{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001527","ANALYSIS_ID":"AN002549","VERSION":"1","CREATED_ON":"November 13, 2020, 10:00 am"},

"PROJECT":{"PROJECT_TITLE":"Lung cancer metabolomics analysis","PROJECT_TYPE":"MS untargeted analysis","PROJECT_SUMMARY":"This study explored models predictive of staging and chemotherapy response based on metabolomic analysis of fresh, patient-derived non-small cell lung cancer (NSCLC) core biopsies. Prospectively collected tissue samples before initial treatment were evaluated with high-resolution 2DLC-MS/MS and the data were comprehensively analyzed with machine learning techniques. Patients were categorized as Disease-Control (DC) [encompassing complete-response (CR), partial-response (PR), and stable-disease (SD)] and Progressive-Disease (PD). Four major types of learning methods (partial least squares discriminant analysis (PLS-DA), support vector machines (SVM), artificial neural networks, and random forests) were applied to differentiate between positive (DC and CR/PR) and poor (PD and SD/PD) responses, and between stage I/II/III and stage IV disease. Models were trained with forward feature selection based on variable importance and tested on validation subsets.","INSTITUTE":"University of Louisville","DEPARTMENT":"Bioengineering","LAST_NAME":"Frieboes","FIRST_NAME":"Hermann","ADDRESS":"Lutz Hall 419","EMAIL":"hbfrie01@louisville.edu","PHONE":"502-852-3302","FUNDING_SOURCE":"NIH/NCI R15CA203605"},

"STUDY":{"STUDY_TITLE":"Lung cancer metabolomics analysis","STUDY_SUMMARY":"This study explored models predictive of staging and chemotherapy response based on metabolomic analysis of fresh, patient-derived non-small cell lung cancer (NSCLC) core biopsies. Prospectively collected tissue samples before initial treatment were evaluated with high-resolution 2DLC-MS/MS and 13C-glucose enrichment, and the data were comprehensively analyzed with machine learning techniques. Patients were categorized as Disease-Control (DC) [encompassing complete-response (CR), partial-response (PR), and stable-disease (SD)] and Progressive-Disease (PD). Four major types of learning methods (partial least squares discriminant analysis (PLS-DA), support vector machines (SVM), artificial neural networks, and random forests) were applied to differentiate between positive (DC and CR/PR) and poor (PD and SD/PD) responses, and between stage I/II/III and stage IV disease. Models were trained with forward feature selection based on variable importance and tested on validation subsets.","INSTITUTE":"University of Louisville","DEPARTMENT":"Bioengineering","LAST_NAME":"Frieboes","FIRST_NAME":"Hermann","ADDRESS":"Lutz Hall 419","EMAIL":"hbfrie01@louisville.edu","PHONE":"502-852-3302"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"Patient_01",
"Sample ID":"CDSR00861_01_neg",
"Factors":{"Tumor_staging_before_chemo":"1","Chemo_response_numeric":"1"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR00861_01_neg.RAW"}
},
{
"Subject ID":"Patient_01",
"Sample ID":"CDSR00861_01_pos",
"Factors":{"Tumor_staging_before_chemo":"1","Chemo_response_numeric":"1"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR00861_01_pos.RAW"}
},
{
"Subject ID":"Patient_02",
"Sample ID":"CDSR00877_01_neg",
"Factors":{"Tumor_staging_before_chemo":"2","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR00877_01_neg.RAW"}
},
{
"Subject ID":"Patient_02",
"Sample ID":"CDSR00877_01_pos",
"Factors":{"Tumor_staging_before_chemo":"2","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR00877_01_pos.RAW"}
},
{
"Subject ID":"Patient_03",
"Sample ID":"CDSR00894_01_neg",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR00894_01_neg.RAW"}
},
{
"Subject ID":"Patient_03",
"Sample ID":"CDSR00894_01_pos",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR00894_01_pos_RAW"}
},
{
"Subject ID":"Patient_04",
"Sample ID":"CDSR01023_01_neg",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"4"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01023_01_neg.RAW"}
},
{
"Subject ID":"Patient_04",
"Sample ID":"CDSR01023_01_pos",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"4"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01023_01_pos.RAW"}
},
{
"Subject ID":"Patient_05",
"Sample ID":"CDSR01042_01_neg",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01042_01_neg.RAW"}
},
{
"Subject ID":"Patient_05",
"Sample ID":"CDSR01042_01_pos",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01042_01_pos.RAW"}
},
{
"Subject ID":"Patient_06",
"Sample ID":"CDSR01092-01_neg",
"Factors":{"Tumor_staging_before_chemo":"2","Chemo_response_numeric":"1"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01092-01_neg.RAW"}
},
{
"Subject ID":"Patient_06",
"Sample ID":"CDSR01092-01_pos",
"Factors":{"Tumor_staging_before_chemo":"2","Chemo_response_numeric":"1"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01092-01_pos.RAW"}
},
{
"Subject ID":"Patient_07",
"Sample ID":"CDSR01154-01_neg",
"Factors":{"Tumor_staging_before_chemo":"1","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01154-01_neg.RAW"}
},
{
"Subject ID":"Patient_07",
"Sample ID":"CDSR01154-01_pos",
"Factors":{"Tumor_staging_before_chemo":"1","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01154-01_pos.RAW"}
},
{
"Subject ID":"Patient_08",
"Sample ID":"CDSR01155-01_neg",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"4"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01155-01_neg.RAW"}
},
{
"Subject ID":"Patient_08",
"Sample ID":"CDSR01155-01_pos",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"4"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01155-01_pos.RAW"}
},
{
"Subject ID":"Patient_09",
"Sample ID":"CDSR01156-01_neg",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01156-01_neg.RAW"}
},
{
"Subject ID":"Patient_09",
"Sample ID":"CDSR01156-01_pos",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01156-01_pos.RAW"}
},
{
"Subject ID":"Patient_10",
"Sample ID":"CDSR01177-01_neg",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01177-01_neg.RAW"}
},
{
"Subject ID":"Patient_10",
"Sample ID":"CDSR01177-01_pos",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01177-01_pos.RAW"}
},
{
"Subject ID":"Patient_11",
"Sample ID":"CDSR01192-01_neg",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01192-01_neg.RAW"}
},
{
"Subject ID":"Patient_11",
"Sample ID":"CDSR01192-01_pos",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01192-01_pos.RAW"}
},
{
"Subject ID":"Patient_12",
"Sample ID":"CDSR01197-01_neg",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01197-01_neg.RAW"}
},
{
"Subject ID":"Patient_12",
"Sample ID":"CDSR01197-01_pos",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01197-01_pos.RAW"}
},
{
"Subject ID":"Patient_13",
"Sample ID":"CDSR01202-02_neg",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"4"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01202-02_neg.RAW"}
},
{
"Subject ID":"Patient_13",
"Sample ID":"CDSR01202-02_pos",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"4"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01202-02_pos.RAW"}
},
{
"Subject ID":"Patient_14",
"Sample ID":"CDSR01256-01_neg",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01256-01_neg.RAW"}
},
{
"Subject ID":"Patient_14",
"Sample ID":"CDSR01256-01_pos",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01256-01_pos.RAW"}
},
{
"Subject ID":"Patient_15",
"Sample ID":"CDSR01257-01_neg",
"Factors":{"Tumor_staging_before_chemo":"2","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01257-01_neg.RAW"}
},
{
"Subject ID":"Patient_15",
"Sample ID":"CDSR01257-01_pos",
"Factors":{"Tumor_staging_before_chemo":"2","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01257-01_pos.RAW"}
},
{
"Subject ID":"Patient_16",
"Sample ID":"CDSR01291-01_neg",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"4"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01291-01_neg.RAW"}
},
{
"Subject ID":"Patient_16",
"Sample ID":"CDSR01291-01_pos",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"4"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01291-01_pos.RAW"}
},
{
"Subject ID":"Patient_17",
"Sample ID":"CDSR01292-01_neg",
"Factors":{"Tumor_staging_before_chemo":"1","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01292-01_neg.RAW"}
},
{
"Subject ID":"Patient_17",
"Sample ID":"CDSR01292-01_pos",
"Factors":{"Tumor_staging_before_chemo":"1","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01292-01_pos.RAW"}
},
{
"Subject ID":"Patient_18",
"Sample ID":"CDSR01382-01_neg",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01382-01_neg.RAW"}
},
{
"Subject ID":"Patient_18",
"Sample ID":"CDSR01382-01_pos",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01382-01_pos.RAW"}
},
{
"Subject ID":"Patient_19",
"Sample ID":"CDSR01405-01_neg",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01405-01_neg.RAW"}
},
{
"Subject ID":"Patient_19",
"Sample ID":"CDSR01405-01_pos",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01405-01_pos.RAW"}
},
{
"Subject ID":"Patient_20",
"Sample ID":"CDSR01563-01_neg",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01563-01_neg.RAW"}
},
{
"Subject ID":"Patient_20",
"Sample ID":"CDSR01563-01_pos",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"CDSR01563-01_pos.RAW"}
},
{
"Subject ID":"Patient_21",
"Sample ID":"N003_neg",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"N003_neg.RAW"}
},
{
"Subject ID":"Patient_21",
"Sample ID":"N003_pos",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"N003_pos.RAW"}
},
{
"Subject ID":"Patient_22",
"Sample ID":"N004_neg",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"N004_neg.RAW"}
},
{
"Subject ID":"Patient_22",
"Sample ID":"N004_pos",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"N004_pos.RAW"}
},
{
"Subject ID":"Patient_23",
"Sample ID":"N010_neg",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"N010_neg.RAW"}
},
{
"Subject ID":"Patient_23",
"Sample ID":"N010_pos",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"N010_pos.RAW"}
},
{
"Subject ID":"Patient_24",
"Sample ID":"N017_neg",
"Factors":{"Tumor_staging_before_chemo":"-","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N017_neg.RAW"}
},
{
"Subject ID":"Patient_24",
"Sample ID":"N017_pos",
"Factors":{"Tumor_staging_before_chemo":"-","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N017_pos.RAW"}
},
{
"Subject ID":"Patient_25",
"Sample ID":"N018_neg",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"N018_neg.RAW"}
},
{
"Subject ID":"Patient_25",
"Sample ID":"N018_pos",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"N018_pos.RAW"}
},
{
"Subject ID":"Patient_26",
"Sample ID":"N020_neg",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"N020_neg.RAW"}
},
{
"Subject ID":"Patient_26",
"Sample ID":"N020_pos",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"N020_pos.RAW"}
},
{
"Subject ID":"Patient_27",
"Sample ID":"N023_neg",
"Factors":{"Tumor_staging_before_chemo":"1","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N023_neg.RAW"}
},
{
"Subject ID":"Patient_27",
"Sample ID":"N023_pos",
"Factors":{"Tumor_staging_before_chemo":"1","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N023_pos.RAW"}
},
{
"Subject ID":"Patient_28",
"Sample ID":"N026_neg",
"Factors":{"Tumor_staging_before_chemo":"1","Chemo_response_numeric":"1"},
"Additional sample data":{"RAW_FILE_NAME":"N026_neg.RAW"}
},
{
"Subject ID":"Patient_28",
"Sample ID":"N026_pos",
"Factors":{"Tumor_staging_before_chemo":"1","Chemo_response_numeric":"1"},
"Additional sample data":{"RAW_FILE_NAME":"N026_pos.RAW"}
},
{
"Subject ID":"Patient_29",
"Sample ID":"N032_neg",
"Factors":{"Tumor_staging_before_chemo":"1","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N032_neg.RAW"}
},
{
"Subject ID":"Patient_29",
"Sample ID":"N032_pos",
"Factors":{"Tumor_staging_before_chemo":"1","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N032_pos.RAW"}
},
{
"Subject ID":"Patient_30",
"Sample ID":"N030_neg",
"Factors":{"Tumor_staging_before_chemo":"-","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N030_neg.RAW"}
},
{
"Subject ID":"Patient_30",
"Sample ID":"N030_pos",
"Factors":{"Tumor_staging_before_chemo":"-","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N030_pos.RAW"}
},
{
"Subject ID":"Patient_31",
"Sample ID":"N034_neg",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"N034_neg.RAW"}
},
{
"Subject ID":"Patient_31",
"Sample ID":"N034_pos",
"Factors":{"Tumor_staging_before_chemo":"3","Chemo_response_numeric":"3"},
"Additional sample data":{"RAW_FILE_NAME":"N034_pos.RAW"}
},
{
"Subject ID":"Patient_32",
"Sample ID":"N035_neg",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"N035_neg.RAW"}
},
{
"Subject ID":"Patient_32",
"Sample ID":"N035_pos",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"N035_pos.RAW"}
},
{
"Subject ID":"Patient_33",
"Sample ID":"N039_neg",
"Factors":{"Tumor_staging_before_chemo":"2","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N039_neg.RAW"}
},
{
"Subject ID":"Patient_33",
"Sample ID":"N039_pos",
"Factors":{"Tumor_staging_before_chemo":"2","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N039_pos.RAW"}
},
{
"Subject ID":"Patient_34",
"Sample ID":"N045_neg",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N045_neg.RAW"}
},
{
"Subject ID":"Patient_34",
"Sample ID":"N045_pos",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N045_pos.RAW"}
},
{
"Subject ID":"Patient_35",
"Sample ID":"N046_neg",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"N046_neg.RAW"}
},
{
"Subject ID":"Patient_35",
"Sample ID":"N046_pos",
"Factors":{"Tumor_staging_before_chemo":"4","Chemo_response_numeric":"2"},
"Additional sample data":{"RAW_FILE_NAME":"N046_pos.RAW"}
},
{
"Subject ID":"Patient_36",
"Sample ID":"N051_neg",
"Factors":{"Tumor_staging_before_chemo":"2","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N051_neg.RAW"}
},
{
"Subject ID":"Patient_36",
"Sample ID":"N051_pos",
"Factors":{"Tumor_staging_before_chemo":"2","Chemo_response_numeric":"-"},
"Additional sample data":{"RAW_FILE_NAME":"N051_pos.RAW"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Tumor tissue samples were placed in a 1.8mL cryovial with either DMEM or RPMI cell culture medium and kept on ice during transport. In the laboratory, they were immediately placed into 1mL 13C labeled glucose medium in 24-well cell culture plate and incubated at 5% CO2 and 37oC on a shaker for 24h.","SAMPLE_TYPE":"Tumor cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"Patients received chemotherapy post tumor tissue collection. Chemotherapy varied based on patient-specific conditions. Information regarding chemotherapy outcome in terms of complete regression (1), partial regression (2), stable disease (3), or progressive disease (4) was collected after chemotherapy regimen was completed."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"After incubation, media and tissue sample were transferred to 1.5mL microcentrifuge tube and centrifuged for 5min. 13C-glucose media was aspirated and specimen was washed with PBS and centrifuged for 5min, twice. After wash, 500mL acetonitrile was added and tissue was homogenized with pellet mixer. After 2-3min homogenization, 376mL of DNase/RNase free water and 250mL chloroform were added. Contents were vortexed until milky-white color and centrifuged for 20min. Top (polar) layer was aspirated and frozen at -80oC. As control, a NSCLC tissue biopsy was incubated in unlabeled glucose media for 24h and processed likewise. Sample polar layers were flash frozen in liquid N2, then lyophilized for 24-48h until dried"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Used a reversed phase chromatography (RPC) column and a hydrophilic interaction chromatography (HILIC) column configured to form a parallel 2DLC-MS system","CHROMATOGRAPHY_TYPE":"Parallel 2DLC-MS","INSTRUMENT_NAME":"Thermo Dionex Ultimate 3000","COLUMN_NAME":"Thermo Accucore HILIC (100 x 2.1mm, 2.6um)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive HF hybrid Orbitrap","INSTRUMENT_TYPE":"Single quadrupole","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"-"},

"MS_METABOLITE_DATA":{
"Units":"peak intensity",

"Data":[false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false],

"Metabolites":[{"metabolite_name":"HODE_analog"},{"metabolite_name":"(S) HODE"},{"metabolite_name":"(R)-2-Hydroxybutyric acid"},{"metabolite_name":"Hydroxybutyric acid_analog_1"},{"metabolite_name":"(S)-(+)-1,2-Isopropylideneglycerol"},{"metabolite_name":"1-Methyl-L-histidine"},{"metabolite_name":"12-Aminododecanoic acid"},{"metabolite_name":"13C (R)-2-Hydroxybutyric acid"},{"metabolite_name":"13C Hydroxybutyric acid_analog_01"},{"metabolite_name":"13C 2-Aminobutyric acid"},{"metabolite_name":"13C Hydroxybutyric acid_analog_02"},{"metabolite_name":"13C 3-Hydroxypyridine"},{"metabolite_name":"13C 3-Phenyllactic acid"},{"metabolite_name":"13C 4-Guanidinobutyric acid"},{"metabolite_name":"13C L-Pyroglutamic acid_analog_1"},{"metabolite_name":"13C 5-Aminovaleric acid"},{"metabolite_name":"13C 5-Aminovaleric acid_analog"},{"metabolite_name":"13C 5-CMP"},{"metabolite_name":"13C 5-Hydroxytryptophan"},{"metabolite_name":"13C Acetyl-L-carnitine"},{"metabolite_name":"13C Acetylcholine"},{"metabolite_name":"13C Adenine"},{"metabolite_name":"13C Adenosine"},{"metabolite_name":"13C Adenosine 5'-monophosphate"},{"metabolite_name":"13C Adipic acid"},{"metabolite_name":"13C Adonitol"},{"metabolite_name":"13C Alanine"},{"metabolite_name":"13C Alanine_analog"},{"metabolite_name":"13C alpha-Amino-n-butyric acid"},{"metabolite_name":"13C alpha-D-Glucose1-phosphate_analog"},{"metabolite_name":"13C alpha-Glycerol phosphate"},{"metabolite_name":"13C alpha-Ketoglutarate"},{"metabolite_name":"13C Arginine"},{"metabolite_name":"13C Asparagine"},{"metabolite_name":"13C Aspartic acid"},{"metabolite_name":"13C Aspartic Acid"},{"metabolite_name":"13C Azelaic acid"},{"metabolite_name":"13C Benzoic acid"},{"metabolite_name":"13C Betain"},{"metabolite_name":"13C Betaine"},{"metabolite_name":"13C Betaine_analog"},{"metabolite_name":"13C Carnitine"},{"metabolite_name":"13C Choline"},{"metabolite_name":"13C cis-Aconitate"},{"metabolite_name":"13C cis-Aconitic acid"},{"metabolite_name":"13C Citraconic acid"},{"metabolite_name":"13C Citrate"},{"metabolite_name":"13C Citric acid"},{"metabolite_name":"13C Citrulline"},{"metabolite_name":"13C Coenzyme Q1"},{"metabolite_name":"13C Creatine"},{"metabolite_name":"13C Creatinine"},{"metabolite_name":"13C Cystathionine"},{"metabolite_name":"13C Cystine"},{"metabolite_name":"13C D-(+)-Malic acid"},{"metabolite_name":"13C D-Fructose-1,6-Bisphosphate (F1,6BP)"},{"metabolite_name":"13C D-Fructose-1,6-Bisphosphate (F1,6BP)_analog"},{"metabolite_name":"13C D-Fructose-6-Phosphate (F6P)_analog_1"},{"metabolite_name":"13C D-Fructose-6-Phosphate (F6P)_analog_2"},{"metabolite_name":"13C D-Glucose-6-Phosphate (G6P)"},{"metabolite_name":"13C D-Glucose-6-Phosphate(G6P)_analog"},{"metabolite_name":"13C D-Glucose (Glc)_analog"},{"metabolite_name":"13C D-Ribulose-5-phosphate"},{"metabolite_name":"13C DL-Glyceraldehyde 3-phosphate"},{"metabolite_name":"13C DL-β-Leucine"},{"metabolite_name":"13C DL-p-Hydroxyphenyllactic acid"},{"metabolite_name":"13C Eicosapentaenoic acid"},{"metabolite_name":"13C Eicosapentaenoic acid (EPA)"},{"metabolite_name":"13C Folic acid"},{"metabolite_name":"13C Fructose"},{"metabolite_name":"13C Fructose_analog_1"},{"metabolite_name":"13C Fructose_analog_2"},{"metabolite_name":"13C G (Guanosine)"},{"metabolite_name":"13C Gluconic acid"},{"metabolite_name":"13C Glucose"},{"metabolite_name":"13C Glutamic acid"},{"metabolite_name":"13C Glutamine"},{"metabolite_name":"13C Glutaric acid"},{"metabolite_name":"13C Glutaryl-L-carnitine"},{"metabolite_name":"13C Glutathione"},{"metabolite_name":"13C Glyceraldehyde 3-phosphate"},{"metabolite_name":"13C Guaiacol"},{"metabolite_name":"13C Guanine"},{"metabolite_name":"13C Guanosine"},{"metabolite_name":"13C Histamine"},{"metabolite_name":"13C Histidine"},{"metabolite_name":"13C Hypoxanthine"},{"metabolite_name":"13C Hypoxanthine_analog"},{"metabolite_name":"13C α-D-Glucose-1,6-bisphosphate"},{"metabolite_name":"13C Inosine"},{"metabolite_name":"13C Isocitrate"},{"metabolite_name":"13C Isoleucine"},{"metabolite_name":"13C Itaconic acid"},{"metabolite_name":"13C L-alpha-Amino-n-butyric acid"},{"metabolite_name":"13C L-alpha-Aminoadipic acid"},{"metabolite_name":"13C L-Glutathione (reduced)"},{"metabolite_name":"13C L-Glutathione oxidized"},{"metabolite_name":"13C Proline_analog"},{"metabolite_name":"13C L-Pyroglutamic acid"},{"metabolite_name":"13C L-Pyroglutamic acid_analog_2"},{"metabolite_name":"13C L-Threonic acid"},{"metabolite_name":"13C Lactate"},{"metabolite_name":"13C Leucine"},{"metabolite_name":"13C Leucine_analog_1"},{"metabolite_name":"13C Leucine_analog_2"},{"metabolite_name":"13C Levulinic acid"},{"metabolite_name":"13C Linolenic acid"},{"metabolite_name":"13C Lysine"},{"metabolite_name":"13C Malate"},{"metabolite_name":"13C Malic acid"},{"metabolite_name":"13C Mannose"},{"metabolite_name":"13C Methionine"},{"metabolite_name":"13C Methionine sulfoxide"},{"metabolite_name":"13C N-Acetyl-DL-glutamic acid"},{"metabolite_name":"13C N-Acetyl-L-glutamic acid"},{"metabolite_name":"13C N-Acetylneuraminic acid"},{"metabolite_name":"13C N-Isovalerylglycine"},{"metabolite_name":"13C N1-Acetylspermine"},{"metabolite_name":"13C Methylguanosine"},{"metabolite_name":"13C N3,N4-Dimethyl-L-arginine"},{"metabolite_name":"13C N6-Acetyl-L-lysine"},{"metabolite_name":"13C N6,N6,N6-Trimethyl-L-lysine"},{"metabolite_name":"13C N8-Acetylspermidine"},{"metabolite_name":"13C Niacinamide"},{"metabolite_name":"13C Nicotinamide"},{"metabolite_name":"13C O-Acetylserine"},{"metabolite_name":"13C O-Phosphoethanolamine"},{"metabolite_name":"13C Oleamide"},{"metabolite_name":"13C Ornithine"},{"metabolite_name":"13C Pantothenic acid"},{"metabolite_name":"13C Phenylalanine"},{"metabolite_name":"13C Phenylpyruvic Acid"},{"metabolite_name":"13C Pinolenic Acid"},{"metabolite_name":"13C Proline"},{"metabolite_name":"13C Propionylcarnitine"},{"metabolite_name":"13C Pyridoxal"},{"metabolite_name":"13C Pyridoxine"},{"metabolite_name":"13C Pyroglutamic acid"},{"metabolite_name":"13C Pyruvate"},{"metabolite_name":"13C Ribose"},{"metabolite_name":"13C Salicylic acid"},{"metabolite_name":"13C Salsolinol"},{"metabolite_name":"13C Sarcosine"},{"metabolite_name":"13C Serine"},{"metabolite_name":"13C Sorbitol"},{"metabolite_name":"13C Spermidine"},{"metabolite_name":"13C Spermine"},{"metabolite_name":"13C Succinate"},{"metabolite_name":"13C Succinate_analog"},{"metabolite_name":"13C Succinic acid"},{"metabolite_name":"13C Sucrose"},{"metabolite_name":"13C Taurine"},{"metabolite_name":"13C Thiamine"},{"metabolite_name":"13C Threonine"},{"metabolite_name":"13C trans-Ferulic acid"},{"metabolite_name":"13C Tryptophan"},{"metabolite_name":"13C Tyrosine"},{"metabolite_name":"13C UDP-Glucose"},{"metabolite_name":"13C UDP-N-acetylglucosamine"},{"metabolite_name":"13C Urea"},{"metabolite_name":"13C Uric acid"},{"metabolite_name":"13C Uridine"},{"metabolite_name":"13C Urocanic acid"},{"metabolite_name":"13C Urocanic acid_analog"},{"metabolite_name":"13C Vaccenic Acid"},{"metabolite_name":"13C Valine"},{"metabolite_name":"13C Xanthine"},{"metabolite_name":"13C Y (Pseudouridine)"},{"metabolite_name":"2'-O-Methyladenosine"},{"metabolite_name":"2-Aminoadipic acid"},{"metabolite_name":"2-Aminoadipic acid_analog"},{"metabolite_name":"Aminobutyricacid"},{"metabolite_name":"2-Hydroxybutyric acid"},{"metabolite_name":"2-Hydroxycinnamic acid"},{"metabolite_name":"2-Hydroxyvaleric acid"},{"metabolite_name":"2-Ketobutyric acid"},{"metabolite_name":"Aminobutanoic acid"},{"metabolite_name":"Aminobutanoic acid_analog_1"},{"metabolite_name":"Aminobutanoic acid_analog_2"},{"metabolite_name":"3-Hydroxybutyric acid"},{"metabolite_name":"Hydroxybutyric acid_analog_2"},{"metabolite_name":"3-Hydroxypyridine"},{"metabolite_name":"3-Methyl-L-histidine"},{"metabolite_name":"3-Phenyllactic acid"},{"metabolite_name":"3-Ureidopropionic acid"},{"metabolite_name":"4-Acetamidobutanoic acid"},{"metabolite_name":"4-Guanidinobutanoic acid"},{"metabolite_name":"4-Guanidinobutyric acid"},{"metabolite_name":"4-Methyl-2-oxovaleric acid"},{"metabolite_name":"4-Methyl-5-thiazoleethanol"},{"metabolite_name":"4-Nitrophenol"},{"metabolite_name":"4-Oxoproline"},{"metabolite_name":"4-Oxoproline_analog"},{"metabolite_name":"5-Aminovaleric acid"},{"metabolite_name":"5-Aminovaleric acid_analog"},{"metabolite_name":"5-CMP"},{"metabolite_name":"5-Hydroxyindole-3-acetic acid"},{"metabolite_name":"5-Hydroxytryptophan"},{"metabolite_name":"6-Hydroxycaproic acid"},{"metabolite_name":"Acetyl-L-carnitine"},{"metabolite_name":"Acetylcholine"},{"metabolite_name":"Adenine"},{"metabolite_name":"Adenosine"},{"metabolite_name":"Adenosine 5'-monophosphate"},{"metabolite_name":"Adipic acid"},{"metabolite_name":"Adonitol"},{"metabolite_name":"Alanine"},{"metabolite_name":"Alanine_analog"},{"metabolite_name":"alpha-Amino-n-butyric acid"},{"metabolite_name":"alpha-Aminoadipic acid"},{"metabolite_name":"alpha-Glycerol phosphate"},{"metabolite_name":"alpha-Ketoglutarate"},{"metabolite_name":"alpha-Ketoglutaric acid"},{"metabolite_name":"Arachidonic acid (ARA)"},{"metabolite_name":"Arginine"},{"metabolite_name":"Asparagine"},{"metabolite_name":"Aspartic acid"},{"metabolite_name":"Aspartic Acid"},{"metabolite_name":"Azelaic acid"},{"metabolite_name":"Benzoic acid"},{"metabolite_name":"Betain"},{"metabolite_name":"Betaine"},{"metabolite_name":"Betaine_analog"},{"metabolite_name":"Caffeine"},{"metabolite_name":"Carnitine"},{"metabolite_name":"Carvone"},{"metabolite_name":"Choline"},{"metabolite_name":"cis-Aconitate"},{"metabolite_name":"cis-Aconitic acid"},{"metabolite_name":"Citraconic acid"},{"metabolite_name":"Citrate"},{"metabolite_name":"Citric acid"},{"metabolite_name":"Citrulline"},{"metabolite_name":"Coenzyme Q1"},{"metabolite_name":"Creatine"},{"metabolite_name":"Creatinine"},{"metabolite_name":"Cystathionine"},{"metabolite_name":"Cysteine"},{"metabolite_name":"Cystine"},{"metabolite_name":"Cystine_analog"},{"metabolite_name":"Cytidine"},{"metabolite_name":"Cytosine"},{"metabolite_name":"D-(-)-Mannitol"},{"metabolite_name":"D-(-)-Ribose"},{"metabolite_name":"D-(+)-Malic acid"},{"metabolite_name":"D-Fructose-1,6-Bisphosphate (F1,6BP)"},{"metabolite_name":"D-Fructose-1,6-Bisphosphate (F1,6BP)_analog"},{"metabolite_name":"D-Fructose-Phosphate_analog_1"},{"metabolite_name":"D-Fructose-Phosphate_analog_2"},{"metabolite_name":"D-Glucose-6-Phosphate (G6P)"},{"metabolite_name":"D-Glucose-6-Phosphate (G6P)_analog"},{"metabolite_name":"Glucose_analog"},{"metabolite_name":"D-Glyceraldehyde3-Phosphate(GADP)"},{"metabolite_name":"D-Ribulose-5-phosphate"},{"metabolite_name":"Aminoisobutyric acid"},{"metabolite_name":"Decanoic acid"},{"metabolite_name":"Dihydrothymine"},{"metabolite_name":"DL-Glyceraldehyde 3-phosphate"},{"metabolite_name":"DL-β-Leucine"},{"metabolite_name":"DL-p-Hydroxyphenyllactic acid"},{"metabolite_name":"DL-Stachydrine"},{"metabolite_name":"Docosahexaenoic acid (DHA, FAC22:6n3)"},{"metabolite_name":"Dodecanedioic acid"},{"metabolite_name":"Eicosapentaenoic acid (EPA)"},{"metabolite_name":"Estrone"},{"metabolite_name":"Ethanolamine"},{"metabolite_name":"Folic acid"},{"metabolite_name":"Fructose"},{"metabolite_name":"Fructose_analog_1"},{"metabolite_name":"Fructose_analog-2"},{"metabolite_name":"Fumarate"},{"metabolite_name":"Fumarate_analog_1"},{"metabolite_name":"Fumaric acid"},{"metabolite_name":"G (Guanosine)"},{"metabolite_name":"gamma-Amino-n-butyricacid"},{"metabolite_name":"gamma-Aminobutyric acid"},{"metabolite_name":"Gluconic acid"},{"metabolite_name":"Glucose"},{"metabolite_name":"Glucose-6-phosphate"},{"metabolite_name":"Glucose 1-phosphate"},{"metabolite_name":"Glutamic acid"},{"metabolite_name":"Glutamine"},{"metabolite_name":"Glutaric acid"},{"metabolite_name":"Glutaryl-L-carnitine"},{"metabolite_name":"Glutathione"},{"metabolite_name":"Glyceraldehyde 3-phosphate"},{"metabolite_name":"Glycine"},{"metabolite_name":"Guaiacol"},{"metabolite_name":"Guanine"},{"metabolite_name":"Guanosine"},{"metabolite_name":"Hexanoic Acid (FAC6:0)"},{"metabolite_name":"Histamine"},{"metabolite_name":"Histidine"},{"metabolite_name":"Hypoxanthine"},{"metabolite_name":"α-D-Glucose-1,6-bisphosphate"},{"metabolite_name":"Inosine"},{"metabolite_name":"Isobutyric acid"},{"metabolite_name":"Isocitrate"},{"metabolite_name":"Isoleucine"},{"metabolite_name":"Isoleucine_analog"},{"metabolite_name":"Itaconic acid"},{"metabolite_name":"L-alpha-Amino-n-butyric acid"},{"metabolite_name":"L-alpha-Aminoadipic acid"},{"metabolite_name":"L-Glutathione (reduced)"},{"metabolite_name":"L-Glutathione oxidized"},{"metabolite_name":"L-Kynurenine"},{"metabolite_name":"Pipecolinic acid_analog"},{"metabolite_name":"L-Pyroglutamic acid"},{"metabolite_name":"L-Pyroglutamic acid_analog"},{"metabolite_name":"L-Rhamnose_analog"},{"metabolite_name":"L-Threonic acid"},{"metabolite_name":"L-Threonine"},{"metabolite_name":"L-Tryptophan"},{"metabolite_name":"L(-)-Carnitine"},{"metabolite_name":"Lactate"},{"metabolite_name":"Leucine"},{"metabolite_name":"Leucine_analog_1"},{"metabolite_name":"Leucine_analog_2"},{"metabolite_name":"Levulinic acid"},{"metabolite_name":"Lidocaine"},{"metabolite_name":"Linolenic acid"},{"metabolite_name":"Lysine"},{"metabolite_name":"Malate"},{"metabolite_name":"Maleic acid"},{"metabolite_name":"Malic acid"},{"metabolite_name":"Malonic acid"},{"metabolite_name":"Mannitol"},{"metabolite_name":"Methionine"},{"metabolite_name":"Methionine sulfoxide"},{"metabolite_name":"N-Acetyl-alpha-glucosamine phosphate"},{"metabolite_name":"N-Acetyl-D-Glucosamine"},{"metabolite_name":"N-Acetyl-DL-glutamic acid"},{"metabolite_name":"Acetyl-L-glutamic acid"},{"metabolite_name":"N-Acetyl-Glucosamine"},{"metabolite_name":"N-Acetyl-L-glutamic acid"},{"metabolite_name":"N-Acetylneuraminic acid"},{"metabolite_name":"N-Isovalerylglycine"},{"metabolite_name":"N-Phenylacetylglutamine"},{"metabolite_name":"N,N-Dimethylsphingosine"},{"metabolite_name":"N1-Acetylspermine"},{"metabolite_name":"Methylguanosine"},{"metabolite_name":"N3,N4-Dimethyl-L-arginine"},{"metabolite_name":"N6-Acetyl-L-lysine"},{"metabolite_name":"N6,N6,N6-Trimethyl-L-lysine"},{"metabolite_name":"N8-Acetylspermidine"},{"metabolite_name":"Niacinamide"},{"metabolite_name":"Nicotinamide"},{"metabolite_name":"Nicotinamide adenine dinucleotide phosphate (NADP)"},{"metabolite_name":"Nicotinic acid"},{"metabolite_name":"None Hypoglycin A"},{"metabolite_name":"O-Acetylserine"},{"metabolite_name":"O-Phosphoethanolamine"},{"metabolite_name":"O-Phosphorylethanolamine"},{"metabolite_name":"O-Phosphorylethanolamine_analog"},{"metabolite_name":"Oleamide"},{"metabolite_name":"Ornithine"},{"metabolite_name":"Oxalic acid"},{"metabolite_name":"Pantothenic acid"},{"metabolite_name":"Phenylalanine"},{"metabolite_name":"Phenylpyruvic Acid"},{"metabolite_name":"Pinolenic Acid"},{"metabolite_name":"Pipecolic acid"},{"metabolite_name":"Pipecolinic acid"},{"metabolite_name":"Proline"},{"metabolite_name":"Propionylcarnitine"},{"metabolite_name":"Putrescine"},{"metabolite_name":"Pyridoxal"},{"metabolite_name":"Pyridoxine"},{"metabolite_name":"Pyroglutamic acid_analog"},{"metabolite_name":"Pyruvate"},{"metabolite_name":"Pyruvic acid"},{"metabolite_name":"Ribose"},{"metabolite_name":"S-Adenosylhomocysteine"},{"metabolite_name":"Salicylic acid"},{"metabolite_name":"Salsolinol"},{"metabolite_name":"Sarcosine"},{"metabolite_name":"Sarcosine_analog"},{"metabolite_name":"Serine"},{"metabolite_name":"Sorbitol"},{"metabolite_name":"Spermidine"},{"metabolite_name":"Spermine"},{"metabolite_name":"Stearic acid"},{"metabolite_name":"Suberic acid"},{"metabolite_name":"Succinate"},{"metabolite_name":"Succinate_analog"},{"metabolite_name":"Succinic acid"},{"metabolite_name":"Sucrose"},{"metabolite_name":"Tartaric acid"},{"metabolite_name":"Taurine"},{"metabolite_name":"Thiamine"},{"metabolite_name":"Threonine"},{"metabolite_name":"trans-4-Hydroxy-L-proline"},{"metabolite_name":"Hydroxy-proline"},{"metabolite_name":"trans-4-Hydroxy-proline"},{"metabolite_name":"trans-Ferulic acid"},{"metabolite_name":"Tryptophan"},{"metabolite_name":"Tyrosine"},{"metabolite_name":"Ubiquinone Q1_analog"},{"metabolite_name":"UDP-Glucose"},{"metabolite_name":"UDP-N-acetylglucosamine"},{"metabolite_name":"UMP"},{"metabolite_name":"Urea"},{"metabolite_name":"Uric acid"},{"metabolite_name":"Uridine"},{"metabolite_name":"Uridine monophosphate (UMP)"},{"metabolite_name":"Urocanic acid"},{"metabolite_name":"Urocanic acid_analog"},{"metabolite_name":"Vaccenic acid"},{"metabolite_name":"Vaccenic Acid"},{"metabolite_name":"Valine"},{"metabolite_name":"Xanthine"},{"metabolite_name":"Y (Pseudouridine)"}]
}

}