{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002055","ANALYSIS_ID":"AN003346","VERSION":"1","CREATED_ON":"January 8, 2022, 7:18 am"},

"PROJECT":{"PROJECT_TITLE":"Metabolomic Profiling of Human Pluripotent Stem Cell Differentiation into Lung Progenitors","PROJECT_TYPE":"Developmental metabolites and Biomarker discovery","PROJECT_SUMMARY":"Metabolism is vital to cellular function and tissue homeostasis during human lung development. In utero, embryonic pluripotent stem cells undergo endodermal differentiation towards a lung progenitor cell fate that can be mimicked in vitro using induced human pluripotent stem cells (hiPSCs) to study genetic mutations. To identify differences between wild type and surfactant protein B (SFTPB)-deficient cell lines during endoderm specification towards lung, we used an untargeted metabolomics approach to evaluate the developmental changes in metabolites. We found that the metabolites most enriched during the differentiation from pluripotent stem cell to lung progenitor cell, regardless of cell line, were sphingomyelins and phosphatidylcholines, two important lipid classes in fetal lung development. The SFTPB mutation had no metabolic impact on early endodermal lung development. The identified metabolite signatures during lung progenitor cell differentiation may be utilized as biomarkers for normal embryonic lung development.","INSTITUTE":"The Hospital for Sick Children","LAST_NAME":"Post","FIRST_NAME":"Martin","ADDRESS":"555 University Avenue","EMAIL":"martin.post@sickkids.ca","PHONE":"4168136772"},

"STUDY":{"STUDY_TITLE":"Metabolomic Profiling of Human Pluripotent Stem Cell Differentiation into Lung Progenitors","STUDY_SUMMARY":"Metabolism is vital to cellular function and tissue homeostasis during human lung development. In utero, embryonic pluripotent stem cells undergo endodermal differentiation towards a lung progenitor cell fate that can be mimicked in vitro using induced human pluripotent stem cells (hiPSCs) to study genetic mutations. To identify differences between wild type and surfactant protein B (SFTPB)-deficient cell lines during endoderm specification towards lung, we used an untargeted metabolomics approach to evaluate the developmental changes in metabolites. We found that the metabolites most enriched during the differentiation from pluripotent stem cell to lung progenitor cell, regardless of cell line, were sphingomyelins and phosphatidylcholines, two important lipid classes in fetal lung development. The SFTPB mutation had no metabolic impact on early endodermal lung development. The identified metabolite signatures during lung progenitor cell differentiation may be utilized as biomarkers for normal embryonic lung development.","INSTITUTE":"The Hospital for Sick Children","LAST_NAME":"Post","FIRST_NAME":"Martin","ADDRESS":"555 University Avenue","EMAIL":"martin.post@sickkids.ca","PHONE":"4168136772"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"1 - CA1 1",
"Factors":{"Differentiation stage":"PSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_74_0_1_1_00_1007638751","RAW_FILE_NAME":"KIT3-0-5504_1007639557_74_0_1_1_00_1007638751"}
},
{
"Subject ID":"-",
"Sample ID":"2 - CA1 2",
"Factors":{"Differentiation stage":"PSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_86_0_1_1_00_1007638766","RAW_FILE_NAME":"KIT3-0-5504_1007639557_86_0_1_1_00_1007638766"}
},
{
"Subject ID":"-",
"Sample ID":"3 - CA1 3",
"Factors":{"Differentiation stage":"PSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_03_0_1_1_00_1007638771","RAW_FILE_NAME":"KIT3-0-5504_1007639557_03_0_1_1_00_1007638771"}
},
{
"Subject ID":"-",
"Sample ID":"4 - CA1 4",
"Factors":{"Differentiation stage":"PSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_15_0_1_1_00_1007638785","RAW_FILE_NAME":"KIT3-0-5504_1007639557_15_0_1_1_00_1007638785"}
},
{
"Subject ID":"-",
"Sample ID":"5 - CA1 5",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_27_0_1_1_00_1007638790","RAW_FILE_NAME":"KIT3-0-5504_1007639557_27_0_1_1_00_1007638790"}
},
{
"Subject ID":"-",
"Sample ID":"6 - CA1 6",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_39_0_1_1_00_1007638801","RAW_FILE_NAME":"KIT3-0-5504_1007639557_39_0_1_1_00_1007638801"}
},
{
"Subject ID":"-",
"Sample ID":"7 - CA1 7",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_51_0_1_1_00_1007638815","RAW_FILE_NAME":"KIT3-0-5504_1007639557_51_0_1_1_00_1007638815"}
},
{
"Subject ID":"-",
"Sample ID":"8 - CA1 8",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_63_0_1_1_00_1007638820","RAW_FILE_NAME":"KIT3-0-5504_1007639557_63_0_1_1_00_1007638820"}
},
{
"Subject ID":"-",
"Sample ID":"9 - CA1 9",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_75_0_1_1_00_1007638834","RAW_FILE_NAME":"KIT3-0-5504_1007639557_75_0_1_1_00_1007638834"}
},
{
"Subject ID":"-",
"Sample ID":"10 - CA1 10",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_87_0_1_1_00_1007638849","RAW_FILE_NAME":"KIT3-0-5504_1007639557_87_0_1_1_00_1007638849"}
},
{
"Subject ID":"-",
"Sample ID":"11 - CA1 11",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_04_0_1_1_00_1007638853","RAW_FILE_NAME":"KIT3-0-5504_1007639557_04_0_1_1_00_1007638853"}
},
{
"Subject ID":"-",
"Sample ID":"12 - CA1 12",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_16_0_1_1_00_1007638868","RAW_FILE_NAME":"KIT3-0-5504_1007639557_16_0_1_1_00_1007638868"}
},
{
"Subject ID":"-",
"Sample ID":"13 - CA1 13",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_28_0_1_1_00_1007638872","RAW_FILE_NAME":"KIT3-0-5504_1007639557_28_0_1_1_00_1007638872"}
},
{
"Subject ID":"-",
"Sample ID":"14 - CA1 14",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_40_0_1_1_00_1007638887","RAW_FILE_NAME":"KIT3-0-5504_1007639557_40_0_1_1_00_1007638887"}
},
{
"Subject ID":"-",
"Sample ID":"15 - CA1 15",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_52_0_1_1_00_1007638891","RAW_FILE_NAME":"KIT3-0-5504_1007639557_52_0_1_1_00_1007638891"}
},
{
"Subject ID":"-",
"Sample ID":"16 - CA1 16",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_64_0_1_1_00_1007638902","RAW_FILE_NAME":"KIT3-0-5504_1007639557_64_0_1_1_00_1007638902"}
},
{
"Subject ID":"-",
"Sample ID":"17 - NCRM1 1",
"Factors":{"Differentiation stage":"iPSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_76_0_1_1_00_1007638917","RAW_FILE_NAME":"KIT3-0-5504_1007639557_76_0_1_1_00_1007638917"}
},
{
"Subject ID":"-",
"Sample ID":"18 - NCRM1 2",
"Factors":{"Differentiation stage":"iPSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_88_0_1_1_00_1007638921","RAW_FILE_NAME":"KIT3-0-5504_1007639557_88_0_1_1_00_1007638921"}
},
{
"Subject ID":"-",
"Sample ID":"19 - NCRM1 3",
"Factors":{"Differentiation stage":"iPSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_05_0_1_1_00_1007638936","RAW_FILE_NAME":"KIT3-0-5504_1007639557_05_0_1_1_00_1007638936"}
},
{
"Subject ID":"-",
"Sample ID":"20 - NCRM1 4",
"Factors":{"Differentiation stage":"iPSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_17_0_1_1_00_1007638941","RAW_FILE_NAME":"KIT3-0-5504_1007639557_17_0_1_1_00_1007638941"}
},
{
"Subject ID":"-",
"Sample ID":"21 - NCRM1 5",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_29_0_1_1_00_1007638955","RAW_FILE_NAME":"KIT3-0-5504_1007639557_29_0_1_1_00_1007638955"}
},
{
"Subject ID":"-",
"Sample ID":"22 - NCRM1 6",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_41_0_1_1_00_1007638960","RAW_FILE_NAME":"KIT3-0-5504_1007639557_41_0_1_1_00_1007638960"}
},
{
"Subject ID":"-",
"Sample ID":"23 - NCRM1 7",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_53_0_1_1_00_1007638974","RAW_FILE_NAME":"KIT3-0-5504_1007639557_53_0_1_1_00_1007638974"}
},
{
"Subject ID":"-",
"Sample ID":"24 - NCRM1 8",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_65_0_1_1_00_1007638989","RAW_FILE_NAME":"KIT3-0-5504_1007639557_65_0_1_1_00_1007638989"}
},
{
"Subject ID":"-",
"Sample ID":"25 - NCRM1 9",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_77_0_1_1_00_1007638993","RAW_FILE_NAME":"KIT3-0-5504_1007639557_77_0_1_1_00_1007638993"}
},
{
"Subject ID":"-",
"Sample ID":"26 - NCRM1 10",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_89_0_1_1_00_1007639005","RAW_FILE_NAME":"KIT3-0-5504_1007639557_89_0_1_1_00_1007639005"}
},
{
"Subject ID":"-",
"Sample ID":"27 - NCRM1 11",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_06_0_1_1_00_1007639010","RAW_FILE_NAME":"KIT3-0-5504_1007639557_06_0_1_1_00_1007639010"}
},
{
"Subject ID":"-",
"Sample ID":"28 - NCRM1 12",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_18_0_1_1_00_1007639024","RAW_FILE_NAME":"KIT3-0-5504_1007639557_18_0_1_1_00_1007639024"}
},
{
"Subject ID":"-",
"Sample ID":"29 - NCRM1 13",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_30_0_1_1_00_1007639039","RAW_FILE_NAME":"KIT3-0-5504_1007639557_30_0_1_1_00_1007639039"}
},
{
"Subject ID":"-",
"Sample ID":"30 - NCRM1 14",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_42_0_1_1_00_1007639043","RAW_FILE_NAME":"KIT3-0-5504_1007639557_42_0_1_1_00_1007639043"}
},
{
"Subject ID":"-",
"Sample ID":"31 - NCRM1 15",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_54_0_1_1_00_1007639058","RAW_FILE_NAME":"KIT3-0-5504_1007639557_54_0_1_1_00_1007639058"}
},
{
"Subject ID":"-",
"Sample ID":"32 - NCRM1 16",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_66_0_1_1_00_1007639062","RAW_FILE_NAME":"KIT3-0-5504_1007639557_66_0_1_1_00_1007639062"}
},
{
"Subject ID":"-",
"Sample ID":"33 - ICD 1",
"Factors":{"Differentiation stage":"iPSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_78_0_1_1_00_1007639077","RAW_FILE_NAME":"KIT3-0-5504_1007639557_78_0_1_1_00_1007639077"}
},
{
"Subject ID":"-",
"Sample ID":"34 - ICD 2",
"Factors":{"Differentiation stage":"iPSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_90_0_1_1_00_1007639081","RAW_FILE_NAME":"KIT3-0-5504_1007639557_90_0_1_1_00_1007639081"}
},
{
"Subject ID":"-",
"Sample ID":"35 - ICD 3",
"Factors":{"Differentiation stage":"iPSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_07_0_1_1_00_1007639096","RAW_FILE_NAME":"KIT3-0-5504_1007639557_07_0_1_1_00_1007639096"}
},
{
"Subject ID":"-",
"Sample ID":"36 - ICD 4",
"Factors":{"Differentiation stage":"iPSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_19_0_1_1_00_1007639107","RAW_FILE_NAME":"KIT3-0-5504_1007639557_19_0_1_1_00_1007639107"}
},
{
"Subject ID":"-",
"Sample ID":"37 - ICD 5",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_31_0_1_1_00_1007639111","RAW_FILE_NAME":"KIT3-0-5504_1007639557_31_0_1_1_00_1007639111"}
},
{
"Subject ID":"-",
"Sample ID":"38 - ICD 6",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_55_0_1_1_00_1007639126","RAW_FILE_NAME":"KIT3-0-5504_1007639557_55_0_1_1_00_1007639126"}
},
{
"Subject ID":"-",
"Sample ID":"39 - ICD 7",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_67_0_1_1_00_1007639131","RAW_FILE_NAME":"KIT3-0-5504_1007639557_67_0_1_1_00_1007639131"}
},
{
"Subject ID":"-",
"Sample ID":"40 - ICD 8",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_79_0_1_1_00_1007639145","RAW_FILE_NAME":"KIT3-0-5504_1007639557_79_0_1_1_00_1007639145"}
},
{
"Subject ID":"-",
"Sample ID":"41 - ICD 9",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_91_0_1_1_00_1007639150","RAW_FILE_NAME":"KIT3-0-5504_1007639557_91_0_1_1_00_1007639150"}
},
{
"Subject ID":"-",
"Sample ID":"42 - ICD 10",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_08_0_1_1_00_1007639164","RAW_FILE_NAME":"KIT3-0-5504_1007639557_08_0_1_1_00_1007639164"}
},
{
"Subject ID":"-",
"Sample ID":"43 - ICD 11",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_20_0_1_1_00_1007639179","RAW_FILE_NAME":"KIT3-0-5504_1007639557_20_0_1_1_00_1007639179"}
},
{
"Subject ID":"-",
"Sample ID":"44 - ICD 12",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_32_0_1_1_00_1007639183","RAW_FILE_NAME":"KIT3-0-5504_1007639557_32_0_1_1_00_1007639183"}
},
{
"Subject ID":"-",
"Sample ID":"45 - ICD 13",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_44_0_1_1_00_1007639198","RAW_FILE_NAME":"KIT3-0-5504_1007639557_44_0_1_1_00_1007639198"}
},
{
"Subject ID":"-",
"Sample ID":"46 - ICD 14",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_56_0_1_1_00_1007639209","RAW_FILE_NAME":"KIT3-0-5504_1007639557_56_0_1_1_00_1007639209"}
},
{
"Subject ID":"-",
"Sample ID":"47 - ICD 15",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_68_0_1_1_00_1007639213","RAW_FILE_NAME":"KIT3-0-5504_1007639557_68_0_1_1_00_1007639213"}
},
{
"Subject ID":"-",
"Sample ID":"48 - ICD 16",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_80_0_1_1_00_1007639228","RAW_FILE_NAME":"KIT3-0-5504_1007639557_80_0_1_1_00_1007639228"}
},
{
"Subject ID":"-",
"Sample ID":"49 - ICE 1",
"Factors":{"Differentiation stage":"iPSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_92_0_1_1_00_1007639232","RAW_FILE_NAME":"KIT3-0-5504_1007639557_92_0_1_1_00_1007639232"}
},
{
"Subject ID":"-",
"Sample ID":"50 - ICE 2",
"Factors":{"Differentiation stage":"iPSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_09_0_1_1_00_1007639247","RAW_FILE_NAME":"KIT3-0-5504_1007639557_09_0_1_1_00_1007639247"}
},
{
"Subject ID":"-",
"Sample ID":"51 - ICE 3",
"Factors":{"Differentiation stage":"iPSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_21_0_1_1_00_1007639251","RAW_FILE_NAME":"KIT3-0-5504_1007639557_21_0_1_1_00_1007639251"}
},
{
"Subject ID":"-",
"Sample ID":"52 - ICE 4",
"Factors":{"Differentiation stage":"iPSC"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_33_0_1_1_00_1007639266","RAW_FILE_NAME":"KIT3-0-5504_1007639557_33_0_1_1_00_1007639266"}
},
{
"Subject ID":"-",
"Sample ID":"53 - ICE 5",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_45_0_1_1_00_1007639271","RAW_FILE_NAME":"KIT3-0-5504_1007639557_45_0_1_1_00_1007639271"}
},
{
"Subject ID":"-",
"Sample ID":"54 - ICE 6",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_57_0_1_1_00_1007639285","RAW_FILE_NAME":"KIT3-0-5504_1007639557_57_0_1_1_00_1007639285"}
},
{
"Subject ID":"-",
"Sample ID":"55 - ICE 7",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_69_0_1_1_00_1007639290","RAW_FILE_NAME":"KIT3-0-5504_1007639557_69_0_1_1_00_1007639290"}
},
{
"Subject ID":"-",
"Sample ID":"56 - ICE 8",
"Factors":{"Differentiation stage":"Definitive Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_81_0_1_1_00_1007639301","RAW_FILE_NAME":"KIT3-0-5504_1007639557_81_0_1_1_00_1007639301"}
},
{
"Subject ID":"-",
"Sample ID":"57 - ICE 9",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_93_0_1_1_00_1007639315","RAW_FILE_NAME":"KIT3-0-5504_1007639557_93_0_1_1_00_1007639315"}
},
{
"Subject ID":"-",
"Sample ID":"58 - ICE 10",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_10_0_1_1_00_1007639320","RAW_FILE_NAME":"KIT3-0-5504_1007639557_10_0_1_1_00_1007639320"}
},
{
"Subject ID":"-",
"Sample ID":"59 - ICE 11",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_22_0_1_1_00_1007639334","RAW_FILE_NAME":"KIT3-0-5504_1007639557_22_0_1_1_00_1007639334"}
},
{
"Subject ID":"-",
"Sample ID":"60 - ICE 12",
"Factors":{"Differentiation stage":"Anterior Foregut Endoderm"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_34_0_1_1_00_1007639349","RAW_FILE_NAME":"KIT3-0-5504_1007639557_34_0_1_1_00_1007639349"}
},
{
"Subject ID":"-",
"Sample ID":"61 - ICE 13",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_46_0_1_1_00_1007639353","RAW_FILE_NAME":"KIT3-0-5504_1007639557_46_0_1_1_00_1007639353"}
},
{
"Subject ID":"-",
"Sample ID":"62 - ICE 14",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_58_0_1_1_00_1007639368","RAW_FILE_NAME":"KIT3-0-5504_1007639557_58_0_1_1_00_1007639368"}
},
{
"Subject ID":"-",
"Sample ID":"63 - ICE 15",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_70_0_1_1_00_1007639372","RAW_FILE_NAME":"KIT3-0-5504_1007639557_70_0_1_1_00_1007639372"}
},
{
"Subject ID":"-",
"Sample ID":"64 - ICE 16",
"Factors":{"Differentiation stage":"Lung Progenitor Cell"},
"Additional sample data":{"RAW_FILE_NAME":"KIT2-0-5504_1007639557_82_0_1_1_00_1007639387","RAW_FILE_NAME":"KIT3-0-5504_1007639557_82_0_1_1_00_1007639387"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Samples were analyzed for 180 metabolites using the AbsoluteIDQ® p180 kit from Biocrates Life Sciences AG at the Analytical Facility for Bioactive Molecules (The Hospital for Sick Children, Toronto, Canada). Collected cell pellets were resuspended in 15 % ice-cold 10 mM Phosphate Buffer (PB) + 85 % EtOH as per AbsoluteIDQ® p180 kit protocol. Resuspended cells were subjected to three rounds of sonication and rapid freeze thawing. Final suspension was then centrifuged at 20,000 x g for 10 minutes at 4°C. A small aliquot was taken for protein assay, and the remainder of the supernatant was used for metabolic analysis. Samples, standards, and controls (10 mL each) were added to the Biocrates 96-well filter plate with internal standard, dried under nitrogen, derivatized with phenyl isothiocyanate, and then extracted with methanol, as per kit instructions.","SAMPLE_TYPE":"human cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"No treatment"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"At each differentiation step, DE, AFE and LPC, cells were analyzed by FACS for stage specific markers. The differentiated cells were harvested with TrypLE at 37 °C for 5-10 minutes and collected by centrifugation at 300 g for 5 minutes at room temperature. The cell pellets were resuspended in 3% (v/v) FBS in PBS, cell aggregates were removed using a cell strainer with a 40-µm pore size and single cells were collected. For surface antigens, the cells were incubated with primary antibodies for 30 minutes on ice with gentle shaking, washed twice with 3% (v/v) FBS in PBS, and if necessary, incubated with the secondary antibodies for 30 minutes followed by two more rinses with 3% (v/v) FBS in PBS. For DE cells, we used PE conjugated mouse anti-human CXCR4 and APC conjugated mouse anti-human cKit antibodies; AFE cells were stained with PE-conjugated mouse anti-human CD56 and APC conjugated mouse anti-human CD271 antibodies and LPCs we identified using mouse anti-human CPM antibody. Alexa Fluor 488 donkey anti-mouse IgG was used as the secondary antibody against primary CPM antibody. The cells were either sorted using the BD aria FACS sorter at the Sick Kids FACS core and/or analyzed using a Beckman Coulter Gallios flow cytometer. Unstained controls were used to set up gates for FSC and SSC and double stained cells underwent fluorescence minus one (FMO) to ensure accurate gating. Sorted cells were collected and the spun down into a cell pellet and stored in -80C degrees for further processing. The endodermal differentiations and cell sorts were repeated at four different times with two biological repeats."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Agilent 1290 Infinity","COLUMN_NAME":"Agilent Eclipse XDB-C18 (100 x 3.0mm)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"ABI Sciex 5500 QTrap","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"Analyst1.7 (Sciex); MetIDQ (Biocrates)"},

"MS_METABOLITE_DATA":{
"Units":"uM",

"Data":[{"Metabolite":"Ac-Orn","1 - CA1 1":"0","2 - CA1 2":"0","3 - CA1 3":"0","4 - CA1 4":"0","5 - CA1 5":"0","6 - CA1 6":"0","7 - CA1 7":"0","8 - CA1 8":"0","9 - CA1 9":"0","10 - CA1 10":"0","11 - CA1 11":"0","12 - CA1 12":"0","13 - CA1 13":"0","14 - CA1 14":"0","15 - CA1 15":"0","16 - CA1 16":"0","17 - NCRM1 1":"0","18 - NCRM1 2":"0","19 - NCRM1 3":"0","20 - NCRM1 4":"0","21 - NCRM1 5":"0","22 - NCRM1 6":"0","23 - NCRM1 7":"0","24 - NCRM1 8":"0","25 - NCRM1 9":"0","26 - NCRM1 10":"0","27 - NCRM1 11":"0","28 - NCRM1 12":"0","29 - NCRM1 13":"0.142","30 - NCRM1 14":"0","31 - NCRM1 15":"0","32 - NCRM1 16":"0","33 - ICD 1":"0","34 - ICD 2":"0","35 - ICD 3":"0","36 - ICD 4":"0","37 - ICD 5":"0","38 - ICD 6":"0","39 - ICD 7":"0","40 - ICD 8":"0","41 - ICD 9":"0","42 - ICD 10":"0","43 - ICD 11":"0","44 - ICD 12":"0","45 - ICD 13":"0","46 - ICD 14":"0","47 - ICD 15":"0","48 - ICD 16":"0","49 - ICE 1":"0","50 - ICE 2":"0","51 - ICE 3":"0","52 - ICE 4":"0","53 - ICE 5":"0","54 - ICE 6":"0","55 - 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ICE 9":"0.945","58 - ICE 10":"1.71","59 - ICE 11":"1.16","60 - ICE 12":"2.46","61 - ICE 13":"1.5","62 - ICE 14":"1.34","63 - ICE 15":"0.825","64 - ICE 16":"2.63"},{"Metabolite":"DOPA","1 - CA1 1":"0","2 - CA1 2":"0","3 - CA1 3":"0","4 - CA1 4":"0","5 - CA1 5":"0","6 - CA1 6":"0","7 - CA1 7":"0","8 - CA1 8":"0","9 - CA1 9":"0","10 - CA1 10":"0","11 - CA1 11":"0","12 - CA1 12":"0","13 - CA1 13":"0","14 - CA1 14":"0","15 - CA1 15":"0","16 - CA1 16":"0","17 - NCRM1 1":"0","18 - NCRM1 2":"0","19 - NCRM1 3":"0","20 - NCRM1 4":"0","21 - NCRM1 5":"0","22 - NCRM1 6":"0","23 - NCRM1 7":"0","24 - NCRM1 8":"0","25 - NCRM1 9":"0","26 - NCRM1 10":"0","27 - NCRM1 11":"0","28 - NCRM1 12":"0","29 - NCRM1 13":"0","30 - NCRM1 14":"0","31 - NCRM1 15":"0","32 - NCRM1 16":"0","33 - ICD 1":"0","34 - ICD 2":"0","35 - ICD 3":"0","36 - ICD 4":"0","37 - ICD 5":"0","38 - ICD 6":"0","39 - ICD 7":"0","40 - ICD 8":"0","41 - ICD 9":"0","42 - ICD 10":"0","43 - ICD 11":"0","44 - ICD 12":"0","45 - ICD 13":"0","46 - ICD 14":"0","47 - 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ICE 15":"0.113","64 - ICE 16":"0.058"},{"Metabolite":"Met-SO","1 - CA1 1":"1.25","2 - CA1 2":"0","3 - CA1 3":"0","4 - CA1 4":"0","5 - CA1 5":"0","6 - CA1 6":"0","7 - CA1 7":"0","8 - CA1 8":"0","9 - CA1 9":"0","10 - CA1 10":"0","11 - CA1 11":"0","12 - CA1 12":"0","13 - CA1 13":"0","14 - CA1 14":"0","15 - CA1 15":"0","16 - CA1 16":"0","17 - NCRM1 1":"0","18 - NCRM1 2":"0","19 - NCRM1 3":"0","20 - NCRM1 4":"0","21 - NCRM1 5":"0","22 - NCRM1 6":"0","23 - NCRM1 7":"0","24 - NCRM1 8":"0","25 - NCRM1 9":"0","26 - NCRM1 10":"0","27 - NCRM1 11":"0","28 - NCRM1 12":"0","29 - NCRM1 13":"0","30 - NCRM1 14":"0","31 - NCRM1 15":"0","32 - NCRM1 16":"0","33 - ICD 1":"0","34 - ICD 2":"0","35 - ICD 3":"0","36 - ICD 4":"0","37 - ICD 5":"0","38 - ICD 6":"0","39 - ICD 7":"0","40 - ICD 8":"0","41 - ICD 9":"0","42 - ICD 10":"0","43 - ICD 11":"0","44 - ICD 12":"0","45 - ICD 13":"0","46 - ICD 14":"0","47 - ICD 15":"0","48 - ICD 16":"0","49 - ICE 1":"0","50 - ICE 2":"0","51 - ICE 3":"0","52 - ICE 4":"0","53 - ICE 5":"0","54 - 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ICD 2":"1.6","35 - ICD 3":"0.231","36 - ICD 4":"7.75","37 - ICD 5":"0.3","38 - ICD 6":"0.825","39 - ICD 7":"0.361","40 - ICD 8":"0.297","41 - ICD 9":"1.03","42 - ICD 10":"0.177","43 - ICD 11":"0.73","44 - ICD 12":"0.46","45 - ICD 13":"0.335","46 - ICD 14":"0.72","47 - ICD 15":"0.665","48 - ICD 16":"0.369","49 - ICE 1":"0.75","50 - ICE 2":"3.97","51 - ICE 3":"0.6","52 - ICE 4":"3.26","53 - ICE 5":"0.342","54 - ICE 6":"0.156","55 - ICE 7":"0.605","56 - ICE 8":"0.8","57 - ICE 9":"0.344","58 - ICE 10":"0.785","59 - ICE 11":"0.394","60 - ICE 12":"0.479","61 - ICE 13":"0.545","62 - ICE 14":"0.585","63 - ICE 15":"2.95","64 - ICE 16":"0.395"},{"Metabolite":"Val","1 - CA1 1":"102","2 - CA1 2":"0.349","3 - CA1 3":"0.265","4 - CA1 4":"19.7","5 - CA1 5":"0","6 - CA1 6":"1.22","7 - CA1 7":"0","8 - CA1 8":"0","9 - CA1 9":"0","10 - CA1 10":"0","11 - CA1 11":"1.09","12 - CA1 12":"0.02","13 - CA1 13":"0","14 - CA1 14":"0","15 - CA1 15":"9.05","16 - CA1 16":"0","17 - NCRM1 1":"1.59","18 - NCRM1 2":"0","19 - 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"Metabolites":[{"metabolite_name":"Ac-Orn"},{"metabolite_name":"ADMA"},{"metabolite_name":"alpha-AAA"},{"metabolite_name":"c4-OH-Pro"},{"metabolite_name":"Carnosine"},{"metabolite_name":"Creatinine"},{"metabolite_name":"DOPA"},{"metabolite_name":"Dopamine"},{"metabolite_name":"Histamine"},{"metabolite_name":"Kynurenine"},{"metabolite_name":"Met-SO"},{"metabolite_name":"Nitro-Tyr"},{"metabolite_name":"PEA"},{"metabolite_name":"Putrescine"},{"metabolite_name":"SDMA"},{"metabolite_name":"Serotonin"},{"metabolite_name":"Spermidine"},{"metabolite_name":"Spermine"},{"metabolite_name":"t4-OH-Pro"},{"metabolite_name":"Taurine"},{"metabolite_name":"total DMA"},{"metabolite_name":"Ala"},{"metabolite_name":"Arg"},{"metabolite_name":"Asn"},{"metabolite_name":"Asp"},{"metabolite_name":"Cit"},{"metabolite_name":"Gln"},{"metabolite_name":"Glu"},{"metabolite_name":"Gly"},{"metabolite_name":"His"},{"metabolite_name":"Ile"},{"metabolite_name":"Leu"},{"metabolite_name":"Lys"},{"metabolite_name":"Met"},{"metabolite_name":"Orn"},{"metabolite_name":"Phe"},{"metabolite_name":"Pro"},{"metabolite_name":"Ser"},{"metabolite_name":"Thr"},{"metabolite_name":"Trp"},{"metabolite_name":"Tyr"},{"metabolite_name":"Val"}]
}

}