{ "METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001109","ANALYSIS_ID":"AN001803","VERSION":"1","CREATED_ON":"December 5, 2018, 12:21 pm"}, "PROJECT":{"PROJECT_TITLE":"Chronic Maternal Cortisol Excess During Late Gestation Leads to Metabolic Alterations in the Newborn Heart","PROJECT_SUMMARY":"Our laboratory has previously shown in an ovine model of pregnancy that abnormal elevations in maternal cortisol during late gestation lead to increased fetal cardiac arrhythmias and mortality during peripartum. Furthermore, transcriptomic analysis of the fetal heart suggested alterations in TCA cycle intermediates and lipid metabolites in animals exposed to excess cortisol in utero. Therefore, we utilized a sheep model of pregnancy to determine how chronic increases in maternal cortisol alter maternal and fetal serum prior to birth and neonatal cardiac metabolites and lipids at term. Ewes were either infused with 1 mg/kg/day of cortisol starting at gestational day 115 (n=9), or untreated (n=6). Serum was collected from the mother and fetus (125 d-birth), and hearts were collected following birth. Proton nuclear magnetic resonance (1H-NMR) spectroscopy was conducted to measure metabolic profiles of newborn heart specimens as well as fetal and maternal serum specimens. Mass spectrometry was conducted to measure lipid profiles of newborn heart specimens. We observed alterations in amino acid and TCA cycle metabolism as well as lipid and glycerophospholipid metabolism in newborn hearts after excess maternal cortisol in late gestation. In addition, we observed alterations in amino acid and TCA cycle metabolites in fetal but not in maternal serum during late gestation. These results suggest that fetal exposure to excess maternal cortisol alters placental and fetal metabolism prior to birth and limits normal cardiac metabolic maturation, which may contribute to increased risk of peripartum cardiac arrhythmias observed in these animals, or later life cardiomyopathies.","INSTITUTE":"University of Florida","LAST_NAME":"Keller-Wood","FIRST_NAME":"Maureen","ADDRESS":"1345 SW Archer Rd, PO 100487, Gainesville, FL, 32610","EMAIL":"kellerwd@cop.ufl.edu","PHONE":"na"}, "STUDY":{"STUDY_TITLE":"NMR Metabolomics of Newborn Heart Tissue Exposed to Excess Maternal Cortisol in Late Gestation - Maternal (part -IV)","STUDY_TYPE":"Comparison","STUDY_SUMMARY":"Serum from mothers and fetuses exposed to excess maternal cortisol in late gestation and untreated was compared via NMR metabolomic analysis","INSTITUTE":"University of Florida","DEPARTMENT":"Biochemsitry & Molecular Biology","LAST_NAME":"Walejko","FIRST_NAME":"Jacquelyn","ADDRESS":"R3-226 Academic Research Building, Department of Biochemistry and Molecular Biology, PO Box 100245, Gainesville, FL 32610-0245","EMAIL":"jwalejko@uga.edu","PHONE":"NA","NUM_GROUPS":"2","TOTAL_SUBJECTS":"36"}, "SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Ovis aries","TAXONOMY_ID":"9940","AGE_OR_AGE_RANGE":"Gestational days 125-birth"}, "SUBJECT_SAMPLE_FACTORS":[ { "Subject ID":"729", "Sample ID":"F_729_130", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"1","NMR_ID":"4"} }, { "Subject ID":"770", "Sample ID":"F_770_135", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"1","NMR_ID":"6"} }, { "Subject ID":"759", "Sample ID":"F_759_125", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"1","NMR_ID":"7"} }, { "Subject ID":"759", "Sample ID":"F_759_146", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"146","Batch":"1","NMR_ID":"8"} }, { "Subject ID":"728", "Sample ID":"M_728_140", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"1","NMR_ID":"10"} }, { "Subject ID":"729", "Sample ID":"F_729_125", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"1","NMR_ID":"11"} }, { "Subject ID":"770", "Sample ID":"M_770_130", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"1","NMR_ID":"12"} }, { "Subject ID":"734", "Sample ID":"M_734_140", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"1","NMR_ID":"13"} }, { "Subject ID":"759", "Sample ID":"M_759_135", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"1","NMR_ID":"14"} }, { "Subject ID":"770", "Sample ID":"M_770_140", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"1","NMR_ID":"15"} }, { "Subject ID":"734", "Sample ID":"M_734_125", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"1","NMR_ID":"16"} }, { "Subject ID":"728", "Sample ID":"F_728_146", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"146","Batch":"1","NMR_ID":"18"} }, { "Subject ID":"759", "Sample ID":"M_759_130", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"1","NMR_ID":"19"} }, { "Subject ID":"759", "Sample ID":"M_759_138", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"1","NMR_ID":"20"} }, { "Subject ID":"706", "Sample ID":"M_706_140", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"1","NMR_ID":"21"} }, { "Subject ID":"729", "Sample ID":"F_729_135", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"1","NMR_ID":"22"} }, { "Subject ID":"728", "Sample ID":"M_728_147", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"147","Batch":"1","NMR_ID":"23"} }, { "Subject ID":"770", "Sample ID":"M_770_138", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"1","NMR_ID":"24"} }, { "Subject ID":"759", "Sample ID":"F_759_140", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"1","NMR_ID":"25"} }, { "Subject ID":"759", "Sample ID":"M_759_147", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"147","Batch":"1","NMR_ID":"27"} }, { "Subject ID":"734", "Sample ID":"M_734_135", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"1","NMR_ID":"28"} }, { "Subject ID":"734", "Sample ID":"F_734_135", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"1","NMR_ID":"29"} }, { "Subject ID":"706", "Sample ID":"F_706_142", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"1","NMR_ID":"34"} }, { "Subject ID":"770", "Sample ID":"F_770_130", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"1","NMR_ID":"35"} }, { "Subject ID":"734", "Sample ID":"M_734_144", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"144","Batch":"1","NMR_ID":"37"} }, { "Subject ID":"706", "Sample ID":"F_706_140", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"1","NMR_ID":"38"} }, { "Subject ID":"728", "Sample ID":"F_728_135", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"1","NMR_ID":"40"} }, { "Subject ID":"759", "Sample ID":"F_759_135", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"1","NMR_ID":"41"} }, { "Subject ID":"728", "Sample ID":"F_728_130", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"1","NMR_ID":"42"} }, { "Subject ID":"729", "Sample ID":"M_729_130", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"1","NMR_ID":"43"} }, { "Subject ID":"728", "Sample ID":"M_728_135", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"1","NMR_ID":"45"} }, { "Subject ID":"759", "Sample ID":"M_759_145", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"145","Batch":"1","NMR_ID":"46"} }, { "Subject ID":"728", "Sample ID":"M_728_130", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"1","NMR_ID":"47"} }, { "Subject ID":"770", "Sample ID":"F_770_140", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"1","NMR_ID":"48"} }, { "Subject ID":"728", "Sample ID":"F_728_138", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"1","NMR_ID":"50"} }, { "Subject ID":"728", "Sample ID":"F_728_147", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"147","Batch":"1","NMR_ID":"51"} }, { "Subject ID":"770", "Sample ID":"F_770_125", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"1","NMR_ID":"55"} }, { "Subject ID":"706", "Sample ID":"M_706_142", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"1","NMR_ID":"56"} }, { "Subject ID":"770", "Sample ID":"F_770_138", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"1","NMR_ID":"58"} }, { "Subject ID":"706", "Sample ID":"M_706_130", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"1","NMR_ID":"59"} }, { "Subject ID":"734", "Sample ID":"F_734_125", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"1","NMR_ID":"60"} }, { "Subject ID":"734", "Sample ID":"F_734_140", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"1","NMR_ID":"62"} }, { "Subject ID":"706", "Sample ID":"F_706_138", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"1","NMR_ID":"63"} }, { "Subject ID":"734", "Sample ID":"M_734_142", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"1","NMR_ID":"64"} }, { "Subject ID":"759", "Sample ID":"F_759_145", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"145","Batch":"1","NMR_ID":"65"} }, { "Subject ID":"759", "Sample ID":"F_759_142", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"1","NMR_ID":"66"} }, { "Subject ID":"759", "Sample ID":"F_759_130", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"1","NMR_ID":"67"} }, { "Subject ID":"734", "Sample ID":"F_734_138", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"1","NMR_ID":"68"} }, { "Subject ID":"706", "Sample ID":"M_706_135", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"1","NMR_ID":"69"} }, { "Subject ID":"734", "Sample ID":"M_734_143", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"143","Batch":"1","NMR_ID":"71"} }, { "Subject ID":"728", "Sample ID":"M_728_142", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"1","NMR_ID":"72"} }, { "Subject ID":"728", "Sample ID":"M_728_138", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"1","NMR_ID":"73"} }, { "Subject ID":"728", "Sample ID":"M_728_146", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"146","Batch":"1","NMR_ID":"74"} }, { "Subject ID":"734", "Sample ID":"F_734_143", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"143","Batch":"1","NMR_ID":"75"} }, { "Subject ID":"728", "Sample ID":"F_728_144", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"144","Batch":"1","NMR_ID":"76"} }, { "Subject ID":"706", "Sample ID":"F_706_135", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"1","NMR_ID":"77"} }, { "Subject ID":"734", "Sample ID":"M_734_130", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"1","NMR_ID":"78"} }, { "Subject ID":"734", "Sample ID":"M_734_138", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"1","NMR_ID":"79"} }, { "Subject ID":"706", "Sample ID":"M_706_138", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"1","NMR_ID":"80"} }, { "Subject ID":"728", "Sample ID":"F_728_140", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"1","NMR_ID":"82"} }, { "Subject ID":"770", "Sample ID":"M_770_135", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"1","NMR_ID":"83"} }, { "Subject ID":"759", "Sample ID":"M_759_146", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"146","Batch":"1","NMR_ID":"84"} }, { "Subject ID":"728", "Sample ID":"F_728_142", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"1","NMR_ID":"85"} }, { "Subject ID":"759", "Sample ID":"F_759_138", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"1","NMR_ID":"86"} }, { "Subject ID":"759", "Sample ID":"M_759_142", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"1","NMR_ID":"87"} }, { "Subject ID":"734", "Sample ID":"F_734_142", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"1","NMR_ID":"88"} }, { "Subject ID":"759", "Sample ID":"F_759_147", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"147","Batch":"1","NMR_ID":"89"} }, { "Subject ID":"759", "Sample ID":"M_759_144", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"144","Batch":"1","NMR_ID":"90"} }, { "Subject ID":"734", "Sample ID":"F_734_130", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"1","NMR_ID":"91"} }, { "Subject ID":"759", "Sample ID":"F_759_144", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"144","Batch":"1","NMR_ID":"92"} }, { "Subject ID":"729", "Sample ID":"M_729_125", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"1","NMR_ID":"93"} }, { "Subject ID":"759", "Sample ID":"M_759_125", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"1","NMR_ID":"95"} }, { "Subject ID":"734", "Sample ID":"F_734_144", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"144","Batch":"1","NMR_ID":"96"} }, { "Subject ID":"770", "Sample ID":"M_770_125", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"1","NMR_ID":"98"} }, { "Subject ID":"728", "Sample ID":"M_728_144", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"144","Batch":"1","NMR_ID":"99"} }, { "Subject ID":"759", "Sample ID":"M_759_140", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"1","NMR_ID":"101"} }, { "Subject ID":"729", "Sample ID":"M_729_135", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"1","NMR_ID":"102"} }, { "Subject ID":"753", "Sample ID":"M_753_143", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"143","Batch":"2","NMR_ID":"107"} }, { "Subject ID":"753", "Sample ID":"M_753_140", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"2","NMR_ID":"109"} }, { "Subject ID":"753", "Sample ID":"M_753_135", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"2","NMR_ID":"110"} }, { "Subject ID":"753", "Sample ID":"F_753_143", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"143","Batch":"2","NMR_ID":"111"} }, { "Subject ID":"802", "Sample ID":"M_802_142", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"2","NMR_ID":"112"} }, { "Subject ID":"802", "Sample ID":"F_802_135", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"2","NMR_ID":"113"} }, { "Subject ID":"802", "Sample ID":"F_802_138", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"2","NMR_ID":"115"} }, { "Subject ID":"767", "Sample ID":"F_767_125", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"120","Batch":"2","NMR_ID":"116"} }, { "Subject ID":"753", "Sample ID":"F_753_138", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"2","NMR_ID":"117"} }, { "Subject ID":"767", "Sample ID":"F_767_130", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"2","NMR_ID":"118"} }, { "Subject ID":"767", "Sample ID":"M_767_125", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"2","NMR_ID":"119"} }, { "Subject ID":"767", "Sample ID":"M_767_138", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"2","NMR_ID":"120"} }, { "Subject ID":"802", "Sample ID":"F_802_125", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"2","NMR_ID":"121"} }, { "Subject ID":"753", "Sample ID":"M_753_125", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"2","NMR_ID":"122"} }, { "Subject ID":"802", "Sample ID":"F_802_130", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"2","NMR_ID":"125"} }, { "Subject ID":"802", "Sample ID":"M_802_130", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"2","NMR_ID":"126"} }, { "Subject ID":"802", "Sample ID":"F_802_142", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"2","NMR_ID":"127"} }, { "Subject ID":"802", "Sample ID":"M_802_135", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"2","NMR_ID":"129"} }, { "Subject ID":"802", "Sample ID":"F_802_140", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"2","NMR_ID":"130"} }, { "Subject ID":"753", "Sample ID":"F_753_125", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"2","NMR_ID":"131"} }, { "Subject ID":"753", "Sample ID":"F_753_140", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"2","NMR_ID":"132"} }, { "Subject ID":"767", "Sample ID":"M_767_135", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"2","NMR_ID":"133"} }, { "Subject ID":"802", "Sample ID":"M_802_125", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"2","NMR_ID":"134"} }, { "Subject ID":"767", "Sample ID":"M_767_130", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"2","NMR_ID":"135"} }, { "Subject ID":"802", "Sample ID":"M_802_140", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"2","NMR_ID":"136"} }, { "Subject ID":"767", "Sample ID":"F_767_135", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"2","NMR_ID":"138"} }, { "Subject ID":"802", "Sample ID":"M_802_138", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"2","NMR_ID":"139"} }, { "Subject ID":"802", "Sample ID":"M_802_147", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"147","Batch":"2","NMR_ID":"140"} }, { "Subject ID":"802", "Sample ID":"M_802_144", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"144","Batch":"2","NMR_ID":"142"} }, { "Subject ID":"753", "Sample ID":"M_753_138", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"2","NMR_ID":"143"} }, { "Subject ID":"753", "Sample ID":"F_753_135", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"2","NMR_ID":"144"} }, { "Subject ID":"753", "Sample ID":"M_753_130", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"2","NMR_ID":"150"} }, { "Subject ID":"753", "Sample ID":"F_753_130", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"2","NMR_ID":"151"} }, { "Subject ID":"1618", "Sample ID":"F_1618_147", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"147","Batch":"3","NMR_ID":"154"} }, { "Subject ID":"1618", "Sample ID":"F_1618_144", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"144","Batch":"3","NMR_ID":"155"} }, { "Subject ID":"1576", "Sample ID":"F_1576_125", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"3","NMR_ID":"157"} }, { "Subject ID":"1618", "Sample ID":"M_1618_141", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"141","Batch":"3","NMR_ID":"158"} }, { "Subject ID":"1618", "Sample ID":"M_1618_130", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"3","NMR_ID":"159"} }, { "Subject ID":"1577", "Sample ID":"F_1577_135", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"3","NMR_ID":"161"} }, { "Subject ID":"1616", "Sample ID":"M_1616-10_140", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"3","NMR_ID":"162"} }, { "Subject ID":"1576", "Sample ID":"M_1576_140", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"3","NMR_ID":"164"} }, { "Subject ID":"1616", "Sample ID":"M_1616-10_130", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"3","NMR_ID":"165"} }, { "Subject ID":"1618", "Sample ID":"M_1618_144", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"144","Batch":"3","NMR_ID":"166"} }, { "Subject ID":"1577", "Sample ID":"M_1577_135", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"3","NMR_ID":"167"} }, { "Subject ID":"1618", "Sample ID":"M_1618_146", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"146","Batch":"3","NMR_ID":"168"} }, { "Subject ID":"1577", "Sample ID":"F_1577_120", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"120","Batch":"3","NMR_ID":"169"} }, { "Subject ID":"1576", "Sample ID":"F_1576_138", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"3","NMR_ID":"170"} }, { "Subject ID":"1618", "Sample ID":"M_1618_138", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"3","NMR_ID":"172"} }, { "Subject ID":"1618", "Sample ID":"F_1618_146", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"146","Batch":"3","NMR_ID":"173"} }, { "Subject ID":"1576", "Sample ID":"F_1576_142", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"3","NMR_ID":"176"} }, { "Subject ID":"1618", "Sample ID":"F_1618_138", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"3","NMR_ID":"178"} }, { "Subject ID":"1577", "Sample ID":"M_1577_120", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"120","Batch":"3","NMR_ID":"179"} }, { "Subject ID":"1577", "Sample ID":"F_1577_130", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"3","NMR_ID":"180"} }, { "Subject ID":"1576", "Sample ID":"F_1576_140", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"3","NMR_ID":"181"} }, { "Subject ID":"1576", "Sample ID":"F_1576_120", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"120","Batch":"3","NMR_ID":"182"} }, { "Subject ID":"1576", "Sample ID":"M_1576_138", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"3","NMR_ID":"183"} }, { "Subject ID":"1616-10", "Sample ID":"F_1616-10_130", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"3","NMR_ID":"184"} }, { "Subject ID":"1618", "Sample ID":"M_1618_140", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"3","NMR_ID":"185"} }, { "Subject ID":"1618", "Sample ID":"F_1618_148", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"148","Batch":"3","NMR_ID":"186"} }, { "Subject ID":"1618", "Sample ID":"F_1618_140", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"3","NMR_ID":"188"} }, { "Subject ID":"1618", "Sample ID":"F_1618_143", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"143","Batch":"3","NMR_ID":"189"} }, { "Subject ID":"1577", "Sample ID":"M_1577_140", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"3","NMR_ID":"191"} }, { "Subject ID":"1577", "Sample ID":"M_1577_138", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"3","NMR_ID":"192"} }, { "Subject ID":"1577", "Sample ID":"F_1577_138", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"138","Batch":"3","NMR_ID":"193"} }, { "Subject ID":"1618", "Sample ID":"F_1618_135", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"3","NMR_ID":"194"} }, { "Subject ID":"1616-10", "Sample ID":"F_1616-10_137", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"137","Batch":"3","NMR_ID":"196"} }, { "Subject ID":"1577", "Sample ID":"M_1577_125", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"3","NMR_ID":"197"} }, { "Subject ID":"1616-10", "Sample ID":"F_1616-10_140", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"3","NMR_ID":"198"} }, { "Subject ID":"1577", "Sample ID":"M_1577_130", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"3","NMR_ID":"199"} }, { "Subject ID":"1576", "Sample ID":"M_1576_142", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"3","NMR_ID":"202"} }, { "Subject ID":"1616-10", "Sample ID":"M_1616-10_137", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"137","Batch":"3","NMR_ID":"203"} }, { "Subject ID":"1618", "Sample ID":"M_1618_135", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"3","NMR_ID":"204"} }, { "Subject ID":"1616-10", "Sample ID":"F_1616-10_125", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"3","NMR_ID":"205"} }, { "Subject ID":"1618", "Sample ID":"F_1618_150", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"150","Batch":"3","NMR_ID":"207"} }, { "Subject ID":"1576", "Sample ID":"M_1576_130", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"3","NMR_ID":"208"} }, { "Subject ID":"1618", "Sample ID":"F_1618_149", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"149","Batch":"3","NMR_ID":"209"} }, { "Subject ID":"1618", "Sample ID":"F_1618_145", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"145","Batch":"3","NMR_ID":"211"} }, { "Subject ID":"1618", "Sample ID":"F_1618_125", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"3","NMR_ID":"212"} }, { "Subject ID":"1576", "Sample ID":"M_1576_141", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"141","Batch":"3","NMR_ID":"213"} }, { "Subject ID":"1576", "Sample ID":"F_1576_130", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"3","NMR_ID":"215"} }, { "Subject ID":"1576", "Sample ID":"M_1576_135", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"3","NMR_ID":"216"} }, { "Subject ID":"1618", "Sample ID":"M_1618_149", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"149","Batch":"3","NMR_ID":"218"} }, { "Subject ID":"1616-10", "Sample ID":"M_1616-10_125", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"3","NMR_ID":"219"} }, { "Subject ID":"1577", "Sample ID":"F_1577_125", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"3","NMR_ID":"220"} }, { "Subject ID":"1618", "Sample ID":"F_1618_130", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"130","Batch":"3","NMR_ID":"221"} }, { "Subject ID":"1618", "Sample ID":"M_1618_143", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"143","Batch":"3","NMR_ID":"222"} }, { "Subject ID":"1576", "Sample ID":"M_1576_125", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"3","NMR_ID":"223"} }, { "Subject ID":"1618", "Sample ID":"M_1618_125", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"125","Batch":"3","NMR_ID":"224"} }, { "Subject ID":"1576", "Sample ID":"F_1576_144", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"144","Batch":"3","NMR_ID":"225"} }, { "Subject ID":"1576", "Sample ID":"M_1576_120", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"120","Batch":"3","NMR_ID":"226"} }, { "Subject ID":"1576", "Sample ID":"M_1576_143", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"143","Batch":"3","NMR_ID":"227"} }, { "Subject ID":"1618", "Sample ID":"F_1618_142", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"3","NMR_ID":"228"} }, { "Subject ID":"1576", "Sample ID":"M_1576_144", "Factors":{"Treatment":"Cortisol","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"144","Batch":"3","NMR_ID":"229"} }, { "Subject ID":"1618", "Sample ID":"M_1618_142", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"142","Batch":"3","NMR_ID":"230"} }, { "Subject ID":"1618", "Sample ID":"M_1618_148", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"148","Batch":"3","NMR_ID":"231"} }, { "Subject ID":"1576", "Sample ID":"F_1576_135", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"135","Batch":"3","NMR_ID":"232"} }, { "Subject ID":"1618", "Sample ID":"F_1618_141", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"141","Batch":"3","NMR_ID":"233"} }, { "Subject ID":"1576", "Sample ID":"F_1576_143", "Factors":{"Treatment":"Cortisol","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"143","Batch":"3","NMR_ID":"234"} }, { "Subject ID":"1618", "Sample ID":"M_1618_145", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"145","Batch":"3","NMR_ID":"235"} }, { "Subject ID":"1618", "Sample ID":"M_1618_147", "Factors":{"Treatment":"Control","Source":"Maternal"}, "Additional sample data":{"Gestational Age (days)":"147","Batch":"3","NMR_ID":"237"} }, { "Subject ID":"1577", "Sample ID":"F_1577_140", "Factors":{"Treatment":"Control","Source":"Fetal"}, "Additional sample data":{"Gestational Age (days)":"140","Batch":"3","NMR_ID":"238"} } ], "COLLECTION":{"COLLECTION_SUMMARY":"Blood samples were collected from ewe and fetus on gestational days 125, 130, 135, 138, 140, and every subsequent day until birth (control: 144±1; CORT: 142±2 days gestational age);","SAMPLE_TYPE":"Blood (serum)","COLLECTION_METHOD":"samples for metabolomics analysis were collected in glass tubes on ice with no anticoagulant and spun for 20 min at 4 °C; the resulting serum was stored at -20 °C until metabolomic analysis.","COLLECTION_LOCATION":"University of Florida","STORAGE_CONDITIONS":"-20℃","COLLECTION_VIALS":"Eppendorf tubes","STORAGE_VIALS":"Eppendorf tubes"}, "TREATMENT":{"TREATMENT_SUMMARY":"The treatment protocol for this study was previous published in Antolic, A., et al. (2018). Chronic maternal hypercortisolemia in late gestation alters fetal cardiac function at birth. Am J Physiol Regul Integr Comp Physiol 314(3): R342-R352.","TREATMENT_COMPOUND":"Hydrocortisone sodium succinate in sodium phosphate (Solu-Cortef; Pfizer, New York, NY, USA)","TREATMENT_DOSE":"1 mg/kg/day"}, "SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Saline buffer was created by weighing 9 g of NaCl into a 1 L volumetric flask. Next, 100 mL of D2O was added and filled up to 1 L with water and shaken until dissolved. Samples were thawed on ice and centrifuged at 3,000 g for 20 min at 4 °C. Two hundred mL of serum was mixed with 400 mL of Saline buffer and centrifuged for 10 min at 3000 g at 4 °C. For each sample, 500 mL of the resulting supernatant was transferred into a 5 mm SampleJet NMR tube (Bruker Biospin, Billerica, MA, USA)."}, "CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"-","INSTRUMENT_NAME":"-","COLUMN_NAME":"-"}, "ANALYSIS":{"PROCESSING_PARAMETERS_FILE":"Serum_CORT_raw_data_cpmg.zip","ANALYSIS_TYPE":"NMR"}, "NM":{"INSTRUMENT_NAME":"Bruker Avance III","INSTRUMENT_TYPE":"FT-NMR","NMR_EXPERIMENT_TYPE":"1D-1H","FIELD_FREQUENCY_LOCK":"H2O+D2O","SPECTROMETER_FREQUENCY":"600 MHz","NMR_PROBE":"5mm Cryoprobe","NMR_SOLVENT":"D2O","NMR_TUBE_SIZE":"5mm","SHIMMING_METHOD":"Topshim","PULSE_SEQUENCE":"cpmgpr1d","WATER_SUPPRESSION":"Presaturation","POWER_LEVEL":"7.37 W","RECEIVER_GAIN":"64","OFFSET_FREQUENCY":"2824.2","PRESATURATION_POWER_LEVEL":"6.41E-05","TEMPERATURE":"4C","NUMBER_OF_SCANS":"128","DUMMY_SCANS":"16","ACQUISITION_TIME":"1.8173","RELAXATION_DELAY":"4 sec","SPECTRAL_WIDTH":"15.0182 ppm","NUM_DATA_POINTS_ACQUIRED":"32764","REAL_DATA_POINTS":"65536","LINE_BROADENING":"1"}, 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ID":"C00037"},{"Metabolite":"Creatinine","KEGG ID":"C00791"},{"Metabolite":"Glucose","KEGG ID":"C00031"},{"Metabolite":"Tyrosine","KEGG ID":"C00082"},{"Metabolite":"Anserine","KEGG ID":"C01262"},{"Metabolite":"Histidine","KEGG ID":"C00135"},{"Metabolite":"Phenylalanine","KEGG ID":"C00079"},{"Metabolite":"1-Methylhistidine","KEGG ID":"C01152"},{"Metabolite":"Formate","KEGG ID":"C00058"}] } }