{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002153","ANALYSIS_ID":"AN003527","VERSION":"1","CREATED_ON":"April 19, 2022, 12:02 am"},

"PROJECT":{"PROJECT_TITLE":"Improvement of cognitive function by B. breve MCC1274 and elucidation of its mechanism of action","PROJECT_SUMMARY":"Although many studies have suggested that probiotics could modulate various brain functions via the gut-brain axis, little is known about the mechanism underlying this process. We previously reported the beneficial effects of a probiotic strain, Bifidobacterium breve MCC1274, on cognitive function in preclinical and clinical studies. Recently, we showed that administration of this strain reduced amyloid-beta production, inhibited microglial activation, and suppressed inflammatory responses in the brains of APP knock-in (AppNL-G-F) mice. To elucidate the mechanism of action of this probiotic strain in an Alzheimer's disease-like model, we orally fed 3-month-old mice with B. breve MCC1274 or saline for 4 months and comprehensively investigated metabolites in plasma using CE-FTMS and LC-TOFMS.","INSTITUTE":"Morinaga milk industry CO., LTD.","DEPARTMENT":"Next generation science institute","LABORATORY":"Frontier research section","LAST_NAME":"Ohno","FIRST_NAME":"Kazuya","ADDRESS":"1-83 5-Chome Higashihara, Zama-city, Kanagawa-Pref. Japan","EMAIL":"kazuya-oono443@morinagamilk.co.jp","PHONE":"81462523067"},

"STUDY":{"STUDY_TITLE":"Data from plasma metabolome analysis of APP-KI and Wild type mice treated with B. breve MCC1274","STUDY_SUMMARY":"Recently, we showed that administration of B. breve MCC1274 reduced amyloid-beta production, inhibited microglial activation, and suppressed inflammatory responses in the brains of APP knock-in (AppNL-G-F) mice. To elucidate the mechanism of action of this probiotic strain in an Alzheimer's disease-like model, we orally fed 3-month-old mice with B. breve MCC1274 or saline for 4 months and comprehensively investigated metabolites in plasma using CE-FTMS and LC-TOFMS.","INSTITUTE":"Morinaga milk industry CO., LTD.","DEPARTMENT":"Next generation science institute","LABORATORY":"Frontier research section","LAST_NAME":"Ohno","FIRST_NAME":"Kazuya","ADDRESS":"1-83 5-Chome Higashihara, Zama-city, Kanagawa-Pref. Japan","EMAIL":"kazuya-oono443@morinagamilk.co.jp","PHONE":"81462523067"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090","GENOTYPE_STRAIN":"AppNL-G-F or wild type mice","AGE_OR_AGE_RANGE":"7 months old","GENDER":"Male and female","ANIMAL_ANIMAL_SUPPLIER":"RIKEN Center for Brain Science","ANIMAL_LIGHT_CYCLE":"12 hours light and dark cycle"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"WC-1",
"Factors":{"Model":"Wild type","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"WC-2",
"Factors":{"Model":"Wild type","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"WC-3",
"Factors":{"Model":"Wild type","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"WC-4",
"Factors":{"Model":"Wild type","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"WT-1",
"Factors":{"Model":"Wild type","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"WT-2",
"Factors":{"Model":"Wild type","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"WT-3",
"Factors":{"Model":"Wild type","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"WT-4",
"Factors":{"Model":"Wild type","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"AC-1",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"AC-2",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"AC-3",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"AC-4",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"Saline"}
},
{
"Subject ID":"-",
"Sample ID":"AT-1",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"AT-2",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"AT-3",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"B. breve MCC1274"}
},
{
"Subject ID":"-",
"Sample ID":"AT-4",
"Factors":{"Model":"Alzheimer’s disease model","Intervention":"B. breve MCC1274"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Plasma samples were obtained from AD-like model and wild-type mice orally administered B. breve MCC1274 or saline for 4 months.","SAMPLE_TYPE":"Blood (plasma)","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"Three-month-old AppNL-G-F and wild type mice were randomly assigned to a vehicle group and a probiotic group. The vehicle group received saline, and the probiotic group received B. breve MCC1274 (1 × 10＾9 cfu/200 μl saline/mouse) orally 5 times a week for 4 months.","TREATMENT_COMPOUND":"Bifidobacterium breve MCC1274","TREATMENT_ROUTE":"oral administration","TREATMENT_DOSEVOLUME":"1 × 10＾9 cfu/200 μl saline","TREATMENT_VEHICLE":"saline"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"For CE-FTMS, 40 µL of plasma was added to 160 µL of methanol containing internal standards at 0°C, 120 µL of Milli-Q water was added and mixed thoroughly, and 240 µL of this mixture was added to a Millipore 5 kDa cutoff filter (ULTRAFREE MC PLHCC, HMT) at 9100 × g for 120 min at 4°C to remove macromolecules. The filtrate was evaporated to dryness under vacuum, dissolved in 40 µL Milli-Q water, and donated to HMT's ω Scan package using capillary electrophoresis Fourier transform mass spectrometry (CE-FTMS).For LC-TOFMS, 80 µL of plasma was added to 240 µL of 1% formic acid/acetonitrile containing internal standards at 0ºC. The mixture was centrifuged at 2,300 x g, 4ºC for 5 min, then centrifuged at 2,300 x g, 4ºC for 5 min, followed by centrifugation of a hybrid SPE phospholipid cartridge (30 mg/mL of hybrid SPE-phospholipid, 30 mg/mL of (SUPELCO) and filtered to remove phospholipids. The filtrate was then evaporated to dryness under nitrogen, dissolved in 80 μL of 50% isopropanol (v/v), and metabolomic analysis was performed using liquid chromatography time-of-flight mass spectrometry (LC-TOFMS)."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Agilent 1200","COLUMN_NAME":"ODS column","INTERNAL_STANDARD":"H3304-1002, Human Metabolome Technologies, Inc. (HMT), Tsuruoka, Yamagata, Japan"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 6210 TOF","INSTRUMENT_TYPE":"Triple TOF","MS_TYPE":"ESI","ION_MODE":"UNSPECIFIED","MS_COMMENTS":"The spectrometer was scanned from m/z 50 to 1,000 and peaks were extracted using MasterHands, automatic integration software (Keio University, Tsuruoka, Yamagata, Japan)"},

"MS_METABOLITE_DATA":{
"Units":"peak area",

"Data":[{"Metabolite":"1,2-Dipalmitoyl-glycero-3-phosphoethanolamine-1","WC-1":"N.D.","WC-2":"2.4E-05","WC-3":"2.2E-05","WC-4":"2.5E-05","WT-1":"2.1E-05","WT-2":"2.2E-05","WT-3":"N.D.","WT-4":"3.6E-05","AC-1":"N.D.","AC-2":"N.D.","AC-3":"1.4E-05","AC-4":"2.4E-05","AT-1":"2.5E-05","AT-2":"1.8E-05","AT-3":"2.4E-05","AT-4":"N.D."},{"Metabolite":"1,2-Dipalmitoyl-glycero-3-phosphoethanolamine-2","WC-1":"1.3E-05","WC-2":"2.0E-05","WC-3":"2.7E-05","WC-4":"1.3E-05","WT-1":"1.5E-05","WT-2":"2.3E-05","WT-3":"2.4E-05","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"N.D.","AC-4":"N.D.","AT-1":"2.2E-05","AT-2":"1.6E-05","AT-3":"1.4E-05","AT-4":"N.D."},{"Metabolite":"1,2-Distearoyl-glycero-3-phosphocholine","WC-1":"9.8E-05","WC-2":"8.8E-05","WC-3":"1.2E-04","WC-4":"3.9E-05","WT-1":"2.0E-04","WT-2":"2.4E-04","WT-3":"2.0E-04","WT-4":"N.D.","AC-1":"1.1E-04","AC-2":"5.5E-05","AC-3":"4.2E-05","AC-4":"7.1E-05","AT-1":"1.4E-04","AT-2":"N.D.","AT-3":"7.1E-05","AT-4":"7.6E-05"},{"Metabolite":"1-Myristoyl-glycero-3-phosphocholine","WC-1":"N.D.","WC-2":"2.7E-05","WC-3":"2.8E-05","WC-4":"6.5E-05","WT-1":"5.7E-05","WT-2":"4.9E-05","WT-3":"N.D.","WT-4":"N.D.","AC-1":"N.D.","AC-2":"N.D.","AC-3":"6.2E-05","AC-4":"1.2E-04","AT-1":"7.3E-05","AT-2":"N.D.","AT-3":"4.8E-05","AT-4":"N.D."},{"Metabolite":"15(S)-HETE","WC-1":"2.7E-05","WC-2":"2.1E-05","WC-3":"1.3E-05","WC-4":"2.4E-05","WT-1":"1.3E-05","WT-2":"2.3E-05","WT-3":"1.7E-05","WT-4":"2.5E-04","AC-1":"3.2E-05","AC-2":"4.1E-05","AC-3":"8.7E-05","AC-4":"9.5E-05","AT-1":"3.4E-05","AT-2":"3.8E-05","AT-3":"3.7E-05","AT-4":"2.2E-05"},{"Metabolite":"17α-Hydroxyprogesterone-1　Deoxycorticosterone-1","WC-1":"3.1E-05","WC-2":"4.9E-05","WC-3":"N.D.","WC-4":"2.3E-05","WT-1":"2.5E-05","WT-2":"4.3E-05","WT-3":"4.2E-05","WT-4":"3.1E-05","AC-1":"2.1E-05","AC-2":"6.1E-05","AC-3":"7.3E-05","AC-4":"5.4E-05","AT-1":"3.0E-05","AT-2":"1.9E-05","AT-3":"N.D.","AT-4":"5.8E-05"},{"Metabolite":"17α-Hydroxyprogesterone-2　Deoxycorticosterone-2　5β-pregnane-3α,21-diol-11,20-dione","WC-1":"4.5E-04","WC-2":"3.7E-04","WC-3":"8.6E-05","WC-4":"3.2E-04","WT-1":"2.6E-04","WT-2":"2.5E-04","WT-3":"6.8E-05","WT-4":"5.4E-04","AC-1":"3.7E-04","AC-2":"2.1E-04","AC-3":"2.7E-04","AC-4":"3.8E-04","AT-1":"3.9E-04","AT-2":"3.2E-04","AT-3":"6.1E-05","AT-4":"1.2E-04"},{"Metabolite":"17α-Hydroxyprogesterone-3","WC-1":"2.1E-05","WC-2":"3.8E-05","WC-3":"2.3E-05","WC-4":"2.1E-05","WT-1":"N.D.","WT-2":"3.4E-05","WT-3":"6.6E-05","WT-4":"3.5E-05","AC-1":"N.D.","AC-2":"2.5E-05","AC-3":"4.2E-05","AC-4":"5.0E-05","AT-1":"2.9E-05","AT-2":"N.D.","AT-3":"2.0E-05","AT-4":"4.5E-05"},{"Metabolite":"2-Arachidonoylglycerol-1","WC-1":"1.2E-05","WC-2":"N.D.","WC-3":"5.7E-05","WC-4":"1.7E-05","WT-1":"N.D.","WT-2":"N.D.","WT-3":"N.D.","WT-4":"3.2E-05","AC-1":"N.D.","AC-2":"5.0E-05","AC-3":"N.D.","AC-4":"N.D.","AT-1":"4.3E-05","AT-2":"3.8E-05","AT-3":"N.D.","AT-4":"2.4E-05"},{"Metabolite":"2-Arachidonoylglycerol-2","WC-1":"4.2E-04","WC-2":"7.1E-04","WC-3":"9.5E-04","WC-4":"5.5E-04","WT-1":"8.5E-04","WT-2":"7.0E-04","WT-3":"6.4E-04","WT-4":"7.5E-04","AC-1":"7.1E-04","AC-2":"7.6E-04","AC-3":"4.2E-04","AC-4":"4.5E-04","AT-1":"7.4E-04","AT-2":"1.0E-03","AT-3":"N.D.","AT-4":"9.7E-04"},{"Metabolite":"2-Hydroxytetradecanoic acid-1","WC-1":"1.1E-05","WC-2":"N.D.","WC-3":"N.D.","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"6.2E-06","WT-4":"5.3E-06","AC-1":"N.D.","AC-2":"8.6E-06","AC-3":"N.D.","AC-4":"N.D.","AT-1":"N.D.","AT-2":"9.3E-06","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"2-Hydroxytetradecanoic acid-2　3-Hydroxytetradecanoic acid-2","WC-1":"1.9E-05","WC-2":"1.3E-05","WC-3":"9.1E-06","WC-4":"6.6E-06","WT-1":"9.6E-06","WT-2":"9.3E-06","WT-3":"1.8E-05","WT-4":"2.4E-05","AC-1":"1.4E-05","AC-2":"1.3E-05","AC-3":"1.6E-05","AC-4":"7.6E-06","AT-1":"1.2E-05","AT-2":"1.7E-05","AT-3":"3.7E-06","AT-4":"1.2E-05"},{"Metabolite":"20α-Hydroxycholesterol","WC-1":"6.1E-05","WC-2":"1.0E-04","WC-3":"5.2E-05","WC-4":"N.D.","WT-1":"N.D.","WT-2":"N.D.","WT-3":"5.2E-05","WT-4":"4.9E-05","AC-1":"N.D.","AC-2":"1.2E-04","AC-3":"3.7E-05","AC-4":"N.D.","AT-1":"6.4E-05","AT-2":"4.5E-05","AT-3":"N.D.","AT-4":"2.7E-05"},{"Metabolite":"20α-Hydroxyprogesterone","WC-1":"2.3E-04","WC-2":"N.D.","WC-3":"N.D.","WC-4":"2.1E-04","WT-1":"2.0E-04","WT-2":"2.3E-05","WT-3":"N.D.","WT-4":"2.4E-04","AC-1":"4.8E-04","AC-2":"1.1E-04","AC-3":"2.2E-05","AC-4":"6.0E-04","AT-1":"1.4E-04","AT-2":"1.8E-04","AT-3":"N.D.","AT-4":"2.9E-05"},{"Metabolite":"21-Deoxycortisol-2","WC-1":"4.6E-05","WC-2":"1.6E-04","WC-3":"1.6E-04","WC-4":"6.6E-05","WT-1":"6.7E-05","WT-2":"1.3E-04","WT-3":"1.5E-04","WT-4":"3.5E-05","AC-1":"4.9E-05","AC-2":"1.0E-04","AC-3":"2.3E-04","AC-4":"5.1E-05","AT-1":"7.3E-05","AT-2":"7.4E-05","AT-3":"1.8E-04","AT-4":"1.5E-04"},{"Metabolite":"22-Hydroxycholesterol","WC-1":"N.D.","WC-2":"8.3E-05","WC-3":"N.D.","WC-4":"N.D.","WT-1":"7.7E-05","WT-2":"N.D.","WT-3":"N.D.","WT-4":"1.2E-04","AC-1":"N.D.","AC-2":"1.6E-04","AC-3":"N.D.","AC-4":"N.D.","AT-1":"6.3E-05","AT-2":"3.7E-05","AT-3":"N.D.","AT-4":"N.D."},{"Metabolite":"3-Hydroxytetradecanoic acid-1","WC-1":"1.5E-05","WC-2":"3.2E-05","WC-3":"3.3E-05","WC-4":"1.9E-05","WT-1":"2.0E-05","WT-2":"2.2E-05","WT-3":"3.5E-05","WT-4":"6.2E-05","AC-1":"3.2E-05","AC-2":"3.6E-05","AC-3":"1.1E-05","AC-4":"1.7E-05","AT-1":"4.1E-05","AT-2":"3.0E-05","AT-3":"1.6E-05","AT-4":"1.7E-05"},{"Metabolite":"4-Androstene-3,17-dione","WC-1":"3.4E-05","WC-2":"8.4E-05","WC-3":"3.7E-05","WC-4":"4.7E-05","WT-1":"4.6E-05","WT-2":"4.6E-05","WT-3":"4.7E-05","WT-4":"5.2E-05","AC-1":"5.7E-05","AC-2":"7.9E-05","AC-3":"4.0E-05","AC-4":"3.9E-05","AT-1":"4.6E-05","AT-2":"3.8E-05","AT-3":"3.9E-05","AT-4":"4.2E-05"},{"Metabolite":"5-Methoxyindoleacetic 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CID":"68051","HMDB ID":"HMDB0030041","m/z":"413.264","MT/RT":"14.39"},{"Metabolite":"Lutein","PubChem CID":"5281243","HMDB ID":"HMDB0003233","m/z":"551.438","MT/RT":"14.76"},{"Metabolite":"Myristic acid","PubChem CID":"11005","HMDB ID":"HMDB0000806","m/z":"227.202","MT/RT":"14.03"},{"Metabolite":"N-Acetylsphingosine","PubChem CID":"5497136","HMDB ID":"","m/z":"342.294","MT/RT":"13.57"},{"Metabolite":"Nervonic acid","PubChem CID":"5281120","HMDB ID":"HMDB0002368","m/z":"365.342","MT/RT":"16.35"},{"Metabolite":"Oleic acid","PubChem CID":"445639","HMDB ID":"HMDB0000207","m/z":"281.248","MT/RT":"14.85"},{"Metabolite":"Oleoyl ethanolamide-1　AEA(18:1)-1","PubChem CID":"5283454　0","HMDB ID":"HMDB0002088　","m/z":"326.304","MT/RT":"14.04"},{"Metabolite":"Oleoyl ethanolamide-2　AEA(18:1)-2","PubChem CID":"5283454　0","HMDB ID":"HMDB0002088　","m/z":"326.305","MT/RT":"14.33"},{"Metabolite":"Palmitic acid","PubChem CID":"985","HMDB ID":"HMDB0000220","m/z":"255.233","MT/RT":"14.75"},{"Metabolite":"Palmitoleic acid","PubChem CID":"445638","HMDB ID":"HMDB0003229","m/z":"253.218","MT/RT":"14.18"},{"Metabolite":"Palmitoylcarnitine","PubChem CID":"11953816","HMDB ID":"HMDB0000222","m/z":"400.344","MT/RT":"11.71"},{"Metabolite":"Palmitoylethanolamide","PubChem CID":"4671","HMDB ID":"HMDB0002100","m/z":"300.288","MT/RT":"13.89"},{"Metabolite":"Pentadecanoic acid","PubChem CID":"13849","HMDB ID":"HMDB0000826","m/z":"241.218","MT/RT":"14.41"},{"Metabolite":"Phytosphingosine","PubChem CID":"122121","HMDB ID":"HMDB0004610","m/z":"318.298","MT/RT":"11.08"},{"Metabolite":"Progesterone","PubChem CID":"5994","HMDB ID":"HMDB0001830","m/z":"315.23","MT/RT":"11.15"},{"Metabolite":"Prostaglandin D2","PubChem CID":"448457","HMDB ID":"HMDB0001403","m/z":"370.257","MT/RT":"10.36"},{"Metabolite":"Quercetin","PubChem CID":"5280343","HMDB ID":"HMDB0005794","m/z":"301.037","MT/RT":"8.93"},{"Metabolite":"Retinol-1","PubChem CID":"445354","HMDB ID":"HMDB0000305","m/z":"269.226","MT/RT":"13.76"},{"Metabolite":"Retinol-2","PubChem CID":"445354","HMDB ID":"HMDB0000305","m/z":"269.227","MT/RT":"14.03"},{"Metabolite":"Retinol-3","PubChem CID":"445354","HMDB ID":"HMDB0000305","m/z":"269.227","MT/RT":"13.92"},{"Metabolite":"Riboflavin","PubChem CID":"493570","HMDB ID":"HMDB0000244","m/z":"377.145","MT/RT":"6.08"},{"Metabolite":"Ricinoleic acid-1","PubChem CID":"643684","HMDB ID":"HMDB0034297","m/z":"297.242","MT/RT":"12.61"},{"Metabolite":"Ricinoleic acid-2","PubChem CID":"643684","HMDB ID":"HMDB0034297","m/z":"297.242","MT/RT":"12.96"},{"Metabolite":"Ricinoleic acid-3","PubChem CID":"643684","HMDB ID":"HMDB0034297","m/z":"297.243","MT/RT":"12.7"},{"Metabolite":"Sitosterol-1","PubChem CID":"222284","HMDB ID":"HMDB0000852","m/z":"397.383","MT/RT":"16.72"},{"Metabolite":"Sitosterol-2","PubChem CID":"222284","HMDB ID":"HMDB0000852","m/z":"397.385","MT/RT":"16.56"},{"Metabolite":"Sphinganine","PubChem CID":"91486","HMDB ID":"HMDB0000269","m/z":"302.309","MT/RT":"11.36"},{"Metabolite":"Sphingomyelin(d18:1/16:0)","PubChem CID":"9939941","HMDB ID":"HMDB0010169","m/z":"703.58","MT/RT":"16.31"},{"Metabolite":"Sphingomyelin(d18:1/18:0)","PubChem CID":"6453725","HMDB ID":"HMDB0001348","m/z":"731.598","MT/RT":"16.41"},{"Metabolite":"Sphingosine","PubChem CID":"5280335","HMDB ID":"HMDB0000252","m/z":"300.288","MT/RT":"11.18"},{"Metabolite":"Stearic acid","PubChem CID":"5281","HMDB ID":"HMDB0000827","m/z":"284.268","MT/RT":"15.38"},{"Metabolite":"Stearidonic acid","PubChem CID":"5312508","HMDB ID":"HMDB0006547","m/z":"275.2","MT/RT":"13.58"},{"Metabolite":"Stearoyl ethanolamide","PubChem CID":"27902","HMDB ID":"HMDB0013078","m/z":"328.321","MT/RT":"14.61"},{"Metabolite":"Stigmasterol","PubChem CID":"5280794","HMDB ID":"HMDB0000937","m/z":"395.368","MT/RT":"16.26"},{"Metabolite":"Taurochenodeoxycholic acid","PubChem CID":"387316","HMDB ID":"HMDB0000951","m/z":"498.287","MT/RT":"12.68"},{"Metabolite":"Taurocholic acid","PubChem CID":"6675","HMDB ID":"HMDB0000036","m/z":"515.29","MT/RT":"11.82"},{"Metabolite":"Taurodeoxycholic acid","PubChem CID":"2733768","HMDB ID":"HMDB0000896","m/z":"498.288","MT/RT":"12.99"},{"Metabolite":"Taurolithocholic acid","PubChem CID":"439763","HMDB ID":"HMDB0000722","m/z":"482.295","MT/RT":"13.66"},{"Metabolite":"Tauroursodeoxycholic acid","PubChem CID":"9848818","HMDB ID":"HMDB0000874","m/z":"498.287","MT/RT":"11.63"},{"Metabolite":"Testosterone","PubChem CID":"6013","HMDB ID":"HMDB0000234","m/z":"289.213","MT/RT":"10.17"},{"Metabolite":"Testosterone acetate","PubChem CID":"92145","HMDB ID":"HMDB0062780","m/z":"331.23","MT/RT":"11.54"},{"Metabolite":"Thyroxine","PubChem CID":"5819","HMDB ID":"HMDB0000248","m/z":"777.681","MT/RT":"9.82"},{"Metabolite":"Trilaurin","PubChem CID":"10851","HMDB ID":"HMDB0011188","m/z":"656.587","MT/RT":"17.81"},{"Metabolite":"Ursodeoxycholic acid","PubChem CID":"31401","HMDB ID":"HMDB0000946","m/z":"391.284","MT/RT":"11.11"},{"Metabolite":"Zeaxanthin","PubChem CID":"5280899","HMDB ID":"HMDB0002789","m/z":"569.425","MT/RT":"15.07"},{"Metabolite":"α-Tocopherol","PubChem CID":"14985","HMDB ID":"HMDB0001893","m/z":"431.388","MT/RT":"16.41"},{"Metabolite":"α-Tocopherol acetate","PubChem CID":"86472","HMDB ID":"HMDB0034227","m/z":"490.425","MT/RT":"16.68"},{"Metabolite":"β-Cryptoxanthin-1","PubChem CID":"5281235","HMDB ID":"HMDB0033844","m/z":"553.433","MT/RT":"16.98"},{"Metabolite":"β-Cryptoxanthin-2","PubChem CID":"5281235","HMDB ID":"HMDB0033844","m/z":"553.436","MT/RT":"16.74"},{"Metabolite":"β-Estradiol　17α-Estradiol","PubChem CID":"5757　68570","HMDB ID":"HMDB0000151　HMDB0000429","m/z":"273.189","MT/RT":"10.06"},{"Metabolite":"γ-Tocopherol","PubChem CID":"92729","HMDB ID":"HMDB0001492","m/z":"417.369","MT/RT":"16.22"}]
}

}