{ "METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001159","ANALYSIS_ID":"AN001917","VERSION":"1","CREATED_ON":"March 27, 2019, 12:34 pm"}, "PROJECT":{"PROJECT_TITLE":"NHP radiation metabolomics","PROJECT_SUMMARY":"Here, we use global metabolomics to differentiate temporal effects (1 – 60 d) found in nonhuman primate (NHP) urine small molecule signatures after a 4 Gy total body irradiation.","INSTITUTE":"Georgetown University","LAST_NAME":"Pannkuk","FIRST_NAME":"Evan","ADDRESS":"3970 Reservoir Rd, NW New Research Build","EMAIL":"elp44@georgetown.edu","PHONE":"2026875650"}, "STUDY":{"STUDY_TITLE":"Targeted NHP urine metabolomics (part-II)","STUDY_SUMMARY":"Here, we use global metabolomics to differentiate temporal effects (1 – 60 d) found in nonhuman primate (NHP) urine small molecule signatures after a 4 Gy total body irradiation.","INSTITUTE":"Georgetown University","LAST_NAME":"Pannkuk","FIRST_NAME":"Evan","ADDRESS":"3970 Reservoir Rd, NW New Research Build","EMAIL":"elp44@georgetown.edu","PHONE":"2026875650"}, "SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Macaca mulatta","TAXONOMY_ID":"9544"}, "SUBJECT_SAMPLE_FACTORS":[ { "Subject ID":"-", "Sample ID":"NHP1", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP2", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP3", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP4", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP5", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP6", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP7", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP8", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP9", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP10", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP11", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP12", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP13", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP14", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP15", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP16", "Factors":{"Treat":"control_validation"} }, { "Subject ID":"-", "Sample ID":"NHP17", "Factors":{"Treat":"exp_validation"} }, { "Subject ID":"-", "Sample ID":"NHP18", "Factors":{"Treat":"exp_validation"} }, { "Subject ID":"-", "Sample ID":"NHP19", "Factors":{"Treat":"exp_validation"} }, { "Subject ID":"-", "Sample ID":"NHP20", "Factors":{"Treat":"exp_validation"} }, { "Subject ID":"-", "Sample ID":"NHP21", "Factors":{"Treat":"exp_validation"} }, { "Subject ID":"-", "Sample ID":"NHP22", "Factors":{"Treat":"exp_validation"} }, { "Subject ID":"-", "Sample ID":"NHP23", "Factors":{"Treat":"exp_validation"} }, { "Subject ID":"-", "Sample ID":"NHP24", "Factors":{"Treat":"exp_validation"} }, { "Subject ID":"-", "Sample ID":"NHP25", "Factors":{"Treat":"control_training"} }, { "Subject ID":"-", "Sample ID":"NHP26", "Factors":{"Treat":"control_training"} }, { "Subject ID":"-", "Sample ID":"NHP27", "Factors":{"Treat":"control_training"} }, { "Subject ID":"-", "Sample ID":"NHP28", "Factors":{"Treat":"control_training"} }, { "Subject ID":"-", "Sample ID":"NHP29", "Factors":{"Treat":"control_training"} }, { "Subject ID":"-", "Sample ID":"NHP30", "Factors":{"Treat":"control_training"} }, { "Subject ID":"-", "Sample ID":"NHP31", "Factors":{"Treat":"control_training"} }, { "Subject ID":"-", "Sample ID":"NHP32", "Factors":{"Treat":"control_training"} }, { "Subject ID":"-", "Sample ID":"NHP33", "Factors":{"Treat":"control_training"} }, { "Subject ID":"-", "Sample ID":"NHP34", "Factors":{"Treat":"control_training"} }, { "Subject ID":"-", "Sample ID":"NHP35", "Factors":{"Treat":"control_training"} }, { "Subject ID":"-", "Sample ID":"NHP36", "Factors":{"Treat":"control_training"} }, { "Subject ID":"-", "Sample ID":"NHP37", "Factors":{"Treat":"exp_training"} }, { "Subject ID":"-", "Sample ID":"NHP38", "Factors":{"Treat":"exp_training"} }, { "Subject ID":"-", "Sample ID":"NHP39", "Factors":{"Treat":"exp_training"} }, { "Subject ID":"-", "Sample ID":"NHP40", "Factors":{"Treat":"exp_training"} }, { "Subject ID":"-", "Sample ID":"NHP41", "Factors":{"Treat":"exp_training"} }, { "Subject ID":"-", "Sample ID":"NHP42", "Factors":{"Treat":"exp_training"} }, { "Subject ID":"-", "Sample ID":"NHP43", "Factors":{"Treat":"exp_training"} }, { "Subject ID":"-", "Sample ID":"NHP44", "Factors":{"Treat":"exp_training"} }, { "Subject ID":"-", "Sample ID":"NHP45", "Factors":{"Treat":"exp_training"} }, { "Subject ID":"-", "Sample ID":"NHP46", "Factors":{"Treat":"exp_training"} }, { "Subject ID":"-", "Sample ID":"NHP47", "Factors":{"Treat":"exp_training"} }, { "Subject ID":"-", "Sample ID":"NHP48", "Factors":{"Treat":"exp_training"} } ], "COLLECTION":{"COLLECTION_SUMMARY":"Urine (10 μl) was diluted with 200 μl cold methanol:acetonitrile:water (80:15:5) spiked with internal standards, vortexed, placed on ice for 10 min, and centrifuged for 10 min (10,000 x g, 4°C)","SAMPLE_TYPE":"Urine"}, "TREATMENT":{"TREATMENT_SUMMARY":"4 Gy at 0.6 Gy/min with a 60Co γ source"}, "SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Urine (10 μl) was diluted with 200 μl cold methanol:acetonitrile:water (80:15:5) spiked with internal standards, vortexed, placed on ice for 10 min, and centrifuged for 10 min (10,000 x g, 4°C)"}, "CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Waters ACQUITY UPLC","COLUMN_NAME":"Acquity BEH amide 1.7 µm 2.1 x 100 mm"}, "ANALYSIS":{"ANALYSIS_TYPE":"MS"}, "MS":{"INSTRUMENT_NAME":"Waters Xevo-TQ-S","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","ION_MODE":"UNSPECIFIED","MS_COMMENTS":"None"}, "MS_METABOLITE_DATA":{ "Units":"ng/ml", "Data":[{"Metabolite":"carnitine","NHP1":"11.6","NHP2":"12.8","NHP3":"11.3","NHP4":"10.2","NHP5":"13.1","NHP6":"23.9","NHP7":"1.7","NHP8":"19.5","NHP9":"12.1","NHP10":"21.6","NHP11":"7.3","NHP12":"9.4","NHP13":"3.4","NHP14":"2.5","NHP15":"5","NHP16":"13.4","NHP17":"146.8","NHP18":"78.6","NHP19":"28.1","NHP20":"12","NHP21":"22.6","NHP22":"7.2","NHP23":"15.7","NHP24":"15.9","NHP25":"78.7","NHP26":"29.8","NHP27":"29.6","NHP28":"26.6","NHP29":"48.5","NHP30":"32.4","NHP31":"19.1","NHP32":"22","NHP33":"30.2","NHP34":"32.5","NHP35":"1.8","NHP36":"24.3","NHP37":"51.4","NHP38":"7.5","NHP39":"102.4","NHP40":"119.2","NHP41":"65.2","NHP42":"170.1","NHP43":"55.9","NHP44":"38.5","NHP45":"198.1","NHP46":"333.1","NHP47":"240.1","NHP48":"476.5"},{"Metabolite":"acetylcarnitine","NHP1":"12.724","NHP2":"9.0294","NHP3":"4.924637","NHP4":"2.872567","NHP5":"7.797867","NHP6":"12.31372","NHP7":"21.75905","NHP8":"13.95609","NHP9":"11.49259","NHP10":"5.745522","NHP11":"14.3667","NHP12":"20.52681","NHP13":"25.86701","NHP14":"29.56486","NHP15":"16.00922","NHP16":"","NHP17":"24.63454","NHP18":"80.16621","NHP19":"11.90315","NHP20":"53.41074","NHP21":"38.19565","NHP22":"101.5947","NHP23":"277.5384","NHP24":"363.7578","NHP25":"131.3003","NHP26":"14.77732","NHP27":"37.37351","NHP28":"27.92129","NHP29":"76.87144","NHP30":"17.2412","NHP31":"32.03045","NHP32":"154.8465","NHP33":"13.95609","NHP34":"93.76257","NHP35":"18.06255","NHP36":"61.22813","NHP37":"60.4051","NHP38":"13.13489","NHP39":"270.473","NHP40":"2004.881","NHP41":"162.2875","NHP42":"565.8652","NHP43":"172.6265","NHP44":"121.8065","NHP45":"926.0788","NHP46":"884.9994","NHP47":"447.3904","NHP48":"1379.176"}], "Metabolites":[{"Metabolite":"carnitine","HMDB_ID":"0000062"},{"Metabolite":"acetylcarnitine","HMDB_ID":"0000201"}] } }