{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001179","ANALYSIS_ID":"AN001956","VERSION":"1","CREATED_ON":"May 7, 2019, 12:25 pm"},

"PROJECT":{"PROJECT_TITLE":"Metabolomic analysis of skeletal muscle in young and aged mice","PROJECT_SUMMARY":"To better understand the metabolic changes in skeletal muscle during aging, we performed a metabolomic analysis of skeletal muscle in young (8-week-old) and aged (28-month-old) mice using CE-TOFMS.","INSTITUTE":"Kyoto Prefectural University","LAST_NAME":"Kamei","FIRST_NAME":"Yasutomi","ADDRESS":"1-5 Hangi-cho, Shimogamo, Sakyo-ku Kyoto, Kyoto, Kyoto, 606-8522, Japan","EMAIL":"ran960116@yahoo.co.jp","PHONE":"+81-75-703-5661"},

"STUDY":{"STUDY_TITLE":"Metabolomic analysis of skeletal muscle in young and aged mice","STUDY_SUMMARY":"Sarcopenia is the age-induced, progressive loss of skeletal muscle mass and function, which results in poor muscle performance. To better understand changes in skeletal muscles during sarcopenia, we performed a metabolomic analysis of skeletal muscle in young (8-week-old) and aged (28-month-old) mice using CE-TOFMS. Our data shows that the metabolites including glucose and polyamine metabolism were decreased in aged mice compared with young mice. In addition, neurotransmitter levels were higher in aged mice.","INSTITUTE":"Kyoto Prefectural University","LAST_NAME":"Kamei","FIRST_NAME":"Yasutomi","ADDRESS":"1-5 Hangi-cho, Shimogamo, Sakyo-ku Kyoto, Kyoto, Kyoto, 606-8522, Japan","EMAIL":"ran960116@yahoo.co.jp","PHONE":"+81-75-703-5661"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090","GENOTYPE_STRAIN":"wild type","AGE_OR_AGE_RANGE":"8-week-old and 28-month-old","WEIGHT_OR_WEIGHT_RANGE":"25.4 ± 0.2 g for young and 32.0 ± 0.2 g for aged","GENDER":"Male","ANIMAL_ANIMAL_SUPPLIER":"Shimizu Laboratory Supplies (Kyoto, Japan)","ANIMAL_LIGHT_CYCLE":"12-h light-dark cycle","ANIMAL_FEED":"CE2","SPECIES_GROUP":"C57BL/6J"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"Young-1",
"Factors":{"Age":"8w"}
},
{
"Subject ID":"-",
"Sample ID":"Young-2",
"Factors":{"Age":"8w"}
},
{
"Subject ID":"-",
"Sample ID":"Young-3",
"Factors":{"Age":"8w"}
},
{
"Subject ID":"-",
"Sample ID":"Young-4",
"Factors":{"Age":"8w"}
},
{
"Subject ID":"-",
"Sample ID":"Young-5",
"Factors":{"Age":"8w"}
},
{
"Subject ID":"-",
"Sample ID":"Old-1",
"Factors":{"Age":"28m"}
},
{
"Subject ID":"-",
"Sample ID":"Old-2",
"Factors":{"Age":"28m"}
},
{
"Subject ID":"-",
"Sample ID":"Old-3",
"Factors":{"Age":"28m"}
},
{
"Subject ID":"-",
"Sample ID":"Old-4",
"Factors":{"Age":"28m"}
},
{
"Subject ID":"-",
"Sample ID":"Old-5",
"Factors":{"Age":"28m"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Gastrocnemius muscles were collected and flash-frozen in liquid N2.","SAMPLE_TYPE":"Muscle","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"No specific treatment to mention."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Gastrocnemius muscles of 8-week-old male mice (N=5, young group) and 28-month-old male mice (N=5, aged group) were used for the metabolomic analysis (Human Metabolome Technologies Inc., Tsuruoka, Japan). Frozen muscle specimens were transferred into 500 μL of methanol containing 50 mM external standard. After homogenization by BMSM10N21 (BMS, Tokyo) at 1,500 rpm for 120 s performed 5 times, 500 μL of chloroform and 200 μL of ultrapure water were added to the homogenate. The solution was mixed well and centrifuged at 2,300 × g for 5 min at 4 °C. The resultant water phase was ultrafiltered using a Millipore Ultrafree-MC PLHCC HMT Centrifugal Filter Device, 5 kDa (Millipore, Billerica, MA). The filtrate was dried and then dissolved in 50 μL of ultrapure water. The samples obtained were then subjected to CE-TOFMS analysis using the Agilent CE-TOFMS system (Agilent Technologies, Santa Clara, CA) at 4 °C. The detected peaks were aligned according to their m/z values and normalized migration times. The peaks were mean-centered and scaled using their standard deviations on a per peak basis as a pretreatment."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"None (Direct infusion)","INSTRUMENT_NAME":"none","COLUMN_NAME":"none"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent CE-TOFMS","INSTRUMENT_TYPE":"Other","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"-"},

"MS_METABOLITE_DATA":{
"Units":"fold",

"Data":[{"Metabolite":"Urea","Young-1":"0.287599621","Young-2":"0.26409923","Young-3":"0.234294622","Young-4":"0.229508387","Young-5":"0.218531955","Old-1":"0.296106109","Old-2":"0.339586387","Old-3":"0.259119785","Old-4":"0.162260456","Old-5":"0.387001955"},{"Metabolite":"Ethanolamine","Young-1":"0.00126733","Young-2":"0.001204896","Young-3":"0.001446817","Young-4":"0.001318349","Young-5":"0.001368862","Old-1":"0.000804128","Old-2":"0.000992207","Old-3":"0.001161391","Old-4":"0.0024915","Old-5":"0.000895842"},{"Metabolite":"XC0001","Young-1":"0.000068556","Young-2":"5.92795E-05","Young-3":"3.97936E-05","Young-4":"0","Young-5":"4.00711E-05","Old-1":"0","Old-2":"0","Old-3":"0","Old-4":"0","Old-5":"0"},{"Metabolite":"Gly","Young-1":"0.123926184","Young-2":"0.11469103","Young-3":"0.140758486","Young-4":"0.108449177","Young-5":"0.116073671","Old-1":"0.08372462","Old-2":"0.102114987","Old-3":"0.102054807","Old-4":"0.086934674","Old-5":"0.062390029"},{"Metabolite":"Trimethylamine N-oxide","Young-1":"0.000559534","Young-2":"0.000494186","Young-3":"0.000525544","Young-4":"0.000555851","Young-5":"0.000551867","Old-1":"0.000722767","Old-2":"0.000713368","Old-3":"0.000597128","Old-4":"0.000306451","Old-5":"0.000860187"},{"Metabolite":"4-Methylpyrazole","Young-1":"0","Young-2":"0","Young-3":"0.000157837","Young-4":"0","Young-5":"0.000107863","Old-1":"0","Old-2":"0.000105495","Old-3":"0","Old-4":"0.000133874","Old-5":"0.000138861"},{"Metabolite":"Putrescine","Young-1":"0.000133162","Young-2":"0.000166755","Young-3":"0.00020278","Young-4":"0.000263165","Young-5":"0.000284794","Old-1":"0.000226209","Old-2":"0.000180567","Old-3":"0.000278973","Old-4":"0.000208322","Old-5":"0.000294031"},{"Metabolite":"β-Ala","Young-1":"0.006086193","Young-2":"0.00784155","Young-3":"0.007757955","Young-4":"0.00626067","Young-5":"0.006846053","Old-1":"0.005404896","Old-2":"0.004890269","Old-3":"0.004558951","Old-4":"0.0028018","Old-5":"0.004537008"},{"Metabolite":"Sarcosine","Young-1":"0.001418268","Young-2":"0.00122356","Young-3":"0.00141438","Young-4":"0.001519364","Young-5":"0.001326978","Old-1":"0.001091984","Old-2":"0.00092071","Old-3":"0.000998866","Old-4":"0.000652865","Old-5":"0.001031825"},{"Metabolite":"Ala","Young-1":"0.101164254","Young-2":"0.122208009","Young-3":"0.142220886","Young-4":"0.125909341","Young-5":"0.125992648","Old-1":"0.093919565","Old-2":"0.112475018","Old-3":"0.107963","Old-4":"0.094684026","Old-5":"0.104630175"},{"Metabolite":"Glycerol","Young-1":"0.08445494","Young-2":"0.06144942","Young-3":"0.080058329","Young-4":"0.053967898","Young-5":"0.051787319","Old-1":"0.047820813","Old-2":"0.080659963","Old-3":"0.07566278","Old-4":"0.058109663","Old-5":"0.077650437"},{"Metabolite":"1-Aminocyclopropane-1-carboxylic acid Homoserinelactone","Young-1":"0.000110097","Young-2":"0.000125209","Young-3":"0.000100387","Young-4":"8.97285E-05","Young-5":"0","Old-1":"0.000129326","Old-2":"0.00012833","Old-3":"8.42269E-05","Old-4":"0.000146824","Old-5":"0.000130707"},{"Metabolite":"2-Aminoisobutyric acid 2-Aminobutyric acid","Young-1":"0.001039044","Young-2":"0.001458461","Young-3":"0.001379335","Young-4":"0.000751946","Young-5":"0.001039366","Old-1":"0.00077919","Old-2":"0.000890652","Old-3":"0.000795935","Old-4":"0.000716953","Old-5":"0.001234321"},{"Metabolite":"GABA","Young-1":"0.000431215","Young-2":"0","Young-3":"0","Young-4":"0","Young-5":"0","Old-1":"0.000530397","Old-2":"0","Old-3":"0","Old-4":"0.000469779","Old-5":"0.00056192"},{"Metabolite":"N,N-Dimethylglycine","Young-1":"0.00070684","Young-2":"0","Young-3":"0","Young-4":"0","Young-5":"0","Old-1":"0.000808174","Old-2":"0","Old-3":"0","Old-4":"0","Old-5":"0"},{"Metabolite":"Choline","Young-1":"0.009525971","Young-2":"0.011429352","Young-3":"0.0109684","Young-4":"0.009031119","Young-5":"0.009386239","Old-1":"0.008048935","Old-2":"0.006884241","Old-3":"0.010232444","Old-4":"0.016837883","Old-5":"0.005868219"},{"Metabolite":"Ser","Young-1":"0.014789619","Young-2":"0.017794064","Young-3":"0.022915255","Young-4":"0.019263993","Young-5":"0.018709116","Old-1":"0.016991599","Old-2":"0.019350961","Old-3":"0.01717456","Old-4":"0.023835869","Old-5":"0.01717984"},{"Metabolite":"Diethanolamine","Young-1":"0.000157118","Young-2":"0.000222387","Young-3":"0.000313935","Young-4":"0.000171235","Young-5":"0.000159009","Old-1":"0.000702684","Old-2":"0.000754661","Old-3":"0.000383564","Old-4":"0.000362917","Old-5":"0.000304983"},{"Metabolite":"Hypotaurine","Young-1":"0.004155093","Young-2":"0.005103468","Young-3":"0.004426257","Young-4":"0.003625655","Young-5":"0.002887805","Old-1":"0.003532545","Old-2":"0.003975177","Old-3":"0.003579741","Old-4":"0.009307362","Old-5":"0.002578003"},{"Metabolite":"Histamine","Young-1":"0.000955005","Young-2":"0.001298857","Young-3":"0.000914451","Young-4":"0.000986496","Young-5":"0.000759942","Old-1":"0.002514345","Old-2":"0.002854493","Old-3":"0.002227341","Old-4":"0.003168342","Old-5":"0.002225614"},{"Metabolite":"Creatinine","Young-1":"0.004086664","Young-2":"0.003781229","Young-3":"0.004335902","Young-4":"0.003824922","Young-5":"0.003759369","Old-1":"0.003242482","Old-2":"0.003639431","Old-3":"0.003755348","Old-4":"0.00351002","Old-5":"0.004733428"},{"Metabolite":"Pro","Young-1":"0.024088132","Young-2":"0.033669376","Young-3":"0.035476136","Young-4":"0.026420912","Young-5":"0.028663332","Old-1":"0.024026674","Old-2":"0.028646631","Old-3":"0.024001129","Old-4":"0.026841328","Old-5":"0.02520804"},{"Metabolite":"Val","Young-1":"0.026417762","Young-2":"0.03816203","Young-3":"0.033494546","Young-4":"0.029692767","Young-5":"0.029840161","Old-1":"0.034111273","Old-2":"0.036628063","Old-3":"0.026485018","Old-4":"0.027756687","Old-5":"0.035040555"},{"Metabolite":"Betaine","Young-1":"0.010109525","Young-2":"0.013145596","Young-3":"0.011037487","Young-4":"0.008812625","Young-5":"0.008257066","Old-1":"0.009648143","Old-2":"0.011151462","Old-3":"0.010724917","Old-4":"0.016942155","Old-5":"0.00837907"},{"Metabolite":"Thr","Young-1":"0.016814888","Young-2":"0.025212363","Young-3":"0.027832144","Young-4":"0.023261768","Young-5":"0.020706296","Old-1":"0.023645171","Old-2":"0.023878491","Old-3":"0.01793402","Old-4":"0.018281779","Old-5":"0.022651062"},{"Metabolite":"Homoserine","Young-1":"0.00019643","Young-2":"0.000357893","Young-3":"0.000295877","Young-4":"0.000265884","Young-5":"0","Old-1":"0","Old-2":"0.000247541","Old-3":"0","Old-4":"0","Old-5":"0"},{"Metabolite":"Nicotinamide","Young-1":"0.01081095","Young-2":"0.012876872","Young-3":"0.010330966","Young-4":"0.013992926","Young-5":"0.013291394","Old-1":"0.011179231","Old-2":"0.013157034","Old-3":"0.010266792","Old-4":"0.010208881","Old-5":"0.011278205"},{"Metabolite":"Taurine","Young-1":"0.243772267","Young-2":"0.262383701","Young-3":"0.255182674","Young-4":"0.243106339","Young-5":"0.248392789","Old-1":"0.269103917","Old-2":"0.278780274","Old-3":"0.247790071","Old-4":"0.274935202","Old-5":"0.286509872"},{"Metabolite":"1-Methylhistamine","Young-1":"3.81008E-05","Young-2":"3.18922E-05","Young-3":"3.41757E-05","Young-4":"3.31465E-05","Young-5":"2.93318E-05","Old-1":"0.000188618","Old-2":"0.000200192","Old-3":"0.000117351","Old-4":"0.000167768","Old-5":"0.000151332"},{"Metabolite":"XC0016","Young-1":"0.00027913","Young-2":"0.000211089","Young-3":"0.00025488","Young-4":"0.000255267","Young-5":"0.000265865","Old-1":"0.000330597","Old-2":"0.000252867","Old-3":"0.000316995","Old-4":"0.000373795","Old-5":"0.00039244"},{"Metabolite":"Pipecolic 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}

}