{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001674","ANALYSIS_ID":"AN002732","VERSION":"1","CREATED_ON":"February 2, 2021, 10:52 am"},

"PROJECT":{"PROJECT_TITLE":"Untargeted phospholipid analysis of HeLa silenced for or overexpressing GOLPH3","PROJECT_SUMMARY":"A group of sequentially-acting enzymes operating at the branchpoint among sphingolipid synthetic pathways binds the Golgi-localised oncoprotein GOLPH3. GOLPH3 sorts these enzymes into vesicles for intra-Golgi retro-transport, acting as a component of the cisternae inter-conversion mechanisms. Through these effects, GOLPH3 controls the sub-Golgi localisation, and the lysosomal degradation rate of specific enzymes. Here we evaluated the impact of overexpressing or silencing GOLPH3 on the glycerophospholipid composition of HeLa cells by untargeted lipid analysis.","INSTITUTE":"École polytechnique fédérale de Lausanne (EPFL)","DEPARTMENT":"IBI","LABORATORY":"UPDANGELO","LAST_NAME":"D'Angelo","FIRST_NAME":"Giovanni","ADDRESS":"Station 15, Lausanne, Vaud, 1015, Switzerland","EMAIL":"giovanni.dangelo@epfl.ch","PHONE":"+41 216934276"},

"STUDY":{"STUDY_TITLE":"Untargeted phospholipid analysis of HeLa silenced for or overexpressing GOLPH3","STUDY_SUMMARY":"A group of sequentially-acting enzymes operating at the branchpoint among sphingolipid synthetic pathways binds the Golgi-localised oncoprotein GOLPH3. GOLPH3 sorts these enzymes into vesicles for intra-Golgi retro-transport, acting as a component of the cisternae inter-conversion mechanisms. Through these effects, GOLPH3 controls the sub-Golgi localisation, and the lysosomal degradation rate of specific enzymes. Here we evaluated the impact of overexpressing or silencing GOLPH3 on the glycerophospholipid composition of HeLa cells by untargeted lipid analysis.","INSTITUTE":"École polytechnique fédérale de Lausanne (EPFL)","DEPARTMENT":"IBI","LABORATORY":"UPDANGELO","LAST_NAME":"D'Angelo","FIRST_NAME":"Giovanni","ADDRESS":"Station 15, Lausanne, Vaud, 1015, Switzerland","EMAIL":"giovanni.dangelo@epfl.ch","PHONE":"+41 216934276"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"CTRL_1",
"Factors":{"Treatment":"no treatment"},
"Additional sample data":{"RAW_FILE_NAME":"CTRL_1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"CTRL_2",
"Factors":{"Treatment":"no treatment"},
"Additional sample data":{"RAW_FILE_NAME":"CTRL_2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"GOLPH3_OE_1",
"Factors":{"Treatment":"GOLPH3 overexpression"},
"Additional sample data":{"RAW_FILE_NAME":"GOLPH3_OE_1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"GOLPH3_OE_2",
"Factors":{"Treatment":"GOLPH3 overexpression"},
"Additional sample data":{"RAW_FILE_NAME":"GOLPH3_OE_2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"GOLPH3_KD_1",
"Factors":{"Treatment":"GOLPH3 silencing"},
"Additional sample data":{"RAW_FILE_NAME":"GOLPH3_KD_1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"GOLPH3_KD_2",
"Factors":{"Treatment":"GOLPH3 silencing"},
"Additional sample data":{"RAW_FILE_NAME":"GOLPH3_KD_2.raw"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Cells were collected by scraping after ice cold PBS washes","SAMPLE_TYPE":"HeLa cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"HeLa cells were treated to overexpress or down regulate the protein GOLPH3"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Total lipid extracts were prepared using a standard MTBE protocol followed by a methylamine treatment for total lipid analysis by mass spectrometry. Briefly, cell pellets or viral fractions were resuspended in 100 μL H2O. 360 μL methanol and 1.2 mL of MTBE were added and samples were placed for 10 min on a vortex at 4 C followed by incubation for 1 h at room temperature on a shaker. Phase separation was induced by addition of 200 μL of H2O. After 10 min at room temperature, samples were centrifuged at 1000 g for 10 min. The upper (organic) phase was transferred into a glass tube and the lower phase was re-extracted with 400 μL artificial upper phase [MTBE/methanol/H2O (10:3:1.5, v/v/v)]. The combined organic phases were dried in a vacuum concentrator. Lipids where then resuspended in 500 μL of ChCl3."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Lipid extracts (2 μL injection volume in ChCl3:MeOH 2:1) were separated over an 8 minutes gradient at a flow rate of 200 μL/min on a HILIC Kinetex Column (2.6lm, 2.1 × 50 mm2) on a Shimadzu Prominence UFPLC xr system (Tokyo, Japan). Mobile phase A was acetonitrile:methanol 10:1 (v/v) containing 10 mM ammonium formate and 0.5% formic acid while mobile phase B was deionized water containing 10 mM ammonium formate and 0.5% formic acid. The elution of the gradient began with 5% B at a 200 μL/min flow and increased linearly to 50% B over 7 min, then the elution continued at 50% B for 1.5 min and finally, the column was re-equilibrated for 2.5 min.","CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Shimadzu Prominence UFPLC xr system","COLUMN_NAME":"HILIC Kinetex Column (2.6lm, 2.1 × 50 mm2)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Orbitrap Elite Hybrid Ion Trap-Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"MS data were acquired in full-scan mode at high resolution on a hybrid Orbitrap Elite (Thermo Fisher Scientific, Bremen, Germany). The system was operated at 240,000 resolution (m/z 400) with an AGC set at 1.0E6 and one microscan set at 10-ms maximum injection time. The heated electrospray source HESI II was operated in positive mode at a temperature of 90 C and a source voltage at 4.0KV. Sheath gas and auxiliary gas were set at 20 and 5 arbitrary units, respectively, while the transfer capillary temperature was set to 275 °C. Mass spectrometry data were acquired with LTQ Tuneplus2.7SP2 and treated with Xcalibur 4.0QF2 (Thermo Fisher Scientific). Lipid identification was carried out with Lipid Data Analyzer II (LDA v. 2.6.3, IGB-TUG Graz University) (Hartler et al., 2011). The LDA algorithm identifies peaks by their respective retention time, m/z and intensity. Care was taken to calibrate the instrument regularly to ensure a mass accuracy consistently lower than 3 ppm thereby leaving only few theoretical possibilities for elemental assignment."},

"MS_METABOLITE_DATA":{
"Units":"intensities",

"Data":[{"Metabolite":"GL02_DAG_DGOTheo_56:14_NH4_1 1_880.71771","CTRL_1":"892951.5","CTRL_2":"1713363","GOLPH3_OE_1":"3072369.75","GOLPH3_OE_2":"3029211.75","GOLPH3_KD_1":"2580072.5","GOLPH3_KD_2":"647211.625"},{"Metabolite":"GL02_DAG_2010004_34:1_NH4_1 1_612.55615","CTRL_1":"593224.4375","CTRL_2":"1548995","GOLPH3_OE_1":"2728272.5","GOLPH3_OE_2":"2788473","GOLPH3_KD_1":"2762170.25","GOLPH3_KD_2":"577432.8125"},{"Metabolite":"GL02_DAG_2010049_36:2_NH4_1 1_638.57178","CTRL_1":"365428.3125","CTRL_2":"1808094.125","GOLPH3_OE_1":"3148346","GOLPH3_OE_2":"2817712.5","GOLPH3_KD_1":"3037733.75","GOLPH3_KD_2":"410955.9688"},{"Metabolite":"GL02_DAG_2010001_32:0_NH4_1 1_586.54047","CTRL_1":"613714.25","CTRL_2":"698180.9375","GOLPH3_OE_1":"1070272.375","GOLPH3_OE_2":"1331966.875","GOLPH3_KD_1":"1009177.75","GOLPH3_KD_2":"651277.0625"},{"Metabolite":"GL02_DAG_2010003_34:0_NH4_1 1_614.57178","CTRL_1":"476791.7188","CTRL_2":"774512.875","GOLPH3_OE_1":"1400629.625","GOLPH3_OE_2":"1270643.125","GOLPH3_KD_1":"1000539.875","GOLPH3_KD_2":"454132.5625"},{"Metabolite":"GL03_TAG_TGTheo_38:10_NH4_1 1_664.45715","CTRL_1":"77899840","CTRL_2":"52759376","GOLPH3_OE_1":"83476872","GOLPH3_OE_2":"64113108","GOLPH3_KD_1":"66839132","GOLPH3_KD_2":"46402152"},{"Metabolite":"GL03_TAG_3010083_52:2_NH4_1 1_876.80145","CTRL_1":"3076598.25","CTRL_2":"7724563.5","GOLPH3_OE_1":"12760181","GOLPH3_OE_2":"10692986","GOLPH3_KD_1":"14127506","GOLPH3_KD_2":"3164435"},{"Metabolite":"GL03_TAG_3010005_50:1_NH4_1 1_850.78583","CTRL_1":"2509559.75","CTRL_2":"5862073.5","GOLPH3_OE_1":"5755390.5","GOLPH3_OE_2":"4449627","GOLPH3_KD_1":"9252194","GOLPH3_KD_2":"2442531.75"},{"Metabolite":"GL03_TAG_3010233_54:3_NH4_1 1_902.81714","CTRL_1":"1385123.25","CTRL_2":"3773335.25","GOLPH3_OE_1":"7319395.5","GOLPH3_OE_2":"6793415","GOLPH3_KD_1":"5935368","GOLPH3_KD_2":"1234666.625"},{"Metabolite":"GL03_TAG_3010032_50:2_NH4_1 1_848.77014","CTRL_1":"1212589.25","CTRL_2":"3831283.25","GOLPH3_OE_1":"4947030.5","GOLPH3_OE_2":"3589706.75","GOLPH3_KD_1":"6969651.5","GOLPH3_KD_2":"1402266.75"},{"Metabolite":"GL03_TAG_TGOTheo_64:20_NH4_1 1_994.72827","CTRL_1":"3779710.25","CTRL_2":"1748572.25","GOLPH3_OE_1":"3688647.75","GOLPH3_OE_2":"3623820.5","GOLPH3_KD_1":"2459016.25","GOLPH3_KD_2":"2563816.25"},{"Metabolite":"GL03_TAG_3010017_48:1_NH4_1 1_822.75452","CTRL_1":"1074054.5","CTRL_2":"2917685","GOLPH3_OE_1":"2443954.5","GOLPH3_OE_2":"2366192.5","GOLPH3_KD_1":"5286004","GOLPH3_KD_2":"1001815.375"},{"Metabolite":"GL03_TAG_3010099_52:3_NH4_1 1_874.78583","CTRL_1":"748877.5","CTRL_2":"2137563.25","GOLPH3_OE_1":"3101121","GOLPH3_OE_2":"2976498.75","GOLPH3_KD_1":"4202738","GOLPH3_KD_2":"1091489.875"},{"Metabolite":"GL03_TAG_TGTheo_29:7_NH4_1 1_544.36328","CTRL_1":"1869369.625","CTRL_2":"2072251.875","GOLPH3_OE_1":"2138317.75","GOLPH3_OE_2":"2236701.25","GOLPH3_KD_1":"1697356.875","GOLPH3_KD_2":"1197999.25"},{"Metabolite":"GL03_TAG_3010203_54:2_NH4_1 1_904.83276","CTRL_1":"835732.0625","CTRL_2":"1656529.25","GOLPH3_OE_1":"3288281.25","GOLPH3_OE_2":"2855082","GOLPH3_KD_1":"3287183.25","GOLPH3_KD_2":"873637.0625"},{"Metabolite":"GL03_TAG_3010071_52:1_NH4_1 1_878.81714","CTRL_1":"1052826.25","CTRL_2":"1896291.875","GOLPH3_OE_1":"2142652.75","GOLPH3_OE_2":"1911792.125","GOLPH3_KD_1":"3678522.25","GOLPH3_KD_2":"1056840"},{"Metabolite":"GL03_TAG_TGdOTheo_56:14_NH4_1 1_880.71771","CTRL_1":"892951.5","CTRL_2":"1713363","GOLPH3_OE_1":"3072369.75","GOLPH3_OE_2":"3029211.75","GOLPH3_KD_1":"2580072.5","GOLPH3_KD_2":"647211.625"},{"Metabolite":"GL03_TAG_TGOTheo_34:1_NH4_1 1_612.55615","CTRL_1":"593224.4375","CTRL_2":"1548995","GOLPH3_OE_1":"2728272.5","GOLPH3_OE_2":"2788473","GOLPH3_KD_1":"2762170.25","GOLPH3_KD_2":"577432.8125"},{"Metabolite":"GL03_TAG_TGTheo_34:10_NH4_1 1_608.39453","CTRL_1":"1689843.75","CTRL_2":"1426876.875","GOLPH3_OE_1":"2081597.25","GOLPH3_OE_2":"1276056.25","GOLPH3_KD_1":"1575631.25","GOLPH3_KD_2":"1015336.5"},{"Metabolite":"GL03_TAG_TGOTheo_36:2_NH4_1 1_638.57178","CTRL_1":"365428.3125","CTRL_2":"1808094.125","GOLPH3_OE_1":"3148346","GOLPH3_OE_2":"2817712.5","GOLPH3_KD_1":"3037733.75","GOLPH3_KD_2":"410955.9688"},{"Metabolite":"GL03_TAG_3010001_48:0_NH4_1 1_824.77014","CTRL_1":"716335.5625","CTRL_2":"1685073.5","GOLPH3_OE_1":"1264812","GOLPH3_OE_2":"1226022.5","GOLPH3_KD_1":"2471782","GOLPH3_KD_2":"672140.0625"},{"Metabolite":"GL03_TAG_3010004_50:0_NH4_1 1_852.80145","CTRL_1":"535684.5625","CTRL_2":"873805.6875","GOLPH3_OE_1":"1340778.75","GOLPH3_OE_2":"1227548.375","GOLPH3_KD_1":"1120342.125","GOLPH3_KD_2":"510721.8125"},{"Metabolite":"GL03_TAG_TGOTheo_32:0_NH4_1 1_586.54047","CTRL_1":"613714.25","CTRL_2":"698180.9375","GOLPH3_OE_1":"1070272.375","GOLPH3_OE_2":"1331966.875","GOLPH3_KD_1":"1009177.75","GOLPH3_KD_2":"651277.0625"},{"Metabolite":"GL03_TAG_TGOTheo_34:0_NH4_1 1_614.57178","CTRL_1":"476791.7188","CTRL_2":"774512.875","GOLPH3_OE_1":"1400629.625","GOLPH3_OE_2":"1270643.125","GOLPH3_KD_1":"1000539.875","GOLPH3_KD_2":"454132.5625"},{"Metabolite":"GL03_TAG_3010018_48:2_NH4_1 1_820.73883","CTRL_1":"303362.2813","CTRL_2":"1014347.25","GOLPH3_OE_1":"838164.375","GOLPH3_OE_2":"1100738.375","GOLPH3_KD_1":"1786460.75","GOLPH3_KD_2":"477394.125"},{"Metabolite":"GL03_TAG_3010266_54:4_NH4_1 1_900.80145","CTRL_1":"464333.5625","CTRL_2":"518519.7813","GOLPH3_OE_1":"727898.8125","GOLPH3_OE_2":"835501.875","GOLPH3_KD_1":"945717.125","GOLPH3_KD_2":"462726.25"},{"Metabolite":"GL03_TAG_3010037_50:3_NH4_1 1_846.75452","CTRL_1":"255009.9219","CTRL_2":"597382","GOLPH3_OE_1":"767045.8125","GOLPH3_OE_2":"732644.8125","GOLPH3_KD_1":"1121601.5","GOLPH3_KD_2":"245011.5469"},{"Metabolite":"GP01_PC_1010005_34:1_H_1 1_760.58508","CTRL_1":"205619232","CTRL_2":"345358144","GOLPH3_OE_1":"696787520","GOLPH3_OE_2":"552147072","GOLPH3_KD_1":"601903424","GOLPH3_KD_2":"71289200"},{"Metabolite":"GP01_PC_1010764_36:2_H_1 1_786.60071","CTRL_1":"59478560","CTRL_2":"192875856","GOLPH3_OE_1":"453701632","GOLPH3_OE_2":"341161344","GOLPH3_KD_1":"362007136","GOLPH3_KD_2":"22104926"},{"Metabolite":"GP01_PC_1010490_32:1_H_1 2_732.55377","CTRL_1":"100721520","CTRL_2":"164244144","GOLPH3_OE_1":"328054496","GOLPH3_OE_2":"251746272","GOLPH3_KD_1":"20039284","GOLPH3_KD_2":"35523576"},{"Metabolite":"GP01_PC_1010585_34:2_H_1 1_758.5694","CTRL_1":"63489096","CTRL_2":"99445512","GOLPH3_OE_1":"186674720","GOLPH3_OE_2":"146702640","GOLPH3_KD_1":"175095648","GOLPH3_KD_2":"24517654"},{"Metabolite":"GP01_PC_1010397_32:0_H_1 1_734.5694","CTRL_1":"86421416","CTRL_2":"75297400","GOLPH3_OE_1":"176015296","GOLPH3_OE_2":"128042624","GOLPH3_KD_1":"115614336","GOLPH3_KD_2":"22942934"},{"Metabolite":"GP01_PC_1010395_30:0_H_1 1_706.53815","CTRL_1":"40778872","CTRL_2":"62346312","GOLPH3_OE_1":"143139808","GOLPH3_OE_2":"98890216","GOLPH3_KD_1":"112908280","GOLPH3_KD_2":"11776293"},{"Metabolite":"GP01_PC_1020003_34:1_H_1 1_746.60583","CTRL_1":"17114346","CTRL_2":"50766684","GOLPH3_OE_1":"135243760","GOLPH3_OE_2":"105819904","GOLPH3_KD_1":"93539808","GOLPH3_KD_2":"4892604"},{"Metabolite":"GP01_PC_1010750_36:1_H_1 1_788.61639","CTRL_1":"20721750","CTRL_2":"26277692","GOLPH3_OE_1":"100131600","GOLPH3_OE_2":"75157608","GOLPH3_KD_1":"75357080","GOLPH3_KD_2":"8265608.5"},{"Metabolite":"GP01_PC_1010622_36:3_H_1 2_784.58508","CTRL_1":"32039722","CTRL_2":"22535954","GOLPH3_OE_1":"43561804","GOLPH3_OE_2":"32951608","GOLPH3_KD_1":"45536776","GOLPH3_KD_2":"12809057"},{"Metabolite":"GP01_PC_1010645_38:5_H_1 1_808.58508","CTRL_1":"30504070","CTRL_2":"14037457","GOLPH3_OE_1":"40789464","GOLPH3_OE_2":"28505138","GOLPH3_KD_1":"27647554","GOLPH3_KD_2":"13029944"},{"Metabolite":"GP01_PC_1010007_36:4_H_1 2_782.5694","CTRL_1":"41395884","CTRL_2":"11622743","GOLPH3_OE_1":"25858596","GOLPH3_OE_2":"18782954","GOLPH3_KD_1":"23055760","GOLPH3_KD_2":"16339306"},{"Metabolite":"GP01_PC_1020015_32:0_H_1 1_720.59015","CTRL_1":"7751754.5","CTRL_2":"22959092","GOLPH3_OE_1":"60479968","GOLPH3_OE_2":"39682924","GOLPH3_KD_1":"40155184","GOLPH3_KD_2":"1721135.5"},{"Metabolite":"GP01_PC_1010650_38:6_H_1 1_806.5694","CTRL_1":"24089710","CTRL_2":"8022245.5","GOLPH3_OE_1":"25561900","GOLPH3_OE_2":"19174034","GOLPH3_KD_1":"19229850","GOLPH3_KD_2":"9756235"},{"Metabolite":"GP01_PC_1010541_33:1_H_1 2_746.5694","CTRL_1":"16557862","CTRL_2":"14142167","GOLPH3_OE_1":"28601640","GOLPH3_OE_2":"1997948.25","GOLPH3_KD_1":"29660398","GOLPH3_KD_2":"6436550"},{"Metabolite":"GP01_PC_1010494_32:2_H_1 1_730.53815","CTRL_1":"8128272","CTRL_2":"10879952","GOLPH3_OE_1":"23531440","GOLPH3_OE_2":"16926930","GOLPH3_KD_1":"21648946","GOLPH3_KD_2":"3125977.5"},{"Metabolite":"GP01_PC_1010788_38:2_H_1 1_814.63202","CTRL_1":"3470823.25","CTRL_2":"13862222","GOLPH3_OE_1":"44750944","GOLPH3_OE_2":"31990546","GOLPH3_KD_1":"26969066","GOLPH3_KD_2":"1037678.125"},{"Metabolite":"GP01_PC_1020039_34:2_H_1 1_744.59015","CTRL_1":"5137198","CTRL_2":"15085152","GOLPH3_OE_1":"28986620","GOLPH3_OE_2":"22888158","GOLPH3_KD_1":"16734570","GOLPH3_KD_2":"1638486.25"},{"Metabolite":"GP01_PC_1010642_38:4_H_1 1_810.60071","CTRL_1":"15203830","CTRL_2":"5949251.5","GOLPH3_OE_1":"16120818","GOLPH3_OE_2":"11173991","GOLPH3_KD_1":"11894721","GOLPH3_KD_2":"5704853.5"},{"Metabolite":"GP01_PC_1010440_30:1_H_1 1_704.52246","CTRL_1":"4638427","CTRL_2":"11256822","GOLPH3_OE_1":"21597784","GOLPH3_OE_2":"16771798","GOLPH3_KD_1":"22771372","GOLPH3_KD_2":"1650229.5"},{"Metabolite":"GP01_PC_1011360_35:2_H_1 1_772.58508","CTRL_1":"5455942.5","CTRL_2":"9462687","GOLPH3_OE_1":"18926638","GOLPH3_OE_2":"14478619","GOLPH3_KD_1":"18266018","GOLPH3_KD_2":"2332063"},{"Metabolite":"GP01_PC_1010633_36:5_H_1 1_780.55377","CTRL_1":"21696704","CTRL_2":"4667939.5","GOLPH3_OE_1":"9832374","GOLPH3_OE_2":"6549380","GOLPH3_KD_1":"9376288","GOLPH3_KD_2":"8254786"},{"Metabolite":"GP01_PC_1010711_35:1_H_1 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m/z":"614.57178"},{"Metabolite":"GL03_TAG_3010018_48:2_NH4_1 1_820.73883","Lipid_Class":"TAG","adduct":"NH4","quantitated m/z":"820.73883"},{"Metabolite":"GL03_TAG_3010266_54:4_NH4_1 1_900.80145","Lipid_Class":"TAG","adduct":"NH4","quantitated m/z":"900.80145"},{"Metabolite":"GL03_TAG_3010037_50:3_NH4_1 1_846.75452","Lipid_Class":"TAG","adduct":"NH4","quantitated m/z":"846.75452"},{"Metabolite":"GP01_PC_1010005_34:1_H_1 1_760.58508","Lipid_Class":"PC","adduct":"H","quantitated m/z":"760.58508"},{"Metabolite":"GP01_PC_1010764_36:2_H_1 1_786.60071","Lipid_Class":"PC","adduct":"H","quantitated m/z":"786.60071"},{"Metabolite":"GP01_PC_1010490_32:1_H_1 2_732.55377","Lipid_Class":"PC","adduct":"H","quantitated m/z":"732.55377"},{"Metabolite":"GP01_PC_1010585_34:2_H_1 1_758.5694","Lipid_Class":"PC","adduct":"H","quantitated m/z":"758.5694"},{"Metabolite":"GP01_PC_1010397_32:0_H_1 1_734.5694","Lipid_Class":"PC","adduct":"H","quantitated m/z":"734.5694"},{"Metabolite":"GP01_PC_1010395_30:0_H_1 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m/z":"746.5694"},{"Metabolite":"GP01_PC_1010494_32:2_H_1 1_730.53815","Lipid_Class":"PC","adduct":"H","quantitated m/z":"730.53815"},{"Metabolite":"GP01_PC_1010788_38:2_H_1 1_814.63202","Lipid_Class":"PC","adduct":"H","quantitated m/z":"814.63202"},{"Metabolite":"GP01_PC_1020039_34:2_H_1 1_744.59015","Lipid_Class":"PC","adduct":"H","quantitated m/z":"744.59015"},{"Metabolite":"GP01_PC_1010642_38:4_H_1 1_810.60071","Lipid_Class":"PC","adduct":"H","quantitated m/z":"810.60071"},{"Metabolite":"GP01_PC_1010440_30:1_H_1 1_704.52246","Lipid_Class":"PC","adduct":"H","quantitated m/z":"704.52246"},{"Metabolite":"GP01_PC_1011360_35:2_H_1 1_772.58508","Lipid_Class":"PC","adduct":"H","quantitated m/z":"772.58508"},{"Metabolite":"GP01_PC_1010633_36:5_H_1 1_780.55377","Lipid_Class":"PC","adduct":"H","quantitated m/z":"780.55377"},{"Metabolite":"GP01_PC_1010711_35:1_H_1 1_774.60071","Lipid_Class":"PC","adduct":"H","quantitated m/z":"774.60071"},{"Metabolite":"GP01_PC_1010396_31:0_H_1 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m/z":"742.57452"},{"Metabolite":"GP01_PC_1010696_38:7_H_1 1_804.55377","Lipid_Class":"PC","adduct":"H","quantitated m/z":"804.55377"},{"Metabolite":"GP01_PC_1011459_37:3_H_1 1_798.60071","Lipid_Class":"PC","adduct":"H","quantitated m/z":"798.60071"},{"Metabolite":"GP01_PC_1010394_29:0_H_1 1_692.52246","Lipid_Class":"PC","adduct":"H","quantitated m/z":"692.52246"},{"Metabolite":"GP01_PC_1020058_36:5_H_1 1_766.57452","Lipid_Class":"PC","adduct":"H","quantitated m/z":"766.57452"},{"Metabolite":"GP01_PC_1011423_35:3_H_1 1_770.5694","Lipid_Class":"PC","adduct":"H","quantitated m/z":"770.5694"},{"Metabolite":"GP01_PC_1010512_36:6_H_1 1_778.53815","Lipid_Class":"PC","adduct":"H","quantitated m/z":"778.53815"},{"Metabolite":"GP01_PC_1010003_37:4_H_1 1_796.58508","Lipid_Class":"PC","adduct":"H","quantitated m/z":"796.58508"},{"Metabolite":"GP01_PC_1030040_36:5_H_1 1_764.55884","Lipid_Class":"PC","adduct":"H","quantitated m/z":"764.55884"},{"Metabolite":"GP01_PC_1020107_40:5_H_1 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m/z":"768.55377"},{"Metabolite":"GP02_PE_2030001_38:6_H_1 1_748.52759","Lipid_Class":"PE","adduct":"H","quantitated m/z":"748.52759"},{"Metabolite":"GP02_PE_2010036_36:1_H_1 1_746.5694","Lipid_Class":"PE","adduct":"H","quantitated m/z":"746.5694"},{"Metabolite":"GP02_PE_2010042_34:2_H_1 1_716.52246","Lipid_Class":"PE","adduct":"H","quantitated m/z":"716.52246"},{"Metabolite":"GP02_PE_2020100_34:2_H_1 1_702.54321","Lipid_Class":"PE","adduct":"H","quantitated m/z":"702.54321"},{"Metabolite":"GP02_PE_2010094_40:6_H_1 1_792.55377","Lipid_Class":"PE","adduct":"H","quantitated m/z":"792.55377"},{"Metabolite":"GP02_PE_2020006_38:5_H_1 1_752.55884","Lipid_Class":"PE","adduct":"H","quantitated m/z":"752.55884"},{"Metabolite":"GP02_PE_2030005_40:6_H_1 1_776.55884","Lipid_Class":"PE","adduct":"H","quantitated m/z":"776.55884"},{"Metabolite":"GP02_PE_2030028_36:5_H_1 1_722.5119","Lipid_Class":"PE","adduct":"H","quantitated m/z":"722.5119"},{"Metabolite":"GP02_PE_2010095_38:6_H_1 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}

}