{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001236","ANALYSIS_ID":"AN002054","VERSION":"1","CREATED_ON":"August 13, 2019, 3:36 pm"},

"PROJECT":{"PROJECT_TITLE":"Metabolomic adaptations and correlates of survival to immune checkpoint blockade","PROJECT_TYPE":"Serum metabolomics","PROJECT_SUMMARY":"To investigate the metabolic alterations in response to immune checkpoint blockade, we comprehensively profiled serum metabolites in advanced melanoma and renal cell carcinoma patients treated with nivolumab, an antibody against programmed cell death protein 1 (PD1). We identified serum kynurenine/tryptophan ratio increases as an adaptive resistance mechanism associated with worse overall survival. This advocates for patient stratification and metabolic monitoring in immunotherapy clinical trials including those combining PD1 blockade with IDO/TDO inhibitors.","INSTITUTE":"Broad Institute of MIT and Harvard","DEPARTMENT":"Metabolomics Platform","LAST_NAME":"Clish","FIRST_NAME":"Clary","ADDRESS":"415 Main Street, Cambridge, MA, 02142, USA","EMAIL":"clary@broadinstitute.org","PHONE":"617-714-7654","FUNDING_SOURCE":"NIH KL2 TR001100; Conquer Cancer Foundation ASCO Career Development Award; Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (grant number: SU2C-AACR-DT22-17); the Dana-Farber/Harvard Cancer Center Kidney Cancer program; NIGMS GM03862;, Kidney SPORE P50CA101942-1; the Trust Family, Michael Brigham, and Loker Pinard Funds for Kidney Cancer Research at Dana-Farber Cancer Institute; the BMS II-ON consortium; and the AACR KureIt Grant for Kidney Cancer","CONTRIBUTORS":"Haoxin Li, Kevin Bullock, Carino Gurjao, David Braun, Sachet Shukla, Dominick Bossé, Aly-Khan A. Lalani, Shuba Gopal, Chelsea Jin, Christine Horak, Megan Wind-Rotolo, Sabina Signoretti, David F. McDermott, Gordon J. Freeman, Eliezer M. Van Allen, Stuart L. Schreiber, F. Stephen Hodi, William R. Sellers, Levi A. Garraway, Clary Clish, Toni K. Choueiri, Marios Giannakis"},

"STUDY":{"STUDY_TITLE":"Metabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part II","STUDY_SUMMARY":"Inhibition of immune-checkpoint targets including PD1 is clinically effective in a variety of cancers. However, only a subset of patients respond and complete response remains uncommon. Given the known role of metabolites in modulating immunity, we sought to understand how individual patients’ metabolic activities adapt to PD1 immune checkpoint blockade and how they associate with therapeutic benefits. To this end, we profiled metabolites in pre- and multiple on-treatment patient serum samples from three independent immunotherapy trials using hydrophilic interaction liquid chromatography coupled with either triple quadrupole MS multiple reaction monitoring or high resolution full scan MS detection. The study consisted of two Phase I trials (CA209-038, NCT01621490; CA209-009, NCT01358721) which included 78 patients with advanced melanoma and 91 patients with metastatic renal cell carcinoma (RCC) treated with nivolumab. To investigate the generalizability of our results, we also analyzed a large randomized Phase III trial (CheckMate 025, NCT01668784) with 743 RCC patients, among which 394 received nivolumab and 349 received everolimus. V600E is the most common BRAF mutation in melanoma and BRAF_V600E indicates the mutation status.","INSTITUTE":"Broad Institute of MIT and Harvard","LAST_NAME":"Clish","FIRST_NAME":"Clary","ADDRESS":"415 Main St, Cambridge, MA 02142","EMAIL":"clary@broadinstitute.org","PHONE":"617-714-7654","NUM_GROUPS":"1","TOTAL_SUBJECTS":"91","NUM_MALES":"61","NUM_FEMALES":"30"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"CA209009-1-20",
"Sample ID":"CA209009-1-20_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"35.500","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"76","Sex":"M","Race":"WHITE","raw data file name":"0001_Marios_RCC_HP-000100020-1.raw"}
},
{
"Subject ID":"CA209009-1-32",
"Sample ID":"CA209009-1-32_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"8.000","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"65","Sex":"M","Race":"WHITE","raw data file name":"0004_Marios_RCC_HP-000100032-1.raw"}
},
{
"Subject ID":"CA209009-1-43",
"Sample ID":"CA209009-1-43_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.267","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"74","Sex":"M","Race":"WHITE","raw data file name":"0007_Marios_RCC_HP-000100043-1.raw"}
},
{
"Subject ID":"CA209009-1-62",
"Sample ID":"CA209009-1-62_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"3.533","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"48","Sex":"F","Race":"WHITE","raw data file name":"0010_Marios_RCC_HP-000100062-1.raw"}
},
{
"Subject ID":"CA209009-1-72",
"Sample ID":"CA209009-1-72_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"9.433","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"58","Sex":"M","Race":"WHITE","raw data file name":"0013_Marios_RCC_HP-000100072-1.raw"}
},
{
"Subject ID":"CA209009-1-86",
"Sample ID":"CA209009-1-86_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"15.467","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"71","Sex":"M","Race":"WHITE","raw data file name":"0016_Marios_RCC_HP-000100086-1.raw"}
},
{
"Subject ID":"CA209009-1-118",
"Sample ID":"CA209009-1-118_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"5.900","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"82","Sex":"M","Race":"WHITE","raw data file name":"0019_Marios_RCC_HP-000100118-1.raw"}
},
{
"Subject ID":"CA209009-2-42",
"Sample ID":"CA209009-2-42_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"2.700","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"42","Sex":"M","Race":"WHITE","raw data file name":"0022_Marios_RCC_HP-000200042-1.raw"}
},
{
"Subject ID":"CA209009-2-48",
"Sample ID":"CA209009-2-48_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"32.767","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"62","Sex":"M","Race":"WHITE","raw data file name":"0023_Marios_RCC_HP-000200048-1.raw"}
},
{
"Subject ID":"CA209009-2-58",
"Sample ID":"CA209009-2-58_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"32.933","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"55","Sex":"F","Race":"OTHER","raw data file name":"0026_Marios_RCC_HP-000200058-1.raw"}
},
{
"Subject ID":"CA209009-2-64",
"Sample ID":"CA209009-2-64_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"25.533","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"59","Sex":"M","Race":"WHITE","raw data file name":"0029_Marios_RCC_HP-000200064-1.raw"}
},
{
"Subject ID":"CA209009-2-84",
"Sample ID":"CA209009-2-84_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"22.667","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"55","Sex":"F","Race":"OTHER","raw data file name":"0032_Marios_RCC_HP-000200084-1.raw"}
},
{
"Subject ID":"CA209009-2-85",
"Sample ID":"CA209009-2-85_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"23.733","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"36","Sex":"M","Race":"WHITE","raw data file name":"0035_Marios_RCC_HP-000200085-1.raw"}
},
{
"Subject ID":"CA209009-2-102",
"Sample ID":"CA209009-2-102_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"5.500","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"M","Race":"WHITE","raw data file name":"0037_Marios_RCC_HP-000200102-1.raw"}
},
{
"Subject ID":"CA209009-3-15",
"Sample ID":"CA209009-3-15_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"33.767","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"73","Sex":"F","Race":"WHITE","raw data file name":"0039_Marios_RCC_HP-000300015-1.raw"}
},
{
"Subject ID":"CA209009-3-26",
"Sample ID":"CA209009-3-26_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"1.100","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"55","Sex":"M","Race":"WHITE","raw data file name":"0042_Marios_RCC_HP-000300026-1.raw"}
},
{
"Subject ID":"CA209009-3-114",
"Sample ID":"CA209009-3-114_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"11.333","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"57","Sex":"F","Race":"WHITE","raw data file name":"0043_Marios_RCC_HP-000300114-1.raw"}
},
{
"Subject ID":"CA209009-3-117",
"Sample ID":"CA209009-3-117_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"2.133","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"58","Sex":"M","Race":"WHITE","raw data file name":"0046_Marios_RCC_HP-000300117-1.raw"}
},
{
"Subject ID":"CA209009-4-49",
"Sample ID":"CA209009-4-49_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"20.167","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"M","Race":"WHITE","raw data file name":"0050_Marios_RCC_HP-000400049-1.raw"}
},
{
"Subject ID":"CA209009-4-54",
"Sample ID":"CA209009-4-54_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"32.533","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"65","Sex":"F","Race":"WHITE","raw data file name":"0053_Marios_RCC_HP-000400054-1.raw"}
},
{
"Subject ID":"CA209009-4-68",
"Sample ID":"CA209009-4-68_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"24.667","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"69","Sex":"M","Race":"WHITE","raw data file name":"0056_Marios_RCC_HP-000400068-1.raw"}
},
{
"Subject ID":"CA209009-4-95",
"Sample ID":"CA209009-4-95_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"3.067","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"55","Sex":"M","Race":"WHITE","raw data file name":"0058_Marios_RCC_HP-000400095-1.raw"}
},
{
"Subject ID":"CA209009-5-1",
"Sample ID":"CA209009-5-1_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"1.433","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"49","Sex":"M","Race":"WHITE","raw data file name":"0060_Marios_RCC_HP-000500001-1.raw"}
},
{
"Subject ID":"CA209009-5-2",
"Sample ID":"CA209009-5-2_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"1.033","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"48","Sex":"M","Race":"WHITE","raw data file name":"0062_Marios_RCC_HP-000500002-1.raw"}
},
{
"Subject ID":"CA209009-5-3",
"Sample ID":"CA209009-5-3_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"1.433","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"57","Sex":"F","Race":"WHITE","raw data file name":"0063_Marios_RCC_HP-000500003-1.raw"}
},
{
"Subject ID":"CA209009-5-4",
"Sample ID":"CA209009-5-4_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"30.467","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"65","Sex":"M","Race":"WHITE","raw data file name":"0065_Marios_RCC_HP-000500004-1.raw"}
},
{
"Subject ID":"CA209009-5-6",
"Sample ID":"CA209009-5-6_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"5.167","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"59","Sex":"F","Race":"WHITE","raw data file name":"0068_Marios_RCC_HP-000500006-1.raw"}
},
{
"Subject ID":"CA209009-5-17",
"Sample ID":"CA209009-5-17_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"5.633","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"55","Sex":"M","Race":"WHITE","raw data file name":"0071_Marios_RCC_HP-000500017-1.raw"}
},
{
"Subject ID":"CA209009-5-18",
"Sample ID":"CA209009-5-18_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"3.700","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"68","Sex":"M","Race":"WHITE","raw data file name":"0074_Marios_RCC_HP-000500018-1.raw"}
},
{
"Subject ID":"CA209009-5-21",
"Sample ID":"CA209009-5-21_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"11.633","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"M","Race":"WHITE","raw data file name":"0077_Marios_RCC_HP-000500021-1.raw"}
},
{
"Subject ID":"CA209009-5-22",
"Sample ID":"CA209009-5-22_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"6.567","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"63","Sex":"M","Race":"WHITE","raw data file name":"0079_Marios_RCC_HP-000500022-1.raw"}
},
{
"Subject ID":"CA209009-5-23",
"Sample ID":"CA209009-5-23_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"4.967","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"66","Sex":"M","Race":"WHITE","raw data file name":"0082_Marios_RCC_HP-000500023-1.raw"}
},
{
"Subject ID":"CA209009-5-28",
"Sample ID":"CA209009-5-28_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"1.433","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"47","Sex":"M","Race":"WHITE","raw data file name":"0085_Marios_RCC_HP-000500028-1.raw"}
},
{
"Subject ID":"CA209009-5-29",
"Sample ID":"CA209009-5-29_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"31.233","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"67","Sex":"M","Race":"WHITE","raw data file name":"0087_Marios_RCC_HP-000500029-1.raw"}
},
{
"Subject ID":"CA209009-5-41",
"Sample ID":"CA209009-5-41_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"6.500","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"66","Sex":"M","Race":"WHITE","raw data file name":"0090_Marios_RCC_HP-000500041-1.raw"}
},
{
"Subject ID":"CA209009-5-50",
"Sample ID":"CA209009-5-50_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.733","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"63","Sex":"F","Race":"WHITE","raw data file name":"0093_Marios_RCC_HP-000500050-1.raw"}
},
{
"Subject ID":"CA209009-5-63",
"Sample ID":"CA209009-5-63_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"6.300","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"71","Sex":"F","Race":"WHITE","raw data file name":"0096_Marios_RCC_HP-000500063-1.raw"}
},
{
"Subject ID":"CA209009-5-73",
"Sample ID":"CA209009-5-73_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"5.933","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"77","Sex":"M","Race":"WHITE","raw data file name":"0097_Marios_RCC_HP-000500073-1.raw"}
},
{
"Subject ID":"CA209009-5-106",
"Sample ID":"CA209009-5-106_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"29.000","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"61","Sex":"F","Race":"WHITE","raw data file name":"0100_Marios_RCC_HP-000500106-1.raw"}
},
{
"Subject ID":"CA209009-6-39",
"Sample ID":"CA209009-6-39_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"10.200","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"72","Sex":"M","Race":"WHITE","raw data file name":"0103_Marios_RCC_HP-000600039-1.raw"}
},
{
"Subject ID":"CA209009-6-99",
"Sample ID":"CA209009-6-99_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"1.367","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"50","Sex":"M","Race":"WHITE","raw data file name":"0106_Marios_RCC_HP-000600099-1.raw"}
},
{
"Subject ID":"CA209009-8-100",
"Sample ID":"CA209009-8-100_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"26.600","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"58","Sex":"F","Race":"WHITE","raw data file name":"0107_Marios_RCC_HP-000800100-1.raw"}
},
{
"Subject ID":"CA209009-8-105",
"Sample ID":"CA209009-8-105_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"3.933","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"M","Race":"WHITE","raw data file name":"0110_Marios_RCC_HP-000800105-1.raw"}
},
{
"Subject ID":"CA209009-9-27",
"Sample ID":"CA209009-9-27_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"32.267","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"59","Sex":"M","Race":"WHITE","raw data file name":"0112_Marios_RCC_HP-000900027-1.raw"}
},
{
"Subject ID":"CA209009-9-30",
"Sample ID":"CA209009-9-30_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"12.167","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"F","Race":"WHITE","raw data file name":"0114_Marios_RCC_HP-000900030-1.raw"}
},
{
"Subject ID":"CA209009-9-34",
"Sample ID":"CA209009-9-34_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"31.900","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"61","Sex":"F","Race":"WHITE","raw data file name":"0117_Marios_RCC_HP-000900034-1.raw"}
},
{
"Subject ID":"CA209009-9-45",
"Sample ID":"CA209009-9-45_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"31.767","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"M","Race":"WHITE","raw data file name":"0120_Marios_RCC_HP-000900045-1.raw"}
},
{
"Subject ID":"CA209009-9-47",
"Sample ID":"CA209009-9-47_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"33.433","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"69","Sex":"M","Race":"WHITE","raw data file name":"0123_Marios_RCC_HP-000900047-1.raw"}
},
{
"Subject ID":"CA209009-9-52",
"Sample ID":"CA209009-9-52_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"33.167","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"63","Sex":"F","Race":"WHITE","raw data file name":"0126_Marios_RCC_HP-000900052-1.raw"}
},
{
"Subject ID":"CA209009-9-66",
"Sample ID":"CA209009-9-66_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"15.667","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"47","Sex":"M","Race":"WHITE","raw data file name":"0128_Marios_RCC_HP-000900066-1.raw"}
},
{
"Subject ID":"CA209009-9-74",
"Sample ID":"CA209009-9-74_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"14.667","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"67","Sex":"M","Race":"WHITE","raw data file name":"0131_Marios_RCC_HP-000900074-1.raw"}
},
{
"Subject ID":"CA209009-9-88",
"Sample ID":"CA209009-9-88_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"29.267","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"63","Sex":"F","Race":"WHITE","raw data file name":"0134_Marios_RCC_HP-000900088-1.raw"}
},
{
"Subject ID":"CA209009-9-97",
"Sample ID":"CA209009-9-97_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"29.033","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"54","Sex":"M","Race":"WHITE","raw data file name":"0137_Marios_RCC_HP-000900097-1.raw"}
},
{
"Subject ID":"CA209009-9-119",
"Sample ID":"CA209009-9-119_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"25.767","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"72","Sex":"M","Race":"WHITE","raw data file name":"0140_Marios_RCC_HP-000900119-1.raw"}
},
{
"Subject ID":"CA209009-10-112",
"Sample ID":"CA209009-10-112_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"25.733","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"54","Sex":"M","Race":"OTHER","raw data file name":"0143_Marios_RCC_HP-001000112-1.raw"}
},
{
"Subject ID":"CA209009-11-5",
"Sample ID":"CA209009-11-5_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"16.400","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"63","Sex":"F","Race":"WHITE","raw data file name":"0146_Marios_RCC_HP-001100005-1.raw"}
},
{
"Subject ID":"CA209009-11-8",
"Sample ID":"CA209009-11-8_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"35.033","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"M","Race":"WHITE","raw data file name":"0149_Marios_RCC_HP-001100008-1.raw"}
},
{
"Subject ID":"CA209009-11-10",
"Sample ID":"CA209009-11-10_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"35.267","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"F","Race":"WHITE","raw data file name":"0152_Marios_RCC_HP-001100010-1.raw"}
},
{
"Subject ID":"CA209009-11-11",
"Sample ID":"CA209009-11-11_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"34.133","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"50","Sex":"M","Race":"WHITE","raw data file name":"0155_Marios_RCC_HP-001100011-1.raw"}
},
{
"Subject ID":"CA209009-11-12",
"Sample ID":"CA209009-11-12_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"5.967","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"69","Sex":"F","Race":"WHITE","raw data file name":"0158_Marios_RCC_HP-001100012-1.raw"}
},
{
"Subject ID":"CA209009-11-13",
"Sample ID":"CA209009-11-13_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"36.467","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"F","Race":"WHITE","raw data file name":"0160_Marios_RCC_HP-001100013-1.raw"}
},
{
"Subject ID":"CA209009-11-14",
"Sample ID":"CA209009-11-14_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"34.167","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"59","Sex":"M","Race":"WHITE","raw data file name":"0163_Marios_RCC_HP-001100014-1.raw"}
},
{
"Subject ID":"CA209009-11-24",
"Sample ID":"CA209009-11-24_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"2.067","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"70","Sex":"M","Race":"WHITE","raw data file name":"0166_Marios_RCC_HP-001100024-1.raw"}
},
{
"Subject ID":"CA209009-11-25",
"Sample ID":"CA209009-11-25_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"5.567","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"72","Sex":"F","Race":"WHITE","raw data file name":"0168_Marios_RCC_HP-001100025-1.raw"}
},
{
"Subject ID":"CA209009-11-38",
"Sample ID":"CA209009-11-38_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"31.833","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"69","Sex":"M","Race":"WHITE","raw data file name":"0171_Marios_RCC_HP-001100038-1.raw"}
},
{
"Subject ID":"CA209009-11-40",
"Sample ID":"CA209009-11-40_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.467","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"32","Sex":"M","Race":"WHITE","raw data file name":"0174_Marios_RCC_HP-001100040-1.raw"}
},
{
"Subject ID":"CA209009-11-56",
"Sample ID":"CA209009-11-56_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"33.067","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"62","Sex":"F","Race":"WHITE","raw data file name":"0177_Marios_RCC_HP-001100056-1.raw"}
},
{
"Subject ID":"CA209009-11-57",
"Sample ID":"CA209009-11-57_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.300","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"48","Sex":"M","Race":"WHITE","raw data file name":"0180_Marios_RCC_HP-001100057-1.raw"}
},
{
"Subject ID":"CA209009-11-71",
"Sample ID":"CA209009-11-71_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"31.800","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"57","Sex":"M","Race":"WHITE","raw data file name":"0183_Marios_RCC_HP-001100071-1.raw"}
},
{
"Subject ID":"CA209009-11-79",
"Sample ID":"CA209009-11-79_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"29.100","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"61","Sex":"F","Race":"WHITE","raw data file name":"0186_Marios_RCC_HP-001100079-1.raw"}
},
{
"Subject ID":"CA209009-11-93",
"Sample ID":"CA209009-11-93_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"22.800","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"M","Race":"WHITE","raw data file name":"0189_Marios_RCC_HP-001100093-1.raw"}
},
{
"Subject ID":"CA209009-12-115",
"Sample ID":"CA209009-12-115_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"12.200","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"M","Race":"WHITE","raw data file name":"0191_Marios_RCC_HP-001200115-1.raw"}
},
{
"Subject ID":"CA209009-13-36",
"Sample ID":"CA209009-13-36_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"24.700","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"69","Sex":"F","Race":"WHITE","raw data file name":"0194_Marios_RCC_HP-001300036-1.raw"}
},
{
"Subject ID":"CA209009-13-51",
"Sample ID":"CA209009-13-51_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.233","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"45","Sex":"M","Race":"WHITE","raw data file name":"0195_Marios_RCC_HP-001300051-1.raw"}
},
{
"Subject ID":"CA209009-13-90",
"Sample ID":"CA209009-13-90_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"16.633","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"54","Sex":"M","Race":"OTHER","raw data file name":"0198_Marios_RCC_HP-001300090-1.raw"}
},
{
"Subject ID":"CA209009-13-96",
"Sample ID":"CA209009-13-96_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"19.400","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"75","Sex":"F","Race":"WHITE","raw data file name":"0201_Marios_RCC_HP-001300096-1.raw"}
},
{
"Subject ID":"CA209009-13-103",
"Sample ID":"CA209009-13-103_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"28.733","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"51","Sex":"M","Race":"OTHER","raw data file name":"0204_Marios_RCC_HP-001300103-1.raw"}
},
{
"Subject ID":"CA209009-13-111",
"Sample ID":"CA209009-13-111_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"27.800","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"68","Sex":"M","Race":"WHITE","raw data file name":"0207_Marios_RCC_HP-001300111-1.raw"}
},
{
"Subject ID":"CA209009-14-59",
"Sample ID":"CA209009-14-59_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"33.033","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"64","Sex":"M","Race":"WHITE","raw data file name":"0210_Marios_RCC_HP-001400059-1.raw"}
},
{
"Subject ID":"CA209009-14-69",
"Sample ID":"CA209009-14-69_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"10.100","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"40","Sex":"F","Race":"WHITE","raw data file name":"0213_Marios_RCC_HP-001400069-1.raw"}
},
{
"Subject ID":"CA209009-14-80",
"Sample ID":"CA209009-14-80_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"4.900","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"61","Sex":"M","Race":"WHITE","raw data file name":"0215_Marios_RCC_HP-001400080-1.raw"}
},
{
"Subject ID":"CA209009-14-87",
"Sample ID":"CA209009-14-87_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"11.667","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"62","Sex":"F","Race":"WHITE","raw data file name":"0218_Marios_RCC_HP-001400087-1.raw"}
},
{
"Subject ID":"CA209009-14-89",
"Sample ID":"CA209009-14-89_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"9.767","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"78","Sex":"M","Race":"WHITE","raw data file name":"0221_Marios_RCC_HP-001400089-1.raw"}
},
{
"Subject ID":"CA209009-14-98",
"Sample ID":"CA209009-14-98_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"13.267","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"65","Sex":"M","Race":"WHITE","raw data file name":"0224_Marios_RCC_HP-001400098-1.raw"}
},
{
"Subject ID":"CA209009-14-107",
"Sample ID":"CA209009-14-107_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"27.233","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"82","Sex":"M","Race":"WHITE","raw data file name":"0227_Marios_RCC_HP-001400107-1.raw"}
},
{
"Subject ID":"CA209009-15-75",
"Sample ID":"CA209009-15-75_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"27.367","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"70","Sex":"F","Race":"WHITE","raw data file name":"0230_Marios_RCC_HP-001500075-1.raw"}
},
{
"Subject ID":"CA209009-15-76",
"Sample ID":"CA209009-15-76_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"22.067","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"42","Sex":"M","Race":"WHITE","raw data file name":"0233_Marios_RCC_HP-001500076-1.raw"}
},
{
"Subject ID":"CA209009-15-77",
"Sample ID":"CA209009-15-77_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"4.400","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"50","Sex":"M","Race":"WHITE","raw data file name":"0236_Marios_RCC_HP-001500077-1.raw"}
},
{
"Subject ID":"CA209009-15-81",
"Sample ID":"CA209009-15-81_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"30.400","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"45","Sex":"F","Race":"WHITE","raw data file name":"0238_Marios_RCC_HP-001500081-1.raw"}
},
{
"Subject ID":"CA209009-15-83",
"Sample ID":"CA209009-15-83_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"16.200","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"46","Sex":"M","Race":"WHITE","raw data file name":"0241_Marios_RCC_HP-001500083-1.raw"}
},
{
"Subject ID":"CA209009-15-94",
"Sample ID":"CA209009-15-94_baseline",
"Factors":{"Time point":"baseline","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"30.400","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"41","Sex":"F","Race":"WHITE","raw data file name":"0243_Marios_RCC_HP-001500094-1.raw"}
},
{
"Subject ID":"CA209009-1-20",
"Sample ID":"CA209009-1-20_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"35.500","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"76","Sex":"M","Race":"WHITE","raw data file name":"0002_Marios_RCC_HP-000100020-2.raw"}
},
{
"Subject ID":"CA209009-1-32",
"Sample ID":"CA209009-1-32_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"8.000","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"65","Sex":"M","Race":"WHITE","raw data file name":"0005_Marios_RCC_HP-000100032-2.raw"}
},
{
"Subject ID":"CA209009-1-43",
"Sample ID":"CA209009-1-43_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
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},
{
"Subject ID":"CA209009-1-62",
"Sample ID":"CA209009-1-62_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
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},
{
"Subject ID":"CA209009-1-72",
"Sample ID":"CA209009-1-72_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"9.433","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"58","Sex":"M","Race":"WHITE","raw data file name":"0014_Marios_RCC_HP-000100072-2.raw"}
},
{
"Subject ID":"CA209009-1-86",
"Sample ID":"CA209009-1-86_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"15.467","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"71","Sex":"M","Race":"WHITE","raw data file name":"0017_Marios_RCC_HP-000100086-2.raw"}
},
{
"Subject ID":"CA209009-1-118",
"Sample ID":"CA209009-1-118_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"5.900","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"82","Sex":"M","Race":"WHITE","raw data file name":"0020_Marios_RCC_HP-000100118-2.raw"}
},
{
"Subject ID":"CA209009-2-48",
"Sample ID":"CA209009-2-48_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"32.767","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"62","Sex":"M","Race":"WHITE","raw data file name":"0024_Marios_RCC_HP-000200048-2.raw"}
},
{
"Subject ID":"CA209009-2-58",
"Sample ID":"CA209009-2-58_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"32.933","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"55","Sex":"F","Race":"OTHER","raw data file name":"0027_Marios_RCC_HP-000200058-2.raw"}
},
{
"Subject ID":"CA209009-2-64",
"Sample ID":"CA209009-2-64_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"25.533","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"59","Sex":"M","Race":"WHITE","raw data file name":"0030_Marios_RCC_HP-000200064-2.raw"}
},
{
"Subject ID":"CA209009-2-84",
"Sample ID":"CA209009-2-84_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"22.667","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"55","Sex":"F","Race":"OTHER","raw data file name":"0033_Marios_RCC_HP-000200084-2.raw"}
},
{
"Subject ID":"CA209009-2-85",
"Sample ID":"CA209009-2-85_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"23.733","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"36","Sex":"M","Race":"WHITE","raw data file name":"0036_Marios_RCC_HP-000200085-2.raw"}
},
{
"Subject ID":"CA209009-2-102",
"Sample ID":"CA209009-2-102_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"5.500","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"M","Race":"WHITE","raw data file name":"0038_Marios_RCC_HP-000200102-2.raw"}
},
{
"Subject ID":"CA209009-3-15",
"Sample ID":"CA209009-3-15_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"33.767","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"73","Sex":"F","Race":"WHITE","raw data file name":"0040_Marios_RCC_HP-000300015-2.raw"}
},
{
"Subject ID":"CA209009-3-114",
"Sample ID":"CA209009-3-114_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"11.333","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"57","Sex":"F","Race":"WHITE","raw data file name":"0044_Marios_RCC_HP-000300114-2.raw"}
},
{
"Subject ID":"CA209009-3-117",
"Sample ID":"CA209009-3-117_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"2.133","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"58","Sex":"M","Race":"WHITE","raw data file name":"0047_Marios_RCC_HP-000300117-2.raw"}
},
{
"Subject ID":"CA209009-4-49",
"Sample ID":"CA209009-4-49_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"20.167","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"M","Race":"WHITE","raw data file name":"0051_Marios_RCC_HP-000400049-2.raw"}
},
{
"Subject ID":"CA209009-4-54",
"Sample ID":"CA209009-4-54_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"32.533","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"65","Sex":"F","Race":"WHITE","raw data file name":"0054_Marios_RCC_HP-000400054-2.raw"}
},
{
"Subject ID":"CA209009-4-68",
"Sample ID":"CA209009-4-68_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"24.667","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"69","Sex":"M","Race":"WHITE","raw data file name":"0057_Marios_RCC_HP-000400068-2.raw"}
},
{
"Subject ID":"CA209009-4-95",
"Sample ID":"CA209009-4-95_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"3.067","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"55","Sex":"M","Race":"WHITE","raw data file name":"0059_Marios_RCC_HP-000400095-2.raw"}
},
{
"Subject ID":"CA209009-5-1",
"Sample ID":"CA209009-5-1_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"1.433","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"49","Sex":"M","Race":"WHITE","raw data file name":"0061_Marios_RCC_HP-000500001-2.raw"}
},
{
"Subject ID":"CA209009-5-3",
"Sample ID":"CA209009-5-3_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
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},
{
"Subject ID":"CA209009-5-4",
"Sample ID":"CA209009-5-4_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"30.467","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"65","Sex":"M","Race":"WHITE","raw data file name":"0066_Marios_RCC_HP-000500004-2.raw"}
},
{
"Subject ID":"CA209009-5-6",
"Sample ID":"CA209009-5-6_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"5.167","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"59","Sex":"F","Race":"WHITE","raw data file name":"0069_Marios_RCC_HP-000500006-2.raw"}
},
{
"Subject ID":"CA209009-5-17",
"Sample ID":"CA209009-5-17_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"5.633","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"55","Sex":"M","Race":"WHITE","raw data file name":"0072_Marios_RCC_HP-000500017-2.raw"}
},
{
"Subject ID":"CA209009-5-18",
"Sample ID":"CA209009-5-18_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"3.700","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"68","Sex":"M","Race":"WHITE","raw data file name":"0075_Marios_RCC_HP-000500018-2.raw"}
},
{
"Subject ID":"CA209009-5-21",
"Sample ID":"CA209009-5-21_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"11.633","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"M","Race":"WHITE","raw data file name":"0078_Marios_RCC_HP-000500021-2.raw"}
},
{
"Subject ID":"CA209009-5-22",
"Sample ID":"CA209009-5-22_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"6.567","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"63","Sex":"M","Race":"WHITE","raw data file name":"0080_Marios_RCC_HP-000500022-2.raw"}
},
{
"Subject ID":"CA209009-5-23",
"Sample ID":"CA209009-5-23_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"4.967","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"66","Sex":"M","Race":"WHITE","raw data file name":"0083_Marios_RCC_HP-000500023-2.raw"}
},
{
"Subject ID":"CA209009-5-28",
"Sample ID":"CA209009-5-28_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"1.433","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"47","Sex":"M","Race":"WHITE","raw data file name":"0086_Marios_RCC_HP-000500028-2.raw"}
},
{
"Subject ID":"CA209009-5-29",
"Sample ID":"CA209009-5-29_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"31.233","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"67","Sex":"M","Race":"WHITE","raw data file name":"0088_Marios_RCC_HP-000500029-2.raw"}
},
{
"Subject ID":"CA209009-5-41",
"Sample ID":"CA209009-5-41_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"6.500","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"66","Sex":"M","Race":"WHITE","raw data file name":"0091_Marios_RCC_HP-000500041-2.raw"}
},
{
"Subject ID":"CA209009-5-50",
"Sample ID":"CA209009-5-50_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.733","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"63","Sex":"F","Race":"WHITE","raw data file name":"0094_Marios_RCC_HP-000500050-2.raw"}
},
{
"Subject ID":"CA209009-5-73",
"Sample ID":"CA209009-5-73_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"5.933","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"77","Sex":"M","Race":"WHITE","raw data file name":"0098_Marios_RCC_HP-000500073-2.raw"}
},
{
"Subject ID":"CA209009-5-106",
"Sample ID":"CA209009-5-106_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"29.000","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"61","Sex":"F","Race":"WHITE","raw data file name":"0101_Marios_RCC_HP-000500106-2.raw"}
},
{
"Subject ID":"CA209009-6-39",
"Sample ID":"CA209009-6-39_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"10.200","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"72","Sex":"M","Race":"WHITE","raw data file name":"0104_Marios_RCC_HP-000600039-2.raw"}
},
{
"Subject ID":"CA209009-8-100",
"Sample ID":"CA209009-8-100_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"26.600","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"58","Sex":"F","Race":"WHITE","raw data file name":"0108_Marios_RCC_HP-000800100-2.raw"}
},
{
"Subject ID":"CA209009-8-105",
"Sample ID":"CA209009-8-105_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"3.933","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"M","Race":"WHITE","raw data file name":"0111_Marios_RCC_HP-000800105-2.raw"}
},
{
"Subject ID":"CA209009-9-27",
"Sample ID":"CA209009-9-27_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"32.267","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"59","Sex":"M","Race":"WHITE","raw data file name":"0113_Marios_RCC_HP-000900027-2.raw"}
},
{
"Subject ID":"CA209009-9-30",
"Sample ID":"CA209009-9-30_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"12.167","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"F","Race":"WHITE","raw data file name":"0115_Marios_RCC_HP-000900030-2.raw"}
},
{
"Subject ID":"CA209009-9-34",
"Sample ID":"CA209009-9-34_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"31.900","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"61","Sex":"F","Race":"WHITE","raw data file name":"0118_Marios_RCC_HP-000900034-2.raw"}
},
{
"Subject ID":"CA209009-9-45",
"Sample ID":"CA209009-9-45_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"31.767","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"M","Race":"WHITE","raw data file name":"0121_Marios_RCC_HP-000900045-2.raw"}
},
{
"Subject ID":"CA209009-9-47",
"Sample ID":"CA209009-9-47_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"33.433","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"69","Sex":"M","Race":"WHITE","raw data file name":"0124_Marios_RCC_HP-000900047-2.raw"}
},
{
"Subject ID":"CA209009-9-66",
"Sample ID":"CA209009-9-66_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"15.667","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"47","Sex":"M","Race":"WHITE","raw data file name":"0129_Marios_RCC_HP-000900066-2.raw"}
},
{
"Subject ID":"CA209009-9-74",
"Sample ID":"CA209009-9-74_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"14.667","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"67","Sex":"M","Race":"WHITE","raw data file name":"0132_Marios_RCC_HP-000900074-2.raw"}
},
{
"Subject ID":"CA209009-9-88",
"Sample ID":"CA209009-9-88_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"29.267","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"63","Sex":"F","Race":"WHITE","raw data file name":"0135_Marios_RCC_HP-000900088-2.raw"}
},
{
"Subject ID":"CA209009-9-97",
"Sample ID":"CA209009-9-97_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"29.033","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"54","Sex":"M","Race":"WHITE","raw data file name":"0138_Marios_RCC_HP-000900097-2.raw"}
},
{
"Subject ID":"CA209009-9-119",
"Sample ID":"CA209009-9-119_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"25.767","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"72","Sex":"M","Race":"WHITE","raw data file name":"0141_Marios_RCC_HP-000900119-2.raw"}
},
{
"Subject ID":"CA209009-10-112",
"Sample ID":"CA209009-10-112_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"25.733","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"54","Sex":"M","Race":"OTHER","raw data file name":"0144_Marios_RCC_HP-001000112-2.raw"}
},
{
"Subject ID":"CA209009-11-5",
"Sample ID":"CA209009-11-5_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"16.400","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"63","Sex":"F","Race":"WHITE","raw data file name":"0147_Marios_RCC_HP-001100005-2.raw"}
},
{
"Subject ID":"CA209009-11-8",
"Sample ID":"CA209009-11-8_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"35.033","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"M","Race":"WHITE","raw data file name":"0150_Marios_RCC_HP-001100008-2.raw"}
},
{
"Subject ID":"CA209009-11-10",
"Sample ID":"CA209009-11-10_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
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},
{
"Subject ID":"CA209009-11-11",
"Sample ID":"CA209009-11-11_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
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},
{
"Subject ID":"CA209009-11-12",
"Sample ID":"CA209009-11-12_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"5.967","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"69","Sex":"F","Race":"WHITE","raw data file name":"0159_Marios_RCC_HP-001100012-2.raw"}
},
{
"Subject ID":"CA209009-11-13",
"Sample ID":"CA209009-11-13_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"36.467","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"F","Race":"WHITE","raw data file name":"0161_Marios_RCC_HP-001100013-2.raw"}
},
{
"Subject ID":"CA209009-11-14",
"Sample ID":"CA209009-11-14_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"34.167","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"59","Sex":"M","Race":"WHITE","raw data file name":"0164_Marios_RCC_HP-001100014-2.raw"}
},
{
"Subject ID":"CA209009-11-24",
"Sample ID":"CA209009-11-24_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"2.067","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"70","Sex":"M","Race":"WHITE","raw data file name":"0167_Marios_RCC_HP-001100024-2.raw"}
},
{
"Subject ID":"CA209009-11-25",
"Sample ID":"CA209009-11-25_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"5.567","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"72","Sex":"F","Race":"WHITE","raw data file name":"0169_Marios_RCC_HP-001100025-2.raw"}
},
{
"Subject ID":"CA209009-11-38",
"Sample ID":"CA209009-11-38_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"31.833","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"69","Sex":"M","Race":"WHITE","raw data file name":"0172_Marios_RCC_HP-001100038-2.raw"}
},
{
"Subject ID":"CA209009-11-40",
"Sample ID":"CA209009-11-40_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.467","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"32","Sex":"M","Race":"WHITE","raw data file name":"0175_Marios_RCC_HP-001100040-2.raw"}
},
{
"Subject ID":"CA209009-11-56",
"Sample ID":"CA209009-11-56_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"33.067","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"62","Sex":"F","Race":"WHITE","raw data file name":"0178_Marios_RCC_HP-001100056-2.raw"}
},
{
"Subject ID":"CA209009-11-57",
"Sample ID":"CA209009-11-57_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.300","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"48","Sex":"M","Race":"WHITE","raw data file name":"0181_Marios_RCC_HP-001100057-2.raw"}
},
{
"Subject ID":"CA209009-11-71",
"Sample ID":"CA209009-11-71_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"31.800","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"57","Sex":"M","Race":"WHITE","raw data file name":"0184_Marios_RCC_HP-001100071-2.raw"}
},
{
"Subject ID":"CA209009-11-79",
"Sample ID":"CA209009-11-79_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"29.100","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"61","Sex":"F","Race":"WHITE","raw data file name":"0187_Marios_RCC_HP-001100079-2.raw"}
},
{
"Subject ID":"CA209009-11-93",
"Sample ID":"CA209009-11-93_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"22.800","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"M","Race":"WHITE","raw data file name":"0190_Marios_RCC_HP-001100093-2.raw"}
},
{
"Subject ID":"CA209009-12-115",
"Sample ID":"CA209009-12-115_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"12.200","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"M","Race":"WHITE","raw data file name":"0192_Marios_RCC_HP-001200115-2.raw"}
},
{
"Subject ID":"CA209009-13-51",
"Sample ID":"CA209009-13-51_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.233","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"45","Sex":"M","Race":"WHITE","raw data file name":"0196_Marios_RCC_HP-001300051-2.raw"}
},
{
"Subject ID":"CA209009-13-90",
"Sample ID":"CA209009-13-90_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"16.633","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"54","Sex":"M","Race":"OTHER","raw data file name":"0199_Marios_RCC_HP-001300090-2.raw"}
},
{
"Subject ID":"CA209009-13-96",
"Sample ID":"CA209009-13-96_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"19.400","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"75","Sex":"F","Race":"WHITE","raw data file name":"0202_Marios_RCC_HP-001300096-2.raw"}
},
{
"Subject ID":"CA209009-13-103",
"Sample ID":"CA209009-13-103_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"28.733","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"51","Sex":"M","Race":"OTHER","raw data file name":"0205_Marios_RCC_HP-001300103-2.raw"}
},
{
"Subject ID":"CA209009-13-111",
"Sample ID":"CA209009-13-111_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"27.800","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"68","Sex":"M","Race":"WHITE","raw data file name":"0208_Marios_RCC_HP-001300111-2.raw"}
},
{
"Subject ID":"CA209009-14-59",
"Sample ID":"CA209009-14-59_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"33.033","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"64","Sex":"M","Race":"WHITE","raw data file name":"0211_Marios_RCC_HP-001400059-2.raw"}
},
{
"Subject ID":"CA209009-14-69",
"Sample ID":"CA209009-14-69_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"10.100","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"40","Sex":"F","Race":"WHITE","raw data file name":"0214_Marios_RCC_HP-001400069-2.raw"}
},
{
"Subject ID":"CA209009-14-80",
"Sample ID":"CA209009-14-80_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"4.900","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"61","Sex":"M","Race":"WHITE","raw data file name":"0216_Marios_RCC_HP-001400080-2.raw"}
},
{
"Subject ID":"CA209009-14-87",
"Sample ID":"CA209009-14-87_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"11.667","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"62","Sex":"F","Race":"WHITE","raw data file name":"0219_Marios_RCC_HP-001400087-2.raw"}
},
{
"Subject ID":"CA209009-14-89",
"Sample ID":"CA209009-14-89_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"9.767","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"78","Sex":"M","Race":"WHITE","raw data file name":"0222_Marios_RCC_HP-001400089-2.raw"}
},
{
"Subject ID":"CA209009-14-98",
"Sample ID":"CA209009-14-98_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"13.267","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"65","Sex":"M","Race":"WHITE","raw data file name":"0225_Marios_RCC_HP-001400098-2.raw"}
},
{
"Subject ID":"CA209009-14-107",
"Sample ID":"CA209009-14-107_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"27.233","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"82","Sex":"M","Race":"WHITE","raw data file name":"0228_Marios_RCC_HP-001400107-2.raw"}
},
{
"Subject ID":"CA209009-15-75",
"Sample ID":"CA209009-15-75_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"27.367","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"70","Sex":"F","Race":"WHITE","raw data file name":"0231_Marios_RCC_HP-001500075-2.raw"}
},
{
"Subject ID":"CA209009-15-76",
"Sample ID":"CA209009-15-76_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"22.067","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"42","Sex":"M","Race":"WHITE","raw data file name":"0234_Marios_RCC_HP-001500076-2.raw"}
},
{
"Subject ID":"CA209009-15-77",
"Sample ID":"CA209009-15-77_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"4.400","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"50","Sex":"M","Race":"WHITE","raw data file name":"0237_Marios_RCC_HP-001500077-2.raw"}
},
{
"Subject ID":"CA209009-15-81",
"Sample ID":"CA209009-15-81_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"30.400","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"45","Sex":"F","Race":"WHITE","raw data file name":"0239_Marios_RCC_HP-001500081-2.raw"}
},
{
"Subject ID":"CA209009-15-83",
"Sample ID":"CA209009-15-83_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"16.200","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"46","Sex":"M","Race":"WHITE","raw data file name":"0242_Marios_RCC_HP-001500083-2.raw"}
},
{
"Subject ID":"CA209009-15-94",
"Sample ID":"CA209009-15-94_week 4",
"Factors":{"Time point":"week 4","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"30.400","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"41","Sex":"F","Race":"WHITE","raw data file name":"0244_Marios_RCC_HP-001500094-2.raw"}
},
{
"Subject ID":"CA209009-1-20",
"Sample ID":"CA209009-1-20_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"35.500","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"76","Sex":"M","Race":"WHITE","raw data file name":"0003_Marios_RCC_HP-000100020-3.raw"}
},
{
"Subject ID":"CA209009-1-32",
"Sample ID":"CA209009-1-32_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"8.000","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"65","Sex":"M","Race":"WHITE","raw data file name":"0006_Marios_RCC_HP-000100032-3.raw"}
},
{
"Subject ID":"CA209009-1-43",
"Sample ID":"CA209009-1-43_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.267","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"74","Sex":"M","Race":"WHITE","raw data file name":"0009_Marios_RCC_HP-000100043-3.raw"}
},
{
"Subject ID":"CA209009-1-62",
"Sample ID":"CA209009-1-62_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"3.533","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"48","Sex":"F","Race":"WHITE","raw data file name":"0012_Marios_RCC_HP-000100062-3.raw"}
},
{
"Subject ID":"CA209009-1-72",
"Sample ID":"CA209009-1-72_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"9.433","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"58","Sex":"M","Race":"WHITE","raw data file name":"0015_Marios_RCC_HP-000100072-3.raw"}
},
{
"Subject ID":"CA209009-1-86",
"Sample ID":"CA209009-1-86_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"15.467","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"71","Sex":"M","Race":"WHITE","raw data file name":"0018_Marios_RCC_HP-000100086-3.raw"}
},
{
"Subject ID":"CA209009-1-118",
"Sample ID":"CA209009-1-118_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"5.900","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"82","Sex":"M","Race":"WHITE","raw data file name":"0021_Marios_RCC_HP-000100118-3.raw"}
},
{
"Subject ID":"CA209009-2-48",
"Sample ID":"CA209009-2-48_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"32.767","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"62","Sex":"M","Race":"WHITE","raw data file name":"0025_Marios_RCC_HP-000200048-3.raw"}
},
{
"Subject ID":"CA209009-2-58",
"Sample ID":"CA209009-2-58_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"32.933","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"55","Sex":"F","Race":"OTHER","raw data file name":"0028_Marios_RCC_HP-000200058-3.raw"}
},
{
"Subject ID":"CA209009-2-64",
"Sample ID":"CA209009-2-64_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"25.533","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"59","Sex":"M","Race":"WHITE","raw data file name":"0031_Marios_RCC_HP-000200064-3.raw"}
},
{
"Subject ID":"CA209009-2-84",
"Sample ID":"CA209009-2-84_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"22.667","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"55","Sex":"F","Race":"OTHER","raw data file name":"0034_Marios_RCC_HP-000200084-3.raw"}
},
{
"Subject ID":"CA209009-3-15",
"Sample ID":"CA209009-3-15_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"33.767","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"73","Sex":"F","Race":"WHITE","raw data file name":"0041_Marios_RCC_HP-000300015-3.raw"}
},
{
"Subject ID":"CA209009-3-114",
"Sample ID":"CA209009-3-114_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"11.333","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"57","Sex":"F","Race":"WHITE","raw data file name":"0045_Marios_RCC_HP-000300114-3.raw"}
},
{
"Subject ID":"CA209009-3-117",
"Sample ID":"CA209009-3-117_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"2.133","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"58","Sex":"M","Race":"WHITE","raw data file name":"0048_Marios_RCC_HP-000300117-3.raw"}
},
{
"Subject ID":"CA209009-4-49",
"Sample ID":"CA209009-4-49_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
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},
{
"Subject ID":"CA209009-4-54",
"Sample ID":"CA209009-4-54_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"32.533","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"65","Sex":"F","Race":"WHITE","raw data file name":"0055_Marios_RCC_HP-000400054-3.raw"}
},
{
"Subject ID":"CA209009-5-4",
"Sample ID":"CA209009-5-4_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
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},
{
"Subject ID":"CA209009-5-6",
"Sample ID":"CA209009-5-6_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"5.167","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"59","Sex":"F","Race":"WHITE","raw data file name":"0070_Marios_RCC_HP-000500006-3.raw"}
},
{
"Subject ID":"CA209009-5-17",
"Sample ID":"CA209009-5-17_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"5.633","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"55","Sex":"M","Race":"WHITE","raw data file name":"0073_Marios_RCC_HP-000500017-3.raw"}
},
{
"Subject ID":"CA209009-5-18",
"Sample ID":"CA209009-5-18_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"3.700","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"68","Sex":"M","Race":"WHITE","raw data file name":"0076_Marios_RCC_HP-000500018-3.raw"}
},
{
"Subject ID":"CA209009-5-22",
"Sample ID":"CA209009-5-22_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"6.567","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"63","Sex":"M","Race":"WHITE","raw data file name":"0081_Marios_RCC_HP-000500022-3.raw"}
},
{
"Subject ID":"CA209009-5-23",
"Sample ID":"CA209009-5-23_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"4.967","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"66","Sex":"M","Race":"WHITE","raw data file name":"0084_Marios_RCC_HP-000500023-3.raw"}
},
{
"Subject ID":"CA209009-5-29",
"Sample ID":"CA209009-5-29_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"31.233","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"67","Sex":"M","Race":"WHITE","raw data file name":"0089_Marios_RCC_HP-000500029-3.raw"}
},
{
"Subject ID":"CA209009-5-41",
"Sample ID":"CA209009-5-41_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"6.500","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"66","Sex":"M","Race":"WHITE","raw data file name":"0092_Marios_RCC_HP-000500041-3.raw"}
},
{
"Subject ID":"CA209009-5-50",
"Sample ID":"CA209009-5-50_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.733","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"63","Sex":"F","Race":"WHITE","raw data file name":"0095_Marios_RCC_HP-000500050-3.raw"}
},
{
"Subject ID":"CA209009-5-73",
"Sample ID":"CA209009-5-73_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"5.933","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"77","Sex":"M","Race":"WHITE","raw data file name":"0099_Marios_RCC_HP-000500073-3.raw"}
},
{
"Subject ID":"CA209009-5-106",
"Sample ID":"CA209009-5-106_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"29.000","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"61","Sex":"F","Race":"WHITE","raw data file name":"0102_Marios_RCC_HP-000500106-3.raw"}
},
{
"Subject ID":"CA209009-6-39",
"Sample ID":"CA209009-6-39_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"10.200","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"72","Sex":"M","Race":"WHITE","raw data file name":"0105_Marios_RCC_HP-000600039-3.raw"}
},
{
"Subject ID":"CA209009-8-100",
"Sample ID":"CA209009-8-100_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"26.600","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"58","Sex":"F","Race":"WHITE","raw data file name":"0109_Marios_RCC_HP-000800100-3.raw"}
},
{
"Subject ID":"CA209009-9-30",
"Sample ID":"CA209009-9-30_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"12.167","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"F","Race":"WHITE","raw data file name":"0116_Marios_RCC_HP-000900030-3.raw"}
},
{
"Subject ID":"CA209009-9-34",
"Sample ID":"CA209009-9-34_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"31.900","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"61","Sex":"F","Race":"WHITE","raw data file name":"0119_Marios_RCC_HP-000900034-3.raw"}
},
{
"Subject ID":"CA209009-9-45",
"Sample ID":"CA209009-9-45_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"31.767","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"M","Race":"WHITE","raw data file name":"0122_Marios_RCC_HP-000900045-3.raw"}
},
{
"Subject ID":"CA209009-9-47",
"Sample ID":"CA209009-9-47_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"33.433","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"69","Sex":"M","Race":"WHITE","raw data file name":"0125_Marios_RCC_HP-000900047-3.raw"}
},
{
"Subject ID":"CA209009-9-52",
"Sample ID":"CA209009-9-52_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
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},
{
"Subject ID":"CA209009-9-66",
"Sample ID":"CA209009-9-66_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"15.667","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"47","Sex":"M","Race":"WHITE","raw data file name":"0130_Marios_RCC_HP-000900066-3.raw"}
},
{
"Subject ID":"CA209009-9-74",
"Sample ID":"CA209009-9-74_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"14.667","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"67","Sex":"M","Race":"WHITE","raw data file name":"0133_Marios_RCC_HP-000900074-3.raw"}
},
{
"Subject ID":"CA209009-9-88",
"Sample ID":"CA209009-9-88_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
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},
{
"Subject ID":"CA209009-9-97",
"Sample ID":"CA209009-9-97_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"29.033","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"54","Sex":"M","Race":"WHITE","raw data file name":"0139_Marios_RCC_HP-000900097-3.raw"}
},
{
"Subject ID":"CA209009-9-119",
"Sample ID":"CA209009-9-119_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"25.767","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"72","Sex":"M","Race":"WHITE","raw data file name":"0142_Marios_RCC_HP-000900119-3.raw"}
},
{
"Subject ID":"CA209009-10-112",
"Sample ID":"CA209009-10-112_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"25.733","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"54","Sex":"M","Race":"OTHER","raw data file name":"0145_Marios_RCC_HP-001000112-3.raw"}
},
{
"Subject ID":"CA209009-11-5",
"Sample ID":"CA209009-11-5_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"16.400","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"63","Sex":"F","Race":"WHITE","raw data file name":"0148_Marios_RCC_HP-001100005-3.raw"}
},
{
"Subject ID":"CA209009-11-8",
"Sample ID":"CA209009-11-8_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"35.033","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"M","Race":"WHITE","raw data file name":"0151_Marios_RCC_HP-001100008-3.raw"}
},
{
"Subject ID":"CA209009-11-10",
"Sample ID":"CA209009-11-10_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"35.267","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"F","Race":"WHITE","raw data file name":"0154_Marios_RCC_HP-001100010-3.raw"}
},
{
"Subject ID":"CA209009-11-11",
"Sample ID":"CA209009-11-11_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"34.133","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"50","Sex":"M","Race":"WHITE","raw data file name":"0157_Marios_RCC_HP-001100011-3.raw"}
},
{
"Subject ID":"CA209009-11-13",
"Sample ID":"CA209009-11-13_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"36.467","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"64","Sex":"F","Race":"WHITE","raw data file name":"0162_Marios_RCC_HP-001100013-3.raw"}
},
{
"Subject ID":"CA209009-11-14",
"Sample ID":"CA209009-11-14_week 9",
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},
{
"Subject ID":"CA209009-11-25",
"Sample ID":"CA209009-11-25_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"5.567","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"72","Sex":"F","Race":"WHITE","raw data file name":"0170_Marios_RCC_HP-001100025-3.raw"}
},
{
"Subject ID":"CA209009-11-38",
"Sample ID":"CA209009-11-38_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"31.833","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"69","Sex":"M","Race":"WHITE","raw data file name":"0173_Marios_RCC_HP-001100038-3.raw"}
},
{
"Subject ID":"CA209009-11-40",
"Sample ID":"CA209009-11-40_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.467","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"32","Sex":"M","Race":"WHITE","raw data file name":"0176_Marios_RCC_HP-001100040-3.raw"}
},
{
"Subject ID":"CA209009-11-56",
"Sample ID":"CA209009-11-56_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"33.067","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"62","Sex":"F","Race":"WHITE","raw data file name":"0179_Marios_RCC_HP-001100056-3.raw"}
},
{
"Subject ID":"CA209009-11-57",
"Sample ID":"CA209009-11-57_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.300","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"48","Sex":"M","Race":"WHITE","raw data file name":"0182_Marios_RCC_HP-001100057-3.raw"}
},
{
"Subject ID":"CA209009-11-71",
"Sample ID":"CA209009-11-71_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"31.800","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"57","Sex":"M","Race":"WHITE","raw data file name":"0185_Marios_RCC_HP-001100071-3.raw"}
},
{
"Subject ID":"CA209009-11-79",
"Sample ID":"CA209009-11-79_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"29.100","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"61","Sex":"F","Race":"WHITE","raw data file name":"0188_Marios_RCC_HP-001100079-3.raw"}
},
{
"Subject ID":"CA209009-12-115",
"Sample ID":"CA209009-12-115_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"12.200","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"60","Sex":"M","Race":"WHITE","raw data file name":"0193_Marios_RCC_HP-001200115-3.raw"}
},
{
"Subject ID":"CA209009-13-51",
"Sample ID":"CA209009-13-51_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"32.233","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"45","Sex":"M","Race":"WHITE","raw data file name":"0197_Marios_RCC_HP-001300051-3.raw"}
},
{
"Subject ID":"CA209009-13-90",
"Sample ID":"CA209009-13-90_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"16.633","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"54","Sex":"M","Race":"OTHER","raw data file name":"0200_Marios_RCC_HP-001300090-3.raw"}
},
{
"Subject ID":"CA209009-13-96",
"Sample ID":"CA209009-13-96_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"19.400","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"75","Sex":"F","Race":"WHITE","raw data file name":"0203_Marios_RCC_HP-001300096-3.raw"}
},
{
"Subject ID":"CA209009-13-103",
"Sample ID":"CA209009-13-103_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"28.733","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"51","Sex":"M","Race":"OTHER","raw data file name":"0206_Marios_RCC_HP-001300103-3.raw"}
},
{
"Subject ID":"CA209009-13-111",
"Sample ID":"CA209009-13-111_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"27.800","Trial":"Phase I_RCC_CA209009","Region":"USA","Derived_Age_at_Consent":"68","Sex":"M","Race":"WHITE","raw data file name":"0209_Marios_RCC_HP-001300111-3.raw"}
},
{
"Subject ID":"CA209009-14-59",
"Sample ID":"CA209009-14-59_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"33.033","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"64","Sex":"M","Race":"WHITE","raw data file name":"0212_Marios_RCC_HP-001400059-3.raw"}
},
{
"Subject ID":"CA209009-14-80",
"Sample ID":"CA209009-14-80_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"4.900","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"61","Sex":"M","Race":"WHITE","raw data file name":"0217_Marios_RCC_HP-001400080-3.raw"}
},
{
"Subject ID":"CA209009-14-87",
"Sample ID":"CA209009-14-87_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"11.667","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"62","Sex":"F","Race":"WHITE","raw data file name":"0220_Marios_RCC_HP-001400087-3.raw"}
},
{
"Subject ID":"CA209009-14-89",
"Sample ID":"CA209009-14-89_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"9.767","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"78","Sex":"M","Race":"WHITE","raw data file name":"0223_Marios_RCC_HP-001400089-3.raw"}
},
{
"Subject ID":"CA209009-14-98",
"Sample ID":"CA209009-14-98_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"0.3"},
"Additional sample data":{"OS (Overall Survival, months)":"13.267","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"65","Sex":"M","Race":"WHITE","raw data file name":"0226_Marios_RCC_HP-001400098-3.raw"}
},
{
"Subject ID":"CA209009-14-107",
"Sample ID":"CA209009-14-107_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"27.233","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"82","Sex":"M","Race":"WHITE","raw data file name":"0229_Marios_RCC_HP-001400107-3.raw"}
},
{
"Subject ID":"CA209009-15-75",
"Sample ID":"CA209009-15-75_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"2"},
"Additional sample data":{"OS (Overall Survival, months)":"27.367","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"70","Sex":"F","Race":"WHITE","raw data file name":"0232_Marios_RCC_HP-001500075-3.raw"}
},
{
"Subject ID":"CA209009-15-76",
"Sample ID":"CA209009-15-76_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"-","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"22.067","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"42","Sex":"M","Race":"WHITE","raw data file name":"0235_Marios_RCC_HP-001500076-3.raw"}
},
{
"Subject ID":"CA209009-15-81",
"Sample ID":"CA209009-15-81_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"30.400","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"45","Sex":"F","Race":"WHITE","raw data file name":"0240_Marios_RCC_HP-001500081-3.raw"}
},
{
"Subject ID":"CA209009-15-94",
"Sample ID":"CA209009-15-94_week 9",
"Factors":{"Time point":"week 9","OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS)":"1","Nivolumab Dose (mg/kg)":"10"},
"Additional sample data":{"OS (Overall Survival, months)":"30.400","Trial":"Phase I_RCC_CA209009","Region":"OTHER","Derived_Age_at_Consent":"41","Sex":"F","Race":"WHITE","raw data file name":"0245_Marios_RCC_HP-001500094-3.raw"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Serum was collected at the specified time-points by centrifugation at 4000g for 4 minutes at 25°C within 2 hours of collection. Samples were frozen immediately and stored at or below -20°C for up to two months followed by storage at -80°C.","SAMPLE_TYPE":"Blood (serum)","STORAGE_CONDITIONS":"Described in summary"},

"TREATMENT":{"TREATMENT_SUMMARY":"In CA209-009, NCT01358721, Nivolumab was administered intravenously every 3 weeks at 0.3, 2, or 10 mg/kg to previously treated patients and 10 mg/kg to treatment-naïve patients with metastatic renal cell carcinoma (mRCC).","TREATMENT_PROTOCOL_ID":"NCT01358721"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Serum samples (10 µL) were extracted using 90 µL of 74.9:24.9:0.2 (v/v/v) acetonitrile/methanol/formic acid containing stable isotope-labeled internal standards (0.2 ng/µL valine-d8, Isotec; 0.2 ng/µL phenylalanine-d8, Cambridge Isotope Laboratories). The samples were centrifuged (10 min, 9000g, 4ºC) and the supernatants were transferred to autosampler vials with de-activated inserts (Waters)."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Extracts (10 µL) were injected onto a 150 x 2.1 mm Atlantis HILIC column (Waters). The column was eluted isocratically at a flow rate of 250 µL/min with 5% mobile phase A (10 mM ammonium formate and 0.1% formic acid in water) for 1 minute followed by a linear gradient to 40% mobile phase B (acetonitrile with 0.1% formic acid) over 10 minutes","CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Shimadzu Nexera X2","COLUMN_NAME":"Waters Atlantis HILIC (150 x 2.1 mm)","FLOW_RATE":"250 µL/min","COLUMN_TEMPERATURE":"30","SOLVENT_A":"10 mM ammonium formate and 0.1% formic acid in water","SOLVENT_B":"acetonitrile with 0.1% formic acid"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"High resolution, accurate mass data were acquired using a system comprised of a Shimadzu Nexera X2 U-HPLC (Shimadzu Corp.; Marlborough, MA) coupled to a Q Exactive hybrid quadrupole orbitrap mass spectrometer (Thermo Fisher Scientific; Waltham, MA). MS analyses were carried out using electrospray ionization in the positive ion mode using full scan analysis over 70-800 m/z at 70,000 resolution and 3 Hz data acquisition rate. Other MS settings were: sheath gas 40, sweep gas 2, spray voltage 3.5 kV, capillary temperature 350°C, S-lens RF 40, heater temperature 300°C, microscans 1, automatic gain control target 1e6, and maximum ion time 250 ms. Raw data were processed using TraceFinder software (Thermo Fisher Scientific; Waltham, MA) and Progenesis QI (Nonlinear Dynamics; Newcastle upon Tyne, UK). The identities of 202 profiled metabolites were confirmed using reference standards."},

"MS_METABOLITE_DATA":{
"Units":"Log10(Peak Area)",

"Data":[{"Metabolite":"Kynurenine_μM","CA209009-1-20_baseline":"6.764","CA209009-1-32_baseline":"6.734","CA209009-1-43_baseline":"5.879","CA209009-1-62_baseline":"9.095","CA209009-1-72_baseline":"4.534","CA209009-1-86_baseline":"4.909","CA209009-1-118_baseline":"7.453","CA209009-2-42_baseline":"6.916","CA209009-2-48_baseline":"5.974","CA209009-2-58_baseline":"5.441","CA209009-2-64_baseline":"6.403","CA209009-2-84_baseline":"6.093","CA209009-2-85_baseline":"4.668","CA209009-2-102_baseline":"10.196","CA209009-3-15_baseline":"5.959","CA209009-3-26_baseline":"5.440","CA209009-3-114_baseline":"10.674","CA209009-3-117_baseline":"7.228","CA209009-4-49_baseline":"7.130","CA209009-4-54_baseline":"6.693","CA209009-4-68_baseline":"6.548","CA209009-4-95_baseline":"4.811","CA209009-5-1_baseline":"4.543","CA209009-5-2_baseline":"6.805","CA209009-5-3_baseline":"2.689","CA209009-5-4_baseline":"7.585","CA209009-5-6_baseline":"5.835","CA209009-5-17_baseline":"7.218","CA209009-5-18_baseline":"5.635","CA209009-5-21_baseline":"5.235","CA209009-5-22_baseline":"5.185","CA209009-5-23_baseline":"5.802","CA209009-5-28_baseline":"19.117","CA209009-5-29_baseline":"9.608","CA209009-5-41_baseline":"5.656","CA209009-5-50_baseline":"5.698","CA209009-5-63_baseline":"6.269","CA209009-5-73_baseline":"5.591","CA209009-5-106_baseline":"7.817","CA209009-6-39_baseline":"4.581","CA209009-6-99_baseline":"7.374","CA209009-8-100_baseline":"9.326","CA209009-8-105_baseline":"6.591","CA209009-9-27_baseline":"7.068","CA209009-9-30_baseline":"5.054","CA209009-9-34_baseline":"10.223","CA209009-9-45_baseline":"7.965","CA209009-9-47_baseline":"7.947","CA209009-9-52_baseline":"5.564","CA209009-9-66_baseline":"5.176","CA209009-9-74_baseline":"4.881","CA209009-9-88_baseline":"7.989","CA209009-9-97_baseline":"5.536","CA209009-9-119_baseline":"8.662","CA209009-10-112_baseline":"4.906","CA209009-11-5_baseline":"4.702","CA209009-11-8_baseline":"5.792","CA209009-11-10_baseline":"8.768","CA209009-11-11_baseline":"6.087","CA209009-11-12_baseline":"8.356","CA209009-11-13_baseline":"7.274","CA209009-11-14_baseline":"5.501","CA209009-11-24_baseline":"5.325","CA209009-11-25_baseline":"8.123","CA209009-11-38_baseline":"4.950","CA209009-11-40_baseline":"5.103","CA209009-11-56_baseline":"7.316","CA209009-11-57_baseline":"4.970","CA209009-11-71_baseline":"6.541","CA209009-11-79_baseline":"5.194","CA209009-11-93_baseline":"4.660","CA209009-12-115_baseline":"4.375","CA209009-13-36_baseline":"7.889","CA209009-13-51_baseline":"8.128","CA209009-13-90_baseline":"4.430","CA209009-13-96_baseline":"7.488","CA209009-13-103_baseline":"4.881","CA209009-13-111_baseline":"6.623","CA209009-14-59_baseline":"5.724","CA209009-14-69_baseline":"5.904","CA209009-14-80_baseline":"7.032","CA209009-14-87_baseline":"6.800","CA209009-14-89_baseline":"9.424","CA209009-14-98_baseline":"7.477","CA209009-14-107_baseline":"5.491","CA209009-15-75_baseline":"4.301","CA209009-15-76_baseline":"8.305","CA209009-15-77_baseline":"7.112","CA209009-15-81_baseline":"8.889","CA209009-15-83_baseline":"9.970","CA209009-15-94_baseline":"4.908","CA209009-1-20_week 4":"8.354","CA209009-1-32_week 4":"8.874","CA209009-1-43_week 4":"5.365","CA209009-1-62_week 4":"7.525","CA209009-1-72_week 4":"3.812","CA209009-1-86_week 4":"5.517","CA209009-1-118_week 4":"10.322","CA209009-2-48_week 4":"8.651","CA209009-2-58_week 4":"5.847","CA209009-2-64_week 4":"7.052","CA209009-2-84_week 4":"8.311","CA209009-2-85_week 4":"5.523","CA209009-2-102_week 4":"10.318","CA209009-3-15_week 4":"6.419","CA209009-3-114_week 4":"10.503","CA209009-3-117_week 4":"8.130","CA209009-4-49_week 4":"7.898","CA209009-4-54_week 4":"6.414","CA209009-4-68_week 4":"7.380","CA209009-4-95_week 4":"6.280","CA209009-5-1_week 4":"5.996","CA209009-5-3_week 4":"2.904","CA209009-5-4_week 4":"10.134","CA209009-5-6_week 4":"4.912","CA209009-5-17_week 4":"7.979","CA209009-5-18_week 4":"7.859","CA209009-5-21_week 4":"8.224","CA209009-5-22_week 4":"6.007","CA209009-5-23_week 4":"7.549","CA209009-5-28_week 4":"13.200","CA209009-5-29_week 4":"13.152","CA209009-5-41_week 4":"6.495","CA209009-5-50_week 4":"5.189","CA209009-5-73_week 4":"7.044","CA209009-5-106_week 4":"9.678","CA209009-6-39_week 4":"5.062","CA209009-8-100_week 4":"12.021","CA209009-8-105_week 4":"10.570","CA209009-9-27_week 4":"6.083","CA209009-9-30_week 4":"6.671","CA209009-9-34_week 4":"7.207","CA209009-9-45_week 4":"17.247","CA209009-9-47_week 4":"7.357","CA209009-9-66_week 4":"6.508","CA209009-9-74_week 4":"8.617","CA209009-9-88_week 4":"9.602","CA209009-9-97_week 4":"5.980","CA209009-9-119_week 4":"14.753","CA209009-10-112_week 4":"5.193","CA209009-11-5_week 4":"7.045","CA209009-11-8_week 4":"7.944","CA209009-11-10_week 4":"9.850","CA209009-11-11_week 4":"7.605","CA209009-11-12_week 4":"9.973","CA209009-11-13_week 4":"6.814","CA209009-11-14_week 4":"6.032","CA209009-11-24_week 4":"4.770","CA209009-11-25_week 4":"7.081","CA209009-11-38_week 4":"5.612","CA209009-11-40_week 4":"6.695","CA209009-11-56_week 4":"10.709","CA209009-11-57_week 4":"5.283","CA209009-11-71_week 4":"5.595","CA209009-11-79_week 4":"4.923","CA209009-11-93_week 4":"6.937","CA209009-12-115_week 4":"5.558","CA209009-13-51_week 4":"7.515","CA209009-13-90_week 4":"4.895","CA209009-13-96_week 4":"14.118","CA209009-13-103_week 4":"4.392","CA209009-13-111_week 4":"8.320","CA209009-14-59_week 4":"5.942","CA209009-14-69_week 4":"6.737","CA209009-14-80_week 4":"8.221","CA209009-14-87_week 4":"6.469","CA209009-14-89_week 4":"8.592","CA209009-14-98_week 4":"10.590","CA209009-14-107_week 4":"6.183","CA209009-15-75_week 4":"5.534","CA209009-15-76_week 4":"6.698","CA209009-15-77_week 4":"7.415","CA209009-15-81_week 4":"12.650","CA209009-15-83_week 4":"14.364","CA209009-15-94_week 4":"7.176","CA209009-1-20_week 9":"8.568","CA209009-1-32_week 9":"10.015","CA209009-1-43_week 9":"7.362","CA209009-1-62_week 9":"8.936","CA209009-1-72_week 9":"3.327","CA209009-1-86_week 9":"6.142","CA209009-1-118_week 9":"8.519","CA209009-2-48_week 9":"8.114","CA209009-2-58_week 9":"7.024","CA209009-2-64_week 9":"6.041","CA209009-2-84_week 9":"6.319","CA209009-3-15_week 9":"7.535","CA209009-3-114_week 9":"10.943","CA209009-3-117_week 9":"8.471","CA209009-4-49_week 9":"7.809","CA209009-4-54_week 9":"14.543","CA209009-5-4_week 9":"9.020","CA209009-5-6_week 9":"5.338","CA209009-5-17_week 9":"9.792","CA209009-5-18_week 9":"5.791","CA209009-5-22_week 9":"6.755","CA209009-5-23_week 9":"5.340","CA209009-5-29_week 9":"12.762","CA209009-5-41_week 9":"7.364","CA209009-5-50_week 9":"5.346","CA209009-5-73_week 9":"7.401","CA209009-5-106_week 9":"5.220","CA209009-6-39_week 9":"4.013","CA209009-8-100_week 9":"11.572","CA209009-9-30_week 9":"6.980","CA209009-9-34_week 9":"8.028","CA209009-9-45_week 9":"12.493","CA209009-9-47_week 9":"8.635","CA209009-9-52_week 9":"5.822","CA209009-9-66_week 9":"5.286","CA209009-9-74_week 9":"11.498","CA209009-9-88_week 9":"11.790","CA209009-9-97_week 9":"6.050","CA209009-9-119_week 9":"7.091","CA209009-10-112_week 9":"4.074","CA209009-11-5_week 9":"6.666","CA209009-11-8_week 9":"6.925","CA209009-11-10_week 9":"11.181","CA209009-11-11_week 9":"6.730","CA209009-11-13_week 9":"8.321","CA209009-11-14_week 9":"5.790","CA209009-11-25_week 9":"7.474","CA209009-11-38_week 9":"4.839","CA209009-11-40_week 9":"7.900","CA209009-11-56_week 9":"8.723","CA209009-11-57_week 9":"5.661","CA209009-11-71_week 9":"5.896","CA209009-11-79_week 9":"5.657","CA209009-12-115_week 9":"7.258","CA209009-13-51_week 9":"7.142","CA209009-13-90_week 9":"5.042","CA209009-13-96_week 9":"14.425","CA209009-13-103_week 9":"5.343","CA209009-13-111_week 9":"7.605","CA209009-14-59_week 9":"7.609","CA209009-14-80_week 9":"10.820","CA209009-14-87_week 9":"6.199","CA209009-14-89_week 9":"9.721","CA209009-14-98_week 9":"14.664","CA209009-14-107_week 9":"5.797","CA209009-15-75_week 9":"6.174","CA209009-15-76_week 9":"6.815","CA209009-15-81_week 9":"9.975","CA209009-15-94_week 9":"6.640"},{"Metabolite":"Tryptophan_μM","CA209009-1-20_baseline":"44.180","CA209009-1-32_baseline":"65.961","CA209009-1-43_baseline":"42.147","CA209009-1-62_baseline":"60.429","CA209009-1-72_baseline":"14.752","CA209009-1-86_baseline":"22.129","CA209009-1-118_baseline":"27.481","CA209009-2-42_baseline":"56.540","CA209009-2-48_baseline":"42.197","CA209009-2-58_baseline":"39.490","CA209009-2-64_baseline":"46.187","CA209009-2-84_baseline":"34.989","CA209009-2-85_baseline":"34.869","CA209009-2-102_baseline":"60.495","CA209009-3-15_baseline":"49.437","CA209009-3-26_baseline":"37.784","CA209009-3-114_baseline":"57.094","CA209009-3-117_baseline":"57.574","CA209009-4-49_baseline":"59.551","CA209009-4-54_baseline":"30.871","CA209009-4-68_baseline":"61.452","CA209009-4-95_baseline":"37.873","CA209009-5-1_baseline":"25.902","CA209009-5-2_baseline":"49.103","CA209009-5-3_baseline":"20.986","CA209009-5-4_baseline":"47.163","CA209009-5-6_baseline":"46.541","CA209009-5-17_baseline":"29.510","CA209009-5-18_baseline":"47.445","CA209009-5-21_baseline":"40.393","CA209009-5-22_baseline":"21.771","CA209009-5-23_baseline":"43.253","CA209009-5-28_baseline":"57.224","CA209009-5-29_baseline":"32.090","CA209009-5-41_baseline":"38.761","CA209009-5-50_baseline":"47.718","CA209009-5-63_baseline":"27.643","CA209009-5-73_baseline":"35.403","CA209009-5-106_baseline":"62.604","CA209009-6-39_baseline":"29.512","CA209009-6-99_baseline":"26.750","CA209009-8-100_baseline":"38.543","CA209009-8-105_baseline":"41.961","CA209009-9-27_baseline":"46.678","CA209009-9-30_baseline":"39.678","CA209009-9-34_baseline":"80.800","CA209009-9-45_baseline":"31.266","CA209009-9-47_baseline":"53.588","CA209009-9-52_baseline":"47.219","CA209009-9-66_baseline":"54.416","CA209009-9-74_baseline":"16.873","CA209009-9-88_baseline":"17.200","CA209009-9-97_baseline":"49.542","CA209009-9-119_baseline":"42.643","CA209009-10-112_baseline":"44.994","CA209009-11-5_baseline":"37.178","CA209009-11-8_baseline":"26.537","CA209009-11-10_baseline":"63.963","CA209009-11-11_baseline":"62.823","CA209009-11-12_baseline":"50.833","CA209009-11-13_baseline":"32.273","CA209009-11-14_baseline":"50.013","CA209009-11-24_baseline":"39.396","CA209009-11-25_baseline":"44.577","CA209009-11-38_baseline":"49.660","CA209009-11-40_baseline":"48.490","CA209009-11-56_baseline":"43.138","CA209009-11-57_baseline":"70.041","CA209009-11-71_baseline":"66.173","CA209009-11-79_baseline":"63.094","CA209009-11-93_baseline":"33.617","CA209009-12-115_baseline":"27.870","CA209009-13-36_baseline":"26.519","CA209009-13-51_baseline":"61.872","CA209009-13-90_baseline":"47.766","CA209009-13-96_baseline":"25.918","CA209009-13-103_baseline":"49.802","CA209009-13-111_baseline":"41.253","CA209009-14-59_baseline":"74.941","CA209009-14-69_baseline":"42.055","CA209009-14-80_baseline":"59.911","CA209009-14-87_baseline":"38.462","CA209009-14-89_baseline":"50.870","CA209009-14-98_baseline":"44.328","CA209009-14-107_baseline":"33.101","CA209009-15-75_baseline":"39.826","CA209009-15-76_baseline":"75.531","CA209009-15-77_baseline":"57.396","CA209009-15-81_baseline":"47.397","CA209009-15-83_baseline":"46.710","CA209009-15-94_baseline":"45.521","CA209009-1-20_week 4":"49.640","CA209009-1-32_week 4":"81.576","CA209009-1-43_week 4":"35.051","CA209009-1-62_week 4":"42.371","CA209009-1-72_week 4":"9.309","CA209009-1-86_week 4":"22.141","CA209009-1-118_week 4":"41.332","CA209009-2-48_week 4":"43.966","CA209009-2-58_week 4":"16.453","CA209009-2-64_week 4":"47.975","CA209009-2-84_week 4":"31.020","CA209009-2-85_week 4":"38.156","CA209009-2-102_week 4":"52.716","CA209009-3-15_week 4":"50.695","CA209009-3-114_week 4":"57.435","CA209009-3-117_week 4":"78.118","CA209009-4-49_week 4":"73.182","CA209009-4-54_week 4":"16.017","CA209009-4-68_week 4":"56.838","CA209009-4-95_week 4":"42.348","CA209009-5-1_week 4":"33.087","CA209009-5-3_week 4":"19.636","CA209009-5-4_week 4":"54.240","CA209009-5-6_week 4":"33.933","CA209009-5-17_week 4":"47.524","CA209009-5-18_week 4":"70.162","CA209009-5-21_week 4":"33.037","CA209009-5-22_week 4":"47.418","CA209009-5-23_week 4":"60.177","CA209009-5-28_week 4":"19.981","CA209009-5-29_week 4":"38.707","CA209009-5-41_week 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ID":"HMDB0011410"},{"Metabolite":"C36:3 PE plasmalogen","quantitated m/z":"728.5578","retention times":"5.71","HMDB ID":"HMDB0011441"},{"Metabolite":"C38:7 PE plasmalogen","quantitated m/z":"748.5265","retention times":"5.65","HMDB ID":"HMDB0011420"},{"Metabolite":"C38:6 PE plasmalogen","quantitated m/z":"750.5419","retention times":"5.64","HMDB ID":"HMDB0011387"},{"Metabolite":"C38:5 PE plasmalogen","quantitated m/z":"752.5572","retention times":"5.64","HMDB ID":"HMDB0011386"},{"Metabolite":"C40:7 PE plasmalogen","quantitated m/z":"776.5573","retention times":"5.63","HMDB ID":"HMDB0011394"},{"Metabolite":"C36:2 PS plasmalogen","quantitated m/z":"774.5632","retention times":"6.89","HMDB ID":""},{"Metabolite":"C16:0 ceramide (d18:1)","quantitated m/z":"538.519","retention times":"1.92","HMDB ID":"HMDB0004949"},{"Metabolite":"C24:1 ceramide (d18:1)","quantitated m/z":"648.6282","retention times":"1.86","HMDB ID":"HMDB0004953"},{"Metabolite":"C14:0 SM","quantitated 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}

}