{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001107","ANALYSIS_ID":"AN001801","VERSION":"1","CREATED_ON":"December 5, 2018, 12:06 pm"},

"PROJECT":{"PROJECT_TITLE":"Chronic Maternal Cortisol Excess During Late Gestation Leads to Metabolic Alterations in the Newborn Heart","PROJECT_SUMMARY":"Our laboratory has previously shown in an ovine model of pregnancy that abnormal elevations in maternal cortisol during late gestation lead to increased fetal cardiac arrhythmias and mortality during peripartum. Furthermore, transcriptomic analysis of the fetal heart suggested alterations in TCA cycle intermediates and lipid metabolites in animals exposed to excess cortisol in utero. Therefore, we utilized a sheep model of pregnancy to determine how chronic increases in maternal cortisol alter maternal and fetal serum prior to birth and neonatal cardiac metabolites and lipids at term. Ewes were either infused with 1 mg/kg/day of cortisol starting at gestational day 115 (n=9), or untreated (n=6). Serum was collected from the mother and fetus (125 d-birth), and hearts were collected following birth. Proton nuclear magnetic resonance (1H-NMR) spectroscopy was conducted to measure metabolic profiles of newborn heart specimens as well as fetal and maternal serum specimens. Mass spectrometry was conducted to measure lipid profiles of newborn heart specimens. We observed alterations in amino acid and TCA cycle metabolism as well as lipid and glycerophospholipid metabolism in newborn hearts after excess maternal cortisol in late gestation. In addition, we observed alterations in amino acid and TCA cycle metabolites in fetal but not in maternal serum during late gestation. These results suggest that fetal exposure to excess maternal cortisol alters placental and fetal metabolism prior to birth and limits normal cardiac metabolic maturation, which may contribute to increased risk of peripartum cardiac arrhythmias observed in these animals, or later life cardiomyopathies.","INSTITUTE":"University of Florida","LAST_NAME":"Keller-Wood","FIRST_NAME":"Maureen","ADDRESS":"1345 SW Archer Rd, PO 100487, Gainesville, FL, 32610","EMAIL":"kellerwd@cop.ufl.edu","PHONE":"na"},

"STUDY":{"STUDY_TITLE":"NMR Metabolomics of Newborn Heart Tissue Exposed to Excess Maternal Cortisol in Late Gestation (part -II)","STUDY_TYPE":"Comparison","STUDY_SUMMARY":"Cardiac tissue from newborn hearts from animals exposed to excess maternal cortisol in late gestation and untreated was compared via NMR metabolomic analysis","INSTITUTE":"University of Florida","DEPARTMENT":"Biochemsitry & Molecular Biology","LAST_NAME":"Walejko","FIRST_NAME":"Jacquelyn","ADDRESS":"R3-226 Academic Research Building, Department of Biochemistry and Molecular Biology, PO Box 100245, Gainesville, FL 32610-0245","EMAIL":"jwalejko@uga.edu","PHONE":"NA","NUM_GROUPS":"2","TOTAL_SUBJECTS":"36"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Ovis aries","TAXONOMY_ID":"9940","AGE_OR_AGE_RANGE":"Within 6 hours of birth"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"717",
"Sample ID":"717_LV",
"Factors":{"Treatment":"Cortisol","Heart Area":"Left_ventricle"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"3843",
"Sample ID":"3843_RV",
"Factors":{"Treatment":"Cortisol","Heart Area":"Right_ventricle"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"717",
"Sample ID":"717_RV",
"Factors":{"Treatment":"Cortisol","Heart Area":"Right_ventricle"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"3843",
"Sample ID":"3843_LV",
"Factors":{"Treatment":"Cortisol","Heart Area":"Left_ventricle"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"3843",
"Sample ID":"3843_S",
"Factors":{"Treatment":"Cortisol","Heart Area":"Septum"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"717",
"Sample ID":"717_S",
"Factors":{"Treatment":"Cortisol","Heart Area":"Septum"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"753",
"Sample ID":"753_S",
"Factors":{"Treatment":"Control","Heart Area":"Septum"},
"Additional sample data":{"Batch":"2"}
},
{
"Subject ID":"767",
"Sample ID":"767_S",
"Factors":{"Treatment":"Control","Heart Area":"Septum"},
"Additional sample data":{"Batch":"2"}
},
{
"Subject ID":"753",
"Sample ID":"753_LV",
"Factors":{"Treatment":"Control","Heart Area":"Left_ventricle"},
"Additional sample data":{"Batch":"2"}
},
{
"Subject ID":"767",
"Sample ID":"767_LV",
"Factors":{"Treatment":"Control","Heart Area":"Left_ventricle"},
"Additional sample data":{"Batch":"2"}
},
{
"Subject ID":"802",
"Sample ID":"802_S",
"Factors":{"Treatment":"Cortisol","Heart Area":"Septum"},
"Additional sample data":{"Batch":"2"}
},
{
"Subject ID":"753",
"Sample ID":"753_RV",
"Factors":{"Treatment":"Control","Heart Area":"Right_ventricle"},
"Additional sample data":{"Batch":"2"}
},
{
"Subject ID":"767",
"Sample ID":"767_RV",
"Factors":{"Treatment":"Control","Heart Area":"Right_ventricle"},
"Additional sample data":{"Batch":"2"}
},
{
"Subject ID":"802",
"Sample ID":"802_RV",
"Factors":{"Treatment":"Cortisol","Heart Area":"Right_ventricle"},
"Additional sample data":{"Batch":"2"}
},
{
"Subject ID":"802",
"Sample ID":"802_LV",
"Factors":{"Treatment":"Cortisol","Heart Area":"Left_ventricle"},
"Additional sample data":{"Batch":"2"}
},
{
"Subject ID":"1576",
"Sample ID":"1576_S",
"Factors":{"Treatment":"Cortisol","Heart Area":"Septum"},
"Additional sample data":{"Batch":"3"}
},
{
"Subject ID":"1610-16",
"Sample ID":"1610-16_LV",
"Factors":{"Treatment":"Control","Heart Area":"Left_ventricle"},
"Additional sample data":{"Batch":"3"}
},
{
"Subject ID":"1577",
"Sample ID":"1577_RV",
"Factors":{"Treatment":"Control","Heart Area":"Right_ventricle"},
"Additional sample data":{"Batch":"3"}
},
{
"Subject ID":"1576",
"Sample ID":"1576_LV",
"Factors":{"Treatment":"Cortisol","Heart Area":"Left_ventricle"},
"Additional sample data":{"Batch":"3"}
},
{
"Subject ID":"1610-16",
"Sample ID":"1610-16_RV",
"Factors":{"Treatment":"Control","Heart Area":"Right_ventricle"},
"Additional sample data":{"Batch":"3"}
},
{
"Subject ID":"1576",
"Sample ID":"1576_RV",
"Factors":{"Treatment":"Cortisol","Heart Area":"Right_ventricle"},
"Additional sample data":{"Batch":"3"}
},
{
"Subject ID":"1610-16",
"Sample ID":"1610-16_S",
"Factors":{"Treatment":"Control","Heart Area":"Septum"},
"Additional sample data":{"Batch":"3"}
},
{
"Subject ID":"1577",
"Sample ID":"1577_LV",
"Factors":{"Treatment":"Control","Heart Area":"Left_ventricle"},
"Additional sample data":{"Batch":"3"}
},
{
"Subject ID":"1577",
"Sample ID":"1577_S",
"Factors":{"Treatment":"Control","Heart Area":"Septum"},
"Additional sample data":{"Batch":"3"}
},
{
"Subject ID":"706",
"Sample ID":"706_RV",
"Factors":{"Treatment":"Cortisol","Heart Area":"Right_ventricle"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"706",
"Sample ID":"706_LV",
"Factors":{"Treatment":"Cortisol","Heart Area":"Left_ventricle"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"706",
"Sample ID":"706_S",
"Factors":{"Treatment":"Cortisol","Heart Area":"Septum"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"729",
"Sample ID":"729_S",
"Factors":{"Treatment":"Cortisol","Heart Area":"Septum"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"729",
"Sample ID":"729_RV",
"Factors":{"Treatment":"Cortisol","Heart Area":"Right_ventricle"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"729",
"Sample ID":"729_LV",
"Factors":{"Treatment":"Cortisol","Heart Area":"Left_ventricle"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"734",
"Sample ID":"734_RV",
"Factors":{"Treatment":"Control","Heart Area":"Right_ventricle"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"734",
"Sample ID":"734_S",
"Factors":{"Treatment":"Control","Heart Area":"Septum"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"734",
"Sample ID":"734_LV",
"Factors":{"Treatment":"Control","Heart Area":"Left_ventricle"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"770",
"Sample ID":"770_S",
"Factors":{"Treatment":"Control","Heart Area":"Septum"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"770",
"Sample ID":"770_LV",
"Factors":{"Treatment":"Control","Heart Area":"Left_ventricle"},
"Additional sample data":{"Batch":"1"}
},
{
"Subject ID":"770",
"Sample ID":"770_RV",
"Factors":{"Treatment":"Control","Heart Area":"Right_ventricle"},
"Additional sample data":{"Batch":"1"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Immediately following birth, the lambs were euthanized with an overdose of Euthasol (pentobarbital sodium and phenytoin sodium; Virbac AH Inc), and heart tissue was collected from the right ventricle (RV), left ventricle (LV), and intraventricular septum (IVS) and immediately frozen in liquid nitrogen. Tissue samples were stored at -80 °C until data collection.","SAMPLE_TYPE":"Cardiac tissue","COLLECTION_METHOD":"Heart tissue was collected under sterile conditions and immediately frozen in liquid nitrogen","COLLECTION_LOCATION":"University of Florida","STORAGE_CONDITIONS":"-80℃","COLLECTION_VIALS":"Cryovials","STORAGE_VIALS":"Cryovials"},

"TREATMENT":{"TREATMENT_SUMMARY":"The treatment protocol for this study was previous published in Antolic, A., et al. (2018). Chronic maternal hypercortisolemia in late gestation alters fetal cardiac function at birth. Am J Physiol Regul Integr Comp Physiol 314(3): R342-R352.","TREATMENT_COMPOUND":"Hydrocortisone sodium succinate in sodium phosphate (Solu-Cortef; Pfizer, New York, NY, USA)","TREATMENT_DOSE":"1 mg/kg/day"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Heart tissue (20-50 mg) was cut and weighed on dry ice before being placed on a sterile agar plate. Thirty μL of deuterium oxide (D2O) was added to each tissue sample before being placed in a 4 mm HR-MAS rotor (Bruker Biospin, Billerica, MA, USA) and leftover D2O (from original 30 μL) was added to the rotor with a pipette after placement of tissue. The samples were kept on dry ice until data acquisition.","SAMPLEPREP_PROTOCOL_COMMENTS":"Organ: Heart"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"-","INSTRUMENT_NAME":"-","COLUMN_NAME":"-"},

"ANALYSIS":{"PROCESSING_PARAMETERS_FILE":"Hearts_CORT_raw_data_noesy.zip","ANALYSIS_TYPE":"NMR"},

"NM":{"INSTRUMENT_NAME":"Bruker Avance III","INSTRUMENT_TYPE":"FT-NMR","NMR_EXPERIMENT_TYPE":"1D-1H","FIELD_FREQUENCY_LOCK":"H2O+D2O","SPECTROMETER_FREQUENCY":"600 MHz","NMR_PROBE":"4mm HR-MAS","NMR_SOLVENT":"D2O","NMR_TUBE_SIZE":"4mm HRMAS rotor","SHIMMING_METHOD":"Topshim","PULSE_SEQUENCE":"noesypr1d","WATER_SUPPRESSION":"Presaturation","POWER_LEVEL":"18 W","RECEIVER_GAIN":"40.3","OFFSET_FREQUENCY":"2819.74","PRESATURATION_POWER_LEVEL":"3.98E-05","TEMPERATURE":"4C","NUMBER_OF_SCANS":"128","DUMMY_SCANS":"8","ACQUISITION_TIME":"1.3598 sec","RELAXATION_DELAY":"2 sec","SPECTRAL_WIDTH":"10.0155 ppm","NUM_DATA_POINTS_ACQUIRED":"16344","REAL_DATA_POINTS":"32768","LINE_BROADENING":"2"},

"NMR_METABOLITE_DATA":{
"Units":"Area under the curve",

"Data":[{"Metabolite":"2-Hydroxybutyrate","717_LV":"0.221085912","3843_RV":"1.103881091","717_RV":"0.046581911","3843_LV":"0.72055307","3843_S":"1.346920958","717_S":"0.044490718","753_S":"0.785802783","767_S":"0.109778116","753_LV":"0.604392538","767_LV":"0.339052711","802_S":"0.40976999","753_RV":"1.172995857","767_RV":"0.148127672","802_RV":"0.33038002","802_LV":"0.265838161","1576_S":"0.359757794","1610-16_LV":"0.937831157","1577_RV":"0.295442014","1576_LV":"0.355178177","1610-16_RV":"0.355232055","1576_RV":"0.445531324","1610-16_S":"0.282505943","1577_LV":"0.326551082","1577_S":"0.580459408","706_RV":"0.490297978","706_LV":"0.529375483","706_S":"0.361158836","729_S":"0.930576362","729_RV":"0.80630146","729_LV":"0.701216635","734_RV":"0.348864789","734_S":"0.19863292","734_LV":"0.898808133","770_S":"0.309529006","770_LV":"0.455387363","770_RV":"0.298113106"},{"Metabolite":"Lipid_CH3","717_LV":"17.87278281","3843_RV":"16.35063729","717_RV":"18.06339631","3843_LV":"15.83680958","3843_S":"14.03565009","717_S":"18.99068036","753_S":"13.23871007","767_S":"14.89285724","753_LV":"22.94372718","767_LV":"38.40218761","802_S":"15.00193132","753_RV":"10.67100303","767_RV":"19.28845702","802_RV":"14.7794889","802_LV":"14.48404413","1576_S":"16.97683017","1610-16_LV":"10.60990198","1577_RV":"19.37767968","1576_LV":"16.97683017","1610-16_RV":"16.53251711","1576_RV":"15.8917709","1610-16_S":"14.95637499","1577_LV":"32.52622825","1577_S":"23.69297283","706_RV":"44.43436024","706_LV":"33.41284801","706_S":"18.17297605","729_S":"23.920848","729_RV":"14.7400913","729_LV":"16.97956977","734_RV":"14.52001098","734_S":"18.12417163","734_LV":"16.63517629","770_S":"18.13706337","770_LV":"20.53676767","770_RV":"19.21904823"},{"Metabolite":"Isoleucine","717_LV":"0.099603102","3843_RV":"0.661236826","717_RV":"0.112640515","3843_LV":"0.654713472","3843_S":"1.046013302","717_S":"0.115892052","753_S":"0.648068171","767_S":"0.20505029","753_LV":"0.414149923","767_LV":"0.199469411","802_S":"0.295800671","753_RV":"0.747444472","767_RV":"0.10799596","802_RV":"0.371478607","802_LV":"0.279027483","1576_S":"0.358181186","1610-16_LV":"0.479749903","1577_RV":"0.333955744","1576_LV":"0.509484617","1610-16_RV":"0.33773737","1576_RV":"0.44375727","1610-16_S":"0.207280871","1577_LV":"0.350425973","1577_S":"0.225651511","706_RV":"0.496953089","706_LV":"0.292565936","706_S":"0.183603957","729_S":"0.697132172","729_RV":"0.530212054","729_LV":"0.458184764","734_RV":"0.339708152","734_S":"0.275767455","734_LV":"0.58574506","770_S":"0.309288368","770_LV":"0.344119021","770_RV":"0.232791059"},{"Metabolite":"Valine","717_LV":"0.380039462","3843_RV":"0.105487363","717_RV":"0.389832673","3843_LV":"0.139611224","3843_S":"0.111069226","717_S":"0.351105379","753_S":"0.029062997","767_S":"0.116448296","753_LV":"0.057151193","767_LV":"0.058837919","802_S":"0.298152215","753_RV":"0.044644148","767_RV":"0.054673086","802_RV":"0.249450474","802_LV":"0.299308366","1576_S":"0.20672034","1610-16_LV":"0.078275243","1577_RV":"0.112279917","1576_LV":"0.200953357","1610-16_RV":"0.079966145","1576_RV":"0.178575967","1610-16_S":"0.051601544","1577_LV":"0.114108928","1577_S":"0.099124102","706_RV":"0.092343608","706_LV":"0.062377629","706_S":"0.095619299","729_S":"0.08548836","729_RV":"0.086249361","729_LV":"0.061042758","734_RV":"0.10970584","734_S":"0.080174718","734_LV":"0.086853528","770_S":"0.092862229","770_LV":"0.084771023","770_RV":"0.060658693"},{"Metabolite":"12-Propanediol","717_LV":"0.78694033","3843_RV":"6.313194266","717_RV":"0.390742181","3843_LV":"5.20169332","3843_S":"8.868582173","717_S":"0.299760415","753_S":"6.796108697","767_S":"1.306551235","753_LV":"6.187345601","767_LV":"0.618630817","802_S":"2.907000287","753_RV":"7.85320045","767_RV":"0.866511541","802_RV":"2.922038185","802_LV":"3.134561731","1576_S":"3.536048769","1610-16_LV":"3.56114489","1577_RV":"3.219513823","1576_LV":"3.827487595","1610-16_RV":"4.639670932","1576_RV":"3.235300093","1610-16_S":"3.767175949","1577_LV":"3.152928147","1577_S":"2.700388416","706_RV":"2.38067806","706_LV":"2.204062257","706_S":"2.072128142","729_S":"5.121741246","729_RV":"4.897101425","729_LV":"5.103886162","734_RV":"2.504784085","734_S":"9.946923677","734_LV":"4.936769616","770_S":"4.098987982","770_LV":"3.486285949","770_RV":"4.232505307"},{"Metabolite":"Ethanol","717_LV":"2.52973594","3843_RV":"2.163148292","717_RV":"0.255217478","3843_LV":"1.26878427","3843_S":"2.486898732","717_S":"0.375225734","753_S":"2.111720829","767_S":"0.09811571","753_LV":"1.657907995","767_LV":"1.006268581","802_S":"0.594456238","753_RV":"2.422854172","767_RV":"0.508312972","802_RV":"0.581318009","802_LV":"0.554405561","1576_S":"0.83207902","1610-16_LV":"1.043965489","1577_RV":"1.036353279","1576_LV":"0.739636499","1610-16_RV":"0.929383791","1576_RV":"0.750018598","1610-16_S":"1.023340783","1577_LV":"0.631511231","1577_S":"1.352618692","706_RV":"0.630912609","706_LV":"1.38027085","706_S":"0.696907539","729_S":"0.568743737","729_RV":"1.540635784","729_LV":"0.797025783","734_RV":"0.379930504","734_S":"1.245351951","734_LV":"0.464762822","770_S":"0.885281416","770_LV":"0.733392392","770_RV":"0.542693589"},{"Metabolite":"Alanine","717_LV":"3.717411619","3843_RV":"2.434126118","717_RV":"5.381883739","3843_LV":"1.939139678","3843_S":"2.088876284","717_S":"4.727919805","753_S":"2.299983988","767_S":"2.679542669","753_LV":"2.299983988","767_LV":"3.235437482","802_S":"2.299983988","753_RV":"2.940776898","767_RV":"1.860354757","802_RV":"3.293449163","802_LV":"1.895839981","1576_S":"3.463545657","1610-16_LV":"2.809063631","1577_RV":"1.409579878","1576_LV":"3.751733216","1610-16_RV":"3.260842421","1576_RV":"3.966263735","1610-16_S":"3.260842421","1577_LV":"1.533707799","1577_S":"1.402085363","706_RV":"1.582852117","706_LV":"1.492068952","706_S":"2.157583996","729_S":"1.648308406","729_RV":"2.226377271","729_LV":"2.178803812","734_RV":"3.236200947","734_S":"2.492737304","734_LV":"3.597707897","770_S":"2.259404888","770_LV":"2.204558509","770_RV":"2.060640239"},{"Metabolite":"Lipid_Beta_CH2","717_LV":"5.343244334","3843_RV":"5.000381903","717_RV":"6.105193132","3843_LV":"4.479502199","3843_S":"3.08393588","717_S":"8.004108618","753_S":"2.559566095","767_S":"2.342685545","753_LV":"7.708699152","767_LV":"14.39751611","802_S":"3.877809438","753_RV":"2.15508507","767_RV":"5.335093133","802_RV":"2.723566511","802_LV":"3.118367512","1576_S":"5.251906995","1610-16_LV":"1.261056049","1577_RV":"7.199097936","1576_LV":"5.488330407","1610-16_RV":"1.572576917","1576_RV":"3.960557271","1610-16_S":"1.894189933","1577_LV":"9.628931022","1577_S":"8.039566099","706_RV":"15.08770455","706_LV":"10.68085692","706_S":"4.645509602","729_S":"4.786819287","729_RV":"2.413998187","729_LV":"2.627367095","734_RV":"3.194252352","734_S":"2.876862469","734_LV":"3.821380668","770_S":"4.447056178","770_LV":"5.812694674","770_RV":"4.601150564"},{"Metabolite":"Lipid_Alpha_CH2","717_LV":"3.972709784","3843_RV":"3.805272691","717_RV":"5.644009327","3843_LV":"3.915656456","3843_S":"2.740525419","717_S":"6.800339756","753_S":"2.482451812","767_S":"2.003392386","753_LV":"7.813977276","767_LV":"15.32786566","802_S":"3.684313106","753_RV":"1.667225263","767_RV":"5.710847671","802_RV":"2.7831299","802_LV":"3.12108424","1576_S":"4.3140384","1610-16_LV":"0.941654137","1577_RV":"6.678692929","1576_LV":"4.197844433","1610-16_RV":"1.973297141","1576_RV":"3.563376321","1610-16_S":"2.694374212","1577_LV":"10.95395643","1577_S":"8.825675383","706_RV":"17.60073029","706_LV":"12.6139157","706_S":"4.618538571","729_S":"5.666160537","729_RV":"2.550378682","729_LV":"3.383468964","734_RV":"3.136361971","734_S":"2.795717302","734_LV":"3.562074735","770_S":"4.255091185","770_LV":"5.36823606","770_RV":"4.221678224"},{"Metabolite":"Glutamate","717_LV":"1.35697957","3843_RV":"2.407235061","717_RV":"1.452339846","3843_LV":"1.713529937","3843_S":"2.023279386","717_S":"1.22351387","753_S":"2.696662347","767_S":"3.786515274","753_LV":"2.331446737","767_LV":"2.433639179","802_S":"3.327997865","753_RV":"3.139496263","767_RV":"2.337240639","802_RV":"3.822677214","802_LV":"3.081757034","1576_S":"2.07904007","1610-16_LV":"2.852813096","1577_RV":"2.611793982","1576_LV":"2.04889773","1610-16_RV":"4.094749302","1576_RV":"2.313241274","1610-16_S":"3.474917517","1577_LV":"1.832997233","1577_S":"2.313241274","706_RV":"3.202753941","706_LV":"2.592662704","706_S":"3.549606503","729_S":"2.43440298","729_RV":"2.716808665","729_LV":"2.670385813","734_RV":"3.144901219","734_S":"2.43440298","734_LV":"3.175322255","770_S":"3.583368577","770_LV":"2.852472418","770_RV":"3.37613626"},{"Metabolite":"Succinate","717_LV":"0.424955014","3843_RV":"0.218135015","717_RV":"0.317900127","3843_LV":"0.312372336","3843_S":"0.223697354","717_S":"0.389876574","753_S":"0.19510967","767_S":"0.219263091","753_LV":"0.159177797","767_LV":"0.236442713","802_S":"0.433986675","753_RV":"0.107302713","767_RV":"0.312731515","802_RV":"0.350778304","802_LV":"0.528821659","1576_S":"0.464383289","1610-16_LV":"0.110739694","1577_RV":"0.393211775","1576_LV":"0.447126754","1610-16_RV":"0.104896046","1576_RV":"0.704739944","1610-16_S":"0.382884047","1577_LV":"0.198575271","1577_S":"0.272453448","706_RV":"0.248192379","706_LV":"0.258522438","706_S":"0.336383679","729_S":"0.129016658","729_RV":"0.178269276","729_LV":"0.147662588","734_RV":"0.25582764","734_S":"0.183376725","734_LV":"0.226956448","770_S":"0.264246005","770_LV":"0.306049925","770_RV":"0.289558682"},{"Metabolite":"Glutamine","717_LV":"3.038749036","3843_RV":"2.479940249","717_RV":"2.190535698","3843_LV":"2.644442836","3843_S":"2.379038662","717_S":"1.915631376","753_S":"1.55325201","767_S":"2.144017729","753_LV":"1.307280253","767_LV":"1.763178951","802_S":"2.977303251","753_RV":"2.019105178","767_RV":"1.867138946","802_RV":"3.280192102","802_LV":"3.018887249","1576_S":"2.407411248","1610-16_LV":"1.705949616","1577_RV":"2.27621782","1576_LV":"2.374612891","1610-16_RV":"1.413115541","1576_RV":"2.748090954","1610-16_S":"0.952762977","1577_LV":"2.962749734","1577_S":"2.217674517","706_RV":"2.103834335","706_LV":"2.040233335","706_S":"2.350538214","729_S":"1.149479329","729_RV":"1.531525336","729_LV":"1.332522207","734_RV":"1.928531579","734_S":"0.972026538","734_LV":"1.677527632","770_S":"1.866630605","770_LV":"2.209936003","770_RV":"2.402539032"},{"Metabolite":"Glutathione","717_LV":"0.602340189","3843_RV":"0.531671353","717_RV":"0.548546322","3843_LV":"0.517121598","3843_S":"0.566117873","717_S":"0.50569175","753_S":"0.499565332","767_S":"0.773398302","753_LV":"0.422357206","767_LV":"0.593051668","802_S":"0.626052288","753_RV":"0.55593291","767_RV":"0.496520687","802_RV":"0.559245928","802_LV":"0.579253595","1576_S":"0.570424297","1610-16_LV":"0.605164225","1577_RV":"0.506577944","1576_LV":"0.501873875","1610-16_RV":"0.515018713","1576_RV":"0.534356608","1610-16_S":"0.293642959","1577_LV":"0.67549764","1577_S":"0.636556297","706_RV":"0.606146868","706_LV":"0.530042722","706_S":"0.690364735","729_S":"0.406973184","729_RV":"0.503101639","729_LV":"0.396632361","734_RV":"0.617272574","734_S":"0.532004928","734_LV":"0.722829427","770_S":"0.47906462","770_LV":"0.490867287","770_RV":"0.426379398"},{"Metabolite":"Dimethylamine","717_LV":"0.204139858","3843_RV":"0.152964912","717_RV":"0.210979621","3843_LV":"0.138198694","3843_S":"0.123933815","717_S":"0.232156405","753_S":"0.294848662","767_S":"0.203498558","753_LV":"0.276157431","767_LV":"0.134613032","802_S":"0.190708666","753_RV":"0.368670253","767_RV":"0.156232996","802_RV":"0.206229847","802_LV":"0.251367417","1576_S":"0.170276552","1610-16_LV":"0.261586863","1577_RV":"0.259045365","1576_LV":"0.152679337","1610-16_RV":"0.442989885","1576_RV":"0.197295668","1610-16_S":"0.443202482","1577_LV":"0.253933379","1577_S":"0.236355492","706_RV":"0.142919866","706_LV":"0.156416755","706_S":"0.236284006","729_S":"0.193656482","729_RV":"0.259478932","729_LV":"0.305238684","734_RV":"0.324707811","734_S":"0.439330922","734_LV":"0.287157601","770_S":"0.415779854","770_LV":"0.305421321","770_RV":"0.381809334"},{"Metabolite":"Creatine","717_LV":"14.44714428","3843_RV":"13.02619828","717_RV":"12.76372453","3843_LV":"15.70947306","3843_S":"14.25264935","717_S":"14.80214475","753_S":"13.4546082","767_S":"13.75072139","753_LV":"12.47777501","767_LV":"10.04522211","802_S":"12.43608091","753_RV":"13.4426956","767_RV":"13.80262629","802_RV":"13.4546082","802_LV":"16.81991766","1576_S":"13.37496676","1610-16_LV":"14.02026092","1577_RV":"10.53516534","1576_LV":"13.44849733","1610-16_RV":"14.7010526","1576_RV":"14.71373028","1610-16_S":"15.11180959","1577_LV":"14.02026092","1577_S":"15.78499466","706_RV":"10.17731956","706_LV":"13.18953626","706_S":"11.54388251","729_S":"10.70358886","729_RV":"12.49558588","729_LV":"13.1262782","734_RV":"14.38860697","734_S":"15.28649378","734_LV":"13.14044045","770_S":"13.77207691","770_LV":"12.40400332","770_RV":"12.20006688"},{"Metabolite":"Ethanolamine","717_LV":"0.71845758","3843_RV":"0.556258714","717_RV":"0.681620273","3843_LV":"0.593505728","3843_S":"0.603939627","717_S":"0.70008445","753_S":"0.635280451","767_S":"0.766783669","753_LV":"0.573599889","767_LV":"0.484875275","802_S":"0.66405726","753_RV":"0.729221968","767_RV":"0.651955908","802_RV":"0.598864605","802_LV":"0.69860061","1576_S":"0.560519142","1610-16_LV":"0.692062482","1577_RV":"0.595795669","1576_LV":"0.541762355","1610-16_RV":"0.7743416","1576_RV":"0.645748213","1610-16_S":"0.721279313","1577_LV":"0.714322339","1577_S":"0.56392388","706_RV":"0.473452164","706_LV":"0.515715826","706_S":"0.685380483","729_S":"0.614036654","729_RV":"0.592549743","729_LV":"0.628485691","734_RV":"0.52842588","734_S":"0.515169549","734_LV":"0.578983854","770_S":"0.666297192","770_LV":"0.797449292","770_RV":"0.628485691"},{"Metabolite":"Choline","717_LV":"2.013611842","3843_RV":"1.587518889","717_RV":"2.034138058","3843_LV":"1.979430472","3843_S":"1.890019662","717_S":"2.098065048","753_S":"1.83825287","767_S":"2.604106495","753_LV":"1.405228344","767_LV":"2.060485633","802_S":"1.693102402","753_RV":"1.891759771","767_RV":"2.625255011","802_RV":"1.836519385","802_LV":"1.90296964","1576_S":"2.221392354","1610-16_LV":"2.033110346","1577_RV":"1.019136802","1576_LV":"2.474012499","1610-16_RV":"2.379815157","1576_RV":"2.636040942","1610-16_S":"2.707026977","1577_LV":"1.368883872","1577_S":"1.303644325","706_RV":"1.269449502","706_LV":"1.563687603","706_S":"1.450532484","729_S":"2.913721244","729_RV":"2.412046586","729_LV":"2.791868575","734_RV":"1.510110698","734_S":"1.800608853","734_LV":"1.530375989","770_S":"2.861883849","770_LV":"3.390346959","770_RV":"2.962601473"},{"Metabolite":"Glycerophosphocholine","717_LV":"7.907618046","3843_RV":"9.209097778","717_RV":"6.699506496","3843_LV":"9.748558378","3843_S":"10.50188797","717_S":"6.480406045","753_S":"12.46889548","767_S":"9.820724263","753_LV":"9.67026253","767_LV":"9.344299369","802_S":"6.478931162","753_RV":"13.22120415","767_RV":"11.12524761","802_RV":"9.537574508","802_LV":"7.94822464","1576_S":"6.876286868","1610-16_LV":"10.79099502","1577_RV":"11.22792131","1576_LV":"6.225007134","1610-16_RV":"15.48254514","1576_RV":"7.123950532","1610-16_S":"12.45326163","1577_LV":"10.80505453","1577_S":"9.442039175","706_RV":"7.422511382","706_LV":"7.896534454","706_S":"8.415423907","729_S":"12.76560085","729_RV":"13.69750928","729_LV":"17.31874052","734_RV":"10.42563286","734_S":"14.02203686","734_LV":"9.494965788","770_S":"11.4550769","770_LV":"10.41321924","770_RV":"12.7478671"},{"Metabolite":"Scyllo-inositol","717_LV":"0.777718897","3843_RV":"0.729023816","717_RV":"0.623957217","3843_LV":"1.020876657","3843_S":"0.79950939","717_S":"0.76069309","753_S":"0.769767414","767_S":"0.600446239","753_LV":"0.863044668","767_LV":"0.451031608","802_S":"0.966529419","753_RV":"0.774759457","767_RV":"0.550479583","802_RV":"1.013753533","802_LV":"1.242863671","1576_S":"0.901009236","1610-16_LV":"0.871621974","1577_RV":"0.493573776","1576_LV":"1.161076544","1610-16_RV":"0.949807151","1576_RV":"0.884599318","1610-16_S":"0.819092519","1577_LV":"0.731838702","1577_S":"0.441298996","706_RV":"0.668702904","706_LV":"0.736784959","706_S":"0.734857908","729_S":"0.675320522","729_RV":"0.809006996","729_LV":"0.820516357","734_RV":"0.933439393","734_S":"1.101156306","734_LV":"1.040358925","770_S":"0.630214837","770_LV":"0.625958385","770_RV":"0.522437661"},{"Metabolite":"Taurine","717_LV":"7.463291573","3843_RV":"8.225368534","717_RV":"9.09213179","3843_LV":"6.092552605","3843_S":"7.43874875","717_S":"9.261521891","753_S":"9.076364047","767_S":"14.50179046","753_LV":"6.59047941","767_LV":"10.2822373","802_S":"5.602807016","753_RV":"11.17309874","767_RV":"8.3943735","802_RV":"7.076339989","802_LV":"5.241045041","1576_S":"11.72547609","1610-16_LV":"3.26967887","1577_RV":"13.11627343","1576_LV":"8.666849623","1610-16_RV":"5.657464895","1576_RV":"11.90339792","1610-16_S":"7.816333197","1577_LV":"7.625129887","1577_S":"10.27954805","706_RV":"8.800652301","706_LV":"9.158174295","706_S":"13.19720896","729_S":"4.154383573","729_RV":"4.835603088","729_LV":"5.082370016","734_RV":"12.19139946","734_S":"17.75146442","734_LV":"9.512661904","770_S":"11.58898472","770_LV":"8.291054052","770_RV":"10.07991347"},{"Metabolite":"Myoinositol","717_LV":"8.612126542","3843_RV":"7.843566502","717_RV":"5.799768944","3843_LV":"9.892739949","3843_S":"9.389710395","717_S":"7.386903986","753_S":"9.704169461","767_S":"6.729959873","753_LV":"10.440152","767_LV":"4.673496885","802_S":"9.479261598","753_RV":"8.370562096","767_RV":"7.994169598","802_RV":"9.753176622","802_LV":"12.39868818","1576_S":"9.163719011","1610-16_LV":"9.322145079","1577_RV":"4.925194835","1576_LV":"11.24149399","1610-16_RV":"9.289092158","1576_RV":"9.502226508","1610-16_S":"11.4967993","1577_LV":"8.269010643","1577_S":"6.012635922","706_RV":"5.362786019","706_LV":"7.569012204","706_S":"7.362808486","729_S":"8.37145954","729_RV":"9.009462291","729_LV":"9.447309199","734_RV":"8.645533849","734_S":"12.84112672","734_LV":"11.80530823","770_S":"7.139325127","770_LV":"7.12377345","770_RV":"6.493354541"},{"Metabolite":"Betaine","717_LV":"1.546200555","3843_RV":"2.418334719","717_RV":"1.224783263","3843_LV":"2.484849762","3843_S":"2.418334719","717_S":"1.526393084","753_S":"2.766686605","767_S":"3.097526408","753_LV":"2.358585502","767_LV":"2.106852045","802_S":"1.525662568","753_RV":"2.684466745","767_RV":"2.798628963","802_RV":"2.350282796","802_LV":"1.662311284","1576_S":"2.264356917","1610-16_LV":"2.541517331","1577_RV":"1.58479801","1576_LV":"2.050527125","1610-16_RV":"2.931463175","1576_RV":"2.20980245","1610-16_S":"4.043781324","1577_LV":"1.32708745","1577_S":"2.010322854","706_RV":"1.077066241","706_LV":"1.41144056","706_S":"1.709071588","729_S":"2.513393278","729_RV":"3.25457325","729_LV":"3.878811301","734_RV":"1.972450397","734_S":"2.775042177","734_LV":"2.113092087","770_S":"3.519681969","770_LV":"3.169807656","770_RV":"2.998027586"},{"Metabolite":"Lactate","717_LV":"10.56369848","3843_RV":"6.409004805","717_RV":"11.1566203","3843_LV":"4.757958147","3843_S":"5.928387439","717_S":"9.638022749","753_S":"5.162285138","767_S":"7.621608846","753_LV":"5.300684425","767_LV":"6.748890671","802_S":"5.182351819","753_RV":"5.420962892","767_RV":"5.443826746","802_RV":"7.229639688","802_LV":"6.758133506","1576_S":"7.507648425","1610-16_LV":"5.865857573","1577_RV":"3.642865651","1576_LV":"5.968913708","1610-16_RV":"7.517598673","1576_RV":"6.308998956","1610-16_S":"7.266532604","1577_LV":"6.136824136","1577_S":"5.859105619","706_RV":"5.741621146","706_LV":"4.728026606","706_S":"4.959160089","729_S":"5.598977369","729_RV":"5.415554927","729_LV":"5.164929241","734_RV":"5.741621146","734_S":"7.950112177","734_LV":"7.149137605","770_S":"5.166152601","770_LV":"4.353678446","770_RV":"4.404488664"},{"Metabolite":"Lipid_CO2CH","717_LV":"0.678240844","3843_RV":"0.837899274","717_RV":"1.063591357","3843_LV":"0.825207166","3843_S":"0.720779162","717_S":"1.283404788","753_S":"0.7729293","767_S":"0.846254432","753_LV":"1.309410464","767_LV":"2.282748391","802_S":"0.715510225","753_RV":"0.605407142","767_RV":"0.9956483","802_RV":"1.04983659","802_LV":"0.891323021","1576_S":"0.875060647","1610-16_LV":"0.724923851","1577_RV":"1.461192057","1576_LV":"1.212370182","1610-16_RV":"0.758634018","1576_RV":"0.806527644","1610-16_S":"0.57438356","1577_LV":"2.055307776","1577_S":"1.126046721","706_RV":"2.277186234","706_LV":"1.945861505","706_S":"1.115718625","729_S":"0.978032866","729_RV":"0.858330002","729_LV":"1.014017931","734_RV":"0.759048228","734_S":"0.71005303","734_LV":"0.941016627","770_S":"0.932044453","770_LV":"0.877334433","770_RV":"1.193008454"},{"Metabolite":"Lipid_CHCH","717_LV":"4.781864024","3843_RV":"4.86885236","717_RV":"6.592371516","3843_LV":"4.341993311","3843_S":"3.108821835","717_S":"8.082035356","753_S":"2.811762499","767_S":"2.941122202","753_LV":"7.021841279","767_LV":"12.9306587","802_S":"4.542493328","753_RV":"2.120453116","767_RV":"5.924926632","802_RV":"2.953362691","802_LV":"3.599141167","1576_S":"4.50352757","1610-16_LV":"2.035020418","1577_RV":"6.58417462","1576_LV":"4.424555052","1610-16_RV":"2.034112688","1576_RV":"3.654540581","1610-16_S":"2.599887888","1577_LV":"11.51535352","1577_S":"8.537220755","706_RV":"15.83841923","706_LV":"11.68707662","706_S":"5.108366938","729_S":"5.001023514","729_RV":"3.464077452","729_LV":"3.902122597","734_RV":"4.415198605","734_S":"2.826588956","734_LV":"3.618520541","770_S":"4.178696215","770_LV":"5.049309799","770_RV":"4.157428342"},{"Metabolite":"Adenosine-5-monophosphate","717_LV":"0.174941327","3843_RV":"0.35249349","717_RV":"0.145825892","3843_LV":"0.293521254","3843_S":"0.339254825","717_S":"0.099012047","753_S":"0.198493482","767_S":"0.349108034","753_LV":"0.161720618","767_LV":"0.233939347","802_S":"0.456950183","753_RV":"0.306886991","767_RV":"0.229528472","802_RV":"0.234210354","802_LV":"0.233939347","1576_S":"0.150699599","1610-16_LV":"0.464367009","1577_RV":"0.212024871","1576_LV":"0.215935468","1610-16_RV":"0.358119247","1576_RV":"0.192284256","1610-16_S":"0.207472383","1577_LV":"0.196165227","1577_S":"0.191267105","706_RV":"0.290334347","706_LV":"0.245428795","706_S":"0.405900672","729_S":"0.165987176","729_RV":"0.307924922","729_LV":"0.268690333","734_RV":"0.22291825","734_S":"0.161384934","734_LV":"0.264723547","770_S":"0.188372555","770_LV":"0.156830834","770_RV":"0.178224516"},{"Metabolite":"Inosine","717_LV":"0.503213143","3843_RV":"0.689714151","717_RV":"0.226484672","3843_LV":"0.551813626","3843_S":"0.384708224","717_S":"0.359623241","753_S":"0.601147681","767_S":"0.569758719","753_LV":"0.345182433","767_LV":"0.29359354","802_S":"0.411680088","753_RV":"0.372563235","767_RV":"0.344028719","802_RV":"0.525121945","802_LV":"0.685388653","1576_S":"0.342584775","1610-16_LV":"0.828002949","1577_RV":"0.469921497","1576_LV":"0.517304346","1610-16_RV":"0.414857982","1576_RV":"0.495361366","1610-16_S":"0.341036153","1577_LV":"0.606050397","1577_S":"0.46156643","706_RV":"0.475238884","706_LV":"0.462424408","706_S":"0.555434139","729_S":"0.628745068","729_RV":"0.493225521","729_LV":"0.416570522","734_RV":"0.72113949","734_S":"0.26287707","734_LV":"0.843559201","770_S":"0.489185885","770_LV":"0.473473215","770_RV":"0.500475465"}],

"Metabolites":[{"Metabolite":"2-Hydroxybutyrate","KEGG ID":""},{"Metabolite":"Lipid_CH3","KEGG ID":""},{"Metabolite":"Isoleucine","KEGG ID":"C00407"},{"Metabolite":"Valine","KEGG ID":"C00183"},{"Metabolite":"12-Propanediol","KEGG ID":"C00583"},{"Metabolite":"Ethanol","KEGG ID":"C00469"},{"Metabolite":"Alanine","KEGG ID":"C00041"},{"Metabolite":"Lipid_Beta_CH2","KEGG ID":""},{"Metabolite":"Lipid_Alpha_CH2","KEGG ID":""},{"Metabolite":"Glutamate","KEGG ID":"C00025"},{"Metabolite":"Succinate","KEGG ID":"C00042"},{"Metabolite":"Glutamine","KEGG ID":"C00064"},{"Metabolite":"Glutathione","KEGG ID":"C00051"},{"Metabolite":"Dimethylamine","KEGG ID":"C00543"},{"Metabolite":"Creatine","KEGG ID":"C00300"},{"Metabolite":"Ethanolamine","KEGG ID":"C00189"},{"Metabolite":"Choline","KEGG ID":"C00114"},{"Metabolite":"Glycerophosphocholine","KEGG ID":"C00670"},{"Metabolite":"Scyllo-inositol","KEGG ID":"C06153"},{"Metabolite":"Taurine","KEGG ID":"C00245"},{"Metabolite":"Myoinositol","KEGG ID":"C00137"},{"Metabolite":"Betaine","KEGG ID":"C00719"},{"Metabolite":"Lactate","KEGG ID":"C00186"},{"Metabolite":"Lipid_CO2CH","KEGG ID":""},{"Metabolite":"Lipid_CHCH","KEGG ID":""},{"Metabolite":"Adenosine-5-monophosphate","KEGG ID":"C00020"},{"Metabolite":"Inosine","KEGG ID":"C00294"}]
}

}