{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001140","ANALYSIS_ID":"AN001871","VERSION":"1","CREATED_ON":"February 21, 2019, 4:41 pm"},

"PROJECT":{"PROJECT_TITLE":"Changes in the Canine Plasma Lipidome after Short- and Long-Term Excess Glucocorticoid Exposure","PROJECT_SUMMARY":"Glucocorticoids (GCs) are widely used in veterinary and human medicine. Chromic endogenous or iatrogenic GC overexposure impairs metabolic function and can result in diverse side-effects, including Cushing’s syndrome. This study examines the effects of experimentally induced short-term and long-term GC excess (induced by prednisolone and tetracosactide, respectively) on the plasma lipidome of Beale dogs. Both, long- and short-term GC resulted in significant changes of the plasma lipidome.","INSTITUTE":"National University of Singapore and University of Zurich","DEPARTMENT":"Multiple","LABORATORY":"Singapore Lipidomics Incubator (SLING)","LAST_NAME":"Burla","FIRST_NAME":"Bo","ADDRESS":"28 Medical Drive, Singapore 117456, Singapore","EMAIL":"bo.burla@nus.edu.sg","PHONE":"+6565166683"},

"STUDY":{"STUDY_TITLE":"Changes in the Canine Plasma Lipidome after Short- and Long-Term Excess Glucocorticoid Exposure","STUDY_SUMMARY":"Glucocorticoids (GCs) are widely used in veterinary and human medicine. Chromic endogenous or iatrogenic GC overexposure impairs metabolic function and can result in diverse side-effects, including Cushing’s syndrome. This study examines the effects of experimentally induced short-term and long-term GC excess (induced by prednisolone and tetracosactide, respectively) on the plasma lipidome of Beale dogs. Both, long- and short-term GC resulted in significant changes of the plasma lipidome.","INSTITUTE":"Life Sciences Institute, National University of Singapore","LABORATORY":"Singapore Lipidomics Incubator (SLING)","LAST_NAME":"Burla","FIRST_NAME":"Bo","ADDRESS":"28 Medical Drive, Singapore 117456, Singapore","EMAIL":"bo.burla@nus.edu.sg","PHONE":"+6565166683","NUM_GROUPS":"2","TOTAL_SUBJECTS":"14","NUM_MALES":"9","NUM_FEMALES":"5"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Canis lupus familiaris","TAXONOMY_ID":"9615","GENOTYPE_STRAIN":"Beagle","AGE_OR_AGE_RANGE":"8 to 83 months","WEIGHT_OR_WEIGHT_RANGE":"12.2 to 18.9 kg","GENDER":"Male and female","ANIMAL_ANIMAL_SUPPLIER":"In-house breeding","ANIMAL_FEED":"Standard pellet/kibble maintenance diet"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"P1",
"Sample ID":"Prednisolone-d0-P1",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"0d","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"F","Age_months":"83","Weight_kg":"14.7"}
},
{
"Subject ID":"P1",
"Sample ID":"Prednisolone-d4-P1",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"4d","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"F","Age_months":"89","Weight_kg":"12.6"}
},
{
"Subject ID":"P2",
"Sample ID":"Prednisolone-d0-P2",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"0d","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"F","Age_months":"72","Weight_kg":"14"}
},
{
"Subject ID":"P2",
"Sample ID":"Prednisolone-d4-P2",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"4d","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"F","Age_months":"78","Weight_kg":"11.8"}
},
{
"Subject ID":"P3",
"Sample ID":"Prednisolone-d0-P3",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"0d","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"F","Age_months":"71","Weight_kg":"15.4"}
},
{
"Subject ID":"P3",
"Sample ID":"Prednisolone-d4-P3",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"4d","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"F","Age_months":"77","Weight_kg":"12.2"}
},
{
"Subject ID":"P4",
"Sample ID":"Prednisolone-d0-P4",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"0d","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"M","Age_months":"23","Weight_kg":"16.9"}
},
{
"Subject ID":"P4",
"Sample ID":"Prednisolone-d4-P4",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"4d","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"M","Age_months":"29","Weight_kg":"14.1"}
},
{
"Subject ID":"P5",
"Sample ID":"Prednisolone-d0-P5",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"0d","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"M","Age_months":"23","Weight_kg":"19.8"}
},
{
"Subject ID":"P5",
"Sample ID":"Prednisolone-d4-P5",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"4d","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"M","Age_months":"29","Weight_kg":"16.5"}
},
{
"Subject ID":"P6",
"Sample ID":"Prednisolone-d0-P6",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"0d","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"M","Age_months":"88","Weight_kg":"16.3"}
},
{
"Subject ID":"P6",
"Sample ID":"Prednisolone-d4-P6",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"4d","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"M","Age_months":"94","Weight_kg":"11.9"}
},
{
"Subject ID":"P7",
"Sample ID":"Prednisolone-d0-P7",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"0d","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"M","Age_months":"58","Weight_kg":"12"}
},
{
"Subject ID":"P7",
"Sample ID":"Prednisolone-d4-P7",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"4d","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"M","Age_months":"58","Weight_kg":"13"}
},
{
"Subject ID":"P8",
"Sample ID":"Prednisolone-d0-P8",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"0d","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"M","Age_months":"43","Weight_kg":"13"}
},
{
"Subject ID":"P8",
"Sample ID":"Prednisolone-d4-P8",
"Factors":{"TreatmentGroup":"Prednisolone","TreatmentDuration":"4d","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"M","Age_months":"43","Weight_kg":"14"}
},
{
"Subject ID":"T1",
"Sample ID":"Tetracosactide-w00-T1",
"Factors":{"TreatmentGroup":"Tetracosactide","TreatmentDuration":"00w","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"M","Age_months":"56","Weight_kg":"14"}
},
{
"Subject ID":"T1",
"Sample ID":"Tetracosactide-w25-T1",
"Factors":{"TreatmentGroup":"Tetracosactide","TreatmentDuration":"25w","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"M","Age_months":"56","Weight_kg":"15"}
},
{
"Subject ID":"T2",
"Sample ID":"Tetracosactide-w00-T2",
"Factors":{"TreatmentGroup":"Tetracosactide","TreatmentDuration":"00w","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"F","Age_months":"43","Weight_kg":"15"}
},
{
"Subject ID":"T2",
"Sample ID":"Tetracosactide-w25-T2",
"Factors":{"TreatmentGroup":"Tetracosactide","TreatmentDuration":"25w","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"F","Age_months":"43","Weight_kg":"16"}
},
{
"Subject ID":"T3",
"Sample ID":"Tetracosactide-w00-T3",
"Factors":{"TreatmentGroup":"Tetracosactide","TreatmentDuration":"00w","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"F","Age_months":"8","Weight_kg":"16"}
},
{
"Subject ID":"T3",
"Sample ID":"Tetracosactide-w25-T3",
"Factors":{"TreatmentGroup":"Tetracosactide","TreatmentDuration":"25w","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"F","Age_months":"8","Weight_kg":"17"}
},
{
"Subject ID":"T4",
"Sample ID":"Tetracosactide-w00-T4",
"Factors":{"TreatmentGroup":"Tetracosactide","TreatmentDuration":"00w","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"M","Age_months":"7","Weight_kg":"17"}
},
{
"Subject ID":"T4",
"Sample ID":"Tetracosactide-w25-T4",
"Factors":{"TreatmentGroup":"Tetracosactide","TreatmentDuration":"25w","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"M","Age_months":"7","Weight_kg":"18"}
},
{
"Subject ID":"T5",
"Sample ID":"Tetracosactide-w00-T5",
"Factors":{"TreatmentGroup":"Tetracosactide","TreatmentDuration":"00w","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"M","Age_months":"7","Weight_kg":"18"}
},
{
"Subject ID":"T5",
"Sample ID":"Tetracosactide-w25-T5",
"Factors":{"TreatmentGroup":"Tetracosactide","TreatmentDuration":"25w","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"M","Age_months":"7","Weight_kg":"19"}
},
{
"Subject ID":"T6",
"Sample ID":"Tetracosactide-w00-T6",
"Factors":{"TreatmentGroup":"Tetracosactide","TreatmentDuration":"00w","SamplingTimePoint":"before"},
"Additional sample data":{"Sex":"M","Age_months":"8","Weight_kg":"19"}
},
{
"Subject ID":"T6",
"Sample ID":"Tetracosactide-w25-T6",
"Factors":{"TreatmentGroup":"Tetracosactide","TreatmentDuration":"25w","SamplingTimePoint":"after"},
"Additional sample data":{"Sex":"M","Age_months":"8","Weight_kg":"20"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Blood was collected from the jugular vein after overnight fasting right before start and at the end of the treatments (12 h after the last prednisolone administration and 25 weeks after start of tetracosactide infusion, respectively). Plasma was prepared lithium heparin anticoagulated blood (Vacuette Greiner Bio-One, Germany) that centrifuged immediately after collection (1,862 g, 10 min, 4°C). Plasma samples were stored at −80°C until lipidomic analysis.","COLLECTION_PROTOCOL_COMMENTS":"Blood collected after overnight fasting","SAMPLE_TYPE":"Blood (plasma)","COLLECTION_METHOD":"Venepuncture","COLLECTION_LOCATION":"Jugular vein","COLLECTION_FREQUENCY":"Before and after treatment","STORAGE_CONDITIONS":"-80℃","COLLECTION_VIALS":"VACUETTE® lithium heparin tubes (Greiner Bio-One, Germany)","COLLECTION_TUBE_TEMP":"Room temperature","ADDITIVES":"Lithium heparin"},

"TREATMENT":{"TREATMENT_SUMMARY":"In the short-term prednisolone group, dogs were treated with 50 mg prednisolone (Streuli Pharma AG, Switzerland) orally twice daily for 3 consecutive days. For the long-term tetracosactide treatment, ALZET osmotic pumps (Durect Corporation, USA) subcutaneously delivering tetracosactide (synthetic ACTH; Bachem AG, Switzerland) were implanted into the dorsolateral neck. New pumps were implanted every 4 weeks. Total infusion time was 25 weeks, with a starting dose of 1.3–1.95 µg/kg/d tetracosactide, which was gradually increased to a final dose of 6–10 µg/kg/d."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Plasma lipids were extracted using a single-phase butanol/methanol extraction method (Alshehry et al, Metabolites 2015 with modifications). After thawing on ice, a 10 µL aliquot of each plasma sample was transferred into a 2 mL polypropylene tube (Eppendorf, Germany). Subsequently, 1 µL BHT (2,6-di-tert-butyl-4-methylphenol, 10 mmol/L in ethanol) and 90 µL of 1-butanol:methanol (1:1, v/v) containing internal standards was added to each sample. Following internal standards were added at 50 ng/mL final concentration in the extraction solvent: ceramide d18:1/17:0 (Avanti 860517P), Glucosylceramide (Matreya 1533), Lactosylceramide d18:1/16:0 D3 (Matreya 1534), LPC 20:0 (Avanti 855777P), LPE 14:0 (Avanti 856735P), PI 12:0/13:0 (Avanti LM-1500), PE 14:0/14:0 (Avanti 850745P), PS 14:0/14:0 (Avanti 840033P), SM d18:1/12:0 (Avanti 860583P), and at 100 ng/mL: DG 12:0_12:0 (Avanti 800812P), PC 14:0/14:0 (Avanti 850345P), TAG 16:0_16:0_16:0 d5 (CDN Isotopes D5815). Samples were then vortexed (30 sec) and sonicated in an ultrasound water bath for 30 min (20°C). After centrifugation (14,000 g, 10 min, 4°C), 90 µL of supernatant were transferred into 1.5 mL polypropylene tubes (Sarstedt, Germany) and dried under a nitrogen stream at 37°C. Dried extracts were stored at −80°C until LC-MS analysis. Dried samples were reconstituted with 90 µL 1-butanol:methanol (1:1, v/v) and sonication in an ultrasound water for 10 min. After centrifugation for 10 min at 20,800 g (4°C), supernatants (80 µL) were transferred into autosampler vials with glass inserts (Agilent Technologies, USA). For the analysis of sphingosine-1-phosphate (S1P), lipid extracts were derivatized according to the method described by Narayanaswamy et al. (Anal. Chem., 2014). To 50 µL lipid extract (see above), 50 µL 13C2D2–S1P d18:1 internal standard solution (Toronto Research Chemicals, Canada; 20 ng/mL in 1-butanol:methanol 1:1 [v/v]) was added. Derivatization was performed by adding 20 µL TMS-diazomethane (2 mol/L in hexanes; Acros Organics, Thermo Fisher Scientific, USA) and subsequent incubation for 20 min at 25°C and 700 rpm (Thermomixer, Eppendorf, Germany). To stop the reaction and inactivate TMS, 1 µL acetic acid 100% (glacial) was added. After centrifugation for 10 min at 20,800 g (7°C), supernatants were transferred into autosampler vials for LC-MS analysis. Process Quality Control (PQC) samples were generated by pooling equal volumes of plasma samples within an experimental group. For Blank samples, plasma was omitted. PQC and Blank were processed together with the study plasma samples with the same procedures.","EXTRACTION_METHOD":"Liquid–liquid extraction using butanol:methanol","EXTRACT_STORAGE":"-80℃"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Agilent 1290 Infinity","COLUMN_NAME":"Agilent Zorbax RRHD Eclipse Plus C18 (50 x 2.1 mm, 1.8 µm, 95 Ã…)","FLOW_GRADIENT":"20% B: 2 min, 20% - 60% B: 2 - 7 min, 60% - 100% B: 7 - 9 min, 20% B: 9 - 10.8 min","FLOW_RATE":"0.4 mL/min","COLUMN_TEMPERATURE":"40","SOLVENT_A":"Water:acetonitrile 60:40 (v:v) + 10 mmol/L ammonium formate","SOLVENT_B":"2-Propanol:acetonitrile 90:10 (v:v) + 10 mmol/L ammonium formate","SAMPLE_INJECTION":"1 µL"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","LABORATORY_NAME":"Singapore Lipidomics Incubator","SOFTWARE_VERSION":". MassHunter Data Acquisition B.06","DATA_FORMAT":".d"},

"MS":{"INSTRUMENT_NAME":"Agilent 6495 QQQ","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"Sphingolipids were measured with an Agilent 6495A triple quadrupole mass spectrometer in dynamic MRM mode. The ESI source settings were: polarity: positive, dry gas temperature 200°C, dry gas flow 12 L/min, nebulizer pressure: 25 psi, sheath gas temperature: 250°C, sheath gas flow: 12 L/min, capillary voltage: 3500 V, noozle: 500, iFunnel high pressure RF: 80, iFunnel high pressure RF: 40. MRM transitions with collision energies are detailed in the attached protocol. Data were processed with Agilent MassHunter QQQ Quantitative Analysis (version B.08). Transitions of precursor ions with water loss were used as qualifiers. Normalised peak areas were calculated by dividing the peak areas of the analyte with the corresponding class-specific internal standard. Relative abundance was obtained by multiplying the normalised peak areas with the molar concentration of the corresponding internal standard. Lipid species with a median peak area in the PQC samples below 250 or less than 5 times of the highest signal in Blank samples were excluded. Additionally, the coefficient of variation (CV) of the normalised peak area was calculated for each lipid species in the PQC samples of each experimental group. Species with a CV higher than 25% in any of the two groups were excluded from subsequent evaluation.","CAPILLARY_VOLTAGE":"3500 V","COLLISION_GAS":"Nitrogen","DRY_GAS_FLOW":"12 L/min","DRY_GAS_TEMP":"200°C","FRAGMENT_VOLTAGE":"135 V","NEBULIZER":"25 psi"},

"MS_METABOLITE_DATA":{
"Units":"µmol/L",

"Data":[{"Metabolite":"Cer(d16:1/24:0)","Tetracosactide-w00-T1":"0.007549046","Tetracosactide-w25-T1":"0.023286301","Tetracosactide-w00-T2":"0.00727265","Tetracosactide-w25-T2":"0.013767939","Tetracosactide-w00-T3":"0.007497222","Tetracosactide-w25-T3":"0.022647137","Tetracosactide-w00-T4":"0.016497343","Tetracosactide-w25-T4":"0.008861923","Tetracosactide-w00-T5":"0.01637642","Tetracosactide-w25-T5":"0.012385963","Tetracosactide-w00-T6":"0.010865789","Tetracosactide-w25-T6":"0.0102439","Prednisolone-d0-P1":"0.032200049","Prednisolone-d4-P1":"0.017827495","Prednisolone-d0-P2":"0.026326649","Prednisolone-d4-P2":"0.017050133","Prednisolone-d0-P3":"0.028192317","Prednisolone-d4-P3":"0.017499275","Prednisolone-d0-P4":"0.016514617","Prednisolone-d4-P4":"0.01692921","Prednisolone-d0-P5":"0.0116777","Prednisolone-d4-P5":"0.032338246","Prednisolone-d0-P6":"0.029004228","Prednisolone-d4-P6":"0.020556898","Prednisolone-d0-P7":"0.034566683","Prednisolone-d4-P7":"0.030420754","Prednisolone-d0-P8":"0.023994564","Prednisolone-d4-P8":"0.023217203"},{"Metabolite":"Cer(d18:1/16:0)","Tetracosactide-w00-T1":"0.1781713","Tetracosactide-w25-T1":"0.365757313","Tetracosactide-w00-T2":"0.266755983","Tetracosactide-w25-T2":"0.345459536","Tetracosactide-w00-T3":"0.338566929","Tetracosactide-w25-T3":"0.625119723","Tetracosactide-w00-T4":"0.513283287","Tetracosactide-w25-T4":"0.217834021","Tetracosactide-w00-T5":"0.293894543","Tetracosactide-w25-T5":"0.277224454","Tetracosactide-w00-T6":"0.181850812","Tetracosactide-w25-T6":"0.818544586","Prednisolone-d0-P1":"0.532941901","Prednisolone-d4-P1":"0.697794404","Prednisolone-d0-P2":"0.4818606","Prednisolone-d4-P2":"0.485073695","Prednisolone-d0-P3":"0.341624551","Prednisolone-d4-P3":"0.557299234","Prednisolone-d0-P4":"0.392204885","Prednisolone-d4-P4":"0.452130834","Prednisolone-d0-P5":"0.218317712","Prednisolone-d4-P5":"0.654348522","Prednisolone-d0-P6":"0.482758885","Prednisolone-d4-P6":"0.253730856","Prednisolone-d0-P7":"0.385018608","Prednisolone-d4-P7":"0.68019148","Prednisolone-d0-P8":"0.359417497","Prednisolone-d4-P8":"0.546174324"},{"Metabolite":"Cer(d18:1/18:0)","Tetracosactide-w00-T1":"0.25290167","Tetracosactide-w25-T1":"1.365202602","Tetracosactide-w00-T2":"0.230150885","Tetracosactide-w25-T2":"0.835940213","Tetracosactide-w00-T3":"0.501311917","Tetracosactide-w25-T3":"1.34404109","Tetracosactide-w00-T4":"0.306626","Tetracosactide-w25-T4":"0.393275917","Tetracosactide-w00-T5":"0.275894302","Tetracosactide-w25-T5":"0.633964371","Tetracosactide-w00-T6":"0.281284009","Tetracosactide-w25-T6":"2.288172776","Prednisolone-d0-P1":"0.40419353","Prednisolone-d4-P1":"0.638473069","Prednisolone-d0-P2":"0.374947456","Prednisolone-d4-P2":"0.448606795","Prednisolone-d0-P3":"0.377590486","Prednisolone-d4-P3":"0.840258889","Prednisolone-d0-P4":"0.259172388","Prednisolone-d4-P4":"0.283702468","Prednisolone-d0-P5":"0.29119969","Prednisolone-d4-P5":"0.853888631","Prednisolone-d0-P6":"0.641306121","Prednisolone-d4-P6":"0.234124067","Prednisolone-d0-P7":"0.396730858","Prednisolone-d4-P7":"0.90158409","Prednisolone-d0-P8":"0.527293073","Prednisolone-d4-P8":"0.497770603"},{"Metabolite":"Cer(d18:1/20:0)","Tetracosactide-w00-T1":"0.104494686","Tetracosactide-w25-T1":"0.319426556","Tetracosactide-w00-T2":"0.098534913","Tetracosactide-w25-T2":"0.279971132","Tetracosactide-w00-T3":"0.223206454","Tetracosactide-w25-T3":"0.554880775","Tetracosactide-w00-T4":"0.085734357","Tetracosactide-w25-T4":"0.075542282","Tetracosactide-w00-T5":"0.132427883","Tetracosactide-w25-T5":"0.152794759","Tetracosactide-w00-T6":"0.084317831","Tetracosactide-w25-T6":"0.716174689","Prednisolone-d0-P1":"0.363425228","Prednisolone-d4-P1":"0.245939964","Prednisolone-d0-P2":"0.437360962","Prednisolone-d4-P2":"0.155437789","Prednisolone-d0-P3":"0.290249581","Prednisolone-d4-P3":"0.273562217","Prednisolone-d0-P4":"0.175856489","Prednisolone-d4-P4":"0.206225419","Prednisolone-d0-P5":"0.130631314","Prednisolone-d4-P5":"0.425942383","Prednisolone-d0-P6":"0.416717691","Prednisolone-d4-P6":"0.092229646","Prednisolone-d0-P7":"0.270072726","Prednisolone-d4-P7":"0.337720468","Prednisolone-d0-P8":"0.341451804","Prednisolone-d4-P8":"0.24210498"},{"Metabolite":"Cer(d18:1/22:0)","Tetracosactide-w00-T1":"0.536966907","Tetracosactide-w25-T1":"1.419583371","Tetracosactide-w00-T2":"0.548903728","Tetracosactide-w25-T2":"1.182315308","Tetracosactide-w00-T3":"1.259533236","Tetracosactide-w25-T3":"2.1874267","Tetracosactide-w00-T4":"0.713410736","Tetracosactide-w25-T4":"0.294153664","Tetracosactide-w00-T5":"0.680398776","Tetracosactide-w25-T5":"0.816108853","Tetracosactide-w00-T6":"0.63840397","Tetracosactide-w25-T6":"2.348686065","Prednisolone-d0-P1":"1.828682917","Prednisolone-d4-P1":"1.787327275","Prednisolone-d0-P2":"2.291368596","Prednisolone-d4-P2":"0.742570437","Prednisolone-d0-P3":"1.567472114","Prednisolone-d4-P3":"1.611695357","Prednisolone-d0-P4":"1.930189079","Prednisolone-d4-P4":"1.460904464","Prednisolone-d0-P5":"0.95765778","Prednisolone-d4-P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}

}