{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001680","ANALYSIS_ID":"AN002741","VERSION":"1","CREATED_ON":"February 3, 2021, 9:48 am"},

"PROJECT":{"PROJECT_TITLE":"Metabolome of NAFLD in high fat diet mouse model","PROJECT_SUMMARY":"We investigated the effects of a RAR beta 2 agonist, AC261066, on the hepatic metabolites changed in high fat fed NAFLD mouse model. We suggest that AC261066 has potential therapeutic relevance for the prevention/treatment of NAFLD and NASH.","INSTITUTE":"Weill Cornell Medical College","LABORATORY":"Lorraine Gudas","LAST_NAME":"Lorraine","FIRST_NAME":"Gudas","ADDRESS":"1300 York Ave, New York, NY, 10065, USA","EMAIL":"chl2029@med.cornell.edu","PHONE":"646-3094389"},

"STUDY":{"STUDY_TITLE":"Metabolome of NAFLD in high fat diet mouse model","STUDY_SUMMARY":"We investigated the effects of a RAR beta 2 agonist, AC261066, on the hepatic metabolites changed in high fat fed NAFLD mouse model. We suggest that AC261066 has potential therapeutic relevance for the prevention/treatment of NAFLD and NASH.","INSTITUTE":"Weill Cornell Medicine","LAST_NAME":"Gudas","FIRST_NAME":"Lorraine","ADDRESS":"1300 York Ave","EMAIL":"chl2029@med.cornell.edu","PHONE":"646-3094389"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"anp-neg-Control-217",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-Control-217"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-Control-217b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-Control-217b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-Control-316",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-Control-316"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-Control-316b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-Control-316b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-Control-317",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-Control-317"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-Control-317b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-Control-317b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-Control-417",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-Control-417"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-Control-417b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-Control-417b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-216",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-216"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-217",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-217"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-217b",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-217b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-316",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-316"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-317",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-317"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-416",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-416"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-417",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-417"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-4217",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-4217"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-Drug-116",
"Factors":{"Treatment":"high fat diet+AC261066"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-Drug-116"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-Drug-116b",
"Factors":{"Treatment":"high fat diet+AC261067"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-Drug-116b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-Drug-217",
"Factors":{"Treatment":"high fat diet+AC261068"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-Drug-217"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-Drug-217b",
"Factors":{"Treatment":"high fat diet+AC261069"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-Drug-217b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-Drug-316",
"Factors":{"Treatment":"high fat diet+AC261070"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-Drug-316"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-Drug-316b",
"Factors":{"Treatment":"high fat diet+AC261071"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-Drug-316b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-Drug-417",
"Factors":{"Treatment":"high fat diet+AC261072"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-Drug-417"}
},
{
"Subject ID":"-",
"Sample ID":"anp-neg-HFD-Drug-417b",
"Factors":{"Treatment":"high fat diet+AC261073"},
"Additional sample data":{"RAW_FILE_NAME":"anp-neg-HFD-Drug-417b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-Control-217",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-Control-217"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-Control-217b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-Control-217b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-Control-316",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-Control-316"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-Control-316b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-Control-316b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-Control-317",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-Control-317"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-Control-317b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-Control-317b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-Control-417",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-Control-417"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-Control-417b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-Control-417b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-216",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-216"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-217",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-217"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-217b",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-217b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-316",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-316"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-317",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-317"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-416",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-416"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-417",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-417"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-4217",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-4217"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-Drug-116",
"Factors":{"Treatment":"high fat diet+AC261066"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-Drug-116"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-Drug-116b",
"Factors":{"Treatment":"high fat diet+AC261067"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-Drug-116b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-Drug-217",
"Factors":{"Treatment":"high fat diet+AC261068"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-Drug-217"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-Drug-217b",
"Factors":{"Treatment":"high fat diet+AC261069"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-Drug-217b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-Drug-316",
"Factors":{"Treatment":"high fat diet+AC261070"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-Drug-316"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-Drug-316b",
"Factors":{"Treatment":"high fat diet+AC261071"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-Drug-316b"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-Drug-417",
"Factors":{"Treatment":"high fat diet+AC261072"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-Drug-417"}
},
{
"Subject ID":"-",
"Sample ID":"anp-pos-HFD-Drug-417b",
"Factors":{"Treatment":"high fat diet+AC261073"},
"Additional sample data":{"RAW_FILE_NAME":"anp-pos-HFD-Drug-417b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-Control-217",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-Control-217"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-Control-217b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-Control-217b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-Control-316",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-Control-316"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-Control-316b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-Control-316b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-Control-317",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-Control-317"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-Control-317b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-Control-317b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-Control-417",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-Control-417"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-Control-417b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-Control-417b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-216",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-216"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-217",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-217"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-217b",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-217b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-316",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-316"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-317",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-317"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-416",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-416"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-417",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-417"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-4217",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-4217"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-Drug-116",
"Factors":{"Treatment":"high fat diet+AC261066"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-Drug-116"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-Drug-116b",
"Factors":{"Treatment":"high fat diet+AC261067"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-Drug-116b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-Drug-217",
"Factors":{"Treatment":"high fat diet+AC261068"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-Drug-217"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-Drug-217b",
"Factors":{"Treatment":"high fat diet+AC261069"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-Drug-217b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-Drug-316",
"Factors":{"Treatment":"high fat diet+AC261070"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-Drug-316"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-Drug-316b",
"Factors":{"Treatment":"high fat diet+AC261071"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-Drug-316b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-Drug-417",
"Factors":{"Treatment":"high fat diet+AC261072"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-Drug-417"}
},
{
"Subject ID":"-",
"Sample ID":"C18-neg-HFD-Drug-417b",
"Factors":{"Treatment":"high fat diet+AC261073"},
"Additional sample data":{"RAW_FILE_NAME":"C18-neg-HFD-Drug-417b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-Control-217",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-Control-217"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-Control-217b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-Control-217b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-Control-316",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-Control-316"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-Control-316b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-Control-316b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-Control-317",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-Control-317"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-Control-317b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-Control-317b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-Control-417",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-Control-417"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-Control-417b",
"Factors":{"Treatment":"chow"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-Control-417b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-216",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-216"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-217",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-217"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-217b",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-217b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-316",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-316"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-317",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-317"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-416",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-416"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-417",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-417"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-4217",
"Factors":{"Treatment":"high fat diet"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-4217"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-Drug-116",
"Factors":{"Treatment":"high fat diet+AC261066"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-Drug-116"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-Drug-116b",
"Factors":{"Treatment":"high fat diet+AC261067"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-Drug-116b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-Drug-217",
"Factors":{"Treatment":"high fat diet+AC261068"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-Drug-217"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-Drug-217b",
"Factors":{"Treatment":"high fat diet+AC261069"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-Drug-217b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-Drug-316",
"Factors":{"Treatment":"high fat diet+AC261070"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-Drug-316"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-Drug-316b",
"Factors":{"Treatment":"high fat diet+AC261071"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-Drug-316b"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-Drug-417",
"Factors":{"Treatment":"high fat diet+AC261072"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-Drug-417"}
},
{
"Subject ID":"-",
"Sample ID":"C18-pos-HFD-Drug-417b",
"Factors":{"Treatment":"high fat diet+AC261073"},
"Additional sample data":{"RAW_FILE_NAME":"C18-pos-HFD-Drug-417b"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"At the termination of the treatments, after fasting overnight mice were sacrificed by cervical dislocation and liver samples were harvested for analysis.","SAMPLE_TYPE":"Liver"},

"TREATMENT":{"TREATMENT_SUMMARY":"Wild-type (wt) male C57BL/6 mice (6-7 weeks old) were maintained on either a standard laboratory chow (Con) diet with 13 % kcal fat (diet no. 5053, Pico Diet, St. Louis, MO), or a high fat diet (HFD) with 60% kcal from fat (diet no. 58125, Test Diet, Inc., St. Louis, MO) for 4 months. Two months after the start of the HFD, the mice were further split into three groups for 2 months to remain on (i) chow plus drinking water with 0.2 % DMSO; (ii) HFD plus drinking water containing 0.2 % DMSO; or (iii) HFD plus 3 mg AC261066 per 100 ml drinking water with 0.2 % DMSO."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"The snap frozen liver samples were incubated with 600 µL of 3 mM monobrombimane (MBB) in CH3OH:H2O (80:20) at -20°C for 2 h, followed by 1 h incubation at 0°C. This initial incubation was followed by tissue disruption using stainless steel beads in a TissueLyser (Qiagen) and an additional 30 min at -20°C. Extracts were centrifuged for 15 min at 13000 rpm to pellet insoluble material and supernatants were transferred to clean tubes. This extraction was repeated two additional times and all three supernatants were dried in a speed-vac (Savant) and stored at −80 °C until analysis."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"The mobile phase for RP separation consisted of 1 mM ammonium formate and 0.1% formic acid in H2O (solvent A) and 0.1% formic acid in CH3CN (solvent B). The gradient was as follows: 0–2 min, 1% B; 2– 20 min, to 50% B; 20–25 min, to 85% B; 25-30 min, to 99% B; 30.01-36 min, 1% B.","CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Agilent 1290 Infinity II","COLUMN_NAME":"Agilent Zorbax RRHD SB-C18 (100 x 2.1mm, 1.8um)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 6550 QTOF","INSTRUMENT_TYPE":"QTOF","MS_TYPE":"Other","ION_MODE":"NEGATIVE","MS_COMMENTS":"Agilent MassHunter Workstation"},

"MS_METABOLITE_DATA":{
"Units":"abundance",

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"Metabolites":[{"metabolite_name":"12-Hydroxydodecanoic Acid"},{"metabolite_name":"3-hydroxyisovaleric acid"},{"metabolite_name":"4-Hydroxybenzaldehyde"},{"metabolite_name":"4-Hydroxyphenyllactic Acid"},{"metabolite_name":"4-Ketoretinoic Acid"},{"metabolite_name":"7-methylguanine"},{"metabolite_name":"Acetoacetic acid"},{"metabolite_name":"Arachidic Acid"},{"metabolite_name":"Arachidonic acid (20:4 n-6)"},{"metabolite_name":"Azelaic Acid"},{"metabolite_name":"Behenic acid"},{"metabolite_name":"bilirubin"},{"metabolite_name":"C10 Ceramide"},{"metabolite_name":"C12 Ceramide"},{"metabolite_name":"Caffeic Acid"},{"metabolite_name":"Carnosic acid"},{"metabolite_name":"Cholesterol sulfate"},{"metabolite_name":"Cortisol"},{"metabolite_name":"cortisol 21-sulfate"},{"metabolite_name":"Dehydroisoandrosterone 3-sulfate"},{"metabolite_name":"Dioctyl Phthalate"},{"metabolite_name":"Docosahexaenoic Acid (22:6 n-3)"},{"metabolite_name":"Docosapentaenoic acid"},{"metabolite_name":"Eicosadienoic acid (20:2 n-6)"},{"metabolite_name":"Eicosapentaenoic acid (20:5 n-3)"},{"metabolite_name":"Eicosatrienoic acid (20:3 n-3)"},{"metabolite_name":"Eicosenoic acid"},{"metabolite_name":"Elaidic Acid"},{"metabolite_name":"Ergocalciferol"},{"metabolite_name":"Folic acid"},{"metabolite_name":"Glutaric Acid"},{"metabolite_name":"Linoleic acid"},{"metabolite_name":"Linolelaidic acid"},{"metabolite_name":"LysoPC(18:4)"},{"metabolite_name":"N-Acetylleucine"},{"metabolite_name":"Nonadecanoic acid"},{"metabolite_name":"Palmitic Acid"},{"metabolite_name":"Pentadecanoic acid"},{"metabolite_name":"Phenylacetic Acid"},{"metabolite_name":"Probucol"},{"metabolite_name":"Retinoic Acid"},{"metabolite_name":"SO32-"},{"metabolite_name":"Stearic Acid"},{"metabolite_name":"Stearidonic acid"},{"metabolite_name":"Vaccenic Acid"}]
}

}