{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002058","ANALYSIS_ID":"AN003350","VERSION":"1","CREATED_ON":"January 12, 2022, 12:50 pm"},

"PROJECT":{"PROJECT_TITLE":"Unchecked oxidative stress is an insurmountable barrier for tumour cells that disseminate to skeletal muscle","PROJECT_SUMMARY":"Skeletal muscle has been recognized as an inhospitable site for disseminated tumour cells (DTCs) for decades, yet its antimetastatic nature has eluded a thorough mechanistic description. Here, we show that DTCs traffic to and persist within skeletal muscle, raising the question as to how this tissue suppresses colonization. We employed mouse and organotypic culture models along with metabolomic profiling and ultimately find that oxidative stress is a principal suppressor of DTC proliferation in skeletal muscle. DTCs bypassed this oxidative constraint upon colonization of more fertile sites, but were unable to in muscle. Functional studies demonstrated that disrupting redox homeostasis via chemogenetic induction of reactive oxygen species slowed proliferation in lung. Conversely, enhancing antioxidant potential of tumour cells via ectopic expression of catalase allowed robust colonization of skeletal muscle. These findings reveal a profound metabolic bottleneck imposed on DTCs and sustained by skeletal muscle. Understanding this biology could reveal novel DTC vulnerabilities.","INSTITUTE":"University of Colorado Anschutz Medical Campus","LAST_NAME":"Nemkov","FIRST_NAME":"Travis","ADDRESS":"12801 E 17th Avenue, RC-1 South, Rm 9403G, Aurora, CO, 80045, USA","EMAIL":"travis.nemkov@cuanschutz.edu","PHONE":"303-724-3253"},

"STUDY":{"STUDY_TITLE":"Muscle/Lung/Tumor metabolomics","STUDY_SUMMARY":"Skeletal muscle (SkM, tibialis anterior and upper arm) and lung samples analyzed by LC-MS metabolomics. These tissue types are analyzed as healthy control, Mcherry+ tumor, or adjacent tissue.","INSTITUTE":"University of Colorado Anschutz Medical Campus","LAST_NAME":"Nemkov","FIRST_NAME":"Travis","ADDRESS":"12801 East 17th Ave. Research 1 South Rm 9121 Aurora CO 80045","EMAIL":"travis.nemkov@cuanschutz.edu","PHONE":"303-724-3253"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"4T1-1",
"Sample ID":"4T1-1_R7-",
"Factors":{"Tissue":"Tibialis_anterior","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-1_R7-.raw"}
},
{
"Subject ID":"4T1-15",
"Sample ID":"4T1-15_R11-",
"Factors":{"Tissue":"Tibialis_anterior","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-15_R11-.raw"}
},
{
"Subject ID":"4T1-19",
"Sample ID":"4T1-19_R15-",
"Factors":{"Tissue":"Upper_Arm_SkM","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-19_R15-.raw"}
},
{
"Subject ID":"4T1-27",
"Sample ID":"4T1-27_R18-",
"Factors":{"Tissue":"Upper_Arm_SkM","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-27_R18-.raw"}
},
{
"Subject ID":"CTL-1",
"Sample ID":"CTL-1_R23-",
"Factors":{"Tissue":"Tibialis_anterior","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-1_R23-.raw"}
},
{
"Subject ID":"CTL-5",
"Sample ID":"CTL-5_R2-",
"Factors":{"Tissue":"Tibialis_anterior","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-5_R2-.raw"}
},
{
"Subject ID":"CTL-9",
"Sample ID":"CTL-9_R1-",
"Factors":{"Tissue":"Tibialis_anterior","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-9_R1-.raw"}
},
{
"Subject ID":"CTL-3",
"Sample ID":"CTL-3_R6-",
"Factors":{"Tissue":"Upper_Arm_SkM","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-3_R6-.raw"}
},
{
"Subject ID":"CTL-7",
"Sample ID":"CTL-7_R3-",
"Factors":{"Tissue":"Upper_Arm_SkM","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-7_R3-.raw"}
},
{
"Subject ID":"CTL-11",
"Sample ID":"CTL-11_R21-",
"Factors":{"Tissue":"Upper_Arm_SkM","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-11_R21-.raw"}
},
{
"Subject ID":"4T1-17",
"Sample ID":"4T1-17_R4-",
"Factors":{"Tissue":"Lung","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-17_R4-.raw"}
},
{
"Subject ID":"4T1-21",
"Sample ID":"4T1-21_R22-",
"Factors":{"Tissue":"Lung","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-21_R22-.raw"}
},
{
"Subject ID":"4T1-25",
"Sample ID":"4T1-25_R16-",
"Factors":{"Tissue":"Lung","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-25_R16-.raw"}
},
{
"Subject ID":"CTL-4",
"Sample ID":"CTL-4_R20-",
"Factors":{"Tissue":"Lung","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-4_R20-.raw"}
},
{
"Subject ID":"CTL-8",
"Sample ID":"CTL-8_R13-",
"Factors":{"Tissue":"Lung","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-8_R13-.raw"}
},
{
"Subject ID":"CTL-12",
"Sample ID":"CTL-12_R14-",
"Factors":{"Tissue":"Lung","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-12_R14-.raw"}
},
{
"Subject ID":"4T1-1",
"Sample ID":"4T1-1_R7+",
"Factors":{"Tissue":"Tibialis_anterior","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-1_R7+.raw"}
},
{
"Subject ID":"4T1-15",
"Sample ID":"4T1-15_R11+",
"Factors":{"Tissue":"Tibialis_anterior","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-15_R11+.raw"}
},
{
"Subject ID":"4T1-19",
"Sample ID":"4T1-19_R15+",
"Factors":{"Tissue":"Upper_Arm_SkM","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-19_R15+.raw"}
},
{
"Subject ID":"4T1-27",
"Sample ID":"4T1-27_R18+",
"Factors":{"Tissue":"Upper_Arm_SkM","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-27_R18+.raw"}
},
{
"Subject ID":"CTL-1",
"Sample ID":"CTL-1_R23+",
"Factors":{"Tissue":"Tibialis_anterior","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-1_R23+.raw"}
},
{
"Subject ID":"CTL-5",
"Sample ID":"CTL-5_R2+",
"Factors":{"Tissue":"Tibialis_anterior","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-5_R2+.raw"}
},
{
"Subject ID":"CTL-9",
"Sample ID":"CTL-9_R1+",
"Factors":{"Tissue":"Tibialis_anterior","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-9_R1+.raw"}
},
{
"Subject ID":"CTL-3",
"Sample ID":"CTL-3_R6+",
"Factors":{"Tissue":"Upper_Arm_SkM","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-3_R6+.raw"}
},
{
"Subject ID":"CTL-7",
"Sample ID":"CTL-7_R3+",
"Factors":{"Tissue":"Upper_Arm_SkM","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-7_R3+.raw"}
},
{
"Subject ID":"CTL-11",
"Sample ID":"CTL-11_R21+",
"Factors":{"Tissue":"Upper_Arm_SkM","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-11_R21+.raw"}
},
{
"Subject ID":"4T1-17",
"Sample ID":"4T1-17_R4+",
"Factors":{"Tissue":"Lung","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-17_R4+.raw"}
},
{
"Subject ID":"4T1-21",
"Sample ID":"4T1-21_R22+",
"Factors":{"Tissue":"Lung","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-21_R22+.raw"}
},
{
"Subject ID":"4T1-25",
"Sample ID":"4T1-25_R16+",
"Factors":{"Tissue":"Lung","Treatment":"Tumor"},
"Additional sample data":{"RAW_FILE_NAME":"4T1-25_R16+.raw"}
},
{
"Subject ID":"CTL-4",
"Sample ID":"CTL-4_R20+",
"Factors":{"Tissue":"Lung","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-4_R20+.raw"}
},
{
"Subject ID":"CTL-8",
"Sample ID":"CTL-8_R13+",
"Factors":{"Tissue":"Lung","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-8_R13+.raw"}
},
{
"Subject ID":"CTL-12",
"Sample ID":"CTL-12_R14+",
"Factors":{"Tissue":"Lung","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"CTL-12_R14+.raw"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Lung and skeletal muscle (TA and bulk muscles from the upper arm) were collected upon necropsy and imaged for mCherry+ 4T1-SkM lesions (Zeiss AxioZoom). Once a mCherry+ lesion was identified, the region was excised, leaving as little tissue margins as possible. The sample was weighed and then flash frozen using LN2. Healthy lung and skeletal muscle samples were collected through the same process, without the mCherry imaging step. 4T1-parental and 4T1-SkM cells were plated in 6-well plates at an initial density of 50,000 cells/well and collected 48h later (final density ~275,000 cells/well). Wells were washed twice with 1x PBS and cells were scraped into 1.5 mL microcentrifuge tubes and spun at 16,000 x g for 3 minutes. Samples were then flash frozen and stored at -80°C until ready to process.","SAMPLE_TYPE":"Lung"},

"TREATMENT":{"TREATMENT_SUMMARY":"Lung and skeletal muscle (TA and bulk muscles from the upper arm) were collected upon necropsy and imaged for mCherry+ 4T1-SkM lesions (Zeiss AxioZoom). Once a mCherry+ lesion was identified, the region was excised, leaving as little tissue margins as possible. The sample was weighed and then flash frozen using LN2. Healthy lung and skeletal muscle samples were collected through the same process, without the mCherry imaging step. 4T1-parental and 4T1-SkM cells were plated in 6-well plates at an initial density of 50,000 cells/well and collected 48h later (final density ~275,000 cells/well). Wells were washed twice with 1x PBS and cells were scraped into 1.5 mL microcentrifuge tubes and spun at 16,000 x g for 3 minutes. Samples were then flash frozen and stored at -80°C until ready to process."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Prior to LC-MS analysis, tissue samples were weighed and resuspended in pre-chilled (-20°C) methanol:acetonitrile:water (5:3:2, v:v) to a final concentration of 30 mg/ml, cell samples were placed on ice and re-suspended with methanol:acetonitrile:water (5:3:2, v:v) at a concentration of 2x106 cells/mL, and media samples were extracted with the same solution at a dilution of 1:25 (v/v). Suspensions were vortexed continuously for 30 min at 4°C. Insoluble material was removed by centrifugation at 18,000 g for 10 min at 4°C and supernatants were isolated for metabolomics analysis by UHPLC-MS. Analyses were performed as previously published85,86. Injection volumes for tissue, cell, and media extracts were 2 L, 10 L, and 10L, respectively. The analytical platform employs a Vanquish UHPLC system (ThermoFisher) coupled online to a Q Exactive mass spectrometer (ThermoFisher). Samples were resolved over a Kinetex C18 column, 2.1 x 150 mm, 1.7 m particle size (Phenomenex, Torrance, CA) equipped with a guard column (SecurityGuardTM Ultracartridge – UHPLC C18 for 2.1 mm ID Columns – AJO-8782 – Phenomenex, Torrance, CA) using an aqueous phase (A) of water and 0.1% formic acid and a mobile phase (B) of acetonitrile and 0.1% formic acid for positive ion polarity mode, and an aqueous phase (A) of water:acetonitrile (95:5) with 1 mM ammonium acetate, and a mobile phase (B) of acetonitrile:water (95:5) with 1 mM ammonium acetate for negative ion polarity mode. Samples were eluted from the column using either an isocratic elution of 5% B flowed at 250 L/min and 25°C or a gradient from 5% to 95% B over 1 min, followed by an isocratic hold at 95% B for 2 min, flowed at 400 L/min and 45°C. The Q Exactive mass spectrometer (ThermoFisher) was operated independently in positive or negative ion mode, scanning in Full MS mode (2 scans) from 60 to 900 m/z at 70,000 resolution, with 4 kV spray voltage, 45 sheath gas, 15 auxiliary gas. Calibration was performed prior to analysis using the PierceTM Positive and Negative Ion Calibration Solutions (ThermoFisher). Acquired data was then converted from raw to mzXML file format using Mass Matrix (Cleveland, OH). Samples were analyzed in randomized order with a technical mixture injected periodically through analysis to qualify instrument performance. Metabolite assignments, isotopologue distributions, and correction for expected natural abundances of deuterium, 13C, and 15N isotopes were performed using MAVEN (Princeton, NJ)92."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"QExactive","COLUMN_NAME":"Kinetex C18 2.1x100"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"The Q Exactive mass spectrometer (ThermoFisher) was operated independently in positive or negative ion mode, scanning in Full MS mode (2 scans) from 60 to 900 m/z at 70,000 resolution, with 4 kV spray voltage, 45 sheath gas, 15 auxiliary gas. Calibration was performed prior to analysis using the PierceTM Positive and Negative Ion Calibration Solutions (ThermoFisher). Acquired data was then converted from raw to mzXML file format using Mass Matrix (Cleveland, OH). Samples were analyzed in randomized order with a technical mixture injected periodically through analysis to qualify instrument performance. Metabolite assignments, isotopologue distributions, and correction for expected natural abundances of deuterium, 13C, and 15N isotopes were performed using MAVEN (Princeton, NJ)"},

"MS_METABOLITE_DATA":{
"Units":"AU",

"Data":[{"Metabolite":"L-alanine","4T1-1_R7+":"2.93E+07","4T1-15_R11+":"3.17E+07","4T1-19_R15+":"2.69E+07","4T1-27_R18+":"3.99E+07","CTL-1_R23+":"2.89E+07","CTL-5_R2+":"5.00E+07","CTL-9_R1+":"4.47E+07","CTL-3_R6+":"3.32E+07","CTL-7_R3+":"2.81E+07","CTL-11_R21+":"3.76E+07","4T1-17_R4+":"7.50E+06","4T1-21_R22+":"7.69E+06","4T1-25_R16+":"6.57E+06","CTL-4_R20+":"4.33E+06","CTL-8_R13+":"6.26E+06","CTL-12_R14+":"4.29E+06"},{"Metabolite":"L-arginine","4T1-1_R7+":"3.95E+06","4T1-15_R11+":"3.18E+06","4T1-19_R15+":"4.07E+06","4T1-27_R18+":"3.61E+06","CTL-1_R23+":"2.64E+06","CTL-5_R2+":"4.29E+06","CTL-9_R1+":"4.96E+06","CTL-3_R6+":"4.50E+06","CTL-7_R3+":"4.73E+06","CTL-11_R21+":"4.16E+06","4T1-17_R4+":"2.67E+06","4T1-21_R22+":"1.38E+06","4T1-25_R16+":"9.80E+05","CTL-4_R20+":"1.94E+06","CTL-8_R13+":"3.78E+06","CTL-12_R14+":"2.39E+06"},{"Metabolite":"L-asparagine","4T1-1_R7+":"2.01E+06","4T1-15_R11+":"1.94E+06","4T1-19_R15+":"2.38E+06","4T1-27_R18+":"2.31E+06","CTL-1_R23+":"1.18E+06","CTL-5_R2+":"1.52E+06","CTL-9_R1+":"1.60E+06","CTL-3_R6+":"1.47E+06","CTL-7_R3+":"1.61E+06","CTL-11_R21+":"1.64E+06","4T1-17_R4+":"9.56E+05","4T1-21_R22+":"1.38E+06","4T1-25_R16+":"8.93E+05","CTL-4_R20+":"5.74E+05","CTL-8_R13+":"8.78E+05","CTL-12_R14+":"6.34E+05"},{"Metabolite":"L-aspartate","4T1-1_R7+":"2.95E+06","4T1-15_R11+":"2.87E+06","4T1-19_R15+":"3.73E+06","4T1-27_R18+":"4.67E+06","CTL-1_R23+":"1.71E+06","CTL-5_R2+":"2.39E+06","CTL-9_R1+":"3.49E+06","CTL-3_R6+":"2.65E+06","CTL-7_R3+":"1.90E+06","CTL-11_R21+":"2.80E+06","4T1-17_R4+":"7.04E+06","4T1-21_R22+":"6.82E+06","4T1-25_R16+":"5.03E+06","CTL-4_R20+":"7.03E+06","CTL-8_R13+":"5.24E+06","CTL-12_R14+":"4.92E+06"},{"Metabolite":"L-cysteine","4T1-1_R7+":"1.37E+05","4T1-15_R11+":"3.36E+05","4T1-19_R15+":"6.96E+05","4T1-27_R18+":"5.66E+05","CTL-1_R23+":"1.41E+05","CTL-5_R2+":"1.03E+05","CTL-9_R1+":"7.18E+04","CTL-3_R6+":"1.02E+05","CTL-7_R3+":"1.30E+04","CTL-11_R21+":"1.98E+05","4T1-17_R4+":"5.90E+05","4T1-21_R22+":"5.81E+05","4T1-25_R16+":"4.81E+05","CTL-4_R20+":"1.70E+05","CTL-8_R13+":"2.28E+05","CTL-12_R14+":"5.19E+04"},{"Metabolite":"L-glutamate","4T1-1_R7+":"4.58E+07","4T1-15_R11+":"2.97E+07","4T1-19_R15+":"4.17E+07","4T1-27_R18+":"4.68E+07","CTL-1_R23+":"4.70E+07","CTL-5_R2+":"3.69E+07","CTL-9_R1+":"3.58E+07","CTL-3_R6+":"3.39E+07","CTL-7_R3+":"2.68E+07","CTL-11_R21+":"2.66E+07","4T1-17_R4+":"3.87E+07","4T1-21_R22+":"5.71E+07","4T1-25_R16+":"4.19E+07","CTL-4_R20+":"4.18E+07","CTL-8_R13+":"2.97E+07","CTL-12_R14+":"2.86E+07"},{"Metabolite":"L-glutamine","4T1-1_R7+":"5.44E+07","4T1-15_R11+":"6.21E+07","4T1-19_R15+":"7.13E+07","4T1-27_R18+":"7.17E+07","CTL-1_R23+":"8.25E+07","CTL-5_R2+":"1.07E+08","CTL-9_R1+":"8.53E+07","CTL-3_R6+":"1.02E+08","CTL-7_R3+":"9.04E+07","CTL-11_R21+":"9.00E+07","4T1-17_R4+":"1.94E+07","4T1-21_R22+":"1.15E+07","4T1-25_R16+":"1.06E+07","CTL-4_R20+":"1.24E+07","CTL-8_R13+":"1.12E+07","CTL-12_R14+":"6.65E+06"},{"Metabolite":"glycine","4T1-1_R7+":"5.99E+06","4T1-15_R11+":"7.25E+06","4T1-19_R15+":"6.07E+06","4T1-27_R18+":"6.06E+06","CTL-1_R23+":"5.62E+06","CTL-5_R2+":"6.29E+06","CTL-9_R1+":"5.67E+06","CTL-3_R6+":"8.70E+06","CTL-7_R3+":"7.45E+06","CTL-11_R21+":"9.92E+06","4T1-17_R4+":"1.04E+07","4T1-21_R22+":"7.58E+06","4T1-25_R16+":"5.84E+06","CTL-4_R20+":"6.05E+06","CTL-8_R13+":"7.49E+06","CTL-12_R14+":"7.18E+06"},{"Metabolite":"L-histidine","4T1-1_R7+":"1.46E+07","4T1-15_R11+":"1.17E+07","4T1-19_R15+":"7.64E+06","4T1-27_R18+":"1.01E+07","CTL-1_R23+":"1.58E+07","CTL-5_R2+":"1.60E+07","CTL-9_R1+":"1.51E+07","CTL-3_R6+":"1.59E+07","CTL-7_R3+":"1.46E+07","CTL-11_R21+":"1.56E+07","4T1-17_R4+":"2.86E+06","4T1-21_R22+":"2.34E+06","4T1-25_R16+":"1.99E+06","CTL-4_R20+":"1.57E+06","CTL-8_R13+":"2.45E+06","CTL-12_R14+":"1.30E+06"},{"Metabolite":"L-leucine","4T1-1_R7+":"1.63E+07","4T1-15_R11+":"1.78E+07","4T1-19_R15+":"2.17E+07","4T1-27_R18+":"1.52E+07","CTL-1_R23+":"1.27E+07","CTL-5_R2+":"1.70E+07","CTL-9_R1+":"1.46E+07","CTL-3_R6+":"9.60E+06","CTL-7_R3+":"1.20E+07","CTL-11_R21+":"1.12E+07","4T1-17_R4+":"9.67E+06","4T1-21_R22+":"1.37E+07","4T1-25_R16+":"1.32E+07","CTL-4_R20+":"9.96E+06","CTL-8_R13+":"1.33E+07","CTL-12_R14+":"9.57E+06"},{"Metabolite":"L-lysine","4T1-1_R7+":"1.89E+07","4T1-15_R11+":"1.26E+07","4T1-19_R15+":"1.50E+07","4T1-27_R18+":"1.45E+07","CTL-1_R23+":"1.73E+07","CTL-5_R2+":"2.12E+07","CTL-9_R1+":"2.80E+07","CTL-3_R6+":"2.25E+07","CTL-7_R3+":"2.41E+07","CTL-11_R21+":"2.64E+07","4T1-17_R4+":"7.40E+06","4T1-21_R22+":"5.04E+06","4T1-25_R16+":"5.73E+06","CTL-4_R20+":"4.64E+06","CTL-8_R13+":"8.76E+06","CTL-12_R14+":"5.27E+06"},{"Metabolite":"L-methionine","4T1-1_R7+":"1.94E+07","4T1-15_R11+":"1.61E+07","4T1-19_R15+":"1.41E+07","4T1-27_R18+":"1.72E+07","CTL-1_R23+":"9.57E+06","CTL-5_R2+":"1.58E+07","CTL-9_R1+":"2.20E+07","CTL-3_R6+":"1.32E+07","CTL-7_R3+":"1.20E+07","CTL-11_R21+":"1.75E+07","4T1-17_R4+":"1.10E+07","4T1-21_R22+":"1.07E+07","4T1-25_R16+":"1.01E+07","CTL-4_R20+":"4.76E+06","CTL-8_R13+":"9.74E+06","CTL-12_R14+":"6.14E+06"},{"Metabolite":"L-phenylalanine","4T1-1_R7+":"8.80E+06","4T1-15_R11+":"8.24E+06","4T1-19_R15+":"1.05E+07","4T1-27_R18+":"9.14E+06","CTL-1_R23+":"5.15E+06","CTL-5_R2+":"8.16E+06","CTL-9_R1+":"1.01E+07","CTL-3_R6+":"4.58E+06","CTL-7_R3+":"6.05E+06","CTL-11_R21+":"4.35E+06","4T1-17_R4+":"4.81E+06","4T1-21_R22+":"6.61E+06","4T1-25_R16+":"5.94E+06","CTL-4_R20+":"3.09E+06","CTL-8_R13+":"5.13E+06","CTL-12_R14+":"3.16E+06"},{"Metabolite":"L-proline","4T1-1_R7+":"4.83E+07","4T1-15_R11+":"4.30E+07","4T1-19_R15+":"5.13E+07","4T1-27_R18+":"4.35E+07","CTL-1_R23+":"1.60E+07","CTL-5_R2+":"2.22E+07","CTL-9_R1+":"2.76E+07","CTL-3_R6+":"2.01E+07","CTL-7_R3+":"2.18E+07","CTL-11_R21+":"2.17E+07","4T1-17_R4+":"1.48E+07","4T1-21_R22+":"2.09E+07","4T1-25_R16+":"2.44E+07","CTL-4_R20+":"8.78E+06","CTL-8_R13+":"1.82E+07","CTL-12_R14+":"1.28E+07"},{"Metabolite":"L-serine","4T1-1_R7+":"2.47E+06","4T1-15_R11+":"2.61E+06","4T1-19_R15+":"3.03E+06","4T1-27_R18+":"2.78E+06","CTL-1_R23+":"2.78E+06","CTL-5_R2+":"3.09E+06","CTL-9_R1+":"2.56E+06","CTL-3_R6+":"3.44E+06","CTL-7_R3+":"2.64E+06","CTL-11_R21+":"3.18E+06","4T1-17_R4+":"1.35E+06","4T1-21_R22+":"1.83E+06","4T1-25_R16+":"1.25E+06","CTL-4_R20+":"9.44E+05","CTL-8_R13+":"1.55E+06","CTL-12_R14+":"1.10E+06"},{"Metabolite":"L-threonine","4T1-1_R7+":"7.40E+06","4T1-15_R11+":"9.81E+06","4T1-19_R15+":"7.13E+06","4T1-27_R18+":"1.06E+07","CTL-1_R23+":"7.21E+06","CTL-5_R2+":"9.68E+06","CTL-9_R1+":"7.63E+06","CTL-3_R6+":"6.36E+06","CTL-7_R3+":"8.58E+06","CTL-11_R21+":"7.51E+06","4T1-17_R4+":"3.63E+06","4T1-21_R22+":"3.86E+06","4T1-25_R16+":"3.97E+06","CTL-4_R20+":"2.10E+06","CTL-8_R13+":"3.48E+06","CTL-12_R14+":"2.06E+06"},{"Metabolite":"L-tryptophan","4T1-1_R7+":"2.66E+07","4T1-15_R11+":"2.03E+07","4T1-19_R15+":"2.37E+07","4T1-27_R18+":"1.88E+07","CTL-1_R23+":"8.52E+06","CTL-5_R2+":"9.61E+06","CTL-9_R1+":"1.40E+07","CTL-3_R6+":"5.64E+06","CTL-7_R3+":"9.68E+06","CTL-11_R21+":"8.01E+06","4T1-17_R4+":"2.34E+07","4T1-21_R22+":"1.24E+07","4T1-25_R16+":"1.21E+07","CTL-4_R20+":"1.02E+07","CTL-8_R13+":"1.65E+07","CTL-12_R14+":"8.19E+06"},{"Metabolite":"L-tyrosine","4T1-1_R7+":"1.37E+07","4T1-15_R11+":"1.02E+07","4T1-19_R15+":"1.17E+07","4T1-27_R18+":"9.44E+06","CTL-1_R23+":"4.68E+06","CTL-5_R2+":"9.42E+06","CTL-9_R1+":"1.11E+07","CTL-3_R6+":"6.49E+06","CTL-7_R3+":"6.36E+06","CTL-11_R21+":"8.56E+06","4T1-17_R4+":"9.08E+06","4T1-21_R22+":"8.78E+06","4T1-25_R16+":"6.19E+06","CTL-4_R20+":"2.94E+06","CTL-8_R13+":"5.83E+06","CTL-12_R14+":"4.06E+06"},{"Metabolite":"L-valine","4T1-1_R7+":"3.91E+07","4T1-15_R11+":"3.25E+07","4T1-19_R15+":"4.55E+07","4T1-27_R18+":"3.65E+07","CTL-1_R23+":"2.39E+07","CTL-5_R2+":"3.89E+07","CTL-9_R1+":"3.26E+07","CTL-3_R6+":"2.87E+07","CTL-7_R3+":"3.61E+07","CTL-11_R21+":"2.70E+07","4T1-17_R4+":"2.42E+07","4T1-21_R22+":"2.54E+07","4T1-25_R16+":"1.93E+07","CTL-4_R20+":"1.71E+07","CTL-8_R13+":"2.22E+07","CTL-12_R14+":"1.69E+07"},{"Metabolite":"L-cystine","4T1-1_R7+":"7.99E+03","4T1-15_R11+":"0.00E+00","4T1-19_R15+":"3.27E+03","4T1-27_R18+":"0.00E+00","CTL-1_R23+":"2.18E+04","CTL-5_R2+":"0.00E+00","CTL-9_R1+":"0.00E+00","CTL-3_R6+":"0.00E+00","CTL-7_R3+":"0.00E+00","CTL-11_R21+":"0.00E+00","4T1-17_R4+":"6.31E+03","4T1-21_R22+":"0.00E+00","4T1-25_R16+":"6.01E+03","CTL-4_R20+":"1.80E+04","CTL-8_R13+":"1.43E+04","CTL-12_R14+":"1.33E+04"},{"Metabolite":"AMP","4T1-1_R7+":"5.12E+06","4T1-15_R11+":"5.45E+06","4T1-19_R15+":"1.45E+06","4T1-27_R18+":"4.14E+06","CTL-1_R23+":"3.14E+06","CTL-5_R2+":"1.56E+06","CTL-9_R1+":"4.21E+06","CTL-3_R6+":"2.50E+06","CTL-7_R3+":"1.35E+06","CTL-11_R21+":"4.62E+06","4T1-17_R4+":"2.54E+07","4T1-21_R22+":"2.51E+07","4T1-25_R16+":"1.83E+07","CTL-4_R20+":"3.22E+07","CTL-8_R13+":"1.17E+07","CTL-12_R14+":"1.86E+07"},{"Metabolite":"dAMP","4T1-1_R7+":"0.00E+00","4T1-15_R11+":"0.00E+00","4T1-19_R15+":"1.44E+04","4T1-27_R18+":"0.00E+00","CTL-1_R23+":"3.89E+03","CTL-5_R2+":"0.00E+00","CTL-9_R1+":"0.00E+00","CTL-3_R6+":"0.00E+00","CTL-7_R3+":"6.87E+03","CTL-11_R21+":"1.98E+03","4T1-17_R4+":"6.71E+03","4T1-21_R22+":"7.06E+04","4T1-25_R16+":"3.45E+04","CTL-4_R20+":"1.75E+04","CTL-8_R13+":"9.29E+03","CTL-12_R14+":"6.81E+03"},{"Metabolite":"Adenosine","4T1-1_R7+":"3.15E+06","4T1-15_R11+":"1.54E+06","4T1-19_R15+":"2.85E+06","4T1-27_R18+":"2.42E+06","CTL-1_R23+":"5.04E+05","CTL-5_R2+":"6.18E+05","CTL-9_R1+":"2.64E+05","CTL-3_R6+":"6.73E+05","CTL-7_R3+":"2.45E+05","CTL-11_R21+":"3.01E+05","4T1-17_R4+":"2.44E+07","4T1-21_R22+":"8.05E+06","4T1-25_R16+":"6.42E+06","CTL-4_R20+":"2.36E+07","CTL-8_R13+":"1.12E+07","CTL-12_R14+":"6.61E+06"},{"Metabolite":"Adenine","4T1-1_R7+":"8.17E+05","4T1-15_R11+":"3.65E+05","4T1-19_R15+":"2.61E+05","4T1-27_R18+":"4.79E+05","CTL-1_R23+":"2.03E+05","CTL-5_R2+":"2.21E+05","CTL-9_R1+":"2.73E+05","CTL-3_R6+":"2.65E+05","CTL-7_R3+":"2.55E+05","CTL-11_R21+":"2.21E+05","4T1-17_R4+":"1.66E+06","4T1-21_R22+":"1.08E+06","4T1-25_R16+":"6.77E+05","CTL-4_R20+":"1.52E+06","CTL-8_R13+":"8.65E+05","CTL-12_R14+":"6.94E+05"},{"Metabolite":"GMP","4T1-1_R7+":"1.14E+06","4T1-15_R11+":"4.85E+05","4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","CTL-5_R2+":"2.89E+07","CTL-9_R1+":"2.43E+07","CTL-3_R6+":"2.91E+07","CTL-7_R3+":"2.63E+07","CTL-11_R21+":"2.32E+07","4T1-17_R4+":"2.45E+07","4T1-21_R22+":"4.75E+07","4T1-25_R16+":"4.10E+07","CTL-4_R20+":"2.64E+07","CTL-8_R13+":"4.85E+07","CTL-12_R14+":"5.04E+07"},{"Metabolite":"Xanthosine","4T1-1_R7+":"2.13E+03","4T1-15_R11+":"0.00E+00","4T1-19_R15+":"1.49E+04","4T1-27_R18+":"8.06E+03","CTL-1_R23+":"0.00E+00","CTL-5_R2+":"2.23E+03","CTL-9_R1+":"2.10E+03","CTL-3_R6+":"0.00E+00","CTL-7_R3+":"0.00E+00","CTL-11_R21+":"0.00E+00","4T1-17_R4+":"5.56E+03","4T1-21_R22+":"1.94E+04","4T1-25_R16+":"1.90E+04","CTL-4_R20+":"4.32E+03","CTL-8_R13+":"9.03E+03","CTL-12_R14+":"8.16E+03"},{"Metabolite":"Xanthine","4T1-1_R7+":"1.43E+06","4T1-15_R11+":"8.89E+05","4T1-19_R15+":"3.65E+06","4T1-27_R18+":"2.49E+06","CTL-1_R23+":"1.01E+06","CTL-5_R2+":"1.39E+06","CTL-9_R1+":"1.48E+06","CTL-3_R6+":"1.06E+06","CTL-7_R3+":"9.21E+05","CTL-11_R21+":"1.03E+06","4T1-17_R4+":"1.93E+06","4T1-21_R22+":"3.75E+06","4T1-25_R16+":"2.75E+06","CTL-4_R20+":"1.76E+06","CTL-8_R13+":"2.37E+06","CTL-12_R14+":"2.90E+06"},{"Metabolite":"Urate","4T1-1_R7+":"4.42E+05","4T1-15_R11+":"2.97E+05","4T1-19_R15+":"9.64E+05","4T1-27_R18+":"3.60E+05","CTL-1_R23+":"3.54E+05","CTL-5_R2+":"5.49E+05","CTL-9_R1+":"3.66E+05","CTL-3_R6+":"2.59E+05","CTL-7_R3+":"2.84E+05","CTL-11_R21+":"2.77E+05","4T1-17_R4+":"2.09E+06","4T1-21_R22+":"2.20E+06","4T1-25_R16+":"2.01E+06","CTL-4_R20+":"1.36E+06","CTL-8_R13+":"1.15E+06","CTL-12_R14+":"1.29E+06"},{"Metabolite":"5-Hydroxyisourate","4T1-1_R7+":"1.33E+06","4T1-15_R11+":"2.60E+06","4T1-19_R15+":"3.08E+06","4T1-27_R18+":"3.63E+06","CTL-1_R23+":"4.27E+06","CTL-5_R2+":"2.76E+06","CTL-9_R1+":"2.39E+06","CTL-3_R6+":"2.86E+06","CTL-7_R3+":"3.85E+06","CTL-11_R21+":"3.47E+06","4T1-17_R4+":"1.59E+06","4T1-21_R22+":"9.57E+05","4T1-25_R16+":"6.76E+05","CTL-4_R20+":"8.54E+04","CTL-8_R13+":"4.70E+05","CTL-12_R14+":"2.58E+04"},{"Metabolite":"(S)(+)-Allantoin","4T1-1_R7+":"3.95E+05","4T1-15_R11+":"3.23E+05","4T1-19_R15+":"4.28E+05","4T1-27_R18+":"3.23E+05","CTL-1_R23+":"4.07E+05","CTL-5_R2+":"2.97E+05","CTL-9_R1+":"3.59E+05","CTL-3_R6+":"4.33E+05","CTL-7_R3+":"3.27E+05","CTL-11_R21+":"3.05E+05","4T1-17_R4+":"3.48E+05","4T1-21_R22+":"2.25E+05","4T1-25_R16+":"2.82E+05","CTL-4_R20+":"2.76E+05","CTL-8_R13+":"3.99E+05","CTL-12_R14+":"2.12E+05"},{"Metabolite":"Allantoate","4T1-1_R7+":"4.08E+04","4T1-15_R11+":"2.30E+04","4T1-19_R15+":"6.82E+04","4T1-27_R18+":"3.24E+04","CTL-1_R23+":"0.00E+00","CTL-5_R2+":"3.07E+04","CTL-9_R1+":"2.84E+04","CTL-3_R6+":"1.29E+04","CTL-7_R3+":"2.30E+04","CTL-11_R21+":"1.81E+04","4T1-17_R4+":"1.35E+05","4T1-21_R22+":"2.65E+05","4T1-25_R16+":"4.08E+05","CTL-4_R20+":"6.89E+04","CTL-8_R13+":"1.72E+05","CTL-12_R14+":"7.78E+04"},{"Metabolite":"3',5'-Cyclic IMP","4T1-1_R7+":"1.61E+04","4T1-15_R11+":"1.07E+04","4T1-19_R15+":"1.91E+04","4T1-27_R18+":"1.49E+04","CTL-1_R23+":"2.00E+04","CTL-5_R2+":"1.71E+04","CTL-9_R1+":"6.66E+03","CTL-3_R6+":"1.06E+04","CTL-7_R3+":"3.67E+03","CTL-11_R21+":"1.93E+04","4T1-17_R4+":"0.00E+00","4T1-21_R22+":"0.00E+00","4T1-25_R16+":"0.00E+00","CTL-4_R20+":"0.00E+00","CTL-8_R13+":"2.26E+03","CTL-12_R14+":"0.00E+00"},{"Metabolite":"Adenylyl sulfate","4T1-1_R7+":"1.40E+05","4T1-15_R11+":"1.14E+05","4T1-19_R15+":"1.31E+05","4T1-27_R18+":"1.32E+05","CTL-1_R23+":"1.48E+05","CTL-5_R2+":"1.25E+05","CTL-9_R1+":"1.24E+05","CTL-3_R6+":"1.35E+05","CTL-7_R3+":"1.45E+05","CTL-11_R21+":"1.59E+05","4T1-17_R4+":"2.14E+04","4T1-21_R22+":"3.84E+04","4T1-25_R16+":"4.12E+04","CTL-4_R20+":"2.23E+03","CTL-8_R13+":"9.92E+03","CTL-12_R14+":"0.00E+00"},{"Metabolite":"Pyridoxal","4T1-1_R7+":"5.37E+04","4T1-15_R11+":"1.64E+04","4T1-19_R15+":"3.56E+04","4T1-27_R18+":"7.57E+04","CTL-1_R23+":"3.09E+03","CTL-5_R2+":"1.68E+04","CTL-9_R1+":"2.95E+03","CTL-3_R6+":"1.83E+04","CTL-7_R3+":"2.97E+03","CTL-11_R21+":"8.18E+03","4T1-17_R4+":"3.18E+04","4T1-21_R22+":"1.96E+04","4T1-25_R16+":"9.53E+03","CTL-4_R20+":"2.42E+04","CTL-8_R13+":"2.82E+04","CTL-12_R14+":"1.04E+04"},{"Metabolite":"Nicotinamide","4T1-1_R7+":"8.90E+07","4T1-15_R11+":"5.58E+07","4T1-19_R15+":"4.60E+07","4T1-27_R18+":"6.27E+07","CTL-1_R23+":"8.70E+07","CTL-5_R2+":"7.81E+07","CTL-9_R1+":"1.02E+08","CTL-3_R6+":"6.62E+07","CTL-7_R3+":"5.85E+07","CTL-11_R21+":"5.97E+07","4T1-17_R4+":"2.35E+07","4T1-21_R22+":"2.42E+07","4T1-25_R16+":"1.97E+07","CTL-4_R20+":"1.83E+07","CTL-8_R13+":"1.48E+07","CTL-12_R14+":"2.10E+07"},{"Metabolite":"Nicotinate ribonucleotide","4T1-1_R7+":"3.55E+03","4T1-15_R11+":"1.45E+05","4T1-19_R15+":"0.00E+00","4T1-27_R18+":"4.38E+03","CTL-1_R23+":"0.00E+00","CTL-5_R2+":"0.00E+00","CTL-9_R1+":"6.23E+03","CTL-3_R6+":"2.74E+04","CTL-7_R3+":"2.81E+04","CTL-11_R21+":"0.00E+00","4T1-17_R4+":"5.01E+03","4T1-21_R22+":"0.00E+00","4T1-25_R16+":"0.00E+00","CTL-4_R20+":"0.00E+00","CTL-8_R13+":"0.00E+00","CTL-12_R14+":"0.00E+00"},{"Metabolite":"NADPH","4T1-1_R7+":"3.26E+04","4T1-15_R11+":"4.45E+04","4T1-19_R15+":"6.61E+04","4T1-27_R18+":"0.00E+00","CTL-1_R23+":"5.75E+04","CTL-5_R2+":"2.22E+04","CTL-9_R1+":"4.46E+04","CTL-3_R6+":"3.04E+04","CTL-7_R3+":"0.00E+00","CTL-11_R21+":"2.18E+04","4T1-17_R4+":"0.00E+00","4T1-21_R22+":"0.00E+00","4T1-25_R16+":"0.00E+00","CTL-4_R20+":"0.00E+00","CTL-8_R13+":"0.00E+00","CTL-12_R14+":"0.00E+00"},{"Metabolite":"NADH","4T1-1_R7+":"1.84E+04","4T1-15_R11+":"1.17E+04","4T1-19_R15+":"0.00E+00","4T1-27_R18+":"0.00E+00","CTL-1_R23+":"1.38E+03","CTL-5_R2+":"4.77E+03","CTL-9_R1+":"2.42E+03","CTL-3_R6+":"7.77E+03","CTL-7_R3+":"4.35E+03","CTL-11_R21+":"2.30E+03","4T1-17_R4+":"0.00E+00","4T1-21_R22+":"0.00E+00","4T1-25_R16+":"0.00E+00","CTL-4_R20+":"0.00E+00","CTL-8_R13+":"0.00E+00","CTL-12_R14+":"0.00E+00"},{"Metabolite":"Glutathione","4T1-1_R7+":"6.16E+07","4T1-15_R11+":"3.65E+07","4T1-19_R15+":"4.60E+07","4T1-27_R18+":"4.92E+07","CTL-1_R23+":"5.42E+07","CTL-5_R2+":"7.02E+07","CTL-9_R1+":"5.18E+07","CTL-3_R6+":"6.61E+07","CTL-7_R3+":"5.91E+07","CTL-11_R21+":"5.12E+07","4T1-17_R4+":"6.81E+07","4T1-21_R22+":"8.95E+07","4T1-25_R16+":"4.82E+07","CTL-4_R20+":"3.61E+07","CTL-8_R13+":"2.14E+07","CTL-12_R14+":"3.64E+07"},{"Metabolite":"Glutathione disulfide","4T1-1_R7+":"8.22E+05","4T1-15_R11+":"6.91E+05","4T1-19_R15+":"8.36E+05","4T1-27_R18+":"6.46E+05","CTL-1_R23+":"4.18E+05","CTL-5_R2+":"8.07E+05","CTL-9_R1+":"4.68E+05","CTL-3_R6+":"4.88E+05","CTL-7_R3+":"5.25E+05","CTL-11_R21+":"2.71E+05","4T1-17_R4+":"3.27E+06","4T1-21_R22+":"1.76E+06","4T1-25_R16+":"1.62E+06","CTL-4_R20+":"3.18E+06","CTL-8_R13+":"2.52E+06","CTL-12_R14+":"3.28E+06"},{"Metabolite":"5-Oxoproline","4T1-1_R7+":"3.48E+07","4T1-15_R11+":"3.45E+07","4T1-19_R15+":"3.98E+07","4T1-27_R18+":"4.42E+07","CTL-1_R23+":"4.89E+07","CTL-5_R2+":"4.38E+07","CTL-9_R1+":"5.06E+07","CTL-3_R6+":"6.02E+07","CTL-7_R3+":"5.23E+07","CTL-11_R21+":"5.22E+07","4T1-17_R4+":"1.67E+07","4T1-21_R22+":"1.52E+07","4T1-25_R16+":"1.33E+07","CTL-4_R20+":"1.28E+07","CTL-8_R13+":"1.10E+07","CTL-12_R14+":"7.76E+06"},{"Metabolite":"S-Glutathionyl-L-cysteine","4T1-1_R7+":"4.74E+04","4T1-15_R11+":"8.00E+04","4T1-19_R15+":"1.77E+05","4T1-27_R18+":"3.57E+04","CTL-1_R23+":"0.00E+00","CTL-5_R2+":"2.64E+04","CTL-9_R1+":"4.58E+04","CTL-3_R6+":"0.00E+00","CTL-7_R3+":"0.00E+00","CTL-11_R21+":"1.24E+04","4T1-17_R4+":"2.94E+05","4T1-21_R22+":"2.67E+05","4T1-25_R16+":"2.51E+05","CTL-4_R20+":"3.75E+05","CTL-8_R13+":"5.49E+05","CTL-12_R14+":"4.03E+05"},{"Metabolite":"Cys-Gly","4T1-1_R7+":"4.47E+05","4T1-15_R11+":"2.59E+05","4T1-19_R15+":"2.73E+05","4T1-27_R18+":"3.34E+05","CTL-1_R23+":"3.94E+05","CTL-5_R2+":"4.56E+05","CTL-9_R1+":"3.70E+05","CTL-3_R6+":"4.84E+05","CTL-7_R3+":"4.18E+05","CTL-11_R21+":"3.66E+05","4T1-17_R4+":"4.85E+05","4T1-21_R22+":"6.68E+05","4T1-25_R16+":"3.12E+05","CTL-4_R20+":"2.94E+05","CTL-8_R13+":"1.92E+05","CTL-12_R14+":"2.56E+05"},{"Metabolite":"Ascorbate","4T1-1_R7+":"6.03E+05","4T1-15_R11+":"4.94E+05","4T1-19_R15+":"7.84E+05","4T1-27_R18+":"6.39E+05","CTL-1_R23+":"5.05E+05","CTL-5_R2+":"5.61E+05","CTL-9_R1+":"4.00E+05","CTL-3_R6+":"5.98E+05","CTL-7_R3+":"5.37E+05","CTL-11_R21+":"4.32E+05","4T1-17_R4+":"3.82E+06","4T1-21_R22+":"2.16E+06","4T1-25_R16+":"9.82E+05","CTL-4_R20+":"1.72E+06","CTL-8_R13+":"5.17E+05","CTL-12_R14+":"8.02E+05"},{"Metabolite":"Dehydroascorbate","4T1-1_R7+":"2.06E+04","4T1-15_R11+":"1.35E+04","4T1-19_R15+":"3.59E+04","4T1-27_R18+":"3.13E+04","CTL-1_R23+":"3.14E+04","CTL-5_R2+":"3.01E+04","CTL-9_R1+":"2.34E+04","CTL-3_R6+":"2.13E+04","CTL-7_R3+":"1.42E+04","CTL-11_R21+":"1.98E+04","4T1-17_R4+":"6.00E+04","4T1-21_R22+":"4.84E+04","4T1-25_R16+":"2.60E+04","CTL-4_R20+":"4.62E+04","CTL-8_R13+":"3.64E+04","CTL-12_R14+":"4.44E+04"},{"Metabolite":"gamma-L-Glutamyl-D-alanine","4T1-1_R7+":"8.47E+04","4T1-15_R11+":"6.71E+04","4T1-19_R15+":"9.12E+04","4T1-27_R18+":"5.67E+04","CTL-1_R23+":"1.03E+05","CTL-5_R2+":"1.03E+05","CTL-9_R1+":"9.22E+04","CTL-3_R6+":"5.54E+04","CTL-7_R3+":"8.53E+04","CTL-11_R21+":"6.39E+04","4T1-17_R4+":"2.57E+05","4T1-21_R22+":"7.58E+04","4T1-25_R16+":"7.26E+04","CTL-4_R20+":"1.13E+05","CTL-8_R13+":"2.05E+05","CTL-12_R14+":"1.36E+05"},{"Metabolite":"gamma-Glutamyl-gamma-aminobutyrate","4T1-1_R7+":"1.09E+05","4T1-15_R11+":"7.57E+04","4T1-19_R15+":"1.02E+05","4T1-27_R18+":"1.00E+05","CTL-1_R23+":"1.40E+05","CTL-5_R2+":"1.41E+05","CTL-9_R1+":"1.21E+05","CTL-3_R6+":"1.35E+05","CTL-7_R3+":"8.41E+04","CTL-11_R21+":"8.40E+04","4T1-17_R4+":"4.06E+04","4T1-21_R22+":"9.89E+04","4T1-25_R16+":"3.67E+04","CTL-4_R20+":"3.04E+04","CTL-8_R13+":"3.73E+04","CTL-12_R14+":"2.09E+04"},{"Metabolite":"gamma-L-Glutamylputrescine","4T1-1_R7+":"1.35E+05","4T1-15_R11+":"1.08E+05","4T1-19_R15+":"1.36E+05","4T1-27_R18+":"9.64E+04","CTL-1_R23+":"1.24E+05","CTL-5_R2+":"1.33E+05","CTL-9_R1+":"1.14E+05","CTL-3_R6+":"1.04E+05","CTL-7_R3+":"7.57E+04","CTL-11_R21+":"4.23E+04","4T1-17_R4+":"1.69E+04","4T1-21_R22+":"2.15E+04","4T1-25_R16+":"4.02E+04","CTL-4_R20+":"3.18E+03","CTL-8_R13+":"2.30E+03","CTL-12_R14+":"0.00E+00"},{"Metabolite":"(5-L-Glutamyl)-L-glutamine","4T1-1_R7+":"5.77E+04","4T1-15_R11+":"9.79E+04","4T1-19_R15+":"1.00E+05","4T1-27_R18+":"0.00E+00","CTL-1_R23+":"3.50E+04","CTL-5_R2+":"2.43E+04","CTL-9_R1+":"1.72E+04","CTL-3_R6+":"7.99E+03","CTL-7_R3+":"4.28E+03","CTL-11_R21+":"7.80E+03","4T1-17_R4+":"3.69E+05","4T1-21_R22+":"1.72E+05","4T1-25_R16+":"1.37E+05","CTL-4_R20+":"2.23E+05","CTL-8_R13+":"2.62E+05","CTL-12_R14+":"1.40E+05"},{"Metabolite":"L-Homocysteine","4T1-1_R7+":"9.67E+04","4T1-15_R11+":"4.05E+04","4T1-19_R15+":"5.24E+04","4T1-27_R18+":"3.40E+04","CTL-1_R23+":"5.09E+04","CTL-5_R2+":"4.72E+04","CTL-9_R1+":"3.75E+04","CTL-3_R6+":"4.17E+04","CTL-7_R3+":"3.01E+04","CTL-11_R21+":"6.85E+04","4T1-17_R4+":"5.14E+04","4T1-21_R22+":"5.32E+04","4T1-25_R16+":"2.39E+04","CTL-4_R20+":"3.23E+04","CTL-8_R13+":"2.71E+04","CTL-12_R14+":"1.93E+04"},{"Metabolite":"Phosphoserine","4T1-1_R7+":"8.94E+04","4T1-15_R11+":"3.43E+04","4T1-19_R15+":"7.27E+04","4T1-27_R18+":"4.44E+04","CTL-1_R23+":"3.96E+04","CTL-5_R2+":"1.97E+04","CTL-9_R1+":"4.52E+04","CTL-3_R6+":"4.01E+04","CTL-7_R3+":"1.60E+04","CTL-11_R21+":"1.04E+04","4T1-17_R4+":"1.84E+05","4T1-21_R22+":"3.05E+05","4T1-25_R16+":"2.25E+05","CTL-4_R20+":"1.87E+05","CTL-8_R13+":"1.84E+05","CTL-12_R14+":"1.05E+05"},{"Metabolite":"S-Adenosyl-L-homocysteine","4T1-1_R7+":"1.17E+05","4T1-15_R11+":"9.39E+04","4T1-19_R15+":"2.35E+05","4T1-27_R18+":"2.04E+05","CTL-1_R23+":"1.68E+05","CTL-5_R2+":"1.97E+05","CTL-9_R1+":"1.36E+05","CTL-3_R6+":"1.37E+05","CTL-7_R3+":"1.31E+05","CTL-11_R21+":"1.32E+05","4T1-17_R4+":"3.69E+05","4T1-21_R22+":"3.95E+05","4T1-25_R16+":"3.17E+05","CTL-4_R20+":"2.66E+05","CTL-8_R13+":"2.82E+05","CTL-12_R14+":"4.00E+05"},{"Metabolite":"S-Adenosyl-L-methionine","4T1-1_R7+":"2.14E+05","4T1-15_R11+":"1.82E+05","4T1-19_R15+":"1.64E+05","4T1-27_R18+":"2.09E+05","CTL-1_R23+":"2.65E+05","CTL-5_R2+":"2.29E+05","CTL-9_R1+":"1.94E+05","CTL-3_R6+":"1.91E+05","CTL-7_R3+":"1.75E+05","CTL-11_R21+":"2.38E+05","4T1-17_R4+":"2.12E+05","4T1-21_R22+":"2.95E+05","4T1-25_R16+":"2.14E+05","CTL-4_R20+":"2.10E+05","CTL-8_R13+":"1.76E+05","CTL-12_R14+":"1.75E+05"},{"Metabolite":"Ornithine","4T1-1_R7+":"9.31E+05","4T1-15_R11+":"1.05E+06","4T1-19_R15+":"1.04E+06","4T1-27_R18+":"6.98E+05","CTL-1_R23+":"7.14E+05","CTL-5_R2+":"1.23E+06","CTL-9_R1+":"1.53E+06","CTL-3_R6+":"7.09E+05","CTL-7_R3+":"1.04E+06","CTL-11_R21+":"1.26E+06","4T1-17_R4+":"7.73E+05","4T1-21_R22+":"1.32E+06","4T1-25_R16+":"1.74E+06","CTL-4_R20+":"2.88E+05","CTL-8_R13+":"8.46E+05","CTL-12_R14+":"4.34E+05"},{"Metabolite":"L-Citrulline","4T1-1_R7+":"7.76E+06","4T1-15_R11+":"8.18E+06","4T1-19_R15+":"4.88E+06","4T1-27_R18+":"7.06E+06","CTL-1_R23+":"9.53E+06","CTL-5_R2+":"1.01E+07","CTL-9_R1+":"8.04E+06","CTL-3_R6+":"8.32E+06","CTL-7_R3+":"8.45E+06","CTL-11_R21+":"9.20E+06","4T1-17_R4+":"2.06E+06","4T1-21_R22+":"1.85E+06","4T1-25_R16+":"1.82E+06","CTL-4_R20+":"1.58E+06","CTL-8_R13+":"2.15E+06","CTL-12_R14+":"1.08E+06"},{"Metabolite":"Argininosuccinate","4T1-1_R7+":"3.28E+04","4T1-15_R11+":"2.33E+04","4T1-19_R15+":"6.58E+04","4T1-27_R18+":"7.85E+04","CTL-1_R23+":"2.74E+04","CTL-5_R2+":"3.48E+04","CTL-9_R1+":"2.02E+04","CTL-3_R6+":"3.68E+04","CTL-7_R3+":"1.78E+04","CTL-11_R21+":"3.51E+04","4T1-17_R4+":"2.60E+04","4T1-21_R22+":"3.32E+04","4T1-25_R16+":"2.22E+04","CTL-4_R20+":"9.48E+03","CTL-8_R13+":"2.75E+04","CTL-12_R14+":"1.48E+04"},{"Metabolite":"5-Methylthioadenosine","4T1-1_R7+":"4.53E+05","4T1-15_R11+":"4.16E+05","4T1-19_R15+":"2.38E+05","4T1-27_R18+":"2.91E+05","CTL-1_R23+":"2.25E+05","CTL-5_R2+":"2.25E+05","CTL-9_R1+":"2.51E+05","CTL-3_R6+":"2.67E+05","CTL-7_R3+":"2.47E+05","CTL-11_R21+":"2.04E+05","4T1-17_R4+":"1.02E+06","4T1-21_R22+":"9.91E+05","4T1-25_R16+":"6.55E+05","CTL-4_R20+":"6.18E+05","CTL-8_R13+":"5.04E+05","CTL-12_R14+":"5.47E+05"},{"Metabolite":"Putrescine","4T1-1_R7+":"1.59E+05","4T1-15_R11+":"1.07E+05","4T1-19_R15+":"5.69E+04","4T1-27_R18+":"1.25E+05","CTL-1_R23+":"6.51E+04","CTL-5_R2+":"5.57E+04","CTL-9_R1+":"5.66E+04","CTL-3_R6+":"4.40E+04","CTL-7_R3+":"5.02E+04","CTL-11_R21+":"5.56E+04","4T1-17_R4+":"2.01E+05","4T1-21_R22+":"3.16E+05","4T1-25_R16+":"1.81E+05","CTL-4_R20+":"8.87E+04","CTL-8_R13+":"7.23E+04","CTL-12_R14+":"9.95E+04"},{"Metabolite":"Spermidine","4T1-1_R7+":"9.38E+05","4T1-15_R11+":"1.23E+06","4T1-19_R15+":"8.60E+05","4T1-27_R18+":"1.24E+06","CTL-1_R23+":"5.50E+05","CTL-5_R2+":"5.21E+05","CTL-9_R1+":"5.61E+05","CTL-3_R6+":"6.96E+05","CTL-7_R3+":"6.90E+05","CTL-11_R21+":"5.81E+05","4T1-17_R4+":"1.38E+06","4T1-21_R22+":"2.66E+06","4T1-25_R16+":"2.95E+06","CTL-4_R20+":"1.78E+06","CTL-8_R13+":"2.87E+06","CTL-12_R14+":"2.76E+06"},{"Metabolite":"Spermine","4T1-1_R7+":"1.26E+05","4T1-15_R11+":"9.78E+04","4T1-19_R15+":"2.31E+04","4T1-27_R18+":"2.84E+04","CTL-1_R23+":"2.41E+04","CTL-5_R2+":"3.07E+04","CTL-9_R1+":"2.37E+04","CTL-3_R6+":"3.05E+04","CTL-7_R3+":"3.74E+04","CTL-11_R21+":"3.70E+04","4T1-17_R4+":"6.49E+04","4T1-21_R22+":"7.67E+04","4T1-25_R16+":"9.02E+04","CTL-4_R20+":"8.30E+04","CTL-8_R13+":"1.19E+05","CTL-12_R14+":"1.02E+05"},{"Metabolite":"N1-Acetylspermidine","4T1-1_R7+":"1.27E+05","4T1-15_R11+":"1.06E+05","4T1-19_R15+":"1.72E+05","4T1-27_R18+":"1.95E+05","CTL-1_R23+":"1.62E+04","CTL-5_R2+":"1.59E+04","CTL-9_R1+":"1.79E+04","CTL-3_R6+":"3.63E+04","CTL-7_R3+":"4.23E+04","CTL-11_R21+":"1.76E+04","4T1-17_R4+":"3.19E+05","4T1-21_R22+":"6.83E+05","4T1-25_R16+":"3.19E+05","CTL-4_R20+":"1.74E+05","CTL-8_R13+":"1.97E+05","CTL-12_R14+":"1.38E+05"},{"Metabolite":"Atherospermidine","4T1-1_R7+":"4.02E+03","4T1-15_R11+":"6.84E+03","4T1-19_R15+":"0.00E+00","4T1-27_R18+":"0.00E+00","CTL-1_R23+":"0.00E+00","CTL-5_R2+":"0.00E+00","CTL-9_R1+":"0.00E+00","CTL-3_R6+":"0.00E+00","CTL-7_R3+":"0.00E+00","CTL-11_R21+":"0.00E+00","4T1-17_R4+":"2.39E+04","4T1-21_R22+":"1.82E+04","4T1-25_R16+":"1.92E+04","CTL-4_R20+":"3.32E+04","CTL-8_R13+":"7.72E+03","CTL-12_R14+":"2.58E+04"},{"Metabolite":"Asymmetric dimethyl arginine","4T1-1_R7+":"3.19E+05","4T1-15_R11+":"1.86E+05","4T1-19_R15+":"3.25E+05","4T1-27_R18+":"2.81E+05","CTL-1_R23+":"2.17E+05","CTL-5_R2+":"2.61E+05","CTL-9_R1+":"3.07E+05","CTL-3_R6+":"3.19E+05","CTL-7_R3+":"2.19E+05","CTL-11_R21+":"2.29E+05","4T1-17_R4+":"1.31E+05","4T1-21_R22+":"3.45E+05","4T1-25_R16+":"2.46E+05","CTL-4_R20+":"1.35E+05","CTL-8_R13+":"1.56E+05","CTL-12_R14+":"1.43E+05"},{"Metabolite":"Carnosine","4T1-1_R7+":"1.72E+07","4T1-15_R11+":"1.74E+07","4T1-19_R15+":"3.65E+06","4T1-27_R18+":"7.53E+06","CTL-1_R23+":"1.94E+07","CTL-5_R2+":"1.61E+07","CTL-9_R1+":"1.60E+07","CTL-3_R6+":"1.64E+07","CTL-7_R3+":"1.47E+07","CTL-11_R21+":"1.63E+07","4T1-17_R4+":"7.89E+04","4T1-21_R22+":"8.74E+04","4T1-25_R16+":"1.49E+05","CTL-4_R20+":"6.55E+04","CTL-8_R13+":"8.42E+04","CTL-12_R14+":"4.78E+04"},{"Metabolite":"Phosphocreatine","4T1-1_R7+":"4.05E+05","4T1-15_R11+":"2.80E+06","4T1-19_R15+":"2.84E+04","4T1-27_R18+":"2.59E+04","CTL-1_R23+":"2.59E+04","CTL-5_R2+":"6.98E+04","CTL-9_R1+":"1.99E+04","CTL-3_R6+":"7.85E+05","CTL-7_R3+":"5.84E+05","CTL-11_R21+":"1.82E+04","4T1-17_R4+":"6.00E+05","4T1-21_R22+":"2.75E+05","4T1-25_R16+":"4.25E+05","CTL-4_R20+":"3.01E+05","CTL-8_R13+":"2.58E+05","CTL-12_R14+":"2.47E+05"},{"Metabolite":"Guanidinoacetate","4T1-1_R7+":"6.87E+05","4T1-15_R11+":"6.29E+05","4T1-19_R15+":"5.40E+05","4T1-27_R18+":"8.06E+05","CTL-1_R23+":"5.83E+05","CTL-5_R2+":"7.50E+05","CTL-9_R1+":"5.92E+05","CTL-3_R6+":"4.76E+05","CTL-7_R3+":"2.66E+05","CTL-11_R21+":"4.12E+05","4T1-17_R4+":"5.19E+05","4T1-21_R22+":"6.49E+05","4T1-25_R16+":"4.17E+05","CTL-4_R20+":"3.03E+05","CTL-8_R13+":"3.15E+05","CTL-12_R14+":"2.22E+05"},{"Metabolite":"trans-4-Hydroxy-L-proline","4T1-1_R7+":"4.40E+06","4T1-15_R11+":"3.50E+06","4T1-19_R15+":"1.92E+06","4T1-27_R18+":"2.90E+06","CTL-1_R23+":"8.71E+06","CTL-5_R2+":"7.71E+06","CTL-9_R1+":"6.86E+06","CTL-3_R6+":"8.80E+06","CTL-7_R3+":"6.42E+06","CTL-11_R21+":"7.18E+06","4T1-17_R4+":"1.13E+06","4T1-21_R22+":"1.86E+06","4T1-25_R16+":"1.35E+06","CTL-4_R20+":"9.39E+05","CTL-8_R13+":"8.81E+05","CTL-12_R14+":"7.22E+05"},{"Metabolite":"5-6-Dihydrouracil","4T1-1_R7+":"5.94E+05","4T1-15_R11+":"5.90E+05","4T1-19_R15+":"4.97E+05","4T1-27_R18+":"7.84E+05","CTL-1_R23+":"8.06E+05","CTL-5_R2+":"9.13E+05","CTL-9_R1+":"6.79E+05","CTL-3_R6+":"8.03E+05","CTL-7_R3+":"8.21E+05","CTL-11_R21+":"7.75E+05","4T1-17_R4+":"5.24E+04","4T1-21_R22+":"4.68E+04","4T1-25_R16+":"3.47E+04","CTL-4_R20+":"2.72E+04","CTL-8_R13+":"5.53E+04","CTL-12_R14+":"3.26E+04"},{"Metabolite":"Taurine","4T1-1_R7+":"1.72E+08","4T1-15_R11+":"1.84E+08","4T1-19_R15+":"1.54E+08","4T1-27_R18+":"1.76E+08","CTL-1_R23+":"1.71E+08","CTL-5_R2+":"1.88E+08","CTL-9_R1+":"1.59E+08","CTL-3_R6+":"1.89E+08","CTL-7_R3+":"1.70E+08","CTL-11_R21+":"1.85E+08","4T1-17_R4+":"5.40E+07","4T1-21_R22+":"5.13E+07","4T1-25_R16+":"5.52E+07","CTL-4_R20+":"4.93E+07","CTL-8_R13+":"4.24E+07","CTL-12_R14+":"3.80E+07"},{"Metabolite":"Hypotaurine","4T1-1_R7+":"1.01E+06","4T1-15_R11+":"1.53E+06","4T1-19_R15+":"1.48E+06","4T1-27_R18+":"2.04E+06","CTL-1_R23+":"1.64E+06","CTL-5_R2+":"1.76E+06","CTL-9_R1+":"1.41E+06","CTL-3_R6+":"1.97E+06","CTL-7_R3+":"1.57E+06","CTL-11_R21+":"1.51E+06","4T1-17_R4+":"1.06E+06","4T1-21_R22+":"8.44E+05","4T1-25_R16+":"6.58E+05","CTL-4_R20+":"7.24E+05","CTL-8_R13+":"7.71E+05","CTL-12_R14+":"6.60E+05"},{"Metabolite":"L-Methionine S-oxide","4T1-1_R7+":"2.26E+05","4T1-15_R11+":"1.37E+05","4T1-19_R15+":"2.10E+05","4T1-27_R18+":"1.42E+05","CTL-1_R23+":"1.34E+05","CTL-5_R2+":"1.78E+05","CTL-9_R1+":"3.01E+05","CTL-3_R6+":"1.27E+05","CTL-7_R3+":"1.62E+05","CTL-11_R21+":"1.62E+05","4T1-17_R4+":"3.07E+05","4T1-21_R22+":"3.29E+05","4T1-25_R16+":"1.62E+05","CTL-4_R20+":"2.61E+05","CTL-8_R13+":"4.06E+05","CTL-12_R14+":"3.83E+05"},{"Metabolite":"Kynurenine","4T1-1_R7+":"2.38E+04","4T1-15_R11+":"1.92E+04","4T1-19_R15+":"5.98E+04","4T1-27_R18+":"1.86E+04","CTL-1_R23+":"1.41E+04","CTL-5_R2+":"1.18E+04","CTL-9_R1+":"1.87E+04","CTL-3_R6+":"1.03E+04","CTL-7_R3+":"1.17E+04","CTL-11_R21+":"9.96E+03","4T1-17_R4+":"3.13E+04","4T1-21_R22+":"2.66E+04","4T1-25_R16+":"2.54E+04","CTL-4_R20+":"2.55E+04","CTL-8_R13+":"3.53E+04","CTL-12_R14+":"2.41E+04"},{"Metabolite":"N-formyl kynurenine","4T1-1_R7+":"1.15E+04","4T1-15_R11+":"1.72E+04","4T1-19_R15+":"5.92E+03","4T1-27_R18+":"1.24E+04","CTL-1_R23+":"1.57E+04","CTL-5_R2+":"1.44E+04","CTL-9_R1+":"2.65E+04","CTL-3_R6+":"5.48E+03","CTL-7_R3+":"1.27E+04","CTL-11_R21+":"7.83E+03","4T1-17_R4+":"9.26E+03","4T1-21_R22+":"1.27E+04","4T1-25_R16+":"1.58E+04","CTL-4_R20+":"1.10E+04","CTL-8_R13+":"1.22E+04","CTL-12_R14+":"3.18E+03"},{"Metabolite":"g-Oxalo-crotonate","4T1-1_R7+":"4.87E+05","4T1-15_R11+":"4.76E+05","4T1-19_R15+":"1.02E+06","4T1-27_R18+":"8.15E+05","CTL-1_R23+":"2.76E+05","CTL-5_R2+":"2.85E+05","CTL-9_R1+":"2.51E+05","CTL-3_R6+":"2.20E+05","CTL-7_R3+":"1.95E+05","CTL-11_R21+":"1.88E+05","4T1-17_R4+":"7.11E+05","4T1-21_R22+":"1.12E+06","4T1-25_R16+":"1.17E+06","CTL-4_R20+":"7.03E+05","CTL-8_R13+":"1.17E+06","CTL-12_R14+":"1.21E+06"},{"Metabolite":"2-Aminomuconate","4T1-1_R7+":"2.94E+04","4T1-15_R11+":"2.27E+04","4T1-19_R15+":"2.82E+04","4T1-27_R18+":"2.69E+04","CTL-1_R23+":"1.34E+04","CTL-5_R2+":"1.46E+04","CTL-9_R1+":"9.24E+03","CTL-3_R6+":"4.91E+04","CTL-7_R3+":"3.40E+04","CTL-11_R21+":"2.01E+04","4T1-17_R4+":"4.35E+04","4T1-21_R22+":"3.65E+04","4T1-25_R16+":"2.33E+04","CTL-4_R20+":"3.35E+04","CTL-8_R13+":"1.22E+04","CTL-12_R14+":"1.86E+04"},{"Metabolite":"L-Adrenaline","4T1-1_R7+":"6.99E+03","4T1-15_R11+":"6.00E+03","4T1-19_R15+":"1.67E+04","4T1-27_R18+":"1.68E+04","CTL-1_R23+":"4.66E+03","CTL-5_R2+":"9.90E+03","CTL-9_R1+":"1.70E+04","CTL-3_R6+":"1.61E+04","CTL-7_R3+":"1.68E+04","CTL-11_R21+":"2.63E+04","4T1-17_R4+":"8.94E+03","4T1-21_R22+":"9.26E+03","4T1-25_R16+":"6.39E+03","CTL-4_R20+":"7.95E+03","CTL-8_R13+":"4.99E+03","CTL-12_R14+":"8.61E+03"},{"Metabolite":"Serotonin","4T1-1_R7+":"2.96E+04","4T1-15_R11+":"2.39E+04","4T1-19_R15+":"4.37E+04","4T1-27_R18+":"1.67E+04","CTL-1_R23+":"1.81E+04","CTL-5_R2+":"2.11E+04","CTL-9_R1+":"2.18E+04","CTL-3_R6+":"1.31E+04","CTL-7_R3+":"1.02E+04","CTL-11_R21+":"9.45E+03","4T1-17_R4+":"1.01E+05","4T1-21_R22+":"2.82E+04","4T1-25_R16+":"3.40E+04","CTL-4_R20+":"6.31E+05","CTL-8_R13+":"5.01E+05","CTL-12_R14+":"5.70E+05"},{"Metabolite":"Ectoine","4T1-1_R7+":"1.60E+05","4T1-15_R11+":"1.82E+05","4T1-19_R15+":"1.47E+05","4T1-27_R18+":"7.39E+04","CTL-1_R23+":"1.28E+05","CTL-5_R2+":"1.49E+05","CTL-9_R1+":"2.09E+05","CTL-3_R6+":"3.09E+05","CTL-7_R3+":"2.09E+05","CTL-11_R21+":"2.27E+05","4T1-17_R4+":"1.61E+05","4T1-21_R22+":"1.17E+05","4T1-25_R16+":"2.36E+05","CTL-4_R20+":"3.21E+05","CTL-8_R13+":"4.80E+05","CTL-12_R14+":"4.57E+05"},{"Metabolite":"3D-(3-5/4)-Trihydroxycyclohexane-1-2-dione","4T1-1_R7+":"4.13E+03","4T1-15_R11+":"4.03E+03","4T1-19_R15+":"2.69E+03","4T1-27_R18+":"0.00E+00","CTL-1_R23+":"3.05E+03","CTL-5_R2+":"2.52E+03","CTL-9_R1+":"0.00E+00","CTL-3_R6+":"0.00E+00","CTL-7_R3+":"0.00E+00","CTL-11_R21+":"1.67E+03","4T1-17_R4+":"3.05E+04","4T1-21_R22+":"1.73E+04","4T1-25_R16+":"4.87E+04","CTL-4_R20+":"6.35E+04","CTL-8_R13+":"6.20E+04","CTL-12_R14+":"7.28E+04"},{"Metabolite":"sn-glycero-3-Phosphoethanolamine","4T1-1_R7+":"2.77E+05","4T1-15_R11+":"1.93E+05","4T1-19_R15+":"2.41E+05","4T1-27_R18+":"5.16E+05","CTL-1_R23+":"1.21E+05","CTL-5_R2+":"9.54E+04","CTL-9_R1+":"1.06E+05","CTL-3_R6+":"1.11E+05","CTL-7_R3+":"1.16E+05","CTL-11_R21+":"7.76E+04","4T1-17_R4+":"1.30E+06","4T1-21_R22+":"1.11E+06","4T1-25_R16+":"8.16E+05","CTL-4_R20+":"1.06E+06","CTL-8_R13+":"9.80E+05","CTL-12_R14+":"8.13E+05"},{"Metabolite":"Diethanolamine","4T1-1_R7+":"2.76E+04","4T1-15_R11+":"4.73E+04","4T1-19_R15+":"1.60E+04","4T1-27_R18+":"4.17E+04","CTL-1_R23+":"9.29E+03","CTL-5_R2+":"2.21E+04","CTL-9_R1+":"1.62E+04","CTL-3_R6+":"1.83E+04","CTL-7_R3+":"1.77E+04","CTL-11_R21+":"1.74E+04","4T1-17_R4+":"1.35E+04","4T1-21_R22+":"1.33E+04","4T1-25_R16+":"1.81E+04","CTL-4_R20+":"1.35E+04","CTL-8_R13+":"1.98E+04","CTL-12_R14+":"1.09E+04"},{"Metabolite":"Triethanolamine","4T1-1_R7+":"3.45E+05","4T1-15_R11+":"2.15E+05","4T1-19_R15+":"1.58E+06","4T1-27_R18+":"2.76E+05","CTL-1_R23+":"5.46E+04","CTL-5_R2+":"2.85E+04","CTL-9_R1+":"2.35E+04","CTL-3_R6+":"3.57E+04","CTL-7_R3+":"1.38E+04","CTL-11_R21+":"1.28E+04","4T1-17_R4+":"1.51E+04","4T1-21_R22+":"7.17E+04","4T1-25_R16+":"4.00E+04","CTL-4_R20+":"8.78E+03","CTL-8_R13+":"1.27E+04","CTL-12_R14+":"1.85E+04"},{"Metabolite":"N-Methylethanolamine phosphate","4T1-1_R7+":"1.31E+05","4T1-15_R11+":"1.41E+05","4T1-19_R15+":"1.44E+05","4T1-27_R18+":"1.66E+05","CTL-1_R23+":"1.72E+05","CTL-5_R2+":"1.64E+05","CTL-9_R1+":"1.75E+05","CTL-3_R6+":"1.71E+05","CTL-7_R3+":"1.75E+05","CTL-11_R21+":"1.79E+05","4T1-17_R4+":"1.48E+05","4T1-21_R22+":"1.24E+05","4T1-25_R16+":"1.36E+05","CTL-4_R20+":"1.12E+05","CTL-8_R13+":"1.17E+05","CTL-12_R14+":"1.13E+05"},{"Metabolite":"CDP-choline","4T1-1_R7+":"2.72E+04","4T1-15_R11+":"3.68E+04","4T1-19_R15+":"6.62E+04","4T1-27_R18+":"7.80E+04","CTL-1_R23+":"1.69E+04","CTL-5_R2+":"7.59E+03","CTL-9_R1+":"1.36E+04","CTL-3_R6+":"3.32E+04","CTL-7_R3+":"1.13E+04","CTL-11_R21+":"1.29E+04","4T1-17_R4+":"3.13E+04","4T1-21_R22+":"1.77E+05","4T1-25_R16+":"5.63E+04","CTL-4_R20+":"3.37E+04","CTL-8_R13+":"2.38E+04","CTL-12_R14+":"4.14E+04"},{"Metabolite":"L-Carnitine","4T1-1_R7+":"9.60E+07","4T1-15_R11+":"1.11E+08","4T1-19_R15+":"7.93E+07","4T1-27_R18+":"9.70E+07","CTL-1_R23+":"1.68E+08","CTL-5_R2+":"1.64E+08","CTL-9_R1+":"1.49E+08","CTL-3_R6+":"1.10E+08","CTL-7_R3+":"9.91E+07","CTL-11_R21+":"1.10E+08","4T1-17_R4+":"7.01E+07","4T1-21_R22+":"4.38E+07","4T1-25_R16+":"4.38E+07","CTL-4_R20+":"6.48E+07","CTL-8_R13+":"6.27E+07","CTL-12_R14+":"4.72E+07"},{"Metabolite":"Acetylcarnitine","4T1-1_R7+":"2.00E+08","4T1-15_R11+":"9.90E+07","4T1-19_R15+":"1.20E+08","4T1-27_R18+":"9.89E+07","CTL-1_R23+":"1.42E+08","CTL-5_R2+":"1.79E+08","CTL-9_R1+":"1.38E+08","CTL-3_R6+":"1.22E+08","CTL-7_R3+":"1.01E+08","CTL-11_R21+":"9.81E+07","4T1-17_R4+":"7.81E+07","4T1-21_R22+":"5.54E+07","4T1-25_R16+":"3.84E+07","CTL-4_R20+":"5.76E+07","CTL-8_R13+":"4.51E+07","CTL-12_R14+":"5.81E+07"},{"Metabolite":"Propenoylcarnitine","4T1-1_R7+":"2.81E+04","4T1-15_R11+":"1.16E+04","4T1-19_R15+":"1.13E+04","4T1-27_R18+":"5.20E+03","CTL-1_R23+":"1.98E+04","CTL-5_R2+":"2.02E+04","CTL-9_R1+":"1.86E+04","CTL-3_R6+":"2.67E+04","CTL-7_R3+":"2.30E+04","CTL-11_R21+":"1.08E+04","4T1-17_R4+":"1.33E+04","4T1-21_R22+":"1.05E+04","4T1-25_R16+":"1.47E+04","CTL-4_R20+":"1.04E+04","CTL-8_R13+":"1.47E+04","CTL-12_R14+":"1.14E+04"},{"Metabolite":"Propionylcarnitine","4T1-1_R7+":"7.34E+05","4T1-15_R11+":"7.51E+05","4T1-19_R15+":"4.80E+05","4T1-27_R18+":"5.48E+05","CTL-1_R23+":"2.65E+05","CTL-5_R2+":"4.18E+05","CTL-9_R1+":"3.76E+05","CTL-3_R6+":"3.59E+05","CTL-7_R3+":"3.60E+05","CTL-11_R21+":"4.39E+05","4T1-17_R4+":"4.57E+05","4T1-21_R22+":"2.68E+05","4T1-25_R16+":"2.25E+05","CTL-4_R20+":"2.57E+05","CTL-8_R13+":"2.12E+05","CTL-12_R14+":"2.07E+05"},{"Metabolite":"Butyrylcarnitine","4T1-1_R7+":"5.46E+06","4T1-15_R11+":"6.36E+06","4T1-19_R15+":"5.18E+06","4T1-27_R18+":"5.42E+06","CTL-1_R23+":"3.81E+06","CTL-5_R2+":"4.47E+06","CTL-9_R1+":"7.49E+06","CTL-3_R6+":"5.23E+06","CTL-7_R3+":"5.82E+06","CTL-11_R21+":"4.82E+06","4T1-17_R4+":"1.01E+07","4T1-21_R22+":"3.90E+06","4T1-25_R16+":"2.77E+06","CTL-4_R20+":"5.14E+06","CTL-8_R13+":"4.34E+06","CTL-12_R14+":"3.80E+06"},{"Metabolite":"Tiglylcarnitine","4T1-1_R7+":"6.56E+04","4T1-15_R11+":"1.61E+05","4T1-19_R15+":"6.18E+04","4T1-27_R18+":"1.24E+05","CTL-1_R23+":"5.26E+04","CTL-5_R2+":"1.68E+05","CTL-9_R1+":"1.89E+05","CTL-3_R6+":"5.51E+04","CTL-7_R3+":"1.58E+05","CTL-11_R21+":"1.65E+05","4T1-17_R4+":"3.96E+04","4T1-21_R22+":"2.50E+04","4T1-25_R16+":"3.12E+04","CTL-4_R20+":"1.81E+04","CTL-8_R13+":"2.99E+04","CTL-12_R14+":"1.44E+04"},{"Metabolite":"Isovalerylcarnitine","4T1-1_R7+":"9.43E+05","4T1-15_R11+":"1.21E+06","4T1-19_R15+":"7.22E+05","4T1-27_R18+":"1.17E+06","CTL-1_R23+":"3.63E+05","CTL-5_R2+":"8.26E+05","CTL-9_R1+":"1.24E+06","CTL-3_R6+":"2.75E+05","CTL-7_R3+":"7.46E+05","CTL-11_R21+":"1.09E+06","4T1-17_R4+":"1.11E+06","4T1-21_R22+":"6.42E+05","4T1-25_R16+":"6.66E+05","CTL-4_R20+":"4.36E+05","CTL-8_R13+":"9.79E+05","CTL-12_R14+":"6.39E+05"},{"Metabolite":"Malonylcarnitine","4T1-1_R7+":"5.82E+05","4T1-15_R11+":"4.42E+05","4T1-19_R15+":"4.74E+05","4T1-27_R18+":"4.17E+05","CTL-1_R23+":"6.46E+05","CTL-5_R2+":"7.81E+05","CTL-9_R1+":"6.93E+05","CTL-3_R6+":"3.60E+05","CTL-7_R3+":"3.60E+05","CTL-11_R21+":"4.04E+05","4T1-17_R4+":"1.33E+05","4T1-21_R22+":"8.44E+04","4T1-25_R16+":"1.38E+05","CTL-4_R20+":"7.71E+04","CTL-8_R13+":"8.70E+04","CTL-12_R14+":"7.87E+04"},{"Metabolite":"Hexenoylcarnitine","4T1-1_R7+":"3.57E+04","4T1-15_R11+":"4.14E+04","4T1-19_R15+":"2.00E+04","4T1-27_R18+":"5.84E+04","CTL-1_R23+":"4.43E+04","CTL-5_R2+":"5.41E+04","CTL-9_R1+":"5.39E+04","CTL-3_R6+":"4.05E+04","CTL-7_R3+":"6.15E+04","CTL-11_R21+":"3.26E+04","4T1-17_R4+":"3.92E+04","4T1-21_R22+":"3.97E+04","4T1-25_R16+":"4.33E+04","CTL-4_R20+":"2.96E+04","CTL-8_R13+":"4.52E+04","CTL-12_R14+":"4.47E+04"},{"Metabolite":"Hexanoylcarnitine","4T1-1_R7+":"1.30E+06","4T1-15_R11+":"1.11E+06","4T1-19_R15+":"1.46E+06","4T1-27_R18+":"1.83E+06","CTL-1_R23+":"1.16E+06","CTL-5_R2+":"9.71E+05","CTL-9_R1+":"1.91E+06","CTL-3_R6+":"1.20E+06","CTL-7_R3+":"1.42E+06","CTL-11_R21+":"1.52E+06","4T1-17_R4+":"7.81E+05","4T1-21_R22+":"3.25E+05","4T1-25_R16+":"2.40E+05","CTL-4_R20+":"3.51E+05","CTL-8_R13+":"3.02E+05","CTL-12_R14+":"2.84E+05"},{"Metabolite":"Methylmalonylcarnitine","4T1-1_R7+":"7.12E+05","4T1-15_R11+":"3.05E+05","4T1-19_R15+":"5.40E+05","4T1-27_R18+":"6.08E+05","CTL-1_R23+":"6.71E+05","CTL-5_R2+":"1.03E+06","CTL-9_R1+":"1.04E+06","CTL-3_R6+":"8.25E+05","CTL-7_R3+":"9.57E+05","CTL-11_R21+":"6.06E+05","4T1-17_R4+":"1.06E+05","4T1-21_R22+":"9.63E+04","4T1-25_R16+":"1.83E+05","CTL-4_R20+":"8.59E+04","CTL-8_R13+":"1.06E+05","CTL-12_R14+":"8.21E+04"},{"Metabolite":"Hydroxyisovaleroyl carnitine","4T1-1_R7+":"2.70E+05","4T1-15_R11+":"1.97E+05","4T1-19_R15+":"1.24E+05","4T1-27_R18+":"1.41E+05","CTL-1_R23+":"2.34E+05","CTL-5_R2+":"2.41E+05","CTL-9_R1+":"2.63E+05","CTL-3_R6+":"2.37E+05","CTL-7_R3+":"2.49E+05","CTL-11_R21+":"1.71E+05","4T1-17_R4+":"9.88E+04","4T1-21_R22+":"6.35E+04","4T1-25_R16+":"7.20E+04","CTL-4_R20+":"7.27E+04","CTL-8_R13+":"9.85E+04","CTL-12_R14+":"5.72E+04"},{"Metabolite":"Octenoylcarnitine","4T1-1_R7+":"4.54E+04","4T1-15_R11+":"3.28E+04","4T1-19_R15+":"3.52E+04","4T1-27_R18+":"5.19E+04","CTL-1_R23+":"5.89E+04","CTL-5_R2+":"3.04E+04","CTL-9_R1+":"6.13E+04","CTL-3_R6+":"3.51E+04","CTL-7_R3+":"3.10E+04","CTL-11_R21+":"4.39E+04","4T1-17_R4+":"2.30E+04","4T1-21_R22+":"1.70E+04","4T1-25_R16+":"1.87E+04","CTL-4_R20+":"1.56E+04","CTL-8_R13+":"1.44E+04","CTL-12_R14+":"1.80E+04"},{"Metabolite":"Octanoylcarnitine","4T1-1_R7+":"4.79E+05","4T1-15_R11+":"4.51E+05","4T1-19_R15+":"5.45E+05","4T1-27_R18+":"2.22E+05","CTL-1_R23+":"4.03E+05","CTL-5_R2+":"2.89E+05","CTL-9_R1+":"7.26E+05","CTL-3_R6+":"3.52E+05","CTL-7_R3+":"3.46E+05","CTL-11_R21+":"5.61E+05","4T1-17_R4+":"1.34E+05","4T1-21_R22+":"3.19E+04","4T1-25_R16+":"3.75E+04","CTL-4_R20+":"5.29E+04","CTL-8_R13+":"4.24E+04","CTL-12_R14+":"3.62E+04"},{"Metabolite":"Methylglutarylcarnitine","4T1-1_R7+":"1.55E+04","4T1-15_R11+":"1.75E+04","4T1-19_R15+":"2.15E+04","4T1-27_R18+":"1.74E+04","CTL-1_R23+":"1.87E+04","CTL-5_R2+":"1.70E+04","CTL-9_R1+":"1.63E+04","CTL-3_R6+":"2.22E+04","CTL-7_R3+":"1.30E+04","CTL-11_R21+":"6.25E+03","4T1-17_R4+":"1.40E+04","4T1-21_R22+":"2.11E+04","4T1-25_R16+":"8.97E+03","CTL-4_R20+":"2.16E+04","CTL-8_R13+":"1.17E+04","CTL-12_R14+":"2.08E+04"},{"Metabolite":"Pimelylcarnitine","4T1-1_R7+":"1.26E+04","4T1-15_R11+":"2.10E+04","4T1-19_R15+":"5.46E+03","4T1-27_R18+":"1.72E+04","CTL-1_R23+":"2.02E+04","CTL-5_R2+":"1.63E+04","CTL-9_R1+":"6.04E+03","CTL-3_R6+":"1.09E+04","CTL-7_R3+":"1.82E+04","CTL-11_R21+":"7.52E+03","4T1-17_R4+":"1.00E+04","4T1-21_R22+":"6.95E+03","4T1-25_R16+":"2.87E+04","CTL-4_R20+":"9.44E+03","CTL-8_R13+":"2.55E+04","CTL-12_R14+":"1.97E+04"},{"Metabolite":"Hydroxyoctanoyl carnitine","4T1-1_R7+":"1.53E+05","4T1-15_R11+":"1.14E+05","4T1-19_R15+":"1.56E+05","4T1-27_R18+":"2.54E+05","CTL-1_R23+":"2.93E+05","CTL-5_R2+":"1.76E+05","CTL-9_R1+":"3.45E+05","CTL-3_R6+":"1.87E+05","CTL-7_R3+":"1.95E+05","CTL-11_R21+":"2.30E+05","4T1-17_R4+":"1.70E+05","4T1-21_R22+":"1.15E+05","4T1-25_R16+":"5.75E+04","CTL-4_R20+":"1.02E+05","CTL-8_R13+":"8.58E+04","CTL-12_R14+":"9.51E+04"},{"Metabolite":"Decanoylcarnitine","4T1-1_R7+":"7.07E+04","4T1-15_R11+":"2.22E+04","4T1-19_R15+":"6.39E+04","4T1-27_R18+":"5.87E+04","CTL-1_R23+":"6.86E+04","CTL-5_R2+":"3.21E+04","CTL-9_R1+":"1.02E+05","CTL-3_R6+":"6.98E+04","CTL-7_R3+":"4.40E+04","CTL-11_R21+":"7.70E+04","4T1-17_R4+":"1.35E+04","4T1-21_R22+":"5.52E+03","4T1-25_R16+":"1.06E+04","CTL-4_R20+":"1.12E+04","CTL-8_R13+":"5.24E+03","CTL-12_R14+":"4.30E+03"},{"Metabolite":"Hydroxynonanoyl 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CTL-12_R14+":"9.14E+05"}],

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}

}