{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002153","ANALYSIS_ID":"AN003526","VERSION":"1","CREATED_ON":"April 19, 2022, 12:02 am"},

"PROJECT":{"PROJECT_TITLE":"Improvement of cognitive function by B. breve MCC1274 and elucidation of its mechanism of action","PROJECT_SUMMARY":"Although many studies have suggested that probiotics could modulate various brain functions via the gut-brain axis, little is known about the mechanism underlying this process. We previously reported the beneficial effects of a probiotic strain, Bifidobacterium breve MCC1274, on cognitive function in preclinical and clinical studies. Recently, we showed that administration of this strain reduced amyloid-beta production, inhibited microglial activation, and suppressed inflammatory responses in the brains of APP knock-in (AppNL-G-F) mice. To elucidate the mechanism of action of this probiotic strain in an Alzheimer's disease-like model, we orally fed 3-month-old mice with B. breve MCC1274 or saline for 4 months and comprehensively investigated metabolites in plasma using CE-FTMS and LC-TOFMS.","INSTITUTE":"Morinaga milk industry CO., LTD.","DEPARTMENT":"Next generation science institute","LABORATORY":"Frontier research section","LAST_NAME":"Ohno","FIRST_NAME":"Kazuya","ADDRESS":"1-83 5-Chome Higashihara, Zama-city, Kanagawa-Pref. Japan","EMAIL":"kazuya-oono443@morinagamilk.co.jp","PHONE":"81462523067"},

"STUDY":{"STUDY_TITLE":"Data from plasma metabolome analysis of APP-KI and Wild type mice treated with B. breve MCC1274","STUDY_SUMMARY":"Recently, we showed that administration of B. breve MCC1274 reduced amyloid-beta production, inhibited microglial activation, and suppressed inflammatory responses in the brains of APP knock-in (AppNL-G-F) mice. To elucidate the mechanism of action of this probiotic strain in an Alzheimer's disease-like model, we orally fed 3-month-old mice with B. breve MCC1274 or saline for 4 months and comprehensively investigated metabolites in plasma using CE-FTMS and LC-TOFMS.","INSTITUTE":"Morinaga milk industry CO., LTD.","DEPARTMENT":"Next generation science institute","LABORATORY":"Frontier research section","LAST_NAME":"Ohno","FIRST_NAME":"Kazuya","ADDRESS":"1-83 5-Chome Higashihara, Zama-city, Kanagawa-Pref. Japan","EMAIL":"kazuya-oono443@morinagamilk.co.jp","PHONE":"81462523067"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090","GENOTYPE_STRAIN":"AppNL-G-F or wild type mice","AGE_OR_AGE_RANGE":"7 months old","GENDER":"Male and female","ANIMAL_ANIMAL_SUPPLIER":"RIKEN Center for Brain Science","ANIMAL_LIGHT_CYCLE":"12 hours light and dark cycle"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"WC-1",
"Factors":{"Model":"Wild type","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"WC-2",
"Factors":{"Model":"Wild type","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"WC-3",
"Factors":{"Model":"Wild type","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"WC-4",
"Factors":{"Model":"Wild type","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"WT-1",
"Factors":{"Model":"Wild type","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"WT-2",
"Factors":{"Model":"Wild type","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"WT-3",
"Factors":{"Model":"Wild type","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"WT-4",
"Factors":{"Model":"Wild type","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"AC-1",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"AC-2",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"AC-3",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"AC-4",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"AT-1",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"AT-2",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"AT-3",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"AT-4",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"B. breve MCC1274"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Plasma samples were obtained from AD-like model and wild-type mice orally administered B. breve MCC1274 or saline for 4 months.","SAMPLE_TYPE":"Blood (plasma)","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"Three-month-old AppNL-G-F and wild type mice were randomly assigned to a vehicle group and a probiotic group. The vehicle group received saline, and the probiotic group received B. breve MCC1274 (1 × 10＾9 cfu/200 μl saline/mouse) orally 5 times a week for 4 months.","TREATMENT_COMPOUND":"Bifidobacterium breve MCC1274","TREATMENT_ROUTE":"oral administration","TREATMENT_DOSEVOLUME":"1 × 10＾9 cfu/200 μl saline","TREATMENT_VEHICLE":"saline"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"For CE-FTMS, 40 µL of plasma was added to 160 µL of methanol containing internal standards at 0°C, 120 µL of Milli-Q water was added and mixed thoroughly, and 240 µL of this mixture was added to a Millipore 5 kDa cutoff filter (ULTRAFREE MC PLHCC, HMT) at 9100 × g for 120 min at 4°C to remove macromolecules. The filtrate was evaporated to dryness under vacuum, dissolved in 40 µL Milli-Q water, and donated to HMT's ω Scan package using capillary electrophoresis Fourier transform mass spectrometry (CE-FTMS).For LC-TOFMS, 80 µL of plasma was added to 240 µL of 1% formic acid/acetonitrile containing internal standards at 0ºC. The mixture was centrifuged at 2,300 x g, 4ºC for 5 min, then centrifuged at 2,300 x g, 4ºC for 5 min, followed by centrifugation of a hybrid SPE phospholipid cartridge (30 mg/mL of hybrid SPE-phospholipid, 30 mg/mL of (SUPELCO) and filtered to remove phospholipids. The filtrate was then evaporated to dryness under nitrogen, dissolved in 80 μL of 50% isopropanol (v/v), and metabolomic analysis was performed using liquid chromatography time-of-flight mass spectrometry (LC-TOFMS)."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Normal phase","INSTRUMENT_NAME":"Agilent 1260","COLUMN_NAME":"fused silica capillary (50 μm i.d. × 80 cm total length; Polymicro Technologies, Inc., Phoenix, AZ)","SOLVENT_A":"commercial electrophoresis buffer (H3301-1001 and I3302-1023 for cation and anion analyses, respectively, HMT)","INTERNAL_STANDARD":"H3304-1002, Human Metabolome Technologies, Inc. (HMT), Tsuruoka, Yamagata, Japan"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Plus Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"UNSPECIFIED","MS_COMMENTS":"The spectrometer was scanned from m/z 60 to 900 in positive mode, and from m/z 70 to 1,050 in negative mode"},

"MS_METABOLITE_DATA":{
"Units":"peak area",

"Data":[{"Metabolite":"1-Methyl-4-imidazoleacetic acid","WC-1":"7.7E-04","WC-2":"5.4E-04","WC-3":"5.8E-04","WC-4":"8.0E-04","WT-1":"6.5E-04","WT-2":"5.3E-04","WT-3":"6.8E-04","WT-4":"9.9E-04","AC-1":"7.2E-04","AC-2":"6.5E-04","AC-3":"5.6E-04","AC-4":"1.0E-03","AT-1":"8.5E-04","AT-2":"7.8E-04","AT-3":"7.0E-04","AT-4":"5.2E-04"},{"Metabolite":"1-Methyladenosine","WC-1":"6.6E-04","WC-2":"4.7E-04","WC-3":"5.8E-04","WC-4":"5.6E-04","WT-1":"4.2E-04","WT-2":"3.2E-04","WT-3":"4.9E-04","WT-4":"5.1E-04","AC-1":"3.4E-04","AC-2":"3.2E-04","AC-3":"3.4E-04","AC-4":"5.8E-04","AT-1":"5.2E-04","AT-2":"5.9E-04","AT-3":"4.7E-04","AT-4":"3.9E-04"},{"Metabolite":"1-Methylhistamine","WC-1":"1.2E-04","WC-2":"1.1E-04","WC-3":"4.1E-05","WC-4":"7.0E-05","WT-1":"6.9E-05","WT-2":"6.8E-05","WT-3":"6.0E-05","WT-4":"2.7E-04","AC-1":"1.0E-04","AC-2":"1.4E-04","AC-3":"2.6E-04","AC-4":"1.0E-04","AT-1":"1.1E-04","AT-2":"9.2E-05","AT-3":"1.0E-04","AT-4":"6.6E-05"},{"Metabolite":"1-Methylhydantoin　Glycine anhydride","WC-1":"4.5E-03","WC-2":"2.9E-03","WC-3":"3.1E-03","WC-4":"3.6E-03","WT-1":"5.7E-03","WT-2":"3.8E-03","WT-3":"3.8E-03","WT-4":"6.3E-03","AC-1":"6.4E-03","AC-2":"4.7E-03","AC-3":"3.5E-03","AC-4":"4.5E-03","AT-1":"3.5E-03","AT-2":"5.2E-03","AT-3":"4.8E-03","AT-4":"4.5E-03"},{"Metabolite":"1-Methylnicotinamide","WC-1":"1.1E-03","WC-2":"8.3E-04","WC-3":"1.2E-03","WC-4":"1.2E-03","WT-1":"3.5E-04","WT-2":"2.7E-04","WT-3":"4.9E-04","WT-4":"1.8E-03","AC-1":"1.4E-03","AC-2":"6.6E-04","AC-3":"5.1E-04","AC-4":"1.8E-03","AT-1":"7.0E-04","AT-2":"8.1E-04","AT-3":"4.4E-04","AT-4":"3.1E-04"},{"Metabolite":"1-Methyluric acid","WC-1":"7.4E-05","WC-2":"5.8E-05","WC-3":"8.0E-05","WC-4":"7.9E-05","WT-1":"9.1E-05","WT-2":"N.D.","WT-3":"8.9E-05","WT-4":"9.2E-05","AC-1":"4.4E-05","AC-2":"N.D.","AC-3":"4.6E-05","AC-4":"8.7E-05","AT-1":"9.2E-05","AT-2":"1.1E-04","AT-3":"5.6E-05","AT-4":"5.5E-05"},{"Metabolite":"10-Hydroxydecanoic acid","WC-1":"6.1E-05","WC-2":"5.4E-05","WC-3":"1.3E-04","WC-4":"4.3E-05","WT-1":"1.1E-04","WT-2":"7.9E-05","WT-3":"1.1E-04","WT-4":"6.9E-05","AC-1":"2.1E-04","AC-2":"N.D.","AC-3":"4.0E-05","AC-4":"8.3E-05","AT-1":"5.2E-05","AT-2":"9.1E-05","AT-3":"8.1E-05","AT-4":"1.1E-04"},{"Metabolite":"11-Aminoundecanoic acid","WC-1":"1.9E-04","WC-2":"2.7E-04","WC-3":"1.7E-04","WC-4":"2.4E-04","WT-1":"2.4E-04","WT-2":"2.3E-04","WT-3":"2.5E-04","WT-4":"2.6E-04","AC-1":"2.1E-04","AC-2":"2.2E-04","AC-3":"2.2E-04","AC-4":"2.3E-04","AT-1":"2.9E-04","AT-2":"2.5E-04","AT-3":"2.4E-04","AT-4":"2.1E-04"},{"Metabolite":"1H-Imidazole-4-propionic acid","WC-1":"1.1E-04","WC-2":"5.7E-05","WC-3":"5.9E-05","WC-4":"2.3E-04","WT-1":"3.3E-04","WT-2":"1.3E-04","WT-3":"3.9E-04","WT-4":"5.8E-04","AC-1":"1.2E-04","AC-2":"3.2E-04","AC-3":"4.7E-05","AC-4":"1.0E-04","AT-1":"2.7E-04","AT-2":"5.3E-04","AT-3":"2.7E-04","AT-4":"2.0E-04"},{"Metabolite":"2'-Deoxyadenosine　5'-Deoxyadenosine","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"3.0E-05","WT-3":"N.D.","WT-4":"2.5E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"1.4E-05","AT-3":"N.D.","AT-4":"8.2E-06"},{"Metabolite":"2'-Deoxycytidine","WC-1":"1.6E-03","WC-2":"1.8E-03","WC-3":"1.9E-03","WC-4":"1.3E-03","WT-1":"1.5E-03","WT-2":"1.5E-03","WT-3":"1.2E-03","WT-4":"1.3E-03","AC-1":"1.5E-03","AC-2":"1.5E-03","AC-3":"1.7E-03","AC-4":"1.4E-03","AT-1":"1.4E-03","AT-2":"1.8E-03","AT-3":"1.6E-03","AT-4":"1.4E-03"},{"Metabolite":"2'-Deoxyuridine","WC-1":"2.3E-03","WC-2":"1.6E-03","WC-3":"N.D.","WC-4":"2.5E-03","WT-1":"1.4E-03","WT-2":"1.6E-03","WT-3":"1.4E-03","WT-4":"2.0E-03","AC-1":"9.9E-04","AC-2":"8.4E-04","AC-3":"9.0E-04","AC-4":"7.3E-04","AT-1":"4.2E-04","AT-2":"6.9E-04","AT-3":"7.5E-04","AT-4":"8.5E-04"},{"Metabolite":"2,3-Diphosphoglyceric acid","WC-1":"6.1E-03","WC-2":"3.1E-03","WC-3":"5.6E-03","WC-4":"9.1E-04","WT-1":"4.2E-03","WT-2":"6.1E-03","WT-3":"3.5E-03","WT-4":"5.3E-03","AC-1":"4.6E-03","AC-2":"2.4E-03","AC-3":"2.8E-03","AC-4":"3.2E-03","AT-1":"1.6E-03","AT-2":"6.0E-03","AT-3":"1.9E-03","AT-4":"1.6E-03"},{"Metabolite":"2,5-Dihydroxybenzoic acid","WC-1":"1.4E-04","WC-2":"N.D.","WC-3":"N.D.","WC-4":"1.3E-04","WT-1":"1.6E-04","WT-2":"9.9E-05","WT-3":"1.1E-04","WT-4":"1.9E-04","AC-1":"1.3E-04","AC-2":"1.5E-04","AC-3":"9.7E-05","AC-4":"8.1E-05","AT-1":"1.8E-04","AT-2":"1.4E-04","AT-3":"1.6E-04","AT-4":"1.3E-04"},{"Metabolite":"2,6-Diaminopimelic acid","WC-1":"9.3E-05","WC-2":"5.1E-05","WC-3":"7.7E-05","WC-4":"2.0E-04","WT-1":"2.1E-04","WT-2":"9.8E-05","WT-3":"1.1E-04","WT-4":"3.6E-04","AC-1":"1.9E-04","AC-2":"3.4E-04","AC-3":"3.9E-05","AC-4":"1.5E-04","AT-1":"2.9E-04","AT-2":"4.4E-04","AT-3":"1.6E-04","AT-4":"2.6E-04"},{"Metabolite":"2-(Creatinine-3-yl)propionic acid","WC-1":"1.5E-05","WC-2":"3.2E-05","WC-3":"N.D.","WC-4":"3.4E-05","WT-1":"9.2E-06","WT-2":"1.8E-05","WT-3":"N.D.","WT-4":"2.9E-05","AC-1":"1.9E-05","AC-2":"6.1E-05","AC-3":"5.1E-05","AC-4":"6.2E-05","AT-1":"4.0E-05","AT-2":"3.1E-05","AT-3":"2.7E-05","AT-4":"1.3E-05"},{"Metabolite":"2-Amino-2-(hydroxymethyl)-1,3-propanediol","WC-1":"3.8E-04","WC-2":"2.9E-04","WC-3":"3.8E-04","WC-4":"2.4E-04","WT-1":"2.9E-04","WT-2":"3.1E-04","WT-3":"4.3E-04","WT-4":"4.8E-04","AC-1":"2.4E-04","AC-2":"1.7E-04","AC-3":"2.0E-04","AC-4":"2.6E-04","AT-1":"1.9E-04","AT-2":"2.1E-04","AT-3":"2.1E-04","AT-4":"4.4E-04"},{"Metabolite":"2-Aminoadipic acid　O-Acetylhomoserine","WC-1":"8.7E-03","WC-2":"7.7E-03","WC-3":"8.0E-03","WC-4":"9.7E-03","WT-1":"1.0E-02","WT-2":"8.9E-03","WT-3":"1.0E-02","WT-4":"1.6E-02","AC-1":"8.3E-03","AC-2":"1.0E-02","AC-3":"8.7E-03","AC-4":"8.5E-03","AT-1":"1.2E-02","AT-2":"8.5E-03","AT-3":"9.3E-03","AT-4":"9.2E-03"},{"Metabolite":"2-Aminobutyric acid　2-Aminoisobutyric acid","WC-1":"1.3E-02","WC-2":"6.0E-03","WC-3":"6.3E-03","WC-4":"1.0E-02","WT-1":"1.1E-02","WT-2":"8.2E-03","WT-3":"1.0E-02","WT-4":"1.8E-02","AC-1":"1.1E-02","AC-2":"1.0E-02","AC-3":"7.2E-03","AC-4":"1.1E-02","AT-1":"1.2E-02","AT-2":"1.1E-02","AT-3":"9.6E-03","AT-4":"1.1E-02"},{"Metabolite":"2-Hydroxy-4-methylvaleric acid","WC-1":"5.0E-04","WC-2":"1.4E-03","WC-3":"1.3E-03","WC-4":"4.3E-04","WT-1":"7.6E-04","WT-2":"9.1E-04","WT-3":"1.3E-03","WT-4":"5.8E-04","AC-1":"4.5E-04","AC-2":"6.5E-04","AC-3":"1.2E-03","AC-4":"4.2E-04","AT-1":"9.3E-04","AT-2":"7.1E-04","AT-3":"1.2E-03","AT-4":"1.2E-03"},{"Metabolite":"2-Hydroxybutyric acid","WC-1":"1.2E-02","WC-2":"6.3E-03","WC-3":"8.3E-03","WC-4":"1.1E-02","WT-1":"1.7E-02","WT-2":"1.2E-02","WT-3":"2.1E-02","WT-4":"2.6E-02","AC-1":"1.2E-02","AC-2":"7.8E-03","AC-3":"5.6E-03","AC-4":"1.1E-02","AT-1":"1.5E-02","AT-2":"1.4E-02","AT-3":"1.3E-02","AT-4":"1.3E-02"},{"Metabolite":"2-Hydroxyoctanoic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"6.9E-05","WT-1":"5.6E-05","WT-2":"N.D.","WT-3":"N.D.","WT-4":"8.1E-05","AC-1":"6.7E-05","AC-2":"N.D.","AC-3":"N.D.","AC-4":"3.0E-05","AT-1":"1.9E-05","AT-2":"8.9E-05","AT-3":"5.6E-05","AT-4":"N.D."},{"Metabolite":"2-Hydroxyvaleric acid","WC-1":"2.4E-03","WC-2":"7.4E-03","WC-3":"8.1E-03","WC-4":"2.3E-03","WT-1":"5.2E-03","WT-2":"6.9E-03","WT-3":"8.3E-03","WT-4":"2.1E-03","AC-1":"2.5E-03","AC-2":"3.9E-03","AC-3":"8.4E-03","AC-4":"2.3E-03","AT-1":"6.9E-03","AT-2":"4.9E-03","AT-3":"7.6E-03","AT-4":"7.6E-03"},{"Metabolite":"2-Isopropylmalic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"8.1E-05","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"2-Methylserine","WC-1":"2.9E-04","WC-2":"3.2E-04","WC-3":"3.3E-04","WC-4":"3.2E-04","WT-1":"2.6E-04","WT-2":"2.7E-04","WT-3":"3.5E-04","WT-4":"3.9E-04","AC-1":"2.5E-04","AC-2":"2.3E-04","AC-3":"1.9E-04","AC-4":"2.9E-04","AT-1":"3.6E-04","AT-2":"3.1E-04","AT-3":"2.7E-04","AT-4":"2.7E-04"},{"Metabolite":"2-Oxoglutaric acid","WC-1":"1.1E-02","WC-2":"1.2E-02","WC-3":"1.5E-02","WC-4":"1.2E-02","WT-1":"2.8E-02","WT-2":"2.5E-02","WT-3":"3.2E-02","WT-4":"1.8E-02","AC-1":"1.4E-02","AC-2":"1.9E-02","AC-3":"7.0E-03","AC-4":"5.4E-03","AT-1":"2.7E-02","AT-2":"2.3E-02","AT-3":"3.1E-02","AT-4":"3.0E-02"},{"Metabolite":"2-Oxoisovaleric acid","WC-1":"2.3E-03","WC-2":"3.0E-03","WC-3":"2.6E-03","WC-4":"2.4E-03","WT-1":"2.1E-03","WT-2":"2.2E-03","WT-3":"1.8E-03","WT-4":"1.8E-03","AC-1":"1.9E-03","AC-2":"2.5E-03","AC-3":"3.6E-03","AC-4":"2.2E-03","AT-1":"2.8E-03","AT-2":"2.2E-03","AT-3":"1.9E-03","AT-4":"3.4E-03"},{"Metabolite":"3-(4-Hydroxyphenyl)propionic acid　3-(3-Hydroxyphenyl)propionic acid　2-(4-Hydroxyphenyl)propionic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"4.5E-04","WT-2":"2.4E-04","WT-3":"3.9E-04","WT-4":"5.7E-04","AC-1":"4.4E-04","AC-2":"4.5E-04","AC-3":"N.D.","AC-4":"3.1E-04","AT-1":"5.3E-04","AT-2":"3.0E-04","AT-3":"4.5E-04","AT-4":"4.4E-04"},{"Metabolite":"3-Amino-2-piperidone","WC-1":"1.3E-04","WC-2":"8.4E-05","WC-3":"8.0E-05","WC-4":"1.6E-04","WT-1":"1.4E-04","WT-2":"1.0E-04","WT-3":"1.1E-04","WT-4":"2.0E-04","AC-1":"1.4E-04","AC-2":"1.4E-04","AC-3":"1.7E-04","AC-4":"1.6E-04","AT-1":"1.7E-04","AT-2":"1.8E-04","AT-3":"1.4E-04","AT-4":"1.4E-04"},{"Metabolite":"3-Aminobutyric acid","WC-1":"N.D.","WC-2":"1.3E-04","WC-3":"2.1E-04","WC-4":"N.D.","WT-1":"N.D.","WT-2":"1.3E-04","WT-3":"N.D.","WT-4":"N.D.","AC-1":"1.5E-04","AC-2":"1.9E-04","AC-3":"2.2E-04","AC-4":"N.D.","AT-1":"1.9E-04","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"3-Guanidinopropionic acid","WC-1":"2.8E-05","WC-2":"N.D.","WC-3":"3.0E-05","WC-4":"4.7E-05","WT-1":"5.2E-05","WT-2":"3.5E-05","WT-3":"6.8E-05","WT-4":"8.0E-05","AC-1":"2.1E-05","AC-2":"2.7E-05","AC-3":"N.D.","AC-4":"N.D.","AT-1":"5.8E-05","AT-2":"4.5E-05","AT-3":"6.1E-05","AT-4":"2.8E-05"},{"Metabolite":"3-Hydroxy-2-methyl-4-pyrone","WC-1":"1.5E-01","WC-2":"1.6E-01","WC-3":"1.8E-01","WC-4":"1.5E-01","WT-1":"1.5E-01","WT-2":"1.5E-01","WT-3":"1.9E-01","WT-4":"1.8E-01","AC-1":"1.3E-01","AC-2":"1.3E-01","AC-3":"1.6E-01","AC-4":"1.7E-01","AT-1":"2.0E-01","AT-2":"2.0E-01","AT-3":"1.9E-01","AT-4":"1.8E-01"},{"Metabolite":"3-Hydroxy-3-methylglutaric acid","WC-1":"5.2E-04","WC-2":"3.3E-04","WC-3":"5.6E-04","WC-4":"3.4E-04","WT-1":"6.5E-04","WT-2":"6.0E-04","WT-3":"7.8E-04","WT-4":"7.7E-04","AC-1":"3.1E-04","AC-2":"N.D.","AC-3":"2.8E-04","AC-4":"3.8E-04","AT-1":"5.6E-04","AT-2":"7.2E-04","AT-3":"5.2E-04","AT-4":"6.1E-04"},{"Metabolite":"3-Hydroxybutyric acid","WC-1":"6.9E-02","WC-2":"1.9E-02","WC-3":"4.8E-02","WC-4":"3.8E-02","WT-1":"4.1E-02","WT-2":"3.8E-02","WT-3":"4.0E-02","WT-4":"6.0E-02","AC-1":"5.7E-02","AC-2":"3.7E-02","AC-3":"1.8E-02","AC-4":"4.8E-02","AT-1":"4.0E-02","AT-2":"5.8E-02","AT-3":"3.4E-02","AT-4":"4.3E-02"},{"Metabolite":"3-Hydroxykynurenine","WC-1":"2.1E-04","WC-2":"1.7E-04","WC-3":"9.5E-05","WC-4":"1.6E-04","WT-1":"2.1E-04","WT-2":"2.0E-04","WT-3":"2.1E-04","WT-4":"2.0E-04","AC-1":"1.9E-04","AC-2":"1.7E-04","AC-3":"2.3E-04","AC-4":"1.5E-04","AT-1":"2.6E-04","AT-2":"1.6E-04","AT-3":"2.6E-04","AT-4":"2.5E-04"},{"Metabolite":"3-Indoxylsulfuric acid","WC-1":"2.4E-02","WC-2":"8.0E-03","WC-3":"7.3E-03","WC-4":"2.7E-02","WT-1":"2.7E-02","WT-2":"1.0E-02","WT-3":"1.7E-02","WT-4":"5.5E-02","AC-1":"1.6E-02","AC-2":"1.9E-02","AC-3":"7.1E-03","AC-4":"1.9E-02","AT-1":"3.4E-02","AT-2":"2.4E-02","AT-3":"1.5E-02","AT-4":"1.5E-02"},{"Metabolite":"3-Methoxytyrosine","WC-1":"2.2E-04","WC-2":"1.5E-04","WC-3":"1.2E-04","WC-4":"1.9E-04","WT-1":"1.4E-04","WT-2":"1.4E-04","WT-3":"1.5E-04","WT-4":"1.6E-04","AC-1":"1.3E-04","AC-2":"1.7E-04","AC-3":"9.5E-05","AC-4":"1.7E-04","AT-1":"1.5E-04","AT-2":"2.2E-04","AT-3":"2.0E-04","AT-4":"1.6E-04"},{"Metabolite":"3-Methyladenine","WC-1":"2.1E-05","WC-2":"1.6E-05","WC-3":"N.D.","WC-4":"2.9E-05","WT-1":"2.5E-05","WT-2":"8.6E-06","WT-3":"1.8E-05","WT-4":"7.5E-05","AC-1":"1.4E-05","AC-2":"1.4E-05","AC-3":"9.0E-06","AC-4":"2.2E-05","AT-1":"1.6E-05","AT-2":"1.9E-05","AT-3":"1.5E-05","AT-4":"2.0E-05"},{"Metabolite":"3-Methylhistamine","WC-1":"1.4E-04","WC-2":"8.5E-05","WC-3":"3.3E-05","WC-4":"7.5E-05","WT-1":"9.1E-05","WT-2":"9.2E-05","WT-3":"7.8E-05","WT-4":"2.7E-04","AC-1":"6.7E-05","AC-2":"1.0E-04","AC-3":"2.4E-04","AC-4":"1.6E-04","AT-1":"1.5E-04","AT-2":"6.3E-05","AT-3":"8.7E-05","AT-4":"7.0E-05"},{"Metabolite":"3-Methylhistidine　1-Methylhistidine","WC-1":"2.5E-02","WC-2":"3.9E-02","WC-3":"3.8E-02","WC-4":"2.4E-02","WT-1":"2.0E-02","WT-2":"2.4E-02","WT-3":"2.9E-02","WT-4":"2.0E-02","AC-1":"2.0E-02","AC-2":"3.0E-02","AC-3":"4.8E-02","AC-4":"3.2E-02","AT-1":"3.6E-02","AT-2":"2.9E-02","AT-3":"3.3E-02","AT-4":"3.1E-02"},{"Metabolite":"3-Phenylpropionic acid","WC-1":"1.6E-03","WC-2":"1.6E-03","WC-3":"8.6E-04","WC-4":"1.2E-03","WT-1":"4.1E-03","WT-2":"3.5E-03","WT-3":"2.7E-03","WT-4":"2.4E-03","AC-1":"3.8E-03","AC-2":"5.5E-03","AC-3":"2.7E-03","AC-4":"3.3E-03","AT-1":"4.3E-03","AT-2":"2.9E-03","AT-3":"6.4E-03","AT-4":"6.7E-03"},{"Metabolite":"3-Phosphoglyceric acid","WC-1":"3.2E-04","WC-2":"5.4E-04","WC-3":"5.6E-04","WC-4":"4.3E-04","WT-1":"4.1E-04","WT-2":"6.7E-04","WT-3":"1.9E-04","WT-4":"7.6E-04","AC-1":"4.8E-04","AC-2":"5.5E-04","AC-3":"9.6E-04","AC-4":"4.9E-04","AT-1":"N.D.","AT-2":"5.5E-04","AT-3":"5.8E-04","AT-4":"3.6E-04"},{"Metabolite":"3-Ureidopropionic acid","WC-1":"3.0E-04","WC-2":"1.7E-04","WC-3":"1.5E-04","WC-4":"2.0E-04","WT-1":"3.1E-04","WT-2":"2.0E-04","WT-3":"2.4E-04","WT-4":"4.7E-04","AC-1":"1.8E-04","AC-2":"2.1E-04","AC-3":"1.8E-04","AC-4":"2.2E-04","AT-1":"2.2E-04","AT-2":"2.5E-04","AT-3":"1.9E-04","AT-4":"1.5E-04"},{"Metabolite":"4-(β-Acetylaminoethyl)imidazole","WC-1":"4.8E-06","WC-2":"N.D.","WC-3":"4.7E-06","WC-4":"N.D.","WT-1":"1.7E-05","WT-2":"4.8E-06","WT-3":"1.9E-05","WT-4":"1.6E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"5.2E-06","AC-4":"8.3E-06","AT-1":"5.2E-06","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"4-Acetamidobutanoic acid","WC-1":"2.2E-03","WC-2":"1.7E-03","WC-3":"3.2E-03","WC-4":"2.0E-03","WT-1":"4.5E-03","WT-2":"3.6E-03","WT-3":"1.8E-02","WT-4":"4.4E-03","AC-1":"9.2E-04","AC-2":"7.6E-04","AC-3":"1.8E-04","AC-4":"2.0E-03","AT-1":"1.0E-02","AT-2":"3.6E-03","AT-3":"3.4E-03","AT-4":"1.6E-03"},{"Metabolite":"4-Aminohippuric acid","WC-1":"8.2E-05","WC-2":"5.4E-05","WC-3":"1.3E-04","WC-4":"8.5E-05","WT-1":"1.1E-04","WT-2":"5.8E-05","WT-3":"6.7E-05","WT-4":"1.0E-04","AC-1":"5.7E-05","AC-2":"3.4E-05","AC-3":"1.6E-05","AC-4":"4.4E-05","AT-1":"1.1E-04","AT-2":"1.2E-04","AT-3":"9.5E-05","AT-4":"8.1E-05"},{"Metabolite":"4-Guanidinobutyric acid","WC-1":"3.9E-03","WC-2":"1.7E-03","WC-3":"1.7E-03","WC-4":"4.5E-03","WT-1":"6.0E-03","WT-2":"4.6E-03","WT-3":"9.9E-03","WT-4":"8.5E-03","AC-1":"2.1E-03","AC-2":"1.2E-03","AC-3":"7.7E-04","AC-4":"3.2E-03","AT-1":"6.5E-03","AT-2":"4.6E-03","AT-3":"4.8E-03","AT-4":"3.1E-03"},{"Metabolite":"4-Hydroxy-3-methoxyphenylglycol sulfate","WC-1":"1.9E-04","WC-2":"4.7E-05","WC-3":"8.2E-05","WC-4":"1.2E-04","WT-1":"9.6E-05","WT-2":"N.D.","WT-3":"6.8E-05","WT-4":"2.1E-04","AC-1":"9.8E-05","AC-2":"6.9E-05","AC-3":"N.D.","AC-4":"8.7E-05","AT-1":"1.0E-04","AT-2":"1.2E-04","AT-3":"6.1E-05","AT-4":"7.6E-05"},{"Metabolite":"4-Methyl-2-oxovaleric acid　3-Methyl-2-oxovaleric acid　2-Oxohexanoic acid","WC-1":"7.5E-03","WC-2":"8.2E-03","WC-3":"8.6E-03","WC-4":"6.5E-03","WT-1":"6.4E-03","WT-2":"7.4E-03","WT-3":"6.4E-03","WT-4":"6.7E-03","AC-1":"7.9E-03","AC-2":"8.6E-03","AC-3":"1.2E-02","AC-4":"7.3E-03","AT-1":"1.0E-02","AT-2":"6.8E-03","AT-3":"6.3E-03","AT-4":"9.8E-03"},{"Metabolite":"4-Methyl-5-thiazoleethanol","WC-1":"9.3E-06","WC-2":"2.0E-05","WC-3":"9.3E-06","WC-4":"9.1E-06","WT-1":"2.9E-05","WT-2":"2.7E-05","WT-3":"2.0E-05","WT-4":"N.D.","AC-1":"4.9E-05","AC-2":"4.1E-05","AC-3":"2.8E-05","AC-4":"1.9E-05","AT-1":"2.4E-05","AT-2":"3.1E-05","AT-3":"4.7E-05","AT-4":"6.1E-05"},{"Metabolite":"4-Oxopyrrolidine-2-carboxylic acid","WC-1":"4.7E-03","WC-2":"6.2E-03","WC-3":"4.5E-03","WC-4":"6.8E-03","WT-1":"1.0E-02","WT-2":"8.2E-03","WT-3":"6.6E-03","WT-4":"7.5E-03","AC-1":"1.4E-02","AC-2":"1.1E-02","AC-3":"8.8E-03","AC-4":"7.4E-03","AT-1":"9.2E-03","AT-2":"7.9E-03","AT-3":"1.2E-02","AT-4":"1.2E-02"},{"Metabolite":"4-Pyridoxic acid","WC-1":"2.2E-04","WC-2":"1.0E-04","WC-3":"1.7E-04","WC-4":"1.6E-04","WT-1":"2.3E-04","WT-2":"1.9E-04","WT-3":"4.0E-04","WT-4":"4.8E-04","AC-1":"1.9E-04","AC-2":"1.9E-04","AC-3":"N.D.","AC-4":"1.7E-04","AT-1":"2.8E-04","AT-2":"2.6E-04","AT-3":"2.2E-04","AT-4":"1.4E-04"},{"Metabolite":"5'-Deoxy-5'-methylthioadenosine","WC-1":"5.3E-05","WC-2":"6.9E-05","WC-3":"8.1E-05","WC-4":"5.4E-05","WT-1":"6.4E-05","WT-2":"8.7E-05","WT-3":"7.5E-05","WT-4":"9.4E-05","AC-1":"6.0E-05","AC-2":"6.4E-05","AC-3":"6.4E-05","AC-4":"6.3E-05","AT-1":"7.4E-05","AT-2":"9.9E-05","AT-3":"7.4E-05","AT-4":"6.1E-05"},{"Metabolite":"5-Amino-4-oxovaleric acid","WC-1":"2.1E-04","WC-2":"2.3E-04","WC-3":"2.4E-04","WC-4":"1.9E-04","WT-1":"1.8E-04","WT-2":"2.9E-04","WT-3":"3.9E-04","WT-4":"2.7E-04","AC-1":"1.6E-04","AC-2":"1.8E-04","AC-3":"2.0E-04","AC-4":"2.0E-04","AT-1":"3.3E-04","AT-2":"3.1E-04","AT-3":"2.6E-04","AT-4":"2.3E-04"},{"Metabolite":"5-Aminoindole","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"1.6E-05","WT-4":"N.D.","AC-1":"N.D.","AC-2":"4.4E-05","AC-3":"8.5E-05","AC-4":"4.7E-05","AT-1":"1.0E-04","AT-2":"N.D.","AT-3":"7.2E-05","AT-4":"3.6E-05"},{"Metabolite":"5-Aminovaleric acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"5.3E-03","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"5-Hydroxyindoleacetic acid","WC-1":"5.2E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"8.6E-05","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"6.6E-05","AC-1":"7.0E-05","AC-2":"3.9E-05","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"5-Hydroxylysine","WC-1":"1.5E-03","WC-2":"1.9E-03","WC-3":"1.2E-03","WC-4":"1.8E-03","WT-1":"1.7E-03","WT-2":"1.5E-03","WT-3":"1.9E-03","WT-4":"2.3E-03","AC-1":"1.5E-03","AC-2":"2.0E-03","AC-3":"3.2E-03","AC-4":"1.5E-03","AT-1":"2.1E-03","AT-2":"1.7E-03","AT-3":"1.6E-03","AT-4":"1.6E-03"},{"Metabolite":"5-Hydroxypentanoic acid","WC-1":"N.D.","WC-2":"4.5E-04","WC-3":"N.D.","WC-4":"N.D.","WT-1":"9.3E-04","WT-2":"7.0E-04","WT-3":"N.D.","WT-4":"1.1E-03","AC-1":"N.D.","AC-2":"6.5E-04","AC-3":"N.D.","AC-4":"N.D.","AT-1":"8.3E-04","AT-2":"N.D.","AT-3":"7.1E-04","AT-4":"N.D."},{"Metabolite":"5-Methoxyindoleacetic acid　Indole-3-lactic acid","WC-1":"9.7E-04","WC-2":"6.8E-04","WC-3":"6.3E-04","WC-4":"8.9E-04","WT-1":"1.1E-03","WT-2":"8.5E-04","WT-3":"1.1E-03","WT-4":"1.6E-03","AC-1":"9.9E-04","AC-2":"1.1E-03","AC-3":"5.9E-04","AC-4":"9.6E-04","AT-1":"1.1E-03","AT-2":"1.2E-03","AT-3":"8.4E-04","AT-4":"7.8E-04"},{"Metabolite":"5-Methyl-2'-deoxycytidine","WC-1":"2.0E-04","WC-2":"2.1E-04","WC-3":"2.3E-04","WC-4":"2.0E-04","WT-1":"1.7E-04","WT-2":"1.5E-04","WT-3":"1.4E-04","WT-4":"1.5E-04","AC-1":"1.7E-04","AC-2":"1.9E-04","AC-3":"1.6E-04","AC-4":"1.6E-04","AT-1":"1.4E-04","AT-2":"2.1E-04","AT-3":"1.6E-04","AT-4":"1.4E-04"},{"Metabolite":"5-Methylcytosine","WC-1":"3.4E-05","WC-2":"1.8E-05","WC-3":"1.2E-05","WC-4":"3.7E-05","WT-1":"3.2E-05","WT-2":"2.7E-05","WT-3":"6.6E-05","WT-4":"9.5E-05","AC-1":"1.8E-05","AC-2":"2.4E-05","AC-3":"N.D.","AC-4":"1.4E-05","AT-1":"1.7E-05","AT-2":"1.2E-05","AT-3":"3.2E-05","AT-4":"1.3E-05"},{"Metabolite":"5-Oxoproline","WC-1":"2.7E-03","WC-2":"2.1E-03","WC-3":"2.1E-03","WC-4":"2.3E-03","WT-1":"3.1E-03","WT-2":"3.1E-03","WT-3":"2.9E-03","WT-4":"3.6E-03","AC-1":"2.6E-03","AC-2":"4.1E-03","AC-3":"2.8E-03","AC-4":"2.7E-03","AT-1":"3.0E-03","AT-2":"3.3E-03","AT-3":"3.0E-03","AT-4":"3.3E-03"},{"Metabolite":"6-Aminohexanoic acid","WC-1":"N.D.","WC-2":"2.0E-03","WC-3":"2.7E-03","WC-4":"1.7E-04","WT-1":"1.3E-03","WT-2":"1.7E-03","WT-3":"2.9E-03","WT-4":"N.D.","AC-1":"N.D.","AC-2":"4.6E-04","AC-3":"2.0E-03","AC-4":"N.D.","AT-1":"1.4E-03","AT-2":"7.6E-04","AT-3":"1.9E-03","AT-4":"1.6E-03"},{"Metabolite":"6-Hydroxyhexanoic acid","WC-1":"3.5E-04","WC-2":"1.2E-04","WC-3":"1.7E-04","WC-4":"2.5E-04","WT-1":"N.D.","WT-2":"2.3E-04","WT-3":"3.7E-04","WT-4":"2.8E-04","AC-1":"6.4E-04","AC-2":"2.3E-04","AC-3":"1.3E-04","AC-4":"3.8E-04","AT-1":"3.0E-04","AT-2":"3.3E-04","AT-3":"2.3E-04","AT-4":"3.0E-04"},{"Metabolite":"6-Phosphogluconic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"1.0E-04","WC-4":"N.D.","WT-1":"N.D.","WT-2":"4.7E-05","WT-3":"N.D.","WT-4":"1.7E-04","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"7,8-Dihydrobiopterin","WC-1":"3.4E-04","WC-2":"3.3E-04","WC-3":"4.5E-04","WC-4":"2.8E-04","WT-1":"4.1E-04","WT-2":"4.1E-04","WT-3":"4.6E-04","WT-4":"6.0E-04","AC-1":"3.1E-04","AC-2":"3.3E-04","AC-3":"3.0E-04","AC-4":"4.3E-04","AT-1":"5.2E-04","AT-2":"4.5E-04","AT-3":"3.9E-04","AT-4":"3.8E-04"},{"Metabolite":"7-Methylguanine","WC-1":"3.5E-04","WC-2":"2.4E-04","WC-3":"3.4E-04","WC-4":"2.9E-04","WT-1":"2.4E-04","WT-2":"2.3E-04","WT-3":"2.6E-04","WT-4":"3.7E-04","AC-1":"2.6E-04","AC-2":"2.4E-04","AC-3":"1.8E-04","AC-4":"3.4E-04","AT-1":"2.7E-04","AT-2":"3.3E-04","AT-3":"2.7E-04","AT-4":"2.3E-04"},{"Metabolite":"8-Hydroxyoctanoic acid","WC-1":"1.6E-04","WC-2":"9.8E-05","WC-3":"2.0E-04","WC-4":"1.2E-04","WT-1":"1.9E-04","WT-2":"1.5E-04","WT-3":"1.6E-04","WT-4":"1.7E-04","AC-1":"3.5E-04","AC-2":"1.1E-04","AC-3":"N.D.","AC-4":"1.5E-04","AT-1":"1.2E-04","AT-2":"1.9E-04","AT-3":"1.8E-04","AT-4":"1.7E-04"},{"Metabolite":"Acetoacetamide","WC-1":"5.1E-04","WC-2":"6.8E-04","WC-3":"4.7E-04","WC-4":"5.1E-04","WT-1":"5.0E-04","WT-2":"4.6E-04","WT-3":"5.5E-04","WT-4":"5.6E-04","AC-1":"4.3E-04","AC-2":"6.6E-04","AC-3":"5.8E-04","AC-4":"5.1E-04","AT-1":"7.1E-04","AT-2":"6.1E-04","AT-3":"4.6E-04","AT-4":"4.0E-04"},{"Metabolite":"Acetoacetic acid","WC-1":"9.3E-04","WC-2":"N.D.","WC-3":"N.D.","WC-4":"7.0E-04","WT-1":"N.D.","WT-2":"6.8E-04","WT-3":"N.D.","WT-4":"7.7E-04","AC-1":"8.9E-04","AC-2":"7.5E-04","AC-3":"N.D.","AC-4":"7.9E-04","AT-1":"6.7E-04","AT-2":"8.3E-04","AT-3":"5.9E-04","AT-4":"9.0E-04"},{"Metabolite":"Adenosine","WC-1":"2.5E-05","WC-2":"1.5E-05","WC-3":"1.4E-05","WC-4":"5.3E-05","WT-1":"4.0E-05","WT-2":"2.9E-05","WT-3":"8.7E-05","WT-4":"9.5E-05","AC-1":"2.2E-05","AC-2":"1.7E-05","AC-3":"N.D.","AC-4":"3.9E-05","AT-1":"1.9E-05","AT-2":"3.1E-05","AT-3":"6.8E-05","AT-4":"2.5E-05"},{"Metabolite":"Adipic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"5.8E-04","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"ADMA","WC-1":"3.7E-03","WC-2":"3.1E-03","WC-3":"2.8E-03","WC-4":"3.6E-03","WT-1":"2.7E-03","WT-2":"2.4E-03","WT-3":"2.3E-03","WT-4":"2.9E-03","AC-1":"3.7E-03","AC-2":"3.8E-03","AC-3":"3.4E-03","AC-4":"4.3E-03","AT-1":"3.4E-03","AT-2":"3.8E-03","AT-3":"3.4E-03","AT-4":"3.2E-03"},{"Metabolite":"ADP","WC-1":"1.8E-03","WC-2":"5.7E-04","WC-3":"2.4E-04","WC-4":"4.1E-04","WT-1":"7.1E-04","WT-2":"1.1E-03","WT-3":"5.2E-04","WT-4":"3.9E-03","AC-1":"6.0E-04","AC-2":"1.2E-03","AC-3":"1.7E-03","AC-4":"1.2E-03","AT-1":"1.0E-03","AT-2":"9.0E-04","AT-3":"7.4E-04","AT-4":"7.0E-04"},{"Metabolite":"ADP-ribose","WC-1":"1.2E-04","WC-2":"6.5E-05","WC-3":"9.4E-05","WC-4":"1.6E-04","WT-1":"9.7E-05","WT-2":"1.1E-04","WT-3":"1.1E-04","WT-4":"3.9E-04","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"8.0E-05","AT-3":"7.1E-05","AT-4":"N.D."},{"Metabolite":"Adrenaline","WC-1":"2.5E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"3.8E-05","WT-2":"4.1E-05","WT-3":"1.2E-04","WT-4":"4.0E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Ala","WC-1":"2.0E-01","WC-2":"2.5E-01","WC-3":"1.5E-01","WC-4":"1.9E-01","WT-1":"1.7E-01","WT-2":"1.6E-01","WT-3":"1.8E-01","WT-4":"2.1E-01","AC-1":"3.0E-01","AC-2":"2.8E-01","AC-3":"3.4E-01","AC-4":"2.1E-01","AT-1":"2.6E-01","AT-2":"2.0E-01","AT-3":"2.8E-01","AT-4":"2.5E-01"},{"Metabolite":"Albizziine","WC-1":"N.D.","WC-2":"1.2E-05","WC-3":"2.5E-05","WC-4":"9.5E-06","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"5.9E-05","AC-4":"N.D.","AT-1":"N.D.","AT-2":"8.9E-06","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Allantoic acid","WC-1":"N.D.","WC-2":"3.1E-05","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"3.5E-05","WT-4":"6.1E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"4.9E-05","AT-1":"6.4E-05","AT-2":"N.D.","AT-3":"6.1E-05","AT-4":"N.D."},{"Metabolite":"Allantoin","WC-1":"2.5E-02","WC-2":"2.7E-02","WC-3":"2.7E-02","WC-4":"2.3E-02","WT-1":"1.8E-02","WT-2":"1.7E-02","WT-3":"2.0E-02","WT-4":"2.4E-02","AC-1":"2.2E-02","AC-2":"2.3E-02","AC-3":"3.1E-02","AC-4":"2.7E-02","AT-1":"3.1E-02","AT-2":"3.3E-02","AT-3":"2.8E-02","AT-4":"2.6E-02"},{"Metabolite":"AMP","WC-1":"1.1E-03","WC-2":"5.5E-04","WC-3":"3.8E-04","WC-4":"4.3E-04","WT-1":"6.6E-04","WT-2":"6.4E-04","WT-3":"4.6E-04","WT-4":"4.1E-03","AC-1":"5.2E-04","AC-2":"9.7E-04","AC-3":"1.6E-03","AC-4":"8.0E-04","AT-1":"1.0E-03","AT-2":"6.5E-04","AT-3":"6.6E-04","AT-4":"6.0E-04"},{"Metabolite":"Anserine_divalent","WC-1":"2.5E-03","WC-2":"7.2E-03","WC-3":"5.7E-03","WC-4":"2.6E-03","WT-1":"3.7E-03","WT-2":"7.0E-03","WT-3":"5.9E-03","WT-4":"3.4E-03","AC-1":"3.6E-03","AC-2":"5.9E-03","AC-3":"1.5E-02","AC-4":"4.3E-03","AT-1":"6.8E-03","AT-2":"4.2E-03","AT-3":"8.6E-03","AT-4":"8.4E-03"},{"Metabolite":"Anthranilic acid","WC-1":"1.4E-04","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"1.5E-04","WT-2":"N.D.","WT-3":"1.4E-04","WT-4":"1.9E-04","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"2.0E-04","AT-3":"N.D.","AT-4":"1.6E-04"},{"Metabolite":"Arg","WC-1":"2.4E-01","WC-2":"2.2E-01","WC-3":"1.7E-01","WC-4":"2.8E-01","WT-1":"2.3E-01","WT-2":"1.7E-01","WT-3":"2.0E-01","WT-4":"2.5E-01","AC-1":"2.7E-01","AC-2":"3.1E-01","AC-3":"3.5E-01","AC-4":"3.0E-01","AT-1":"2.9E-01","AT-2":"2.5E-01","AT-3":"2.0E-01","AT-4":"1.8E-01"},{"Metabolite":"Argininosuccinic acid","WC-1":"8.3E-04","WC-2":"6.2E-04","WC-3":"7.2E-04","WC-4":"7.9E-04","WT-1":"8.1E-04","WT-2":"6.5E-04","WT-3":"8.5E-04","WT-4":"1.1E-03","AC-1":"7.1E-04","AC-2":"7.7E-04","AC-3":"7.2E-04","AC-4":"6.9E-04","AT-1":"1.1E-03","AT-2":"9.7E-04","AT-3":"9.1E-04","AT-4":"6.5E-04"},{"Metabolite":"Ascorbate 2-phosphate","WC-1":"N.D.","WC-2":"6.8E-05","WC-3":"N.D.","WC-4":"5.3E-05","WT-1":"5.9E-05","WT-2":"N.D.","WT-3":"6.4E-05","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"7.5E-05","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Ascorbate 2-sulfate","WC-1":"2.9E-04","WC-2":"2.8E-04","WC-3":"4.0E-04","WC-4":"2.9E-04","WT-1":"1.8E-04","WT-2":"1.8E-04","WT-3":"1.8E-04","WT-4":"2.8E-04","AC-1":"3.7E-04","AC-2":"2.7E-04","AC-3":"2.1E-04","AC-4":"4.5E-04","AT-1":"2.9E-04","AT-2":"3.2E-04","AT-3":"1.9E-04","AT-4":"2.4E-04"},{"Metabolite":"Asn","WC-1":"4.0E-02","WC-2":"4.5E-02","WC-3":"2.9E-02","WC-4":"4.1E-02","WT-1":"5.6E-02","WT-2":"4.2E-02","WT-3":"2.6E-02","WT-4":"3.1E-02","AC-1":"9.4E-02","AC-2":"7.5E-02","AC-3":"5.8E-02","AC-4":"4.5E-02","AT-1":"4.5E-02","AT-2":"5.1E-02","AT-3":"7.9E-02","AT-4":"7.4E-02"},{"Metabolite":"Asp","WC-1":"3.9E-03","WC-2":"7.2E-03","WC-3":"4.5E-03","WC-4":"6.2E-03","WT-1":"8.2E-03","WT-2":"7.5E-03","WT-3":"4.8E-03","WT-4":"8.0E-03","AC-1":"1.7E-02","AC-2":"1.9E-02","AC-3":"1.1E-02","AC-4":"6.8E-03","AT-1":"9.1E-03","AT-2":"7.4E-03","AT-3":"1.5E-02","AT-4":"1.2E-02"},{"Metabolite":"ATP","WC-1":"2.5E-03","WC-2":"7.4E-04","WC-3":"5.9E-04","WC-4":"5.0E-04","WT-1":"1.0E-03","WT-2":"1.3E-03","WT-3":"8.6E-04","WT-4":"3.3E-03","AC-1":"7.7E-04","AC-2":"1.2E-03","AC-3":"1.9E-03","AC-4":"1.5E-03","AT-1":"1.5E-03","AT-2":"1.2E-03","AT-3":"1.0E-03","AT-4":"8.7E-04"},{"Metabolite":"Azelaic acid","WC-1":"3.0E-04","WC-2":"1.5E-04","WC-3":"N.D.","WC-4":"2.5E-04","WT-1":"2.6E-04","WT-2":"2.0E-04","WT-3":"2.0E-04","WT-4":"3.8E-04","AC-1":"2.2E-04","AC-2":"2.0E-04","AC-3":"1.8E-04","AC-4":"N.D.","AT-1":"2.8E-04","AT-2":"2.8E-04","AT-3":"3.2E-04","AT-4":"2.1E-04"},{"Metabolite":"Azetidine 2-carboxylic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"1.5E-04","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Betaine","WC-1":"2.3E-01","WC-2":"2.3E-01","WC-3":"1.9E-01","WC-4":"2.2E-01","WT-1":"2.4E-01","WT-2":"2.0E-01","WT-3":"2.1E-01","WT-4":"2.5E-01","AC-1":"4.1E-01","AC-2":"3.6E-01","AC-3":"3.2E-01","AC-4":"3.1E-01","AT-1":"2.7E-01","AT-2":"2.8E-01","AT-3":"3.4E-01","AT-4":"3.3E-01"},{"Metabolite":"Betonicine","WC-1":"2.7E-04","WC-2":"2.7E-04","WC-3":"1.9E-04","WC-4":"2.5E-04","WT-1":"1.8E-04","WT-2":"2.1E-04","WT-3":"N.D.","WT-4":"2.6E-04","AC-1":"3.3E-04","AC-2":"3.8E-04","AC-3":"2.8E-04","AC-4":"2.9E-04","AT-1":"3.1E-04","AT-2":"3.3E-04","AT-3":"3.5E-04","AT-4":"2.4E-04"},{"Metabolite":"Biopterin","WC-1":"4.2E-05","WC-2":"N.D.","WC-3":"2.1E-05","WC-4":"2.3E-05","WT-1":"1.2E-05","WT-2":"8.7E-06","WT-3":"2.7E-05","WT-4":"6.6E-05","AC-1":"2.2E-05","AC-2":"2.3E-05","AC-3":"2.7E-05","AC-4":"3.7E-05","AT-1":"3.7E-05","AT-2":"2.6E-05","AT-3":"2.7E-05","AT-4":"2.3E-05"},{"Metabolite":"Butyric acid　Isobutyric acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"4.2E-03","WT-2":"2.7E-03","WT-3":"1.5E-03","WT-4":"N.D.","AC-1":"3.1E-03","AC-2":"2.4E-03","AC-3":"N.D.","AC-4":"N.D.","AT-1":"7.9E-04","AT-2":"1.2E-03","AT-3":"2.4E-03","AT-4":"5.9E-03"},{"Metabolite":"Butyrylcarnitine","WC-1":"1.2E-02","WC-2":"6.3E-03","WC-3":"8.6E-03","WC-4":"1.4E-02","WT-1":"1.9E-02","WT-2":"1.7E-02","WT-3":"3.6E-02","WT-4":"3.2E-02","AC-1":"6.6E-03","AC-2":"5.1E-03","AC-3":"2.0E-03","AC-4":"1.4E-02","AT-1":"2.2E-02","AT-2":"1.9E-02","AT-3":"1.4E-02","AT-4":"1.5E-02"},{"Metabolite":"cAMP","WC-1":"3.3E-05","WC-2":"5.5E-05","WC-3":"N.D.","WC-4":"5.8E-05","WT-1":"N.D.","WT-2":"3.6E-05","WT-3":"N.D.","WT-4":"4.3E-05","AC-1":"9.4E-05","AC-2":"1.2E-04","AC-3":"1.1E-04","AC-4":"1.2E-04","AT-1":"9.2E-05","AT-2":"N.D.","AT-3":"6.4E-05","AT-4":"8.3E-05"},{"Metabolite":"Carboxymethyllysine","WC-1":"9.1E-04","WC-2":"7.3E-04","WC-3":"7.3E-04","WC-4":"7.6E-04","WT-1":"9.6E-04","WT-2":"8.7E-04","WT-3":"8.8E-04","WT-4":"1.4E-03","AC-1":"1.0E-03","AC-2":"9.7E-04","AC-3":"7.2E-04","AC-4":"1.1E-03","AT-1":"1.6E-03","AT-2":"1.2E-03","AT-3":"1.1E-03","AT-4":"1.1E-03"},{"Metabolite":"Carnitine","WC-1":"1.2E-01","WC-2":"1.5E-01","WC-3":"1.1E-01","WC-4":"1.2E-01","WT-1":"1.2E-01","WT-2":"1.2E-01","WT-3":"1.3E-01","WT-4":"1.6E-01","AC-1":"1.4E-01","AC-2":"1.6E-01","AC-3":"1.8E-01","AC-4":"1.7E-01","AT-1":"1.7E-01","AT-2":"1.5E-01","AT-3":"1.6E-01","AT-4":"1.6E-01"},{"Metabolite":"Carnosine","WC-1":"6.9E-04","WC-2":"9.5E-04","WC-3":"7.0E-04","WC-4":"5.1E-04","WT-1":"6.8E-04","WT-2":"9.3E-04","WT-3":"6.7E-04","WT-4":"9.2E-04","AC-1":"7.2E-04","AC-2":"9.7E-04","AC-3":"2.0E-03","AC-4":"1.0E-03","AT-1":"9.7E-04","AT-2":"8.0E-04","AT-3":"1.1E-03","AT-4":"1.3E-03"},{"Metabolite":"Cholic acid","WC-1":"9.1E-04","WC-2":"1.4E-04","WC-3":"5.7E-04","WC-4":"1.1E-03","WT-1":"2.4E-02","WT-2":"9.1E-04","WT-3":"4.4E-04","WT-4":"1.6E-03","AC-1":"7.2E-03","AC-2":"2.1E-02","AC-3":"6.0E-04","AC-4":"8.2E-04","AT-1":"1.1E-03","AT-2":"3.1E-03","AT-3":"1.3E-02","AT-4":"1.5E-02"},{"Metabolite":"Choline","WC-1":"9.7E-02","WC-2":"1.0E-01","WC-3":"1.3E-01","WC-4":"9.0E-02","WT-1":"1.0E-01","WT-2":"8.4E-02","WT-3":"1.5E-01","WT-4":"1.0E-01","AC-1":"9.1E-02","AC-2":"7.4E-02","AC-3":"5.9E-02","AC-4":"9.0E-02","AT-1":"1.3E-01","AT-2":"1.0E-01","AT-3":"1.3E-01","AT-4":"1.1E-01"},{"Metabolite":"cis-Aconitic acid","WC-1":"1.1E-02","WC-2":"8.6E-03","WC-3":"1.0E-02","WC-4":"1.0E-02","WT-1":"1.2E-02","WT-2":"1.2E-02","WT-3":"1.4E-02","WT-4":"1.7E-02","AC-1":"1.1E-02","AC-2":"1.2E-02","AC-3":"9.2E-03","AC-4":"1.1E-02","AT-1":"1.7E-02","AT-2":"1.6E-02","AT-3":"1.6E-02","AT-4":"1.4E-02"},{"Metabolite":"Citric acid","WC-1":"2.3E-01","WC-2":"1.9E-01","WC-3":"2.4E-01","WC-4":"2.0E-01","WT-1":"2.6E-01","WT-2":"2.6E-01","WT-3":"3.0E-01","WT-4":"2.7E-01","AC-1":"2.3E-01","AC-2":"2.6E-01","AC-3":"1.7E-01","AC-4":"2.0E-01","AT-1":"3.4E-01","AT-2":"3.1E-01","AT-3":"2.8E-01","AT-4":"3.1E-01"},{"Metabolite":"Citrulline","WC-1":"1.4E-01","WC-2":"9.6E-02","WC-3":"8.9E-02","WC-4":"1.2E-01","WT-1":"1.0E-01","WT-2":"8.8E-02","WT-3":"8.6E-02","WT-4":"1.2E-01","AC-1":"1.3E-01","AC-2":"1.2E-01","AC-3":"9.2E-02","AC-4":"1.3E-01","AT-1":"1.2E-01","AT-2":"1.3E-01","AT-3":"1.4E-01","AT-4":"1.1E-01"},{"Metabolite":"CMP","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"2.8E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"CMP-N-acetylneuraminate","WC-1":"1.7E-04","WC-2":"3.6E-04","WC-3":"1.1E-03","WC-4":"2.5E-04","WT-1":"8.9E-04","WT-2":"7.2E-04","WT-3":"1.8E-03","WT-4":"8.8E-04","AC-1":"7.6E-05","AC-2":"6.8E-05","AC-3":"N.D.","AC-4":"2.3E-04","AT-1":"7.6E-04","AT-2":"7.2E-04","AT-3":"8.3E-04","AT-4":"5.1E-04"},{"Metabolite":"Creatine","WC-1":"3.0E-01","WC-2":"3.2E-01","WC-3":"2.4E-01","WC-4":"3.0E-01","WT-1":"2.7E-01","WT-2":"2.7E-01","WT-3":"2.3E-01","WT-4":"2.7E-01","AC-1":"3.3E-01","AC-2":"3.5E-01","AC-3":"5.1E-01","AC-4":"4.0E-01","AT-1":"4.1E-01","AT-2":"3.9E-01","AT-3":"4.1E-01","AT-4":"3.6E-01"},{"Metabolite":"Creatinine","WC-1":"2.8E-02","WC-2":"2.3E-02","WC-3":"2.4E-02","WC-4":"2.3E-02","WT-1":"2.3E-02","WT-2":"2.4E-02","WT-3":"2.6E-02","WT-4":"2.9E-02","AC-1":"2.6E-02","AC-2":"2.5E-02","AC-3":"2.7E-02","AC-4":"3.2E-02","AT-1":"3.4E-02","AT-2":"3.3E-02","AT-3":"3.1E-02","AT-4":"2.9E-02"},{"Metabolite":"Cys","WC-1":"N.D.","WC-2":"8.8E-05","WC-3":"1.6E-04","WC-4":"N.D.","WT-1":"3.6E-05","WT-2":"6.6E-05","WT-3":"2.8E-05","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"1.7E-04","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"1.1E-04","AT-4":"1.1E-04"},{"Metabolite":"Cystathionine","WC-1":"2.9E-03","WC-2":"3.5E-03","WC-3":"3.2E-03","WC-4":"3.0E-03","WT-1":"2.7E-03","WT-2":"2.3E-03","WT-3":"2.5E-03","WT-4":"2.8E-03","AC-1":"2.3E-03","AC-2":"2.7E-03","AC-3":"2.6E-03","AC-4":"2.7E-03","AT-1":"3.1E-03","AT-2":"3.2E-03","AT-3":"3.9E-03","AT-4":"3.3E-03"},{"Metabolite":"Cysteine glutathione disulfide","WC-1":"2.0E-02","WC-2":"2.9E-02","WC-3":"5.0E-02","WC-4":"2.1E-02","WT-1":"3.1E-02","WT-2":"2.8E-02","WT-3":"4.1E-02","WT-4":"3.7E-02","AC-1":"1.5E-02","AC-2":"1.2E-02","AC-3":"8.1E-03","AC-4":"2.1E-02","AT-1":"3.4E-02","AT-2":"2.8E-02","AT-3":"3.3E-02","AT-4":"3.3E-02"},{"Metabolite":"Cystine","WC-1":"9.6E-03","WC-2":"2.5E-02","WC-3":"3.9E-02","WC-4":"7.4E-03","WT-1":"1.5E-02","WT-2":"1.6E-02","WT-3":"1.1E-02","WT-4":"8.6E-03","AC-1":"1.5E-02","AC-2":"2.6E-02","AC-3":"5.6E-02","AC-4":"1.3E-02","AT-1":"1.3E-02","AT-2":"7.9E-03","AT-3":"2.2E-02","AT-4":"2.9E-02"},{"Metabolite":"Cytidine","WC-1":"6.9E-03","WC-2":"8.6E-03","WC-3":"1.2E-02","WC-4":"6.0E-03","WT-1":"8.5E-03","WT-2":"8.8E-03","WT-3":"1.0E-02","WT-4":"6.5E-03","AC-1":"7.7E-03","AC-2":"5.7E-03","AC-3":"5.9E-03","AC-4":"8.3E-03","AT-1":"8.9E-03","AT-2":"9.6E-03","AT-3":"1.1E-02","AT-4":"9.4E-03"},{"Metabolite":"Decarboxylated S-Adenosylmethionine","WC-1":"9.8E-06","WC-2":"2.6E-05","WC-3":"4.0E-05","WC-4":"N.D.","WT-1":"2.5E-05","WT-2":"3.7E-05","WT-3":"7.4E-05","WT-4":"N.D.","AC-1":"6.4E-06","AC-2":"1.7E-05","AC-3":"N.D.","AC-4":"N.D.","AT-1":"6.0E-05","AT-2":"N.D.","AT-3":"3.0E-05","AT-4":"4.3E-05"},{"Metabolite":"dGDP","WC-1":"5.1E-05","WC-2":"6.2E-05","WC-3":"7.3E-05","WC-4":"4.0E-05","WT-1":"3.3E-05","WT-2":"6.4E-05","WT-3":"4.2E-05","WT-4":"4.6E-05","AC-1":"8.0E-05","AC-2":"2.7E-05","AC-3":"5.1E-05","AC-4":"5.7E-05","AT-1":"1.0E-04","AT-2":"8.9E-05","AT-3":"5.7E-05","AT-4":"6.2E-05"},{"Metabolite":"Diethanolamine","WC-1":"3.1E-03","WC-2":"5.6E-03","WC-3":"5.6E-03","WC-4":"2.4E-03","WT-1":"2.5E-03","WT-2":"6.0E-03","WT-3":"5.6E-03","WT-4":"2.9E-03","AC-1":"4.6E-03","AC-2":"3.8E-03","AC-3":"1.4E-02","AC-4":"4.3E-03","AT-1":"1.9E-02","AT-2":"3.3E-03","AT-3":"4.6E-03","AT-4":"7.2E-03"},{"Metabolite":"Dihydroorotic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"4.3E-05","WT-2":"N.D.","WT-3":"N.D.","WT-4":"7.0E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Dihydroxyacetone phosphate","WC-1":"N.D.","WC-2":"1.8E-04","WC-3":"N.D.","WC-4":"1.0E-04","WT-1":"1.6E-04","WT-2":"2.1E-04","WT-3":"N.D.","WT-4":"2.8E-04","AC-1":"1.8E-04","AC-2":"1.7E-04","AC-3":"2.0E-04","AC-4":"1.7E-04","AT-1":"2.6E-04","AT-2":"2.8E-04","AT-3":"1.7E-04","AT-4":"2.4E-04"},{"Metabolite":"Dodecanedioic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"1.1E-04","WT-2":"N.D.","WT-3":"N.D.","WT-4":"9.1E-05","AC-1":"1.1E-04","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"4.6E-05","AT-2":"N.D.","AT-3":"8.6E-05","AT-4":"8.2E-05"},{"Metabolite":"Ectoine","WC-1":"6.1E-03","WC-2":"3.0E-03","WC-3":"1.9E-03","WC-4":"7.1E-03","WT-1":"3.3E-03","WT-2":"2.5E-03","WT-3":"3.6E-03","WT-4":"5.4E-03","AC-1":"3.3E-03","AC-2":"6.7E-03","AC-3":"4.7E-03","AC-4":"4.3E-03","AT-1":"5.8E-03","AT-2":"4.2E-03","AT-3":"3.8E-03","AT-4":"3.1E-03"},{"Metabolite":"Ergothioneine","WC-1":"N.D.","WC-2":"6.6E-05","WC-3":"N.D.","WC-4":"N.D.","WT-1":"4.9E-05","WT-2":"4.9E-04","WT-3":"N.D.","WT-4":"1.3E-04","AC-1":"6.7E-04","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"6.6E-05","AT-3":"N.D.","AT-4":"4.5E-05"},{"Metabolite":"Ethanolamine","WC-1":"1.1E-03","WC-2":"1.5E-03","WC-3":"1.2E-03","WC-4":"1.0E-03","WT-1":"1.3E-03","WT-2":"1.1E-03","WT-3":"9.2E-04","WT-4":"1.3E-03","AC-1":"2.3E-03","AC-2":"1.6E-03","AC-3":"1.8E-03","AC-4":"1.6E-03","AT-1":"1.9E-03","AT-2":"1.8E-03","AT-3":"1.8E-03","AT-4":"1.9E-03"},{"Metabolite":"Ethanolamine phosphate","WC-1":"6.3E-04","WC-2":"1.0E-03","WC-3":"5.5E-04","WC-4":"7.4E-04","WT-1":"7.4E-04","WT-2":"9.2E-04","WT-3":"5.1E-04","WT-4":"9.6E-04","AC-1":"1.2E-03","AC-2":"1.8E-03","AC-3":"2.0E-03","AC-4":"1.3E-03","AT-1":"1.2E-03","AT-2":"6.4E-04","AT-3":"8.9E-04","AT-4":"1.0E-03"},{"Metabolite":"Ethionine","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"1.8E-05","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Ethyl glucuronide","WC-1":"8.7E-04","WC-2":"9.4E-04","WC-3":"9.6E-04","WC-4":"7.6E-04","WT-1":"7.3E-04","WT-2":"1.6E-03","WT-3":"1.5E-03","WT-4":"5.1E-04","AC-1":"1.1E-03","AC-2":"1.1E-03","AC-3":"1.6E-03","AC-4":"7.2E-04","AT-1":"8.8E-04","AT-2":"9.3E-04","AT-3":"1.2E-03","AT-4":"1.0E-03"},{"Metabolite":"FAD_divalent","WC-1":"1.1E-04","WC-2":"7.0E-05","WC-3":"1.6E-04","WC-4":"1.1E-04","WT-1":"1.3E-04","WT-2":"1.1E-04","WT-3":"1.4E-04","WT-4":"1.3E-04","AC-1":"5.8E-05","AC-2":"8.9E-05","AC-3":"2.3E-04","AC-4":"1.1E-04","AT-1":"9.5E-05","AT-2":"7.2E-05","AT-3":"1.1E-04","AT-4":"1.3E-04"},{"Metabolite":"Ferulic acid","WC-1":"1.5E-04","WC-2":"N.D.","WC-3":"N.D.","WC-4":"1.1E-04","WT-1":"1.5E-04","WT-2":"N.D.","WT-3":"N.D.","WT-4":"1.5E-04","AC-1":"1.2E-04","AC-2":"6.3E-05","AC-3":"N.D.","AC-4":"2.8E-05","AT-1":"1.4E-04","AT-2":"7.7E-05","AT-3":"9.7E-05","AT-4":"6.5E-05"},{"Metabolite":"Formiminoglutamic acid","WC-1":"3.3E-05","WC-2":"N.D.","WC-3":"2.3E-05","WC-4":"6.1E-05","WT-1":"6.1E-05","WT-2":"N.D.","WT-3":"N.D.","WT-4":"5.2E-05","AC-1":"N.D.","AC-2":"6.3E-05","AC-3":"2.9E-05","AC-4":"N.D.","AT-1":"6.7E-05","AT-2":"N.D.","AT-3":"2.9E-05","AT-4":"N.D."},{"Metabolite":"Formylanthranilic acid","WC-1":"5.9E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"7.1E-05","WT-1":"9.7E-05","WT-2":"N.D.","WT-3":"N.D.","WT-4":"8.3E-05","AC-1":"6.8E-05","AC-2":"N.D.","AC-3":"N.D.","AC-4":"5.5E-05","AT-1":"6.9E-05","AT-2":"8.9E-05","AT-3":"4.8E-05","AT-4":"N.D."},{"Metabolite":"Fructose 6-phosphate","WC-1":"8.4E-05","WC-2":"N.D.","WC-3":"2.5E-04","WC-4":"2.0E-04","WT-1":"2.1E-04","WT-2":"2.4E-04","WT-3":"1.9E-04","WT-4":"5.1E-04","AC-1":"1.4E-04","AC-2":"2.2E-04","AC-3":"2.2E-04","AC-4":"2.6E-04","AT-1":"3.4E-04","AT-2":"2.7E-04","AT-3":"2.9E-04","AT-4":"1.0E-04"},{"Metabolite":"Fumaric acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"2.8E-03","WT-2":"N.D.","WT-3":"3.4E-03","WT-4":"3.3E-03","AC-1":"2.5E-03","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"2.7E-03","AT-2":"N.D.","AT-3":"3.3E-03","AT-4":"N.D."},{"Metabolite":"Galacturonic acid","WC-1":"1.8E-04","WC-2":"4.0E-04","WC-3":"5.0E-04","WC-4":"3.3E-04","WT-1":"4.1E-04","WT-2":"5.4E-04","WT-3":"9.5E-04","WT-4":"6.3E-04","AC-1":"2.0E-04","AC-2":"3.4E-04","AC-3":"4.3E-04","AC-4":"3.6E-04","AT-1":"6.5E-04","AT-2":"3.0E-04","AT-3":"3.7E-04","AT-4":"3.3E-04"},{"Metabolite":"GDP","WC-1":"2.3E-04","WC-2":"4.9E-05","WC-3":"N.D.","WC-4":"N.D.","WT-1":"8.3E-05","WT-2":"1.1E-04","WT-3":"N.D.","WT-4":"4.4E-04","AC-1":"N.D.","AC-2":"1.2E-04","AC-3":"1.7E-04","AC-4":"1.2E-04","AT-1":"1.4E-04","AT-2":"9.3E-05","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Gibberellic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"1.2E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Gln","WC-1":"7.7E-01","WC-2":"6.6E-01","WC-3":"6.7E-01","WC-4":"6.8E-01","WT-1":"7.1E-01","WT-2":"6.4E-01","WT-3":"7.1E-01","WT-4":"6.3E-01","AC-1":"7.6E-01","AC-2":"8.3E-01","AC-3":"7.2E-01","AC-4":"8.7E-01","AT-1":"8.3E-01","AT-2":"9.2E-01","AT-3":"9.5E-01","AT-4":"9.6E-01"},{"Metabolite":"Glu","WC-1":"2.8E-02","WC-2":"5.0E-02","WC-3":"3.9E-02","WC-4":"4.1E-02","WT-1":"7.7E-02","WT-2":"6.9E-02","WT-3":"5.7E-02","WT-4":"6.4E-02","AC-1":"1.0E-01","AC-2":"8.7E-02","AC-3":"7.9E-02","AC-4":"5.4E-02","AT-1":"7.9E-02","AT-2":"6.4E-02","AT-3":"1.1E-01","AT-4":"1.1E-01"},{"Metabolite":"Glucaric acid","WC-1":"6.5E-04","WC-2":"6.7E-04","WC-3":"4.6E-04","WC-4":"7.9E-04","WT-1":"5.1E-04","WT-2":"6.5E-04","WT-3":"8.4E-04","WT-4":"7.3E-04","AC-1":"6.6E-04","AC-2":"6.2E-04","AC-3":"6.2E-04","AC-4":"5.8E-04","AT-1":"8.1E-04","AT-2":"6.6E-04","AT-3":"3.8E-04","AT-4":"4.8E-04"},{"Metabolite":"Gluconic acid","WC-1":"1.2E-02","WC-2":"2.3E-02","WC-3":"3.1E-02","WC-4":"1.2E-02","WT-1":"2.2E-02","WT-2":"3.6E-02","WT-3":"6.8E-02","WT-4":"2.5E-02","AC-1":"1.0E-02","AC-2":"1.5E-02","AC-3":"2.0E-02","AC-4":"1.4E-02","AT-1":"3.4E-02","AT-2":"2.1E-02","AT-3":"2.2E-02","AT-4":"2.0E-02"},{"Metabolite":"Gluconolactone","WC-1":"3.6E-03","WC-2":"6.9E-03","WC-3":"1.1E-02","WC-4":"3.4E-03","WT-1":"6.3E-03","WT-2":"1.1E-02","WT-3":"2.0E-02","WT-4":"7.5E-03","AC-1":"2.8E-03","AC-2":"4.0E-03","AC-3":"5.9E-03","AC-4":"4.1E-03","AT-1":"1.1E-02","AT-2":"6.5E-03","AT-3":"7.2E-03","AT-4":"6.0E-03"},{"Metabolite":"Glucosamine　Galactosamine","WC-1":"4.0E-04","WC-2":"4.1E-04","WC-3":"4.1E-04","WC-4":"5.8E-04","WT-1":"5.1E-04","WT-2":"4.4E-04","WT-3":"4.2E-04","WT-4":"5.3E-04","AC-1":"5.3E-04","AC-2":"5.8E-04","AC-3":"4.5E-04","AC-4":"5.0E-04","AT-1":"5.4E-04","AT-2":"5.1E-04","AT-3":"6.0E-04","AT-4":"4.5E-04"},{"Metabolite":"Glucosaminic acid","WC-1":"2.8E-05","WC-2":"N.D.","WC-3":"1.9E-05","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"4.1E-05","AC-1":"3.1E-05","AC-2":"3.4E-05","AC-3":"3.0E-05","AC-4":"4.0E-05","AT-1":"4.1E-05","AT-2":"3.8E-05","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Glucose 1-phosphate","WC-1":"1.2E-04","WC-2":"3.7E-04","WC-3":"N.D.","WC-4":"2.3E-04","WT-1":"3.6E-04","WT-2":"4.1E-04","WT-3":"5.1E-04","WT-4":"3.9E-04","AC-1":"1.6E-04","AC-2":"2.8E-04","AC-3":"3.0E-04","AC-4":"3.0E-04","AT-1":"4.6E-04","AT-2":"3.0E-04","AT-3":"3.5E-04","AT-4":"2.3E-04"},{"Metabolite":"Glucose 6-phosphate","WC-1":"7.2E-04","WC-2":"1.5E-03","WC-3":"1.8E-03","WC-4":"1.4E-03","WT-1":"1.8E-03","WT-2":"1.8E-03","WT-3":"2.3E-03","WT-4":"3.8E-03","AC-1":"1.1E-03","AC-2":"1.3E-03","AC-3":"1.6E-03","AC-4":"1.6E-03","AT-1":"2.3E-03","AT-2":"1.6E-03","AT-3":"1.5E-03","AT-4":"1.1E-03"},{"Metabolite":"Glucuronic acid","WC-1":"9.8E-04","WC-2":"2.0E-03","WC-3":"2.9E-03","WC-4":"1.1E-03","WT-1":"1.7E-03","WT-2":"2.0E-03","WT-3":"3.6E-03","WT-4":"1.6E-03","AC-1":"1.1E-03","AC-2":"1.4E-03","AC-3":"1.5E-03","AC-4":"1.2E-03","AT-1":"2.6E-03","AT-2":"1.5E-03","AT-3":"1.9E-03","AT-4":"1.7E-03"},{"Metabolite":"Glutathione (GSH)","WC-1":"N.D.","WC-2":"1.9E-04","WC-3":"3.8E-04","WC-4":"N.D.","WT-1":"1.9E-04","WT-2":"3.2E-04","WT-3":"1.7E-04","WT-4":"N.D.","AC-1":"1.5E-05","AC-2":"N.D.","AC-3":"3.2E-05","AC-4":"N.D.","AT-1":"3.3E-05","AT-2":"3.4E-05","AT-3":"4.8E-04","AT-4":"3.4E-04"},{"Metabolite":"Glutathione (GSSG)_divalent","WC-1":"5.2E-02","WC-2":"1.1E-01","WC-3":"2.6E-01","WC-4":"7.8E-02","WT-1":"2.4E-01","WT-2":"2.4E-01","WT-3":"5.1E-01","WT-4":"2.7E-01","AC-1":"2.7E-02","AC-2":"2.0E-02","AC-3":"6.8E-03","AC-4":"7.5E-02","AT-1":"2.9E-01","AT-2":"2.2E-01","AT-3":"2.6E-01","AT-4":"1.7E-01"},{"Metabolite":"Gly","WC-1":"7.4E-02","WC-2":"9.1E-02","WC-3":"6.5E-02","WC-4":"7.7E-02","WT-1":"7.2E-02","WT-2":"7.2E-02","WT-3":"7.0E-02","WT-4":"6.6E-02","AC-1":"1.3E-01","AC-2":"1.3E-01","AC-3":"1.2E-01","AC-4":"9.7E-02","AT-1":"1.2E-01","AT-2":"9.4E-02","AT-3":"9.8E-02","AT-4":"1.1E-01"},{"Metabolite":"Gly-Asp","WC-1":"1.9E-04","WC-2":"1.8E-04","WC-3":"1.9E-04","WC-4":"2.2E-04","WT-1":"2.3E-04","WT-2":"1.9E-04","WT-3":"1.9E-04","WT-4":"2.7E-04","AC-1":"1.8E-04","AC-2":"2.1E-04","AC-3":"1.7E-04","AC-4":"2.0E-04","AT-1":"2.6E-04","AT-2":"2.9E-04","AT-3":"2.7E-04","AT-4":"2.0E-04"},{"Metabolite":"Gly-Gly","WC-1":"1.6E-04","WC-2":"1.0E-04","WC-3":"1.4E-04","WC-4":"1.6E-04","WT-1":"1.2E-04","WT-2":"9.9E-05","WT-3":"1.4E-04","WT-4":"1.7E-04","AC-1":"1.3E-04","AC-2":"1.1E-04","AC-3":"1.0E-04","AC-4":"1.5E-04","AT-1":"1.6E-04","AT-2":"1.7E-04","AT-3":"1.7E-04","AT-4":"1.0E-04"},{"Metabolite":"Glyceric acid","WC-1":"1.6E-03","WC-2":"1.8E-03","WC-3":"1.3E-03","WC-4":"1.8E-03","WT-1":"1.8E-03","WT-2":"1.8E-03","WT-3":"1.9E-03","WT-4":"1.9E-03","AC-1":"1.7E-03","AC-2":"2.0E-03","AC-3":"2.1E-03","AC-4":"1.7E-03","AT-1":"2.4E-03","AT-2":"2.0E-03","AT-3":"1.6E-03","AT-4":"2.0E-03"},{"Metabolite":"Glycerol","WC-1":"2.7E-01","WC-2":"1.4E-01","WC-3":"1.2E-01","WC-4":"2.2E-01","WT-1":"1.4E-01","WT-2":"1.6E-01","WT-3":"1.2E-01","WT-4":"1.2E-01","AC-1":"1.9E-01","AC-2":"1.2E-01","AC-3":"1.9E-01","AC-4":"2.1E-01","AT-1":"2.6E-01","AT-2":"2.3E-01","AT-3":"1.5E-01","AT-4":"2.5E-01"},{"Metabolite":"Glycerol 3-phosphate","WC-1":"2.4E-03","WC-2":"5.4E-03","WC-3":"6.1E-03","WC-4":"3.0E-03","WT-1":"3.8E-03","WT-2":"4.5E-03","WT-3":"7.3E-03","WT-4":"5.0E-03","AC-1":"3.5E-03","AC-2":"5.9E-03","AC-3":"5.6E-03","AC-4":"4.0E-03","AT-1":"6.3E-03","AT-2":"3.8E-03","AT-3":"5.4E-03","AT-4":"3.7E-03"},{"Metabolite":"Glycerophosphocholine","WC-1":"1.4E-01","WC-2":"1.2E-01","WC-3":"1.3E-01","WC-4":"1.2E-01","WT-1":"7.9E-02","WT-2":"9.6E-02","WT-3":"1.0E-01","WT-4":"1.6E-01","AC-1":"8.8E-02","AC-2":"1.1E-01","AC-3":"1.4E-01","AC-4":"1.4E-01","AT-1":"1.4E-01","AT-2":"1.1E-01","AT-3":"1.0E-01","AT-4":"9.8E-02"},{"Metabolite":"Glycocholic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"2.3E-04","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"2.9E-04","AC-2":"1.8E-04","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"1.6E-04","AT-3":"1.9E-04","AT-4":"1.4E-04"},{"Metabolite":"Glycolic acid","WC-1":"5.5E-03","WC-2":"4.7E-03","WC-3":"3.8E-03","WC-4":"4.6E-03","WT-1":"5.0E-03","WT-2":"5.2E-03","WT-3":"6.6E-03","WT-4":"4.6E-03","AC-1":"4.2E-03","AC-2":"4.9E-03","AC-3":"5.4E-03","AC-4":"4.4E-03","AT-1":"5.1E-03","AT-2":"4.7E-03","AT-3":"4.5E-03","AT-4":"5.6E-03"},{"Metabolite":"Glyoxylic acid","WC-1":"4.6E-04","WC-2":"3.3E-04","WC-3":"N.D.","WC-4":"N.D.","WT-1":"4.0E-04","WT-2":"3.5E-04","WT-3":"4.1E-04","WT-4":"5.0E-04","AC-1":"4.3E-04","AC-2":"3.6E-04","AC-3":"2.7E-04","AC-4":"N.D.","AT-1":"4.7E-04","AT-2":"3.5E-04","AT-3":"3.0E-04","AT-4":"4.4E-04"},{"Metabolite":"GMP","WC-1":"9.2E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"6.0E-05","WT-1":"4.9E-05","WT-2":"5.3E-05","WT-3":"N.D.","WT-4":"5.3E-04","AC-1":"5.6E-05","AC-2":"9.5E-05","AC-3":"1.0E-04","AC-4":"7.1E-05","AT-1":"8.3E-05","AT-2":"6.7E-05","AT-3":"5.0E-05","AT-4":"5.4E-05"},{"Metabolite":"GTP","WC-1":"3.0E-04","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"9.8E-05","WT-2":"1.1E-04","WT-3":"N.D.","WT-4":"4.0E-04","AC-1":"7.1E-05","AC-2":"1.1E-04","AC-3":"2.5E-04","AC-4":"1.2E-04","AT-1":"4.5E-05","AT-2":"1.4E-04","AT-3":"8.1E-05","AT-4":"N.D."},{"Metabolite":"Guanidinosuccinic acid","WC-1":"7.5E-04","WC-2":"7.4E-04","WC-3":"1.2E-03","WC-4":"1.1E-03","WT-1":"5.3E-04","WT-2":"5.3E-04","WT-3":"8.2E-04","WT-4":"1.2E-03","AC-1":"7.8E-04","AC-2":"8.6E-04","AC-3":"1.4E-04","AC-4":"1.5E-03","AT-1":"1.5E-03","AT-2":"8.2E-04","AT-3":"6.3E-04","AT-4":"3.9E-04"},{"Metabolite":"Guanidoacetic acid","WC-1":"4.4E-03","WC-2":"5.1E-03","WC-3":"4.0E-03","WC-4":"5.4E-03","WT-1":"7.3E-03","WT-2":"5.8E-03","WT-3":"4.3E-03","WT-4":"6.0E-03","AC-1":"1.2E-02","AC-2":"1.1E-02","AC-3":"7.2E-03","AC-4":"7.7E-03","AT-1":"6.1E-03","AT-2":"7.2E-03","AT-3":"6.2E-03","AT-4":"6.9E-03"},{"Metabolite":"Guanine","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"8.1E-06","WT-3":"N.D.","WT-4":"1.2E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"3.6E-05","AT-4":"N.D."},{"Metabolite":"Hexamine","WC-1":"5.0E-06","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"1.1E-05","AT-1":"N.D.","AT-2":"N.D.","AT-3":"2.5E-05","AT-4":"N.D."},{"Metabolite":"Hippuric acid","WC-1":"2.9E-03","WC-2":"1.1E-03","WC-3":"2.2E-03","WC-4":"2.7E-03","WT-1":"4.4E-03","WT-2":"2.4E-03","WT-3":"3.8E-03","WT-4":"6.1E-03","AC-1":"2.3E-03","AC-2":"1.6E-03","AC-3":"9.2E-04","AC-4":"2.4E-03","AT-1":"4.8E-03","AT-2":"3.1E-03","AT-3":"3.0E-03","AT-4":"3.0E-03"},{"Metabolite":"His","WC-1":"1.6E-01","WC-2":"1.7E-01","WC-3":"1.5E-01","WC-4":"1.5E-01","WT-1":"1.8E-01","WT-2":"1.5E-01","WT-3":"1.5E-01","WT-4":"2.0E-01","AC-1":"2.5E-01","AC-2":"2.1E-01","AC-3":"1.8E-01","AC-4":"2.0E-01","AT-1":"1.9E-01","AT-2":"2.1E-01","AT-3":"2.3E-01","AT-4":"2.3E-01"},{"Metabolite":"His-Glu","WC-1":"N.D.","WC-2":"4.6E-06","WC-3":"N.D.","WC-4":"N.D.","WT-1":"7.9E-06","WT-2":"N.D.","WT-3":"5.7E-06","WT-4":"N.D.","AC-1":"5.9E-06","AC-2":"5.5E-06","AC-3":"1.1E-05","AC-4":"N.D.","AT-1":"6.5E-06","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Histamine","WC-1":"1.0E-04","WC-2":"1.4E-04","WC-3":"8.0E-05","WC-4":"1.3E-04","WT-1":"9.6E-05","WT-2":"6.7E-05","WT-3":"3.2E-05","WT-4":"1.9E-04","AC-1":"1.0E-04","AC-2":"1.0E-04","AC-3":"2.1E-04","AC-4":"1.1E-04","AT-1":"7.9E-05","AT-2":"6.2E-05","AT-3":"9.2E-05","AT-4":"7.1E-05"},{"Metabolite":"Homoarginine","WC-1":"1.1E-03","WC-2":"4.3E-04","WC-3":"4.7E-04","WC-4":"1.2E-03","WT-1":"7.0E-04","WT-2":"4.9E-04","WT-3":"5.4E-04","WT-4":"1.1E-03","AC-1":"7.1E-04","AC-2":"7.9E-04","AC-3":"8.7E-04","AC-4":"1.1E-03","AT-1":"5.9E-04","AT-2":"9.1E-04","AT-3":"4.9E-04","AT-4":"5.0E-04"},{"Metabolite":"Homocarnosine","WC-1":"2.9E-04","WC-2":"1.0E-03","WC-3":"6.3E-04","WC-4":"3.0E-04","WT-1":"5.5E-04","WT-2":"9.6E-04","WT-3":"7.1E-04","WT-4":"4.1E-04","AC-1":"4.5E-04","AC-2":"8.6E-04","AC-3":"1.8E-03","AC-4":"4.5E-04","AT-1":"7.9E-04","AT-2":"5.5E-04","AT-3":"1.1E-03","AT-4":"1.1E-03"},{"Metabolite":"Homocitrulline","WC-1":"1.8E-03","WC-2":"1.9E-03","WC-3":"1.4E-03","WC-4":"1.6E-03","WT-1":"1.3E-03","WT-2":"1.4E-03","WT-3":"1.5E-03","WT-4":"1.7E-03","AC-1":"2.1E-03","AC-2":"2.8E-03","AC-3":"2.6E-03","AC-4":"2.8E-03","AT-1":"2.8E-03","AT-2":"2.3E-03","AT-3":"2.4E-03","AT-4":"2.1E-03"},{"Metabolite":"Homocystine","WC-1":"1.8E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"1.3E-05","WT-1":"6.4E-06","WT-2":"N.D.","WT-3":"1.0E-05","WT-4":"1.9E-05","AC-1":"N.D.","AC-2":"1.2E-05","AC-3":"8.6E-06","AC-4":"9.2E-06","AT-1":"1.2E-05","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Homoserine","WC-1":"9.2E-04","WC-2":"1.1E-03","WC-3":"8.3E-04","WC-4":"9.1E-04","WT-1":"1.1E-03","WT-2":"9.6E-04","WT-3":"1.1E-03","WT-4":"1.2E-03","AC-1":"1.1E-03","AC-2":"1.3E-03","AC-3":"1.1E-03","AC-4":"1.1E-03","AT-1":"1.2E-03","AT-2":"1.1E-03","AT-3":"1.1E-03","AT-4":"1.0E-03"},{"Metabolite":"Homoserinelactone","WC-1":"N.D.","WC-2":"1.5E-04","WC-3":"2.1E-04","WC-4":"8.6E-05","WT-1":"N.D.","WT-2":"1.3E-04","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Homovanillic acid　3,4-Dihydroxyhydrocinnamic acid　Hydroxyphenyllactic acid","WC-1":"1.2E-03","WC-2":"1.2E-03","WC-3":"1.8E-03","WC-4":"1.6E-03","WT-1":"2.0E-03","WT-2":"1.6E-03","WT-3":"2.7E-03","WT-4":"2.5E-03","AC-1":"1.3E-03","AC-2":"1.0E-03","AC-3":"4.7E-04","AC-4":"1.2E-03","AT-1":"2.1E-03","AT-2":"2.4E-03","AT-3":"1.8E-03","AT-4":"1.5E-03"},{"Metabolite":"Hydroxyindole","WC-1":"2.7E-04","WC-2":"2.2E-04","WC-3":"3.8E-05","WC-4":"1.9E-04","WT-1":"7.1E-04","WT-2":"4.1E-04","WT-3":"3.4E-04","WT-4":"2.1E-04","AC-1":"5.3E-04","AC-2":"3.8E-04","AC-3":"2.2E-04","AC-4":"1.1E-04","AT-1":"3.2E-04","AT-2":"6.1E-04","AT-3":"4.9E-04","AT-4":"7.6E-04"},{"Metabolite":"Hydroxyproline","WC-1":"2.1E-02","WC-2":"4.1E-02","WC-3":"3.0E-02","WC-4":"2.0E-02","WT-1":"2.4E-02","WT-2":"2.9E-02","WT-3":"2.5E-02","WT-4":"2.1E-02","AC-1":"2.1E-02","AC-2":"3.9E-02","AC-3":"5.5E-02","AC-4":"2.1E-02","AT-1":"2.9E-02","AT-2":"2.4E-02","AT-3":"2.9E-02","AT-4":"3.2E-02"},{"Metabolite":"Hypotaurine","WC-1":"1.8E-03","WC-2":"3.3E-03","WC-3":"2.6E-03","WC-4":"2.3E-03","WT-1":"1.2E-02","WT-2":"8.9E-03","WT-3":"9.1E-03","WT-4":"4.8E-03","AC-1":"5.0E-03","AC-2":"3.5E-03","AC-3":"1.5E-03","AC-4":"1.4E-03","AT-1":"5.5E-03","AT-2":"6.3E-03","AT-3":"7.9E-03","AT-4":"8.5E-03"},{"Metabolite":"Hypoxanthine","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"2.9E-05"},{"Metabolite":"Ile","WC-1":"3.5E-01","WC-2":"3.3E-01","WC-3":"3.3E-01","WC-4":"3.7E-01","WT-1":"3.3E-01","WT-2":"2.7E-01","WT-3":"3.5E-01","WT-4":"4.0E-01","AC-1":"4.1E-01","AC-2":"3.9E-01","AC-3":"3.3E-01","AC-4":"4.2E-01","AT-1":"4.5E-01","AT-2":"3.7E-01","AT-3":"4.4E-01","AT-4":"3.7E-01"},{"Metabolite":"Imidazole-4-acetic acid","WC-1":"1.3E-04","WC-2":"1.9E-04","WC-3":"1.6E-04","WC-4":"1.5E-04","WT-1":"2.0E-04","WT-2":"1.8E-04","WT-3":"2.0E-04","WT-4":"1.9E-04","AC-1":"2.1E-04","AC-2":"1.7E-04","AC-3":"2.0E-04","AC-4":"1.4E-04","AT-1":"2.6E-04","AT-2":"2.2E-04","AT-3":"2.5E-04","AT-4":"2.2E-04"},{"Metabolite":"Imidazolelactic acid","WC-1":"1.3E-04","WC-2":"8.6E-04","WC-3":"1.0E-03","WC-4":"1.4E-04","WT-1":"4.0E-04","WT-2":"5.7E-04","WT-3":"8.3E-04","WT-4":"2.5E-04","AC-1":"1.8E-04","AC-2":"2.6E-04","AC-3":"4.2E-04","AC-4":"1.5E-04","AT-1":"9.4E-04","AT-2":"5.0E-04","AT-3":"8.3E-04","AT-4":"7.9E-04"},{"Metabolite":"IMP","WC-1":"N.D.","WC-2":"1.3E-04","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"6.2E-05","WT-3":"N.D.","WT-4":"N.D.","AC-1":"9.9E-05","AC-2":"7.7E-05","AC-3":"1.6E-04","AC-4":"N.D.","AT-1":"1.2E-04","AT-2":"N.D.","AT-3":"N.D.","AT-4":"1.0E-04"},{"Metabolite":"Indole-3-acetic acid","WC-1":"1.3E-04","WC-2":"4.4E-05","WC-3":"N.D.","WC-4":"6.6E-05","WT-1":"1.4E-04","WT-2":"7.6E-05","WT-3":"8.1E-05","WT-4":"2.1E-04","AC-1":"1.7E-04","AC-2":"1.4E-04","AC-3":"7.4E-05","AC-4":"9.9E-05","AT-1":"8.7E-05","AT-2":"1.2E-04","AT-3":"1.7E-04","AT-4":"1.3E-04"},{"Metabolite":"Indole-3-carboxylic acid","WC-1":"7.3E-05","WC-2":"4.2E-05","WC-3":"N.D.","WC-4":"8.9E-05","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"1.1E-04","AC-1":"1.3E-04","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"1.1E-04","AT-2":"8.2E-05","AT-3":"6.4E-05","AT-4":"7.9E-05"},{"Metabolite":"Indole-3-propionic acid","WC-1":"3.2E-04","WC-2":"3.8E-04","WC-3":"6.0E-04","WC-4":"3.1E-04","WT-1":"7.7E-04","WT-2":"5.4E-04","WT-3":"7.9E-04","WT-4":"6.6E-04","AC-1":"3.2E-04","AC-2":"6.0E-04","AC-3":"3.7E-04","AC-4":"4.7E-04","AT-1":"7.9E-04","AT-2":"5.9E-04","AT-3":"4.8E-04","AT-4":"7.3E-04"},{"Metabolite":"Inosine","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"1.8E-05","WT-1":"N.D.","WT-2":"N.D.","WT-3":"2.7E-05","WT-4":"1.9E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"4.5E-05","AT-2":"N.D.","AT-3":"6.0E-05","AT-4":"7.0E-05"},{"Metabolite":"Isatin","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"8.0E-04","WT-2":"N.D.","WT-3":"7.3E-04","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Isethionic acid","WC-1":"4.4E-03","WC-2":"5.7E-03","WC-3":"6.0E-03","WC-4":"4.0E-03","WT-1":"3.7E-03","WT-2":"5.0E-03","WT-3":"3.8E-03","WT-4":"5.7E-03","AC-1":"7.8E-03","AC-2":"6.8E-03","AC-3":"4.3E-03","AC-4":"8.0E-03","AT-1":"7.3E-03","AT-2":"6.9E-03","AT-3":"6.3E-03","AT-4":"5.6E-03"},{"Metabolite":"Isobutyrylcarnitine","WC-1":"3.8E-03","WC-2":"1.2E-03","WC-3":"2.2E-03","WC-4":"2.6E-03","WT-1":"4.8E-03","WT-2":"3.0E-03","WT-3":"8.0E-03","WT-4":"4.2E-03","AC-1":"1.5E-03","AC-2":"1.2E-03","AC-3":"7.3E-04","AC-4":"2.4E-03","AT-1":"5.1E-03","AT-2":"4.0E-03","AT-3":"3.1E-03","AT-4":"2.5E-03"},{"Metabolite":"Isocitric acid","WC-1":"1.1E-02","WC-2":"1.1E-02","WC-3":"1.2E-02","WC-4":"1.3E-02","WT-1":"1.4E-02","WT-2":"1.5E-02","WT-3":"1.4E-02","WT-4":"2.5E-02","AC-1":"1.1E-02","AC-2":"1.5E-02","AC-3":"1.3E-02","AC-4":"1.3E-02","AT-1":"2.0E-02","AT-2":"1.9E-02","AT-3":"1.7E-02","AT-4":"1.5E-02"},{"Metabolite":"Isoglutamic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"1.2E-04","WT-1":"N.D.","WT-2":"8.8E-05","WT-3":"N.D.","WT-4":"2.2E-04","AC-1":"2.0E-04","AC-2":"1.8E-04","AC-3":"N.D.","AC-4":"1.4E-04","AT-1":"N.D.","AT-2":"9.5E-05","AT-3":"9.1E-05","AT-4":"N.D."},{"Metabolite":"Isovaleric acid　Valeric acid　DL-2-Methylbutyric acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"1.0E-03","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Isovalerylalanine","WC-1":"7.2E-04","WC-2":"5.4E-04","WC-3":"9.8E-04","WC-4":"7.9E-04","WT-1":"7.6E-04","WT-2":"7.4E-04","WT-3":"7.3E-04","WT-4":"1.3E-03","AC-1":"8.9E-04","AC-2":"6.8E-04","AC-3":"3.5E-04","AC-4":"6.4E-04","AT-1":"1.1E-03","AT-2":"7.3E-04","AT-3":"1.1E-03","AT-4":"7.9E-04"},{"Metabolite":"Isovalerylcarnitine","WC-1":"1.0E-03","WC-2":"5.5E-04","WC-3":"5.0E-04","WC-4":"9.4E-04","WT-1":"1.6E-03","WT-2":"1.0E-03","WT-3":"1.7E-03","WT-4":"2.4E-03","AC-1":"9.0E-04","AC-2":"7.7E-04","AC-3":"6.5E-04","AC-4":"1.1E-03","AT-1":"1.3E-03","AT-2":"1.3E-03","AT-3":"1.2E-03","AT-4":"1.4E-03"},{"Metabolite":"Kynurenic acid","WC-1":"5.7E-05","WC-2":"N.D.","WC-3":"3.9E-05","WC-4":"5.4E-05","WT-1":"1.0E-04","WT-2":"N.D.","WT-3":"1.3E-04","WT-4":"1.7E-04","AC-1":"7.7E-05","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"1.2E-04","AT-2":"8.9E-05","AT-3":"8.8E-05","AT-4":"9.8E-05"},{"Metabolite":"Kynurenine","WC-1":"6.6E-03","WC-2":"2.1E-03","WC-3":"1.7E-03","WC-4":"4.5E-03","WT-1":"3.5E-03","WT-2":"2.6E-03","WT-3":"2.4E-03","WT-4":"5.1E-03","AC-1":"3.9E-03","AC-2":"3.6E-03","AC-3":"1.7E-03","AC-4":"4.7E-03","AT-1":"4.3E-03","AT-2":"4.4E-03","AT-3":"3.3E-03","AT-4":"3.3E-03"},{"Metabolite":"Lactic acid","WC-1":"8.8E-01","WC-2":"9.4E-01","WC-3":"1.2E+00","WC-4":"9.5E-01","WT-1":"1.1E+00","WT-2":"1.0E+00","WT-3":"1.6E+00","WT-4":"1.2E+00","AC-1":"7.9E-01","AC-2":"7.7E-01","AC-3":"7.0E-01","AC-4":"7.5E-01","AT-1":"1.2E+00","AT-2":"1.0E+00","AT-3":"1.1E+00","AT-4":"9.3E-01"},{"Metabolite":"Lauric acid","WC-1":"4.1E-03","WC-2":"4.9E-03","WC-3":"4.9E-03","WC-4":"4.0E-03","WT-1":"4.5E-03","WT-2":"4.9E-03","WT-3":"6.2E-03","WT-4":"3.8E-03","AC-1":"5.1E-03","AC-2":"5.2E-03","AC-3":"5.3E-03","AC-4":"4.2E-03","AT-1":"5.5E-03","AT-2":"4.7E-03","AT-3":"3.7E-03","AT-4":"4.9E-03"},{"Metabolite":"Lauroylcarnitine","WC-1":"1.3E-04","WC-2":"7.3E-05","WC-3":"8.2E-05","WC-4":"7.1E-05","WT-1":"8.1E-05","WT-2":"9.1E-05","WT-3":"8.4E-05","WT-4":"1.2E-04","AC-1":"6.7E-05","AC-2":"3.2E-05","AC-3":"3.3E-05","AC-4":"9.8E-05","AT-1":"4.0E-05","AT-2":"1.3E-04","AT-3":"8.8E-05","AT-4":"7.2E-05"},{"Metabolite":"Leu","WC-1":"6.4E-01","WC-2":"6.4E-01","WC-3":"6.1E-01","WC-4":"6.6E-01","WT-1":"5.8E-01","WT-2":"4.7E-01","WT-3":"6.5E-01","WT-4":"7.1E-01","AC-1":"6.2E-01","AC-2":"7.3E-01","AC-3":"5.9E-01","AC-4":"7.3E-01","AT-1":"7.9E-01","AT-2":"6.4E-01","AT-3":"8.1E-01","AT-4":"6.4E-01"},{"Metabolite":"Lipoamide","WC-1":"1.1E-04","WC-2":"4.8E-05","WC-3":"3.6E-05","WC-4":"2.0E-04","WT-1":"3.7E-05","WT-2":"4.8E-05","WT-3":"2.3E-05","WT-4":"1.1E-04","AC-1":"1.5E-04","AC-2":"2.4E-04","AC-3":"1.1E-04","AC-4":"8.9E-05","AT-1":"2.5E-05","AT-2":"2.2E-05","AT-3":"4.3E-05","AT-4":"N.D."},{"Metabolite":"Lys","WC-1":"4.0E-01","WC-2":"3.4E-01","WC-3":"2.7E-01","WC-4":"4.4E-01","WT-1":"2.8E-01","WT-2":"2.3E-01","WT-3":"2.9E-01","WT-4":"3.6E-01","AC-1":"3.5E-01","AC-2":"5.1E-01","AC-3":"5.2E-01","AC-4":"4.6E-01","AT-1":"4.3E-01","AT-2":"3.9E-01","AT-3":"3.7E-01","AT-4":"3.4E-01"},{"Metabolite":"Malic acid","WC-1":"4.3E-02","WC-2":"3.8E-02","WC-3":"5.2E-02","WC-4":"4.9E-02","WT-1":"7.6E-02","WT-2":"6.2E-02","WT-3":"8.7E-02","WT-4":"9.4E-02","AC-1":"6.4E-02","AC-2":"5.2E-02","AC-3":"2.2E-02","AC-4":"2.7E-02","AT-1":"7.5E-02","AT-2":"7.5E-02","AT-3":"1.0E-01","AT-4":"7.2E-02"},{"Metabolite":"Malonylcarnitine","WC-1":"3.9E-05","WC-2":"N.D.","WC-3":"2.8E-05","WC-4":"7.7E-06","WT-1":"1.1E-05","WT-2":"5.1E-05","WT-3":"2.9E-05","WT-4":"3.8E-05","AC-1":"3.5E-05","AC-2":"6.9E-05","AC-3":"N.D.","AC-4":"2.5E-05","AT-1":"1.3E-05","AT-2":"3.4E-05","AT-3":"4.6E-05","AT-4":"3.5E-05"},{"Metabolite":"Mannosamine","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"8.2E-05","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"4.2E-05","AC-2":"9.9E-05","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Met","WC-1":"1.8E-01","WC-2":"2.0E-01","WC-3":"1.1E-01","WC-4":"2.1E-01","WT-1":"1.7E-01","WT-2":"1.3E-01","WT-3":"1.4E-01","WT-4":"2.0E-01","AC-1":"1.9E-01","AC-2":"2.2E-01","AC-3":"2.3E-01","AC-4":"2.0E-01","AT-1":"2.2E-01","AT-2":"1.7E-01","AT-3":"1.5E-01","AT-4":"1.6E-01"},{"Metabolite":"Metanephrine","WC-1":"1.8E-05","WC-2":"9.1E-06","WC-3":"1.7E-05","WC-4":"1.4E-05","WT-1":"1.4E-05","WT-2":"1.5E-05","WT-3":"3.0E-05","WT-4":"3.9E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"8.0E-06","AC-4":"1.8E-05","AT-1":"N.D.","AT-2":"1.1E-05","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Methionine sulfoxide","WC-1":"1.3E-02","WC-2":"1.0E-02","WC-3":"5.9E-03","WC-4":"1.6E-02","WT-1":"9.9E-03","WT-2":"7.7E-03","WT-3":"1.1E-02","WT-4":"1.3E-02","AC-1":"1.1E-02","AC-2":"1.8E-02","AC-3":"1.4E-02","AC-4":"9.4E-03","AT-1":"1.4E-02","AT-2":"1.1E-02","AT-3":"1.3E-02","AT-4":"1.0E-02"},{"Metabolite":"Methyl sulfate","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"4.9E-04","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Methylguanidine","WC-1":"2.0E-05","WC-2":"N.D.","WC-3":"9.1E-06","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"2.3E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"2.8E-05","AT-2":"2.7E-05","AT-3":"3.0E-05","AT-4":"N.D."},{"Metabolite":"Mevalonic acid","WC-1":"1.3E-04","WC-2":"1.2E-04","WC-3":"1.4E-04","WC-4":"1.4E-04","WT-1":"1.5E-04","WT-2":"1.5E-04","WT-3":"9.9E-05","WT-4":"2.1E-04","AC-1":"1.7E-04","AC-2":"1.9E-04","AC-3":"1.6E-04","AC-4":"1.3E-04","AT-1":"2.3E-04","AT-2":"1.6E-04","AT-3":"1.8E-04","AT-4":"2.4E-04"},{"Metabolite":"Mucic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"2.6E-05","WT-1":"N.D.","WT-2":"N.D.","WT-3":"4.0E-05","WT-4":"6.6E-05","AC-1":"N.D.","AC-2":"8.0E-05","AC-3":"4.1E-05","AC-4":"8.7E-05","AT-1":"1.2E-04","AT-2":"1.0E-04","AT-3":"4.4E-05","AT-4":"7.0E-05"},{"Metabolite":"Muscimol","WC-1":"2.4E-04","WC-2":"2.4E-04","WC-3":"1.5E-04","WC-4":"2.2E-04","WT-1":"2.0E-04","WT-2":"2.3E-04","WT-3":"2.4E-04","WT-4":"2.9E-04","AC-1":"2.8E-04","AC-2":"2.3E-04","AC-3":"2.5E-04","AC-4":"2.2E-04","AT-1":"2.2E-04","AT-2":"2.5E-04","AT-3":"2.5E-04","AT-4":"2.6E-04"},{"Metabolite":"myo-Inositol 1-phosphate　myo-Inositol 3-phosphate","WC-1":"1.4E-04","WC-2":"1.8E-04","WC-3":"1.1E-04","WC-4":"1.5E-04","WT-1":"4.9E-05","WT-2":"9.8E-05","WT-3":"N.D.","WT-4":"1.5E-04","AC-1":"1.4E-04","AC-2":"1.9E-04","AC-3":"2.6E-04","AC-4":"1.5E-04","AT-1":"1.1E-04","AT-2":"8.6E-05","AT-3":"1.3E-04","AT-4":"1.3E-04"},{"Metabolite":"Myristoleic acid","WC-1":"2.2E-04","WC-2":"2.7E-04","WC-3":"4.9E-04","WC-4":"1.4E-04","WT-1":"3.1E-04","WT-2":"4.3E-04","WT-3":"3.0E-04","WT-4":"3.1E-04","AC-1":"1.9E-04","AC-2":"5.0E-04","AC-3":"2.1E-04","AC-4":"4.7E-04","AT-1":"2.5E-04","AT-2":"6.0E-04","AT-3":"3.9E-04","AT-4":"4.4E-04"},{"Metabolite":"N,N-Dimethylglycine","WC-1":"1.9E-02","WC-2":"1.5E-02","WC-3":"1.7E-02","WC-4":"2.3E-02","WT-1":"1.8E-02","WT-2":"1.4E-02","WT-3":"1.5E-02","WT-4":"2.6E-02","AC-1":"1.8E-02","AC-2":"1.8E-02","AC-3":"1.6E-02","AC-4":"2.6E-02","AT-1":"1.9E-02","AT-2":"2.0E-02","AT-3":"2.1E-02","AT-4":"1.9E-02"},{"Metabolite":"N-(1-Deoxy-1-fructosyl)valine","WC-1":"1.6E-03","WC-2":"1.5E-03","WC-3":"1.3E-03","WC-4":"1.7E-03","WT-1":"1.5E-03","WT-2":"1.4E-03","WT-3":"1.4E-03","WT-4":"3.6E-03","AC-1":"1.2E-03","AC-2":"2.2E-03","AC-3":"2.1E-03","AC-4":"2.0E-03","AT-1":"2.7E-03","AT-2":"2.3E-03","AT-3":"3.6E-03","AT-4":"2.2E-03"},{"Metabolite":"N-Acetyl-β-alanine","WC-1":"2.1E-04","WC-2":"2.1E-04","WC-3":"2.0E-04","WC-4":"3.0E-04","WT-1":"2.7E-04","WT-2":"2.5E-04","WT-3":"3.1E-04","WT-4":"3.1E-04","AC-1":"2.6E-04","AC-2":"1.9E-04","AC-3":"2.3E-04","AC-4":"1.8E-04","AT-1":"4.1E-04","AT-2":"2.8E-04","AT-3":"2.6E-04","AT-4":"1.9E-04"},{"Metabolite":"N-Acetylalanine","WC-1":"4.4E-04","WC-2":"4.5E-04","WC-3":"5.9E-04","WC-4":"4.1E-04","WT-1":"4.4E-04","WT-2":"4.2E-04","WT-3":"4.3E-04","WT-4":"4.9E-04","AC-1":"4.3E-04","AC-2":"4.8E-04","AC-3":"3.8E-04","AC-4":"5.2E-04","AT-1":"5.9E-04","AT-2":"5.3E-04","AT-3":"4.5E-04","AT-4":"4.2E-04"},{"Metabolite":"N-Acetylasparagine","WC-1":"1.4E-04","WC-2":"1.5E-04","WC-3":"1.7E-04","WC-4":"1.5E-04","WT-1":"2.0E-04","WT-2":"1.6E-04","WT-3":"2.7E-04","WT-4":"1.9E-04","AC-1":"1.6E-04","AC-2":"1.9E-04","AC-3":"1.5E-04","AC-4":"1.2E-04","AT-1":"3.2E-04","AT-2":"2.2E-04","AT-3":"2.1E-04","AT-4":"2.1E-04"},{"Metabolite":"N-Acetylaspartic acid","WC-1":"3.5E-04","WC-2":"3.1E-04","WC-3":"3.5E-04","WC-4":"2.9E-04","WT-1":"4.0E-04","WT-2":"3.2E-04","WT-3":"3.8E-04","WT-4":"4.7E-04","AC-1":"2.6E-04","AC-2":"3.3E-04","AC-3":"2.8E-04","AC-4":"1.8E-04","AT-1":"3.6E-04","AT-2":"3.3E-04","AT-3":"2.9E-04","AT-4":"2.9E-04"},{"Metabolite":"N-Acetylglucosamine 1-phosphate","WC-1":"2.0E-05","WC-2":"2.1E-04","WC-3":"1.7E-04","WC-4":"9.6E-05","WT-1":"2.1E-04","WT-2":"2.1E-04","WT-3":"9.6E-05","WT-4":"2.4E-04","AC-1":"1.1E-04","AC-2":"2.3E-04","AC-3":"3.2E-04","AC-4":"2.1E-04","AT-1":"2.3E-04","AT-2":"1.2E-04","AT-3":"1.5E-04","AT-4":"1.4E-04"},{"Metabolite":"N-Acetylglucosamine　N-Acetylmannosamine　N-Acetylgalactosamine","WC-1":"1.4E-03","WC-2":"1.6E-03","WC-3":"2.2E-03","WC-4":"1.4E-03","WT-1":"1.3E-03","WT-2":"1.6E-03","WT-3":"1.7E-03","WT-4":"1.5E-03","AC-1":"1.5E-03","AC-2":"1.2E-03","AC-3":"1.7E-03","AC-4":"1.5E-03","AT-1":"1.9E-03","AT-2":"1.7E-03","AT-3":"1.6E-03","AT-4":"1.6E-03"},{"Metabolite":"N-Acetylglucosylamine","WC-1":"2.5E-05","WC-2":"2.4E-05","WC-3":"3.4E-05","WC-4":"2.6E-05","WT-1":"3.0E-05","WT-2":"2.9E-05","WT-3":"4.0E-05","WT-4":"4.7E-05","AC-1":"N.D.","AC-2":"2.5E-05","AC-3":"2.5E-05","AC-4":"3.0E-05","AT-1":"3.2E-05","AT-2":"3.0E-05","AT-3":"3.7E-05","AT-4":"2.0E-05"},{"Metabolite":"N-Acetylglutamic acid","WC-1":"3.7E-04","WC-2":"4.1E-04","WC-3":"5.5E-04","WC-4":"5.8E-04","WT-1":"6.5E-04","WT-2":"5.2E-04","WT-3":"7.0E-04","WT-4":"8.2E-04","AC-1":"3.8E-04","AC-2":"3.9E-04","AC-3":"3.6E-04","AC-4":"2.3E-04","AT-1":"6.7E-04","AT-2":"4.1E-04","AT-3":"4.7E-04","AT-4":"4.0E-04"},{"Metabolite":"N-Acetylglutamine","WC-1":"2.4E-04","WC-2":"6.0E-04","WC-3":"1.3E-03","WC-4":"2.4E-04","WT-1":"5.8E-04","WT-2":"4.1E-04","WT-3":"8.9E-04","WT-4":"2.7E-04","AC-1":"2.5E-04","AC-2":"N.D.","AC-3":"3.9E-04","AC-4":"2.8E-04","AT-1":"7.5E-04","AT-2":"5.3E-04","AT-3":"7.5E-04","AT-4":"6.0E-04"},{"Metabolite":"N-Acetylglycine","WC-1":"1.4E-03","WC-2":"1.1E-03","WC-3":"2.3E-03","WC-4":"8.9E-04","WT-1":"8.1E-04","WT-2":"1.5E-03","WT-3":"1.6E-03","WT-4":"1.0E-03","AC-1":"1.4E-03","AC-2":"1.2E-03","AC-3":"1.0E-03","AC-4":"1.1E-03","AT-1":"1.3E-03","AT-2":"1.4E-03","AT-3":"1.2E-03","AT-4":"1.6E-03"},{"Metabolite":"N-Acetylhistidine","WC-1":"1.4E-03","WC-2":"1.6E-03","WC-3":"2.3E-03","WC-4":"1.5E-03","WT-1":"1.5E-03","WT-2":"1.3E-03","WT-3":"1.7E-03","WT-4":"2.2E-03","AC-1":"1.3E-03","AC-2":"1.2E-03","AC-3":"1.1E-03","AC-4":"1.9E-03","AT-1":"2.0E-03","AT-2":"1.7E-03","AT-3":"2.0E-03","AT-4":"1.5E-03"},{"Metabolite":"N-Acetylleucine","WC-1":"N.D.","WC-2":"9.0E-04","WC-3":"2.6E-03","WC-4":"5.4E-04","WT-1":"1.5E-03","WT-2":"1.6E-03","WT-3":"5.5E-03","WT-4":"9.4E-04","AC-1":"4.0E-04","AC-2":"2.5E-04","AC-3":"2.2E-04","AC-4":"5.5E-04","AT-1":"2.9E-03","AT-2":"1.4E-03","AT-3":"1.5E-03","AT-4":"1.0E-03"},{"Metabolite":"N-Acetyllysine","WC-1":"6.1E-04","WC-2":"9.6E-04","WC-3":"1.0E-03","WC-4":"6.5E-04","WT-1":"1.0E-03","WT-2":"9.4E-04","WT-3":"1.3E-03","WT-4":"1.2E-03","AC-1":"6.6E-04","AC-2":"9.0E-04","AC-3":"7.1E-04","AC-4":"7.1E-04","AT-1":"1.4E-03","AT-2":"1.2E-03","AT-3":"1.1E-03","AT-4":"9.8E-04"},{"Metabolite":"N-Acetylmethionine","WC-1":"3.3E-04","WC-2":"2.5E-04","WC-3":"4.7E-04","WC-4":"3.1E-04","WT-1":"3.5E-04","WT-2":"2.8E-04","WT-3":"5.3E-04","WT-4":"4.0E-04","AC-1":"3.0E-04","AC-2":"2.0E-04","AC-3":"1.4E-04","AC-4":"2.1E-04","AT-1":"3.7E-04","AT-2":"3.0E-04","AT-3":"4.0E-04","AT-4":"3.0E-04"},{"Metabolite":"N-Acetylmuramic acid","WC-1":"N.D.","WC-2":"9.0E-05","WC-3":"8.5E-05","WC-4":"5.5E-05","WT-1":"7.8E-05","WT-2":"N.D.","WT-3":"6.6E-05","WT-4":"5.3E-05","AC-1":"N.D.","AC-2":"8.0E-05","AC-3":"1.5E-04","AC-4":"N.D.","AT-1":"9.8E-05","AT-2":"N.D.","AT-3":"9.8E-05","AT-4":"9.8E-05"},{"Metabolite":"N-Acetylneuraminic acid","WC-1":"2.5E-04","WC-2":"2.6E-04","WC-3":"3.6E-04","WC-4":"2.6E-04","WT-1":"2.4E-04","WT-2":"2.3E-04","WT-3":"2.6E-04","WT-4":"2.6E-04","AC-1":"1.9E-04","AC-2":"3.1E-04","AC-3":"2.8E-04","AC-4":"3.2E-04","AT-1":"2.9E-04","AT-2":"2.4E-04","AT-3":"2.5E-04","AT-4":"2.5E-04"},{"Metabolite":"N-Acetylornithine","WC-1":"6.4E-05","WC-2":"5.8E-05","WC-3":"6.6E-05","WC-4":"6.9E-05","WT-1":"8.4E-05","WT-2":"9.0E-05","WT-3":"1.0E-04","WT-4":"1.2E-04","AC-1":"5.5E-05","AC-2":"8.4E-05","AC-3":"4.7E-05","AC-4":"4.9E-05","AT-1":"9.4E-05","AT-2":"9.4E-05","AT-3":"9.2E-05","AT-4":"9.2E-05"},{"Metabolite":"N-Acetylphenylalanine","WC-1":"9.9E-04","WC-2":"4.8E-04","WC-3":"9.3E-04","WC-4":"8.9E-04","WT-1":"1.6E-03","WT-2":"1.2E-03","WT-3":"2.4E-03","WT-4":"1.9E-03","AC-1":"1.1E-03","AC-2":"6.2E-04","AC-3":"1.8E-04","AC-4":"8.8E-04","AT-1":"2.1E-03","AT-2":"1.6E-03","AT-3":"1.6E-03","AT-4":"1.1E-03"},{"Metabolite":"N-Acetylputrescine","WC-1":"3.6E-05","WC-2":"3.7E-05","WC-3":"2.8E-05","WC-4":"3.4E-05","WT-1":"4.5E-05","WT-2":"2.7E-05","WT-3":"2.6E-05","WT-4":"3.7E-05","AC-1":"2.7E-05","AC-2":"2.3E-05","AC-3":"2.0E-05","AC-4":"4.3E-05","AT-1":"3.8E-05","AT-2":"5.0E-05","AT-3":"5.6E-05","AT-4":"3.2E-05"},{"Metabolite":"N-Acetylserine","WC-1":"7.0E-04","WC-2":"7.7E-04","WC-3":"1.1E-03","WC-4":"7.3E-04","WT-1":"9.2E-04","WT-2":"8.1E-04","WT-3":"9.8E-04","WT-4":"9.3E-04","AC-1":"7.8E-04","AC-2":"7.2E-04","AC-3":"8.2E-04","AC-4":"7.6E-04","AT-1":"1.1E-03","AT-2":"9.1E-04","AT-3":"9.7E-04","AT-4":"8.0E-04"},{"Metabolite":"N-Acetyltryptophan","WC-1":"5.8E-04","WC-2":"4.4E-04","WC-3":"6.1E-04","WC-4":"5.3E-04","WT-1":"6.6E-04","WT-2":"4.9E-04","WT-3":"7.5E-04","WT-4":"7.2E-04","AC-1":"7.5E-04","AC-2":"4.9E-04","AC-3":"1.6E-04","AC-4":"5.1E-04","AT-1":"7.8E-04","AT-2":"7.6E-04","AT-3":"7.4E-04","AT-4":"6.4E-04"},{"Metabolite":"N-Acetyltyrosine","WC-1":"1.8E-04","WC-2":"9.8E-05","WC-3":"1.3E-04","WC-4":"2.2E-04","WT-1":"2.5E-04","WT-2":"1.9E-04","WT-3":"9.1E-05","WT-4":"3.6E-04","AC-1":"3.9E-04","AC-2":"2.1E-04","AC-3":"5.8E-05","AC-4":"2.2E-04","AT-1":"2.7E-04","AT-2":"4.2E-04","AT-3":"3.2E-04","AT-4":"2.1E-04"},{"Metabolite":"N-Ethylmaleimide_+H2O","WC-1":"8.8E-04","WC-2":"6.9E-04","WC-3":"1.7E-03","WC-4":"6.7E-04","WT-1":"9.4E-04","WT-2":"1.3E-03","WT-3":"1.6E-03","WT-4":"1.3E-03","AC-1":"1.2E-03","AC-2":"6.2E-04","AC-3":"N.D.","AC-4":"7.4E-04","AT-1":"1.1E-03","AT-2":"1.3E-03","AT-3":"1.1E-03","AT-4":"8.6E-04"},{"Metabolite":"N-Formylmethionine","WC-1":"1.0E-04","WC-2":"2.9E-04","WC-3":"4.5E-04","WC-4":"1.2E-04","WT-1":"3.6E-04","WT-2":"2.6E-04","WT-3":"5.0E-04","WT-4":"2.0E-04","AC-1":"7.5E-05","AC-2":"N.D.","AC-3":"1.4E-04","AC-4":"1.1E-04","AT-1":"2.8E-04","AT-2":"2.1E-04","AT-3":"2.6E-04","AT-4":"2.0E-04"},{"Metabolite":"N-Glycolylneuraminic acid","WC-1":"1.6E-04","WC-2":"3.2E-04","WC-3":"3.3E-04","WC-4":"1.6E-04","WT-1":"3.1E-04","WT-2":"2.7E-04","WT-3":"3.7E-04","WT-4":"2.9E-04","AC-1":"1.1E-04","AC-2":"4.2E-04","AC-3":"6.8E-04","AC-4":"2.4E-04","AT-1":"3.4E-04","AT-2":"2.6E-04","AT-3":"2.5E-04","AT-4":"3.2E-04"},{"Metabolite":"N-Methylproline","WC-1":"6.9E-04","WC-2":"5.2E-04","WC-3":"3.6E-04","WC-4":"6.5E-04","WT-1":"6.0E-04","WT-2":"3.7E-04","WT-3":"8.4E-04","WT-4":"8.9E-04","AC-1":"6.1E-04","AC-2":"8.0E-04","AC-3":"8.0E-04","AC-4":"6.2E-04","AT-1":"7.9E-04","AT-2":"6.8E-04","AT-3":"6.0E-04","AT-4":"6.0E-04"},{"Metabolite":"N1-Methyl-4-pyridone-5-carboxamide","WC-1":"3.4E-03","WC-2":"5.3E-03","WC-3":"7.2E-03","WC-4":"3.3E-03","WT-1":"1.4E-03","WT-2":"1.6E-03","WT-3":"1.5E-03","WT-4":"3.7E-03","AC-1":"4.3E-03","AC-2":"3.0E-03","AC-3":"4.3E-03","AC-4":"5.1E-03","AT-1":"2.9E-03","AT-2":"2.9E-03","AT-3":"2.2E-03","AT-4":"1.4E-03"},{"Metabolite":"N1-Methylguanosine","WC-1":"2.0E-04","WC-2":"1.8E-04","WC-3":"2.4E-04","WC-4":"1.7E-04","WT-1":"1.6E-04","WT-2":"1.7E-04","WT-3":"1.8E-04","WT-4":"1.8E-04","AC-1":"1.6E-04","AC-2":"1.1E-04","AC-3":"9.1E-05","AC-4":"1.8E-04","AT-1":"1.6E-04","AT-2":"1.8E-04","AT-3":"1.6E-04","AT-4":"1.3E-04"},{"Metabolite":"N2-Acetylaminoadipic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"5.6E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"N6,N6,N6-Trimethyllysine","WC-1":"4.3E-03","WC-2":"4.8E-03","WC-3":"4.2E-03","WC-4":"4.6E-03","WT-1":"4.3E-03","WT-2":"3.6E-03","WT-3":"4.2E-03","WT-4":"6.6E-03","AC-1":"3.6E-03","AC-2":"4.8E-03","AC-3":"6.4E-03","AC-4":"4.9E-03","AT-1":"6.2E-03","AT-2":"5.0E-03","AT-3":"5.1E-03","AT-4":"4.8E-03"},{"Metabolite":"N6-Acetyllysine","WC-1":"2.7E-03","WC-2":"2.5E-03","WC-3":"2.5E-03","WC-4":"2.8E-03","WT-1":"2.7E-03","WT-2":"2.3E-03","WT-3":"2.4E-03","WT-4":"3.6E-03","AC-1":"2.9E-03","AC-2":"3.6E-03","AC-3":"3.1E-03","AC-4":"2.9E-03","AT-1":"3.2E-03","AT-2":"3.3E-03","AT-3":"3.0E-03","AT-4":"2.7E-03"},{"Metabolite":"N6-Methyl-2'-deoxyadenosine","WC-1":"1.1E-05","WC-2":"1.3E-05","WC-3":"1.1E-05","WC-4":"2.6E-05","WT-1":"N.D.","WT-2":"N.D.","WT-3":"9.6E-06","WT-4":"N.D.","AC-1":"2.8E-05","AC-2":"1.8E-05","AC-3":"7.4E-06","AC-4":"N.D.","AT-1":"N.D.","AT-2":"2.0E-05","AT-3":"N.D.","AT-4":"2.5E-05"},{"Metabolite":"N6-Methyllysine","WC-1":"2.9E-02","WC-2":"2.0E-02","WC-3":"1.6E-02","WC-4":"2.8E-02","WT-1":"2.0E-02","WT-2":"1.6E-02","WT-3":"1.9E-02","WT-4":"2.8E-02","AC-1":"2.4E-02","AC-2":"2.8E-02","AC-3":"3.2E-02","AC-4":"3.1E-02","AT-1":"2.5E-02","AT-2":"2.4E-02","AT-3":"1.8E-02","AT-4":"1.9E-02"},{"Metabolite":"N8-Acetylspermidine","WC-1":"3.6E-04","WC-2":"4.4E-04","WC-3":"3.3E-04","WC-4":"4.2E-04","WT-1":"3.6E-04","WT-2":"2.5E-04","WT-3":"3.4E-04","WT-4":"4.8E-04","AC-1":"3.4E-04","AC-2":"3.3E-04","AC-3":"4.7E-04","AC-4":"5.9E-04","AT-1":"3.4E-04","AT-2":"5.1E-04","AT-3":"3.8E-04","AT-4":"3.1E-04"},{"Metabolite":"Nalidixic acid","WC-1":"3.3E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"5.8E-05","WT-2":"N.D.","WT-3":"6.2E-05","WT-4":"1.3E-04","AC-1":"N.D.","AC-2":"3.0E-05","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"1.0E-04","AT-3":"1.1E-04","AT-4":"8.2E-05"},{"Metabolite":"Nicotinamide","WC-1":"1.2E-02","WC-2":"1.3E-02","WC-3":"1.3E-02","WC-4":"9.1E-03","WT-1":"5.5E-03","WT-2":"7.2E-03","WT-3":"8.8E-03","WT-4":"1.8E-02","AC-1":"1.1E-02","AC-2":"1.0E-02","AC-3":"1.2E-02","AC-4":"1.4E-02","AT-1":"1.0E-02","AT-2":"7.7E-03","AT-3":"8.0E-03","AT-4":"6.0E-03"},{"Metabolite":"Noradrenaline　6-Hydroxydopamine","WC-1":"1.3E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"2.1E-05","WT-1":"1.7E-05","WT-2":"9.4E-06","WT-3":"N.D.","WT-4":"2.7E-05","AC-1":"2.3E-05","AC-2":"1.5E-05","AC-3":"N.D.","AC-4":"7.5E-06","AT-1":"1.7E-05","AT-2":"1.3E-05","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"N’-Formylkynurenine","WC-1":"1.1E-04","WC-2":"5.6E-05","WC-3":"4.3E-05","WC-4":"7.0E-05","WT-1":"7.2E-05","WT-2":"4.6E-05","WT-3":"4.0E-05","WT-4":"5.3E-05","AC-1":"1.3E-04","AC-2":"1.4E-04","AC-3":"1.4E-04","AC-4":"9.8E-05","AT-1":"9.3E-05","AT-2":"7.0E-05","AT-3":"9.8E-05","AT-4":"1.2E-04"},{"Metabolite":"Nω-Methylarginine","WC-1":"7.9E-04","WC-2":"6.4E-04","WC-3":"4.0E-04","WC-4":"9.8E-04","WT-1":"7.1E-04","WT-2":"5.5E-04","WT-3":"5.2E-04","WT-4":"7.7E-04","AC-1":"9.3E-04","AC-2":"1.1E-03","AC-3":"9.2E-04","AC-4":"8.9E-04","AT-1":"7.3E-04","AT-2":"8.7E-04","AT-3":"6.7E-04","AT-4":"6.2E-04"},{"Metabolite":"O-Acetylcarnitine","WC-1":"1.8E-01","WC-2":"1.5E-01","WC-3":"1.4E-01","WC-4":"1.5E-01","WT-1":"1.6E-01","WT-2":"1.7E-01","WT-3":"1.9E-01","WT-4":"2.0E-01","AC-1":"1.9E-01","AC-2":"1.9E-01","AC-3":"1.6E-01","AC-4":"2.2E-01","AT-1":"2.1E-01","AT-2":"2.1E-01","AT-3":"2.2E-01","AT-4":"2.3E-01"},{"Metabolite":"o-Hydroxybenzoic acid","WC-1":"1.9E-03","WC-2":"N.D.","WC-3":"N.D.","WC-4":"2.0E-03","WT-1":"2.7E-03","WT-2":"9.2E-04","WT-3":"1.6E-03","WT-4":"4.3E-03","AC-1":"2.0E-03","AC-2":"1.9E-03","AC-3":"9.4E-04","AC-4":"1.5E-03","AT-1":"2.1E-03","AT-2":"1.8E-03","AT-3":"1.3E-03","AT-4":"1.4E-03"},{"Metabolite":"O-Sulfoserine","WC-1":"1.3E-04","WC-2":"N.D.","WC-3":"1.7E-04","WC-4":"1.7E-04","WT-1":"2.2E-04","WT-2":"1.9E-04","WT-3":"1.8E-04","WT-4":"N.D.","AC-1":"1.3E-04","AC-2":"1.7E-04","AC-3":"2.5E-04","AC-4":"1.6E-04","AT-1":"1.8E-04","AT-2":"1.7E-04","AT-3":"1.8E-04","AT-4":"1.6E-04"},{"Metabolite":"Octanoylcarnitine","WC-1":"1.0E-04","WC-2":"6.7E-05","WC-3":"1.3E-04","WC-4":"1.1E-04","WT-1":"1.3E-04","WT-2":"1.5E-04","WT-3":"4.5E-04","WT-4":"1.6E-04","AC-1":"7.7E-05","AC-2":"N.D.","AC-3":"N.D.","AC-4":"1.1E-04","AT-1":"1.7E-04","AT-2":"1.7E-04","AT-3":"1.2E-04","AT-4":"1.1E-04"},{"Metabolite":"Octopine","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"2.7E-04"},{"Metabolite":"Ophthalmic acid","WC-1":"9.8E-04","WC-2":"8.8E-04","WC-3":"3.1E-03","WC-4":"9.7E-04","WT-1":"4.9E-03","WT-2":"5.6E-03","WT-3":"8.5E-03","WT-4":"4.2E-03","AC-1":"6.1E-04","AC-2":"5.1E-04","AC-3":"4.1E-04","AC-4":"8.1E-04","AT-1":"3.2E-03","AT-2":"3.2E-03","AT-3":"3.3E-03","AT-4":"3.8E-03"},{"Metabolite":"Ornithine","WC-1":"7.0E-02","WC-2":"7.0E-02","WC-3":"5.0E-02","WC-4":"7.6E-02","WT-1":"6.5E-02","WT-2":"6.3E-02","WT-3":"7.2E-02","WT-4":"9.1E-02","AC-1":"8.7E-02","AC-2":"9.8E-02","AC-3":"1.0E-01","AC-4":"7.4E-02","AT-1":"7.9E-02","AT-2":"7.6E-02","AT-3":"9.9E-02","AT-4":"8.5E-02"},{"Metabolite":"Orotic acid","WC-1":"2.5E-04","WC-2":"5.5E-04","WC-3":"4.4E-04","WC-4":"2.8E-04","WT-1":"5.9E-04","WT-2":"6.8E-04","WT-3":"5.6E-04","WT-4":"4.5E-04","AC-1":"2.8E-04","AC-2":"5.0E-04","AC-3":"6.6E-04","AC-4":"2.9E-04","AT-1":"6.2E-04","AT-2":"6.7E-04","AT-3":"7.2E-04","AT-4":"7.5E-04"},{"Metabolite":"Orotidine","WC-1":"2.9E-05","WC-2":"5.4E-05","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"5.3E-05","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"5.7E-05","AC-4":"4.7E-05","AT-1":"8.4E-05","AT-2":"6.3E-05","AT-3":"N.D.","AT-4":"5.6E-05"},{"Metabolite":"p-Hydroxymandelic acid　Homogentisic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"1.7E-04","WT-1":"N.D.","WT-2":"8.8E-05","WT-3":"9.5E-05","WT-4":"2.1E-04","AC-1":"1.2E-04","AC-2":"1.1E-04","AC-3":"N.D.","AC-4":"1.3E-04","AT-1":"1.5E-04","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"p-Hydroxyphenylpyruvic acid","WC-1":"1.7E-03","WC-2":"1.4E-03","WC-3":"2.3E-03","WC-4":"2.9E-03","WT-1":"2.8E-03","WT-2":"1.6E-03","WT-3":"2.2E-03","WT-4":"3.2E-03","AC-1":"1.4E-03","AC-2":"1.1E-03","AC-3":"N.D.","AC-4":"1.6E-03","AT-1":"2.9E-03","AT-2":"2.7E-03","AT-3":"1.9E-03","AT-4":"2.0E-03"},{"Metabolite":"Pantothenic acid","WC-1":"2.8E-03","WC-2":"1.2E-03","WC-3":"1.2E-03","WC-4":"3.1E-03","WT-1":"2.1E-03","WT-2":"1.2E-03","WT-3":"8.0E-04","WT-4":"3.4E-03","AC-1":"3.4E-03","AC-2":"2.9E-03","AC-3":"1.2E-03","AC-4":"3.0E-03","AT-1":"2.3E-03","AT-2":"2.9E-03","AT-3":"1.7E-03","AT-4":"1.6E-03"},{"Metabolite":"Pargyline","WC-1":"1.3E-04","WC-2":"N.D.","WC-3":"N.D.","WC-4":"7.2E-05","WT-1":"4.6E-05","WT-2":"4.5E-05","WT-3":"5.5E-05","WT-4":"N.D.","AC-1":"6.7E-05","AC-2":"8.1E-05","AC-3":"N.D.","AC-4":"7.8E-05","AT-1":"8.3E-05","AT-2":"N.D.","AT-3":"1.3E-05","AT-4":"4.5E-05"},{"Metabolite":"Perillic acid","WC-1":"1.2E-03","WC-2":"4.9E-04","WC-3":"8.1E-04","WC-4":"8.1E-04","WT-1":"7.7E-04","WT-2":"8.3E-04","WT-3":"8.1E-04","WT-4":"8.2E-04","AC-1":"1.0E-03","AC-2":"8.1E-04","AC-3":"7.5E-04","AC-4":"9.7E-04","AT-1":"6.5E-04","AT-2":"1.1E-03","AT-3":"9.6E-04","AT-4":"9.0E-04"},{"Metabolite":"Phe","WC-1":"4.2E-01","WC-2":"3.9E-01","WC-3":"3.6E-01","WC-4":"3.8E-01","WT-1":"4.8E-01","WT-2":"3.7E-01","WT-3":"4.2E-01","WT-4":"4.4E-01","AC-1":"5.5E-01","AC-2":"4.5E-01","AC-3":"3.7E-01","AC-4":"4.6E-01","AT-1":"5.0E-01","AT-2":"5.1E-01","AT-3":"5.5E-01","AT-4":"4.7E-01"},{"Metabolite":"Phenaceturic acid　N-(o-Toluoyl)glycine","WC-1":"1.3E-03","WC-2":"5.5E-04","WC-3":"1.2E-03","WC-4":"8.8E-04","WT-1":"2.8E-04","WT-2":"1.4E-04","WT-3":"3.2E-04","WT-4":"5.0E-04","AC-1":"2.6E-04","AC-2":"2.1E-04","AC-3":"9.1E-05","AC-4":"2.6E-04","AT-1":"6.1E-04","AT-2":"5.8E-04","AT-3":"2.5E-04","AT-4":"2.1E-04"},{"Metabolite":"Phenol","WC-1":"N.D.","WC-2":"7.9E-04","WC-3":"1.1E-03","WC-4":"9.2E-04","WT-1":"1.1E-03","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"1.0E-03","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"1.1E-03","AT-3":"1.1E-03","AT-4":"9.8E-04"},{"Metabolite":"Phosphocreatine","WC-1":"2.3E-04","WC-2":"3.9E-04","WC-3":"2.0E-04","WC-4":"2.0E-04","WT-1":"2.1E-04","WT-2":"3.5E-04","WT-3":"1.9E-04","WT-4":"1.6E-04","AC-1":"3.2E-04","AC-2":"4.9E-04","AC-3":"7.8E-04","AC-4":"3.3E-04","AT-1":"3.0E-04","AT-2":"1.8E-04","AT-3":"2.5E-04","AT-4":"4.1E-04"},{"Metabolite":"Phosphorylcholine","WC-1":"7.1E-03","WC-2":"9.1E-03","WC-3":"7.2E-03","WC-4":"1.6E-02","WT-1":"9.5E-03","WT-2":"8.0E-03","WT-3":"8.1E-03","WT-4":"1.5E-02","AC-1":"7.6E-03","AC-2":"1.2E-02","AC-3":"1.1E-02","AC-4":"1.1E-02","AT-1":"7.4E-03","AT-2":"8.8E-03","AT-3":"9.1E-03","AT-4":"7.0E-03"},{"Metabolite":"Phthalic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"1.2E-04","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Picolinic acid","WC-1":"9.7E-04","WC-2":"N.D.","WC-3":"N.D.","WC-4":"7.8E-04","WT-1":"5.3E-04","WT-2":"5.2E-04","WT-3":"4.8E-04","WT-4":"1.2E-03","AC-1":"9.2E-04","AC-2":"7.9E-04","AC-3":"N.D.","AC-4":"5.9E-04","AT-1":"8.6E-04","AT-2":"7.6E-04","AT-3":"6.5E-04","AT-4":"N.D."},{"Metabolite":"Pipecolic acid","WC-1":"1.4E-02","WC-2":"2.3E-02","WC-3":"2.1E-02","WC-4":"1.3E-02","WT-1":"1.7E-02","WT-2":"2.0E-02","WT-3":"2.3E-02","WT-4":"1.6E-02","AC-1":"1.2E-02","AC-2":"1.8E-02","AC-3":"2.5E-02","AC-4":"1.7E-02","AT-1":"2.4E-02","AT-2":"2.4E-02","AT-3":"2.2E-02","AT-4":"1.9E-02"},{"Metabolite":"Piperidine","WC-1":"4.4E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"6.0E-05","WT-2":"6.1E-05","WT-3":"1.2E-04","WT-4":"8.7E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"5.5E-05","AT-3":"7.0E-05","AT-4":"N.D."},{"Metabolite":"Pro","WC-1":"2.2E-01","WC-2":"2.4E-01","WC-3":"1.5E-01","WC-4":"2.1E-01","WT-1":"2.1E-01","WT-2":"1.7E-01","WT-3":"1.8E-01","WT-4":"2.4E-01","AC-1":"3.2E-01","AC-2":"3.0E-01","AC-3":"3.2E-01","AC-4":"2.3E-01","AT-1":"2.8E-01","AT-2":"2.3E-01","AT-3":"3.0E-01","AT-4":"2.6E-01"},{"Metabolite":"Propionic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"1.5E-03","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"1.3E-03","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"2.0E-03","AT-4":"1.9E-03"},{"Metabolite":"Prostaglandin E2","WC-1":"3.5E-04","WC-2":"N.D.","WC-3":"N.D.","WC-4":"1.5E-04","WT-1":"1.7E-04","WT-2":"N.D.","WT-3":"N.D.","WT-4":"2.0E-04","AC-1":"7.6E-05","AC-2":"5.3E-05","AC-3":"N.D.","AC-4":"7.6E-05","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Putrescine","WC-1":"1.5E-04","WC-2":"2.5E-04","WC-3":"1.9E-04","WC-4":"1.7E-04","WT-1":"2.2E-04","WT-2":"2.5E-04","WT-3":"3.0E-04","WT-4":"2.6E-04","AC-1":"1.4E-04","AC-2":"2.1E-04","AC-3":"1.7E-04","AC-4":"2.6E-04","AT-1":"2.1E-04","AT-2":"2.3E-04","AT-3":"2.2E-04","AT-4":"2.2E-04"},{"Metabolite":"Pyridoxal","WC-1":"1.2E-03","WC-2":"4.5E-04","WC-3":"4.8E-04","WC-4":"1.2E-03","WT-1":"9.4E-04","WT-2":"4.1E-04","WT-3":"4.5E-04","WT-4":"1.6E-03","AC-1":"1.5E-03","AC-2":"1.4E-03","AC-3":"5.0E-04","AC-4":"1.0E-03","AT-1":"8.5E-04","AT-2":"1.4E-03","AT-3":"6.4E-04","AT-4":"6.3E-04"},{"Metabolite":"Pyridoxamine","WC-1":"7.2E-06","WC-2":"N.D.","WC-3":"N.D.","WC-4":"1.1E-05","WT-1":"1.1E-05","WT-2":"N.D.","WT-3":"N.D.","WT-4":"2.2E-05","AC-1":"N.D.","AC-2":"2.1E-05","AC-3":"N.D.","AC-4":"1.2E-05","AT-1":"N.D.","AT-2":"1.7E-05","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Pyridoxine","WC-1":"2.0E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"9.9E-06","WT-1":"2.3E-05","WT-2":"1.3E-05","WT-3":"N.D.","WT-4":"2.4E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"9.6E-06","AC-4":"1.2E-05","AT-1":"2.0E-05","AT-2":"1.3E-05","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Pyruvic acid","WC-1":"3.7E-03","WC-2":"4.4E-03","WC-3":"3.8E-03","WC-4":"3.7E-03","WT-1":"6.0E-03","WT-2":"5.2E-03","WT-3":"5.9E-03","WT-4":"5.5E-03","AC-1":"3.6E-03","AC-2":"5.4E-03","AC-3":"5.4E-03","AC-4":"2.8E-03","AT-1":"7.2E-03","AT-2":"5.6E-03","AT-3":"4.8E-03","AT-4":"6.1E-03"},{"Metabolite":"Quinolinic acid","WC-1":"N.D.","WC-2":"7.7E-05","WC-3":"1.2E-04","WC-4":"1.5E-04","WT-1":"N.D.","WT-2":"9.9E-05","WT-3":"N.D.","WT-4":"2.3E-04","AC-1":"1.1E-04","AC-2":"N.D.","AC-3":"N.D.","AC-4":"9.4E-05","AT-1":"2.1E-04","AT-2":"1.3E-04","AT-3":"1.1E-04","AT-4":"1.1E-04"},{"Metabolite":"Retinoic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"2.8E-05","WT-1":"1.7E-04","WT-2":"5.6E-05","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"8.9E-05","AC-3":"5.1E-05","AC-4":"N.D.","AT-1":"N.D.","AT-2":"5.4E-05","AT-3":"N.D.","AT-4":"5.8E-05"},{"Metabolite":"Riboflavin","WC-1":"2.5E-04","WC-2":"1.4E-04","WC-3":"9.3E-05","WC-4":"2.0E-04","WT-1":"2.2E-04","WT-2":"2.0E-04","WT-3":"1.2E-04","WT-4":"2.9E-04","AC-1":"2.6E-04","AC-2":"2.2E-04","AC-3":"1.4E-04","AC-4":"1.6E-04","AT-1":"1.2E-04","AT-2":"2.4E-04","AT-3":"1.9E-04","AT-4":"1.8E-04"},{"Metabolite":"Ribose 5-phosphate","WC-1":"6.8E-05","WC-2":"9.5E-05","WC-3":"1.2E-04","WC-4":"1.0E-04","WT-1":"1.0E-04","WT-2":"1.6E-04","WT-3":"N.D.","WT-4":"2.5E-04","AC-1":"N.D.","AC-2":"9.0E-05","AC-3":"N.D.","AC-4":"1.1E-04","AT-1":"1.8E-04","AT-2":"1.3E-04","AT-3":"1.2E-04","AT-4":"1.0E-04"},{"Metabolite":"Ribulose 5-phosphate","WC-1":"2.4E-03","WC-2":"1.4E-03","WC-3":"1.6E-03","WC-4":"3.1E-03","WT-1":"5.4E-03","WT-2":"3.6E-03","WT-3":"4.4E-03","WT-4":"7.5E-03","AC-1":"1.8E-03","AC-2":"2.5E-03","AC-3":"8.8E-04","AC-4":"2.6E-03","AT-1":"6.0E-03","AT-2":"6.5E-03","AT-3":"2.5E-03","AT-4":"3.2E-03"},{"Metabolite":"S-Adenosylhomocysteine","WC-1":"2.3E-04","WC-2":"1.9E-04","WC-3":"2.0E-04","WC-4":"1.4E-04","WT-1":"3.9E-04","WT-2":"6.4E-04","WT-3":"1.1E-03","WT-4":"3.0E-04","AC-1":"1.4E-04","AC-2":"6.2E-05","AC-3":"N.D.","AC-4":"1.7E-04","AT-1":"8.2E-04","AT-2":"3.0E-04","AT-3":"5.8E-04","AT-4":"3.2E-04"},{"Metabolite":"S-Adenosylmethionine","WC-1":"1.8E-04","WC-2":"1.9E-04","WC-3":"2.0E-04","WC-4":"1.6E-04","WT-1":"1.7E-04","WT-2":"1.7E-04","WT-3":"1.8E-04","WT-4":"2.2E-04","AC-1":"1.4E-04","AC-2":"9.3E-05","AC-3":"2.3E-04","AC-4":"1.8E-04","AT-1":"2.4E-04","AT-2":"2.2E-04","AT-3":"1.7E-04","AT-4":"1.7E-04"},{"Metabolite":"S-Carboxymethylcysteine","WC-1":"5.0E-05","WC-2":"5.4E-05","WC-3":"3.9E-05","WC-4":"5.6E-05","WT-1":"5.8E-05","WT-2":"6.4E-05","WT-3":"4.5E-05","WT-4":"6.8E-05","AC-1":"6.2E-05","AC-2":"6.0E-05","AC-3":"5.4E-05","AC-4":"5.6E-05","AT-1":"6.2E-05","AT-2":"3.2E-05","AT-3":"5.6E-05","AT-4":"5.2E-05"},{"Metabolite":"S-Lactoylglutathione","WC-1":"N.D.","WC-2":"N.D.","WC-3":"2.0E-05","WC-4":"N.D.","WT-1":"N.D.","WT-2":"1.0E-05","WT-3":"1.7E-05","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"2.2E-05","AT-4":"N.D."},{"Metabolite":"S-Methylcysteine","WC-1":"1.4E-03","WC-2":"9.5E-04","WC-3":"1.3E-03","WC-4":"1.0E-03","WT-1":"8.1E-04","WT-2":"7.8E-04","WT-3":"8.2E-04","WT-4":"7.5E-04","AC-1":"1.0E-03","AC-2":"9.8E-04","AC-3":"9.9E-04","AC-4":"1.6E-03","AT-1":"6.9E-04","AT-2":"1.0E-03","AT-3":"7.3E-04","AT-4":"7.6E-04"},{"Metabolite":"S-Methylglutathione","WC-1":"3.9E-04","WC-2":"3.6E-04","WC-3":"7.2E-04","WC-4":"5.2E-04","WT-1":"1.0E-03","WT-2":"1.1E-03","WT-3":"1.1E-03","WT-4":"1.4E-03","AC-1":"3.1E-04","AC-2":"2.7E-04","AC-3":"7.8E-05","AC-4":"6.0E-04","AT-1":"8.3E-04","AT-2":"1.1E-03","AT-3":"9.7E-04","AT-4":"9.7E-04"},{"Metabolite":"S-Methylmethionine","WC-1":"2.6E-04","WC-2":"2.8E-04","WC-3":"2.5E-04","WC-4":"2.3E-04","WT-1":"3.1E-04","WT-2":"2.9E-04","WT-3":"5.2E-04","WT-4":"3.3E-04","AC-1":"2.7E-04","AC-2":"4.0E-04","AC-3":"4.6E-04","AC-4":"3.7E-04","AT-1":"4.2E-04","AT-2":"2.6E-04","AT-3":"2.8E-04","AT-4":"4.2E-04"},{"Metabolite":"S-Sulfocysteine","WC-1":"1.0E-03","WC-2":"1.7E-03","WC-3":"1.0E-03","WC-4":"8.2E-04","WT-1":"1.3E-03","WT-2":"2.4E-03","WT-3":"4.5E-04","WT-4":"4.0E-04","AC-1":"7.5E-03","AC-2":"3.2E-03","AC-3":"2.2E-03","AC-4":"1.2E-03","AT-1":"1.4E-03","AT-2":"1.9E-03","AT-3":"2.4E-03","AT-4":"3.5E-03"},{"Metabolite":"Saccharopine","WC-1":"2.9E-05","WC-2":"2.8E-05","WC-3":"N.D.","WC-4":"3.8E-05","WT-1":"2.2E-05","WT-2":"3.6E-05","WT-3":"6.9E-05","WT-4":"1.1E-04","AC-1":"2.6E-05","AC-2":"1.9E-05","AC-3":"1.4E-04","AC-4":"1.2E-04","AT-1":"1.7E-04","AT-2":"1.1E-04","AT-3":"5.1E-05","AT-4":"5.7E-05"},{"Metabolite":"Sarcosine","WC-1":"4.4E-03","WC-2":"2.7E-03","WC-3":"2.0E-03","WC-4":"4.9E-03","WT-1":"3.2E-03","WT-2":"2.4E-03","WT-3":"3.7E-03","WT-4":"7.4E-03","AC-1":"3.8E-03","AC-2":"4.8E-03","AC-3":"2.7E-03","AC-4":"5.8E-03","AT-1":"5.3E-03","AT-2":"5.0E-03","AT-3":"4.4E-03","AT-4":"2.9E-03"},{"Metabolite":"SDMA","WC-1":"1.1E-03","WC-2":"1.1E-03","WC-3":"1.2E-03","WC-4":"1.1E-03","WT-1":"9.1E-04","WT-2":"8.6E-04","WT-3":"9.6E-04","WT-4":"9.1E-04","AC-1":"1.1E-03","AC-2":"9.9E-04","AC-3":"1.2E-03","AC-4":"1.4E-03","AT-1":"1.2E-03","AT-2":"1.3E-03","AT-3":"1.2E-03","AT-4":"1.1E-03"},{"Metabolite":"Sebacic acid","WC-1":"N.D.","WC-2":"2.9E-04","WC-3":"N.D.","WC-4":"N.D.","WT-1":"3.0E-04","WT-2":"5.6E-04","WT-3":"6.3E-04","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"3.9E-04","AT-2":"2.4E-04","AT-3":"6.3E-04","AT-4":"5.4E-04"},{"Metabolite":"Sedoheptulose 7-phosphate","WC-1":"7.1E-05","WC-2":"1.8E-04","WC-3":"3.7E-04","WC-4":"2.1E-04","WT-1":"2.9E-04","WT-2":"2.9E-04","WT-3":"3.8E-04","WT-4":"6.3E-04","AC-1":"5.8E-05","AC-2":"1.2E-04","AC-3":"9.7E-05","AC-4":"2.5E-04","AT-1":"2.7E-04","AT-2":"1.8E-04","AT-3":"2.3E-04","AT-4":"1.1E-04"},{"Metabolite":"Ser","WC-1":"7.9E-02","WC-2":"8.2E-02","WC-3":"5.2E-02","WC-4":"7.4E-02","WT-1":"7.9E-02","WT-2":"6.2E-02","WT-3":"5.2E-02","WT-4":"6.3E-02","AC-1":"1.2E-01","AC-2":"1.2E-01","AC-3":"1.1E-01","AC-4":"9.1E-02","AT-1":"8.7E-02","AT-2":"8.2E-02","AT-3":"1.0E-01","AT-4":"1.0E-01"},{"Metabolite":"Serotonin","WC-1":"3.9E-03","WC-2":"2.9E-04","WC-3":"5.3E-05","WC-4":"5.6E-04","WT-1":"1.9E-03","WT-2":"1.2E-03","WT-3":"4.0E-04","WT-4":"9.7E-03","AC-1":"1.1E-03","AC-2":"2.6E-03","AC-3":"2.1E-03","AC-4":"3.2E-03","AT-1":"1.3E-03","AT-2":"1.7E-03","AT-3":"2.3E-03","AT-4":"1.7E-03"},{"Metabolite":"Spermidine","WC-1":"1.5E-03","WC-2":"1.9E-03","WC-3":"1.3E-03","WC-4":"1.7E-03","WT-1":"2.5E-03","WT-2":"2.1E-03","WT-3":"2.4E-03","WT-4":"2.5E-03","AC-1":"1.2E-03","AC-2":"1.4E-03","AC-3":"2.0E-03","AC-4":"1.8E-03","AT-1":"1.9E-03","AT-2":"2.6E-03","AT-3":"1.7E-03","AT-4":"1.7E-03"},{"Metabolite":"Spermine","WC-1":"5.8E-05","WC-2":"1.1E-04","WC-3":"6.2E-05","WC-4":"8.6E-05","WT-1":"9.9E-05","WT-2":"1.2E-04","WT-3":"1.0E-04","WT-4":"1.1E-04","AC-1":"5.6E-05","AC-2":"6.6E-05","AC-3":"7.3E-05","AC-4":"7.9E-05","AT-1":"8.6E-05","AT-2":"9.3E-05","AT-3":"7.6E-05","AT-4":"5.9E-05"},{"Metabolite":"Stachydrine","WC-1":"4.7E-02","WC-2":"5.1E-02","WC-3":"3.9E-02","WC-4":"4.9E-02","WT-1":"3.9E-02","WT-2":"3.9E-02","WT-3":"4.9E-02","WT-4":"5.9E-02","AC-1":"5.2E-02","AC-2":"6.2E-02","AC-3":"5.0E-02","AC-4":"5.6E-02","AT-1":"7.0E-02","AT-2":"5.2E-02","AT-3":"6.6E-02","AT-4":"5.5E-02"},{"Metabolite":"Suberic acid","WC-1":"N.D.","WC-2":"6.3E-05","WC-3":"N.D.","WC-4":"N.D.","WT-1":"2.2E-04","WT-2":"1.3E-04","WT-3":"2.7E-04","WT-4":"2.2E-04","AC-1":"8.0E-05","AC-2":"N.D.","AC-3":"N.D.","AC-4":"1.1E-04","AT-1":"1.4E-04","AT-2":"1.9E-04","AT-3":"1.6E-04","AT-4":"1.2E-04"},{"Metabolite":"Succinic acid","WC-1":"4.3E-02","WC-2":"3.7E-02","WC-3":"6.0E-02","WC-4":"5.1E-02","WT-1":"9.2E-02","WT-2":"7.8E-02","WT-3":"1.8E-01","WT-4":"2.0E-01","AC-1":"2.8E-02","AC-2":"2.3E-02","AC-3":"N.D.","AC-4":"4.8E-02","AT-1":"9.8E-02","AT-2":"8.6E-02","AT-3":"7.2E-02","AT-4":"4.8E-02"},{"Metabolite":"Sulfotyrosine","WC-1":"1.2E-04","WC-2":"1.5E-04","WC-3":"9.1E-05","WC-4":"1.3E-04","WT-1":"1.3E-04","WT-2":"1.1E-04","WT-3":"1.5E-04","WT-4":"1.8E-04","AC-1":"9.5E-05","AC-2":"1.2E-04","AC-3":"1.7E-04","AC-4":"1.1E-04","AT-1":"1.2E-04","AT-2":"1.5E-04","AT-3":"1.2E-04","AT-4":"1.3E-04"},{"Metabolite":"Taurine","WC-1":"1.0E-01","WC-2":"1.7E-01","WC-3":"1.2E-01","WC-4":"1.2E-01","WT-1":"1.1E-01","WT-2":"1.5E-01","WT-3":"1.2E-01","WT-4":"1.3E-01","AC-1":"2.7E-01","AC-2":"2.7E-01","AC-3":"2.5E-01","AC-4":"2.1E-01","AT-1":"2.7E-01","AT-2":"1.4E-01","AT-3":"2.0E-01","AT-4":"1.9E-01"},{"Metabolite":"Taurocholic acid","WC-1":"3.3E-03","WC-2":"4.0E-04","WC-3":"3.5E-04","WC-4":"2.2E-03","WT-1":"1.0E-01","WT-2":"2.7E-02","WT-3":"9.0E-04","WT-4":"2.6E-03","AC-1":"1.3E-01","AC-2":"1.0E-01","AC-3":"9.2E-04","AC-4":"2.9E-03","AT-1":"2.1E-03","AT-2":"1.0E-01","AT-3":"9.2E-02","AT-4":"9.2E-02"},{"Metabolite":"Taurocyamine","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"1.2E-04","AC-2":"1.8E-04","AC-3":"9.1E-05","AC-4":"1.6E-04","AT-1":"1.4E-04","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Thiamine","WC-1":"9.0E-04","WC-2":"1.4E-03","WC-3":"1.6E-03","WC-4":"8.6E-04","WT-1":"1.1E-03","WT-2":"1.0E-03","WT-3":"2.1E-03","WT-4":"9.4E-04","AC-1":"6.5E-04","AC-2":"4.9E-04","AC-3":"9.7E-04","AC-4":"1.0E-03","AT-1":"1.3E-03","AT-2":"1.1E-03","AT-3":"1.7E-03","AT-4":"1.5E-03"},{"Metabolite":"Thiamine diphosphate","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"3.4E-05","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Thiamine phosphate","WC-1":"3.7E-04","WC-2":"4.6E-04","WC-3":"4.2E-04","WC-4":"4.3E-04","WT-1":"3.3E-04","WT-2":"3.0E-04","WT-3":"4.6E-04","WT-4":"4.0E-04","AC-1":"2.2E-04","AC-2":"2.9E-04","AC-3":"4.9E-04","AC-4":"3.8E-04","AT-1":"4.2E-04","AT-2":"3.4E-04","AT-3":"5.0E-04","AT-4":"4.3E-04"},{"Metabolite":"Thiaproline","WC-1":"1.1E-04","WC-2":"2.7E-04","WC-3":"6.3E-04","WC-4":"8.9E-05","WT-1":"2.0E-04","WT-2":"2.2E-04","WT-3":"1.7E-04","WT-4":"1.2E-04","AC-1":"1.2E-04","AC-2":"1.2E-04","AC-3":"3.4E-04","AC-4":"1.0E-04","AT-1":"1.2E-04","AT-2":"9.9E-05","AT-3":"2.5E-04","AT-4":"4.5E-04"},{"Metabolite":"Thr","WC-1":"1.8E-01","WC-2":"1.8E-01","WC-3":"1.2E-01","WC-4":"1.9E-01","WT-1":"1.5E-01","WT-2":"1.3E-01","WT-3":"1.5E-01","WT-4":"1.7E-01","AC-1":"2.0E-01","AC-2":"2.3E-01","AC-3":"2.4E-01","AC-4":"2.0E-01","AT-1":"2.2E-01","AT-2":"1.7E-01","AT-3":"1.8E-01","AT-4":"1.7E-01"},{"Metabolite":"threo-β-Methylaspartic acid","WC-1":"1.8E-04","WC-2":"6.1E-04","WC-3":"6.7E-04","WC-4":"N.D.","WT-1":"4.5E-04","WT-2":"3.9E-04","WT-3":"6.6E-04","WT-4":"N.D.","AC-1":"N.D.","AC-2":"3.4E-04","AC-3":"4.4E-04","AC-4":"N.D.","AT-1":"4.7E-04","AT-2":"5.0E-04","AT-3":"4.1E-04","AT-4":"4.2E-04"},{"Metabolite":"Threonic acid","WC-1":"7.7E-03","WC-2":"8.3E-03","WC-3":"6.4E-03","WC-4":"7.2E-03","WT-1":"7.4E-03","WT-2":"8.3E-03","WT-3":"1.0E-02","WT-4":"8.9E-03","AC-1":"6.9E-03","AC-2":"9.7E-03","AC-3":"8.8E-03","AC-4":"8.6E-03","AT-1":"1.2E-02","AT-2":"9.4E-03","AT-3":"6.7E-03","AT-4":"6.7E-03"},{"Metabolite":"Thymidine","WC-1":"4.8E-03","WC-2":"3.5E-03","WC-3":"3.5E-03","WC-4":"4.8E-03","WT-1":"3.0E-03","WT-2":"3.4E-03","WT-3":"3.0E-03","WT-4":"4.1E-03","AC-1":"1.6E-03","AC-2":"1.5E-03","AC-3":"1.4E-03","AC-4":"9.9E-04","AT-1":"9.0E-04","AT-2":"1.4E-03","AT-3":"1.2E-03","AT-4":"1.3E-03"},{"Metabolite":"Thymine","WC-1":"6.8E-03","WC-2":"4.9E-03","WC-3":"4.9E-03","WC-4":"6.3E-03","WT-1":"3.9E-03","WT-2":"4.7E-03","WT-3":"4.1E-03","WT-4":"5.6E-03","AC-1":"2.1E-03","AC-2":"2.1E-03","AC-3":"2.1E-03","AC-4":"1.5E-03","AT-1":"1.4E-03","AT-2":"2.0E-03","AT-3":"1.7E-03","AT-4":"1.9E-03"},{"Metabolite":"trans-Cinnamic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"1.9E-04","WT-2":"1.6E-04","WT-3":"N.D.","WT-4":"N.D.","AC-1":"2.3E-04","AC-2":"2.1E-04","AC-3":"1.9E-04","AC-4":"1.4E-04","AT-1":"2.1E-04","AT-2":"1.5E-04","AT-3":"2.6E-04","AT-4":"2.5E-04"},{"Metabolite":"trans-Glutaconic acid","WC-1":"7.9E-04","WC-2":"7.7E-04","WC-3":"7.6E-04","WC-4":"7.6E-04","WT-1":"1.5E-03","WT-2":"1.2E-03","WT-3":"1.7E-03","WT-4":"2.1E-03","AC-1":"7.9E-04","AC-2":"7.5E-04","AC-3":"N.D.","AC-4":"7.0E-04","AT-1":"1.3E-03","AT-2":"1.3E-03","AT-3":"1.7E-03","AT-4":"1.2E-03"},{"Metabolite":"Triethanolamine","WC-1":"1.3E-04","WC-2":"1.5E-04","WC-3":"1.2E-04","WC-4":"2.3E-04","WT-1":"1.1E-04","WT-2":"1.1E-04","WT-3":"1.6E-04","WT-4":"1.1E-04","AC-1":"1.0E-04","AC-2":"1.7E-04","AC-3":"1.8E-04","AC-4":"3.3E-04","AT-1":"1.8E-04","AT-2":"1.6E-04","AT-3":"2.6E-04","AT-4":"1.9E-04"},{"Metabolite":"Trigonelline","WC-1":"1.9E-02","WC-2":"1.5E-02","WC-3":"1.0E-02","WC-4":"2.2E-02","WT-1":"1.6E-02","WT-2":"1.2E-02","WT-3":"1.7E-02","WT-4":"2.7E-02","AC-1":"1.8E-02","AC-2":"2.0E-02","AC-3":"1.7E-02","AC-4":"2.2E-02","AT-1":"2.4E-02","AT-2":"1.9E-02","AT-3":"1.6E-02","AT-4":"1.3E-02"},{"Metabolite":"Trimethylamine","WC-1":"5.2E-04","WC-2":"N.D.","WC-3":"1.5E-04","WC-4":"2.3E-04","WT-1":"3.3E-04","WT-2":"1.9E-04","WT-3":"6.5E-04","WT-4":"7.9E-04","AC-1":"1.7E-04","AC-2":"N.D.","AC-3":"N.D.","AC-4":"1.8E-04","AT-1":"3.3E-04","AT-2":"2.5E-04","AT-3":"2.7E-04","AT-4":"2.2E-04"},{"Metabolite":"Trimethylamine N-oxide","WC-1":"3.9E-02","WC-2":"4.8E-03","WC-3":"5.3E-03","WC-4":"3.1E-02","WT-1":"2.7E-02","WT-2":"7.7E-03","WT-3":"9.9E-03","WT-4":"8.5E-02","AC-1":"2.5E-02","AC-2":"1.9E-02","AC-3":"6.4E-03","AC-4":"2.8E-02","AT-1":"2.6E-02","AT-2":"3.1E-02","AT-3":"9.8E-03","AT-4":"8.0E-03"},{"Metabolite":"Trp","WC-1":"4.5E-01","WC-2":"2.4E-01","WC-3":"2.5E-01","WC-4":"3.7E-01","WT-1":"3.5E-01","WT-2":"2.7E-01","WT-3":"3.1E-01","WT-4":"4.5E-01","AC-1":"4.1E-01","AC-2":"3.6E-01","AC-3":"2.4E-01","AC-4":"4.3E-01","AT-1":"3.9E-01","AT-2":"4.1E-01","AT-3":"3.7E-01","AT-4":"3.3E-01"},{"Metabolite":"Tyr","WC-1":"2.2E-01","WC-2":"2.3E-01","WC-3":"2.2E-01","WC-4":"2.6E-01","WT-1":"2.9E-01","WT-2":"2.3E-01","WT-3":"2.2E-01","WT-4":"2.9E-01","AC-1":"3.5E-01","AC-2":"2.8E-01","AC-3":"2.2E-01","AC-4":"2.8E-01","AT-1":"3.4E-01","AT-2":"3.9E-01","AT-3":"3.4E-01","AT-4":"3.3E-01"},{"Metabolite":"Tyr-Glu","WC-1":"3.9E-06","WC-2":"1.3E-05","WC-3":"1.0E-05","WC-4":"4.6E-06","WT-1":"1.1E-05","WT-2":"1.3E-05","WT-3":"1.3E-05","WT-4":"N.D.","AC-1":"1.5E-05","AC-2":"9.4E-06","AC-3":"1.9E-05","AC-4":"1.1E-05","AT-1":"N.D.","AT-2":"N.D.","AT-3":"1.2E-05","AT-4":"9.1E-06"},{"Metabolite":"Tyrosine methyl ester","WC-1":"5.0E-05","WC-2":"2.1E-05","WC-3":"2.8E-05","WC-4":"3.3E-05","WT-1":"3.1E-05","WT-2":"5.0E-05","WT-3":"5.5E-05","WT-4":"8.7E-05","AC-1":"2.8E-05","AC-2":"2.3E-05","AC-3":"2.5E-05","AC-4":"4.9E-05","AT-1":"4.0E-05","AT-2":"3.2E-05","AT-3":"3.3E-05","AT-4":"2.8E-05"},{"Metabolite":"UDP","WC-1":"5.5E-05","WC-2":"5.7E-05","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"2.3E-04","AC-1":"N.D.","AC-2":"N.D.","AC-3":"1.1E-04","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"UDP-glucose　UDP-galactose","WC-1":"N.D.","WC-2":"8.5E-05","WC-3":"N.D.","WC-4":"7.3E-05","WT-1":"3.7E-05","WT-2":"3.0E-05","WT-3":"N.D.","WT-4":"1.3E-04","AC-1":"N.D.","AC-2":"N.D.","AC-3":"6.9E-05","AC-4":"N.D.","AT-1":"N.D.","AT-2":"5.7E-05","AT-3":"2.2E-05","AT-4":"N.D."},{"Metabolite":"UDP-N-acetylglucosamine　UDP-N-acetylgalactosamine","WC-1":"N.D.","WC-2":"6.2E-05","WC-3":"N.D.","WC-4":"3.5E-05","WT-1":"6.1E-05","WT-2":"N.D.","WT-3":"N.D.","WT-4":"9.6E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"7.9E-05","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"4.8E-05","AT-4":"4.3E-05"},{"Metabolite":"UMP","WC-1":"6.4E-05","WC-2":"1.0E-04","WC-3":"4.9E-05","WC-4":"7.1E-05","WT-1":"1.2E-04","WT-2":"N.D.","WT-3":"4.7E-05","WT-4":"2.9E-04","AC-1":"N.D.","AC-2":"N.D.","AC-3":"1.3E-04","AC-4":"N.D.","AT-1":"7.7E-05","AT-2":"3.0E-05","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Uracil","WC-1":"1.3E-02","WC-2":"8.9E-03","WC-3":"1.1E-02","WC-4":"1.1E-02","WT-1":"1.2E-02","WT-2":"1.4E-02","WT-3":"1.9E-02","WT-4":"2.0E-02","AC-1":"1.0E-02","AC-2":"6.9E-03","AC-3":"6.0E-03","AC-4":"1.3E-02","AT-1":"1.2E-02","AT-2":"1.5E-02","AT-3":"1.2E-02","AT-4":"1.0E-02"},{"Metabolite":"Urea","WC-1":"1.1E+00","WC-2":"1.3E+00","WC-3":"1.1E+00","WC-4":"1.2E+00","WT-1":"1.1E+00","WT-2":"1.1E+00","WT-3":"1.2E+00","WT-4":"1.5E+00","AC-1":"1.2E+00","AC-2":"1.3E+00","AC-3":"1.4E+00","AC-4":"1.5E+00","AT-1":"1.9E+00","AT-2":"1.4E+00","AT-3":"1.4E+00","AT-4":"1.4E+00"},{"Metabolite":"Ureidoglycolic acid","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"4.4E-05","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Uric acid","WC-1":"4.7E-02","WC-2":"5.9E-02","WC-3":"6.8E-02","WC-4":"4.3E-02","WT-1":"6.1E-02","WT-2":"5.8E-02","WT-3":"1.1E-01","WT-4":"7.7E-02","AC-1":"4.2E-02","AC-2":"3.8E-02","AC-3":"1.4E-02","AC-4":"5.6E-02","AT-1":"6.6E-02","AT-2":"6.8E-02","AT-3":"6.2E-02","AT-4":"4.9E-02"},{"Metabolite":"Uridine","WC-1":"1.2E-02","WC-2":"1.0E-02","WC-3":"1.4E-02","WC-4":"1.0E-02","WT-1":"1.2E-02","WT-2":"1.5E-02","WT-3":"2.5E-02","WT-4":"2.1E-02","AC-1":"1.1E-02","AC-2":"7.6E-03","AC-3":"6.2E-03","AC-4":"1.6E-02","AT-1":"1.7E-02","AT-2":"1.9E-02","AT-3":"1.6E-02","AT-4":"1.2E-02"},{"Metabolite":"Urocanic acid","WC-1":"9.2E-04","WC-2":"9.2E-04","WC-3":"5.3E-04","WC-4":"8.0E-04","WT-1":"6.7E-04","WT-2":"6.0E-04","WT-3":"3.3E-04","WT-4":"6.3E-04","AC-1":"9.9E-04","AC-2":"2.1E-03","AC-3":"1.1E-03","AC-4":"1.0E-03","AT-1":"9.2E-04","AT-2":"8.0E-04","AT-3":"1.4E-03","AT-4":"8.6E-04"},{"Metabolite":"UTP","WC-1":"5.2E-05","WC-2":"7.0E-05","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"1.7E-04","AC-1":"N.D.","AC-2":"N.D.","AC-3":"2.0E-04","AC-4":"3.4E-05","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Val","WC-1":"5.2E-01","WC-2":"4.5E-01","WC-3":"3.8E-01","WC-4":"5.2E-01","WT-1":"4.4E-01","WT-2":"3.5E-01","WT-3":"4.3E-01","WT-4":"5.5E-01","AC-1":"4.9E-01","AC-2":"4.9E-01","AC-3":"5.4E-01","AC-4":"5.6E-01","AT-1":"6.2E-01","AT-2":"4.7E-01","AT-3":"5.8E-01","AT-4":"5.6E-01"},{"Metabolite":"XA0003","WC-1":"N.D.","WC-2":"5.8E-05","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"1.4E-04","WT-3":"N.D.","WT-4":"6.4E-05","AC-1":"1.8E-04","AC-2":"3.2E-04","AC-3":"4.6E-04","AC-4":"3.8E-04","AT-1":"3.2E-04","AT-2":"4.9E-05","AT-3":"1.3E-04","AT-4":"1.8E-04"},{"Metabolite":"XA0004","WC-1":"1.1E-04","WC-2":"9.9E-05","WC-3":"9.7E-05","WC-4":"1.1E-04","WT-1":"1.5E-04","WT-2":"1.0E-04","WT-3":"1.3E-04","WT-4":"1.7E-04","AC-1":"1.0E-04","AC-2":"1.8E-04","AC-3":"2.0E-04","AC-4":"1.3E-04","AT-1":"1.8E-04","AT-2":"1.5E-04","AT-3":"1.3E-04","AT-4":"1.4E-04"},{"Metabolite":"XA0012","WC-1":"1.7E-03","WC-2":"1.2E-03","WC-3":"1.9E-03","WC-4":"1.2E-03","WT-1":"1.7E-03","WT-2":"1.6E-03","WT-3":"2.7E-03","WT-4":"3.1E-03","AC-1":"2.3E-03","AC-2":"1.3E-03","AC-3":"1.5E-03","AC-4":"2.2E-03","AT-1":"3.9E-03","AT-2":"2.5E-03","AT-3":"2.8E-03","AT-4":"2.0E-03"},{"Metabolite":"XA0013","WC-1":"1.6E-02","WC-2":"7.2E-03","WC-3":"9.0E-03","WC-4":"1.2E-02","WT-1":"9.4E-03","WT-2":"4.9E-03","WT-3":"7.3E-03","WT-4":"1.4E-02","AC-1":"6.6E-03","AC-2":"7.8E-03","AC-3":"8.0E-03","AC-4":"5.9E-03","AT-1":"1.2E-02","AT-2":"1.3E-02","AT-3":"6.1E-03","AT-4":"6.2E-03"},{"Metabolite":"XA0017","WC-1":"1.0E-04","WC-2":"1.1E-04","WC-3":"1.8E-04","WC-4":"N.D.","WT-1":"2.0E-04","WT-2":"1.1E-04","WT-3":"4.7E-04","WT-4":"1.4E-04","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"2.4E-04","AT-2":"1.6E-04","AT-3":"2.7E-04","AT-4":"2.0E-04"},{"Metabolite":"XA0019","WC-1":"8.9E-04","WC-2":"1.1E-03","WC-3":"1.7E-03","WC-4":"9.6E-04","WT-1":"1.1E-03","WT-2":"1.1E-03","WT-3":"1.4E-03","WT-4":"9.4E-04","AC-1":"1.9E-03","AC-2":"1.2E-03","AC-3":"9.9E-04","AC-4":"1.2E-03","AT-1":"1.4E-03","AT-2":"1.1E-03","AT-3":"8.4E-04","AT-4":"8.9E-04"},{"Metabolite":"XA0027","WC-1":"1.9E-03","WC-2":"2.9E-03","WC-3":"2.9E-03","WC-4":"1.9E-03","WT-1":"2.8E-03","WT-2":"3.2E-03","WT-3":"3.2E-03","WT-4":"3.0E-03","AC-1":"2.1E-03","AC-2":"3.2E-03","AC-3":"3.7E-03","AC-4":"3.6E-03","AT-1":"3.4E-03","AT-2":"4.2E-03","AT-3":"2.7E-03","AT-4":"3.7E-03"},{"Metabolite":"XA0035","WC-1":"4.6E-03","WC-2":"2.6E-03","WC-3":"3.2E-03","WC-4":"4.3E-03","WT-1":"2.9E-03","WT-2":"2.0E-03","WT-3":"2.9E-03","WT-4":"6.1E-03","AC-1":"4.3E-03","AC-2":"3.2E-03","AC-3":"1.2E-03","AC-4":"5.7E-03","AT-1":"3.7E-03","AT-2":"4.4E-03","AT-3":"2.5E-03","AT-4":"1.9E-03"},{"Metabolite":"Xanthine","WC-1":"N.D.","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"5.2E-06","WT-4":"N.D.","AC-1":"N.D.","AC-2":"1.3E-05","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"N.D.","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"Xanthosine","WC-1":"1.7E-04","WC-2":"6.1E-04","WC-3":"4.3E-04","WC-4":"1.9E-04","WT-1":"2.3E-04","WT-2":"3.8E-04","WT-3":"1.1E-03","WT-4":"5.3E-04","AC-1":"1.7E-04","AC-2":"2.5E-04","AC-3":"N.D.","AC-4":"4.4E-04","AT-1":"3.2E-04","AT-2":"2.5E-04","AT-3":"3.4E-04","AT-4":"9.2E-05"},{"Metabolite":"Xanthurenic acid","WC-1":"6.4E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"4.7E-05","WT-2":"N.D.","WT-3":"N.D.","WT-4":"9.6E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"5.7E-05","AT-2":"N.D.","AT-3":"7.6E-05","AT-4":"6.0E-05"},{"Metabolite":"XC0016","WC-1":"2.6E-03","WC-2":"2.5E-03","WC-3":"3.2E-03","WC-4":"2.7E-03","WT-1":"2.5E-03","WT-2":"2.7E-03","WT-3":"3.0E-03","WT-4":"3.0E-03","AC-1":"3.1E-03","AC-2":"3.5E-03","AC-3":"2.6E-03","AC-4":"3.7E-03","AT-1":"4.6E-03","AT-2":"3.4E-03","AT-3":"3.6E-03","AT-4":"3.1E-03"},{"Metabolite":"XC0017","WC-1":"7.7E-06","WC-2":"N.D.","WC-3":"N.D.","WC-4":"1.2E-05","WT-1":"7.5E-06","WT-2":"N.D.","WT-3":"N.D.","WT-4":"8.5E-06","AC-1":"1.1E-05","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"1.0E-05","AT-2":"9.9E-06","AT-3":"1.3E-05","AT-4":"1.2E-05"},{"Metabolite":"XC0029","WC-1":"2.4E-04","WC-2":"3.1E-04","WC-3":"3.0E-04","WC-4":"2.4E-04","WT-1":"2.3E-04","WT-2":"2.5E-04","WT-3":"3.7E-04","WT-4":"3.1E-04","AC-1":"2.4E-04","AC-2":"2.5E-04","AC-3":"2.9E-04","AC-4":"2.5E-04","AT-1":"3.6E-04","AT-2":"3.4E-04","AT-3":"3.2E-04","AT-4":"N.D."},{"Metabolite":"XC0040","WC-1":"1.0E-03","WC-2":"1.2E-03","WC-3":"8.5E-04","WC-4":"1.3E-03","WT-1":"1.6E-03","WT-2":"1.4E-03","WT-3":"1.8E-03","WT-4":"2.4E-03","AC-1":"8.9E-04","AC-2":"1.2E-03","AC-3":"9.0E-04","AC-4":"1.1E-03","AT-1":"1.7E-03","AT-2":"1.5E-03","AT-3":"1.4E-03","AT-4":"1.1E-03"},{"Metabolite":"XC0061　Propionylcarnitine","WC-1":"8.3E-03","WC-2":"5.2E-03","WC-3":"4.8E-03","WC-4":"9.4E-03","WT-1":"1.4E-02","WT-2":"9.8E-03","WT-3":"1.0E-02","WT-4":"1.8E-02","AC-1":"8.9E-03","AC-2":"7.7E-03","AC-3":"4.8E-03","AC-4":"1.0E-02","AT-1":"1.0E-02","AT-2":"1.1E-02","AT-3":"1.1E-02","AT-4":"1.0E-02"},{"Metabolite":"XC0065","WC-1":"3.9E-04","WC-2":"1.9E-04","WC-3":"1.7E-04","WC-4":"3.8E-04","WT-1":"2.3E-04","WT-2":"2.3E-04","WT-3":"1.9E-04","WT-4":"4.4E-04","AC-1":"4.0E-04","AC-2":"4.2E-04","AC-3":"2.6E-04","AC-4":"4.5E-04","AT-1":"3.5E-04","AT-2":"4.2E-04","AT-3":"3.2E-04","AT-4":"3.6E-04"},{"Metabolite":"XC0071","WC-1":"1.1E-04","WC-2":"1.1E-04","WC-3":"9.3E-05","WC-4":"7.9E-05","WT-1":"1.6E-04","WT-2":"1.3E-04","WT-3":"1.6E-04","WT-4":"2.0E-04","AC-1":"1.0E-04","AC-2":"9.9E-05","AC-3":"1.1E-04","AC-4":"9.8E-05","AT-1":"1.7E-04","AT-2":"1.7E-04","AT-3":"1.7E-04","AT-4":"1.3E-04"},{"Metabolite":"XC0089　Nicotinamide riboside","WC-1":"4.4E-05","WC-2":"3.8E-05","WC-3":"5.6E-05","WC-4":"4.1E-05","WT-1":"3.6E-05","WT-2":"3.5E-05","WT-3":"5.5E-05","WT-4":"5.0E-05","AC-1":"2.8E-05","AC-2":"2.9E-05","AC-3":"2.8E-05","AC-4":"4.4E-05","AT-1":"6.3E-05","AT-2":"5.8E-05","AT-3":"7.2E-05","AT-4":"5.2E-05"},{"Metabolite":"XC0120","WC-1":"1.5E-04","WC-2":"3.2E-04","WC-3":"5.5E-04","WC-4":"1.7E-04","WT-1":"2.6E-04","WT-2":"2.8E-04","WT-3":"2.5E-04","WT-4":"2.2E-04","AC-1":"1.8E-04","AC-2":"2.0E-04","AC-3":"4.1E-04","AC-4":"2.3E-04","AT-1":"2.6E-04","AT-2":"1.8E-04","AT-3":"3.0E-04","AT-4":"4.4E-04"},{"Metabolite":"XC0126","WC-1":"7.2E-05","WC-2":"1.1E-04","WC-3":"1.1E-04","WC-4":"8.1E-05","WT-1":"9.3E-05","WT-2":"1.0E-04","WT-3":"8.4E-05","WT-4":"1.5E-04","AC-1":"9.1E-05","AC-2":"1.3E-04","AC-3":"1.3E-04","AC-4":"1.3E-04","AT-1":"1.5E-04","AT-2":"1.4E-04","AT-3":"2.1E-04","AT-4":"1.3E-04"},{"Metabolite":"XC0132","WC-1":"1.6E-04","WC-2":"2.4E-04","WC-3":"2.3E-04","WC-4":"1.4E-04","WT-1":"1.7E-04","WT-2":"2.3E-04","WT-3":"1.9E-04","WT-4":"2.1E-04","AC-1":"1.9E-04","AC-2":"2.2E-04","AC-3":"3.7E-04","AC-4":"2.4E-04","AT-1":"2.8E-04","AT-2":"2.0E-04","AT-3":"2.1E-04","AT-4":"2.5E-04"},{"Metabolite":"XC0145","WC-1":"4.1E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"9.4E-05","WT-1":"6.2E-05","WT-2":"N.D.","WT-3":"3.1E-05","WT-4":"7.8E-05","AC-1":"4.7E-05","AC-2":"7.6E-05","AC-3":"6.0E-05","AC-4":"N.D.","AT-1":"8.3E-05","AT-2":"9.8E-05","AT-3":"5.9E-05","AT-4":"6.8E-05"},{"Metabolite":"XC0146","WC-1":"2.1E-05","WC-2":"3.8E-05","WC-3":"3.5E-05","WC-4":"1.7E-05","WT-1":"1.8E-05","WT-2":"3.2E-05","WT-3":"2.5E-05","WT-4":"1.6E-05","AC-1":"2.6E-05","AC-2":"2.7E-05","AC-3":"6.6E-05","AC-4":"3.5E-05","AT-1":"3.5E-05","AT-2":"3.5E-05","AT-3":"N.D.","AT-4":"3.5E-05"},{"Metabolite":"XC0150","WC-1":"1.8E-04","WC-2":"1.7E-04","WC-3":"2.2E-04","WC-4":"1.5E-04","WT-1":"1.6E-04","WT-2":"1.8E-04","WT-3":"1.9E-04","WT-4":"1.7E-04","AC-1":"2.0E-04","AC-2":"2.0E-04","AC-3":"1.7E-04","AC-4":"1.9E-04","AT-1":"1.7E-04","AT-2":"1.6E-04","AT-3":"2.1E-04","AT-4":"2.0E-04"},{"Metabolite":"Xylulose 5-phosphate","WC-1":"6.8E-05","WC-2":"9.5E-05","WC-3":"1.2E-04","WC-4":"1.0E-04","WT-1":"1.1E-04","WT-2":"N.D.","WT-3":"1.6E-04","WT-4":"2.5E-04","AC-1":"N.D.","AC-2":"9.0E-05","AC-3":"6.5E-05","AC-4":"1.1E-04","AT-1":"1.8E-04","AT-2":"1.3E-04","AT-3":"1.2E-04","AT-4":"1.0E-04"},{"Metabolite":"β-Ala","WC-1":"6.2E-04","WC-2":"1.1E-03","WC-3":"1.5E-03","WC-4":"5.2E-04","WT-1":"1.3E-03","WT-2":"1.5E-03","WT-3":"1.6E-03","WT-4":"1.0E-03","AC-1":"6.6E-04","AC-2":"9.7E-04","AC-3":"1.8E-03","AC-4":"6.6E-04","AT-1":"1.4E-03","AT-2":"1.1E-03","AT-3":"1.7E-03","AT-4":"2.0E-03"},{"Metabolite":"β-Ala-Lys","WC-1":"1.1E-05","WC-2":"6.9E-06","WC-3":"1.3E-05","WC-4":"1.5E-05","WT-1":"1.1E-05","WT-2":"1.1E-05","WT-3":"8.8E-06","WT-4":"6.2E-06","AC-1":"1.0E-05","AC-2":"1.2E-05","AC-3":"2.8E-05","AC-4":"5.1E-06","AT-1":"1.2E-05","AT-2":"1.3E-05","AT-3":"9.2E-06","AT-4":"1.0E-05"},{"Metabolite":"β-Tyr","WC-1":"4.5E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"6.3E-05","WT-1":"5.1E-05","WT-2":"4.5E-05","WT-3":"4.9E-05","WT-4":"N.D.","AC-1":"5.9E-05","AC-2":"4.9E-05","AC-3":"N.D.","AC-4":"N.D.","AT-1":"4.8E-05","AT-2":"N.D.","AT-3":"5.2E-05","AT-4":"N.D."},{"Metabolite":"γ-Butyrobetaine","WC-1":"1.0E-02","WC-2":"6.0E-03","WC-3":"5.2E-03","WC-4":"9.0E-03","WT-1":"1.0E-02","WT-2":"8.6E-03","WT-3":"9.8E-03","WT-4":"1.5E-02","AC-1":"1.3E-02","AC-2":"1.1E-02","AC-3":"6.8E-03","AC-4":"1.4E-02","AT-1":"1.3E-02","AT-2":"1.4E-02","AT-3":"1.1E-02","AT-4":"1.3E-02"},{"Metabolite":"γ-Glu-Ala","WC-1":"5.2E-03","WC-2":"6.0E-03","WC-3":"6.6E-03","WC-4":"4.5E-03","WT-1":"5.8E-03","WT-2":"6.4E-03","WT-3":"5.6E-03","WT-4":"4.7E-03","AC-1":"7.8E-03","AC-2":"6.9E-03","AC-3":"5.8E-03","AC-4":"4.9E-03","AT-1":"7.4E-03","AT-2":"5.7E-03","AT-3":"6.7E-03","AT-4":"6.8E-03"},{"Metabolite":"γ-Glu-Arg_divalent","WC-1":"3.8E-03","WC-2":"4.6E-03","WC-3":"4.4E-03","WC-4":"4.3E-03","WT-1":"6.2E-03","WT-2":"5.0E-03","WT-3":"7.5E-03","WT-4":"5.0E-03","AC-1":"3.6E-03","AC-2":"4.8E-03","AC-3":"6.2E-03","AC-4":"5.0E-03","AT-1":"7.8E-03","AT-2":"5.8E-03","AT-3":"6.0E-03","AT-4":"5.0E-03"},{"Metabolite":"γ-Glu-Asn","WC-1":"8.1E-04","WC-2":"1.0E-03","WC-3":"1.1E-03","WC-4":"7.8E-04","WT-1":"1.4E-03","WT-2":"1.6E-03","WT-3":"1.1E-03","WT-4":"7.9E-04","AC-1":"1.8E-03","AC-2":"1.3E-03","AC-3":"1.0E-03","AC-4":"8.4E-04","AT-1":"1.4E-03","AT-2":"1.4E-03","AT-3":"2.1E-03","AT-4":"1.8E-03"},{"Metabolite":"γ-Glu-Asp","WC-1":"3.0E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"3.4E-05","WT-1":"N.D.","WT-2":"2.9E-05","WT-3":"3.1E-05","WT-4":"N.D.","AC-1":"3.5E-05","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"4.1E-05","AT-3":"3.9E-05","AT-4":"N.D."},{"Metabolite":"γ-Glu-Citrulline","WC-1":"1.9E-03","WC-2":"1.2E-03","WC-3":"2.1E-03","WC-4":"1.7E-03","WT-1":"2.1E-03","WT-2":"2.2E-03","WT-3":"2.4E-03","WT-4":"2.1E-03","AC-1":"1.7E-03","AC-2":"1.5E-03","AC-3":"1.0E-03","AC-4":"1.7E-03","AT-1":"2.3E-03","AT-2":"2.2E-03","AT-3":"2.3E-03","AT-4":"1.7E-03"},{"Metabolite":"γ-Glu-Gln","WC-1":"2.9E-02","WC-2":"2.3E-02","WC-3":"3.4E-02","WC-4":"2.3E-02","WT-1":"3.9E-02","WT-2":"3.9E-02","WT-3":"3.9E-02","WT-4":"2.4E-02","AC-1":"3.4E-02","AC-2":"N.D.","AC-3":"2.4E-02","AC-4":"3.1E-02","AT-1":"4.0E-02","AT-2":"4.0E-02","AT-3":"4.1E-02","AT-4":"4.3E-02"},{"Metabolite":"γ-Glu-Glu","WC-1":"5.6E-04","WC-2":"1.0E-03","WC-3":"1.4E-03","WC-4":"5.9E-04","WT-1":"1.8E-03","WT-2":"1.7E-03","WT-3":"2.0E-03","WT-4":"8.7E-04","AC-1":"1.0E-03","AC-2":"9.0E-04","AC-3":"8.9E-04","AC-4":"7.4E-04","AT-1":"1.7E-03","AT-2":"1.3E-03","AT-3":"1.5E-03","AT-4":"1.5E-03"},{"Metabolite":"γ-Glu-Gly","WC-1":"4.9E-03","WC-2":"8.1E-03","WC-3":"9.0E-03","WC-4":"4.5E-03","WT-1":"7.8E-03","WT-2":"9.2E-03","WT-3":"9.1E-03","WT-4":"4.7E-03","AC-1":"7.5E-03","AC-2":"8.3E-03","AC-3":"6.8E-03","AC-4":"6.3E-03","AT-1":"1.1E-02","AT-2":"8.5E-03","AT-3":"1.0E-02","AT-4":"1.0E-02"},{"Metabolite":"γ-Glu-His","WC-1":"5.2E-04","WC-2":"6.2E-04","WC-3":"6.5E-04","WC-4":"5.0E-04","WT-1":"8.4E-04","WT-2":"9.3E-04","WT-3":"9.5E-04","WT-4":"7.0E-04","AC-1":"1.0E-03","AC-2":"8.1E-04","AC-3":"7.8E-04","AC-4":"7.3E-04","AT-1":"9.4E-04","AT-2":"8.6E-04","AT-3":"1.1E-03","AT-4":"1.2E-03"},{"Metabolite":"γ-Glu-Ile　γ-Glu-Leu","WC-1":"4.8E-03","WC-2":"7.2E-03","WC-3":"7.0E-03","WC-4":"5.3E-03","WT-1":"7.2E-03","WT-2":"7.5E-03","WT-3":"8.8E-03","WT-4":"6.3E-03","AC-1":"6.1E-03","AC-2":"7.9E-03","AC-3":"8.4E-03","AC-4":"6.1E-03","AT-1":"1.1E-02","AT-2":"6.4E-03","AT-3":"8.6E-03","AT-4":"8.4E-03"},{"Metabolite":"γ-Glu-Lys_divalent","WC-1":"5.5E-03","WC-2":"6.2E-03","WC-3":"6.4E-03","WC-4":"5.8E-03","WT-1":"7.1E-03","WT-2":"6.4E-03","WT-3":"8.7E-03","WT-4":"6.6E-03","AC-1":"5.5E-03","AC-2":"6.8E-03","AC-3":"8.4E-03","AC-4":"7.1E-03","AT-1":"1.1E-02","AT-2":"8.3E-03","AT-3":"7.2E-03","AT-4":"7.2E-03"},{"Metabolite":"γ-Glu-Met","WC-1":"2.5E-03","WC-2":"3.0E-03","WC-3":"2.4E-03","WC-4":"2.4E-03","WT-1":"4.0E-03","WT-2":"3.2E-03","WT-3":"3.5E-03","WT-4":"2.8E-03","AC-1":"2.9E-03","AC-2":"3.0E-03","AC-3":"2.9E-03","AC-4":"2.6E-03","AT-1":"4.7E-03","AT-2":"3.4E-03","AT-3":"2.9E-03","AT-4":"3.8E-03"},{"Metabolite":"γ-Glu-Ornitine","WC-1":"6.2E-04","WC-2":"N.D.","WC-3":"N.D.","WC-4":"6.4E-04","WT-1":"N.D.","WT-2":"7.4E-04","WT-3":"1.1E-03","WT-4":"N.D.","AC-1":"6.8E-04","AC-2":"7.8E-04","AC-3":"N.D.","AC-4":"N.D.","AT-1":"1.1E-03","AT-2":"N.D.","AT-3":"1.2E-03","AT-4":"9.3E-04"},{"Metabolite":"γ-Glu-Phe","WC-1":"2.0E-03","WC-2":"2.7E-03","WC-3":"2.3E-03","WC-4":"2.4E-03","WT-1":"3.5E-03","WT-2":"3.6E-03","WT-3":"3.1E-03","WT-4":"2.5E-03","AC-1":"3.4E-03","AC-2":"3.1E-03","AC-3":"3.3E-03","AC-4":"2.4E-03","AT-1":"3.7E-03","AT-2":"3.0E-03","AT-3":"4.1E-03","AT-4":"3.2E-03"},{"Metabolite":"γ-Glu-Ser","WC-1":"2.5E-03","WC-2":"3.0E-03","WC-3":"3.6E-03","WC-4":"2.6E-03","WT-1":"3.7E-03","WT-2":"3.7E-03","WT-3":"3.3E-03","WT-4":"2.9E-03","AC-1":"3.7E-03","AC-2":"3.9E-03","AC-3":"2.9E-03","AC-4":"3.2E-03","AT-1":"4.3E-03","AT-2":"3.7E-03","AT-3":"4.3E-03","AT-4":"4.0E-03"},{"Metabolite":"γ-Glu-Taurine","WC-1":"2.2E-04","WC-2":"3.7E-04","WC-3":"3.8E-04","WC-4":"2.2E-04","WT-1":"2.5E-04","WT-2":"2.8E-04","WT-3":"3.6E-04","WT-4":"2.2E-04","AC-1":"2.8E-04","AC-2":"3.6E-04","AC-3":"3.9E-04","AC-4":"2.3E-04","AT-1":"4.7E-04","AT-2":"3.7E-04","AT-3":"3.7E-04","AT-4":"3.6E-04"},{"Metabolite":"γ-Glu-Thr","WC-1":"2.0E-03","WC-2":"2.5E-03","WC-3":"2.8E-03","WC-4":"1.9E-03","WT-1":"3.1E-03","WT-2":"2.7E-03","WT-3":"3.4E-03","WT-4":"2.4E-03","AC-1":"1.9E-03","AC-2":"2.5E-03","AC-3":"2.8E-03","AC-4":"2.0E-03","AT-1":"4.1E-03","AT-2":"2.6E-03","AT-3":"2.9E-03","AT-4":"2.6E-03"},{"Metabolite":"γ-Glu-Trp","WC-1":"6.9E-04","WC-2":"3.8E-04","WC-3":"4.3E-04","WC-4":"6.2E-04","WT-1":"8.8E-04","WT-2":"9.1E-04","WT-3":"8.2E-04","WT-4":"8.4E-04","AC-1":"9.1E-04","AC-2":"6.7E-04","AC-3":"5.7E-04","AC-4":"6.7E-04","AT-1":"9.4E-04","AT-2":"9.5E-04","AT-3":"9.1E-04","AT-4":"8.5E-04"},{"Metabolite":"γ-Glu-Tyr","WC-1":"1.6E-03","WC-2":"2.0E-03","WC-3":"2.1E-03","WC-4":"1.8E-03","WT-1":"3.5E-03","WT-2":"3.3E-03","WT-3":"2.8E-03","WT-4":"2.4E-03","AC-1":"2.8E-03","AC-2":"2.5E-03","AC-3":"1.9E-03","AC-4":"1.7E-03","AT-1":"3.5E-03","AT-2":"4.1E-03","AT-3":"3.9E-03","AT-4":"3.5E-03"},{"Metabolite":"γ-Glu-Val","WC-1":"1.9E-03","WC-2":"3.2E-03","WC-3":"4.1E-03","WC-4":"1.9E-03","WT-1":"3.4E-03","WT-2":"3.8E-03","WT-3":"4.5E-03","WT-4":"3.0E-03","AC-1":"2.2E-03","AC-2":"2.7E-03","AC-3":"3.1E-03","AC-4":"2.2E-03","AT-1":"4.8E-03","AT-2":"3.3E-03","AT-3":"4.3E-03","AT-4":"4.3E-03"},{"Metabolite":"γ-Glu-Val-Gly","WC-1":"2.9E-04","WC-2":"5.5E-04","WC-3":"4.9E-04","WC-4":"3.4E-04","WT-1":"3.7E-04","WT-2":"4.3E-04","WT-3":"4.3E-04","WT-4":"3.4E-04","AC-1":"2.8E-04","AC-2":"3.9E-04","AC-3":"6.6E-04","AC-4":"3.9E-04","AT-1":"5.2E-04","AT-2":"4.3E-04","AT-3":"4.1E-04","AT-4":"4.3E-04"}],

"Metabolites":[{"Metabolite":"1-Methyl-4-imidazoleacetic acid","PubChem CID":"75810","HMDB ID":"HMDB0002820","m/z":"141.0658075","MT/RT":"8.096480063"},{"Metabolite":"1-Methyladenosine","PubChem CID":"27476","HMDB ID":"HMDB0003331","m/z":"282.119585","MT/RT":"9.830511406"},{"Metabolite":"1-Methylhistamine","PubChem CID":"3614","HMDB ID":"HMDB0000898","m/z":"126.1025869","MT/RT":"4.849746413"},{"Metabolite":"1-Methylhydantoin　Glycine anhydride","PubChem CID":"69217　7817","HMDB ID":"HMDB0003646","m/z":"115.0501956","MT/RT":"23.16278713"},{"Metabolite":"1-Methylnicotinamide","PubChem CID":"457","HMDB ID":"HMDB0000699","m/z":"137.0709425","MT/RT":"7.219635281"},{"Metabolite":"1-Methyluric acid","PubChem CID":"69726","HMDB ID":"HMDB0003099","m/z":"181.0366979","MT/RT":"8.799360786"},{"Metabolite":"10-Hydroxydecanoic acid","PubChem CID":"74300","HMDB ID":"","m/z":"187.1339347","MT/RT":"7.9429911"},{"Metabolite":"11-Aminoundecanoic acid","PubChem CID":"17083","HMDB ID":"","m/z":"202.1799669","MT/RT":"9.538712938"},{"Metabolite":"1H-Imidazole-4-propionic acid","PubChem CID":"10105257","HMDB ID":"","m/z":"141.0658325","MT/RT":"7.959853956"},{"Metabolite":"2'-Deoxyadenosine　5'-Deoxyadenosine","PubChem CID":"13730　439182","HMDB ID":"HMDB0000101　HMDB0001983","m/z":"252.1090725","MT/RT":"9.5635055"},{"Metabolite":"2'-Deoxycytidine","PubChem CID":"13711","HMDB ID":"HMDB0000014","m/z":"228.0978188","MT/RT":"9.295052719"},{"Metabolite":"2'-Deoxyuridine","PubChem CID":"13712","HMDB ID":"HMDB0000012","m/z":"229.081584","MT/RT":"23.21180233"},{"Metabolite":"2,3-Diphosphoglyceric acid","PubChem CID":"186004","HMDB ID":"HMDB0001294","m/z":"264.9519375","MT/RT":"18.84753488"},{"Metabolite":"2,5-Dihydroxybenzoic acid","PubChem CID":"3469","HMDB ID":"HMDB0000152","m/z":"153.0193329","MT/RT":"9.773322107"},{"Metabolite":"2,6-Diaminopimelic acid","PubChem CID":"439283","HMDB ID":"HMDB0001370","m/z":"191.1022863","MT/RT":"8.718115781"},{"Metabolite":"2-(Creatinine-3-yl)propionic acid","PubChem CID":"","HMDB ID":"","m/z":"186.0873564","MT/RT":"11.04588343"},{"Metabolite":"2-Amino-2-(hydroxymethyl)-1,3-propanediol","PubChem CID":"6503","HMDB ID":"","m/z":"122.08114","MT/RT":"8.165601938"},{"Metabolite":"2-Aminoadipic acid　O-Acetylhomoserine","PubChem CID":"92136　439389","HMDB ID":"HMDB0000510","m/z":"162.07602","MT/RT":"10.8579635"},{"Metabolite":"2-Aminobutyric acid　2-Aminoisobutyric acid","PubChem CID":"6657　6119","HMDB ID":"HMDB0000452　HMDB0001906","m/z":"104.0705398","MT/RT":"9.502520063"},{"Metabolite":"2-Hydroxy-4-methylvaleric acid","PubChem CID":"439960","HMDB ID":"HMDB0000624","m/z":"131.0713125","MT/RT":"9.003092406"},{"Metabolite":"2-Hydroxybutyric acid","PubChem CID":"440864","HMDB ID":"HMDB0000008","m/z":"103.0400625","MT/RT":"9.958359188"},{"Metabolite":"2-Hydroxyoctanoic acid","PubChem CID":"94180","HMDB ID":"HMDB0000711","m/z":"159.1026","MT/RT":"8.429587938"},{"Metabolite":"2-Hydroxyvaleric acid","PubChem CID":"98009","HMDB ID":"HMDB0001863","m/z":"117.0557005","MT/RT":"9.412241875"},{"Metabolite":"2-Isopropylmalic acid","PubChem CID":"5280523","HMDB ID":"HMDB0000402","m/z":"175.06116","MT/RT":"14.050829"},{"Metabolite":"2-Methylserine","PubChem CID":"439656","HMDB ID":"","m/z":"120.06552","MT/RT":"10.24230275"},{"Metabolite":"2-Oxoglutaric acid","PubChem CID":"51","HMDB ID":"HMDB0000208","m/z":"145.0142194","MT/RT":"21.95389238"},{"Metabolite":"2-Oxoisovaleric acid","PubChem CID":"49","HMDB ID":"HMDB0000019","m/z":"115.0400309","MT/RT":"10.40173894"},{"Metabolite":"3-(4-Hydroxyphenyl)propionic acid　3-(3-Hydroxyphenyl)propionic acid　2-(4-Hydroxyphenyl)propionic acid","PubChem CID":"10394　91　102526","HMDB ID":"HMDB0002199　HMDB0000375　HMDB0041683","m/z":"165.0555336","MT/RT":"8.530457182"},{"Metabolite":"3-Amino-2-piperidone","PubChem CID":"5200225","HMDB ID":"HMDB0000323","m/z":"115.0866266","MT/RT":"7.469598119"},{"Metabolite":"3-Aminobutyric acid","PubChem CID":"10932","HMDB ID":"","m/z":"104.0705456","MT/RT":"7.814549529"},{"Metabolite":"3-Guanidinopropionic acid","PubChem CID":"67701","HMDB ID":"","m/z":"132.0767523","MT/RT":"7.867224269"},{"Metabolite":"3-Hydroxy-2-methyl-4-pyrone","PubChem CID":"8369","HMDB ID":"HMDB0030776","m/z":"127.03891","MT/RT":"23.23937113"},{"Metabolite":"3-Hydroxy-3-methylglutaric acid","PubChem CID":"1662","HMDB ID":"","m/z":"161.0454933","MT/RT":"15.59241993"},{"Metabolite":"3-Hydroxybutyric acid","PubChem CID":"441","HMDB ID":"HMDB0000011,HMDB0000357,HMDB0000442","m/z":"103.0400393","MT/RT":"9.71990725"},{"Metabolite":"3-Hydroxykynurenine","PubChem CID":"11811","HMDB ID":"HMDB0011631","m/z":"225.086925","MT/RT":"9.596541906"},{"Metabolite":"3-Indoxylsulfuric acid","PubChem CID":"10258","HMDB ID":"HMDB0000682","m/z":"212.0022775","MT/RT":"9.755282344"},{"Metabolite":"3-Methoxytyrosine","PubChem CID":"1670","HMDB ID":"HMDB0001434","m/z":"212.0916669","MT/RT":"11.70791638"},{"Metabolite":"3-Methyladenine","PubChem CID":"1673","HMDB ID":"HMDB0011600","m/z":"150.077452","MT/RT":"7.785823467"},{"Metabolite":"3-Methylhistamine","PubChem CID":"69520","HMDB ID":"HMDB0001861","m/z":"126.1025019","MT/RT":"4.772093769"},{"Metabolite":"3-Methylhistidine　1-Methylhistidine","PubChem CID":"64969　92105","HMDB ID":"HMDB0000479　HMDB0000001","m/z":"170.0923313","MT/RT":"7.348653869"},{"Metabolite":"3-Phenylpropionic acid","PubChem CID":"107","HMDB ID":"HMDB0000764","m/z":"149.0607763","MT/RT":"8.933338313"},{"Metabolite":"3-Phosphoglyceric acid","PubChem CID":"439183","HMDB ID":"HMDB0000807","m/z":"184.985628","MT/RT":"20.04578767"},{"Metabolite":"3-Ureidopropionic acid","PubChem CID":"111","HMDB ID":"HMDB0000026","m/z":"131.0461775","MT/RT":"9.43033125"},{"Metabolite":"4-(β-Acetylaminoethyl)imidazole","PubChem CID":"69602","HMDB ID":"","m/z":"154.0974656","MT/RT":"8.295240389"},{"Metabolite":"4-Acetamidobutanoic acid","PubChem CID":"18189","HMDB ID":"HMDB0003681","m/z":"144.066565","MT/RT":"8.768666781"},{"Metabolite":"4-Aminohippuric acid","PubChem CID":"2148","HMDB ID":"HMDB0001867","m/z":"195.0765613","MT/RT":"9.940759375"},{"Metabolite":"4-Guanidinobutyric acid","PubChem CID":"500","HMDB ID":"HMDB0003464","m/z":"146.0924294","MT/RT":"8.141832813"},{"Metabolite":"4-Hydroxy-3-methoxyphenylglycol sulfate","PubChem CID":"3035420","HMDB ID":"HMDB0003332","m/z":"263.0230229","MT/RT":"8.217468821"},{"Metabolite":"4-Methyl-2-oxovaleric acid　3-Methyl-2-oxovaleric acid　2-Oxohexanoic acid","PubChem CID":"70　47　159664","HMDB ID":"HMDB0000695　HMDB0000491　HMDB0001864","m/z":"129.055765","MT/RT":"9.752549625"},{"Metabolite":"4-Methyl-5-thiazoleethanol","PubChem CID":"1136","HMDB ID":"","m/z":"144.047782","MT/RT":"7.88984188"},{"Metabolite":"4-Oxopyrrolidine-2-carboxylic acid","PubChem CID":"107541","HMDB ID":"","m/z":"130.0498425","MT/RT":"10.83526313"},{"Metabolite":"4-Pyridoxic acid","PubChem CID":"6723","HMDB ID":"HMDB0000017","m/z":"182.0458853","MT/RT":"8.915322433"},{"Metabolite":"5'-Deoxy-5'-methylthioadenosine","PubChem CID":"439176","HMDB ID":"HMDB0001173","m/z":"298.0966881","MT/RT":"9.952097188"},{"Metabolite":"5-Amino-4-oxovaleric acid","PubChem CID":"137","HMDB ID":"HMDB0001149","m/z":"132.0655356","MT/RT":"7.8550992"},{"Metabolite":"5-Aminoindole","PubChem CID":"78867","HMDB ID":"","m/z":"133.0759786","MT/RT":"7.6364246"},{"Metabolite":"5-Aminovaleric acid","PubChem CID":"138","HMDB ID":"HMDB0003355","m/z":"118.086365","MT/RT":"7.8504486"},{"Metabolite":"5-Hydroxyindoleacetic acid","PubChem CID":"1826","HMDB ID":"HMDB0000763","m/z":"190.05093","MT/RT":"8.3848016"},{"Metabolite":"5-Hydroxylysine","PubChem CID":"3032849","HMDB ID":"HMDB0000450","m/z":"163.107575","MT/RT":"7.020978481"},{"Metabolite":"5-Hydroxypentanoic acid","PubChem CID":"25945","HMDB ID":"HMDB0061927","m/z":"117.0557057","MT/RT":"9.094284286"},{"Metabolite":"5-Methoxyindoleacetic acid　Indole-3-lactic acid","PubChem CID":"18986　676157","HMDB ID":"HMDB0004096　HMDB0000671","m/z":"204.0664669","MT/RT":"8.379430938"},{"Metabolite":"5-Methyl-2'-deoxycytidine","PubChem CID":"440055","HMDB ID":"HMDB0002224","m/z":"242.1135013","MT/RT":"9.631654813"},{"Metabolite":"5-Methylcytosine","PubChem CID":"65040","HMDB ID":"HMDB0002894","m/z":"126.0662208","MT/RT":"7.659202513"},{"Metabolite":"5-Oxoproline","PubChem CID":"7405","HMDB ID":"HMDB0000267","m/z":"128.0352913","MT/RT":"9.682015563"},{"Metabolite":"6-Aminohexanoic acid","PubChem CID":"564","HMDB ID":"HMDB0001901","m/z":"132.101865","MT/RT":"8.176418"},{"Metabolite":"6-Hydroxyhexanoic acid","PubChem CID":"14490","HMDB ID":"","m/z":"131.071302","MT/RT":"8.785313933"},{"Metabolite":"6-Phosphogluconic acid","PubChem CID":"91493","HMDB ID":"HMDB0001316","m/z":"275.0173367","MT/RT":"14.84879233"},{"Metabolite":"7,8-Dihydrobiopterin","PubChem CID":"119055","HMDB ID":"HMDB0000038","m/z":"240.109035","MT/RT":"10.8725705"},{"Metabolite":"7-Methylguanine","PubChem CID":"11361","HMDB ID":"HMDB0000897","m/z":"166.07231","MT/RT":"8.086751969"},{"Metabolite":"8-Hydroxyoctanoic acid","PubChem CID":"69820","HMDB ID":"","m/z":"159.102666","MT/RT":"8.288736033"},{"Metabolite":"Acetoacetamide","PubChem CID":"80077","HMDB ID":"","m/z":"102.054948","MT/RT":"11.50296638"},{"Metabolite":"Acetoacetic acid","PubChem CID":"96","HMDB ID":"HMDB0000060","m/z":"101.0243605","MT/RT":"11.11790209"},{"Metabolite":"Adenosine","PubChem CID":"60961","HMDB ID":"HMDB0000050","m/z":"268.1039767","MT/RT":"9.7360829"},{"Metabolite":"Adipic acid","PubChem CID":"196","HMDB ID":"HMDB0000448","m/z":"145.05054","MT/RT":"14.969602"},{"Metabolite":"ADMA","PubChem CID":"123831","HMDB ID":"HMDB0001539","m/z":"203.1501788","MT/RT":"7.523584444"},{"Metabolite":"ADP","PubChem CID":"6022","HMDB ID":"HMDB0001341","m/z":"426.0221","MT/RT":"11.09446469"},{"Metabolite":"ADP-ribose","PubChem CID":"445794","HMDB ID":"HMDB0001178","m/z":"558.064155","MT/RT":"8.6573053"},{"Metabolite":"Adrenaline","PubChem CID":"5816","HMDB ID":"HMDB0000068","m/z":"184.096744","MT/RT":"9.1757342"},{"Metabolite":"Ala","PubChem CID":"602","HMDB ID":"HMDB0000161,HMDB0001310","m/z":"90.05489625","MT/RT":"8.878543813"},{"Metabolite":"Albizziine","PubChem CID":"92891","HMDB ID":"","m/z":"148.07162","MT/RT":"10.8612226"},{"Metabolite":"Allantoic acid","PubChem CID":"203","HMDB ID":"HMDB0001209","m/z":"175.04724","MT/RT":"8.884275083"},{"Metabolite":"Allantoin","PubChem CID":"204","HMDB ID":"HMDB0000462","m/z":"159.0512275","MT/RT":"23.18339881"},{"Metabolite":"AMP","PubChem CID":"6083","HMDB ID":"HMDB0000045","m/z":"346.0556275","MT/RT":"9.44966175"},{"Metabolite":"Anserine_divalent","PubChem CID":"112072","HMDB ID":"","m/z":"121.068315","MT/RT":"6.716554869"},{"Metabolite":"Anthranilic acid","PubChem CID":"227","HMDB ID":"HMDB0001123","m/z":"138.05487","MT/RT":"10.52084567"},{"Metabolite":"Arg","PubChem CID":"6322","HMDB ID":"HMDB0000517,HMDB0003416","m/z":"175.1188394","MT/RT":"6.978338269"},{"Metabolite":"Argininosuccinic acid","PubChem CID":"16950","HMDB ID":"HMDB0000052","m/z":"291.1297163","MT/RT":"9.278297125"},{"Metabolite":"Ascorbate 2-phosphate","PubChem CID":"131711663","HMDB ID":"","m/z":"254.991168","MT/RT":"13.6896867"},{"Metabolite":"Ascorbate 2-sulfate","PubChem CID":"54676864","HMDB ID":"","m/z":"254.98164","MT/RT":"14.54069194"},{"Metabolite":"Asn","PubChem CID":"236","HMDB ID":"HMDB0000168,HMDB0033780","m/z":"133.06074","MT/RT":"10.35418663"},{"Metabolite":"Asp","PubChem CID":"424","HMDB ID":"HMDB0000191,HMDB0006483","m/z":"134.0447425","MT/RT":"11.45592513"},{"Metabolite":"ATP","PubChem CID":"5957","HMDB ID":"HMDB0000538","m/z":"505.988635","MT/RT":"12.02011616"},{"Metabolite":"Azelaic acid","PubChem CID":"2266","HMDB ID":"HMDB0000784","m/z":"187.0975629","MT/RT":"12.35197568"},{"Metabolite":"Azetidine 2-carboxylic acid","PubChem CID":"16486","HMDB ID":"","m/z":"102.05501","MT/RT":"8.743775"},{"Metabolite":"Betaine","PubChem CID":"247","HMDB ID":"HMDB0000043","m/z":"118.0862009","MT/RT":"11.16396256"},{"Metabolite":"Betonicine","PubChem CID":"164642","HMDB ID":"","m/z":"160.096766","MT/RT":"13.1025611"},{"Metabolite":"Biopterin","PubChem CID":"2380","HMDB ID":"HMDB0000468,HMDB0000633","m/z":"238.0934273","MT/RT":"11.80351427"},{"Metabolite":"Butyric acid　Isobutyric acid","PubChem CID":"264　6590","HMDB ID":"HMDB0000039　HMDB0001873","m/z":"87.04513889","MT/RT":"10.04071839"},{"Metabolite":"Butyrylcarnitine","PubChem CID":"439829","HMDB ID":"HMDB0002013","m/z":"232.15413","MT/RT":"9.439838438"},{"Metabolite":"cAMP","PubChem CID":"6076","HMDB ID":"HMDB0000058","m/z":"328.0450617","MT/RT":"7.693849917"},{"Metabolite":"Carboxymethyllysine","PubChem CID":"123800","HMDB ID":"","m/z":"205.1182481","MT/RT":"9.065448563"},{"Metabolite":"Carnitine","PubChem CID":"85","HMDB ID":"HMDB0000062","m/z":"162.1123625","MT/RT":"8.371893844"},{"Metabolite":"Carnosine","PubChem CID":"439224","HMDB ID":"HMDB0000033","m/z":"227.1137","MT/RT":"6.638301275"},{"Metabolite":"Cholic acid","PubChem CID":"221493","HMDB ID":"HMDB0000619","m/z":"407.2803013","MT/RT":"7.03079705"},{"Metabolite":"Choline","PubChem CID":"305","HMDB ID":"HMDB0000097","m/z":"104.106895","MT/RT":"6.730590638"},{"Metabolite":"cis-Aconitic acid","PubChem CID":"643757","HMDB ID":"HMDB0000072","m/z":"173.0090144","MT/RT":"29.06396025"},{"Metabolite":"Citric acid","PubChem CID":"311","HMDB ID":"HMDB0000094","m/z":"191.01972","MT/RT":"27.310001"},{"Metabolite":"Citrulline","PubChem CID":"9750","HMDB ID":"HMDB0000904","m/z":"176.1028175","MT/RT":"10.95041344"},{"Metabolite":"CMP","PubChem CID":"6131","HMDB ID":"HMDB0000095","m/z":"322.04456","MT/RT":"9.800796"},{"Metabolite":"CMP-N-acetylneuraminate","PubChem CID":"448209","HMDB ID":"HMDB0001176","m/z":"613.14001","MT/RT":"8.488634933"},{"Metabolite":"Creatine","PubChem CID":"586","HMDB ID":"HMDB0000064","m/z":"132.0767238","MT/RT":"8.713254594"},{"Metabolite":"Creatinine","PubChem CID":"588","HMDB ID":"HMDB0000562","m/z":"114.0661813","MT/RT":"7.164568013"},{"Metabolite":"Cys","PubChem CID":"594","HMDB ID":"HMDB0000574,HMDB0003417","m/z":"122.0269594","MT/RT":"11.204738"},{"Metabolite":"Cystathionine","PubChem CID":"834","HMDB ID":"HMDB0000099","m/z":"223.0746513","MT/RT":"9.766741281"},{"Metabolite":"Cysteine glutathione disulfide","PubChem CID":"10455148","HMDB ID":"HMDB0000656","m/z":"427.09485","MT/RT":"11.5548725"},{"Metabolite":"Cystine","PubChem CID":"595","HMDB ID":"HMDB0000192","m/z":"241.0309344","MT/RT":"10.87850981"},{"Metabolite":"Cytidine","PubChem CID":"6175","HMDB ID":"HMDB0000089","m/z":"244.0927025","MT/RT":"9.544667"},{"Metabolite":"Decarboxylated S-Adenosylmethionine","PubChem CID":"439415","HMDB ID":"HMDB0000988","m/z":"355.1545164","MT/RT":"5.563036582"},{"Metabolite":"dGDP","PubChem CID":"439220","HMDB ID":"HMDB0000960","m/z":"426.021775","MT/RT":"10.72267069"},{"Metabolite":"Diethanolamine","PubChem CID":"8113","HMDB ID":"HMDB0004437","m/z":"106.0862738","MT/RT":"7.510627425"},{"Metabolite":"Dihydroorotic acid","PubChem CID":"439216","HMDB ID":"HMDB0000528","m/z":"157.025155","MT/RT":"9.575654"},{"Metabolite":"Dihydroxyacetone phosphate","PubChem CID":"668","HMDB ID":"HMDB0001473","m/z":"168.99073","MT/RT":"12.89070462"},{"Metabolite":"Dodecanedioic acid","PubChem CID":"12736","HMDB ID":"HMDB0000623","m/z":"229.14433","MT/RT":"10.90775433"},{"Metabolite":"Ectoine","PubChem CID":"126041","HMDB ID":"","m/z":"143.0815413","MT/RT":"9.2928915"},{"Metabolite":"Ergothioneine","PubChem CID":"3037043","HMDB ID":"HMDB0003045","m/z":"230.0957871","MT/RT":"17.82694914"},{"Metabolite":"Ethanolamine","PubChem CID":"700","HMDB ID":"HMDB0000149","m/z":"62.06007738","MT/RT":"6.240012794"},{"Metabolite":"Ethanolamine phosphate","PubChem CID":"1015","HMDB ID":"HMDB0000224","m/z":"140.0118","MT/RT":"8.187037844"},{"Metabolite":"Ethionine","PubChem CID":"25674","HMDB ID":"","m/z":"164.07382","MT/RT":"10.9555435"},{"Metabolite":"Ethyl glucuronide","PubChem CID":"18392195","HMDB ID":"HMDB0010325","m/z":"221.0665613","MT/RT":"7.93164465"},{"Metabolite":"FAD_divalent","PubChem CID":"643975","HMDB ID":"","m/z":"391.5715013","MT/RT":"8.034734094"},{"Metabolite":"Ferulic acid","PubChem CID":"445858","HMDB ID":"HMDB0000954","m/z":"193.05056","MT/RT":"8.551871727"},{"Metabolite":"Formiminoglutamic acid","PubChem CID":"439233","HMDB ID":"HMDB0000854","m/z":"173.05664","MT/RT":"8.328956889"},{"Metabolite":"Formylanthranilic acid","PubChem CID":"101399","HMDB ID":"HMDB0004089","m/z":"164.0353444","MT/RT":"9.529685778"},{"Metabolite":"Fructose 6-phosphate","PubChem CID":"603","HMDB ID":"HMDB0000124","m/z":"259.0221333","MT/RT":"10.1595401"},{"Metabolite":"Fumaric acid","PubChem CID":"444972","HMDB ID":"HMDB0000134","m/z":"115.00357","MT/RT":"26.09251383"},{"Metabolite":"Galacturonic acid","PubChem CID":"439215","HMDB ID":"HMDB0002545","m/z":"193.03527","MT/RT":"8.432551625"},{"Metabolite":"GDP","PubChem CID":"8977","HMDB ID":"HMDB0001201","m/z":"442.01716","MT/RT":"10.86590715"},{"Metabolite":"Gibberellic acid","PubChem CID":"439551","HMDB ID":"HMDB0003559","m/z":"347.14758","MT/RT":"23.746529"},{"Metabolite":"Gln","PubChem CID":"738","HMDB ID":"HMDB0000641,HMDB0003423","m/z":"147.0763644","MT/RT":"10.62770447"},{"Metabolite":"Glu","PubChem CID":"611","HMDB ID":"HMDB0000148,HMDB0003339","m/z":"148.0604069","MT/RT":"10.83472494"},{"Metabolite":"Glucaric acid","PubChem CID":"33037","HMDB ID":"HMDB0000663","m/z":"209.0301925","MT/RT":"14.72148578"},{"Metabolite":"Gluconic acid","PubChem CID":"10690","HMDB ID":"HMDB0000625","m/z":"195.05097","MT/RT":"8.366522688"},{"Metabolite":"Gluconolactone","PubChem CID":"7027","HMDB ID":"HMDB0000150","m/z":"179.0549875","MT/RT":"24.14154063"},{"Metabolite":"Glucosamine　Galactosamine","PubChem CID":"439213　24154","HMDB ID":"HMDB0001514","m/z":"180.08658","MT/RT":"9.163216688"},{"Metabolite":"Glucosaminic acid","PubChem CID":"73563","HMDB ID":"","m/z":"196.0813933","MT/RT":"11.87402722"},{"Metabolite":"Glucose 1-phosphate","PubChem CID":"65533","HMDB ID":"HMDB0001586","m/z":"259.0224273","MT/RT":"10.33128973"},{"Metabolite":"Glucose 6-phosphate","PubChem CID":"5958","HMDB ID":"HMDB0001401","m/z":"259.0223988","MT/RT":"10.03524344"},{"Metabolite":"Glucuronic acid","PubChem CID":"94715","HMDB ID":"HMDB0000127","m/z":"193.03531","MT/RT":"8.263275719"},{"Metabolite":"Glutathione (GSH)","PubChem CID":"124886","HMDB ID":"HMDB0000125","m/z":"308.0910773","MT/RT":"13.224146"},{"Metabolite":"Glutathione (GSSG)_divalent","PubChem CID":"65359","HMDB ID":"","m/z":"307.0833331","MT/RT":"12.10971463"},{"Metabolite":"Gly","PubChem CID":"750","HMDB ID":"HMDB0000123","m/z":"76.03924813","MT/RT":"8.162901875"},{"Metabolite":"Gly-Asp","PubChem CID":"97363","HMDB ID":"","m/z":"191.0661706","MT/RT":"9.750000281"},{"Metabolite":"Gly-Gly","PubChem CID":"11163","HMDB ID":"HMDB0011733","m/z":"133.0607725","MT/RT":"8.234186188"},{"Metabolite":"Glyceric acid","PubChem CID":"439194","HMDB ID":"HMDB0000139,HMDB0006372","m/z":"105.0192688","MT/RT":"10.59590088"},{"Metabolite":"Glycerol","PubChem CID":"753","HMDB ID":"HMDB0000131","m/z":"93.05450725","MT/RT":"23.1616275"},{"Metabolite":"Glycerol 3-phosphate","PubChem CID":"439162","HMDB ID":"HMDB0000126","m/z":"171.00636","MT/RT":"12.36721844"},{"Metabolite":"Glycerophosphocholine","PubChem CID":"439285","HMDB ID":"HMDB0000086","m/z":"258.1100294","MT/RT":"22.71257125"},{"Metabolite":"Glycocholic acid","PubChem CID":"10140","HMDB ID":"HMDB0000138","m/z":"464.30203","MT/RT":"6.911691067"},{"Metabolite":"Glycolic acid","PubChem CID":"757","HMDB ID":"HMDB0000115","m/z":"75.00868438","MT/RT":"12.89821678"},{"Metabolite":"Glyoxylic acid","PubChem CID":"760","HMDB ID":"HMDB0000119","m/z":"72.99298885","MT/RT":"11.97374585"},{"Metabolite":"GMP","PubChem CID":"6804","HMDB ID":"HMDB0001397","m/z":"362.0507","MT/RT":"9.341491385"},{"Metabolite":"GTP","PubChem CID":"6830","HMDB ID":"HMDB0001273","m/z":"521.98334","MT/RT":"11.71068709"},{"Metabolite":"Guanidinosuccinic acid","PubChem CID":"439918","HMDB ID":"HMDB0003157","m/z":"176.0665338","MT/RT":"9.980186906"},{"Metabolite":"Guanidoacetic acid","PubChem CID":"763","HMDB ID":"HMDB0000128","m/z":"118.0610725","MT/RT":"8.089999063"},{"Metabolite":"Guanine","PubChem CID":"764","HMDB ID":"HMDB0000132","m/z":"152.0566767","MT/RT":"8.145240333"},{"Metabolite":"Hexamine","PubChem CID":"4101","HMDB ID":"","m/z":"141.1134367","MT/RT":"7.2162814"},{"Metabolite":"Hippuric acid","PubChem CID":"464","HMDB ID":"HMDB0000714","m/z":"178.0509119","MT/RT":"8.596769063"},{"Metabolite":"His","PubChem CID":"773","HMDB ID":"HMDB0000177","m/z":"156.0766744","MT/RT":"7.160788725"},{"Metabolite":"His-Glu","PubChem CID":"7010583","HMDB ID":"","m/z":"285.1192457","MT/RT":"7.433757071"},{"Metabolite":"Histamine","PubChem CID":"774","HMDB ID":"HMDB0000870","m/z":"112.086921","MT/RT":"4.722471531"},{"Metabolite":"Homoarginine","PubChem CID":"9085","HMDB ID":"HMDB0000670","m/z":"189.13455","MT/RT":"7.05822805"},{"Metabolite":"Homocarnosine","PubChem CID":"10243361","HMDB ID":"HMDB0000745","m/z":"241.12927","MT/RT":"6.714939106"},{"Metabolite":"Homocitrulline","PubChem CID":"65072","HMDB ID":"HMDB0000679","m/z":"190.11858","MT/RT":"11.0725915"},{"Metabolite":"Homocystine","PubChem CID":"439579","HMDB ID":"HMDB0000575,HMDB0000676","m/z":"269.0625056","MT/RT":"9.471056222"},{"Metabolite":"Homoserine","PubChem CID":"12647","HMDB ID":"HMDB0000719","m/z":"120.06551","MT/RT":"9.949390875"},{"Metabolite":"Homoserinelactone","PubChem CID":"73509","HMDB ID":"","m/z":"102.054917","MT/RT":"6.982378975"},{"Metabolite":"Homovanillic acid　3,4-Dihydroxyhydrocinnamic acid　Hydroxyphenyllactic acid","PubChem CID":"1738　348154　9378","HMDB ID":"HMDB0000118　HMDB0000423　HMDB0000755","m/z":"181.0506481","MT/RT":"8.4365755"},{"Metabolite":"Hydroxyindole","PubChem CID":"75421","HMDB ID":"","m/z":"134.0599744","MT/RT":"23.23274413"},{"Metabolite":"Hydroxyproline","PubChem CID":"5810","HMDB ID":"HMDB0000725","m/z":"132.065525","MT/RT":"11.96640625"},{"Metabolite":"Hypotaurine","PubChem CID":"107812","HMDB ID":"HMDB0000965","m/z":"110.0270356","MT/RT":"18.64026431"},{"Metabolite":"Hypoxanthine","PubChem CID":"790","HMDB ID":"HMDB0000157","m/z":"137.04572","MT/RT":"11.007572"},{"Metabolite":"Ile","PubChem CID":"791","HMDB ID":"HMDB0000172","m/z":"132.1018575","MT/RT":"10.08395334"},{"Metabolite":"Imidazole-4-acetic acid","PubChem CID":"96215","HMDB ID":"HMDB0002024","m/z":"127.0502119","MT/RT":"7.884261581"},{"Metabolite":"Imidazolelactic acid","PubChem CID":"793","HMDB ID":"","m/z":"157.0606775","MT/RT":"8.692178219"},{"Metabolite":"IMP","PubChem CID":"8582","HMDB ID":"HMDB0000175","m/z":"347.0395","MT/RT":"9.771506286"},{"Metabolite":"Indole-3-acetic acid","PubChem CID":"802","HMDB ID":"HMDB0000197","m/z":"174.0560247","MT/RT":"8.732891933"},{"Metabolite":"Indole-3-carboxylic acid","PubChem CID":"69867","HMDB ID":"HMDB0003320","m/z":"160.0403733","MT/RT":"8.971613722"},{"Metabolite":"Indole-3-propionic acid","PubChem CID":"3744","HMDB ID":"HMDB0002302","m/z":"188.0716063","MT/RT":"8.454041188"},{"Metabolite":"Inosine","PubChem CID":"6021","HMDB ID":"HMDB0000195","m/z":"269.08812","MT/RT":"20.20943"},{"Metabolite":"Isatin","PubChem CID":"7054","HMDB ID":"","m/z":"148.03928","MT/RT":"23.293318"},{"Metabolite":"Isethionic acid","PubChem CID":"7866","HMDB ID":"HMDB0003903","m/z":"124.9913631","MT/RT":"11.86692503"},{"Metabolite":"Isobutyrylcarnitine","PubChem CID":"168379","HMDB ID":"HMDB0000736","m/z":"232.153925","MT/RT":"9.360417281"},{"Metabolite":"Isocitric acid","PubChem CID":"1198","HMDB ID":"HMDB0000193","m/z":"191.01968","MT/RT":"29.80517563"},{"Metabolite":"Isoglutamic acid","PubChem CID":"73064","HMDB ID":"","m/z":"148.060475","MT/RT":"9.014910688"},{"Metabolite":"Isovaleric acid　Valeric acid　DL-2-Methylbutyric acid","PubChem CID":"10430　7991　8314","HMDB ID":"HMDB0000718　HMDB0000892　HMDB0002176","m/z":"101.06081","MT/RT":"9.422466"},{"Metabolite":"Isovalerylalanine","PubChem CID":"129285","HMDB ID":"HMDB0000747","m/z":"172.0978688","MT/RT":"8.158862875"},{"Metabolite":"Isovalerylcarnitine","PubChem CID":"6426851","HMDB ID":"HMDB0000688","m/z":"246.1700013","MT/RT":"9.658663375"},{"Metabolite":"Kynurenic acid","PubChem CID":"3845","HMDB ID":"HMDB0000715","m/z":"188.0352418","MT/RT":"8.732010818"},{"Metabolite":"Kynurenine","PubChem CID":"846","HMDB ID":"HMDB0000684","m/z":"209.0919463","MT/RT":"9.747843313"},{"Metabolite":"Lactic acid","PubChem CID":"612","HMDB ID":"HMDB0000190,HMDB0001311","m/z":"89.02437688","MT/RT":"11.04033463"},{"Metabolite":"Lauric acid","PubChem CID":"3893","HMDB ID":"HMDB0000638","m/z":"199.1702688","MT/RT":"7.818747025"},{"Metabolite":"Lauroylcarnitine","PubChem CID":"168381","HMDB ID":"HMDB0002250","m/z":"344.2795256","MT/RT":"11.01205828"},{"Metabolite":"Leu","PubChem CID":"857","HMDB ID":"HMDB0000687","m/z":"132.1018238","MT/RT":"10.19259284"},{"Metabolite":"Lipoamide","PubChem CID":"863","HMDB ID":"HMDB0000962","m/z":"206.0658653","MT/RT":"23.4329222"},{"Metabolite":"Lys","PubChem CID":"866","HMDB ID":"HMDB0000182,HMDB0003405","m/z":"147.1127331","MT/RT":"6.745698506"},{"Metabolite":"Malic acid","PubChem CID":"525","HMDB ID":"HMDB0000156,HMDB0000744","m/z":"133.0141906","MT/RT":"21.95410906"},{"Metabolite":"Malonylcarnitine","PubChem CID":"22833583","HMDB ID":"HMDB0002095","m/z":"248.1128879","MT/RT":"10.07875193"},{"Metabolite":"Mannosamine","PubChem CID":"440049","HMDB ID":"","m/z":"180.08658","MT/RT":"8.9927145"},{"Metabolite":"Met","PubChem CID":"876","HMDB ID":"HMDB0000696","m/z":"150.0582269","MT/RT":"10.60282438"},{"Metabolite":"Metanephrine","PubChem CID":"21100","HMDB ID":"HMDB0004063","m/z":"198.1124427","MT/RT":"9.297783636"},{"Metabolite":"Methionine sulfoxide","PubChem CID":"158980","HMDB ID":"HMDB0002005","m/z":"166.0531969","MT/RT":"11.69871847"},{"Metabolite":"Methyl sulfate","PubChem CID":"6412","HMDB ID":"","m/z":"110.97578","MT/RT":"16.007223"},{"Metabolite":"Methylguanidine","PubChem CID":"10111","HMDB ID":"HMDB0001522","m/z":"74.07125","MT/RT":"6.083035983"},{"Metabolite":"Mevalonic acid","PubChem CID":"134965","HMDB ID":"HMDB0000227","m/z":"147.066245","MT/RT":"8.740303375"},{"Metabolite":"Mucic acid","PubChem CID":"3037582","HMDB ID":"HMDB0000639","m/z":"209.030152","MT/RT":"14.0034376"},{"Metabolite":"Muscimol","PubChem CID":"4266","HMDB ID":"","m/z":"115.0502238","MT/RT":"7.410741125"},{"Metabolite":"myo-Inositol 1-phosphate　myo-Inositol 3-phosphate","PubChem CID":"107737　440194","HMDB ID":"HMDB0000213　HMDB0006814","m/z":"259.0222967","MT/RT":"10.47402213"},{"Metabolite":"Myristoleic acid","PubChem CID":"5281119","HMDB ID":"HMDB0002000","m/z":"225.185875","MT/RT":"7.647960325"},{"Metabolite":"N,N-Dimethylglycine","PubChem CID":"673","HMDB ID":"HMDB0000092","m/z":"104.0705398","MT/RT":"10.81743394"},{"Metabolite":"N-(1-Deoxy-1-fructosyl)valine","PubChem CID":"131752247","HMDB ID":"HMDB0037844","m/z":"280.13878","MT/RT":"14.08885594"},{"Metabolite":"N-Acetyl-β-alanine","PubChem CID":"76406","HMDB ID":"","m/z":"130.0508469","MT/RT":"9.177582219"},{"Metabolite":"N-Acetylalanine","PubChem CID":"88064","HMDB ID":"HMDB0000766","m/z":"130.0509769","MT/RT":"9.04286075"},{"Metabolite":"N-Acetylasparagine","PubChem CID":"99715","HMDB ID":"HMDB0006028","m/z":"173.0566825","MT/RT":"8.577104"},{"Metabolite":"N-Acetylaspartic acid","PubChem CID":"65065","HMDB ID":"HMDB0000812","m/z":"174.0406931","MT/RT":"14.75504288"},{"Metabolite":"N-Acetylglucosamine 1-phosphate","PubChem CID":"440272","HMDB ID":"HMDB0001367","m/z":"300.049045","MT/RT":"9.739040125"},{"Metabolite":"N-Acetylglucosamine　N-Acetylmannosamine　N-Acetylgalactosamine","PubChem CID":"439174　439281　35717","HMDB ID":"HMDB0000215　HMDB0001129　HMDB0000853","m/z":"222.0971063","MT/RT":"23.20231438"},{"Metabolite":"N-Acetylglucosylamine","PubChem CID":"439454","HMDB ID":"HMDB0001104","m/z":"221.113132","MT/RT":"9.8043015"},{"Metabolite":"N-Acetylglutamic acid","PubChem CID":"70914","HMDB ID":"HMDB0001138","m/z":"188.0563725","MT/RT":"13.45135669"},{"Metabolite":"N-Acetylglutamine","PubChem CID":"25561","HMDB ID":"HMDB0006029","m/z":"187.0724173","MT/RT":"8.272125233"},{"Metabolite":"N-Acetylglycine","PubChem CID":"10972","HMDB ID":"HMDB0000532","m/z":"116.0352943","MT/RT":"9.740509813"},{"Metabolite":"N-Acetylhistidine","PubChem CID":"75619","HMDB ID":"","m/z":"198.0872788","MT/RT":"9.684611563"},{"Metabolite":"N-Acetylleucine","PubChem CID":"70912","HMDB ID":"HMDB0011756","m/z":"172.0978693","MT/RT":"8.264077033"},{"Metabolite":"N-Acetyllysine","PubChem CID":"92907","HMDB ID":"HMDB0000446","m/z":"189.1233013","MT/RT":"9.646785469"},{"Metabolite":"N-Acetylmethionine","PubChem CID":"448580","HMDB ID":"HMDB0011745","m/z":"190.054275","MT/RT":"8.290807188"},{"Metabolite":"N-Acetylmuramic acid","PubChem CID":"5462244","HMDB ID":"","m/z":"292.1037218","MT/RT":"7.453827673"},{"Metabolite":"N-Acetylneuraminic acid","PubChem CID":"439197","HMDB ID":"HMDB0000230","m/z":"308.09864","MT/RT":"7.369217944"},{"Metabolite":"N-Acetylornithine","PubChem CID":"439232","HMDB ID":"HMDB0003357","m/z":"175.1076575","MT/RT":"9.430630875"},{"Metabolite":"N-Acetylphenylalanine","PubChem CID":"74839","HMDB ID":"HMDB0000512","m/z":"206.0821888","MT/RT":"8.149574781"},{"Metabolite":"N-Acetylputrescine","PubChem CID":"122356","HMDB ID":"HMDB0002064","m/z":"131.1178969","MT/RT":"8.310868719"},{"Metabolite":"N-Acetylserine","PubChem CID":"65249","HMDB ID":"HMDB0002931","m/z":"148.0604475","MT/RT":"24.43005113"},{"Metabolite":"N-Acetyltryptophan","PubChem CID":"439917","HMDB ID":"","m/z":"245.0931075","MT/RT":"7.8981992"},{"Metabolite":"N-Acetyltyrosine","PubChem CID":"68310","HMDB ID":"HMDB0000866","m/z":"222.07709","MT/RT":"7.929446694"},{"Metabolite":"N-Ethylmaleimide_+H2O","PubChem CID":"4362","HMDB ID":"","m/z":"144.065546","MT/RT":"24.01823773"},{"Metabolite":"N-Formylmethionine","PubChem CID":"439750","HMDB ID":"HMDB0001015","m/z":"176.038602","MT/RT":"8.628321433"},{"Metabolite":"N-Glycolylneuraminic acid","PubChem CID":"440001","HMDB ID":"HMDB0000833","m/z":"324.0935813","MT/RT":"7.353231269"},{"Metabolite":"N-Methylproline","PubChem CID":"557","HMDB ID":"","m/z":"130.0862631","MT/RT":"12.40612494"},{"Metabolite":"N1-Methyl-4-pyridone-5-carboxamide","PubChem CID":"440810","HMDB ID":"HMDB0004194","m/z":"153.0658306","MT/RT":"18.99279431"},{"Metabolite":"N1-Methylguanosine","PubChem CID":"96373","HMDB ID":"HMDB0001563","m/z":"298.1143881","MT/RT":"11.85500334"},{"Metabolite":"N2-Acetylaminoadipic acid","PubChem CID":"443992","HMDB ID":"","m/z":"202.07216","MT/RT":"12.424466"},{"Metabolite":"N6,N6,N6-Trimethyllysine","PubChem CID":"440120","HMDB ID":"HMDB0001325","m/z":"189.1596719","MT/RT":"7.047971644"},{"Metabolite":"N6-Acetyllysine","PubChem CID":"92832","HMDB ID":"HMDB0000206","m/z":"189.1233013","MT/RT":"11.34832513"},{"Metabolite":"N6-Methyl-2'-deoxyadenosine","PubChem CID":"168948","HMDB ID":"","m/z":"266.123577","MT/RT":"9.8403101"},{"Metabolite":"N6-Methyllysine","PubChem CID":"164795","HMDB ID":"HMDB0002038","m/z":"161.1282988","MT/RT":"6.964847856"},{"Metabolite":"N8-Acetylspermidine","PubChem CID":"123689","HMDB ID":"HMDB0002189","m/z":"188.1756825","MT/RT":"6.229227469"},{"Metabolite":"Nalidixic acid","PubChem CID":"4421","HMDB ID":"","m/z":"231.0773563","MT/RT":"8.060656"},{"Metabolite":"Nicotinamide","PubChem CID":"936","HMDB ID":"HMDB0001406","m/z":"123.0552","MT/RT":"7.262288256"},{"Metabolite":"Noradrenaline　6-Hydroxydopamine","PubChem CID":"439260　4624","HMDB ID":"HMDB0000216　HMDB0001537","m/z":"170.081096","MT/RT":"8.8520417"},{"Metabolite":"N’-Formylkynurenine","PubChem CID":"910","HMDB ID":"HMDB0001200","m/z":"237.0868588","MT/RT":"12.04048525"},{"Metabolite":"Nω-Methylarginine","PubChem CID":"132862","HMDB ID":"","m/z":"189.13445","MT/RT":"7.315725869"},{"Metabolite":"O-Acetylcarnitine","PubChem CID":"439756","HMDB ID":"HMDB0000201","m/z":"204.1229263","MT/RT":"8.88664975"},{"Metabolite":"o-Hydroxybenzoic acid","PubChem CID":"338","HMDB ID":"HMDB0001895","m/z":"137.0243693","MT/RT":"10.66581496"},{"Metabolite":"O-Sulfoserine","PubChem CID":"164701","HMDB ID":"","m/z":"183.9919457","MT/RT":"10.73117143"},{"Metabolite":"Octanoylcarnitine","PubChem CID":"11953814","HMDB ID":"HMDB0000791","m/z":"288.2169429","MT/RT":"10.28703486"},{"Metabolite":"Octopine","PubChem CID":"440237","HMDB ID":"","m/z":"247.14008","MT/RT":"10.591394"},{"Metabolite":"Ophthalmic acid","PubChem CID":"7018721","HMDB ID":"HMDB0005765","m/z":"290.1345","MT/RT":"13.20732456"},{"Metabolite":"Ornithine","PubChem CID":"389","HMDB ID":"HMDB0000214,HMDB0003374","m/z":"133.0970938","MT/RT":"6.688491556"},{"Metabolite":"Orotic acid","PubChem CID":"967","HMDB ID":"HMDB0000226","m/z":"155.0098756","MT/RT":"10.15872253"},{"Metabolite":"Orotidine","PubChem CID":"92751","HMDB ID":"HMDB0000788","m/z":"287.052115","MT/RT":"8.127243188"},{"Metabolite":"p-Hydroxymandelic acid　Homogentisic acid","PubChem CID":"328　780","HMDB ID":"HMDB0000822　HMDB0000130","m/z":"167.0349","MT/RT":"8.76323575"},{"Metabolite":"p-Hydroxyphenylpyruvic acid","PubChem CID":"979","HMDB ID":"HMDB0000707","m/z":"179.034928","MT/RT":"8.904305933"},{"Metabolite":"Pantothenic acid","PubChem CID":"6613","HMDB ID":"HMDB0000210","m/z":"218.1033413","MT/RT":"7.837696513"},{"Metabolite":"Pargyline","PubChem CID":"4688","HMDB ID":"","m/z":"160.1127291","MT/RT":"8.273089727"},{"Metabolite":"Perillic acid","PubChem CID":"1256","HMDB ID":"HMDB0004586","m/z":"165.0919813","MT/RT":"8.314040969"},{"Metabolite":"Phe","PubChem CID":"994","HMDB ID":"HMDB0000159","m/z":"166.0861413","MT/RT":"10.98284788"},{"Metabolite":"Phenaceturic acid　N-(o-Toluoyl)glycine","PubChem CID":"68144　91637","HMDB ID":"HMDB0000821　HMDB0011723","m/z":"192.06658","MT/RT":"8.385117625"},{"Metabolite":"Phenol","PubChem CID":"996","HMDB ID":"HMDB0000228","m/z":"93.03451125","MT/RT":"5.778551938"},{"Metabolite":"Phosphocreatine","PubChem CID":"9548602","HMDB ID":"HMDB0001511","m/z":"210.02844","MT/RT":"12.48909088"},{"Metabolite":"Phosphorylcholine","PubChem CID":"1014","HMDB ID":"HMDB0001565","m/z":"184.0733388","MT/RT":"21.43344231"},{"Metabolite":"Phthalic acid","PubChem CID":"1017","HMDB ID":"HMDB0002107","m/z":"165.01907","MT/RT":"16.085588"},{"Metabolite":"Picolinic acid","PubChem CID":"1018","HMDB ID":"HMDB0002243","m/z":"124.039321","MT/RT":"19.27760083"},{"Metabolite":"Pipecolic acid","PubChem CID":"439227","HMDB ID":"HMDB0000070,HMDB0000716,HMDB0005960","m/z":"130.0862525","MT/RT":"10.146101"},{"Metabolite":"Piperidine","PubChem CID":"8082","HMDB ID":"","m/z":"86.09637714","MT/RT":"6.8435814"},{"Metabolite":"Pro","PubChem CID":"614","HMDB ID":"HMDB0000162,HMDB0003411","m/z":"116.0705914","MT/RT":"10.69093931"},{"Metabolite":"Propionic acid","PubChem CID":"1032","HMDB ID":"HMDB0000237","m/z":"73.02939125","MT/RT":"11.1092385"},{"Metabolite":"Prostaglandin E2","PubChem CID":"5280360","HMDB ID":"HMDB0001220","m/z":"351.21765","MT/RT":"7.238762614"},{"Metabolite":"Putrescine","PubChem CID":"1045","HMDB ID":"HMDB0001414","m/z":"89.10726125","MT/RT":"4.559643544"},{"Metabolite":"Pyridoxal","PubChem CID":"1050","HMDB ID":"HMDB0001545","m/z":"168.0654425","MT/RT":"8.636551688"},{"Metabolite":"Pyridoxamine","PubChem CID":"1052","HMDB ID":"HMDB0001431","m/z":"169.0970914","MT/RT":"5.859574843"},{"Metabolite":"Pyridoxine","PubChem CID":"1054","HMDB ID":"HMDB0000239","m/z":"170.0810122","MT/RT":"8.49282"},{"Metabolite":"Pyruvic acid","PubChem CID":"1060","HMDB ID":"HMDB0000243","m/z":"87.008715","MT/RT":"13.17088025"},{"Metabolite":"Quinolinic acid","PubChem CID":"1066","HMDB ID":"HMDB0000232","m/z":"166.0144536","MT/RT":"15.81057759"},{"Metabolite":"Retinoic acid","PubChem CID":"444795","HMDB ID":"HMDB0001852","m/z":"299.2016286","MT/RT":"7.353370871"},{"Metabolite":"Riboflavin","PubChem CID":"493570","HMDB ID":"HMDB0000244","m/z":"377.1453513","MT/RT":"23.04157225"},{"Metabolite":"Ribose 5-phosphate","PubChem CID":"439167","HMDB ID":"HMDB0001548","m/z":"229.0117608","MT/RT":"10.78915542"},{"Metabolite":"Ribulose 5-phosphate","PubChem CID":"439184","HMDB ID":"HMDB0000618","m/z":"229.0116938","MT/RT":"11.20576906"},{"Metabolite":"S-Adenosylhomocysteine","PubChem CID":"439155","HMDB ID":"HMDB0000939","m/z":"385.1287707","MT/RT":"8.596364067"},{"Metabolite":"S-Adenosylmethionine","PubChem CID":"34755","HMDB ID":"HMDB0001185","m/z":"399.1444563","MT/RT":"6.976724475"},{"Metabolite":"S-Carboxymethylcysteine","PubChem CID":"193653","HMDB ID":"","m/z":"180.0324406","MT/RT":"13.01633453"},{"Metabolite":"S-Lactoylglutathione","PubChem CID":"440018","HMDB ID":"HMDB0001066","m/z":"380.1121","MT/RT":"13.806778"},{"Metabolite":"S-Methylcysteine","PubChem CID":"24417","HMDB ID":"HMDB0002108","m/z":"136.0426575","MT/RT":"11.47917488"},{"Metabolite":"S-Methylglutathione","PubChem CID":"115260","HMDB ID":"","m/z":"322.10658","MT/RT":"13.35719556"},{"Metabolite":"S-Methylmethionine","PubChem CID":"145692","HMDB ID":"","m/z":"164.073775","MT/RT":"7.164565119"},{"Metabolite":"S-Sulfocysteine","PubChem CID":"115015","HMDB ID":"HMDB0000731","m/z":"199.9692294","MT/RT":"11.38558459"},{"Metabolite":"Saccharopine","PubChem CID":"160556","HMDB ID":"HMDB0000279","m/z":"277.13933","MT/RT":"10.60741007"},{"Metabolite":"Sarcosine","PubChem CID":"1088","HMDB ID":"HMDB0000271","m/z":"90.05490938","MT/RT":"9.329088813"},{"Metabolite":"SDMA","PubChem CID":"169148","HMDB ID":"HMDB0003334","m/z":"203.1502006","MT/RT":"7.653704656"},{"Metabolite":"Sebacic acid","PubChem CID":"5192","HMDB ID":"HMDB0000792","m/z":"201.11308","MT/RT":"11.627408"},{"Metabolite":"Sedoheptulose 7-phosphate","PubChem CID":"165007","HMDB ID":"HMDB0001068","m/z":"289.0329931","MT/RT":"9.8042765"},{"Metabolite":"Ser","PubChem CID":"617","HMDB ID":"HMDB0000187,HMDB0003406","m/z":"106.0498738","MT/RT":"9.845098313"},{"Metabolite":"Serotonin","PubChem CID":"5202","HMDB ID":"HMDB0000259","m/z":"177.1021581","MT/RT":"8.630061063"},{"Metabolite":"Spermidine","PubChem CID":"1102","HMDB ID":"HMDB0001257","m/z":"146.165175","MT/RT":"4.525093306"},{"Metabolite":"Spermine","PubChem CID":"1103","HMDB ID":"HMDB0001256","m/z":"203.2229788","MT/RT":"4.502982069"},{"Metabolite":"Stachydrine","PubChem CID":"115244","HMDB ID":"HMDB0004827","m/z":"144.101865","MT/RT":"11.41698706"},{"Metabolite":"Suberic acid","PubChem CID":"10457","HMDB ID":"HMDB0000893","m/z":"173.0818009","MT/RT":"13.0363495"},{"Metabolite":"Succinic acid","PubChem CID":"1110","HMDB ID":"HMDB0000254","m/z":"117.01931","MT/RT":"21.5115256"},{"Metabolite":"Sulfotyrosine","PubChem CID":"514186","HMDB ID":"","m/z":"260.0234875","MT/RT":"8.544837969"},{"Metabolite":"Taurine","PubChem CID":"1123","HMDB ID":"HMDB0000251","m/z":"126.0218781","MT/RT":"23.17409419"},{"Metabolite":"Taurocholic acid","PubChem CID":"46783527","HMDB ID":"HMDB0000036","m/z":"514.2841125","MT/RT":"6.900060619"},{"Metabolite":"Taurocyamine","PubChem CID":"68340","HMDB ID":"HMDB0003584","m/z":"168.04372","MT/RT":"23.1689434"},{"Metabolite":"Thiamine","PubChem CID":"1130","HMDB ID":"HMDB0000235","m/z":"265.1116125","MT/RT":"6.467758969"},{"Metabolite":"Thiamine diphosphate","PubChem CID":"1132","HMDB ID":"HMDB0001372","m/z":"423.0301","MT/RT":"8.091648"},{"Metabolite":"Thiamine phosphate","PubChem CID":"1131","HMDB ID":"HMDB0002666","m/z":"345.0780375","MT/RT":"10.59471081"},{"Metabolite":"Thiaproline","PubChem CID":"9934","HMDB ID":"","m/z":"134.0269938","MT/RT":"14.01961509"},{"Metabolite":"Thr","PubChem CID":"6288","HMDB ID":"HMDB0000167","m/z":"120.06551","MT/RT":"10.39148613"},{"Metabolite":"threo-β-Methylaspartic acid","PubChem CID":"440064","HMDB ID":"","m/z":"148.0604033","MT/RT":"12.25796613"},{"Metabolite":"Threonic acid","PubChem CID":"5460407","HMDB ID":"HMDB0000943","m/z":"135.0299475","MT/RT":"9.416961031"},{"Metabolite":"Thymidine","PubChem CID":"5789","HMDB ID":"HMDB0000273","m/z":"243.0976013","MT/RT":"23.22034419"},{"Metabolite":"Thymine","PubChem CID":"1135","HMDB ID":"HMDB0000262","m/z":"127.0500725","MT/RT":"23.22136531"},{"Metabolite":"trans-Cinnamic acid","PubChem CID":"444539","HMDB ID":"HMDB0000930","m/z":"147.045085","MT/RT":"9.0640661"},{"Metabolite":"trans-Glutaconic acid","PubChem CID":"5280498","HMDB ID":"HMDB0000620","m/z":"131.0339273","MT/RT":"24.19424113"},{"Metabolite":"Triethanolamine","PubChem CID":"7618","HMDB ID":"","m/z":"150.1124869","MT/RT":"8.101870469"},{"Metabolite":"Trigonelline","PubChem CID":"5570","HMDB ID":"HMDB0000875","m/z":"138.054895","MT/RT":"10.32501113"},{"Metabolite":"Trimethylamine","PubChem CID":"1146","HMDB ID":"HMDB0000906","m/z":"60.08088777","MT/RT":"5.790250023"},{"Metabolite":"Trimethylamine N-oxide","PubChem CID":"1145","HMDB ID":"HMDB0000925","m/z":"76.07563963","MT/RT":"6.479621113"},{"Metabolite":"Trp","PubChem CID":"1148","HMDB ID":"HMDB0000929","m/z":"205.0969844","MT/RT":"10.90878394"},{"Metabolite":"Tyr","PubChem CID":"1153","HMDB ID":"HMDB0000158","m/z":"182.0810706","MT/RT":"11.26073084"},{"Metabolite":"Tyr-Glu","PubChem CID":"","HMDB ID":"","m/z":"311.1236638","MT/RT":"11.04545315"},{"Metabolite":"Tyrosine methyl ester","PubChem CID":"70652","HMDB ID":"","m/z":"196.0968713","MT/RT":"9.059496625"},{"Metabolite":"UDP","PubChem CID":"6031","HMDB ID":"HMDB0000295","m/z":"402.9953","MT/RT":"11.9160845"},{"Metabolite":"UDP-glucose　UDP-galactose","PubChem CID":"8629　23724458","HMDB ID":"HMDB0000286　HMDB0000302","m/z":"565.0475","MT/RT":"8.806845813"},{"Metabolite":"UDP-N-acetylglucosamine　UDP-N-acetylgalactosamine","PubChem CID":"445675　23724461","HMDB ID":"HMDB0000290　HMDB0000304","m/z":"606.0747457","MT/RT":"8.610495429"},{"Metabolite":"UMP","PubChem CID":"6030","HMDB ID":"HMDB0000288","m/z":"323.02868","MT/RT":"10.0014886"},{"Metabolite":"Uracil","PubChem CID":"1174","HMDB ID":"HMDB0000300","m/z":"113.0344975","MT/RT":"23.21811456"},{"Metabolite":"Urea","PubChem CID":"1176","HMDB ID":"HMDB0000294","m/z":"61.03965556","MT/RT":"22.11037069"},{"Metabolite":"Ureidoglycolic acid","PubChem CID":"439269","HMDB ID":"HMDB0001005","m/z":"133.02545","MT/RT":"9.908567"},{"Metabolite":"Uric acid","PubChem CID":"1175","HMDB ID":"HMDB0000289","m/z":"167.0210475","MT/RT":"9.079668875"},{"Metabolite":"Uridine","PubChem CID":"6029","HMDB ID":"HMDB0000296","m/z":"245.0766425","MT/RT":"23.25237488"},{"Metabolite":"Urocanic acid","PubChem CID":"736715","HMDB ID":"HMDB0000301","m/z":"139.0501775","MT/RT":"8.142913063"},{"Metabolite":"UTP","PubChem CID":"6133","HMDB ID":"HMDB0000285","m/z":"482.96085","MT/RT":"12.8671065"},{"Metabolite":"Val","PubChem CID":"1182","HMDB ID":"HMDB0000883","m/z":"118.08621","MT/RT":"9.882917781"},{"Metabolite":"XA0003","PubChem CID":"","HMDB ID":"","m/z":"124.9913255","MT/RT":"12.82195745"},{"Metabolite":"XA0004","PubChem CID":"","HMDB ID":"","m/z":"144.0301863","MT/RT":"9.497173594"},{"Metabolite":"XA0012","PubChem CID":"","HMDB ID":"","m/z":"166.0178825","MT/RT":"9.608073688"},{"Metabolite":"XA0013","PubChem CID":"","HMDB ID":"","m/z":"172.99133","MT/RT":"11.05272597"},{"Metabolite":"XA0017","PubChem CID":"","HMDB ID":"","m/z":"186.1134491","MT/RT":"8.070169955"},{"Metabolite":"XA0019","PubChem CID":"","HMDB ID":"","m/z":"191.0197","MT/RT":"8.466887688"},{"Metabolite":"XA0027","PubChem CID":"","HMDB ID":"","m/z":"227.2015544","MT/RT":"7.596447544"},{"Metabolite":"XA0035","PubChem CID":"","HMDB ID":"","m/z":"254.9817","MT/RT":"13.94027072"},{"Metabolite":"Xanthine","PubChem CID":"1188","HMDB ID":"HMDB0000292","m/z":"153.04082","MT/RT":"20.194321"},{"Metabolite":"Xanthosine","PubChem CID":"64959","HMDB ID":"HMDB0000299","m/z":"283.0684","MT/RT":"7.788366827"},{"Metabolite":"Xanthurenic acid","PubChem CID":"5699","HMDB ID":"HMDB0000881","m/z":"204.0300367","MT/RT":"12.82118342"},{"Metabolite":"XC0016","PubChem CID":"","HMDB ID":"","m/z":"129.0658","MT/RT":"8.631145688"},{"Metabolite":"XC0017","PubChem CID":"","HMDB ID":"","m/z":"130.0975067","MT/RT":"7.677389711"},{"Metabolite":"XC0029","PubChem CID":"","HMDB ID":"","m/z":"144.10191","MT/RT":"12.17549527"},{"Metabolite":"XC0040","PubChem CID":"","HMDB ID":"","m/z":"174.0872788","MT/RT":"12.10323481"},{"Metabolite":"XC0061　Propionylcarnitine","PubChem CID":"0　188824","HMDB ID":"　HMDB0000824","m/z":"218.138605","MT/RT":"9.181601094"},{"Metabolite":"XC0065","PubChem CID":"","HMDB ID":"","m/z":"221.0919975","MT/RT":"13.08342109"},{"Metabolite":"XC0071","PubChem CID":"","HMDB ID":"","m/z":"234.1811125","MT/RT":"6.114824488"},{"Metabolite":"XC0089　Nicotinamide riboside","PubChem CID":"0　439924","HMDB ID":"HMDB0000855","m/z":"255.0974569","MT/RT":"9.389053688"},{"Metabolite":"XC0120","PubChem CID":"","HMDB ID":"","m/z":"298.0525013","MT/RT":"9.332865781"},{"Metabolite":"XC0126","PubChem CID":"","HMDB ID":"","m/z":"310.1131575","MT/RT":"15.08819688"},{"Metabolite":"XC0132","PubChem CID":"","HMDB ID":"","m/z":"325.16045","MT/RT":"8.54040725"},{"Metabolite":"XC0145","PubChem CID":"15331","HMDB ID":"","m/z":"161.0925208","MT/RT":"9.125895667"},{"Metabolite":"XC0146","PubChem CID":"203443","HMDB ID":"","m/z":"163.107642","MT/RT":"8.543017"},{"Metabolite":"XC0150","PubChem CID":"11082","HMDB ID":"","m/z":"217.063725","MT/RT":"10.459611"},{"Metabolite":"Xylulose 5-phosphate","PubChem CID":"439190","HMDB ID":"HMDB0000868","m/z":"229.0115986","MT/RT":"10.80729804"},{"Metabolite":"β-Ala","PubChem CID":"239","HMDB ID":"HMDB0000056","m/z":"90.05492875","MT/RT":"7.207221525"},{"Metabolite":"β-Ala-Lys","PubChem CID":"440638","HMDB ID":"","m/z":"218.1497038","MT/RT":"6.6668985"},{"Metabolite":"β-Tyr","PubChem CID":"440311","HMDB ID":"HMDB0003831","m/z":"182.0811089","MT/RT":"9.417910889"},{"Metabolite":"γ-Butyrobetaine","PubChem CID":"134","HMDB ID":"HMDB0001161","m/z":"146.1175325","MT/RT":"7.950668738"},{"Metabolite":"γ-Glu-Ala","PubChem CID":"440103","HMDB ID":"HMDB0006248","m/z":"219.09752","MT/RT":"12.24547956"},{"Metabolite":"γ-Glu-Arg_divalent","PubChem CID":"20719180","HMDB ID":"","m/z":"152.5843931","MT/RT":"8.563628375"},{"Metabolite":"γ-Glu-Asn","PubChem CID":"131801686","HMDB ID":"HMDB0029144","m/z":"262.10327","MT/RT":"12.69064188"},{"Metabolite":"γ-Glu-Asp","PubChem CID":"161197","HMDB ID":"HMDB0030419","m/z":"263.0875314","MT/RT":"13.020948"},{"Metabolite":"γ-Glu-Citrulline","PubChem CID":"","HMDB ID":"","m/z":"305.1454906","MT/RT":"13.17270175"},{"Metabolite":"γ-Glu-Gln","PubChem CID":"150914","HMDB ID":"HMDB0011738","m/z":"276.119064","MT/RT":"12.96815577"},{"Metabolite":"γ-Glu-Glu","PubChem CID":"92865","HMDB ID":"HMDB0011737","m/z":"277.1030169","MT/RT":"13.07747175"},{"Metabolite":"γ-Glu-Gly","PubChem CID":"165527","HMDB ID":"HMDB0011667","m/z":"205.0817956","MT/RT":"11.96369519"},{"Metabolite":"γ-Glu-His","PubChem CID":"7017195","HMDB ID":"HMDB0029151","m/z":"285.1192975","MT/RT":"8.5614615"},{"Metabolite":"γ-Glu-Ile　γ-Glu-Leu","PubChem CID":"22885096　151023","HMDB ID":"HMDB0011170　HMDB0011171","m/z":"261.144435","MT/RT":"12.88811678"},{"Metabolite":"γ-Glu-Lys_divalent","PubChem CID":"65254","HMDB ID":"","m/z":"138.5813525","MT/RT":"8.431310688"},{"Metabolite":"γ-Glu-Met","PubChem CID":"7009567","HMDB ID":"HMDB0034367","m/z":"279.1008988","MT/RT":"12.92220028"},{"Metabolite":"γ-Glu-Ornitine","PubChem CID":"189156","HMDB ID":"HMDB0002248","m/z":"262.1394211","MT/RT":"8.339528778"},{"Metabolite":"γ-Glu-Phe","PubChem CID":"111299","HMDB ID":"HMDB0000594","m/z":"295.128695","MT/RT":"13.01091263"},{"Metabolite":"γ-Glu-Ser","PubChem CID":"22844748","HMDB ID":"HMDB0029158","m/z":"235.0924056","MT/RT":"12.54511919"},{"Metabolite":"γ-Glu-Taurine","PubChem CID":"68759","HMDB ID":"HMDB0004195","m/z":"253.0498756","MT/RT":"8.307880844"},{"Metabolite":"γ-Glu-Thr","PubChem CID":"53861142","HMDB ID":"HMDB0029159","m/z":"249.1080819","MT/RT":"12.67928619"},{"Metabolite":"γ-Glu-Trp","PubChem CID":"3038501","HMDB ID":"HMDB0029160","m/z":"334.1396044","MT/RT":"13.10831628"},{"Metabolite":"γ-Glu-Tyr","PubChem CID":"94340","HMDB ID":"HMDB0011741","m/z":"311.123785","MT/RT":"13.22030288"},{"Metabolite":"γ-Glu-Val","PubChem CID":"7015683","HMDB ID":"HMDB0011172","m/z":"247.128785","MT/RT":"12.66738775"},{"Metabolite":"γ-Glu-Val-Gly","PubChem CID":"","HMDB ID":"","m/z":"304.1504175","MT/RT":"13.38105163"}]
}

}