{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001748","ANALYSIS_ID":"AN002845","VERSION":"1","CREATED_ON":"April 23, 2021, 9:08 am"},

"PROJECT":{"PROJECT_TITLE":"Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis","PROJECT_TYPE":"targeted metabolomics","PROJECT_SUMMARY":"Environmental factors, mucosal permeability and defective immunoregulation drive overactive immunity to a subset of resident intestinal bacteria that mediate multiple inflammatory conditions. GUT-103 and GUT-108, live biotherapeutic products rationally designed to complement missing or underrepresented functions in the dysbiotic microbiome of IBD patients, address upstream targets, rather than targeting a single cytokine to block downstream inflammation responses. GUT-103, composed of 17 strains that synergistically provide protective and sustained engraftment in the IBD inflammatory environment, prevented, and treated chronic immune-mediated colitis. Therapeutic application of GUT-108 reversed established colitis in a humanized chronic T cell-mediated mouse model. It decreased pathobionts while expanding resident protective bacteria; produced metabolites promoting mucosal healing and immunoregulatory responses; decreased inflammatory cytokines and Th-1 and Th-17 cells; and induced interleukin-10-producing colonic regulatory cells, and IL-10-independent homeostatic pathways. We propose GUT-108 for treating and preventing relapse for IBD and other inflammatory conditions characterized by unbalanced microbiota and mucosal permeability.","INSTITUTE":"University of North Carolina at Chapel Hill","DEPARTMENT":"UNC Departments of Medicine, Microbiology and Immunology, Center for Gastrointestinal Biology and Disease; UNC Department of Environmental Sciences and Engineering","LABORATORY":"R. Balfour Sartor Lab; Kun Lu Lab","LAST_NAME":"Lai","FIRST_NAME":"Yunjia","ADDRESS":"1104 MHRC, 135 Dauer Drive, NC","EMAIL":"lai7@live.unc.edu","PHONE":"919-480-5489","FUNDING_SOURCE":"Gusto Global LLC.; National Institute of Health (NIH) (grant no. P40OD010995; P30DK034987; P01DK094779); the Crohn’s and Colitis Foundation","PUBLICATIONS":"Nature Communications"},

"STUDY":{"STUDY_TITLE":"Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis","STUDY_TYPE":"Targeted metabolomics","STUDY_SUMMARY":"GUT103 and GUT108, live biotherapeutic products rationally designed to complement missing or underrepresented functions in the dysbiotic microbiome of IBD patients; they address upstream targets, rather than targeting a single cytokine to block downstream inflammation responses. Systematic colonization experiments in colitis mouse models were performed to test their therapeutic effects. Targeted fecal metabolomics data uploaded here of bile acids, short-chain fatty acids, and tryptophan metabolites provides a unique metabolome perspective for evaluation of the therapeutic potential of GUT103 and GUT108.","INSTITUTE":"University of North Carolina at Chapel Hill","LABORATORY":"Gusto Global LLC.","LAST_NAME":"Lai","FIRST_NAME":"Yunjia","ADDRESS":"1104 MHRC, 135 Dauer Drive, Chapel Hill, NC 27599, USA","EMAIL":"lai7@live.unc.edu","PHONE":"+1 919-480-5489","NUM_GROUPS":"12","PUBLICATIONS":"Nature Communications"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090","GENOTYPE_STRAIN":"GF 129SvEv background IL-10-deficient mice (Il10-/-); Il10-eGFP-reporter (Il10+/eGFP) mice (on a C57BL/6J background)","AGE_OR_AGE_RANGE":"8-12 week old","ANIMAL_ANIMAL_SUPPLIER":"8-12 week-age GF 129SvEv background IL-10-deficient mice (Il10-/-) were obtained from University of North Carolina National Gnotobiotic Rodent Resource Center; Il10-eGFP-reporter (Il10+/eGFP) mice on a C57BL/6J background mice were originally provided by Dr. C. L. Karp (Global Health, Bill & Melinda Gates Foundation, USA)","ANIMAL_HOUSING":"Germ-free and gnotobiotic conditions at National Gnotobiotic Rodent Resource Center, University of North Carolina"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_1_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_1_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_2_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_2_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_3_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_3_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_4_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_4_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_5_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_5_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_6_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_6_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_7_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_7_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_8_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_8_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_9_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_9_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_10_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_10_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_11_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_11_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_12_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_12_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_13_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_13_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_14_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_14_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_15_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_15_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_16_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_16_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_17_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_17_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_18_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_18_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_19_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_19_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_20_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_20_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_21_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_21_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_22_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_22_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_23_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_23_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_24_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_24_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_25_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_25_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_26_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_26_GUT103"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_27_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_27_GUT103"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_28_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_28_GUT103"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_29_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_29_GUT103"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"bileacid_Exp1_30_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp1_30_GUT103"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_1_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_1_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_2_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_2_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_3_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_3_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_4_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_4_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_5_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_5_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_6_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_6_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_7_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_7_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_8_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_8_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_9_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_9_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_10_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_10_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_11_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_11_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_12_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_12_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_13_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_13_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_14_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_14_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_15_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_15_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_16_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_16_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_17_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_17_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_18_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_18_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_19_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_19_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_20_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_20_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_21_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_21_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_22_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_22_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_1_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_1_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_2_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_2_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_3_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_3_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_4_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_4_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_5_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_5_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_6_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_6_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_7_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_7_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_8_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_8_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_9_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_9_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_10_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_10_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_11_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_11_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_12_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_12_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_13_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_13_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_14_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_14_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_15_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_15_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_16_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_16_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_17_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_17_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_18_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_18_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_19_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_19_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_20_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_20_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_21_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_21_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp2_22_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp2_22_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_1_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_1_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_3_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_3_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_4_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_4_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_5_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_5_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_6_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_6_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_14_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_14_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_15_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_15_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_17_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_17_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_18_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_18_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_19_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_19_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_20_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_20_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_1_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_1_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_3_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_3_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_4_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_4_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_5_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_5_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_6_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_6_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_14_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_14_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_15_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_15_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_17_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_17_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_18_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_18_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_19_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_19_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"bileacid_Exp3_20_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"bile acids","RAW_FILE_NAME":"bileacid_Exp3_20_GUT108_week2"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_1_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_1_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_2_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_2_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_4_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_4_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_5_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_5_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_6_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_6_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_7_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_7_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_8_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_8_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_9_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_9_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_10_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_10_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_11_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_11_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_12_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_12_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_13_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_13_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_14_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_14_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_15_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_15_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_16_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_16_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_17_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_17_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_18_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_18_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_19_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_19_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_20_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_20_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_21_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_21_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_22_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_22_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_23_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_23_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_24_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_24_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_25_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_25_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_26_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_26_GUT103"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_27_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_27_GUT103"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_28_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_28_GUT103"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_29_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_29_GUT103"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"scfa_Exp1_30_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp1_30_GUT103"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_1_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_1_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_2_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_2_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_3_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_3_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_4_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_4_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_5_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_5_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_6_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_6_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_7_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_7_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_8_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_8_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_9_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_9_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_10_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_10_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_11_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_11_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_12_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_12_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_13_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_13_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_14_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_14_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_15_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_15_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_16_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_16_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_17_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_17_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_18_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_18_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_19_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_19_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_20_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_20_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_21_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_21_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_22_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_22_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_1_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_1_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_2_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_2_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_3_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_3_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_4_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_4_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_5_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_5_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_6_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_6_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_7_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_7_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_8_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_8_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_9_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_9_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_10_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_10_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_11_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_11_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_12_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_12_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_13_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_13_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_14_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_14_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_15_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_15_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_16_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_16_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_17_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_17_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_18_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_18_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_19_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_19_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_20_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_20_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_21_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_21_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp2_22_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp2_22_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_1_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_1_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_3_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_3_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_4_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_4_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_5_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_5_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_6_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_6_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_14_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_14_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_15_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_15_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_17_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_17_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_18_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_18_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_19_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_19_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_20_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_20_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_1_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_1_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_3_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_3_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_4_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_4_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_5_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_5_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_6_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_6_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_14_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_14_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_15_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_15_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_17_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_17_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_18_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_18_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_19_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_19_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"scfa_Exp3_20_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"SCFAs","RAW_FILE_NAME":"scfa_Exp3_20_GUT108_week2"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_1_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_1_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_2_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_2_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_3_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_3_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_4_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_4_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_5_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_5_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_6_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_6_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_7_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_7_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_8_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_8_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_9_EER",
"Factors":{"Treatment":"EER bacterial strains"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_9_EER"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_10_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_10_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_11_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_11_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_12_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_12_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_13_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_13_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_14_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_14_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_15_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_15_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_16_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_16_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_17_Therapy",
"Factors":{"Treatment":"EER plus GUT-103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_17_Therapy"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_18_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_18_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_19_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_19_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_20_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_20_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_21_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_21_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_22_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_22_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_23_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_23_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_24_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_24_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_25_Prevention",
"Factors":{"Treatment":"GUT-103 plus EER"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_25_Prevention"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_26_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_26_GUT103"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_27_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_27_GUT103"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_28_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_28_GUT103"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_29_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_29_GUT103"}
},
{
"Subject ID":"Il10+/eGFP",
"Sample ID":"trps_Exp1_30_GUT103",
"Factors":{"Treatment":"GUT103"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp1_30_GUT103"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_1_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_1_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_2_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_2_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_3_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_3_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_4_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_4_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_5_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_5_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_6_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_6_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_7_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_7_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_8_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_8_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_9_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_9_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_10_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_10_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_11_Hu+PBS_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_11_Hu+PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_12_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_12_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_13_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_13_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_14_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_14_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_15_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_15_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_16_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_16_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_17_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_17_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_18_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_18_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_19_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_19_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_20_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_20_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_21_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_21_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_22_Hu+GUT108_week2",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_22_Hu+GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_1_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_1_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_2_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_2_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_3_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_3_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_4_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_4_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_5_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_5_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_6_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_6_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_7_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_7_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_8_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_8_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_9_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_9_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_10_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_10_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_11_Hu+PBS_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_11_Hu+PBS_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_12_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_12_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_13_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_13_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_14_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_14_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_15_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_15_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_16_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_16_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_17_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_17_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_18_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_18_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_19_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_19_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_20_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_20_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_21_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_21_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp2_22_Hu+GUT108_week4",
"Factors":{"Treatment":"After 2 wk GUT/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp2_22_Hu+GUT108_week4"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_1_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_1_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_3_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_3_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_4_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_4_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_5_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_5_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_6_PBS_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_6_PBS_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_14_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_14_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_15_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_15_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_17_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_17_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_18_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_18_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_19_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_19_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_20_GUT108_week0",
"Factors":{"Treatment":"Before GUT108/PBS therapy (baseline)"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_20_GUT108_week0"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_1_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_1_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_3_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_3_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_4_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_4_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_5_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_5_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_6_PBS_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_6_PBS_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_14_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_14_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_15_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_15_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_17_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_17_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_18_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_18_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_19_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_19_GUT108_week2"}
},
{
"Subject ID":"Il10-/-",
"Sample ID":"trps_Exp3_20_GUT108_week2",
"Factors":{"Treatment":"After GUT108/PBS therapy"},
"Additional sample data":{"Target of analysis":"tryptophan metabolites","RAW_FILE_NAME":"trps_Exp3_20_GUT108_week2"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"For samples for targeted metabolomics analysis, mouse cecal content and/or feces were collected.","COLLECTION_PROTOCOL_ID":"University of North Carolina at Chapel Hill Institutional Animal Care and Use Committee (18-266.0-B)","SAMPLE_TYPE":"Feces","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"For treatment 200 µl of diluted human donor stool was applied by oral gavage on day 1 to Il10-/- mice. The stool was derived from a single healthy donor, Donor-Y, and was previously found to induce moderate to severe colitis in Il10-/- mice. One gram stool was diluted 100- fold with anaerobic PBS, and vigorously mixed for 5 minutes under anaerobic conditions. For application of GUT-103 and GUT-108, 300µl resuspended strain mixture in anaerobic PBS was applied per mouse by oral gavage. GUT-103 and GUT-108 strains were grown individually, subsequently mixed to equal concentrations (cfu/ml), and provided at a dose of 2.0x10+7 cfu/strain in a total volume of 300 µl. The strain mixture was provided four times via oral gavage on days 15, 17, 22 and 25 (Il10-/- mice) or on days 1, 3, 8 and 11 (Il10+/eGFP mice)."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Bile acids, SCFAs, and tryptophan metabolites were extracted (with careful cleanup or derivatization procedures whenever necessary) and analyzed using mass spectrometry-based platforms.","SAMPLEPREP_PROTOCOL_FILENAME":"Protocols.pdf","PROCESSING_STORAGE_CONDITIONS":"On ice","EXTRACTION_METHOD":"Bile acid: SPE and LLE; SCFA: alkaline aqueous extraction; tryptophan metabolites: 1:1 MeOH:Water LLE","EXTRACT_CLEANUP":"For Bile acids, C18 solid-phase extraction cleanup and concentration was used.","EXTRACT_STORAGE":"-80℃","SAMPLE_DERIVATIZATION":"For SCFAs, propyl chloroformate derivatization was performed."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Generic DB-5ms GC capillary column for analysis of SCFA derivatives.","CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"Agilent 7820A","COLUMN_NAME":"Agilent DB5-MS (30m x 0.25mm, 0.25um)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 5977B","INSTRUMENT_TYPE":"Single quadrupole","MS_TYPE":"EI","ION_MODE":"POSITIVE","MS_COMMENTS":"fullscan data with scan range of m/z 30-600; Peak integration was performed in MassHunter Qual."},

"MS_METABOLITE_DATA":{
"Units":"mg/g",

"Data":[{"Metabolite":"propionic acid","scfa_Exp1_1_EER":"0","scfa_Exp1_2_EER":"0.286","scfa_Exp1_4_EER":"0.249","scfa_Exp1_5_EER":"0.223","scfa_Exp1_6_EER":"0.133","scfa_Exp1_7_EER":"0.196","scfa_Exp1_8_EER":"0.272","scfa_Exp1_9_EER":"0.266","scfa_Exp1_10_Therapy":"0.469","scfa_Exp1_11_Therapy":"0.248","scfa_Exp1_12_Therapy":"0.366","scfa_Exp1_13_Therapy":"0.465","scfa_Exp1_14_Therapy":"0.31","scfa_Exp1_15_Therapy":"0.398","scfa_Exp1_16_Therapy":"0.469","scfa_Exp1_17_Therapy":"0.555","scfa_Exp1_18_Prevention":"0.431","scfa_Exp1_19_Prevention":"0.418","scfa_Exp1_20_Prevention":"0.455","scfa_Exp1_21_Prevention":"0.623","scfa_Exp1_22_Prevention":"0.499","scfa_Exp1_23_Prevention":"0.587","scfa_Exp1_24_Prevention":"0.697","scfa_Exp1_25_Prevention":"0","scfa_Exp1_26_GUT103":"0.565","scfa_Exp1_27_GUT103":"0.518","scfa_Exp1_28_GUT103":"0.45","scfa_Exp1_29_GUT103":"0.764","scfa_Exp1_30_GUT103":"0.645","scfa_Exp2_1_Hu+PBS_week2":"0.588367081","scfa_Exp2_2_Hu+PBS_week2":"0.384565256","scfa_Exp2_3_Hu+PBS_week2":"0.543307895","scfa_Exp2_4_Hu+PBS_week2":"0.512078999","scfa_Exp2_5_Hu+PBS_week2":"0.26084869","scfa_Exp2_6_Hu+PBS_week2":"0.421805592","scfa_Exp2_7_Hu+PBS_week2":"0.489997758","scfa_Exp2_8_Hu+PBS_week2":"0.426019421","scfa_Exp2_9_Hu+PBS_week2":"0.698119132","scfa_Exp2_10_Hu+PBS_week2":"0.514521748","scfa_Exp2_11_Hu+PBS_week2":"0.618847092","scfa_Exp2_12_Hu+GUT108_week2":"0.436382013","scfa_Exp2_13_Hu+GUT108_week2":"0.407112174","scfa_Exp2_14_Hu+GUT108_week2":"0.394507401","scfa_Exp2_15_Hu+GUT108_week2":"0.500516645","scfa_Exp2_16_Hu+GUT108_week2":"0.428707505","scfa_Exp2_17_Hu+GUT108_week2":"0.528570265","scfa_Exp2_18_Hu+GUT108_week2":"0.316501735","scfa_Exp2_19_Hu+GUT108_week2":"0.342707576","scfa_Exp2_20_Hu+GUT108_week2":"0.88467411","scfa_Exp2_21_Hu+GUT108_week2":"0.398854487","scfa_Exp2_22_Hu+GUT108_week2":"0.376588311","scfa_Exp2_1_Hu+PBS_week4":"0.907748393","scfa_Exp2_2_Hu+PBS_week4":"1.054834646","scfa_Exp2_3_Hu+PBS_week4":"0.344681608","scfa_Exp2_4_Hu+PBS_week4":"0.98684684","scfa_Exp2_5_Hu+PBS_week4":"0.618308102","scfa_Exp2_6_Hu+PBS_week4":"0.2835422","scfa_Exp2_7_Hu+PBS_week4":"0.512275895","scfa_Exp2_8_Hu+PBS_week4":"0.924360294","scfa_Exp2_9_Hu+PBS_week4":"1.482018179","scfa_Exp2_10_Hu+PBS_week4":"0.522742482","scfa_Exp2_11_Hu+PBS_week4":"0.983334458","scfa_Exp2_12_Hu+GUT108_week4":"1.074027249","scfa_Exp2_13_Hu+GUT108_week4":"0.854317611","scfa_Exp2_14_Hu+GUT108_week4":"1.165445688","scfa_Exp2_15_Hu+GUT108_week4":"0.756129903","scfa_Exp2_16_Hu+GUT108_week4":"1.164902923","scfa_Exp2_17_Hu+GUT108_week4":"1.189441055","scfa_Exp2_18_Hu+GUT108_week4":"0.826175788","scfa_Exp2_19_Hu+GUT108_week4":"1.156902376","scfa_Exp2_20_Hu+GUT108_week4":"1.241702627","scfa_Exp2_21_Hu+GUT108_week4":"1.040988054","scfa_Exp2_22_Hu+GUT108_week4":"0.779835667","scfa_Exp3_1_PBS_week0":"0.14518","scfa_Exp3_3_PBS_week0":"0.12522","scfa_Exp3_4_PBS_week0":"0.09812","scfa_Exp3_5_PBS_week0":"0.13027","scfa_Exp3_6_PBS_week0":"0.12852","scfa_Exp3_14_GUT108_week0":"0.12908","scfa_Exp3_15_GUT108_week0":"0.1101","scfa_Exp3_17_GUT108_week0":"0.12688","scfa_Exp3_18_GUT108_week0":"0.11506","scfa_Exp3_19_GUT108_week0":"0.11134","scfa_Exp3_20_GUT108_week0":"0.10914","scfa_Exp3_1_PBS_week2":"0.10674","scfa_Exp3_3_PBS_week2":"0.08525","scfa_Exp3_4_PBS_week2":"0.09076","scfa_Exp3_5_PBS_week2":"0.14","scfa_Exp3_6_PBS_week2":"0.10366","scfa_Exp3_14_GUT108_week2":"0.54582","scfa_Exp3_15_GUT108_week2":"0.55492","scfa_Exp3_17_GUT108_week2":"0.72396","scfa_Exp3_18_GUT108_week2":"0.73362","scfa_Exp3_19_GUT108_week2":"0.57168","scfa_Exp3_20_GUT108_week2":"0.5853"},{"Metabolite":"butyric acid","scfa_Exp1_1_EER":"0.002","scfa_Exp1_2_EER":"0.002","scfa_Exp1_4_EER":"0.004","scfa_Exp1_5_EER":"0.003","scfa_Exp1_6_EER":"0","scfa_Exp1_7_EER":"0.003","scfa_Exp1_8_EER":"0.001","scfa_Exp1_9_EER":"0","scfa_Exp1_10_Therapy":"0.035","scfa_Exp1_11_Therapy":"0.043","scfa_Exp1_12_Therapy":"0.031","scfa_Exp1_13_Therapy":"0.052","scfa_Exp1_14_Therapy":"0.046","scfa_Exp1_15_Therapy":"0.04","scfa_Exp1_16_Therapy":"0.031","scfa_Exp1_17_Therapy":"0.037","scfa_Exp1_18_Prevention":"0.056","scfa_Exp1_19_Prevention":"0.044","scfa_Exp1_20_Prevention":"0.074","scfa_Exp1_21_Prevention":"0.076","scfa_Exp1_22_Prevention":"0.043","scfa_Exp1_23_Prevention":"0.054","scfa_Exp1_24_Prevention":"0.063","scfa_Exp1_25_Prevention":"0","scfa_Exp1_26_GUT103":"0.04","scfa_Exp1_27_GUT103":"0.033","scfa_Exp1_28_GUT103":"0.041","scfa_Exp1_29_GUT103":"0.051","scfa_Exp1_30_GUT103":"0.033","scfa_Exp2_1_Hu+PBS_week2":"0.065638479","scfa_Exp2_2_Hu+PBS_week2":"0.200507744","scfa_Exp2_3_Hu+PBS_week2":"0.129626819","scfa_Exp2_4_Hu+PBS_week2":"0.08028606","scfa_Exp2_5_Hu+PBS_week2":"0.173755132","scfa_Exp2_6_Hu+PBS_week2":"0.035067598","scfa_Exp2_7_Hu+PBS_week2":"0.132406584","scfa_Exp2_8_Hu+PBS_week2":"0.065889218","scfa_Exp2_9_Hu+PBS_week2":"0.110427111","scfa_Exp2_10_Hu+PBS_week2":"0.16838814","scfa_Exp2_11_Hu+PBS_week2":"0.175137161","scfa_Exp2_12_Hu+GUT108_week2":"0.280428687","scfa_Exp2_13_Hu+GUT108_week2":"0.143289102","scfa_Exp2_14_Hu+GUT108_week2":"0.146937237","scfa_Exp2_15_Hu+GUT108_week2":"0.039510957","scfa_Exp2_16_Hu+GUT108_week2":"0.115385179","scfa_Exp2_17_Hu+GUT108_week2":"0.286490134","scfa_Exp2_18_Hu+GUT108_week2":"0.157136364","scfa_Exp2_19_Hu+GUT108_week2":"0.352055843","scfa_Exp2_20_Hu+GUT108_week2":"0.106476238","scfa_Exp2_21_Hu+GUT108_week2":"0.063637421","scfa_Exp2_22_Hu+GUT108_week2":"0.087559784","scfa_Exp2_1_Hu+PBS_week4":"0.159468053","scfa_Exp2_2_Hu+PBS_week4":"0.188771612","scfa_Exp2_3_Hu+PBS_week4":"0.015220889","scfa_Exp2_4_Hu+PBS_week4":"0.212878689","scfa_Exp2_5_Hu+PBS_week4":"0.284037959","scfa_Exp2_6_Hu+PBS_week4":"0.065304955","scfa_Exp2_7_Hu+PBS_week4":"0.131717298","scfa_Exp2_8_Hu+PBS_week4":"0.098511125","scfa_Exp2_9_Hu+PBS_week4":"0.194552448","scfa_Exp2_10_Hu+PBS_week4":"0.141685363","scfa_Exp2_11_Hu+PBS_week4":"0.147247887","scfa_Exp2_12_Hu+GUT108_week4":"0.115825165","scfa_Exp2_13_Hu+GUT108_week4":"0.217335834","scfa_Exp2_14_Hu+GUT108_week4":"0.159169949","scfa_Exp2_15_Hu+GUT108_week4":"0.073092219","scfa_Exp2_16_Hu+GUT108_week4":"0.14359601","scfa_Exp2_17_Hu+GUT108_week4":"0.105975584","scfa_Exp2_18_Hu+GUT108_week4":"0.081002077","scfa_Exp2_19_Hu+GUT108_week4":"0.248160255","scfa_Exp2_20_Hu+GUT108_week4":"0.193697501","scfa_Exp2_21_Hu+GUT108_week4":"0.134085295","scfa_Exp2_22_Hu+GUT108_week4":"0.082759544","scfa_Exp3_1_PBS_week0":"0.00151","scfa_Exp3_3_PBS_week0":"0.00109","scfa_Exp3_4_PBS_week0":"0.0005","scfa_Exp3_5_PBS_week0":"0.00089","scfa_Exp3_6_PBS_week0":"0.00083","scfa_Exp3_14_GUT108_week0":"0.00145","scfa_Exp3_15_GUT108_week0":"0.00185","scfa_Exp3_17_GUT108_week0":"0","scfa_Exp3_18_GUT108_week0":"0.00086","scfa_Exp3_19_GUT108_week0":"0","scfa_Exp3_20_GUT108_week0":"0.00114","scfa_Exp3_1_PBS_week2":"0.00022","scfa_Exp3_3_PBS_week2":"0.00024","scfa_Exp3_4_PBS_week2":"0","scfa_Exp3_5_PBS_week2":"0.00211","scfa_Exp3_6_PBS_week2":"0.00087","scfa_Exp3_14_GUT108_week2":"0.01246","scfa_Exp3_15_GUT108_week2":"0.01984","scfa_Exp3_17_GUT108_week2":"0.02147","scfa_Exp3_18_GUT108_week2":"0.01918","scfa_Exp3_19_GUT108_week2":"0.03233","scfa_Exp3_20_GUT108_week2":"0.02574"}],

"Metabolites":[{"Metabolite":"propionic acid","retention time":"4.06","quantified m/z":"75","PubChem_CID":"1032","KEGG_ID":"C00163"},{"Metabolite":"butyric acid","retention time":"5.77","quantified m/z":"71","PubChem_CID":"264","KEGG_ID":"C00264"}]
}

}