{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST001897","ANALYSIS_ID":"AN003079","VERSION":"1","CREATED_ON":"August 3, 2021, 2:19 pm"},

"PROJECT":{"PROJECT_TITLE":"Untargeted metabolomics to understand metabolism of local source of insulin in the eye governed by phagocytosis and starvation","PROJECT_TYPE":"Untargeted Metabolomics (UPLC-MS/MS)","PROJECT_SUMMARY":"Untargeted metabolite analysis was performed on a Thermo Orbitrap IDX Tribrid MS to understand changes in metabolites in eye retina and RPE tissue during starvation. This study also probes the role of certain metabolites during phagocytosis.","INSTITUTE":"University of Virginia","DEPARTMENT":"Center of Cell Clearance , Microbiology, Immunology, and Cancer Biology","LABORATORY":"Kodi Ravichandraan Lab","LAST_NAME":"Etchegaray","FIRST_NAME":"Iker","ADDRESS":"Department of Microbiology, Immunology, and Cancer Biology, University of Virginia","EMAIL":"jie3c@virginia.edu; kr4h@virginia.edu; nw5es@virginia.edu","PHONE":"4023109931"},

"STUDY":{"STUDY_TITLE":"A local source of insulin in the eye governed by phagocytosis and starvation","STUDY_SUMMARY":"Untargeted metabolite analysis was performed on a Thermo Orbitrap IDX Tribrid MS to understand changes in metabolites in eye retina and RPE tissue during starvation. This study also probes the role of certain metabolites during phagocytosis.","INSTITUTE":"University of Virginia","DEPARTMENT":"Center of Cell Clearance , Microbiology, Immunology, and Cancer Biology","LABORATORY":"Kodi Ravichandraan Lab","LAST_NAME":"Etchegaray","FIRST_NAME":"Iker","ADDRESS":"Center of Cell Clearance , Microbiology, Immunology, and Cancer Biology","EMAIL":"kr4h@virginia.edu; jie3c@virginia.edu; nw5es@virginia.edu;","NUM_GROUPS":"4","TOTAL_SUBJECTS":"2","STUDY_TYPE":"Untargeted Metabolomics","PHONE":"4023109931"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"Sample_n_001",
"Factors":{"group":"WT_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_001","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_002",
"Factors":{"group":"WT_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_002","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_003",
"Factors":{"group":"KO_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_003","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_004",
"Factors":{"group":"KO_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_004","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_005",
"Factors":{"group":"WT_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_005","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_006",
"Factors":{"group":"WT_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_006","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_007",
"Factors":{"group":"KO_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_007","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_008",
"Factors":{"group":"KO_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_008","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_009",
"Factors":{"group":"WT_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_009","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_010",
"Factors":{"group":"WT_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_010","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_011",
"Factors":{"group":"KO_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_011","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_012",
"Factors":{"group":"KO_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_012","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_013",
"Factors":{"group":"WT_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_013","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_014",
"Factors":{"group":"WT_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_014","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_015",
"Factors":{"group":"KO_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_015","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_016",
"Factors":{"group":"KO_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_016","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_017",
"Factors":{"group":"WT_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_017","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_018",
"Factors":{"group":"WT_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_018","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_019",
"Factors":{"group":"KO_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_019","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_020",
"Factors":{"group":"KO_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_020","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_QC1",
"Factors":{"group":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_QC1","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_QC2",
"Factors":{"group":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_QC2","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_QC3",
"Factors":{"group":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_QC3","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_QC4",
"Factors":{"group":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_QC4","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_n_QC5",
"Factors":{"group":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_neg_QC5","ionizationMode":"Negative"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_001",
"Factors":{"group":"WT_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_001","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_002",
"Factors":{"group":"WT_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_002","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_003",
"Factors":{"group":"KO_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_003","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_004",
"Factors":{"group":"KO_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_004","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_005",
"Factors":{"group":"WT_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_005","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_006",
"Factors":{"group":"WT_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_006","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_007",
"Factors":{"group":"KO_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_007","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_008",
"Factors":{"group":"KO_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_008","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_009",
"Factors":{"group":"WT_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_009","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_010",
"Factors":{"group":"WT_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_010","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_011",
"Factors":{"group":"KO_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_011","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_012",
"Factors":{"group":"KO_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_012","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_013",
"Factors":{"group":"WT_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_013","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_014",
"Factors":{"group":"WT_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_014","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_015",
"Factors":{"group":"KO_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_015","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_016",
"Factors":{"group":"KO_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_016","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_017",
"Factors":{"group":"WT_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_017","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_018",
"Factors":{"group":"WT_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_018","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_019",
"Factors":{"group":"KO_Retina"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_019","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_020",
"Factors":{"group":"KO_RPE"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_020","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_QC1",
"Factors":{"group":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_QC1","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_QC2",
"Factors":{"group":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_QC2","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_QC3",
"Factors":{"group":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_QC3","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_QC4",
"Factors":{"group":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_QC4","ionizationMode":"Positive"}
},
{
"Subject ID":"-",
"Sample ID":"Sample_p_QC5",
"Factors":{"group":"QC"},
"Additional sample data":{"RAW_FILE_NAME":"x03042021x_pos_QC5","ionizationMode":"Positive"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Overnight fasted mice were euthanized with avertin after light onset. Five replicates each of both Retinal and RPE tissues (from wild type and knock out mice) were harvested/dissected, flash frozen and stored in -80 ºC until extraction. Tissues were thawed on ice and extracted using methanol:chloroform (2:1) at 4C and phase separated using water. Top aq. phase was recovered as metabolite mixture and dried overnight in speedVac and reconstituted in 100 µL of 0.1% Formic acid in water. Ten µl from each tube was removed to create a pooled QC sample that was injected at the beginning and end of the MS sequence run and additional QC samples were injected after every 5 sample injection.","SAMPLE_TYPE":"Eye tissue"},

"TREATMENT":{"TREATMENT_SUMMARY":"NA"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Overnight fasted mice were euthanized with avertin after light onset. Five replicates each of both Retinal and RPE tissues (from wild type and knock out mice) were harvested/dissected, flash frozen and stored in -80 ºC until extraction. Tissues were thawed on ice and extracted using methanol:chloroform (2:1) at 4C and phase separated using water. Top aq. phase was recovered as metabolite mixture and dried overnight in speedVac and reconstituted in 100 µL of 0.1% Formic acid in water. Ten µl from each tube was removed to create a pooled QC sample that was injected at the beginning and end of the MS sequence run and additional QC samples were injected after every 5 sample injection.","PROCESSING_STORAGE_CONDITIONS":"-80℃","EXTRACT_STORAGE":"-80℃"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Low pH polar","CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Thermo Vanquish","COLUMN_NAME":"Waters Acquity BEH C18 (100 x 2mm, 1.7um)","FLOW_GRADIENT":"0-8 minutes 50% B, 8 – 13 minutes held at 98% B, 13.1 to 15.0 minutes revert to 0% B to re-equilibration for next injection","FLOW_RATE":"0.25 mL/min","COLUMN_TEMPERATURE":"30C","SOLVENT_A":"0.1% Formic acid in water","SOLVENT_B":"0.1% Formic acid in Methanol"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Orbitrap IDX","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"Other","ION_MODE":"NEGATIVE","MS_COMMENTS":"Conventional DDA mode was used for data acquisition and samples were randomized during extraction and analysis on the mass spectrometer. The injection volume was 5 µL. ESI source condition were set as follows: Ion source type: H-ESI; positive ion voltage set at 3500 and negative at 2500. Sheath gas was set at 35 and auxiliary gas at 7. Ion transfer tube temperature was set at 275 °C while the vaporizer temperature was set at 320 °C. Data was acquired in full MS mode (1 µscan) at a resolution of 120,000 with a scan range of 67-1000 m/z at a normalized AGC Target of 25% and 50 millisecond of maximum injection time was allowed. RF lens amplitude was set at 35%. Tandem MS/MS performed by applying quadrupole isolation with an isolation window of 1.6 m/z. Activation type was set at HCD and masses were fragmented with HCD Assisted Collision Energy (%) of 15,35,50. Fragment masses were detected by Orbitrap at a resolution of 30,000. For data analysis, Thermo *.RAW files were converted to open source *.mzML format using msConvert software (http://proteowizard.sourceforge.net/download.html) and brought into MS-DIAL software for analysis (http://prime.psc.riken.jp/compms/msdial/main.html). MS-DIAL analysis parameters were as follows: MS1 tolerance was set at 0.01 Da and Ms2 tolerance at 0.025 Da. Data was collected from 0-15 min at a mass range from 50-1000 Da. Peak detection was performed with a minimum peak height of 1x105 and mass slice width of 0.1 Da. Metabolites were identified by searching the MS2 spectra in MS-DIAL public database (290,915 records for positive and 36,848 entries for negative mode; Version 14) using a mass tolerance of 0.01 Da for MS1 and 0.05 Da for MS/MS with identification score cutoff of 60%. Additionally, peaks were also searched against in-house IROA library (in both positive and negative mode) with a mass tolerance of 0.01, identification cutoff of 90% and RT tolerance of 0.5 min (Mass Spectrometry Metabolite Library of Standards (MSMLS); http://iroatech.com/). For peak alignment maximum retention tolerance was set at 0.2 min."},

"MS_METABOLITE_DATA":{
"Units":"intensity",

"Data":[{"Metabolite":"Phosphoric acid","Sample_n_001":"18124160","Sample_n_002":"1711928","Sample_n_003":"7006856","Sample_n_004":"3727045","Sample_n_005":"19712202","Sample_n_006":"2263301","Sample_n_007":"16905086","Sample_n_008":"9918485","Sample_n_009":"17437012","Sample_n_010":"4685478","Sample_n_011":"8273816","Sample_n_012":"3138585","Sample_n_013":"9766460","Sample_n_014":"5639184","Sample_n_015":"21729812","Sample_n_016":"9514229","Sample_n_017":"17046168","Sample_n_018":"6383538","Sample_n_019":"13324464","Sample_n_020":"5445334","Sample_n_QC1":"3547407","Sample_n_QC2":"7051249","Sample_n_QC3":"8144062","Sample_n_QC4":"896333","Sample_n_QC5":"1643433"},{"Metabolite":"SUCCINIC ACID","Sample_n_001":"9852003","Sample_n_002":"974518","Sample_n_003":"14844274","Sample_n_004":"952629","Sample_n_005":"11314920","Sample_n_006":"776669","Sample_n_007":"7404718","Sample_n_008":"922438","Sample_n_009":"13633024","Sample_n_010":"688717","Sample_n_011":"14719687","Sample_n_012":"781369","Sample_n_013":"17347996","Sample_n_014":"915946","Sample_n_015":"15824038","Sample_n_016":"919744","Sample_n_017":"15863357","Sample_n_018":"814940","Sample_n_019":"9836488","Sample_n_020":"867042","Sample_n_QC1":"5186544","Sample_n_QC2":"5005670","Sample_n_QC3":"1811924","Sample_n_QC4":"5791","Sample_n_QC5":"5979"},{"Metabolite":"Glycerophosphate(2)","Sample_n_001":"543618","Sample_n_002":"103841","Sample_n_003":"1066755","Sample_n_004":"131244","Sample_n_005":"868503","Sample_n_006":"131667","Sample_n_007":"783497","Sample_n_008":"125817","Sample_n_009":"626649","Sample_n_010":"96949","Sample_n_011":"773198","Sample_n_012":"52639","Sample_n_013":"909883","Sample_n_014":"131894","Sample_n_015":"828031","Sample_n_016":"102096","Sample_n_017":"368126","Sample_n_018":"157656","Sample_n_019":"880476","Sample_n_020":"112659","Sample_n_QC1":"577540","Sample_n_QC2":"603144","Sample_n_QC3":"368311","Sample_n_QC4":"718","Sample_n_QC5":"0"},{"Metabolite":"FUMARATE (IORA)","Sample_n_001":"2594814","Sample_n_002":"327027","Sample_n_003":"2044056","Sample_n_004":"315670","Sample_n_005":"2469493","Sample_n_006":"346585","Sample_n_007":"1619283","Sample_n_008":"300546","Sample_n_009":"1370783","Sample_n_010":"294286","Sample_n_011":"1610532","Sample_n_012":"202522","Sample_n_013":"2138498","Sample_n_014":"206868","Sample_n_015":"2272390","Sample_n_016":"135813","Sample_n_017":"1830172","Sample_n_018":"315298","Sample_n_019":"2097338","Sample_n_020":"175264","Sample_n_QC1":"846018","Sample_n_QC2":"859660","Sample_n_QC3":"222333","Sample_n_QC4":"0","Sample_n_QC5":"729"},{"Metabolite":"ADENINE","Sample_n_001":"4068211","Sample_n_002":"81497","Sample_n_003":"3143200","Sample_n_004":"51384","Sample_n_005":"3629959","Sample_n_006":"32209","Sample_n_007":"3544886","Sample_n_008":"71647","Sample_n_009":"1792144","Sample_n_010":"41782","Sample_n_011":"2741309","Sample_n_012":"78545","Sample_n_013":"2316671","Sample_n_014":"62687","Sample_n_015":"4371718","Sample_n_016":"44003","Sample_n_017":"2562328","Sample_n_018":"67665","Sample_n_019":"4003549","Sample_n_020":"74924","Sample_n_QC1":"1294870","Sample_n_QC2":"1286713","Sample_n_QC3":"668875","Sample_n_QC4":"18040","Sample_n_QC5":"14584"},{"Metabolite":"Lactic acid","Sample_n_001":"223979376","Sample_n_002":"14129601","Sample_n_003":"158785936","Sample_n_004":"12857257","Sample_n_005":"240881872","Sample_n_006":"10425335","Sample_n_007":"170303216","Sample_n_008":"10275928","Sample_n_009":"159591680","Sample_n_010":"9272425","Sample_n_011":"131934936","Sample_n_012":"6703748","Sample_n_013":"224487424","Sample_n_014":"11079046","Sample_n_015":"220114816","Sample_n_016":"7344698","Sample_n_017":"161706384","Sample_n_018":"9659015","Sample_n_019":"175064896","Sample_n_020":"9630021","Sample_n_QC1":"91001472","Sample_n_QC2":"94471208","Sample_n_QC3":"35337296","Sample_n_QC4":"8392391","Sample_n_QC5":"2145718"},{"Metabolite":"HYPOXANTHINE (IORA)","Sample_n_001":"2098616","Sample_n_002":"2504366","Sample_n_003":"1783153","Sample_n_004":"1995084","Sample_n_005":"2388155","Sample_n_006":"2246398","Sample_n_007":"1738416","Sample_n_008":"2131960","Sample_n_009":"1331365","Sample_n_010":"1769065","Sample_n_011":"1581440","Sample_n_012":"1632509","Sample_n_013":"2275390","Sample_n_014":"2419788","Sample_n_015":"2777110","Sample_n_016":"1800069","Sample_n_017":"2524977","Sample_n_018":"2810524","Sample_n_019":"2464489","Sample_n_020":"1940719","Sample_n_QC1":"2172608","Sample_n_QC2":"1934119","Sample_n_QC3":"765280","Sample_n_QC4":"25037","Sample_n_QC5":"949"},{"Metabolite":"OROTATE 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}

}