{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001850","ANALYSIS_ID":"AN002997","VERSION":"1","CREATED_ON":"June 29, 2021, 5:37 am"},

"PROJECT":{"PROJECT_TITLE":"NonTargeted LC-MS-based metabolomics analysis for both whole cell and mitochondria metabolites to gain an insight into the role of Tug1/PGC1 axis on metabolite profiles in podocytes","PROJECT_TYPE":"Biomarker","PROJECT_SUMMARY":"We found that double mutant Tug1-KD/Pgc1-OE rescued the effects of Tug1-KD on basal, maximal, and spare capacity respiration rates in podocytes. Therefore we employed an unbiased LCMS based metabolomics analysis or both whole cell and mitochondria metabolites to gain an insight into the role of Tug1/PGC1 on metabolite profiles in podocytes.","INSTITUTE":"University of Texas MD Anderson Cancer Center","DEPARTMENT":"Nephrology","LAST_NAME":"Danesh","FIRST_NAME":"Farhad","ADDRESS":"1515 Holcombe Blvd, Houston, TX77030","EMAIL":"fdanesh@mdanderson.org","PHONE":"7135634498"},

"STUDY":{"STUDY_TITLE":"Unbiased LC-MS-based metabolomics analysis for both whole cell and mitochondria metabolites to gain an insight into the role of Tug1/PGC1 axis on metabolite profiles in podocytes","STUDY_SUMMARY":"unbiased LC-MS-based metabolomics analysis for both whole cell and mitochondria metabolites to gain an insight into the role of Tug1/PGC1 axis on metabolite profiles in podocytes","INSTITUTE":"University of Texas MD Anderson Cancer Center","LAST_NAME":"Danesh","FIRST_NAME":"Farhad","ADDRESS":"1515 Holcombe Blvd, Houston ,TX77030","EMAIL":"fdanesh@mdanderson.org","PHONE":"7135634498","NUM_GROUPS":"3"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"PLKO_1_Hilic",
"Factors":{"Treatment":"PLKO"},
"Additional sample data":{"RAW_FILE_NAME":"210111_AA_PLKO_1"}
},
{
"Subject ID":"-",
"Sample ID":"PLKO_2_Hilic",
"Factors":{"Treatment":"PLKO"},
"Additional sample data":{"RAW_FILE_NAME":"210111_AA_PLKO_2"}
},
{
"Subject ID":"-",
"Sample ID":"PLKO_3_Hilic",
"Factors":{"Treatment":"PLKO"},
"Additional sample data":{"RAW_FILE_NAME":"210111_AA_PLKO_3"}
},
{
"Subject ID":"-",
"Sample ID":"Tugl-KD_1_Hilic",
"Factors":{"Treatment":"Tug1-KD"},
"Additional sample data":{"RAW_FILE_NAME":"210111_AA_Tugl-KD_1"}
},
{
"Subject ID":"-",
"Sample ID":"Tugl-KD_2_Hilic",
"Factors":{"Treatment":"Tug1-KD"},
"Additional sample data":{"RAW_FILE_NAME":"210111_AA_Tugl-KD_2"}
},
{
"Subject ID":"-",
"Sample ID":"Tugl-KD_3_Hilic",
"Factors":{"Treatment":"Tug1-KD"},
"Additional sample data":{"RAW_FILE_NAME":"210111_AA_Tugl-KD_3"}
},
{
"Subject ID":"-",
"Sample ID":"Tugl-KD_PGCOE_1_Hilic",
"Factors":{"Treatment":"PGCOE"},
"Additional sample data":{"RAW_FILE_NAME":"210111_AA_Tugl-KD_PGCOE_1"}
},
{
"Subject ID":"-",
"Sample ID":"Tugl-KD_PGCOE_2_Hilic",
"Factors":{"Treatment":"PGCOE"},
"Additional sample data":{"RAW_FILE_NAME":"210111_AA_Tugl-KD_PGCOE_2"}
},
{
"Subject ID":"-",
"Sample ID":"Tugl-KD_PGCOE_3_Hilic",
"Factors":{"Treatment":"PGCOE"},
"Additional sample data":{"RAW_FILE_NAME":"210111_AA_Tugl-KD_PGCOE_3"}
},
{
"Subject ID":"-",
"Sample ID":"PLKO_1_IC",
"Factors":{"Treatment":"PLKO"},
"Additional sample data":{"RAW_FILE_NAME":"210111_Cells_PLKO_1"}
},
{
"Subject ID":"-",
"Sample ID":"PLKO_2_IC",
"Factors":{"Treatment":"PLKO"},
"Additional sample data":{"RAW_FILE_NAME":"210111_Cells_PLKO_2"}
},
{
"Subject ID":"-",
"Sample ID":"PLKO_3_IC",
"Factors":{"Treatment":"PLKO"},
"Additional sample data":{"RAW_FILE_NAME":"210111_Cells_PLKO_3"}
},
{
"Subject ID":"-",
"Sample ID":"Tugl-KD_1_IC",
"Factors":{"Treatment":"Tug1-KD"},
"Additional sample data":{"RAW_FILE_NAME":"210111_Cells_Tug1-KD_1"}
},
{
"Subject ID":"-",
"Sample ID":"Tugl-KD_2_IC",
"Factors":{"Treatment":"Tug1-KD"},
"Additional sample data":{"RAW_FILE_NAME":"210111_Cells_Tug1-KD_2"}
},
{
"Subject ID":"-",
"Sample ID":"Tugl-KD_3_IC",
"Factors":{"Treatment":"Tug1-KD"},
"Additional sample data":{"RAW_FILE_NAME":"210111_Cells_Tug1-KD_3"}
},
{
"Subject ID":"-",
"Sample ID":"Tugl-KD_PGCOE_1_IC",
"Factors":{"Treatment":"PGCOE"},
"Additional sample data":{"RAW_FILE_NAME":"210111_Clees_Tug1-KD_PGCOE_1"}
},
{
"Subject ID":"-",
"Sample ID":"Tugl-KD_PGCOE_2_IC",
"Factors":{"Treatment":"PGCOE"},
"Additional sample data":{"RAW_FILE_NAME":"210111_Clees_Tug1-KD_PGCOE_2"}
},
{
"Subject ID":"-",
"Sample ID":"Tugl-KD_PGCOE_3_IC",
"Factors":{"Treatment":"PGCOE"},
"Additional sample data":{"RAW_FILE_NAME":"210111_Clees_Tug1-KD_PGCOE_3"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Briefly, podocytes were cultured on BD BioCoat Collagen I plates (BD Biosciences, San Jose, CA) at 33°C in RPMI 1640 complete media with 20 U/ml mouse recombinant IFN-g (Thermo Fisher, Carlsbad, CA). To induce differentiation, we cultured podocytes in DMEM (5.5mM glucose and 5% FBS) at 37°C without IFN-g for 10-12 days. To rescue the expression of PGC1-a in stable Tug1-knockdown CRISPR clone (Tug1-KD)(Long et al., 2016), CMV enhancer/promoter-driven mouse Pgc1-a cDNA (Addgene, Watertown, MA) was inserted into vector Zeo-pT-MCS-GFP-T2A-Puro(Long et al., 2020), a modified PiggyBac transposon system, selected with 1ug/ml puromycin and sorted by GFP, to generate Tug1-KD/Pgc1-OE. We isolated kidney podocytes by positive selection with biotin-labelled Kirrel3 and Podocalyxin antibodies (2.5 μg/antibody/mouse, R&D Systems, Minneapolis, MN) followed by Streptavidin M-280 Dynabeads as previously described (Badal et al., 2016).","SAMPLE_TYPE":"Epithelial cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"we cultured podocytes in DMEM (5.5mM glucose and 5% FBS) at 37°C without IFN-g for 10-12 days. To rescue the expression of PGC1-a in stable Tug1-knockdown CRISPR clone (Tug1-KD)(Long et al., 2016), CMV enhancer/promoter-driven mouse Pgc1-a cDNA (Addgene, Watertown, MA) was inserted into vector Zeo-pT-MCS-GFP-T2A-Puro(Long et al., 2020), a modified PiggyBac transposon system, selected with 1ug/ml puromycin and sorted by GFP, to generate Tug1-KD/Pgc1-OE."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Metabolites from cell samples (in triplicates) grown on 10cm dishes were extracted with ice-cold 80% methanol. After centrifugation, extracts in supernatants were dried by evaporation under nitrogen.","PROCESSING_STORAGE_CONDITIONS":"On ice","EXTRACT_STORAGE":"-80℃"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"ion chromatography (IC)-MS","CHROMATOGRAPHY_TYPE":"Other","INSTRUMENT_NAME":"Thermo Dionex ICS-5000+","COLUMN_NAME":"Dionex IonPac AS11"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS","LABORATORY_NAME":"MD Anderson Metabolomics Core","OPERATOR_NAME":"Lin Tan"},

"MS":{"INSTRUMENT_NAME":"Thermo Fusion Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"NEGATIVE","MS_COMMENTS":"Data were acquired using a Thermo Orbitrap Fusion Tribrid Mass Spectrometer under ESI negative ionization mode. Raw data files were imported to Thermo Trace Finder software for final analysis. The relative abundance of each metabolite was normalized by DNA concentrations."},

"MS_METABOLITE_DATA":{
"Units":"AUC/ngDNA",

"Data":[{"Metabolite":"(2R)-2-Hydroxy-3-(phosphonatooxy)propanoate","PLKO_1_IC":"1.15e-03","PLKO_2_IC":"5.55e-04","PLKO_3_IC":"2.94e-04","Tugl-KD_1_IC":"7.34e-04","Tugl-KD_2_IC":"3.25e-04","Tugl-KD_3_IC":"5.10e-04","Tugl-KD_PGCOE_1_IC":"3.36e-03","Tugl-KD_PGCOE_2_IC":"5.75e-04","Tugl-KD_PGCOE_3_IC":"7.43e-04"},{"Metabolite":"2-Aminomuconic acid semialdehyde","PLKO_1_IC":"1.52e-03","PLKO_2_IC":"1.06e-03","PLKO_3_IC":"8.04e-04","Tugl-KD_1_IC":"2.10e-03","Tugl-KD_2_IC":"1.55e-03","Tugl-KD_3_IC":"1.17e-03","Tugl-KD_PGCOE_1_IC":"1.70e-03","Tugl-KD_PGCOE_2_IC":"1.09e-03","Tugl-KD_PGCOE_3_IC":"1.19e-03"},{"Metabolite":"2-Hydroxyadipic acid","PLKO_1_IC":"1.88e-04","PLKO_2_IC":"1.54e-04","PLKO_3_IC":"1.17e-04","Tugl-KD_1_IC":"2.60e-04","Tugl-KD_2_IC":"2.20e-04","Tugl-KD_3_IC":"1.86e-04","Tugl-KD_PGCOE_1_IC":"7.20e-04","Tugl-KD_PGCOE_2_IC":"4.74e-04","Tugl-KD_PGCOE_3_IC":"4.64e-04"},{"Metabolite":"2-Hydroxybutyric acid","PLKO_1_IC":"7.07e-05","PLKO_2_IC":"8.76e-05","PLKO_3_IC":"6.00e-05","Tugl-KD_1_IC":"1.05e-04","Tugl-KD_2_IC":"7.03e-05","Tugl-KD_3_IC":"6.64e-05","Tugl-KD_PGCOE_1_IC":"1.07e-04","Tugl-KD_PGCOE_2_IC":"9.52e-05","Tugl-KD_PGCOE_3_IC":"5.70e-05"},{"Metabolite":"2-Hydroxyglutarate","PLKO_1_IC":"1.14e-03","PLKO_2_IC":"9.46e-04","PLKO_3_IC":"8.60e-04","Tugl-KD_1_IC":"1.83e-03","Tugl-KD_2_IC":"1.63e-03","Tugl-KD_3_IC":"1.38e-03","Tugl-KD_PGCOE_1_IC":"1.67e-03","Tugl-KD_PGCOE_2_IC":"1.22e-03","Tugl-KD_PGCOE_3_IC":"1.26e-03"},{"Metabolite":"2-Methylglutaric acid","PLKO_1_IC":"6.51e-05","PLKO_2_IC":"1.07e-04","PLKO_3_IC":"7.90e-05","Tugl-KD_1_IC":"9.11e-05","Tugl-KD_2_IC":"8.94e-05","Tugl-KD_3_IC":"1.23e-04","Tugl-KD_PGCOE_1_IC":"1.25e-04","Tugl-KD_PGCOE_2_IC":"1.41e-04","Tugl-KD_PGCOE_3_IC":"8.45e-05"},{"Metabolite":"2-Phospho-D-glyceric acid","PLKO_1_IC":"1.13e-03","PLKO_2_IC":"5.51e-04","PLKO_3_IC":"2.93e-04","Tugl-KD_1_IC":"7.30e-04","Tugl-KD_2_IC":"3.24e-04","Tugl-KD_3_IC":"5.06e-04","Tugl-KD_PGCOE_1_IC":"3.34e-03","Tugl-KD_PGCOE_2_IC":"5.61e-04","Tugl-KD_PGCOE_3_IC":"7.32e-04"},{"Metabolite":"2-Propylglutaric acid","PLKO_1_IC":"5.24e-05","PLKO_2_IC":"8.32e-05","PLKO_3_IC":"6.07e-05","Tugl-KD_1_IC":"6.15e-05","Tugl-KD_2_IC":"5.31e-05","Tugl-KD_3_IC":"7.35e-05","Tugl-KD_PGCOE_1_IC":"7.84e-05","Tugl-KD_PGCOE_2_IC":"7.94e-05","Tugl-KD_PGCOE_3_IC":"6.72e-05"},{"Metabolite":"3-Dehydro-L-gulonate","PLKO_1_IC":"4.83e-05","PLKO_2_IC":"5.83e-05","PLKO_3_IC":"4.36e-05","Tugl-KD_1_IC":"4.52e-05","Tugl-KD_2_IC":"5.14e-05","Tugl-KD_3_IC":"4.31e-05","Tugl-KD_PGCOE_1_IC":"7.36e-05","Tugl-KD_PGCOE_2_IC":"2.44e-05","Tugl-KD_PGCOE_3_IC":"5.20e-05"},{"Metabolite":"3-Hydroxybutyric acid","PLKO_1_IC":"7.07e-05","PLKO_2_IC":"8.76e-05","PLKO_3_IC":"6.00e-05","Tugl-KD_1_IC":"1.05e-04","Tugl-KD_2_IC":"7.03e-05","Tugl-KD_3_IC":"6.64e-05","Tugl-KD_PGCOE_1_IC":"1.07e-04","Tugl-KD_PGCOE_2_IC":"9.52e-05","Tugl-KD_PGCOE_3_IC":"5.70e-05"},{"Metabolite":"3-Hydroxymethylglutaric acid","PLKO_1_IC":"1.86e-04","PLKO_2_IC":"1.55e-04","PLKO_3_IC":"1.17e-04","Tugl-KD_1_IC":"2.60e-04","Tugl-KD_2_IC":"2.18e-04","Tugl-KD_3_IC":"1.86e-04","Tugl-KD_PGCOE_1_IC":"7.20e-04","Tugl-KD_PGCOE_2_IC":"4.73e-04","Tugl-KD_PGCOE_3_IC":"4.64e-04"},{"Metabolite":"3-Sulfinoalanine","PLKO_1_IC":"3.96e-04","PLKO_2_IC":"3.98e-04","PLKO_3_IC":"2.85e-04","Tugl-KD_1_IC":"3.68e-04","Tugl-KD_2_IC":"1.78e-04","Tugl-KD_3_IC":"2.56e-04","Tugl-KD_PGCOE_1_IC":"4.35e-04","Tugl-KD_PGCOE_2_IC":"3.72e-04","Tugl-KD_PGCOE_3_IC":"2.71e-04"},{"Metabolite":"5'-Phosphoribosyl-N-formylglycinamide","PLKO_1_IC":"2.34e-05","PLKO_2_IC":"3.21e-05","PLKO_3_IC":"3.74e-05","Tugl-KD_1_IC":"9.71e-06","Tugl-KD_2_IC":"1.26e-05","Tugl-KD_3_IC":"1.46e-05","Tugl-KD_PGCOE_1_IC":"2.26e-05","Tugl-KD_PGCOE_2_IC":"4.42e-05","Tugl-KD_PGCOE_3_IC":"4.25e-05"},{"Metabolite":"5-L-Glutamyl-L-alanine","PLKO_1_IC":"1.15e-04","PLKO_2_IC":"1.10e-04","PLKO_3_IC":"1.25e-04","Tugl-KD_1_IC":"6.95e-05","Tugl-KD_2_IC":"4.74e-05","Tugl-KD_3_IC":"5.62e-05","Tugl-KD_PGCOE_1_IC":"9.90e-05","Tugl-KD_PGCOE_2_IC":"7.45e-05","Tugl-KD_PGCOE_3_IC":"8.05e-05"},{"Metabolite":"5-L-Glutamyl-taurine","PLKO_1_IC":"2.52e-04","PLKO_2_IC":"1.99e-04","PLKO_3_IC":"2.67e-04","Tugl-KD_1_IC":"2.51e-04","Tugl-KD_2_IC":"1.54e-04","Tugl-KD_3_IC":"2.87e-04","Tugl-KD_PGCOE_1_IC":"1.72e-04","Tugl-KD_PGCOE_2_IC":"2.32e-04","Tugl-KD_PGCOE_3_IC":"1.69e-04"},{"Metabolite":"5-Thymidylic acid","PLKO_1_IC":"3.07e-05","PLKO_2_IC":"4.23e-05","PLKO_3_IC":"3.03e-05","Tugl-KD_1_IC":"6.97e-05","Tugl-KD_2_IC":"8.38e-05","Tugl-KD_3_IC":"7.17e-05","Tugl-KD_PGCOE_1_IC":"1.10e-04","Tugl-KD_PGCOE_2_IC":"5.82e-05","Tugl-KD_PGCOE_3_IC":"9.26e-05"},{"Metabolite":"6-Phosphogluconic acid","PLKO_1_IC":"3.43e-04","PLKO_2_IC":"3.20e-04","PLKO_3_IC":"4.02e-04","Tugl-KD_1_IC":"1.64e-04","Tugl-KD_2_IC":"2.33e-04","Tugl-KD_3_IC":"2.33e-04","Tugl-KD_PGCOE_1_IC":"2.15e-03","Tugl-KD_PGCOE_2_IC":"1.98e-03","Tugl-KD_PGCOE_3_IC":"2.71e-03"},{"Metabolite":"Acetylcysteine","PLKO_1_IC":"1.80e-05","PLKO_2_IC":"6.33e-06","PLKO_3_IC":"3.56e-06","Tugl-KD_1_IC":"1.17e-05","Tugl-KD_2_IC":"6.49e-06","Tugl-KD_3_IC":"7.86e-06","Tugl-KD_PGCOE_1_IC":"4.25e-05","Tugl-KD_PGCOE_2_IC":"6.19e-05","Tugl-KD_PGCOE_3_IC":"1.91e-05"},{"Metabolite":"Adenosine diphosphate ribose","PLKO_1_IC":"4.48e-04","PLKO_2_IC":"4.62e-04","PLKO_3_IC":"5.13e-04","Tugl-KD_1_IC":"7.88e-04","Tugl-KD_2_IC":"7.23e-04","Tugl-KD_3_IC":"6.48e-04","Tugl-KD_PGCOE_1_IC":"5.93e-04","Tugl-KD_PGCOE_2_IC":"5.91e-04","Tugl-KD_PGCOE_3_IC":"6.85e-04"},{"Metabolite":"Adenosine monophosphate","PLKO_1_IC":"1.05e-02","PLKO_2_IC":"1.38e-02","PLKO_3_IC":"1.67e-02","Tugl-KD_1_IC":"1.12e-02","Tugl-KD_2_IC":"9.06e-03","Tugl-KD_3_IC":"1.44e-02","Tugl-KD_PGCOE_1_IC":"1.17e-02","Tugl-KD_PGCOE_2_IC":"1.68e-02","Tugl-KD_PGCOE_3_IC":"1.59e-02"},{"Metabolite":"Adenosine triphosphate","PLKO_1_IC":"1.07e-01","PLKO_2_IC":"9.38e-02","PLKO_3_IC":"1.10e-01","Tugl-KD_1_IC":"5.59e-02","Tugl-KD_2_IC":"3.58e-02","Tugl-KD_3_IC":"6.50e-02","Tugl-KD_PGCOE_1_IC":"5.70e-02","Tugl-KD_PGCOE_2_IC":"7.36e-02","Tugl-KD_PGCOE_3_IC":"7.38e-02"},{"Metabolite":"ADP","PLKO_1_IC":"3.57e-02","PLKO_2_IC":"3.79e-02","PLKO_3_IC":"4.03e-02","Tugl-KD_1_IC":"2.45e-02","Tugl-KD_2_IC":"1.78e-02","Tugl-KD_3_IC":"2.55e-02","Tugl-KD_PGCOE_1_IC":"2.64e-02","Tugl-KD_PGCOE_2_IC":"3.26e-02","Tugl-KD_PGCOE_3_IC":"3.27e-02"},{"Metabolite":"ADP-glucose","PLKO_1_IC":"2.76e-04","PLKO_2_IC":"2.97e-04","PLKO_3_IC":"3.47e-04","Tugl-KD_1_IC":"3.58e-04","Tugl-KD_2_IC":"4.29e-04","Tugl-KD_3_IC":"4.66e-04","Tugl-KD_PGCOE_1_IC":"3.71e-04","Tugl-KD_PGCOE_2_IC":"4.74e-04","Tugl-KD_PGCOE_3_IC":"5.59e-04"},{"Metabolite":"Alpha-D-Glucose 1,6-bisphosphate","PLKO_1_IC":"2.22e-03","PLKO_2_IC":"1.97e-03","PLKO_3_IC":"1.77e-03","Tugl-KD_1_IC":"2.47e-03","Tugl-KD_2_IC":"2.43e-03","Tugl-KD_3_IC":"2.05e-03","Tugl-KD_PGCOE_1_IC":"2.22e-03","Tugl-KD_PGCOE_2_IC":"1.59e-03","Tugl-KD_PGCOE_3_IC":"2.12e-03"},{"Metabolite":"Beta-D-Glucose 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acid","PLKO_1_IC":"2.99e-04","PLKO_2_IC":"2.49e-04","PLKO_3_IC":"2.47e-04","Tugl-KD_1_IC":"3.15e-04","Tugl-KD_2_IC":"2.25e-04","Tugl-KD_3_IC":"2.15e-04","Tugl-KD_PGCOE_1_IC":"4.08e-04","Tugl-KD_PGCOE_2_IC":"5.69e-04","Tugl-KD_PGCOE_3_IC":"5.83e-04"},{"Metabolite":"Uric acid","PLKO_1_IC":"3.10e-05","PLKO_2_IC":"3.29e-05","PLKO_3_IC":"2.14e-05","Tugl-KD_1_IC":"3.05e-05","Tugl-KD_2_IC":"2.20e-05","Tugl-KD_3_IC":"2.46e-05","Tugl-KD_PGCOE_1_IC":"9.76e-05","Tugl-KD_PGCOE_2_IC":"1.03e-04","Tugl-KD_PGCOE_3_IC":"6.62e-05"},{"Metabolite":"Uridine","PLKO_1_IC":"4.79e-04","PLKO_2_IC":"9.89e-04","PLKO_3_IC":"9.76e-04","Tugl-KD_1_IC":"2.59e-03","Tugl-KD_2_IC":"3.28e-03","Tugl-KD_3_IC":"2.86e-03","Tugl-KD_PGCOE_1_IC":"1.50e-03","Tugl-KD_PGCOE_2_IC":"4.50e-04","Tugl-KD_PGCOE_3_IC":"1.61e-03"},{"Metabolite":"Uridine 5'-diphosphate","PLKO_1_IC":"1.18e-02","PLKO_2_IC":"1.39e-02","PLKO_3_IC":"1.21e-02","Tugl-KD_1_IC":"1.09e-02","Tugl-KD_2_IC":"9.09e-03","Tugl-KD_3_IC":"1.05e-02","Tugl-KD_PGCOE_1_IC":"9.84e-03","Tugl-KD_PGCOE_2_IC":"9.73e-03","Tugl-KD_PGCOE_3_IC":"1.03e-02"},{"Metabolite":"Uridine 5'-monophosphate","PLKO_1_IC":"3.52e-02","PLKO_2_IC":"4.34e-02","PLKO_3_IC":"4.04e-02","Tugl-KD_1_IC":"3.90e-02","Tugl-KD_2_IC":"3.87e-02","Tugl-KD_3_IC":"4.23e-02","Tugl-KD_PGCOE_1_IC":"2.80e-02","Tugl-KD_PGCOE_2_IC":"2.50e-02","Tugl-KD_PGCOE_3_IC":"3.41e-02"},{"Metabolite":"Uridine diphosphate-N-acetylgalactosamine","PLKO_1_IC":"1.44e-02","PLKO_2_IC":"1.56e-02","PLKO_3_IC":"1.72e-02","Tugl-KD_1_IC":"2.15e-02","Tugl-KD_2_IC":"2.20e-02","Tugl-KD_3_IC":"2.23e-02","Tugl-KD_PGCOE_1_IC":"2.17e-02","Tugl-KD_PGCOE_2_IC":"2.54e-02","Tugl-KD_PGCOE_3_IC":"2.57e-02"},{"Metabolite":"Uridine 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"Metabolites":[{"metabolite_name":"(2R)-2-Hydroxy-3-(phosphonatooxy)propanoate"},{"metabolite_name":"2-Aminomuconic acid semialdehyde"},{"metabolite_name":"2-Hydroxyadipic acid"},{"metabolite_name":"2-Hydroxybutyric acid"},{"metabolite_name":"2-Hydroxyglutarate"},{"metabolite_name":"2-Methylglutaric acid"},{"metabolite_name":"2-Phospho-D-glyceric acid"},{"metabolite_name":"2-Propylglutaric acid"},{"metabolite_name":"3-Dehydro-L-gulonate"},{"metabolite_name":"3-Hydroxybutyric acid"},{"metabolite_name":"3-Hydroxymethylglutaric acid"},{"metabolite_name":"3-Sulfinoalanine"},{"metabolite_name":"5'-Phosphoribosyl-N-formylglycinamide"},{"metabolite_name":"5-L-Glutamyl-L-alanine"},{"metabolite_name":"5-L-Glutamyl-taurine"},{"metabolite_name":"5-Thymidylic acid"},{"metabolite_name":"6-Phosphogluconic acid"},{"metabolite_name":"Acetylcysteine"},{"metabolite_name":"Adenosine diphosphate ribose"},{"metabolite_name":"Adenosine monophosphate"},{"metabolite_name":"Adenosine triphosphate"},{"metabolite_name":"ADP"},{"metabolite_name":"ADP-glucose"},{"metabolite_name":"Alpha-D-Glucose 1,6-bisphosphate"},{"metabolite_name":"Beta-D-Glucose 6-phosphate"},{"metabolite_name":"CDP"},{"metabolite_name":"CDP-Ethanolamine"},{"metabolite_name":"cis-Aconitic acid"},{"metabolite_name":"Citric acid"},{"metabolite_name":"Cysteic acid"},{"metabolite_name":"Cytidine monophosphate"},{"metabolite_name":"Cytidine monophosphate N-acetylneuraminic acid"},{"metabolite_name":"Cytidine triphosphate"},{"metabolite_name":"D-Erythrose 4-phosphate"},{"metabolite_name":"D-Fructose 2,6-bisphosphate"},{"metabolite_name":"D-Glucaric acid"},{"metabolite_name":"D-Glucose"},{"metabolite_name":"D-Glucuronic acid 1-phosphate"},{"metabolite_name":"D-Mannose 1-phosphate"},{"metabolite_name":"D-Ribose 5-phosphate"},{"metabolite_name":"D-Sedoheptulose 7-phosphate"},{"metabolite_name":"dADP"},{"metabolite_name":"dCDP"},{"metabolite_name":"dCMP"},{"metabolite_name":"dCTP"},{"metabolite_name":"dGTP"},{"metabolite_name":"dTDP"},{"metabolite_name":"dUMP"},{"metabolite_name":"Fructose 1-phosphate"},{"metabolite_name":"Fructose 1,6-bisphosphate"},{"metabolite_name":"Fructose 6-phosphate"},{"metabolite_name":"Fumaric acid"},{"metabolite_name":"Galactaric acid"},{"metabolite_name":"Galactose 1-phosphate"},{"metabolite_name":"Galacturonic acid"},{"metabolite_name":"Gamma Glutamylglutamic acid"},{"metabolite_name":"Glucaric acid"},{"metabolite_name":"Gluconic acid"},{"metabolite_name":"Glucose 1-phosphate"},{"metabolite_name":"Glutaric acid"},{"metabolite_name":"Glutathione"},{"metabolite_name":"Glycerol 3-phosphate"},{"metabolite_name":"Glycerylphosphorylethanolamine"},{"metabolite_name":"Guanosine diphosphate"},{"metabolite_name":"Guanosine diphosphate mannose"},{"metabolite_name":"Guanosine monophosphate"},{"metabolite_name":"Guanosine triphosphate"},{"metabolite_name":"Homocysteinesulfinic acid"},{"metabolite_name":"Hydroxypropanedioic acid"},{"metabolite_name":"Inosine"},{"metabolite_name":"Inosinic acid"},{"metabolite_name":"Isocitric acid"},{"metabolite_name":"Ketoleucine"},{"metabolite_name":"L-4-Hydroxyglutamate semialdehyde"},{"metabolite_name":"L-Aspartic acid"},{"metabolite_name":"L-beta-aspartyl-L-glutamic acid"},{"metabolite_name":"L-Glutamic acid"},{"metabolite_name":"L-Lactic acid"},{"metabolite_name":"L-Malic acid"},{"metabolite_name":"Malonic acid"},{"metabolite_name":"Mannose 6-phosphate"},{"metabolite_name":"Mesaconic acid"},{"metabolite_name":"Methylmalonic acid"},{"metabolite_name":"N-Acetyl-D-Glucosamine 6-Phosphate"},{"metabolite_name":"N-Acetyl-glucosamine 1-phosphate"},{"metabolite_name":"N-Acetyl-L-aspartic acid"},{"metabolite_name":"N-Acetyl-L-methionine"},{"metabolite_name":"N-Acetylglutamic acid"},{"metabolite_name":"N-Acetylleucine"},{"metabolite_name":"N-Acetylneuraminic acid"},{"metabolite_name":"N-Formyl-L-methionine"},{"metabolite_name":"NADH"},{"metabolite_name":"O-Phosphoethanolamine"},{"metabolite_name":"Orotic acid"},{"metabolite_name":"Orotidine"},{"metabolite_name":"Oxalic acid"},{"metabolite_name":"Oxoglutaric acid"},{"metabolite_name":"Pantothenic acid"},{"metabolite_name":"Phosphocreatine"},{"metabolite_name":"Phosphoenolpyruvic acid"},{"metabolite_name":"Phosphoric acid"},{"metabolite_name":"Phosphoserine"},{"metabolite_name":"Pyridoxal 5'-phosphate"},{"metabolite_name":"Pyroglutamic acid"},{"metabolite_name":"Pyrophosphate"},{"metabolite_name":"Pyruvic acid"},{"metabolite_name":"Ribonic acid"},{"metabolite_name":"Ribose 1-phosphate"},{"metabolite_name":"Ribose 1,5-bisphosphate"},{"metabolite_name":"Sedoheptulose 1,7-bisphosphate"},{"metabolite_name":"Succinic acid"},{"metabolite_name":"Succinic acid semialdehyde"},{"metabolite_name":"Sulfate"},{"metabolite_name":"Taurine"},{"metabolite_name":"Thiamine pyrophosphate"},{"metabolite_name":"Threonic acid"},{"metabolite_name":"UDP-Glucose"},{"metabolite_name":"Ureidosuccinic acid"},{"metabolite_name":"Uric acid"},{"metabolite_name":"Uridine"},{"metabolite_name":"Uridine 5'-diphosphate"},{"metabolite_name":"Uridine 5'-monophosphate"},{"metabolite_name":"Uridine diphosphate-N-acetylgalactosamine"},{"metabolite_name":"Uridine diphosphate-N-acetylglucosamine"},{"metabolite_name":"Uridine diphosphate glucose"},{"metabolite_name":"Uridine triphosphate"},{"metabolite_name":"Xanthylic acid"}]
}

}