{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001060","ANALYSIS_ID":"AN001730","VERSION":"1","CREATED_ON":"September 21, 2018, 3:09 pm"},

"PROJECT":{"PROJECT_TITLE":"Multi-omics Approach Reveals Metabolic Changes in the Heart at Birth","PROJECT_SUMMARY":"During late gestation, the fetal heart primarily relies on glucose and lactate to support rapid growth and development. While numerous studies describe changes in heart metabolism a few weeks after birth to preferentially utilize fatty acids, little is known about metabolic changes of the heart within the first day following birth. Therefore, we used the ovine model of pregnancy to investigate metabolic differences between the near-term fetal and the newborn heart. Samples were collected for metabolomic, lipidomic, and transcriptomic approaches from the left and right ventricles and intraventricular septum in 7 fetuses at gestational day 142 and 7 newborn lambs on the day of birth. We observed greater abundance of metabolites involved in butanoate and propanoate metabolism, and glycolysis in the term fetal heart (FDR-corrected p<0.10) and differential expression in these pathways were confirmed with single-sample gene set enrichment analysis (ssGSEA) (FDR-corrected p<0.05). Immediately following birth, newborn hearts displayed enrichment in purine, fatty acid, and glycerophospholipid metabolic pathways, as well as oxidative phosphorylation with significant alterations in both lipids and metabolites to support transcriptomic findings. While other studies suggest a switch from carbohydrate metabolism to fatty acid metabolism in the neonatal heart in as early as 2 weeks following birth, our data show that this metabolic switch in the heart begins by the first day of postnatal life. A better understanding of metabolic alterations that occur in the heart following birth may improve treatment of neonates at risk for heart failure.","INSTITUTE":"University of Florida","DEPARTMENT":"Pharmacodynamics","LAST_NAME":"Keller-Wood","FIRST_NAME":"Maureen","ADDRESS":"1345 SW Archer Rd, PO 100487, Gainesville, FL, 32610","EMAIL":"kellerwd@cop.ufl.edu","PHONE":"NA"},

"STUDY":{"STUDY_TITLE":"NMR Metabolomics of Near-Term Fetal and Newborn Sheep Cardiac Tissue (part-I)","STUDY_TYPE":"Comparison","STUDY_SUMMARY":"Cardiac tissue from near-term fetal and newborn sheep were compared via NMR metabolomic analysis","INSTITUTE":"University of Florida","DEPARTMENT":"Biochemistry & Molecular Biology","LAST_NAME":"Walejko","FIRST_NAME":"Jacquelyn","ADDRESS":"R3-226 Academic Research Building, Department of Biochemistry and Molecular Biology, PO Box 100245, Gainesville, FL 32610-0245","EMAIL":"jwalejko@ufl.edu","PHONE":"na","NUM_GROUPS":"2","TOTAL_SUBJECTS":"41"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Ovis aries","TAXONOMY_ID":"9940","AGE_OR_AGE_RANGE":"142 days gestation (fetal); Within 24 hours of birth (newborn)"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"1477",
"Sample ID":"1477_LV",
"Factors":{"Age":"Newborn","Area_heart":"Left_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"70"}
},
{
"Subject ID":"5562C",
"Sample ID":"5562C_RV",
"Factors":{"Age":"Newborn","Area_heart":"Right_ventricle","Sex":"Female"},
"Additional sample data":{"NMR_ID":"73"}
},
{
"Subject ID":"1481",
"Sample ID":"1481_S",
"Factors":{"Age":"Fetal","Area_heart":"Septum","Sex":"Female"},
"Additional sample data":{"NMR_ID":"74"}
},
{
"Subject ID":"1767A",
"Sample ID":"1767A_LV",
"Factors":{"Age":"Newborn","Area_heart":"Left_ventricle","Sex":"Female"},
"Additional sample data":{"NMR_ID":"75"}
},
{
"Subject ID":"5562A",
"Sample ID":"5562A_S",
"Factors":{"Age":"Newborn","Area_heart":"Septum","Sex":"Female"},
"Additional sample data":{"NMR_ID":"76"}
},
{
"Subject ID":"1335A",
"Sample ID":"1335A_S",
"Factors":{"Age":"Fetal","Area_heart":"Septum","Sex":"Male"},
"Additional sample data":{"NMR_ID":"77"}
},
{
"Subject ID":"1335B",
"Sample ID":"1335B_LV",
"Factors":{"Age":"Fetal","Area_heart":"Left_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"81"}
},
{
"Subject ID":"1237A",
"Sample ID":"1237A_RV",
"Factors":{"Age":"Fetal","Area_heart":"Right_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"82"}
},
{
"Subject ID":"1237B",
"Sample ID":"1237B_LV",
"Factors":{"Age":"Fetal","Area_heart":"Left_ventricle","Sex":"Female"},
"Additional sample data":{"NMR_ID":"83"}
},
{
"Subject ID":"1767B",
"Sample ID":"1767B_S",
"Factors":{"Age":"Newborn","Area_heart":"Septum","Sex":"Female"},
"Additional sample data":{"NMR_ID":"84"}
},
{
"Subject ID":"5562B",
"Sample ID":"5562B_RV",
"Factors":{"Age":"Newborn","Area_heart":"Right_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"85"}
},
{
"Subject ID":"1335A",
"Sample ID":"1335A_LV",
"Factors":{"Age":"Fetal","Area_heart":"Left_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"86"}
},
{
"Subject ID":"1555A",
"Sample ID":"1555A_RV",
"Factors":{"Age":"Fetal","Area_heart":"Right_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"87"}
},
{
"Subject ID":"1562A",
"Sample ID":"1562A_S",
"Factors":{"Age":"Fetal","Area_heart":"Septum","Sex":"Male"},
"Additional sample data":{"NMR_ID":"88"}
},
{
"Subject ID":"5562C",
"Sample ID":"5562C_LV",
"Factors":{"Age":"Newborn","Area_heart":"Left_ventricle","Sex":"Female"},
"Additional sample data":{"NMR_ID":"89"}
},
{
"Subject ID":"5562B",
"Sample ID":"5562B_LV",
"Factors":{"Age":"Newborn","Area_heart":"Left_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"90"}
},
{
"Subject ID":"1767B",
"Sample ID":"1767B_LV",
"Factors":{"Age":"Newborn","Area_heart":"Left_ventricle","Sex":"Female"},
"Additional sample data":{"NMR_ID":"91"}
},
{
"Subject ID":"1767A",
"Sample ID":"1767A_S",
"Factors":{"Age":"Newborn","Area_heart":"Septum","Sex":"Female"},
"Additional sample data":{"NMR_ID":"92"}
},
{
"Subject ID":"1462",
"Sample ID":"1462_RV",
"Factors":{"Age":"Newborn","Area_heart":"Right_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"94"}
},
{
"Subject ID":"5562A",
"Sample ID":"5562A_RV",
"Factors":{"Age":"Newborn","Area_heart":"Right_ventricle","Sex":"Female"},
"Additional sample data":{"NMR_ID":"96"}
},
{
"Subject ID":"1462",
"Sample ID":"1462_S",
"Factors":{"Age":"Newborn","Area_heart":"Septum","Sex":"Male"},
"Additional sample data":{"NMR_ID":"97"}
},
{
"Subject ID":"1555A",
"Sample ID":"1555A_LV",
"Factors":{"Age":"Fetal","Area_heart":"Left_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"98"}
},
{
"Subject ID":"1237B",
"Sample ID":"1237B_S",
"Factors":{"Age":"Fetal","Area_heart":"Septum","Sex":"Female"},
"Additional sample data":{"NMR_ID":"99"}
},
{
"Subject ID":"1767B",
"Sample ID":"1767B_RV",
"Factors":{"Age":"Newborn","Area_heart":"Right_ventricle","Sex":"Female"},
"Additional sample data":{"NMR_ID":"100"}
},
{
"Subject ID":"1462",
"Sample ID":"1462_LV",
"Factors":{"Age":"Newborn","Area_heart":"Left_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"101"}
},
{
"Subject ID":"1562A",
"Sample ID":"1562A_RV",
"Factors":{"Age":"Fetal","Area_heart":"Right_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"102"}
},
{
"Subject ID":"1335A",
"Sample ID":"1335A_RV",
"Factors":{"Age":"Fetal","Area_heart":"Right_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"103"}
},
{
"Subject ID":"1562A",
"Sample ID":"1562A_LV",
"Factors":{"Age":"Fetal","Area_heart":"Left_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"104"}
},
{
"Subject ID":"5562C",
"Sample ID":"5562C_S",
"Factors":{"Age":"Newborn","Area_heart":"Septum","Sex":"Female"},
"Additional sample data":{"NMR_ID":"105"}
},
{
"Subject ID":"1767A",
"Sample ID":"1767A_RV",
"Factors":{"Age":"Newborn","Area_heart":"Right_ventricle","Sex":"Female"},
"Additional sample data":{"NMR_ID":"106"}
},
{
"Subject ID":"1237A",
"Sample ID":"1237A_S",
"Factors":{"Age":"Fetal","Area_heart":"Septum","Sex":"Male"},
"Additional sample data":{"NMR_ID":"107"}
},
{
"Subject ID":"1481",
"Sample ID":"1481_LV",
"Factors":{"Age":"Fetal","Area_heart":"Left_ventricle","Sex":"Female"},
"Additional sample data":{"NMR_ID":"108"}
},
{
"Subject ID":"1335B",
"Sample ID":"1335B_S",
"Factors":{"Age":"Fetal","Area_heart":"Septum","Sex":"Male"},
"Additional sample data":{"NMR_ID":"109"}
},
{
"Subject ID":"1477",
"Sample ID":"1477B_RV",
"Factors":{"Age":"Newborn","Area_heart":"Right_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"110"}
},
{
"Subject ID":"1477",
"Sample ID":"1477B_S",
"Factors":{"Age":"Newborn","Area_heart":"Septum","Sex":"Male"},
"Additional sample data":{"NMR_ID":"111"}
},
{
"Subject ID":"5562B",
"Sample ID":"5562B_S",
"Factors":{"Age":"Newborn","Area_heart":"Septum","Sex":"Male"},
"Additional sample data":{"NMR_ID":"112"}
},
{
"Subject ID":"1481",
"Sample ID":"1481_RV",
"Factors":{"Age":"Fetal","Area_heart":"Right_ventricle","Sex":"Female"},
"Additional sample data":{"NMR_ID":"113"}
},
{
"Subject ID":"1237B",
"Sample ID":"1237B_RV",
"Factors":{"Age":"Fetal","Area_heart":"Right_ventricle","Sex":"Female"},
"Additional sample data":{"NMR_ID":"114"}
},
{
"Subject ID":"5562A",
"Sample ID":"5562A_LV",
"Factors":{"Age":"Newborn","Area_heart":"Left_ventricle","Sex":"Female"},
"Additional sample data":{"NMR_ID":"115"}
},
{
"Subject ID":"1237A",
"Sample ID":"1237A_LV",
"Factors":{"Age":"Fetal","Area_heart":"Left_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"116"}
},
{
"Subject ID":"1335B",
"Sample ID":"1335B_RV",
"Factors":{"Age":"Fetal","Area_heart":"Right_ventricle","Sex":"Male"},
"Additional sample data":{"NMR_ID":"117"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Ewes were assigned to one of two groups: (1) a fetal group (n=7, 3 singleton and 2 multiple gestation pregnancies); (2) a newborn group (n=7, 2 singleton and 2 multiple gestation pregnancies). Heart tissue was collected from the right ventricle (RV), left ventricle (LV), and intraventricular septum (IVS) on the day of birth (newborn group) or at gestational day 142 (fetal group) and immediately frozen in liquid nitrogen. Samples were stored at -80 °C until data collection.","SAMPLE_TYPE":"Cardiac tissue","COLLECTION_METHOD":"Heart tissue was collected under sterile conditions and immediately frozen in liquid nitrogen","COLLECTION_LOCATION":"University of Florida","STORAGE_CONDITIONS":"-80℃","COLLECTION_VIALS":"Cryovials","STORAGE_VIALS":"Cryovials"},

"TREATMENT":{"TREATMENT_SUMMARY":"NA"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Heart tissue (20-50 mg) was cut and weighed on dry ice before being placed on a sterile agar plate. Thirty μL of deuterium oxide (D2O) was added to each tissue sample before being placed in a 4 mm HR-MAS rotor (Bruker Biospin, Billerica, MA, USA) and leftover D2O (from original 30 μL) was added to the rotor with a pipette after placement of tissue. The samples were kept on dry ice until data acquisition."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"-","INSTRUMENT_NAME":"-","COLUMN_NAME":"-"},

"ANALYSIS":{"ACQUISITION_DATE":"Aug-16","ANALYSIS_TYPE":"NMR"},

"NM":{"INSTRUMENT_NAME":"Bruker Avance III","INSTRUMENT_TYPE":"FT-NMR","NMR_EXPERIMENT_TYPE":"1D-1H","FIELD_FREQUENCY_LOCK":"H2O+D2O","SPECTROMETER_FREQUENCY":"600 MHz","NMR_PROBE":"4mm HR-MAS","NMR_SOLVENT":"D2O","NMR_TUBE_SIZE":"4mm HRMAS rotor","SHIMMING_METHOD":"Topshim","PULSE_SEQUENCE":"noesypr1d","WATER_SUPPRESSION":"Presaturation","POWER_LEVEL":"18 W","RECEIVER_GAIN":"40.3","OFFSET_FREQUENCY":"2819.74","PRESATURATION_POWER_LEVEL":"3.98E-05","TEMPERATURE":"4C","NUMBER_OF_SCANS":"128","DUMMY_SCANS":"8","ACQUISITION_TIME":"1.3598 sec","RELAXATION_DELAY":"2 sec","SPECTRAL_WIDTH":"10.0155 ppm","NUM_DATA_POINTS_ACQUIRED":"16344","REAL_DATA_POINTS":"32768","LINE_BROADENING":"2","APODIZATION":"Exponential","BASELINE_CORRECTION_METHOD":"Polynomial order 5"},

"NMR_METABOLITE_DATA":{
"Units":"Area under the curve",

"Data":[{"Metabolite":"Lipid 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}

}