/7/2016"}
},
{
"Subject ID":"9631",
"Sample ID":"ms6183-10",
"Factors":{"Time point":"165","Group":"control"},
"Additional sample data":{"Date of study":"3/7/2016"}
},
{
"Subject ID":"9631",
"Sample ID":"ms6183-11",
"Factors":{"Time point":"180","Group":"control"},
"Additional sample data":{"Date of study":"3/7/2016"}
},
{
"Subject ID":"7725",
"Sample ID":"ms6186-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"3/10/2015"}
},
{
"Subject ID":"7725",
"Sample ID":"ms6186-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"3/11/2015"}
},
{
"Subject ID":"7725",
"Sample ID":"ms6186-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"3/11/2015"}
},
{
"Subject ID":"7725",
"Sample ID":"ms6186-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"3/11/2015"}
},
{
"Subject ID":"7725",
"Sample ID":"ms6186-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"3/11/2015"}
},
{
"Subject ID":"7725",
"Sample ID":"ms6186-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"3/11/2015"}
},
{
"Subject ID":"7725",
"Sample ID":"ms6186-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"3/11/2015"}
},
{
"Subject ID":"7725",
"Sample ID":"ms6186-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"3/11/2015"}
},
{
"Subject ID":"7725",
"Sample ID":"ms6186-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"3/11/2015"}
},
{
"Subject ID":"7725",
"Sample ID":"ms6186-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"3/11/2015"}
},
{
"Subject ID":"7725",
"Sample ID":"ms6186-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"3/11/2015"}
},
{
"Subject ID":"4620",
"Sample ID":"ms6187-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"4/21/2016"}
},
{
"Subject ID":"4620",
"Sample ID":"ms6187-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"4/22/2016"}
},
{
"Subject ID":"4620",
"Sample ID":"ms6187-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"4/22/2016"}
},
{
"Subject ID":"4620",
"Sample ID":"ms6187-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"4/22/2016"}
},
{
"Subject ID":"4620",
"Sample ID":"ms6187-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"4/22/2016"}
},
{
"Subject ID":"4620",
"Sample ID":"ms6187-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"4/22/2016"}
},
{
"Subject ID":"4620",
"Sample ID":"ms6187-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"4/22/2016"}
},
{
"Subject ID":"4620",
"Sample ID":"ms6187-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"4/22/2016"}
},
{
"Subject ID":"4620",
"Sample ID":"ms6187-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"4/22/2016"}
},
{
"Subject ID":"4620",
"Sample ID":"ms6187-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"4/22/2016"}
},
{
"Subject ID":"4620",
"Sample ID":"ms6187-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"4/22/2016"}
},
{
"Subject ID":"3635",
"Sample ID":"ms6100-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"1/12/2016"}
},
{
"Subject ID":"3635",
"Sample ID":"ms6100-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"1/13/2016"}
},
{
"Subject ID":"3635",
"Sample ID":"ms6100-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"1/13/2016"}
},
{
"Subject ID":"3635",
"Sample ID":"ms6100-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"1/13/2016"}
},
{
"Subject ID":"3635",
"Sample ID":"ms6100-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"1/13/2016"}
},
{
"Subject ID":"3635",
"Sample ID":"ms6100-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"1/13/2016"}
},
{
"Subject ID":"3635",
"Sample ID":"ms6100-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"1/13/2016"}
},
{
"Subject ID":"3635",
"Sample ID":"ms6100-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"1/13/2016"}
},
{
"Subject ID":"3635",
"Sample ID":"ms6100-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"1/13/2016"}
},
{
"Subject ID":"3635",
"Sample ID":"ms6100-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"1/13/2016"}
},
{
"Subject ID":"3635",
"Sample ID":"ms6100-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"1/13/2016"}
},
{
"Subject ID":"6737",
"Sample ID":"ms6102-1",
"Factors":{"Time point":"baseline","Group":"control"},
"Additional sample data":{"Date of study":"2/16/2016"}
},
{
"Subject ID":"6737",
"Sample ID":"ms6102-2",
"Factors":{"Time point":"-60","Group":"control"},
"Additional sample data":{"Date of study":"2/17/2016"}
},
{
"Subject ID":"6737",
"Sample ID":"ms6102-3",
"Factors":{"Time point":"-45","Group":"control"},
"Additional sample data":{"Date of study":"2/17/2016"}
},
{
"Subject ID":"6737",
"Sample ID":"ms6102-4",
"Factors":{"Time point":"-30","Group":"control"},
"Additional sample data":{"Date of study":"2/17/2016"}
},
{
"Subject ID":"6737",
"Sample ID":"ms6102-5",
"Factors":{"Time point":"-15","Group":"control"},
"Additional sample data":{"Date of study":"2/17/2016"}
},
{
"Subject ID":"6737",
"Sample ID":"ms6102-6",
"Factors":{"Time point":"60","Group":"control"},
"Additional sample data":{"Date of study":"2/17/2016"}
},
{
"Subject ID":"6737",
"Sample ID":"ms6102-7",
"Factors":{"Time point":"120","Group":"control"},
"Additional sample data":{"Date of study":"2/17/2016"}
},
{
"Subject ID":"6737",
"Sample ID":"ms6102-8",
"Factors":{"Time point":"135","Group":"control"},
"Additional sample data":{"Date of study":"2/17/2016"}
},
{
"Subject ID":"6737",
"Sample ID":"ms6102-9",
"Factors":{"Time point":"150","Group":"control"},
"Additional sample data":{"Date of study":"2/17/2016"}
},
{
"Subject ID":"6737",
"Sample ID":"ms6102-10",
"Factors":{"Time point":"165","Group":"control"},
"Additional sample data":{"Date of study":"2/17/2016"}
},
{
"Subject ID":"6737",
"Sample ID":"ms6102-11",
"Factors":{"Time point":"180","Group":"control"},
"Additional sample data":{"Date of study":"2/17/2016"}
},
{
"Subject ID":"5551",
"Sample ID":"ms6182-1",
"Factors":{"Time point":"baseline","Group":"control"},
"Additional sample data":{"Date of study":"12/13/2016"}
},
{
"Subject ID":"5551",
"Sample ID":"ms6182-2",
"Factors":{"Time point":"-60","Group":"control"},
"Additional sample data":{"Date of study":"12/21/2016"}
},
{
"Subject ID":"5551",
"Sample ID":"ms6182-3",
"Factors":{"Time point":"-45","Group":"control"},
"Additional sample data":{"Date of study":"12/21/2016"}
},
{
"Subject ID":"5551",
"Sample ID":"ms6182-4",
"Factors":{"Time point":"-30","Group":"control"},
"Additional sample data":{"Date of study":"12/21/2016"}
},
{
"Subject ID":"5551",
"Sample ID":"ms6182-5",
"Factors":{"Time point":"-15","Group":"control"},
"Additional sample data":{"Date of study":"12/21/2016"}
},
{
"Subject ID":"5551",
"Sample ID":"ms6182-6",
"Factors":{"Time point":"60","Group":"control"},
"Additional sample data":{"Date of study":"12/21/2016"}
},
{
"Subject ID":"5551",
"Sample ID":"ms6182-7",
"Factors":{"Time point":"120","Group":"control"},
"Additional sample data":{"Date of study":"12/21/2016"}
},
{
"Subject ID":"5551",
"Sample ID":"ms6182-8",
"Factors":{"Time point":"135","Group":"control"},
"Additional sample data":{"Date of study":"12/21/2016"}
},
{
"Subject ID":"5551",
"Sample ID":"ms6182-9",
"Factors":{"Time point":"150","Group":"control"},
"Additional sample data":{"Date of study":"12/21/2016"}
},
{
"Subject ID":"5551",
"Sample ID":"ms6182-10",
"Factors":{"Time point":"165","Group":"control"},
"Additional sample data":{"Date of study":"12/21/2016"}
},
{
"Subject ID":"5551",
"Sample ID":"ms6182-11",
"Factors":{"Time point":"180","Group":"control"},
"Additional sample data":{"Date of study":"12/21/2016"}
},
{
"Subject ID":"5844",
"Sample ID":"ms6034-1",
"Factors":{"Time point":"baseline","Group":"control"},
"Additional sample data":{"Date of study":"1/23/2016"}
},
{
"Subject ID":"5844",
"Sample ID":"ms6034-2",
"Factors":{"Time point":"-60","Group":"control"},
"Additional sample data":{"Date of study":"1/24/2016"}
},
{
"Subject ID":"5844",
"Sample ID":"ms6034-3",
"Factors":{"Time point":"-45","Group":"control"},
"Additional sample data":{"Date of study":"1/24/2016"}
},
{
"Subject ID":"5844",
"Sample ID":"ms6034-4",
"Factors":{"Time point":"-30","Group":"control"},
"Additional sample data":{"Date of study":"1/24/2016"}
},
{
"Subject ID":"5844",
"Sample ID":"ms6034-5",
"Factors":{"Time point":"-15","Group":"control"},
"Additional sample data":{"Date of study":"1/24/2016"}
},
{
"Subject ID":"5844",
"Sample ID":"ms6034-6",
"Factors":{"Time point":"60","Group":"control"},
"Additional sample data":{"Date of study":"1/24/2016"}
},
{
"Subject ID":"5844",
"Sample ID":"ms6034-7",
"Factors":{"Time point":"120","Group":"control"},
"Additional sample data":{"Date of study":"1/24/2016"}
},
{
"Subject ID":"5844",
"Sample ID":"ms6034-8",
"Factors":{"Time point":"135","Group":"control"},
"Additional sample data":{"Date of study":"1/24/2016"}
},
{
"Subject ID":"5844",
"Sample ID":"ms6034-9",
"Factors":{"Time point":"150","Group":"control"},
"Additional sample data":{"Date of study":"1/24/2016"}
},
{
"Subject ID":"5844",
"Sample ID":"ms6034-10",
"Factors":{"Time point":"165","Group":"control"},
"Additional sample data":{"Date of study":"1/24/2016"}
},
{
"Subject ID":"5844",
"Sample ID":"ms6034-11",
"Factors":{"Time point":"180","Group":"control"},
"Additional sample data":{"Date of study":"1/24/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6091-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/16/2015"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6091-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/17/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6091-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/17/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6091-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/17/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6091-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/17/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6091-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/17/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6091-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/17/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6091-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/17/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6091-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/17/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6091-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/17/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6091-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"11/17/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6098-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/22/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6098-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/23/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6098-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/23/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6098-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/23/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6098-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/23/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6098-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/23/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6098-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/23/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6098-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/23/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6098-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/23/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6098-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/23/2016"}
},
{
"Subject ID":"2780",
"Sample ID":"ms6098-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/23/2016"}
},
{
"Subject ID":"8696",
"Sample ID":"ms6036-1",
"Factors":{"Time point":"baseline","Group":"control"},
"Additional sample data":{"Date of study":"1/18/2016"}
},
{
"Subject ID":"8696",
"Sample ID":"ms6036-2",
"Factors":{"Time point":"-60","Group":"control"},
"Additional sample data":{"Date of study":"1/19/2016"}
},
{
"Subject ID":"8696",
"Sample ID":"ms6036-3",
"Factors":{"Time point":"-45","Group":"control"},
"Additional sample data":{"Date of study":"1/19/2016"}
},
{
"Subject ID":"8696",
"Sample ID":"ms6036-4",
"Factors":{"Time point":"-30","Group":"control"},
"Additional sample data":{"Date of study":"1/19/2016"}
},
{
"Subject ID":"8696",
"Sample ID":"ms6036-5",
"Factors":{"Time point":"-15","Group":"control"},
"Additional sample data":{"Date of study":"1/19/2016"}
},
{
"Subject ID":"8696",
"Sample ID":"ms6036-6",
"Factors":{"Time point":"60","Group":"control"},
"Additional sample data":{"Date of study":"1/19/2016"}
},
{
"Subject ID":"8696",
"Sample ID":"ms6036-7",
"Factors":{"Time point":"120","Group":"control"},
"Additional sample data":{"Date of study":"1/19/2016"}
},
{
"Subject ID":"8696",
"Sample ID":"ms6036-8",
"Factors":{"Time point":"135","Group":"control"},
"Additional sample data":{"Date of study":"1/19/2016"}
},
{
"Subject ID":"8696",
"Sample ID":"ms6036-9",
"Factors":{"Time point":"150","Group":"control"},
"Additional sample data":{"Date of study":"1/19/2016"}
},
{
"Subject ID":"8696",
"Sample ID":"ms6036-10",
"Factors":{"Time point":"165","Group":"control"},
"Additional sample data":{"Date of study":"1/19/2016"}
},
{
"Subject ID":"8696",
"Sample ID":"ms6036-11",
"Factors":{"Time point":"180","Group":"control"},
"Additional sample data":{"Date of study":"1/19/2016"}
},
{
"Subject ID":"8999",
"Sample ID":"ms6042-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/15/2015"}
},
{
"Subject ID":"8999",
"Sample ID":"ms6042-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/16/2015"}
},
{
"Subject ID":"8999",
"Sample ID":"ms6042-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/16/2015"}
},
{
"Subject ID":"8999",
"Sample ID":"ms6042-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/16/2015"}
},
{
"Subject ID":"8999",
"Sample ID":"ms6042-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/16/2015"}
},
{
"Subject ID":"8999",
"Sample ID":"ms6042-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/16/2015"}
},
{
"Subject ID":"8999",
"Sample ID":"ms6042-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/16/2015"}
},
{
"Subject ID":"8999",
"Sample ID":"ms6042-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/16/2015"}
},
{
"Subject ID":"8999",
"Sample ID":"ms6042-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/16/2015"}
},
{
"Subject ID":"8999",
"Sample ID":"ms6042-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/16/2015"}
},
{
"Subject ID":"8999",
"Sample ID":"ms6042-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/16/2015"}
},
{
"Subject ID":"7182",
"Sample ID":"ms6099-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/18/2015"}
},
{
"Subject ID":"7182",
"Sample ID":"ms6099-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/19/2015"}
},
{
"Subject ID":"7182",
"Sample ID":"ms6099-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/19/2015"}
},
{
"Subject ID":"7182",
"Sample ID":"ms6099-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/19/2015"}
},
{
"Subject ID":"7182",
"Sample ID":"ms6099-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/19/2015"}
},
{
"Subject ID":"7182",
"Sample ID":"ms6099-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/19/2015"}
},
{
"Subject ID":"7182",
"Sample ID":"ms6099-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/19/2015"}
},
{
"Subject ID":"7182",
"Sample ID":"ms6099-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/19/2015"}
},
{
"Subject ID":"7182",
"Sample ID":"ms6099-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/19/2015"}
},
{
"Subject ID":"7182",
"Sample ID":"ms6099-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/19/2015"}
},
{
"Subject ID":"7182",
"Sample ID":"ms6099-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/19/2015"}
},
{
"Subject ID":"7534",
"Sample ID":"ms6035-1",
"Factors":{"Time point":"baseline","Group":"control"},
"Additional sample data":{"Date of study":"1/25/2016"}
},
{
"Subject ID":"7534",
"Sample ID":"ms6035-2",
"Factors":{"Time point":"-60","Group":"control"},
"Additional sample data":{"Date of study":"1/26/2016"}
},
{
"Subject ID":"7534",
"Sample ID":"ms6035-3",
"Factors":{"Time point":"-45","Group":"control"},
"Additional sample data":{"Date of study":"1/26/2016"}
},
{
"Subject ID":"7534",
"Sample ID":"ms6035-4",
"Factors":{"Time point":"-30","Group":"control"},
"Additional sample data":{"Date of study":"1/26/2016"}
},
{
"Subject ID":"7534",
"Sample ID":"ms6035-5",
"Factors":{"Time point":"-15","Group":"control"},
"Additional sample data":{"Date of study":"1/26/2016"}
},
{
"Subject ID":"7534",
"Sample ID":"ms6035-6",
"Factors":{"Time point":"60","Group":"control"},
"Additional sample data":{"Date of study":"1/26/2016"}
},
{
"Subject ID":"7534",
"Sample ID":"ms6035-7",
"Factors":{"Time point":"120","Group":"control"},
"Additional sample data":{"Date of study":"1/26/2016"}
},
{
"Subject ID":"7534",
"Sample ID":"ms6035-8",
"Factors":{"Time point":"135","Group":"control"},
"Additional sample data":{"Date of study":"1/26/2016"}
},
{
"Subject ID":"7534",
"Sample ID":"ms6035-9",
"Factors":{"Time point":"150","Group":"control"},
"Additional sample data":{"Date of study":"1/26/2016"}
},
{
"Subject ID":"7534",
"Sample ID":"ms6035-10",
"Factors":{"Time point":"165","Group":"control"},
"Additional sample data":{"Date of study":"1/26/2016"}
},
{
"Subject ID":"7534",
"Sample ID":"ms6035-11",
"Factors":{"Time point":"180","Group":"control"},
"Additional sample data":{"Date of study":"1/26/2016"}
},
{
"Subject ID":"3463",
"Sample ID":"ms6038-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/1/2015"}
},
{
"Subject ID":"3463",
"Sample ID":"ms6038-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/2/2015"}
},
{
"Subject ID":"3463",
"Sample ID":"ms6038-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/2/2015"}
},
{
"Subject ID":"3463",
"Sample ID":"ms6038-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/2/2015"}
},
{
"Subject ID":"3463",
"Sample ID":"ms6038-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/2/2015"}
},
{
"Subject ID":"3463",
"Sample ID":"ms6038-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/2/2015"}
},
{
"Subject ID":"3463",
"Sample ID":"ms6038-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/2/2015"}
},
{
"Subject ID":"3463",
"Sample ID":"ms6038-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/2/2015"}
},
{
"Subject ID":"3463",
"Sample ID":"ms6038-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/2/2015"}
},
{
"Subject ID":"3463",
"Sample ID":"ms6038-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/2/2015"}
},
{
"Subject ID":"3463",
"Sample ID":"ms6038-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"12/2/2015"}
},
{
"Subject ID":"6454",
"Sample ID":"ms6101-1",
"Factors":{"Time point":"baseline","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/18/2016"}
},
{
"Subject ID":"6454",
"Sample ID":"ms6101-2",
"Factors":{"Time point":"-60","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/19/2016"}
},
{
"Subject ID":"6454",
"Sample ID":"ms6101-3",
"Factors":{"Time point":"-45","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/19/2016"}
},
{
"Subject ID":"6454",
"Sample ID":"ms6101-4",
"Factors":{"Time point":"-30","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/19/2016"}
},
{
"Subject ID":"6454",
"Sample ID":"ms6101-5",
"Factors":{"Time point":"-15","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/19/2016"}
},
{
"Subject ID":"6454",
"Sample ID":"ms6101-6",
"Factors":{"Time point":"60","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/19/2016"}
},
{
"Subject ID":"6454",
"Sample ID":"ms6101-7",
"Factors":{"Time point":"120","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/19/2016"}
},
{
"Subject ID":"6454",
"Sample ID":"ms6101-8",
"Factors":{"Time point":"135","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/19/2016"}
},
{
"Subject ID":"6454",
"Sample ID":"ms6101-9",
"Factors":{"Time point":"150","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/19/2016"}
},
{
"Subject ID":"6454",
"Sample ID":"ms6101-10",
"Factors":{"Time point":"165","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/19/2016"}
},
{
"Subject ID":"6454",
"Sample ID":"ms6101-11",
"Factors":{"Time point":"180","Group":"PCOS"},
"Additional sample data":{"Date of study":"2/19/2016"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"We will perform a hyperinsulinemic-euglycemic clamp as previously described except that in this current proposal we will perform the study for 3 hours.(36) The goal for this infusion is to assess the effect of hyperinsulinemia on lysine and AAA kinetics and whether metformin changes the effect of hyperinsulinemia. We will collect samples every 10 min for glucose. 40% dextrose will be infused at a variable rate during the clamp to maintain euglycemia.(36) During the last hour of the clamp, 5 blood samples will be drawn for measurement of stable isotope tracer enrichment and amino acid concentrations.","SAMPLE_TYPE":"Blood (plasma)"},

"TREATMENT":{"TREATMENT_SUMMARY":"Ten women with PCOS will receive metformin therapy, and ten women will be randomized to receive no therapy and undergo the same repeat visits after 3 months. Ten age-matched women without PCOS with a BMI < 25 will be recruited as the control group for the baseline visit. Aside from criteria that they do not have PCOS and have a BMI < 25, this control group will have the same inclusion and exclusion criteria below. They will not receive metformin and will not return for repeat visits after 3 months. Metformin therapy: Previous studies with metformin demonstrated improvement in insulin sensitivity as early as 3 months with 1000 mg daily.(5, 33, 34) Metformin will be initiated with 500 mg extended-release tablet daily for one week, 1000 mg daily for one week and then 1500 mg daily. Visits 4 and 5 will be conducted three months after full dose is achieved. Oral glucose tolerance test: After 2 baseline fasting samples, 75 g of oral dextrose will be ingested with blood samples will be drawn at 10’, 20’, 30’, 60’, 90’, 120’, 150’and 180’ for measurement of glucose, insulin, c-peptide. Insulin sensitivity will be calculated using the oral glucose minimal model. Stable isotope tracer infusions (Figure 5): Three days prior to the tracer study, the participants will be placed on a weight-maintaining diet consisting of 50% carbohydrates, 20% protein, and 30% fats. Fat free mass (FFM) measured by dual-energy x-ray absorptiometry will be used for dose calculations of the stable isotope tracers and insulin infusions for the hyperinsulinemic-euglycemic clamp. A priming bolus dose of L-[α-15N]-lysine, 3 to 5 μmol/kg FFM, will be given at the start of a 3 hour infusion of 3 to 5 μmol/kg FFM/hr to achieve a plateau as previously described.(29) At the same time, a priming bolus of 1 to 2 μmol/kg FFM L-[1-13C]-2-aminoadipic acid will be given followed by infusion of 1 to 2 μmol/kg/hr based on prior study.(30) A retrograde hand intravenous line will be placed with the hand placed in a warm box maintained at 140°F to obtain arterialized venous blood samples for measurement of lysine and AAA concentrations and stable isotopic enrichment at steady state and during the clamp. Hyperinsulinemic-euglycemic clamp: We will perform a hyperinsulinemic-euglycemic clamp as previously described except that in this current proposal we will perform the study for 3 hours.(36) The goal for this infusion is to assess the effect of hyperinsulinemia on lysine and AAA kinetics and whether metformin changes the effect of hyperinsulinemia. We will collect samples every 10 min for glucose. 40% dextrose will be infused at a variable rate during the clamp to maintain euglycemia.(36) During the last hour of the clamp, 5 blood samples will be drawn for measurement of stable isotope tracer enrichment and amino acid concentrations."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Plasma lysine and AAA concentrations and isotopic enrichment will be analyzed as previous described via a Thermo Fisher Q Exactive plus mass spectrometer coupled with a Dionex UltiMate 3000 Binary RSLC liquid chromatograph."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Thermo Q Exactive Plus Orbitrap","COLUMN_NAME":"Zorbax Extended C18"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Plus Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"uM"},

"MS_METABOLITE_DATA":{
"Units":"uM",

"Data":[{"Metabolite":"aminoadipic","ms6032-1":"0.796348623","ms6032-2":"0.604570746","ms6032-3":"0.672376869","ms6032-4":"0.621887764","ms6032-5":"0.617913005","ms6032-6":"0.537768957","ms6032-7":"0.385995337","ms6032-8":"0.427876987","ms6032-9":"0.458561028","ms6032-10":"0.422738743","ms6032-11":"0.439988937","ms6039-1":"0.991204736","ms6039-2":"0.854154032","ms6039-3":"0.795969446","ms6039-4":"0.822008498","ms6039-5":"0.87377195","ms6039-6":"0.759062279","ms6039-7":"0.643202218","ms6039-8":"0.688464364","ms6039-9":"0.773270632","ms6039-10":"0.73400765","ms6039-11":"0.752695578","ms6087-1":"1.840604462","ms6087-2":"0.913558589","ms6087-3":"1.235268613","ms6087-4":"0.938289965","ms6087-5":"0.76768043","ms6087-6":"1.138267549","ms6087-7":"0.777074636","ms6087-8":"0.827404535","ms6087-9":"0.829747292","ms6087-10":"0.8001268","ms6087-11":"0.762958849","ms6184-1":"0.920061448","ms6184-2":"0.62479098","ms6184-3":"0.724974718","ms6184-4":"0.631924401","ms6184-5":"0.727648434","ms6184-6":"0.649364028","ms6184-7":"0.703856376","ms6184-8":"0.658278676","ms6184-9":"0.634326489","ms6184-10":"0.601020045","ms6184-11":"0.610416305","ms6185-1":"0.949099181","ms6185-2":"0.647208025","ms6185-3":"0.725787641","ms6185-4":"0.729824438","ms6185-5":"0.69179728","ms6185-6":"0.537856306","ms6185-7":"0.464091291","ms6185-8":"0.551876195","ms6185-9":"0.529687538","ms6185-10":"0.527280744","ms6185-11":"0.479915564","ms6189-1":"1.014967432","ms6189-2":"1.010355299","ms6189-3":"1.0993595","ms6189-4":"0.952976659","ms6189-5":"1.038375589","ms6189-6":"0.886430105","ms6189-7":"0.714939693","ms6189-8":"0.799104616","ms6189-9":"0.74422836","ms6189-10":"0.844481832","ms6189-11":"0.669772077","ms6188-1":"1.071189393","ms6188-2":"0.894442391","ms6188-3":"0.903387259","ms6188-4":"0.887187801","ms6188-5":"0.898341098","ms6188-6":"0.737159165","ms6188-7":"0.725107432","ms6188-8":"0.747131279","ms6188-9":"0.746998488","ms6188-10":"0.780858165","ms6188-11":"0.751341717","ms6243-1":"0.677565653","ms6243-2":"0.668865382","ms6243-3":"0.674667212","ms6243-4":"0.67141215","ms6243-5":"0.730936011","ms6243-6":"0.691328592","ms6243-7":"0.525733759","ms6243-8":"0.6074677","ms6243-9":"0.6327044","ms6243-10":"0.570334317","ms6243-11":"0.61622037","ms6275-1":"1.123117187","ms6275-2":"1.183720563","ms6275-3":"1.004066963","ms6275-4":"1.188586437","ms6275-5":"1.314239089","ms6275-6":"1.040480263","ms6275-7":"0.9458819","ms6275-8":"0.98839828","ms6275-9":"0.962521638","ms6275-10":"0.97490212","ms6275-11":"0.985635925","ms6183-1":"1.035727611","ms6183-2":"0.538984766","ms6183-3":"0.608167241","ms6183-4":"0.522797766","ms6183-5":"0.531897915","ms6183-6":"0.501004913","ms6183-7":"0.442379004","ms6183-8":"0.453407219","ms6183-9":"0.477157429","ms6183-10":"0.439631582","ms6183-11":"0.451381797","ms6186-1":"1.843419205","ms6186-2":"0.987028705","ms6186-3":"0.966921009","ms6186-4":"0.95988011","ms6186-5":"0.984540145","ms6186-6":"0.922798351","ms6186-7":"0.862319834","ms6186-8":"0.846878919","ms6186-9":"0.834478084","ms6186-10":"0.821167026","ms6186-11":"0.874215437","ms6187-1":"2.00910533","ms6187-2":"1.207550514","ms6187-3":"1.129586626","ms6187-4":"0.957867343","ms6187-5":"1.072927064","ms6187-6":"0.730689834","ms6187-7":"0.641617059","ms6187-8":"0.566761507","ms6187-9":"0.703398651","ms6187-10":"0.661484048","ms6187-11":"0.734551476","ms6100-1":"0.73525948","ms6100-2":"0.469497998","ms6100-3":"0.565447713","ms6100-4":"0.511197093","ms6100-5":"0.530293285","ms6100-6":"0.545587161","ms6100-7":"0.442868352","ms6100-8":"0.491789255","ms6100-9":"0.486451288","ms6100-10":"0.452878622","ms6100-11":"0.414890643","ms6102-1":"1.498435801","ms6102-2":"1.059607443","ms6102-3":"1.027136328","ms6102-4":"1.112322875","ms6102-5":"0.977313802","ms6102-6":"0.888689994","ms6102-7":"0.749966134","ms6102-8":"0.857904564","ms6102-9":"0.800514571","ms6102-10":"0.75531117","ms6102-11":"0.630696146","ms6182-1":"0.480307002","ms6182-2":"0.439720876","ms6182-3":"0.462550342","ms6182-4":"0.494318549","ms6182-5":"0.460362648","ms6182-6":"0.458831457","ms6182-7":"0.426135442","ms6182-8":"0.426095035","ms6182-9":"0.459008564","ms6182-10":"0.381508698","ms6182-11":"0.428449403","ms6034-1":"0.730527295","ms6034-2":"0.496465817","ms6034-3":"0.617696346","ms6034-4":"0.606855583","ms6034-5":"0.592497465","ms6034-6":"0.523824441","ms6034-7":"0.4359921","ms6034-8":"0.463873194","ms6034-9":"0.511983251","ms6034-10":"0.560860626","ms6034-11":"0.490130742","ms6091-1":"1.13834371","ms6091-2":"1.125206776","ms6091-3":"1.081010653","ms6091-4":"1.047141191","ms6091-5":"1.112171827","ms6091-6":"0.867599924","ms6091-7":"0.740627048","ms6091-8":"0.827529202","ms6091-9":"0.769744566","ms6091-10":"0.785981458","ms6091-11":"0.945949562","ms6098-1":"0.786922014","ms6098-2":"0.949436108","ms6098-3":"0.857549749","ms6098-4":"0.964113688","ms6098-5":"0.997211638","ms6098-6":"0.88403397","ms6098-7":"0.826462202","ms6098-8":"0.853739817","ms6098-9":"0.716340061","ms6098-10":"0.80531341","ms6098-11":"0.797994769","ms6036-1":"1.001109026","ms6036-2":"0.717346201","ms6036-3":"0.751881137","ms6036-4":"0.933907136","ms6036-5":"0.902004478","ms6036-6":"0.630211508","ms6036-7":"0.644538592","ms6036-8":"0.591129095","ms6036-9":"0.589644882","ms6036-10":"0.562438734","ms6036-11":"0.549171731","ms6042-1":"1.06108067","ms6042-2":"0.849810873","ms6042-3":"0.95659327","ms6042-4":"1.044703265","ms6042-5":"0.975841423","ms6042-6":"1.437895841","ms6042-7":"0.693929686","ms6042-8":"0.742120466","ms6042-9":"0.766288331","ms6042-10":"0.733354655","ms6042-11":"0.772107454","ms6099-1":"0.913314859","ms6099-2":"0.676768541","ms6099-3":"0.766368946","ms6099-4":"0.774691472","ms6099-5":"0.752027609","ms6099-6":"0.740467796","ms6099-7":"0.655687421","ms6099-8":"0.632202267","ms6099-9":"0.806351442","ms6099-10":"0.723313744","ms6099-11":"1.03494968","ms6035-1":"0.542780452","ms6035-2":"0.364439274","ms6035-3":"0.388040649","ms6035-4":"0.408110814","ms6035-5":"0.435302612","ms6035-6":"0.351266938","ms6035-7":"0.320531022","ms6035-8":"0.331398433","ms6035-9":"0.328802693","ms6035-10":"0.359567398","ms6035-11":"0.398607211","ms6038-1":"0.951180735","ms6038-2":"0.80756324","ms6038-3":"0.769363439","ms6038-4":"0.731059607","ms6038-5":"0.664876157","ms6038-6":"0.744068543","ms6038-7":"0.558247778","ms6038-8":"0.523892284","ms6038-9":"0.550174452","ms6038-10":"0.503926422","ms6038-11":"0.573329551","ms6101-1":"0.678924948","ms6101-2":"0.409422099","ms6101-3":"0.473547175","ms6101-4":"0.4417022","ms6101-5":"0.490483534","ms6101-6":"0.333965992","ms6101-7":"0.430175348","ms6101-8":"0.400931418","ms6101-9":"0.35161662","ms6101-10":"0.414678813","ms6101-11":"0.420628396"},{"Metabolite":"Lysine","ms6032-1":"149.5377529","ms6032-2":"117.9064001","ms6032-3":"122.5737378","ms6032-4":"120.5620532","ms6032-5":"111.7072986","ms6032-6":"98.29875289","ms6032-7":"93.36273611","ms6032-8":"91.79254216","ms6032-9":"91.66831734","ms6032-10":"90.45844285","ms6032-11":"98.15333098","ms6039-1":"161.0064174","ms6039-2":"162.3173526","ms6039-3":"174.5889869","ms6039-4":"166.3746924","ms6039-5":"159.648098","ms6039-6":"152.2171483","ms6039-7":"136.9231115","ms6039-8":"146.9545379","ms6039-9":"157.6357425","ms6039-10":"149.374604","ms6039-11":"147.4914673","ms6087-1":"249.8976348","ms6087-2":"175.7549533","ms6087-3":"184.8437705","ms6087-4":"168.4614102","ms6087-5":"175.928","ms6087-6":"183.5173475","ms6087-7":"166.1992467","ms6087-8":"168.3259592","ms6087-9":"164.100999","ms6087-10":"170.2130073","ms6087-11":"160.2691045","ms6184-1":"157.2226796","ms6184-2":"132.0091442","ms6184-3":"135.0672571","ms6184-4":"137.4921514","ms6184-5":"194.181425","ms6184-6":"139.309324","ms6184-7":"122.038638","ms6184-8":"136.2563781","ms6184-9":"135.0138777","ms6184-10":"133.4063117","ms6184-11":"129.9317204","ms6185-1":"269.8837932","ms6185-2":"166.6484115","ms6185-3":"172.1792155","ms6185-4":"172.4914372","ms6185-5":"167.5662598","ms6185-6":"130.173713","ms6185-7":"114.2159288","ms6185-8":"147.6203244","ms6185-9":"117.5603816","ms6185-10":"122.9840458","ms6185-11":"111.4540595","ms6189-1":"162.6382342","ms6189-2":"174.4122251","ms6189-3":"195.0150993","ms6189-4":"182.3710262","ms6189-5":"182.0862126","ms6189-6":"164.0327947","ms6189-7":"175.6653829","ms6189-8":"179.9787242","ms6189-9":"181.4087156","ms6189-10":"175.8998304","ms6189-11":"154.0460212","ms6188-1":"233.9430023","ms6188-2":"208.9615783","ms6188-3":"215.4735566","ms6188-4":"196.9130175","ms6188-5":"199.3601604","ms6188-6":"190.5205959","ms6188-7":"195.7716597","ms6188-8":"199.1284988","ms6188-9":"198.8807605","ms6188-10":"209.3318868","ms6188-11":"181.9514165","ms6243-1":"199.7487283","ms6243-2":"168.3117795","ms6243-3":"160.4916746","ms6243-4":"161.3529875","ms6243-5":"161.2066384","ms6243-6":"166.9230955","ms6243-7":"142.9851964","ms6243-8":"162.6908797","ms6243-9":"155.2701159","ms6243-10":"153.2755893","ms6243-11":"148.3563846","ms6275-1":"189.5773393","ms6275-2":"226.6723017","ms6275-3":"175.4888635","ms6275-4":"221.8727512","ms6275-5":"215.1606539","ms6275-6":"200.1582713","ms6275-7":"175.7053849","ms6275-8":"197.963596","ms6275-9":"184.9354817","ms6275-10":"192.8955376","ms6275-11":"189.6698835","ms6183-1":"171.4928085","ms6183-2":"142.5789184","ms6183-3":"152.7515088","ms6183-4":"157.7551663","ms6183-5":"131.0643829","ms6183-6":"122.0960264","ms6183-7":"121.0217718","ms6183-8":"121.302109","ms6183-9":"137.5768559","ms6183-10":"130.688678","ms6183-11":"130.8932365","ms6186-1":"288.1799201","ms6186-2":"205.1478765","ms6186-3":"208.4012071","ms6186-4":"195.719947","ms6186-5":"194.4355227","ms6186-6":"178.5198421","ms6186-7":"173.872975","ms6186-8":"164.9627836","ms6186-9":"177.1890491","ms6186-10":"168.324518","ms6186-11":"170.5304878","ms6187-1":"312.3078224","ms6187-2":"263.4078113","ms6187-3":"239.2777259","ms6187-4":"221.6098959","ms6187-5":"245.75333","ms6187-6":"147.7117935","ms6187-7":"154.4971132","ms6187-8":"134.7554411","ms6187-9":"153.1040371","ms6187-10":"159.6145546","ms6187-11":"151.660076","ms6100-1":"157.0377327","ms6100-2":"152.7724311","ms6100-3":"152.9166093","ms6100-4":"149.6306084","ms6100-5":"160.3903206","ms6100-6":"159.0478333","ms6100-7":"132.1515136","ms6100-8":"145.9946824","ms6100-9":"140.0361849","ms6100-10":"125.6737572","ms6100-11":"124.0282636","ms6102-1":"183.3252846","ms6102-2":"150.1515449","ms6102-3":"148.5682971","ms6102-4":"146.8634681","ms6102-5":"143.4223189","ms6102-6":"131.0242765","ms6102-7":"119.7478576","ms6102-8":"135.0273892","ms6102-9":"128.90442","ms6102-10":"116.0929378","ms6102-11":"98.02609493","ms6182-1":"110.9399815","ms6182-2":"139.7987904","ms6182-3":"130.2279939","ms6182-4":"136.9631633","ms6182-5":"129.1155705","ms6182-6":"121.2986671","ms6182-7":"118.3225341","ms6182-8":"112.2439791","ms6182-9":"114.3217371","ms6182-10":"107.5648812","ms6182-11":"112.5838133","ms6034-1":"235.0516861","ms6034-2":"170.0338899","ms6034-3":"164.0537739","ms6034-4":"155.583044","ms6034-5":"155.2704437","ms6034-6":"144.8778302","ms6034-7":"131.2675091","ms6034-8":"138.9350946","ms6034-9":"135.2913719","ms6034-10":"137.4506561","ms6034-11":"134.5358766","ms6091-1":"272.6554991","ms6091-2":"213.5202132","ms6091-3":"214.7632326","ms6091-4":"194.5914671","ms6091-5":"206.1168164","ms6091-6":"178.4508469","ms6091-7":"170.9154406","ms6091-8":"175.6496605","ms6091-9":"179.2101086","ms6091-10":"161.7794197","ms6091-11":"188.8405411","ms6098-1":"198.3589186","ms6098-2":"205.7323669","ms6098-3":"202.5242589","ms6098-4":"213.3546528","ms6098-5":"196.8664401","ms6098-6":"203.0880608","ms6098-7":"190.1637387","ms6098-8":"183.5076516","ms6098-9":"188.5326847","ms6098-10":"187.8042684","ms6098-11":"172.5239615","ms6036-1":"220.0497013","ms6036-2":"157.4296064","ms6036-3":"159.450557","ms6036-4":"154.9649172","ms6036-5":"171.249989","ms6036-6":"143.5301715","ms6036-7":"142.0979694","ms6036-8":"146.227152","ms6036-9":"143.7447363","ms6036-10":"136.283229","ms6036-11":"117.3368473","ms6042-1":"268.2620733","ms6042-2":"234.2722199","ms6042-3":"222.4450242","ms6042-4":"236.6058678","ms6042-5":"235.2444041","ms6042-6":"229.1832831","ms6042-7":"209.6360445","ms6042-8":"217.4643081","ms6042-9":"219.4419255","ms6042-10":"219.4364106","ms6042-11":"216.7519543","ms6099-1":"255.6287773","ms6099-2":"190.3639452","ms6099-3":"192.9273175","ms6099-4":"188.8891048","ms6099-5":"187.2133016","ms6099-6":"165.1593941","ms6099-7":"165.2564077","ms6099-8":"157.7702704","ms6099-9":"165.458329","ms6099-10":"178.7492423","ms6099-11":"175.846359","ms6035-1":"131.1976883","ms6035-2":"137.3494181","ms6035-3":"135.5927176","ms6035-4":"134.6259428","ms6035-5":"144.5988827","ms6035-6":"112.8383996","ms6035-7":"107.87097","ms6035-8":"110.6800278","ms6035-9":"111.0024921","ms6035-10":"112.1949335","ms6035-11":"108.7901802","ms6038-1":"254.3027138","ms6038-2":"219.7497552","ms6038-3":"203.0193943","ms6038-4":"190.8538147","ms6038-5":"203.7134366","ms6038-6":"199.9627726","ms6038-7":"180.7018149","ms6038-8":"176.0771932","ms6038-9":"172.0806703","ms6038-10":"182.0096582","ms6038-11":"182.3281344","ms6101-1":"200.2888253","ms6101-2":"113.1422894","ms6101-3":"130.1528003","ms6101-4":"134.8066294","ms6101-5":"132.1084824","ms6101-6":"98.05126955","ms6101-7":"116.3864056","ms6101-8":"110.4243381","ms6101-9":"111.5182732","ms6101-10":"118.3528926","ms6101-11":"110.0925443"}],

"Metabolites":[{"metabolite_name":"aminoadipic"},{"metabolite_name":"Lysine"}]
}

}