{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002179","ANALYSIS_ID":"AN003568","VERSION":"1","CREATED_ON":"May 26, 2022, 5:52 pm"},

"PROJECT":{"PROJECT_TITLE":"Impact of nitisinone on the cerebrospinal fluid metabolome of a murine model of alkaptonuria","PROJECT_SUMMARY":"Background: Nitisinone induced hypertyrosinaemia is well documented in Alkaptonuria (AKU), and there is uncertainty over whether it may contribute to a decline in cognitive function and or mood by altering neurotransmitter metabolism. The aim of this work was to evaluate the impact of nitisinone on the cerebrospinal fluid (CSF) metabolome in a murine model of AKU, with a view to providing additional insight into metabolic changes that occur following treatment with nitisinone. Methods: 17 CSF samples were collected from BALB/c Hgd-/-mice (n=8, treated with nitisinone – 4 mg/L and n=9, no treatment). Samples were diluted 1:1 with deionised water and analysed using a 1290 Infinity II liquid chromatography system coupled to a 6550 quadrupole time-of-flight mass spectrometry (Agilent, Cheadle, UK). Raw data were processed using a targeted feature extraction algorithm and an established in-house accurate mass retention time database. Matched entities (±10 ppm theoretical accurate mass and ±0.3 minutes retention time window) were filtered based on their frequency and variability. Experimental groups were compared using a moderated t-test with Benjamini-Hochberg false-discovery rate adjustment. Results: Tyrosine, acetyl-tyrosine, γ-glutamyl-tyrosine, p-hydroxyphenylacetic acid and 3-(4-hydroxyphenyl)lactic acid were shown to increase in abundance (log2 fold change 2.6-6.9, 3/5 were significant p<0.05) in the mice that received nitisinone. Several other metabolites of interest were matched but no significant differences were observed, including the aromatic amino acids phenylalanine and tryptophan, and monoamine metabolites adrenaline, 3-methoxy-4-hydroxyphenylglycol and octopamine. Conclusions: Evaluation of the CSF metabolome of a murine model of AKU showed a significant difference in the abundance of a limited number of metabolites. None of these have been reported in CSF from a murine model of AKU previously. Moreover this study confirms that some monoamine metabolites do not appear to be altered following nitisinone therapy.","INSTITUTE":"University of Liverpool Institute of Life Course & Medical Sciences","LAST_NAME":"Davison","FIRST_NAME":"Andrew","ADDRESS":"1. Department of Clinical Biochemistry and Metabolic Medicine, Liverpool Clinical Laboratories, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK; 2. Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK 3. School of Exercise Science, Liverpool John Moores University, Liverpool, UK","EMAIL":"andrew.davison@liverpoolft.nhs.uk","PHONE":"0151 706 4011","CONTRIBUTORS":"Davison AS1,2,*, Norman BP2, Sutherland H2,3, Milan AM1,2, Jarvis JC3, Gallagher JA2, Ranganath LR1,2"},

"STUDY":{"STUDY_TITLE":"Impact of nitisinone on the cerebrospinal fluid metabolome of a murine model of alkaptonuria","STUDY_SUMMARY":"Background: Nitisinone induced hypertyrosinaemia is well documented in Alkaptonuria (AKU), and there is uncertainty over whether it may contribute to a decline in cognitive function and or mood by altering neurotransmitter metabolism. The aim of this work was to evaluate the impact of nitisinone on the cerebrospinal fluid (CSF) metabolome in a murine model of AKU, with a view to providing additional insight into metabolic changes that occur following treatment with nitisinone. Methods: 17 CSF samples were collected from BALB/c Hgd-/-mice (n=8, treated with nitisinone – 4 mg/L and n=9, no treatment). Samples were diluted 1:1 with deionised water and analysed using a 1290 Infinity II liquid chromatography system coupled to a 6550 quadrupole time-of-flight mass spectrometry (Agilent, Cheadle, UK). Raw data were processed using a targeted feature extraction algorithm and an established in-house accurate mass retention time database. Matched entities (±10 ppm theoretical accurate mass and ±0.3 minutes retention time window) were filtered based on their frequency and variability. Experimental groups were compared using a moderated t-test with Benjamini-Hochberg false-discovery rate adjustment. Results: Tyrosine, acetyl-tyrosine, γ-glutamyl-tyrosine, p-hydroxyphenylacetic acid and 3-(4-hydroxyphenyl)lactic acid were shown to increase in abundance (log2 fold change 2.6-6.9, 3/5 were significant p<0.05) in the mice that received nitisinone. Several other metabolites of interest were matched but no significant differences were observed, including the aromatic amino acids phenylalanine and tryptophan, and monoamine metabolites adrenaline, 3-methoxy-4-hydroxyphenylglycol and octopamine. Conclusions: Evaluation of the CSF metabolome of a murine model of AKU showed a significant difference in the abundance of a limited number of metabolites. None of these have been reported in CSF from a murine model of AKU previously. Moreover this study confirms that some monoamine metabolites do not appear to be altered following nitisinone therapy.","INSTITUTE":"University of Liverpool Institute of Life Course & Medical Sciences","LAST_NAME":"Davison","FIRST_NAME":"Andrew","ADDRESS":"1. Department of Clinical Biochemistry and Metabolic Medicine, Liverpool Clinical Laboratories, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK; 2. Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK 3. School of Exercise Science, Liverpool John Moores University, Liverpool, UK","EMAIL":"andrew.davison@liverpoolft.nhs.uk","PHONE":"0151 706 4011","NUM_GROUPS":"2","TOTAL_SUBJECTS":"17"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"Hgd81.1 + Nitisinone NEG",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_+ NTBC_81.1_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd81.2 + Nitisinone NEG",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_+ NTBC_81.2_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd81.3 + Nitisinone NEG",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_+ NTBC_81.3_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd82.1 + Nitisinone NEG",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_+ NTBC_82.1_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd82.2 + Nitisinone NEG",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_+ NTBC_82.2_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd83.1 + Nitisinone NEG",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_+ NTBC_83.1_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd83.2 - No treatment NEG",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_+ NTBC_83.2_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd80.3 - No treatment NEG",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_80.3_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd80.4 - No treatment NEG",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_80.4_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd81.4 - No treatment NEG",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_81.4_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd81.5 - No treatment NEG",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_81.5_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd81.6 - No treatment NEG",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_81.6_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd82.3 - No treatment NEG",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_82.3_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd82.4 - No treatment NEG",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_82.4_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd83.3 - No treatment NEG",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_83.3_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd83.4 - No treatment NEG",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"NEG_AKU_83.4_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd80.2 + Nitisinone POS",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_+ NTBC_80.2_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd81.1 + Nitisinone POS",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_+ NTBC_81.1_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd81.2 + Nitisinone POS",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_+ NTBC_81.2_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd81.3 + Nitisinone POS",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_+ NTBC_81.3_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd82.1 + Nitisinone POS",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_+ NTBC_82.1_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd82.2 + Nitisinone POS",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_+ NTBC_82.2_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd83.1 + Nitisinone POS",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_+ NTBC_83.1_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd83.2 - No treatment POS",
"Factors":{"Treatment group":"Nitisinone"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_+ NTBC_83.2_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd80.3 - No treatment POS",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_80.3_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd80.4 - No treatment POS",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_80.4_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd81.4 - No treatment POS",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_81.4_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd81.5 - No treatment POS",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_81.5_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd81.6 - No treatment POS",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_81.6_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd82.3 - No treatment POS",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_82.3_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd82.4 - No treatment POS",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_82.4_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd83.3 - No treatment POS",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_83.3_CSF"}
},
{
"Subject ID":"-",
"Sample ID":"Hgd83.4 - No treatment POS",
"Factors":{"Treatment group":"No Treatment (control)"},
"Additional sample data":{"RAW_FILE_NAME":"POS_AKU_83.4_CSF"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"A murine model of AKU was used for all experiments as described previously (Preston et al., 2014). Seventeen BALB/c Hgd-/- mice (Figure 5 for age and gender) were included in this study, 8 mice were administered nitisinone (4 mg/L) through their drinking water for 6 days, the remaining 9 mice received no nitisinone. All animals were housed in air conditioned rooms (with a 12 h dark/light cycle) at 20 °C and 53 % humidity, with access to food and water ad libitum at Liverpool John Moores University. All animal experiments complied with the ARRIVE guidelines and were carried out in accordance with the U.K. Animals (Scientific Procedures) Act, 1986 and associated guidelines, EU Directive 2010/63/EU for animal experiments. All mice were culled by carbon dioxide asphyxiation and CSF was removed from the cisterna magna following the puncture technique of Liu et al. (56), with some modifications. The cisterna magna was exposed by dissecting skin and overlaying muscles. Cauterisation was used to dry up any bleeding from surrounding tissues. A pulled glass pipette with an internal diameter of ~0.4 mm was attached to silicone tubing and connected to a 1 mL syringe with a 19 g needle. The tip of the glass pipette was used to puncture the membrane and held still just below the membrane by 1 person. Through a double-headed microscope a second person then used the 1 mL syringe to apply gentle pressure to encourage the CSF to flow up the capillary tube. Only clear CSF samples (i.e. non blood stained) were collected. Once collected CSF samples were transferred to clear Eppendorf tubes and stored at -80 °C until analysis. Samples were not acidified. The same glass pipette was used to collect CSF from each animal, and was washed with pure water between each animal.","SAMPLE_TYPE":"CSF"},

"TREATMENT":{"TREATMENT_SUMMARY":"9 mice control 8 mice received 4 mg/L nitisinone for 6 days in drinking water"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Murine CSF samples were prepared by diluting 2 µL CSF with 2 µL deionized water (DIRECT-Q 3UV Millipore water purification system). CSF samples were pipetted directly into a 150 µL glass insert with polymer feet, which sat in a 2 mL amber screw vial (Agilent, Cheadle, UK). These vials were used to ensure maximal recovery of sample. Deionised water was also added directly to the glass insert, and mixed with the CSF sample using a pipette. The glass vials were centrifuged at 600 rpm for 10 min to ensure the diluted sample was at the bottom of the vial for sampling. 1 µL of diluted CSF was analysed in negative and positive polarities, respectively."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Liquid chromatography (LC) was performed on an Agilent 1290 Infinity II LC system. An Atlantis dC18 column (3.0x100mm, 3µm, Waters, UK) was maintained at 60°C with a flow rate of 0.4mL/min. Mobile phases were (A) water and (B) methanol both containing 5mmol/L ammonium formate and 0.1% formic acid. The elution gradient started at 5% mobile phase B at 0-1 min increasing linearly to 100% B by 12 min, held at 100% B until 14 min, returning to 95% A for 5 min to recondition the column. Injection volume was 1µL.","CHROMATOGRAPHY_TYPE":"Reversed phase","INSTRUMENT_NAME":"Agilent Infinity II","COLUMN_NAME":"Atlantis dC18 column (3.0x100mm, 3µm, Waters, UK)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 6550 QTOF","INSTRUMENT_TYPE":"Triple quadrupole","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"Quadrupole time-of-flight mass spectrometry (QTOF-MS) conditions An Agilent 6550 QTOF-MS equipped with a dual jet stream electrospray ionisation source was operated in 2GHz mode, over the mass range of 50-1700, in negative and positive polarities. A reference mass correction solution was continually infused at a flow rate of 0.5 mL/min via an external isocratic pump (Agilent, UK) for constant mass correction (see Preparation of reference mass correction solution). Capillary and fragmentor voltages were 4000 V and 380 V, respectively. Desolvation gas temperature was 200 °C with flow rate at 15 L/min. The sheath gas temperature was 300 °C with flow rate at 12 L/min and nebulizer pressure was 40 psi and nozzle voltage 1000 V. Data acquisition rate was 3 spectra/s. Preparation of reference mass correction solution Reference mass correction solution was prepared in 95:5 methanol:water containing 5 mmol/L purine (CAS No. 120-73-0), 100 mmol/L trifluoroacetic acid ammonium salt (TFA, CAS No. 3336-58-1) and 2.5 mmol/L hexakis(1H, 1H, 3H-tetrafluoropropoxy)phosphazine (HP-0921, CAS No. 58943-98-9) (Agilent, Cheadle, UK). Reference ions monitored were: purine (m/z 121.0509) and HP-0921 (m/z 922.0098) (positive polarity) and TFA (m/z 112.9856), purine (m/z 119.0363) and HP-0921 (HP-0921 + formate adduct: m/z 966.0007) (negative polarity). Data acquisition and handling parameters Data were acquired using Acquisition (Build 06.00, Agilent, Cheadle, UK). Quality checks and processing of raw data files (Agilent ‘.d’ files) were performed with Qualitative Analysis software (Build 07.00, Agilent, Cheadle, UK). Extracted ion chromatograms of reference masses were performed to check mass accuracy remained <5 ppm throughout the run and that the reference ion signal did not drop out during the chromatographic run. In addition, to check chromatographic reproducibility binary pump pressure curves for injections across each analytical sequence were overlaid. Mass accuracy and chromatographic reproducibility were acceptable for all experiments performed. Acquired profiling sample data were mined for signals against an established in-house AMRT database of compounds (contains theoretical accurate mass, measured retention time, and empirical formula for 469 intermediary metabolites, MW 72-785) using ‘targeted feature extraction’ with Profinder software (Build 08.00, Agilent, Cheadle, UK). Targeted feature extraction uses the molecular formulae from the AMRT database to extract and group spectral signals (i.e. adducts, isotopes and multimers) that correspond to individual database compounds. Feature extraction employed a window of theoretical accurate mass ±10 ppm and database retention time ±0.3 min. Allowed species were: H+, Na+ and NH4+ (positive polarity) and H- and CHO2- (negative polarity). Dimers were allowed for both polarities. Charge state range was 1-2. Data files were then exported from Profinder as ‘.CEF’ files as a whole batch for each profiling experiment and imported to Mass Profiler Professional (MPP) software for statistical analysis (Build 14.5, Agilent, Cheadle, UK)."},

"MS_METABOLITE_DATA":{
"Units":"area",

"Data":[{"Metabolite":"L-Histidine","Hgd80.2 + Nitisinone POS":"78933","Hgd81.1 + Nitisinone POS":"72314","Hgd81.2 + Nitisinone POS":"64514","Hgd81.3 + Nitisinone POS":"36100","Hgd82.1 + Nitisinone POS":"55730","Hgd82.2 + Nitisinone POS":"49207","Hgd83.1 + Nitisinone POS":"62860","Hgd83.2 - No treatment POS":"64484","Hgd80.3 - No treatment POS":"47029","Hgd80.4 - No treatment POS":"57276","Hgd81.4 - No treatment POS":"46393","Hgd81.5 - No treatment POS":"45511","Hgd81.6 - No treatment POS":"73233","Hgd82.3 - No treatment POS":"54586","Hgd82.4 - No treatment POS":"55459","Hgd83.3 - No treatment POS":"70186","Hgd83.4 - No treatment POS":"64495"},{"Metabolite":"Inosine","Hgd80.2 + Nitisinone POS":"3903310","Hgd81.1 + Nitisinone POS":"4005959","Hgd81.2 + Nitisinone POS":"3069856","Hgd81.3 + Nitisinone POS":"3496044","Hgd82.1 + Nitisinone POS":"4261473","Hgd82.2 + Nitisinone POS":"3752630","Hgd83.1 + Nitisinone POS":"4043093","Hgd83.2 - No treatment POS":"4188349","Hgd80.3 - No treatment POS":"3794904","Hgd80.4 - No treatment POS":"3774884","Hgd81.4 - No treatment POS":"3899201","Hgd81.5 - No treatment POS":"3892178","Hgd81.6 - No treatment POS":"3670710","Hgd82.3 - No treatment POS":"3659707","Hgd82.4 - No treatment POS":"3958599","Hgd83.3 - No treatment POS":"4380851","Hgd83.4 - No treatment POS":"4397641"},{"Metabolite":"Adipic acid","Hgd80.2 + Nitisinone POS":"139999","Hgd81.1 + Nitisinone POS":"71929","Hgd81.2 + Nitisinone POS":"45803","Hgd81.3 + Nitisinone POS":"351712","Hgd82.1 + Nitisinone POS":"144891","Hgd82.2 + Nitisinone POS":"76400","Hgd83.1 + Nitisinone POS":"138106","Hgd83.2 - No treatment POS":"688082","Hgd80.3 - No treatment POS":"105986","Hgd80.4 - No treatment POS":"80090","Hgd81.4 - No treatment POS":"111599","Hgd81.5 - No treatment POS":"150378","Hgd81.6 - No treatment POS":"85783","Hgd82.3 - No treatment POS":"246463","Hgd82.4 - No treatment POS":"245567","Hgd83.3 - No treatment POS":"118607","Hgd83.4 - No treatment POS":"225067"},{"Metabolite":"Sarcosine","Hgd80.2 + Nitisinone POS":"178538","Hgd81.1 + Nitisinone POS":"163956","Hgd81.2 + Nitisinone POS":"141587","Hgd81.3 + Nitisinone POS":"160669","Hgd82.1 + Nitisinone POS":"254977","Hgd82.2 + Nitisinone POS":"180632","Hgd83.1 + Nitisinone POS":"166993","Hgd83.2 - No treatment POS":"188636","Hgd80.3 - No treatment POS":"163012","Hgd80.4 - No treatment POS":"162463","Hgd81.4 - No treatment POS":"148506","Hgd81.5 - No treatment POS":"178385","Hgd81.6 - No treatment POS":"200702","Hgd82.3 - No treatment POS":"162211","Hgd82.4 - No treatment POS":"179038","Hgd83.3 - No treatment POS":"185995","Hgd83.4 - No treatment POS":"173257"},{"Metabolite":"6-Deoxy-L-galactose","Hgd80.2 + Nitisinone POS":"889697","Hgd81.1 + Nitisinone POS":"1251635","Hgd81.2 + Nitisinone POS":"660939","Hgd81.3 + Nitisinone POS":"687862","Hgd82.1 + Nitisinone POS":"397994","Hgd82.2 + Nitisinone POS":"533422","Hgd83.1 + Nitisinone POS":"782823","Hgd83.2 - No treatment POS":"683651","Hgd80.3 - No treatment POS":"1177064","Hgd80.4 - No treatment POS":"1094671","Hgd81.4 - No treatment POS":"839623","Hgd81.5 - No treatment POS":"978886","Hgd81.6 - No treatment POS":"929904","Hgd82.3 - No treatment POS":"1038672","Hgd82.4 - No treatment POS":"970744","Hgd83.3 - No treatment POS":"1280665","Hgd83.4 - No treatment POS":"1149318"},{"Metabolite":"L-Pipecolic acid","Hgd80.2 + Nitisinone POS":"49302","Hgd81.1 + Nitisinone POS":"21919","Hgd81.2 + Nitisinone POS":"20078","Hgd81.3 + Nitisinone POS":"28054","Hgd82.1 + Nitisinone POS":"106503","Hgd82.2 + Nitisinone POS":"69113","Hgd83.1 + Nitisinone POS":"19099","Hgd83.2 - No treatment POS":"17758","Hgd80.3 - No treatment POS":"38017","Hgd80.4 - No treatment POS":"48733","Hgd81.4 - No treatment POS":"35146","Hgd81.5 - No treatment POS":"57446","Hgd81.6 - No treatment POS":"34751","Hgd82.3 - No treatment POS":"65513","Hgd82.4 - No treatment POS":"69077","Hgd83.3 - No treatment POS":"27954","Hgd83.4 - No treatment POS":"26177"},{"Metabolite":"Ethylmalonic acid","Hgd80.2 + Nitisinone POS":"8950","Hgd81.1 + Nitisinone POS":"6971","Hgd81.2 + Nitisinone POS":"6802","Hgd81.3 + Nitisinone POS":"13787","Hgd82.1 + Nitisinone POS":"12484","Hgd82.2 + Nitisinone POS":"16061","Hgd83.1 + Nitisinone POS":"7428","Hgd83.2 - No treatment POS":"14577","Hgd80.3 - No treatment POS":"7816","Hgd80.4 - No treatment POS":"11368","Hgd81.4 - No treatment POS":"9340","Hgd81.5 - No treatment POS":"14080","Hgd81.6 - No treatment POS":"7236","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"11472","Hgd83.3 - No treatment POS":"10403","Hgd83.4 - No treatment POS":"12474"},{"Metabolite":"D-(-)-Lyxose","Hgd80.2 + Nitisinone POS":"124071","Hgd81.1 + Nitisinone POS":"153992","Hgd81.2 + Nitisinone POS":"120694","Hgd81.3 + Nitisinone POS":"127395","Hgd82.1 + Nitisinone POS":"65086","Hgd82.2 + Nitisinone POS":"90135","Hgd83.1 + Nitisinone POS":"144368","Hgd83.2 - No treatment POS":"129393","Hgd80.3 - No treatment POS":"205460","Hgd80.4 - No treatment POS":"167131","Hgd81.4 - No treatment POS":"138531","Hgd81.5 - No treatment POS":"116688","Hgd81.6 - No treatment POS":"117816","Hgd82.3 - No treatment POS":"82946","Hgd82.4 - No treatment POS":"153443","Hgd83.3 - No treatment POS":"160433","Hgd83.4 - No treatment POS":"162398"},{"Metabolite":"Theobromine","Hgd80.2 + Nitisinone POS":"37255","Hgd81.1 + Nitisinone POS":"17965","Hgd81.2 + Nitisinone POS":"19980","Hgd81.3 + Nitisinone POS":"10385","Hgd82.1 + Nitisinone POS":"21625","Hgd82.2 + Nitisinone POS":"10307","Hgd83.1 + Nitisinone POS":"6134","Hgd83.2 - No treatment POS":"11392","Hgd80.3 - No treatment POS":"24414","Hgd80.4 - No treatment POS":"11825","Hgd81.4 - No treatment POS":"18292","Hgd81.5 - No treatment POS":"28486","Hgd81.6 - No treatment POS":"26422","Hgd82.3 - No treatment POS":"6476","Hgd82.4 - No treatment POS":"19602","Hgd83.3 - No treatment POS":"12037","Hgd83.4 - No treatment POS":"14662"},{"Metabolite":"Hippuric acid","Hgd80.2 + Nitisinone POS":"39405","Hgd81.1 + Nitisinone POS":"10633","Hgd81.2 + Nitisinone POS":"6284","Hgd81.3 + Nitisinone POS":"6883","Hgd82.1 + Nitisinone POS":"20252","Hgd82.2 + Nitisinone POS":"9899","Hgd83.1 + Nitisinone POS":"3260","Hgd83.2 - No treatment POS":"13762","Hgd80.3 - No treatment POS":"18653","Hgd80.4 - No treatment POS":"12992","Hgd81.4 - No treatment POS":"4761","Hgd81.5 - No treatment POS":"75308","Hgd81.6 - No treatment POS":"20282","Hgd82.3 - No treatment POS":"5232","Hgd82.4 - No treatment POS":"16716","Hgd83.3 - No treatment POS":"10301","Hgd83.4 - No treatment POS":"13724"},{"Metabolite":"Oleic Acid","Hgd80.2 + Nitisinone POS":"35404","Hgd81.1 + Nitisinone POS":"21421","Hgd81.2 + Nitisinone POS":"50788","Hgd81.3 + Nitisinone POS":"10013","Hgd82.1 + Nitisinone POS":"16049","Hgd82.2 + Nitisinone POS":"10111","Hgd83.1 + Nitisinone POS":"32735","Hgd83.2 - No treatment POS":"29385","Hgd80.3 - No treatment POS":"29136","Hgd80.4 - No treatment POS":"65847","Hgd81.4 - No treatment POS":"31300","Hgd81.5 - No treatment POS":"35682","Hgd81.6 - No treatment POS":"44761","Hgd82.3 - No treatment POS":"56559","Hgd82.4 - No treatment POS":"47787","Hgd83.3 - No treatment POS":"37487","Hgd83.4 - No treatment POS":"28105"},{"Metabolite":"3,4-Dihydroxybenzoic acid","Hgd80.2 + Nitisinone POS":"80115","Hgd81.1 + Nitisinone POS":"58721","Hgd81.2 + Nitisinone POS":"107102","Hgd81.3 + Nitisinone POS":"102591","Hgd82.1 + Nitisinone POS":"112969","Hgd82.2 + Nitisinone POS":"96432","Hgd83.1 + Nitisinone POS":"50443","Hgd83.2 - No treatment POS":"86773","Hgd80.3 - No treatment POS":"63977","Hgd80.4 - No treatment POS":"95823","Hgd81.4 - No treatment POS":"107245","Hgd81.5 - No treatment POS":"102728","Hgd81.6 - No treatment POS":"122295","Hgd82.3 - No treatment POS":"71642","Hgd82.4 - No treatment POS":"83618","Hgd83.3 - No treatment POS":"89812","Hgd83.4 - No treatment POS":"87811"},{"Metabolite":"Kynurenine","Hgd80.2 + Nitisinone POS":"2609","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"1","Hgd82.1 + Nitisinone POS":"1","Hgd82.2 + Nitisinone POS":"1","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"1","Hgd80.3 - No treatment POS":"1","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"1","Hgd81.6 - No treatment POS":"2058","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"1","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"3442"},{"Metabolite":"Methyl jasmonate","Hgd80.2 + Nitisinone POS":"55384","Hgd81.1 + Nitisinone POS":"50979","Hgd81.2 + Nitisinone POS":"56450","Hgd81.3 + Nitisinone POS":"44666","Hgd82.1 + Nitisinone POS":"39592","Hgd82.2 + Nitisinone POS":"38396","Hgd83.1 + Nitisinone POS":"48517","Hgd83.2 - No treatment POS":"57443","Hgd80.3 - No treatment POS":"42147","Hgd80.4 - No treatment POS":"24305","Hgd81.4 - No treatment POS":"56308","Hgd81.5 - No treatment POS":"47681","Hgd81.6 - No treatment POS":"58666","Hgd82.3 - No treatment POS":"61778","Hgd82.4 - No treatment POS":"8805","Hgd83.3 - No treatment POS":"57913","Hgd83.4 - No treatment POS":"45889"},{"Metabolite":"Thiamine monophosphate","Hgd80.2 + Nitisinone POS":"11372","Hgd81.1 + Nitisinone POS":"7958","Hgd81.2 + Nitisinone POS":"11377","Hgd81.3 + Nitisinone POS":"10713","Hgd82.1 + Nitisinone POS":"8087","Hgd82.2 + Nitisinone POS":"9739","Hgd83.1 + Nitisinone POS":"9490","Hgd83.2 - No treatment POS":"10827","Hgd80.3 - No treatment POS":"9349","Hgd80.4 - No treatment POS":"13469","Hgd81.4 - No treatment POS":"8916","Hgd81.5 - No treatment POS":"8667","Hgd81.6 - No treatment POS":"10083","Hgd82.3 - No treatment POS":"8751","Hgd82.4 - No treatment POS":"10767","Hgd83.3 - No treatment POS":"11222","Hgd83.4 - No treatment POS":"12363"},{"Metabolite":"Dulcitol","Hgd80.2 + Nitisinone POS":"99543","Hgd81.1 + Nitisinone POS":"121818","Hgd81.2 + Nitisinone POS":"241108","Hgd81.3 + Nitisinone POS":"193481","Hgd82.1 + Nitisinone POS":"64188","Hgd82.2 + Nitisinone POS":"127342","Hgd83.1 + Nitisinone POS":"75775","Hgd83.2 - No treatment POS":"46056","Hgd80.3 - No treatment POS":"92218","Hgd80.4 - No treatment POS":"70610","Hgd81.4 - No treatment POS":"87297","Hgd81.5 - No treatment POS":"594385","Hgd81.6 - No treatment POS":"59929","Hgd82.3 - No treatment POS":"325844","Hgd82.4 - No treatment POS":"143663","Hgd83.3 - No treatment POS":"68748","Hgd83.4 - No treatment POS":"246722"},{"Metabolite":"myo-Inositol","Hgd80.2 + Nitisinone POS":"950049","Hgd81.1 + Nitisinone POS":"188581","Hgd81.2 + Nitisinone POS":"169483","Hgd81.3 + Nitisinone POS":"405522","Hgd82.1 + Nitisinone POS":"169087","Hgd82.2 + Nitisinone POS":"111661","Hgd83.1 + Nitisinone POS":"134825","Hgd83.2 - No treatment POS":"212506","Hgd80.3 - No treatment POS":"1003364","Hgd80.4 - No treatment POS":"485925","Hgd81.4 - No treatment POS":"245433","Hgd81.5 - No treatment POS":"450223","Hgd81.6 - No treatment POS":"706585","Hgd82.3 - No treatment POS":"356792","Hgd82.4 - No treatment POS":"748828","Hgd83.3 - No treatment POS":"250961","Hgd83.4 - No treatment POS":"1132243"},{"Metabolite":"Hypoxanthine","Hgd80.2 + Nitisinone POS":"2867512","Hgd81.1 + Nitisinone POS":"1.09E+07","Hgd81.2 + Nitisinone POS":"8283657","Hgd81.3 + Nitisinone POS":"1.01E+07","Hgd82.1 + Nitisinone POS":"1.16E+07","Hgd82.2 + Nitisinone POS":"1.10E+07","Hgd83.1 + Nitisinone POS":"1.06E+07","Hgd83.2 - No treatment POS":"1.07E+07","Hgd80.3 - No treatment POS":"1.20E+07","Hgd80.4 - No treatment POS":"3124488","Hgd81.4 - No treatment POS":"1.14E+07","Hgd81.5 - No treatment POS":"3584142","Hgd81.6 - No treatment POS":"1.16E+07","Hgd82.3 - No treatment POS":"1.10E+07","Hgd82.4 - No treatment POS":"1.31E+07","Hgd83.3 - No treatment POS":"1.21E+07","Hgd83.4 - No treatment POS":"395998"},{"Metabolite":"Phosphocreatine","Hgd80.2 + Nitisinone POS":"119741","Hgd81.1 + Nitisinone POS":"94986","Hgd81.2 + Nitisinone POS":"105833","Hgd81.3 + Nitisinone POS":"105489","Hgd82.1 + Nitisinone POS":"94482","Hgd82.2 + Nitisinone POS":"102559","Hgd83.1 + Nitisinone POS":"92077","Hgd83.2 - No treatment POS":"102162","Hgd80.3 - No treatment POS":"138748","Hgd80.4 - No treatment POS":"134942","Hgd81.4 - No treatment POS":"118316","Hgd81.5 - No treatment POS":"112004","Hgd81.6 - No treatment POS":"92737","Hgd82.3 - No treatment POS":"87285","Hgd82.4 - No treatment POS":"101397","Hgd83.3 - No treatment POS":"102959","Hgd83.4 - No treatment POS":"136210"},{"Metabolite":"Thymidine","Hgd80.2 + Nitisinone POS":"69676","Hgd81.1 + Nitisinone POS":"82300","Hgd81.2 + Nitisinone POS":"48232","Hgd81.3 + Nitisinone POS":"61958","Hgd82.1 + Nitisinone POS":"96034","Hgd82.2 + Nitisinone POS":"77261","Hgd83.1 + Nitisinone POS":"93238","Hgd83.2 - No treatment POS":"90870","Hgd80.3 - No treatment POS":"65673","Hgd80.4 - No treatment POS":"58931","Hgd81.4 - No treatment POS":"60172","Hgd81.5 - No treatment POS":"69530","Hgd81.6 - No treatment POS":"80214","Hgd82.3 - No treatment POS":"93119","Hgd82.4 - No treatment POS":"76923","Hgd83.3 - No treatment POS":"75956","Hgd83.4 - No treatment POS":"88750"},{"Metabolite":"1-methylhistidine","Hgd80.2 + Nitisinone POS":"15546","Hgd81.1 + Nitisinone POS":"16117","Hgd81.2 + Nitisinone POS":"19151","Hgd81.3 + Nitisinone POS":"11284","Hgd82.1 + Nitisinone POS":"47715","Hgd82.2 + Nitisinone POS":"34710","Hgd83.1 + Nitisinone POS":"19153","Hgd83.2 - No treatment POS":"12829","Hgd80.3 - No treatment POS":"10002","Hgd80.4 - No treatment POS":"21228","Hgd81.4 - No treatment POS":"29245","Hgd81.5 - No treatment POS":"22835","Hgd81.6 - No treatment POS":"22725","Hgd82.3 - No treatment POS":"40741","Hgd82.4 - No treatment POS":"47230","Hgd83.3 - No treatment POS":"22310","Hgd83.4 - No treatment POS":"18332"},{"Metabolite":"DL-pipecolic acid","Hgd80.2 + Nitisinone POS":"49302","Hgd81.1 + Nitisinone POS":"21913","Hgd81.2 + Nitisinone POS":"20112","Hgd81.3 + Nitisinone POS":"28058","Hgd82.1 + Nitisinone POS":"106503","Hgd82.2 + Nitisinone POS":"69115","Hgd83.1 + Nitisinone POS":"19102","Hgd83.2 - No treatment POS":"17758","Hgd80.3 - No treatment POS":"37929","Hgd80.4 - No treatment POS":"48680","Hgd81.4 - No treatment POS":"35146","Hgd81.5 - No treatment POS":"57439","Hgd81.6 - No treatment POS":"34751","Hgd82.3 - No treatment POS":"65513","Hgd82.4 - No treatment POS":"69077","Hgd83.3 - No treatment POS":"27951","Hgd83.4 - No treatment POS":"26177"},{"Metabolite":"4-acetamidobutanoate","Hgd80.2 + Nitisinone POS":"18573","Hgd81.1 + Nitisinone POS":"15623","Hgd81.2 + Nitisinone POS":"3067","Hgd81.3 + Nitisinone POS":"25754","Hgd82.1 + Nitisinone POS":"38081","Hgd82.2 + Nitisinone POS":"18542","Hgd83.1 + Nitisinone POS":"10690","Hgd83.2 - No treatment POS":"36670","Hgd80.3 - No treatment POS":"22654","Hgd80.4 - No treatment POS":"24477","Hgd81.4 - No treatment POS":"15873","Hgd81.5 - No treatment POS":"35583","Hgd81.6 - No treatment POS":"12747","Hgd82.3 - No treatment POS":"31201","Hgd82.4 - No treatment POS":"21486","Hgd83.3 - No treatment POS":"42080","Hgd83.4 - No treatment POS":"52261"},{"Metabolite":"Theophylline","Hgd80.2 + Nitisinone POS":"13836","Hgd81.1 + Nitisinone POS":"2179","Hgd81.2 + Nitisinone POS":"7743","Hgd81.3 + Nitisinone POS":"3704","Hgd82.1 + Nitisinone POS":"7269","Hgd82.2 + Nitisinone POS":"1037","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"1","Hgd80.3 - No treatment POS":"8371","Hgd80.4 - No treatment POS":"3191","Hgd81.4 - No treatment POS":"6104","Hgd81.5 - No treatment POS":"13140","Hgd81.6 - No treatment POS":"9370","Hgd82.3 - No treatment POS":"861","Hgd82.4 - No treatment POS":"7886","Hgd83.3 - No treatment POS":"5095","Hgd83.4 - No treatment POS":"4108"},{"Metabolite":"L-Tryptophan","Hgd80.2 + Nitisinone POS":"484165","Hgd81.1 + Nitisinone POS":"363105","Hgd81.2 + Nitisinone POS":"241291","Hgd81.3 + Nitisinone POS":"314349","Hgd82.1 + Nitisinone POS":"327042","Hgd82.2 + Nitisinone POS":"290644","Hgd83.1 + Nitisinone POS":"296658","Hgd83.2 - No treatment POS":"472479","Hgd80.3 - No treatment POS":"442315","Hgd80.4 - No treatment POS":"458497","Hgd81.4 - No treatment POS":"315894","Hgd81.5 - No treatment POS":"575480","Hgd81.6 - No treatment POS":"434960","Hgd82.3 - No treatment POS":"178406","Hgd82.4 - No treatment POS":"417303","Hgd83.3 - No treatment POS":"452340","Hgd83.4 - No treatment POS":"625359"},{"Metabolite":"Niacinamide","Hgd80.2 + Nitisinone POS":"3911972","Hgd81.1 + Nitisinone POS":"5049253","Hgd81.2 + Nitisinone POS":"2614194","Hgd81.3 + Nitisinone POS":"4285072","Hgd82.1 + Nitisinone POS":"1.00E+07","Hgd82.2 + Nitisinone POS":"6882845","Hgd83.1 + Nitisinone POS":"6205599","Hgd83.2 - No treatment POS":"5537467","Hgd80.3 - No treatment POS":"5262513","Hgd80.4 - No treatment POS":"5205195","Hgd81.4 - No treatment POS":"6050538","Hgd81.5 - No treatment POS":"6394836","Hgd81.6 - No treatment POS":"5054419","Hgd82.3 - No treatment POS":"6649651","Hgd82.4 - No treatment POS":"7078067","Hgd83.3 - No treatment POS":"6629124","Hgd83.4 - No treatment POS":"6037039"},{"Metabolite":"Cytidine","Hgd80.2 + Nitisinone POS":"4510614","Hgd81.1 + Nitisinone POS":"5107240","Hgd81.2 + Nitisinone POS":"3415030","Hgd81.3 + Nitisinone POS":"4057828","Hgd82.1 + Nitisinone POS":"3049089","Hgd82.2 + Nitisinone POS":"4130054","Hgd83.1 + Nitisinone POS":"5285237","Hgd83.2 - No treatment POS":"5161713","Hgd80.3 - No treatment POS":"4598287","Hgd80.4 - No treatment POS":"4140941","Hgd81.4 - No treatment POS":"4336203","Hgd81.5 - No treatment POS":"5031404","Hgd81.6 - No treatment POS":"4511121","Hgd82.3 - No treatment POS":"5112675","Hgd82.4 - No treatment POS":"5081954","Hgd83.3 - No treatment POS":"4822599","Hgd83.4 - No treatment POS":"4760439"},{"Metabolite":"L-Threonine","Hgd80.2 + Nitisinone POS":"124077","Hgd81.1 + Nitisinone POS":"106973","Hgd81.2 + Nitisinone POS":"197165","Hgd81.3 + Nitisinone POS":"105458","Hgd82.1 + Nitisinone POS":"66717","Hgd82.2 + Nitisinone POS":"75092","Hgd83.1 + Nitisinone POS":"121062","Hgd83.2 - No treatment POS":"121120","Hgd80.3 - No treatment POS":"110201","Hgd80.4 - No treatment POS":"112946","Hgd81.4 - No treatment POS":"112564","Hgd81.5 - No treatment POS":"123370","Hgd81.6 - No treatment POS":"92918","Hgd82.3 - No treatment POS":"101837","Hgd82.4 - No treatment POS":"89639","Hgd83.3 - No treatment POS":"195037","Hgd83.4 - No treatment POS":"171001"},{"Metabolite":"Malic acid","Hgd80.2 + Nitisinone POS":"13841","Hgd81.1 + Nitisinone POS":"11967","Hgd81.2 + Nitisinone POS":"20298","Hgd81.3 + Nitisinone POS":"17293","Hgd82.1 + Nitisinone POS":"36353","Hgd82.2 + Nitisinone POS":"23538","Hgd83.1 + Nitisinone POS":"13879","Hgd83.2 - No treatment POS":"20476","Hgd80.3 - No treatment POS":"9282","Hgd80.4 - No treatment POS":"11781","Hgd81.4 - No treatment POS":"22133","Hgd81.5 - No treatment POS":"15343","Hgd81.6 - No treatment POS":"28331","Hgd82.3 - No treatment POS":"12785","Hgd82.4 - No treatment POS":"21987","Hgd83.3 - No treatment POS":"18406","Hgd83.4 - No treatment POS":"18509"},{"Metabolite":"L-Isoleucine","Hgd80.2 + Nitisinone POS":"648897","Hgd81.1 + Nitisinone POS":"523715","Hgd81.2 + Nitisinone POS":"457972","Hgd81.3 + Nitisinone POS":"511396","Hgd82.1 + Nitisinone POS":"755224","Hgd82.2 + Nitisinone POS":"567192","Hgd83.1 + Nitisinone POS":"478361","Hgd83.2 - No treatment POS":"653580","Hgd80.3 - No treatment POS":"661404","Hgd80.4 - No treatment POS":"597771","Hgd81.4 - No treatment POS":"492557","Hgd81.5 - No treatment POS":"780631","Hgd81.6 - No treatment POS":"592363","Hgd82.3 - No treatment POS":"399523","Hgd82.4 - No treatment POS":"635290","Hgd83.3 - No treatment POS":"630352","Hgd83.4 - No treatment POS":"729273"},{"Metabolite":"N-Acetyl-L-glutamic acid","Hgd80.2 + Nitisinone POS":"24816","Hgd81.1 + Nitisinone POS":"26799","Hgd81.2 + Nitisinone POS":"21622","Hgd81.3 + Nitisinone POS":"30367","Hgd82.1 + Nitisinone POS":"30915","Hgd82.2 + Nitisinone POS":"39825","Hgd83.1 + Nitisinone POS":"36569","Hgd83.2 - No treatment POS":"47558","Hgd80.3 - No treatment POS":"41711","Hgd80.4 - No treatment POS":"57776","Hgd81.4 - No treatment POS":"48044","Hgd81.5 - No treatment POS":"51853","Hgd81.6 - No treatment POS":"63495","Hgd82.3 - No treatment POS":"38967","Hgd82.4 - No treatment POS":"70302","Hgd83.3 - No treatment POS":"55714","Hgd83.4 - No treatment POS":"61409"},{"Metabolite":"D-Mannitol","Hgd80.2 + Nitisinone POS":"99460","Hgd81.1 + Nitisinone POS":"121823","Hgd81.2 + Nitisinone POS":"241108","Hgd81.3 + Nitisinone POS":"193481","Hgd82.1 + Nitisinone POS":"64188","Hgd82.2 + Nitisinone POS":"127342","Hgd83.1 + Nitisinone POS":"75775","Hgd83.2 - No treatment POS":"46056","Hgd80.3 - No treatment POS":"92228","Hgd80.4 - No treatment POS":"70612","Hgd81.4 - No treatment POS":"87297","Hgd81.5 - No treatment POS":"594383","Hgd81.6 - No treatment POS":"59927","Hgd82.3 - No treatment POS":"325857","Hgd82.4 - No treatment POS":"143663","Hgd83.3 - No treatment POS":"68757","Hgd83.4 - No treatment POS":"246722"},{"Metabolite":"L-Aspartic Acid","Hgd80.2 + Nitisinone POS":"40690","Hgd81.1 + Nitisinone POS":"43064","Hgd81.2 + Nitisinone POS":"25709","Hgd81.3 + Nitisinone POS":"26831","Hgd82.1 + Nitisinone POS":"16201","Hgd82.2 + Nitisinone POS":"29121","Hgd83.1 + Nitisinone POS":"35989","Hgd83.2 - No treatment POS":"40697","Hgd80.3 - No treatment POS":"34298","Hgd80.4 - No treatment POS":"38093","Hgd81.4 - No treatment POS":"34426","Hgd81.5 - No treatment POS":"33318","Hgd81.6 - No treatment POS":"29628","Hgd82.3 - No treatment POS":"40139","Hgd82.4 - No treatment POS":"38218","Hgd83.3 - No treatment POS":"43074","Hgd83.4 - No treatment POS":"50055"},{"Metabolite":"Adenosine","Hgd80.2 + Nitisinone POS":"1073354","Hgd81.1 + Nitisinone POS":"1249020","Hgd81.2 + Nitisinone POS":"9662401","Hgd81.3 + Nitisinone POS":"215730","Hgd82.1 + Nitisinone POS":"823376","Hgd82.2 + Nitisinone POS":"896599","Hgd83.1 + Nitisinone POS":"1331946","Hgd83.2 - No treatment POS":"3244738","Hgd80.3 - No treatment POS":"372430","Hgd80.4 - No treatment POS":"284084","Hgd81.4 - No treatment POS":"2251129","Hgd81.5 - No treatment POS":"863852","Hgd81.6 - No treatment POS":"9513782","Hgd82.3 - No treatment POS":"68700","Hgd82.4 - No treatment POS":"228664","Hgd83.3 - No treatment POS":"589816","Hgd83.4 - No treatment POS":"601080"},{"Metabolite":"5-Hydroxyindoleacetic acid","Hgd80.2 + Nitisinone POS":"61991","Hgd81.1 + Nitisinone POS":"45620","Hgd81.2 + Nitisinone POS":"50676","Hgd81.3 + Nitisinone POS":"9979","Hgd82.1 + Nitisinone POS":"17919","Hgd82.2 + Nitisinone POS":"13941","Hgd83.1 + Nitisinone POS":"46445","Hgd83.2 - No treatment POS":"40196","Hgd80.3 - No treatment POS":"23893","Hgd80.4 - No treatment POS":"13574","Hgd81.4 - No treatment POS":"99686","Hgd81.5 - No treatment POS":"68144","Hgd81.6 - No treatment POS":"53576","Hgd82.3 - No treatment POS":"24128","Hgd82.4 - No treatment POS":"14469","Hgd83.3 - No treatment POS":"74878","Hgd83.4 - No treatment POS":"50863"},{"Metabolite":"Creatine","Hgd80.2 + Nitisinone POS":"4.38E+07","Hgd81.1 + Nitisinone POS":"4.14E+07","Hgd81.2 + Nitisinone POS":"3.34E+07","Hgd81.3 + Nitisinone POS":"4.01E+07","Hgd82.1 + Nitisinone POS":"7.17E+07","Hgd82.2 + Nitisinone POS":"4.89E+07","Hgd83.1 + Nitisinone POS":"4.22E+07","Hgd83.2 - No treatment POS":"4.78E+07","Hgd80.3 - No treatment POS":"4.01E+07","Hgd80.4 - No treatment POS":"4.13E+07","Hgd81.4 - No treatment POS":"3.84E+07","Hgd81.5 - No treatment POS":"4.80E+07","Hgd81.6 - No treatment POS":"5.13E+07","Hgd82.3 - No treatment POS":"4.10E+07","Hgd82.4 - No treatment POS":"4.79E+07","Hgd83.3 - No treatment POS":"4.72E+07","Hgd83.4 - No treatment POS":"4.41E+07"},{"Metabolite":"2-Aminoisobutyric acid","Hgd80.2 + Nitisinone POS":"9848","Hgd81.1 + Nitisinone POS":"7422","Hgd81.2 + Nitisinone POS":"19433","Hgd81.3 + Nitisinone POS":"49971","Hgd82.1 + Nitisinone POS":"31653","Hgd82.2 + Nitisinone POS":"70764","Hgd83.1 + Nitisinone POS":"21641","Hgd83.2 - No treatment POS":"18670","Hgd80.3 - No treatment POS":"19442","Hgd80.4 - No treatment POS":"43558","Hgd81.4 - No treatment POS":"17927","Hgd81.5 - No treatment POS":"25601","Hgd81.6 - No treatment POS":"28204","Hgd82.3 - No treatment POS":"13607","Hgd82.4 - No treatment POS":"48658","Hgd83.3 - No treatment POS":"29985","Hgd83.4 - No treatment POS":"26053"},{"Metabolite":"Acetyl-L-tyrosine","Hgd80.2 + Nitisinone POS":"38506","Hgd81.1 + Nitisinone POS":"34486","Hgd81.2 + Nitisinone POS":"17714","Hgd81.3 + Nitisinone POS":"20641","Hgd82.1 + Nitisinone POS":"35271","Hgd82.2 + Nitisinone POS":"18200","Hgd83.1 + Nitisinone POS":"31330","Hgd83.2 - No treatment POS":"39973","Hgd80.3 - No treatment POS":"2523","Hgd80.4 - No treatment POS":"2945","Hgd81.4 - No treatment POS":"1574","Hgd81.5 - No treatment POS":"3128","Hgd81.6 - No treatment POS":"1899","Hgd82.3 - No treatment POS":"2460","Hgd82.4 - No treatment POS":"2984","Hgd83.3 - No treatment POS":"3573","Hgd83.4 - No treatment POS":"5565"},{"Metabolite":"p-Hydroxyphenylacetic acid","Hgd80.2 + Nitisinone POS":"18927","Hgd81.1 + Nitisinone POS":"11060","Hgd81.2 + Nitisinone POS":"7490","Hgd81.3 + Nitisinone POS":"6964","Hgd82.1 + Nitisinone POS":"6206","Hgd82.2 + Nitisinone POS":"4491","Hgd83.1 + Nitisinone POS":"10471","Hgd83.2 - No treatment POS":"11819","Hgd80.3 - No treatment POS":"1","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"1","Hgd81.6 - No treatment POS":"1","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"1","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"1"},{"Metabolite":"Quinic acid","Hgd80.2 + Nitisinone POS":"11410","Hgd81.1 + Nitisinone POS":"7543","Hgd81.2 + Nitisinone POS":"7840","Hgd81.3 + Nitisinone POS":"16447","Hgd82.1 + Nitisinone POS":"1","Hgd82.2 + Nitisinone POS":"11881","Hgd83.1 + Nitisinone POS":"6471","Hgd83.2 - No treatment POS":"4771","Hgd80.3 - No treatment POS":"17581","Hgd80.4 - No treatment POS":"14877","Hgd81.4 - No treatment POS":"10319","Hgd81.5 - No treatment POS":"10315","Hgd81.6 - No treatment POS":"8672","Hgd82.3 - No treatment POS":"9775","Hgd82.4 - No treatment POS":"15567","Hgd83.3 - No treatment POS":"8524","Hgd83.4 - No treatment POS":"8843"},{"Metabolite":"Methyl N-(a-methylbutyryl)glycine","Hgd80.2 + Nitisinone POS":"129548","Hgd81.1 + Nitisinone POS":"70814","Hgd81.2 + Nitisinone POS":"70924","Hgd81.3 + Nitisinone POS":"803809","Hgd82.1 + Nitisinone POS":"175604","Hgd82.2 + Nitisinone POS":"102955","Hgd83.1 + Nitisinone POS":"194797","Hgd83.2 - No treatment POS":"1692926","Hgd80.3 - No treatment POS":"129280","Hgd80.4 - No treatment POS":"78299","Hgd81.4 - No treatment POS":"118890","Hgd81.5 - No treatment POS":"176404","Hgd81.6 - No treatment POS":"104682","Hgd82.3 - No treatment POS":"2091839","Hgd82.4 - No treatment POS":"374433","Hgd83.3 - No treatment POS":"153962","Hgd83.4 - No treatment POS":"160638"},{"Metabolite":"3-Methyladenine","Hgd80.2 + Nitisinone POS":"102093","Hgd81.1 + Nitisinone POS":"121406","Hgd81.2 + Nitisinone POS":"110355","Hgd81.3 + Nitisinone POS":"157003","Hgd82.1 + Nitisinone POS":"60323","Hgd82.2 + Nitisinone POS":"62652","Hgd83.1 + Nitisinone POS":"134773","Hgd83.2 - No treatment POS":"121790","Hgd80.3 - No treatment POS":"169751","Hgd80.4 - No treatment POS":"169866","Hgd81.4 - No treatment POS":"127049","Hgd81.5 - No treatment POS":"74568","Hgd81.6 - No treatment POS":"72724","Hgd82.3 - No treatment POS":"63920","Hgd82.4 - No treatment POS":"139495","Hgd83.3 - No treatment POS":"101634","Hgd83.4 - No treatment POS":"137192"},{"Metabolite":"Maleamic acid","Hgd80.2 + Nitisinone POS":"18247","Hgd81.1 + Nitisinone POS":"21090","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"13892","Hgd82.1 + Nitisinone POS":"1","Hgd82.2 + Nitisinone POS":"16745","Hgd83.1 + Nitisinone POS":"18257","Hgd83.2 - No treatment POS":"18253","Hgd80.3 - No treatment POS":"1","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"20126","Hgd81.6 - No treatment POS":"1","Hgd82.3 - No treatment POS":"14430","Hgd82.4 - No treatment POS":"16861","Hgd83.3 - No treatment POS":"19234","Hgd83.4 - No treatment POS":"37901"},{"Metabolite":"D-Aspartic acid","Hgd80.2 + Nitisinone POS":"33921","Hgd81.1 + Nitisinone POS":"34882","Hgd81.2 + Nitisinone POS":"23402","Hgd81.3 + Nitisinone POS":"23199","Hgd82.1 + Nitisinone POS":"13752","Hgd82.2 + Nitisinone POS":"25310","Hgd83.1 + Nitisinone POS":"29649","Hgd83.2 - No treatment POS":"33543","Hgd80.3 - No treatment POS":"29307","Hgd80.4 - No treatment POS":"33927","Hgd81.4 - No treatment POS":"30440","Hgd81.5 - No treatment POS":"27843","Hgd81.6 - No treatment POS":"25733","Hgd82.3 - No treatment POS":"34209","Hgd82.4 - No treatment POS":"32642","Hgd83.3 - No treatment POS":"36165","Hgd83.4 - No treatment POS":"37642"},{"Metabolite":"12-Hydroxydodecanoic acid","Hgd80.2 + Nitisinone POS":"19983","Hgd81.1 + Nitisinone POS":"6859","Hgd81.2 + Nitisinone POS":"19435","Hgd81.3 + Nitisinone POS":"17832","Hgd82.1 + Nitisinone POS":"3620","Hgd82.2 + Nitisinone POS":"5502","Hgd83.1 + Nitisinone POS":"13359","Hgd83.2 - No treatment POS":"61441","Hgd80.3 - No treatment POS":"3914","Hgd80.4 - No treatment POS":"2853","Hgd81.4 - No treatment POS":"9615","Hgd81.5 - No treatment POS":"6114","Hgd81.6 - No treatment POS":"5982","Hgd82.3 - No treatment POS":"21797","Hgd82.4 - No treatment POS":"4141","Hgd83.3 - No treatment POS":"8467","Hgd83.4 - No treatment POS":"8721"},{"Metabolite":"Histamine","Hgd80.2 + Nitisinone POS":"33320","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"1","Hgd82.1 + Nitisinone POS":"96482","Hgd82.2 + Nitisinone POS":"40222","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"1","Hgd80.3 - No treatment POS":"1","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"1","Hgd81.6 - No treatment POS":"40055","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"1","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"1"},{"Metabolite":"Pantothenic Acid","Hgd80.2 + Nitisinone POS":"4486677","Hgd81.1 + Nitisinone POS":"3397242","Hgd81.2 + Nitisinone POS":"2813678","Hgd81.3 + Nitisinone POS":"3240376","Hgd82.1 + Nitisinone POS":"2668242","Hgd82.2 + Nitisinone POS":"2405047","Hgd83.1 + Nitisinone POS":"4097222","Hgd83.2 - No treatment POS":"4442885","Hgd80.3 - No treatment POS":"4282374","Hgd80.4 - No treatment POS":"4426220","Hgd81.4 - No treatment POS":"4294624","Hgd81.5 - No treatment POS":"4787631","Hgd81.6 - No treatment POS":"3592439","Hgd82.3 - No treatment POS":"2411664","Hgd82.4 - No treatment POS":"2928244","Hgd83.3 - No treatment POS":"4986370","Hgd83.4 - No treatment POS":"5117808"},{"Metabolite":"3-Ureidopropionic acid","Hgd80.2 + Nitisinone POS":"56364","Hgd81.1 + Nitisinone POS":"46945","Hgd81.2 + Nitisinone POS":"37348","Hgd81.3 + Nitisinone POS":"61562","Hgd82.1 + Nitisinone POS":"21276","Hgd82.2 + Nitisinone POS":"27813","Hgd83.1 + Nitisinone POS":"63739","Hgd83.2 - No treatment POS":"42959","Hgd80.3 - No treatment POS":"139168","Hgd80.4 - No treatment POS":"65260","Hgd81.4 - No treatment POS":"82795","Hgd81.5 - No treatment POS":"54495","Hgd81.6 - No treatment POS":"43458","Hgd82.3 - No treatment POS":"51045","Hgd82.4 - No treatment POS":"34343","Hgd83.3 - No treatment POS":"54205","Hgd83.4 - No treatment POS":"99439"},{"Metabolite":"L-(-)-Arabitol","Hgd80.2 + Nitisinone POS":"209690","Hgd81.1 + Nitisinone POS":"194341","Hgd81.2 + Nitisinone POS":"182293","Hgd81.3 + Nitisinone POS":"173086","Hgd82.1 + Nitisinone POS":"43195","Hgd82.2 + Nitisinone POS":"88843","Hgd83.1 + Nitisinone POS":"211035","Hgd83.2 - No treatment POS":"155810","Hgd80.3 - No treatment POS":"274643","Hgd80.4 - No treatment POS":"201029","Hgd81.4 - No treatment POS":"245813","Hgd81.5 - No treatment POS":"152948","Hgd81.6 - No treatment POS":"143206","Hgd82.3 - No treatment POS":"152253","Hgd82.4 - No treatment POS":"143710","Hgd83.3 - No treatment POS":"188886","Hgd83.4 - No treatment POS":"225755"},{"Metabolite":"Glutamine","Hgd80.2 + Nitisinone POS":"9191101","Hgd81.1 + Nitisinone POS":"9583462","Hgd81.2 + Nitisinone POS":"4541594","Hgd81.3 + Nitisinone POS":"4359480","Hgd82.1 + Nitisinone POS":"4609960","Hgd82.2 + Nitisinone POS":"4776238","Hgd83.1 + Nitisinone POS":"7452358","Hgd83.2 - No treatment POS":"7229892","Hgd80.3 - No treatment POS":"7814806","Hgd80.4 - No treatment POS":"7257660","Hgd81.4 - No treatment POS":"6541876","Hgd81.5 - No treatment POS":"7207384","Hgd81.6 - No treatment POS":"6683188","Hgd82.3 - No treatment POS":"9410353","Hgd82.4 - No treatment POS":"6449269","Hgd83.3 - No treatment POS":"8370120","Hgd83.4 - No treatment POS":"6830842"},{"Metabolite":"2-Deoxy-D-Ribose","Hgd80.2 + Nitisinone POS":"96830","Hgd81.1 + Nitisinone POS":"71409","Hgd81.2 + Nitisinone POS":"80198","Hgd81.3 + Nitisinone POS":"99809","Hgd82.1 + Nitisinone POS":"53841","Hgd82.2 + Nitisinone POS":"98847","Hgd83.1 + Nitisinone POS":"158334","Hgd83.2 - No treatment POS":"83671","Hgd80.3 - No treatment POS":"97319","Hgd80.4 - No treatment POS":"64716","Hgd81.4 - No treatment POS":"45314","Hgd81.5 - No treatment POS":"54115","Hgd81.6 - No treatment POS":"86225","Hgd82.3 - No treatment POS":"49845","Hgd82.4 - No treatment POS":"63008","Hgd83.3 - No treatment POS":"70072","Hgd83.4 - No treatment POS":"103871"},{"Metabolite":"salsolinol","Hgd80.2 + Nitisinone POS":"15907","Hgd81.1 + Nitisinone POS":"23488","Hgd81.2 + Nitisinone POS":"8045","Hgd81.3 + Nitisinone POS":"37025","Hgd82.1 + Nitisinone POS":"58533","Hgd82.2 + Nitisinone POS":"51407","Hgd83.1 + Nitisinone POS":"8561","Hgd83.2 - No treatment POS":"6863","Hgd80.3 - No treatment POS":"134985","Hgd80.4 - No treatment POS":"144296","Hgd81.4 - No treatment POS":"17127","Hgd81.5 - No treatment POS":"51062","Hgd81.6 - No treatment POS":"2831","Hgd82.3 - No treatment POS":"33083","Hgd82.4 - No treatment POS":"76735","Hgd83.3 - No treatment POS":"12970","Hgd83.4 - No treatment POS":"13788"},{"Metabolite":"Creatinine","Hgd80.2 + Nitisinone POS":"1136294","Hgd81.1 + Nitisinone POS":"988610","Hgd81.2 + Nitisinone POS":"929513","Hgd81.3 + Nitisinone POS":"906217","Hgd82.1 + Nitisinone POS":"566178","Hgd82.2 + Nitisinone POS":"882648","Hgd83.1 + Nitisinone POS":"849493","Hgd83.2 - No treatment POS":"834809","Hgd80.3 - No treatment POS":"990463","Hgd80.4 - No treatment POS":"969407","Hgd81.4 - No treatment POS":"894700","Hgd81.5 - No treatment POS":"1036602","Hgd81.6 - No treatment POS":"890863","Hgd82.3 - No treatment POS":"895321","Hgd82.4 - No treatment POS":"702092","Hgd83.3 - No treatment POS":"926307","Hgd83.4 - No treatment POS":"913870"},{"Metabolite":"Cytosine","Hgd80.2 + Nitisinone POS":"2090936","Hgd81.1 + Nitisinone POS":"2340845","Hgd81.2 + Nitisinone POS":"1580444","Hgd81.3 + Nitisinone POS":"1843658","Hgd82.1 + Nitisinone POS":"1420428","Hgd82.2 + Nitisinone POS":"1911003","Hgd83.1 + Nitisinone POS":"2433749","Hgd83.2 - No treatment POS":"2400016","Hgd80.3 - No treatment POS":"2085904","Hgd80.4 - No treatment POS":"1867587","Hgd81.4 - No treatment POS":"1924390","Hgd81.5 - No treatment POS":"2296859","Hgd81.6 - No treatment POS":"2092098","Hgd82.3 - No treatment POS":"2439508","Hgd82.4 - No treatment POS":"2325851","Hgd83.3 - No treatment POS":"2197861","Hgd83.4 - No treatment POS":"2162801"},{"Metabolite":"Adenosine5'-monophosphate","Hgd80.2 + Nitisinone POS":"262503","Hgd81.1 + Nitisinone POS":"74535","Hgd81.2 + Nitisinone POS":"80684","Hgd81.3 + Nitisinone POS":"384935","Hgd82.1 + Nitisinone POS":"3375091","Hgd82.2 + Nitisinone POS":"513435","Hgd83.1 + Nitisinone POS":"103799","Hgd83.2 - No treatment POS":"90427","Hgd80.3 - No treatment POS":"340015","Hgd80.4 - No treatment POS":"887837","Hgd81.4 - No treatment POS":"492611","Hgd81.5 - No treatment POS":"292868","Hgd81.6 - No treatment POS":"165791","Hgd82.3 - No treatment POS":"206404","Hgd82.4 - No treatment POS":"1257455","Hgd83.3 - No treatment POS":"80601","Hgd83.4 - No treatment POS":"158902"},{"Metabolite":"D-Mannose 6-phosphate","Hgd80.2 + Nitisinone POS":"27883","Hgd81.1 + Nitisinone POS":"20768","Hgd81.2 + Nitisinone POS":"37869","Hgd81.3 + Nitisinone POS":"37592","Hgd82.1 + Nitisinone POS":"61973","Hgd82.2 + Nitisinone POS":"28845","Hgd83.1 + Nitisinone POS":"25591","Hgd83.2 - No treatment POS":"33211","Hgd80.3 - No treatment POS":"26223","Hgd80.4 - No treatment POS":"39443","Hgd81.4 - No treatment POS":"36361","Hgd81.5 - No treatment POS":"27718","Hgd81.6 - No treatment POS":"20945","Hgd82.3 - No treatment POS":"36053","Hgd82.4 - No treatment POS":"33442","Hgd83.3 - No treatment POS":"22877","Hgd83.4 - No treatment POS":"32939"},{"Metabolite":"a-N-Acetylglucosamine","Hgd80.2 + Nitisinone POS":"360434","Hgd81.1 + Nitisinone POS":"442099","Hgd81.2 + Nitisinone POS":"291868","Hgd81.3 + Nitisinone POS":"315003","Hgd82.1 + Nitisinone POS":"140830","Hgd82.2 + Nitisinone POS":"258389","Hgd83.1 + Nitisinone POS":"371571","Hgd83.2 - No treatment POS":"356361","Hgd80.3 - No treatment POS":"374164","Hgd80.4 - No treatment POS":"347179","Hgd81.4 - No treatment POS":"374016","Hgd81.5 - No treatment POS":"370484","Hgd81.6 - No treatment POS":"348628","Hgd82.3 - No treatment POS":"398491","Hgd82.4 - No treatment POS":"301852","Hgd83.3 - No treatment POS":"387635","Hgd83.4 - No treatment POS":"362560"},{"Metabolite":"L-Alanine","Hgd80.2 + Nitisinone POS":"186277","Hgd81.1 + Nitisinone POS":"171963","Hgd81.2 + Nitisinone POS":"149598","Hgd81.3 + Nitisinone POS":"169553","Hgd82.1 + Nitisinone POS":"263062","Hgd82.2 + Nitisinone POS":"189912","Hgd83.1 + Nitisinone POS":"176276","Hgd83.2 - No treatment POS":"197514","Hgd80.3 - No treatment POS":"171298","Hgd80.4 - No treatment POS":"171559","Hgd81.4 - No treatment POS":"156739","Hgd81.5 - No treatment POS":"186586","Hgd81.6 - No treatment POS":"208527","Hgd82.3 - No treatment POS":"170640","Hgd82.4 - No treatment POS":"187096","Hgd83.3 - No treatment POS":"195756","Hgd83.4 - No treatment POS":"182546"},{"Metabolite":"N-Acetyl-DL-serine","Hgd80.2 + Nitisinone POS":"106010","Hgd81.1 + Nitisinone POS":"121452","Hgd81.2 + Nitisinone POS":"110214","Hgd81.3 + Nitisinone POS":"108350","Hgd82.1 + Nitisinone POS":"77638","Hgd82.2 + Nitisinone POS":"98045","Hgd83.1 + Nitisinone POS":"141117","Hgd83.2 - No treatment POS":"115061","Hgd80.3 - No treatment POS":"106832","Hgd80.4 - No treatment POS":"95872","Hgd81.4 - No treatment POS":"128409","Hgd81.5 - No treatment POS":"97813","Hgd81.6 - No treatment POS":"107605","Hgd82.3 - No treatment POS":"140841","Hgd82.4 - No treatment POS":"94679","Hgd83.3 - No treatment POS":"99086","Hgd83.4 - No treatment POS":"118928"},{"Metabolite":"N-Formylmethionine","Hgd80.2 + Nitisinone POS":"5631","Hgd81.1 + Nitisinone POS":"8094","Hgd81.2 + Nitisinone POS":"4480","Hgd81.3 + Nitisinone POS":"5299","Hgd82.1 + Nitisinone POS":"10433","Hgd82.2 + Nitisinone POS":"6438","Hgd83.1 + Nitisinone POS":"6734","Hgd83.2 - No treatment POS":"7823","Hgd80.3 - No treatment POS":"8667","Hgd80.4 - No treatment POS":"9105","Hgd81.4 - No treatment POS":"8057","Hgd81.5 - No treatment POS":"8630","Hgd81.6 - No treatment POS":"6665","Hgd82.3 - No treatment POS":"7386","Hgd82.4 - No treatment POS":"7274","Hgd83.3 - No treatment POS":"7108","Hgd83.4 - No treatment POS":"9335"},{"Metabolite":"N-Acetyl-DL-methionine","Hgd80.2 + Nitisinone POS":"61991","Hgd81.1 + Nitisinone POS":"45620","Hgd81.2 + Nitisinone POS":"50676","Hgd81.3 + Nitisinone POS":"9979","Hgd82.1 + Nitisinone POS":"17919","Hgd82.2 + Nitisinone POS":"13941","Hgd83.1 + Nitisinone POS":"46445","Hgd83.2 - No treatment POS":"40196","Hgd80.3 - No treatment POS":"23893","Hgd80.4 - No treatment POS":"13574","Hgd81.4 - No treatment POS":"99686","Hgd81.5 - No treatment POS":"68144","Hgd81.6 - No treatment POS":"53576","Hgd82.3 - No treatment POS":"24128","Hgd82.4 - No treatment POS":"14469","Hgd83.3 - No treatment POS":"74878","Hgd83.4 - No treatment POS":"50863"},{"Metabolite":"Diacetyl","Hgd80.2 + Nitisinone POS":"58942","Hgd81.1 + Nitisinone POS":"47797","Hgd81.2 + Nitisinone POS":"62348","Hgd81.3 + Nitisinone POS":"48928","Hgd82.1 + Nitisinone POS":"45666","Hgd82.2 + Nitisinone POS":"36127","Hgd83.1 + Nitisinone POS":"53042","Hgd83.2 - No treatment POS":"50207","Hgd80.3 - No treatment POS":"43567","Hgd80.4 - No treatment POS":"48787","Hgd81.4 - No treatment POS":"48438","Hgd81.5 - No treatment POS":"49913","Hgd81.6 - No treatment POS":"63045","Hgd82.3 - No treatment POS":"59772","Hgd82.4 - No treatment POS":"37607","Hgd83.3 - No treatment POS":"51168","Hgd83.4 - No treatment POS":"42345"},{"Metabolite":"1-Methyladenosine","Hgd80.2 + Nitisinone POS":"7826","Hgd81.1 + Nitisinone POS":"9147","Hgd81.2 + Nitisinone POS":"5762","Hgd81.3 + Nitisinone POS":"3148","Hgd82.1 + Nitisinone POS":"6004","Hgd82.2 + Nitisinone POS":"5176","Hgd83.1 + Nitisinone POS":"6866","Hgd83.2 - No treatment POS":"7715","Hgd80.3 - No treatment POS":"4838","Hgd80.4 - No treatment POS":"4219","Hgd81.4 - No treatment POS":"6356","Hgd81.5 - No treatment POS":"7656","Hgd81.6 - No treatment POS":"9653","Hgd82.3 - No treatment POS":"8447","Hgd82.4 - No treatment POS":"2703","Hgd83.3 - No treatment POS":"7528","Hgd83.4 - No treatment POS":"6250"},{"Metabolite":"Xanthurenic acid","Hgd80.2 + Nitisinone POS":"3108","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"20488","Hgd82.1 + Nitisinone POS":"40958","Hgd82.2 + Nitisinone POS":"1","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"1","Hgd80.3 - No treatment POS":"63402","Hgd80.4 - No treatment POS":"100819","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"150","Hgd81.6 - No treatment POS":"7223","Hgd82.3 - No treatment POS":"9315","Hgd82.4 - No treatment POS":"59007","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"1"},{"Metabolite":"L-Anserine","Hgd80.2 + Nitisinone POS":"92778","Hgd81.1 + Nitisinone POS":"88412","Hgd81.2 + Nitisinone POS":"52555","Hgd81.3 + Nitisinone POS":"60096","Hgd82.1 + Nitisinone POS":"108108","Hgd82.2 + Nitisinone POS":"69322","Hgd83.1 + Nitisinone POS":"67889","Hgd83.2 - No treatment POS":"76022","Hgd80.3 - No treatment POS":"78176","Hgd80.4 - No treatment POS":"78745","Hgd81.4 - No treatment POS":"78115","Hgd81.5 - No treatment POS":"77995","Hgd81.6 - No treatment POS":"81264","Hgd82.3 - No treatment POS":"87667","Hgd82.4 - No treatment POS":"74114","Hgd83.3 - No treatment POS":"84593","Hgd83.4 - No treatment POS":"80558"},{"Metabolite":"D-Fructose 6-phosphate","Hgd80.2 + Nitisinone POS":"27883","Hgd81.1 + Nitisinone POS":"20768","Hgd81.2 + Nitisinone POS":"37869","Hgd81.3 + Nitisinone POS":"37592","Hgd82.1 + Nitisinone POS":"61973","Hgd82.2 + Nitisinone POS":"28845","Hgd83.1 + Nitisinone POS":"25591","Hgd83.2 - No treatment POS":"33211","Hgd80.3 - No treatment POS":"26223","Hgd80.4 - No treatment POS":"39443","Hgd81.4 - No treatment POS":"36361","Hgd81.5 - No treatment POS":"27718","Hgd81.6 - No treatment POS":"20945","Hgd82.3 - No treatment POS":"36053","Hgd82.4 - No treatment POS":"33442","Hgd83.3 - No treatment POS":"22877","Hgd83.4 - No treatment POS":"32939"},{"Metabolite":"Diethanolamine","Hgd80.2 + Nitisinone POS":"10937","Hgd81.1 + Nitisinone POS":"35086","Hgd81.2 + Nitisinone POS":"45274","Hgd81.3 + Nitisinone POS":"24161","Hgd82.1 + Nitisinone POS":"25767","Hgd82.2 + Nitisinone POS":"64724","Hgd83.1 + Nitisinone POS":"13791","Hgd83.2 - No treatment POS":"7754","Hgd80.3 - No treatment POS":"25172","Hgd80.4 - No treatment POS":"15625","Hgd81.4 - No treatment POS":"21538","Hgd81.5 - No treatment POS":"122989","Hgd81.6 - No treatment POS":"15579","Hgd82.3 - No treatment POS":"17153","Hgd82.4 - No treatment POS":"11163","Hgd83.3 - No treatment POS":"18703","Hgd83.4 - No treatment POS":"45891"},{"Metabolite":"Pimelic acid","Hgd80.2 + Nitisinone POS":"25341","Hgd81.1 + Nitisinone POS":"11678","Hgd81.2 + Nitisinone POS":"5166","Hgd81.3 + Nitisinone POS":"86281","Hgd82.1 + Nitisinone POS":"28711","Hgd82.2 + Nitisinone POS":"12932","Hgd83.1 + Nitisinone POS":"25262","Hgd83.2 - No treatment POS":"185237","Hgd80.3 - No treatment POS":"16399","Hgd80.4 - No treatment POS":"16464","Hgd81.4 - No treatment POS":"18423","Hgd81.5 - No treatment POS":"30127","Hgd81.6 - No treatment POS":"16288","Hgd82.3 - No treatment POS":"59591","Hgd82.4 - No treatment POS":"46389","Hgd83.3 - No treatment POS":"24314","Hgd83.4 - No treatment POS":"45471"},{"Metabolite":"Suberic acid","Hgd80.2 + Nitisinone POS":"69324","Hgd81.1 + Nitisinone POS":"33370","Hgd81.2 + Nitisinone POS":"24379","Hgd81.3 + Nitisinone POS":"283325","Hgd82.1 + Nitisinone POS":"68594","Hgd82.2 + Nitisinone POS":"39843","Hgd83.1 + Nitisinone POS":"74926","Hgd83.2 - No treatment POS":"580392","Hgd80.3 - No treatment POS":"59643","Hgd80.4 - No treatment POS":"48476","Hgd81.4 - No treatment POS":"52982","Hgd81.5 - No treatment POS":"81658","Hgd81.6 - No treatment POS":"51760","Hgd82.3 - No treatment POS":"186128","Hgd82.4 - No treatment POS":"120942","Hgd83.3 - No treatment POS":"77105","Hgd83.4 - No treatment POS":"94969"},{"Metabolite":"D-MANNOSAMINE","Hgd80.2 + Nitisinone POS":"418732","Hgd81.1 + Nitisinone POS":"379238","Hgd81.2 + Nitisinone POS":"192566","Hgd81.3 + Nitisinone POS":"199201","Hgd82.1 + Nitisinone POS":"301297","Hgd82.2 + Nitisinone POS":"764294","Hgd83.1 + Nitisinone POS":"310352","Hgd83.2 - No treatment POS":"312291","Hgd80.3 - No treatment POS":"337509","Hgd80.4 - No treatment POS":"414061","Hgd81.4 - No treatment POS":"424808","Hgd81.5 - No treatment POS":"294307","Hgd81.6 - No treatment POS":"302410","Hgd82.3 - No treatment POS":"544740","Hgd82.4 - No treatment POS":"303492","Hgd83.3 - No treatment POS":"304609","Hgd83.4 - No treatment POS":"825685"},{"Metabolite":"D-Ribose","Hgd80.2 + Nitisinone POS":"124562","Hgd81.1 + Nitisinone POS":"153992","Hgd81.2 + Nitisinone POS":"120675","Hgd81.3 + Nitisinone POS":"127395","Hgd82.1 + Nitisinone POS":"65086","Hgd82.2 + Nitisinone POS":"90135","Hgd83.1 + Nitisinone POS":"144368","Hgd83.2 - No treatment POS":"129393","Hgd80.3 - No treatment POS":"205460","Hgd80.4 - No treatment POS":"167131","Hgd81.4 - No treatment POS":"138531","Hgd81.5 - No treatment POS":"116688","Hgd81.6 - No treatment POS":"117816","Hgd82.3 - No treatment POS":"82894","Hgd82.4 - No treatment POS":"153443","Hgd83.3 - No treatment POS":"160433","Hgd83.4 - No treatment POS":"163217"},{"Metabolite":"Deoxycytidine","Hgd80.2 + Nitisinone POS":"72472","Hgd81.1 + Nitisinone POS":"99358","Hgd81.2 + Nitisinone POS":"50588","Hgd81.3 + Nitisinone POS":"65084","Hgd82.1 + Nitisinone POS":"60406","Hgd82.2 + Nitisinone POS":"77961","Hgd83.1 + Nitisinone POS":"96248","Hgd83.2 - No treatment POS":"97541","Hgd80.3 - No treatment POS":"80813","Hgd80.4 - No treatment POS":"69173","Hgd81.4 - No treatment POS":"83816","Hgd81.5 - No treatment POS":"87404","Hgd81.6 - No treatment POS":"80269","Hgd82.3 - No treatment POS":"145513","Hgd82.4 - No treatment POS":"97991","Hgd83.3 - No treatment POS":"105799","Hgd83.4 - No treatment POS":"96236"},{"Metabolite":"N-Methyl-D-aspartic acid","Hgd80.2 + Nitisinone POS":"3652","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"78716","Hgd82.1 + Nitisinone POS":"120038","Hgd82.2 + Nitisinone POS":"90951","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"14485","Hgd80.3 - No treatment POS":"1","Hgd80.4 - No treatment POS":"111442","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"13057","Hgd81.6 - No treatment POS":"54143","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"83124","Hgd83.3 - No treatment POS":"3447","Hgd83.4 - No treatment POS":"5516"},{"Metabolite":"?-D-Glucose 1-phosphate","Hgd80.2 + Nitisinone POS":"27883","Hgd81.1 + Nitisinone POS":"20768","Hgd81.2 + Nitisinone POS":"37869","Hgd81.3 + Nitisinone POS":"37592","Hgd82.1 + Nitisinone POS":"61973","Hgd82.2 + Nitisinone POS":"28845","Hgd83.1 + Nitisinone POS":"25591","Hgd83.2 - No treatment POS":"33211","Hgd80.3 - No treatment POS":"26223","Hgd80.4 - No treatment POS":"39443","Hgd81.4 - No treatment POS":"36361","Hgd81.5 - No treatment POS":"27718","Hgd81.6 - No treatment POS":"20945","Hgd82.3 - No treatment POS":"36053","Hgd82.4 - No treatment POS":"33442","Hgd83.3 - No treatment POS":"22877","Hgd83.4 - No treatment POS":"32939"},{"Metabolite":"S-(5-ADENOSYL)-L-METHIONINE","Hgd80.2 + Nitisinone POS":"5534","Hgd81.1 + Nitisinone POS":"5335","Hgd81.2 + Nitisinone POS":"4735","Hgd81.3 + Nitisinone POS":"5263","Hgd82.1 + Nitisinone POS":"9198","Hgd82.2 + Nitisinone POS":"5155","Hgd83.1 + Nitisinone POS":"4927","Hgd83.2 - No treatment POS":"5621","Hgd80.3 - No treatment POS":"4900","Hgd80.4 - No treatment POS":"7085","Hgd81.4 - No treatment POS":"2160","Hgd81.5 - No treatment POS":"5095","Hgd81.6 - No treatment POS":"5083","Hgd82.3 - No treatment POS":"5286","Hgd82.4 - No treatment POS":"5755","Hgd83.3 - No treatment POS":"5417","Hgd83.4 - No treatment POS":"6161"},{"Metabolite":"Xanthine","Hgd80.2 + Nitisinone POS":"202526","Hgd81.1 + Nitisinone POS":"217944","Hgd81.2 + Nitisinone POS":"136721","Hgd81.3 + Nitisinone POS":"217129","Hgd82.1 + Nitisinone POS":"254797","Hgd82.2 + Nitisinone POS":"230629","Hgd83.1 + Nitisinone POS":"200330","Hgd83.2 - No treatment POS":"230096","Hgd80.3 - No treatment POS":"210971","Hgd80.4 - No treatment POS":"214055","Hgd81.4 - No treatment POS":"189332","Hgd81.5 - No treatment POS":"242014","Hgd81.6 - No treatment POS":"212343","Hgd82.3 - No treatment POS":"173839","Hgd82.4 - No treatment POS":"277372","Hgd83.3 - No treatment POS":"219403","Hgd83.4 - No treatment POS":"213872"},{"Metabolite":"Glyceryl phosphate","Hgd80.2 + Nitisinone POS":"99089","Hgd81.1 + Nitisinone POS":"93451","Hgd81.2 + Nitisinone POS":"114184","Hgd81.3 + Nitisinone POS":"170614","Hgd82.1 + Nitisinone POS":"122422","Hgd82.2 + Nitisinone POS":"152552","Hgd83.1 + Nitisinone POS":"101401","Hgd83.2 - No treatment POS":"105599","Hgd80.3 - No treatment POS":"141639","Hgd80.4 - No treatment POS":"139771","Hgd81.4 - No treatment POS":"113967","Hgd81.5 - No treatment POS":"121356","Hgd81.6 - No treatment POS":"126457","Hgd82.3 - No treatment POS":"68517","Hgd82.4 - No treatment POS":"141176","Hgd83.3 - No treatment POS":"115957","Hgd83.4 - No treatment POS":"106775"},{"Metabolite":"L-Norleucine","Hgd80.2 + Nitisinone POS":"648897","Hgd81.1 + Nitisinone POS":"523654","Hgd81.2 + Nitisinone POS":"457726","Hgd81.3 + Nitisinone POS":"512158","Hgd82.1 + Nitisinone POS":"755224","Hgd82.2 + Nitisinone POS":"569499","Hgd83.1 + Nitisinone POS":"478361","Hgd83.2 - No treatment POS":"653580","Hgd80.3 - No treatment POS":"661404","Hgd80.4 - No treatment POS":"598548","Hgd81.4 - No treatment POS":"496412","Hgd81.5 - No treatment POS":"780658","Hgd81.6 - No treatment POS":"598324","Hgd82.3 - No treatment POS":"398440","Hgd82.4 - No treatment POS":"635290","Hgd83.3 - No treatment POS":"635441","Hgd83.4 - No treatment POS":"728542"},{"Metabolite":"L-Serine","Hgd80.2 + Nitisinone POS":"23944","Hgd81.1 + Nitisinone POS":"22999","Hgd81.2 + Nitisinone POS":"48429","Hgd81.3 + Nitisinone POS":"26925","Hgd82.1 + Nitisinone POS":"26215","Hgd82.2 + Nitisinone POS":"25360","Hgd83.1 + Nitisinone POS":"29292","Hgd83.2 - No treatment POS":"31457","Hgd80.3 - No treatment POS":"28177","Hgd80.4 - No treatment POS":"18045","Hgd81.4 - No treatment POS":"25143","Hgd81.5 - No treatment POS":"24844","Hgd81.6 - No treatment POS":"36674","Hgd82.3 - No treatment POS":"16747","Hgd82.4 - No treatment POS":"21955","Hgd83.3 - No treatment POS":"40606","Hgd83.4 - No treatment POS":"30192"},{"Metabolite":"Xanthosine","Hgd80.2 + Nitisinone POS":"12644","Hgd81.1 + Nitisinone POS":"16113","Hgd81.2 + Nitisinone POS":"11118","Hgd81.3 + Nitisinone POS":"18867","Hgd82.1 + Nitisinone POS":"31140","Hgd82.2 + Nitisinone POS":"22400","Hgd83.1 + Nitisinone POS":"16131","Hgd83.2 - No treatment POS":"26757","Hgd80.3 - No treatment POS":"18039","Hgd80.4 - No treatment POS":"17507","Hgd81.4 - No treatment POS":"13671","Hgd81.5 - No treatment POS":"27158","Hgd81.6 - No treatment POS":"19066","Hgd82.3 - No treatment POS":"15296","Hgd82.4 - No treatment POS":"29709","Hgd83.3 - No treatment POS":"19130","Hgd83.4 - No treatment POS":"20198"},{"Metabolite":"D-Ornithine","Hgd80.2 + Nitisinone POS":"27998","Hgd81.1 + Nitisinone POS":"14961","Hgd81.2 + Nitisinone POS":"16689","Hgd81.3 + Nitisinone POS":"9022","Hgd82.1 + Nitisinone POS":"14641","Hgd82.2 + Nitisinone POS":"9534","Hgd83.1 + Nitisinone POS":"9165","Hgd83.2 - No treatment POS":"12453","Hgd80.3 - No treatment POS":"17512","Hgd80.4 - No treatment POS":"12262","Hgd81.4 - No treatment POS":"10167","Hgd81.5 - No treatment POS":"16369","Hgd81.6 - No treatment POS":"15772","Hgd82.3 - No treatment POS":"10956","Hgd82.4 - No treatment POS":"13076","Hgd83.3 - No treatment POS":"22915","Hgd83.4 - No treatment POS":"16352"},{"Metabolite":"D-(+)-Xylose","Hgd80.2 + Nitisinone POS":"124071","Hgd81.1 + Nitisinone POS":"153992","Hgd81.2 + Nitisinone POS":"120714","Hgd81.3 + Nitisinone POS":"127395","Hgd82.1 + Nitisinone POS":"65086","Hgd82.2 + Nitisinone POS":"90135","Hgd83.1 + Nitisinone POS":"144368","Hgd83.2 - No treatment POS":"129393","Hgd80.3 - No treatment POS":"205460","Hgd80.4 - No treatment POS":"167131","Hgd81.4 - No treatment POS":"138531","Hgd81.5 - No treatment POS":"116688","Hgd81.6 - No treatment POS":"117816","Hgd82.3 - No treatment POS":"82946","Hgd82.4 - No treatment POS":"153443","Hgd83.3 - No treatment POS":"160433","Hgd83.4 - No treatment POS":"162398"},{"Metabolite":"Corticosterone","Hgd80.2 + Nitisinone POS":"19516","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"17138","Hgd81.3 + Nitisinone POS":"6597","Hgd82.1 + Nitisinone POS":"1","Hgd82.2 + Nitisinone POS":"7783","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"29747","Hgd80.3 - No treatment POS":"6612","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"3428","Hgd81.5 - No treatment POS":"13606","Hgd81.6 - No treatment POS":"3251","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"1","Hgd83.3 - No treatment POS":"14757","Hgd83.4 - No treatment POS":"8504"},{"Metabolite":"N-Acetyl-?-D-mannosamine","Hgd80.2 + Nitisinone POS":"360434","Hgd81.1 + Nitisinone POS":"442099","Hgd81.2 + Nitisinone POS":"291868","Hgd81.3 + Nitisinone POS":"315003","Hgd82.1 + Nitisinone POS":"140830","Hgd82.2 + Nitisinone POS":"258389","Hgd83.1 + Nitisinone POS":"371571","Hgd83.2 - No treatment POS":"356361","Hgd80.3 - No treatment POS":"374164","Hgd80.4 - No treatment POS":"347179","Hgd81.4 - No treatment POS":"374016","Hgd81.5 - No treatment POS":"370484","Hgd81.6 - No treatment POS":"348628","Hgd82.3 - No treatment POS":"398491","Hgd82.4 - No treatment POS":"301852","Hgd83.3 - No treatment POS":"387635","Hgd83.4 - No treatment POS":"362560"},{"Metabolite":"DL-Homoserine","Hgd80.2 + Nitisinone POS":"124077","Hgd81.1 + Nitisinone POS":"106973","Hgd81.2 + Nitisinone POS":"197165","Hgd81.3 + Nitisinone POS":"105458","Hgd82.1 + Nitisinone POS":"66717","Hgd82.2 + Nitisinone POS":"75092","Hgd83.1 + Nitisinone POS":"121062","Hgd83.2 - No treatment POS":"121120","Hgd80.3 - No treatment POS":"110201","Hgd80.4 - No treatment POS":"112946","Hgd81.4 - No treatment POS":"112564","Hgd81.5 - No treatment POS":"123370","Hgd81.6 - No treatment POS":"92918","Hgd82.3 - No treatment POS":"101837","Hgd82.4 - No treatment POS":"89639","Hgd83.3 - No treatment POS":"195037","Hgd83.4 - No treatment POS":"171001"},{"Metabolite":"D-(+)-Malic acid","Hgd80.2 + Nitisinone POS":"13841","Hgd81.1 + Nitisinone POS":"7961","Hgd81.2 + Nitisinone POS":"13442","Hgd81.3 + Nitisinone POS":"17886","Hgd82.1 + Nitisinone POS":"36727","Hgd82.2 + Nitisinone POS":"25043","Hgd83.1 + Nitisinone POS":"13879","Hgd83.2 - No treatment POS":"24917","Hgd80.3 - No treatment POS":"9355","Hgd80.4 - No treatment POS":"11781","Hgd81.4 - No treatment POS":"11285","Hgd81.5 - No treatment POS":"16400","Hgd81.6 - No treatment POS":"30880","Hgd82.3 - No treatment POS":"13277","Hgd82.4 - No treatment POS":"22027","Hgd83.3 - No treatment POS":"20153","Hgd83.4 - No treatment POS":"20823"},{"Metabolite":"4-Pyridoxic acid","Hgd80.2 + Nitisinone POS":"13519","Hgd81.1 + Nitisinone POS":"8247","Hgd81.2 + Nitisinone POS":"6364","Hgd81.3 + Nitisinone POS":"9684","Hgd82.1 + Nitisinone POS":"8692","Hgd82.2 + Nitisinone POS":"10181","Hgd83.1 + Nitisinone POS":"10568","Hgd83.2 - No treatment POS":"16328","Hgd80.3 - No treatment POS":"8779","Hgd80.4 - No treatment POS":"9367","Hgd81.4 - No treatment POS":"9053","Hgd81.5 - No treatment POS":"14013","Hgd81.6 - No treatment POS":"1","Hgd82.3 - No treatment POS":"4471","Hgd82.4 - No treatment POS":"9582","Hgd83.3 - No treatment POS":"14808","Hgd83.4 - No treatment POS":"11138"},{"Metabolite":"Dihydroxyphenylacetic acid","Hgd80.2 + Nitisinone POS":"133388","Hgd81.1 + Nitisinone POS":"75825","Hgd81.2 + Nitisinone POS":"53846","Hgd81.3 + Nitisinone POS":"322258","Hgd82.1 + Nitisinone POS":"139071","Hgd82.2 + Nitisinone POS":"81742","Hgd83.1 + Nitisinone POS":"134534","Hgd83.2 - No treatment POS":"589007","Hgd80.3 - No treatment POS":"106251","Hgd80.4 - No treatment POS":"87973","Hgd81.4 - No treatment POS":"116340","Hgd81.5 - No treatment POS":"138867","Hgd81.6 - No treatment POS":"86300","Hgd82.3 - No treatment POS":"226977","Hgd82.4 - No treatment POS":"222760","Hgd83.3 - No treatment POS":"119535","Hgd83.4 - No treatment POS":"202991"},{"Metabolite":"D-Glucosamine 6-phosphate","Hgd80.2 + Nitisinone POS":"74047","Hgd81.1 + Nitisinone POS":"95119","Hgd81.2 + Nitisinone POS":"48395","Hgd81.3 + Nitisinone POS":"54645","Hgd82.1 + Nitisinone POS":"35172","Hgd82.2 + Nitisinone POS":"49186","Hgd83.1 + Nitisinone POS":"70260","Hgd83.2 - No treatment POS":"71551","Hgd80.3 - No treatment POS":"69842","Hgd80.4 - No treatment POS":"64374","Hgd81.4 - No treatment POS":"64737","Hgd81.5 - No treatment POS":"74484","Hgd81.6 - No treatment POS":"85423","Hgd82.3 - No treatment POS":"90107","Hgd82.4 - No treatment POS":"56684","Hgd83.3 - No treatment POS":"79311","Hgd83.4 - No treatment POS":"67953"},{"Metabolite":"N-Methylhistamine","Hgd80.2 + Nitisinone POS":"4972","Hgd81.1 + Nitisinone POS":"13641","Hgd81.2 + Nitisinone POS":"14505","Hgd81.3 + Nitisinone POS":"20310","Hgd82.1 + Nitisinone POS":"13951","Hgd82.2 + Nitisinone POS":"20191","Hgd83.1 + Nitisinone POS":"12067","Hgd83.2 - No treatment POS":"18105","Hgd80.3 - No treatment POS":"11004","Hgd80.4 - No treatment POS":"10142","Hgd81.4 - No treatment POS":"18029","Hgd81.5 - No treatment POS":"15938","Hgd81.6 - No treatment POS":"21357","Hgd82.3 - No treatment POS":"3614","Hgd82.4 - No treatment POS":"72487","Hgd83.3 - No treatment POS":"13711","Hgd83.4 - No treatment POS":"17793"},{"Metabolite":"Ketoleucine","Hgd80.2 + Nitisinone POS":"18251","Hgd81.1 + Nitisinone POS":"11319","Hgd81.2 + Nitisinone POS":"11653","Hgd81.3 + Nitisinone POS":"14560","Hgd82.1 + Nitisinone POS":"36997","Hgd82.2 + Nitisinone POS":"33387","Hgd83.1 + Nitisinone POS":"12453","Hgd83.2 - No treatment POS":"21757","Hgd80.3 - No treatment POS":"26723","Hgd80.4 - No treatment POS":"12127","Hgd81.4 - No treatment POS":"14267","Hgd81.5 - No treatment POS":"8441","Hgd81.6 - No treatment POS":"20268","Hgd82.3 - No treatment POS":"21683","Hgd82.4 - No treatment POS":"19576","Hgd83.3 - No treatment POS":"16200","Hgd83.4 - No treatment POS":"25149"},{"Metabolite":"AHBA","Hgd80.2 + Nitisinone POS":"59162","Hgd81.1 + Nitisinone POS":"65257","Hgd81.2 + Nitisinone POS":"52769","Hgd81.3 + Nitisinone POS":"48652","Hgd82.1 + Nitisinone POS":"59456","Hgd82.2 + Nitisinone POS":"48262","Hgd83.1 + Nitisinone POS":"63940","Hgd83.2 - No treatment POS":"55720","Hgd80.3 - No treatment POS":"53240","Hgd80.4 - No treatment POS":"59727","Hgd81.4 - No treatment POS":"48355","Hgd81.5 - No treatment POS":"60197","Hgd81.6 - No treatment POS":"63497","Hgd82.3 - No treatment POS":"58266","Hgd82.4 - No treatment POS":"49755","Hgd83.3 - No treatment POS":"59854","Hgd83.4 - No treatment POS":"56817"},{"Metabolite":"L-Phenylalanine","Hgd80.2 + Nitisinone POS":"1459871","Hgd81.1 + Nitisinone POS":"1275819","Hgd81.2 + Nitisinone POS":"737686","Hgd81.3 + Nitisinone POS":"952560","Hgd82.1 + Nitisinone POS":"1530803","Hgd82.2 + Nitisinone POS":"1044089","Hgd83.1 + Nitisinone POS":"1188752","Hgd83.2 - No treatment POS":"1532597","Hgd80.3 - No treatment POS":"1397008","Hgd80.4 - No treatment POS":"1350516","Hgd81.4 - No treatment POS":"993322","Hgd81.5 - No treatment POS":"1696131","Hgd81.6 - No treatment POS":"1281485","Hgd82.3 - No treatment POS":"1006935","Hgd82.4 - No treatment POS":"1449457","Hgd83.3 - No treatment POS":"1402069","Hgd83.4 - No treatment POS":"1644901"},{"Metabolite":"3-hydroxy-3-methyl-Glutaric acid","Hgd80.2 + Nitisinone POS":"35052","Hgd81.1 + Nitisinone POS":"27115","Hgd81.2 + Nitisinone POS":"23092","Hgd81.3 + Nitisinone POS":"33466","Hgd82.1 + Nitisinone POS":"27977","Hgd82.2 + Nitisinone POS":"29898","Hgd83.1 + Nitisinone POS":"32057","Hgd83.2 - No treatment POS":"39967","Hgd80.3 - No treatment POS":"30836","Hgd80.4 - No treatment POS":"37427","Hgd81.4 - No treatment POS":"22783","Hgd81.5 - No treatment POS":"38306","Hgd81.6 - No treatment POS":"40219","Hgd82.3 - No treatment POS":"25824","Hgd82.4 - No treatment POS":"29072","Hgd83.3 - No treatment POS":"43206","Hgd83.4 - No treatment POS":"50802"},{"Metabolite":"L-Methionine","Hgd80.2 + Nitisinone POS":"1930000","Hgd81.1 + Nitisinone POS":"1458323","Hgd81.2 + Nitisinone POS":"1484296","Hgd81.3 + Nitisinone POS":"1548535","Hgd82.1 + Nitisinone POS":"1974145","Hgd82.2 + Nitisinone POS":"1904929","Hgd83.1 + Nitisinone POS":"1424697","Hgd83.2 - No treatment POS":"1848920","Hgd80.3 - No treatment POS":"1668596","Hgd80.4 - No treatment POS":"1796335","Hgd81.4 - No treatment POS":"1431958","Hgd81.5 - No treatment POS":"2234768","Hgd81.6 - No treatment POS":"2403323","Hgd82.3 - No treatment POS":"1561466","Hgd82.4 - No treatment POS":"1569687","Hgd83.3 - No treatment POS":"1566663","Hgd83.4 - No treatment POS":"1503206"},{"Metabolite":"N-Acetyl-D-galactosamine","Hgd80.2 + Nitisinone POS":"360434","Hgd81.1 + Nitisinone POS":"442099","Hgd81.2 + Nitisinone POS":"291868","Hgd81.3 + Nitisinone POS":"315003","Hgd82.1 + Nitisinone POS":"140830","Hgd82.2 + Nitisinone POS":"258389","Hgd83.1 + Nitisinone POS":"371571","Hgd83.2 - No treatment POS":"356361","Hgd80.3 - No treatment POS":"374164","Hgd80.4 - No treatment POS":"347179","Hgd81.4 - No treatment POS":"374016","Hgd81.5 - No treatment POS":"370484","Hgd81.6 - No treatment POS":"348628","Hgd82.3 - No treatment POS":"398491","Hgd82.4 - No treatment POS":"301852","Hgd83.3 - No treatment POS":"387635","Hgd83.4 - No treatment POS":"362560"},{"Metabolite":"N-Acetyl-L-alanine","Hgd80.2 + Nitisinone POS":"145999","Hgd81.1 + Nitisinone POS":"172313","Hgd81.2 + Nitisinone POS":"113381","Hgd81.3 + Nitisinone POS":"117602","Hgd82.1 + Nitisinone POS":"159316","Hgd82.2 + Nitisinone POS":"120155","Hgd83.1 + Nitisinone POS":"153151","Hgd83.2 - No treatment POS":"163606","Hgd80.3 - No treatment POS":"138405","Hgd80.4 - No treatment POS":"148652","Hgd81.4 - No treatment POS":"150809","Hgd81.5 - No treatment POS":"157931","Hgd81.6 - No treatment POS":"138908","Hgd82.3 - No treatment POS":"156697","Hgd82.4 - No treatment POS":"154410","Hgd83.3 - No treatment POS":"154707","Hgd83.4 - No treatment POS":"172679"},{"Metabolite":"3-Methoxy-4-hydroxyphenylethylene glycol","Hgd80.2 + Nitisinone POS":"25723","Hgd81.1 + Nitisinone POS":"29847","Hgd81.2 + Nitisinone POS":"28936","Hgd81.3 + Nitisinone POS":"21719","Hgd82.1 + Nitisinone POS":"16235","Hgd82.2 + Nitisinone POS":"20595","Hgd83.1 + Nitisinone POS":"22030","Hgd83.2 - No treatment POS":"21381","Hgd80.3 - No treatment POS":"17080","Hgd80.4 - No treatment POS":"23535","Hgd81.4 - No treatment POS":"26409","Hgd81.5 - No treatment POS":"19573","Hgd81.6 - No treatment POS":"24639","Hgd82.3 - No treatment POS":"22267","Hgd82.4 - No treatment POS":"18675","Hgd83.3 - No treatment POS":"19674","Hgd83.4 - No treatment POS":"19468"},{"Metabolite":"Ribitol","Hgd80.2 + Nitisinone POS":"209690","Hgd81.1 + Nitisinone POS":"194341","Hgd81.2 + Nitisinone POS":"182293","Hgd81.3 + Nitisinone POS":"173086","Hgd82.1 + Nitisinone POS":"43195","Hgd82.2 + Nitisinone POS":"88843","Hgd83.1 + Nitisinone POS":"211035","Hgd83.2 - No treatment POS":"155810","Hgd80.3 - No treatment POS":"274643","Hgd80.4 - No treatment POS":"201029","Hgd81.4 - No treatment POS":"245813","Hgd81.5 - No treatment POS":"152948","Hgd81.6 - No treatment POS":"143206","Hgd82.3 - No treatment POS":"152253","Hgd82.4 - No treatment POS":"143710","Hgd83.3 - No treatment POS":"188886","Hgd83.4 - No treatment POS":"225755"},{"Metabolite":"?-Aminobutryic acid","Hgd80.2 + Nitisinone POS":"6317","Hgd81.1 + Nitisinone POS":"7422","Hgd81.2 + Nitisinone POS":"19430","Hgd81.3 + Nitisinone POS":"49968","Hgd82.1 + Nitisinone POS":"31653","Hgd82.2 + Nitisinone POS":"70680","Hgd83.1 + Nitisinone POS":"21669","Hgd83.2 - No treatment POS":"18670","Hgd80.3 - No treatment POS":"19582","Hgd80.4 - No treatment POS":"43558","Hgd81.4 - No treatment POS":"17843","Hgd81.5 - No treatment POS":"25601","Hgd81.6 - No treatment POS":"27997","Hgd82.3 - No treatment POS":"13607","Hgd82.4 - No treatment POS":"48739","Hgd83.3 - No treatment POS":"29985","Hgd83.4 - No treatment POS":"25493"},{"Metabolite":"Cortexolone","Hgd80.2 + Nitisinone POS":"19558","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"17344","Hgd81.3 + Nitisinone POS":"6586","Hgd82.1 + Nitisinone POS":"1","Hgd82.2 + Nitisinone POS":"7739","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"29760","Hgd80.3 - No treatment POS":"7597","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"3428","Hgd81.5 - No treatment POS":"13522","Hgd81.6 - No treatment POS":"3203","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"1","Hgd83.3 - No treatment POS":"14735","Hgd83.4 - No treatment POS":"8448"},{"Metabolite":"Spermidine","Hgd80.2 + Nitisinone POS":"297786","Hgd81.1 + Nitisinone POS":"220242","Hgd81.2 + Nitisinone POS":"104279","Hgd81.3 + Nitisinone POS":"473988","Hgd82.1 + Nitisinone POS":"1853405","Hgd82.2 + Nitisinone POS":"819257","Hgd83.1 + Nitisinone POS":"234826","Hgd83.2 - No treatment POS":"253074","Hgd80.3 - No treatment POS":"815999","Hgd80.4 - No treatment POS":"1198652","Hgd81.4 - No treatment POS":"570641","Hgd81.5 - No treatment POS":"691812","Hgd81.6 - No treatment POS":"663008","Hgd82.3 - No treatment POS":"525840","Hgd82.4 - No treatment POS":"1237556","Hgd83.3 - No treatment POS":"163881","Hgd83.4 - No treatment POS":"325102"},{"Metabolite":"R-(-)-Mandelic acid","Hgd80.2 + Nitisinone POS":"12704","Hgd81.1 + Nitisinone POS":"6881","Hgd81.2 + Nitisinone POS":"21114","Hgd81.3 + Nitisinone POS":"23842","Hgd82.1 + Nitisinone POS":"25815","Hgd82.2 + Nitisinone POS":"11298","Hgd83.1 + Nitisinone POS":"42351","Hgd83.2 - No treatment POS":"23880","Hgd80.3 - No treatment POS":"19897","Hgd80.4 - No treatment POS":"17387","Hgd81.4 - No treatment POS":"22326","Hgd81.5 - No treatment POS":"9224","Hgd81.6 - No treatment POS":"9356","Hgd82.3 - No treatment POS":"12424","Hgd82.4 - No treatment POS":"27767","Hgd83.3 - No treatment POS":"11103","Hgd83.4 - No treatment POS":"26204"},{"Metabolite":"4-Hydroxy-L-phenylglycine","Hgd80.2 + Nitisinone POS":"19734","Hgd81.1 + Nitisinone POS":"15952","Hgd81.2 + Nitisinone POS":"21026","Hgd81.3 + Nitisinone POS":"24975","Hgd82.1 + Nitisinone POS":"2338","Hgd82.2 + Nitisinone POS":"21962","Hgd83.1 + Nitisinone POS":"23519","Hgd83.2 - No treatment POS":"24675","Hgd80.3 - No treatment POS":"25212","Hgd80.4 - No treatment POS":"13544","Hgd81.4 - No treatment POS":"25446","Hgd81.5 - No treatment POS":"24689","Hgd81.6 - No treatment POS":"20433","Hgd82.3 - No treatment POS":"35997","Hgd82.4 - No treatment POS":"23621","Hgd83.3 - No treatment POS":"19788","Hgd83.4 - No treatment POS":"23485"},{"Metabolite":"Inosine 5'-monophosphate (IMP)","Hgd80.2 + Nitisinone POS":"5374","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"9396","Hgd82.1 + Nitisinone POS":"588420","Hgd82.2 + Nitisinone POS":"15836","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"1","Hgd80.3 - No treatment POS":"7198","Hgd80.4 - No treatment POS":"7113","Hgd81.4 - No treatment POS":"6456","Hgd81.5 - No treatment POS":"7222","Hgd81.6 - No treatment POS":"18711","Hgd82.3 - No treatment POS":"16682","Hgd82.4 - No treatment POS":"34414","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"1"},{"Metabolite":"Pyridoxamine","Hgd80.2 + Nitisinone POS":"341228","Hgd81.1 + Nitisinone POS":"381887","Hgd81.2 + Nitisinone POS":"355368","Hgd81.3 + Nitisinone POS":"398975","Hgd82.1 + Nitisinone POS":"396262","Hgd82.2 + Nitisinone POS":"373127","Hgd83.1 + Nitisinone POS":"428085","Hgd83.2 - No treatment POS":"450476","Hgd80.3 - No treatment POS":"422605","Hgd80.4 - No treatment POS":"358672","Hgd81.4 - No treatment POS":"415862","Hgd81.5 - No treatment POS":"420577","Hgd81.6 - No treatment POS":"385567","Hgd82.3 - No treatment POS":"302481","Hgd82.4 - No treatment POS":"324379","Hgd83.3 - No treatment POS":"501424","Hgd83.4 - No treatment POS":"1"},{"Metabolite":"Taurine","Hgd80.2 + Nitisinone POS":"164893","Hgd81.1 + Nitisinone POS":"160782","Hgd81.2 + Nitisinone POS":"210653","Hgd81.3 + Nitisinone POS":"312008","Hgd82.1 + Nitisinone POS":"1459491","Hgd82.2 + Nitisinone POS":"590531","Hgd83.1 + Nitisinone POS":"217879","Hgd83.2 - No treatment POS":"298694","Hgd80.3 - No treatment POS":"171914","Hgd80.4 - No treatment POS":"199491","Hgd81.4 - No treatment POS":"215705","Hgd81.5 - No treatment POS":"264472","Hgd81.6 - No treatment POS":"347092","Hgd82.3 - No treatment POS":"137394","Hgd82.4 - No treatment POS":"367011","Hgd83.3 - No treatment POS":"256747","Hgd83.4 - No treatment POS":"191605"},{"Metabolite":"N?,N?,N?-Trimethyllysine","Hgd80.2 + Nitisinone POS":"27959","Hgd81.1 + Nitisinone POS":"27464","Hgd81.2 + Nitisinone POS":"29481","Hgd81.3 + Nitisinone POS":"35007","Hgd82.1 + Nitisinone POS":"27948","Hgd82.2 + Nitisinone POS":"28838","Hgd83.1 + Nitisinone POS":"27426","Hgd83.2 - No treatment POS":"26282","Hgd80.3 - No treatment POS":"33538","Hgd80.4 - No treatment POS":"36084","Hgd81.4 - No treatment POS":"33627","Hgd81.5 - No treatment POS":"29657","Hgd81.6 - No treatment POS":"27522","Hgd82.3 - No treatment POS":"26538","Hgd82.4 - No treatment POS":"45535","Hgd83.3 - No treatment POS":"27154","Hgd83.4 - No treatment POS":"28558"},{"Metabolite":"L-Ornithine","Hgd80.2 + Nitisinone POS":"27998","Hgd81.1 + Nitisinone POS":"14961","Hgd81.2 + Nitisinone POS":"16689","Hgd81.3 + Nitisinone POS":"9022","Hgd82.1 + Nitisinone POS":"14641","Hgd82.2 + Nitisinone POS":"9534","Hgd83.1 + Nitisinone POS":"9165","Hgd83.2 - No treatment POS":"12453","Hgd80.3 - No treatment POS":"17512","Hgd80.4 - No treatment POS":"12262","Hgd81.4 - No treatment POS":"10167","Hgd81.5 - No treatment POS":"16369","Hgd81.6 - No treatment POS":"15772","Hgd82.3 - No treatment POS":"10956","Hgd82.4 - No treatment POS":"13102","Hgd83.3 - No treatment POS":"22915","Hgd83.4 - No treatment POS":"16352"},{"Metabolite":"L-Asparagine","Hgd80.2 + Nitisinone POS":"9847","Hgd81.1 + Nitisinone POS":"8104","Hgd81.2 + Nitisinone POS":"10477","Hgd81.3 + Nitisinone POS":"13717","Hgd82.1 + Nitisinone POS":"11311","Hgd82.2 + Nitisinone POS":"13744","Hgd83.1 + Nitisinone POS":"9944","Hgd83.2 - No treatment POS":"12456","Hgd80.3 - No treatment POS":"2281","Hgd80.4 - No treatment POS":"10503","Hgd81.4 - No treatment POS":"7832","Hgd81.5 - No treatment POS":"10693","Hgd81.6 - No treatment POS":"10346","Hgd82.3 - No treatment POS":"3048","Hgd82.4 - No treatment POS":"10756","Hgd83.3 - No treatment POS":"12408","Hgd83.4 - No treatment POS":"11358"},{"Metabolite":"Urocanic acid","Hgd80.2 + Nitisinone POS":"2589305","Hgd81.1 + Nitisinone POS":"1048339","Hgd81.2 + Nitisinone POS":"1526418","Hgd81.3 + Nitisinone POS":"405762","Hgd82.1 + Nitisinone POS":"1204334","Hgd82.2 + Nitisinone POS":"339045","Hgd83.1 + Nitisinone POS":"66451","Hgd83.2 - No treatment POS":"468377","Hgd80.3 - No treatment POS":"1481460","Hgd80.4 - No treatment POS":"672216","Hgd81.4 - No treatment POS":"1037673","Hgd81.5 - No treatment POS":"1489301","Hgd81.6 - No treatment POS":"1467676","Hgd82.3 - No treatment POS":"406775","Hgd82.4 - No treatment POS":"961315","Hgd83.3 - No treatment POS":"2587575","Hgd83.4 - No treatment POS":"1830999"},{"Metabolite":"D-Glucose 6-phosphate","Hgd80.2 + Nitisinone POS":"27883","Hgd81.1 + Nitisinone POS":"20768","Hgd81.2 + Nitisinone POS":"37869","Hgd81.3 + Nitisinone POS":"37592","Hgd82.1 + Nitisinone POS":"61973","Hgd82.2 + Nitisinone POS":"28845","Hgd83.1 + Nitisinone POS":"25591","Hgd83.2 - No treatment POS":"33211","Hgd80.3 - No treatment POS":"26223","Hgd80.4 - No treatment POS":"39443","Hgd81.4 - No treatment POS":"36361","Hgd81.5 - No treatment POS":"27718","Hgd81.6 - No treatment POS":"20945","Hgd82.3 - No treatment POS":"36053","Hgd82.4 - No treatment POS":"33442","Hgd83.3 - No treatment POS":"22877","Hgd83.4 - No treatment POS":"32939"},{"Metabolite":"L-(-)Sorbose","Hgd80.2 + Nitisinone POS":"950049","Hgd81.1 + Nitisinone POS":"188581","Hgd81.2 + Nitisinone POS":"169483","Hgd81.3 + Nitisinone POS":"405522","Hgd82.1 + Nitisinone POS":"179934","Hgd82.2 + Nitisinone POS":"124673","Hgd83.1 + Nitisinone POS":"134825","Hgd83.2 - No treatment POS":"212506","Hgd80.3 - No treatment POS":"1003364","Hgd80.4 - No treatment POS":"485925","Hgd81.4 - No treatment POS":"245433","Hgd81.5 - No treatment POS":"450223","Hgd81.6 - No treatment POS":"706585","Hgd82.3 - No treatment POS":"1868784","Hgd82.4 - No treatment POS":"748828","Hgd83.3 - No treatment POS":"250601","Hgd83.4 - No treatment POS":"1132243"},{"Metabolite":"3-Amino-4-hydroxybenzoic acid","Hgd80.2 + Nitisinone POS":"59162","Hgd81.1 + Nitisinone POS":"65257","Hgd81.2 + Nitisinone POS":"52769","Hgd81.3 + Nitisinone POS":"48652","Hgd82.1 + Nitisinone POS":"59456","Hgd82.2 + Nitisinone POS":"48262","Hgd83.1 + Nitisinone POS":"63940","Hgd83.2 - No treatment POS":"55720","Hgd80.3 - No treatment POS":"53240","Hgd80.4 - No treatment POS":"59727","Hgd81.4 - No treatment POS":"48355","Hgd81.5 - No treatment POS":"60197","Hgd81.6 - No treatment POS":"63497","Hgd82.3 - No treatment POS":"58266","Hgd82.4 - No treatment POS":"49755","Hgd83.3 - No treatment POS":"59854","Hgd83.4 - No treatment POS":"56817"},{"Metabolite":"Guanine","Hgd80.2 + Nitisinone POS":"79136","Hgd81.1 + Nitisinone POS":"87519","Hgd81.2 + Nitisinone POS":"795332","Hgd81.3 + Nitisinone POS":"76397","Hgd82.1 + Nitisinone POS":"77938","Hgd82.2 + Nitisinone POS":"98133","Hgd83.1 + Nitisinone POS":"140575","Hgd83.2 - No treatment POS":"569368","Hgd80.3 - No treatment POS":"78222","Hgd80.4 - No treatment POS":"74653","Hgd81.4 - No treatment POS":"109781","Hgd81.5 - No treatment POS":"138459","Hgd81.6 - No treatment POS":"103683","Hgd82.3 - No treatment POS":"69264","Hgd82.4 - No treatment POS":"68424","Hgd83.3 - No treatment POS":"494307","Hgd83.4 - No treatment POS":"95212"},{"Metabolite":"L-Lysine","Hgd80.2 + Nitisinone POS":"204031","Hgd81.1 + Nitisinone POS":"224923","Hgd81.2 + Nitisinone POS":"212428","Hgd81.3 + Nitisinone POS":"231501","Hgd82.1 + Nitisinone POS":"218049","Hgd82.2 + Nitisinone POS":"207200","Hgd83.1 + Nitisinone POS":"239437","Hgd83.2 - No treatment POS":"246269","Hgd80.3 - No treatment POS":"229437","Hgd80.4 - No treatment POS":"201940","Hgd81.4 - No treatment POS":"241037","Hgd81.5 - No treatment POS":"220877","Hgd81.6 - No treatment POS":"225797","Hgd82.3 - No treatment POS":"177986","Hgd82.4 - No treatment POS":"169687","Hgd83.3 - No treatment POS":"282753","Hgd83.4 - No treatment POS":"298398"},{"Metabolite":"Allothreonine","Hgd80.2 + Nitisinone POS":"124077","Hgd81.1 + Nitisinone POS":"106964","Hgd81.2 + Nitisinone POS":"197165","Hgd81.3 + Nitisinone POS":"105458","Hgd82.1 + Nitisinone POS":"66717","Hgd82.2 + Nitisinone POS":"75092","Hgd83.1 + Nitisinone POS":"121062","Hgd83.2 - No treatment POS":"121120","Hgd80.3 - No treatment POS":"110201","Hgd80.4 - No treatment POS":"112946","Hgd81.4 - No treatment POS":"112564","Hgd81.5 - No treatment POS":"123370","Hgd81.6 - No treatment POS":"92918","Hgd82.3 - No treatment POS":"101837","Hgd82.4 - No treatment POS":"89639","Hgd83.3 - No treatment POS":"195037","Hgd83.4 - No treatment POS":"171001"},{"Metabolite":"Citrulline","Hgd80.2 + Nitisinone POS":"127289","Hgd81.1 + Nitisinone POS":"122464","Hgd81.2 + Nitisinone POS":"69096","Hgd81.3 + Nitisinone POS":"44672","Hgd82.1 + Nitisinone POS":"49108","Hgd82.2 + Nitisinone POS":"35276","Hgd83.1 + Nitisinone POS":"88040","Hgd83.2 - No treatment POS":"90149","Hgd80.3 - No treatment POS":"111857","Hgd80.4 - No treatment POS":"92458","Hgd81.4 - No treatment POS":"90098","Hgd81.5 - No treatment POS":"104314","Hgd81.6 - No treatment POS":"102615","Hgd82.3 - No treatment POS":"115537","Hgd82.4 - No treatment POS":"65372","Hgd83.3 - No treatment POS":"112176","Hgd83.4 - No treatment POS":"272903"},{"Metabolite":"D-Tryptophan","Hgd80.2 + Nitisinone POS":"484165","Hgd81.1 + Nitisinone POS":"363105","Hgd81.2 + Nitisinone POS":"241291","Hgd81.3 + Nitisinone POS":"314349","Hgd82.1 + Nitisinone POS":"327042","Hgd82.2 + Nitisinone POS":"290644","Hgd83.1 + Nitisinone POS":"296658","Hgd83.2 - No treatment POS":"472464","Hgd80.3 - No treatment POS":"442315","Hgd80.4 - No treatment POS":"458497","Hgd81.4 - No treatment POS":"315894","Hgd81.5 - No treatment POS":"575480","Hgd81.6 - No treatment POS":"434960","Hgd82.3 - No treatment POS":"178406","Hgd82.4 - No treatment POS":"417303","Hgd83.3 - No treatment POS":"452340","Hgd83.4 - No treatment POS":"625393"},{"Metabolite":"D-Alanine","Hgd80.2 + Nitisinone POS":"178538","Hgd81.1 + Nitisinone POS":"163956","Hgd81.2 + Nitisinone POS":"141587","Hgd81.3 + Nitisinone POS":"160669","Hgd82.1 + Nitisinone POS":"254977","Hgd82.2 + Nitisinone POS":"180632","Hgd83.1 + Nitisinone POS":"167830","Hgd83.2 - No treatment POS":"189538","Hgd80.3 - No treatment POS":"163012","Hgd80.4 - No treatment POS":"162463","Hgd81.4 - No treatment POS":"148506","Hgd81.5 - No treatment POS":"178385","Hgd81.6 - No treatment POS":"200702","Hgd82.3 - No treatment POS":"163082","Hgd82.4 - No treatment POS":"179795","Hgd83.3 - No treatment POS":"186842","Hgd83.4 - No treatment POS":"174153"},{"Metabolite":"(-)-Epinephrine","Hgd80.2 + Nitisinone POS":"27232","Hgd81.1 + Nitisinone POS":"23671","Hgd81.2 + Nitisinone POS":"32336","Hgd81.3 + Nitisinone POS":"51600","Hgd82.1 + Nitisinone POS":"81158","Hgd82.2 + Nitisinone POS":"61850","Hgd83.1 + Nitisinone POS":"34275","Hgd83.2 - No treatment POS":"37750","Hgd80.3 - No treatment POS":"36012","Hgd80.4 - No treatment POS":"44985","Hgd81.4 - No treatment POS":"46892","Hgd81.5 - No treatment POS":"29703","Hgd81.6 - No treatment POS":"39013","Hgd82.3 - No treatment POS":"25349","Hgd82.4 - No treatment POS":"51395","Hgd83.3 - No treatment POS":"33313","Hgd83.4 - No treatment POS":"46004"},{"Metabolite":"O-Acetylserine","Hgd80.2 + Nitisinone POS":"118789","Hgd81.1 + Nitisinone POS":"133630","Hgd81.2 + Nitisinone POS":"122382","Hgd81.3 + Nitisinone POS":"123589","Hgd82.1 + Nitisinone POS":"95443","Hgd82.2 + Nitisinone POS":"103531","Hgd83.1 + Nitisinone POS":"151203","Hgd83.2 - No treatment POS":"127352","Hgd80.3 - No treatment POS":"111071","Hgd80.4 - No treatment POS":"102356","Hgd81.4 - No treatment POS":"151496","Hgd81.5 - No treatment POS":"110498","Hgd81.6 - No treatment POS":"134376","Hgd82.3 - No treatment POS":"151545","Hgd82.4 - No treatment POS":"115299","Hgd83.3 - No treatment POS":"112773","Hgd83.4 - No treatment POS":"136068"},{"Metabolite":"Petroselinic acid","Hgd80.2 + Nitisinone POS":"35404","Hgd81.1 + Nitisinone POS":"21421","Hgd81.2 + Nitisinone POS":"50788","Hgd81.3 + Nitisinone POS":"10013","Hgd82.1 + Nitisinone POS":"16049","Hgd82.2 + Nitisinone POS":"10111","Hgd83.1 + Nitisinone POS":"32735","Hgd83.2 - No treatment POS":"29385","Hgd80.3 - No treatment POS":"29136","Hgd80.4 - No treatment POS":"65847","Hgd81.4 - No treatment POS":"31300","Hgd81.5 - No treatment POS":"35682","Hgd81.6 - No treatment POS":"44761","Hgd82.3 - No treatment POS":"56559","Hgd82.4 - No treatment POS":"47787","Hgd83.3 - No treatment POS":"37487","Hgd83.4 - No treatment POS":"28311"},{"Metabolite":"L-Proline","Hgd80.2 + Nitisinone POS":"1240560","Hgd81.1 + Nitisinone POS":"787265","Hgd81.2 + Nitisinone POS":"786858","Hgd81.3 + Nitisinone POS":"888097","Hgd82.1 + Nitisinone POS":"1408531","Hgd82.2 + Nitisinone POS":"969542","Hgd83.1 + Nitisinone POS":"672960","Hgd83.2 - No treatment POS":"965627","Hgd80.3 - No treatment POS":"1135148","Hgd80.4 - No treatment POS":"1203924","Hgd81.4 - No treatment POS":"808566","Hgd81.5 - No treatment POS":"1135429","Hgd81.6 - No treatment POS":"1058275","Hgd82.3 - No treatment POS":"1881844","Hgd82.4 - No treatment POS":"1423480","Hgd83.3 - No treatment POS":"1080267","Hgd83.4 - No treatment POS":"1595876"},{"Metabolite":"Isocitrate","Hgd80.2 + Nitisinone POS":"289730","Hgd81.1 + Nitisinone POS":"120459","Hgd81.2 + Nitisinone POS":"239619","Hgd81.3 + Nitisinone POS":"178658","Hgd82.1 + Nitisinone POS":"155482","Hgd82.2 + Nitisinone POS":"303215","Hgd83.1 + Nitisinone POS":"168695","Hgd83.2 - No treatment POS":"297665","Hgd80.3 - No treatment POS":"137163","Hgd80.4 - No treatment POS":"147273","Hgd81.4 - No treatment POS":"163779","Hgd81.5 - No treatment POS":"248030","Hgd81.6 - No treatment POS":"290403","Hgd82.3 - No treatment POS":"571501","Hgd82.4 - No treatment POS":"320236","Hgd83.3 - No treatment POS":"218178","Hgd83.4 - No treatment POS":"227790"},{"Metabolite":"RAC-GLYCEROL 1-MYRISTATE","Hgd80.2 + Nitisinone POS":"6326","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"4189","Hgd81.3 + Nitisinone POS":"5997","Hgd82.1 + Nitisinone POS":"6658","Hgd82.2 + Nitisinone POS":"4264","Hgd83.1 + Nitisinone POS":"6997","Hgd83.2 - No treatment POS":"6266","Hgd80.3 - No treatment POS":"7702","Hgd80.4 - No treatment POS":"3859","Hgd81.4 - No treatment POS":"5598","Hgd81.5 - No treatment POS":"1","Hgd81.6 - No treatment POS":"6079","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"1","Hgd83.3 - No treatment POS":"6289","Hgd83.4 - No treatment POS":"5302"},{"Metabolite":"Glucosamine","Hgd80.2 + Nitisinone POS":"418728","Hgd81.1 + Nitisinone POS":"379238","Hgd81.2 + Nitisinone POS":"192566","Hgd81.3 + Nitisinone POS":"199201","Hgd82.1 + Nitisinone POS":"301297","Hgd82.2 + Nitisinone POS":"764079","Hgd83.1 + Nitisinone POS":"310352","Hgd83.2 - No treatment POS":"312291","Hgd80.3 - No treatment POS":"337509","Hgd80.4 - No treatment POS":"414061","Hgd81.4 - No treatment POS":"424808","Hgd81.5 - No treatment POS":"294307","Hgd81.6 - No treatment POS":"302410","Hgd82.3 - No treatment POS":"544740","Hgd82.4 - No treatment POS":"303492","Hgd83.3 - No treatment POS":"304609","Hgd83.4 - No treatment POS":"825528"},{"Metabolite":"Deoxyuridine monophosphate (dUMP)","Hgd80.2 + Nitisinone POS":"13409","Hgd81.1 + Nitisinone POS":"15836","Hgd81.2 + Nitisinone POS":"9764","Hgd81.3 + Nitisinone POS":"13130","Hgd82.1 + Nitisinone POS":"14160","Hgd82.2 + Nitisinone POS":"10301","Hgd83.1 + Nitisinone POS":"13724","Hgd83.2 - No treatment POS":"13589","Hgd80.3 - No treatment POS":"14078","Hgd80.4 - No treatment POS":"12703","Hgd81.4 - No treatment POS":"11049","Hgd81.5 - No treatment POS":"15439","Hgd81.6 - No treatment POS":"12618","Hgd82.3 - No treatment POS":"11672","Hgd82.4 - No treatment POS":"10720","Hgd83.3 - No treatment POS":"13795","Hgd83.4 - No treatment POS":"14174"},{"Metabolite":"Glycerol 2-phosphate","Hgd80.2 + Nitisinone POS":"99089","Hgd81.1 + Nitisinone POS":"93451","Hgd81.2 + Nitisinone POS":"114184","Hgd81.3 + Nitisinone POS":"170614","Hgd82.1 + Nitisinone POS":"122422","Hgd82.2 + Nitisinone POS":"152480","Hgd83.1 + Nitisinone POS":"101401","Hgd83.2 - No treatment POS":"105599","Hgd80.3 - No treatment POS":"141639","Hgd80.4 - No treatment POS":"139771","Hgd81.4 - No treatment POS":"113967","Hgd81.5 - No treatment POS":"121356","Hgd81.6 - No treatment POS":"126457","Hgd82.3 - No treatment POS":"68517","Hgd82.4 - No treatment POS":"141176","Hgd83.3 - No treatment POS":"115957","Hgd83.4 - No treatment POS":"106775"},{"Metabolite":"D-Sorbitol","Hgd80.2 + Nitisinone POS":"99461","Hgd81.1 + Nitisinone POS":"121823","Hgd81.2 + Nitisinone POS":"241108","Hgd81.3 + Nitisinone POS":"193481","Hgd82.1 + Nitisinone POS":"64188","Hgd82.2 + Nitisinone POS":"127342","Hgd83.1 + Nitisinone POS":"75775","Hgd83.2 - No treatment POS":"46056","Hgd80.3 - No treatment POS":"92228","Hgd80.4 - No treatment POS":"70614","Hgd81.4 - No treatment POS":"87297","Hgd81.5 - No treatment POS":"594383","Hgd81.6 - No treatment POS":"59927","Hgd82.3 - No treatment POS":"325857","Hgd82.4 - No treatment POS":"143663","Hgd83.3 - No treatment POS":"68757","Hgd83.4 - No treatment POS":"246722"},{"Metabolite":"METHYL BETA-D-GALACTOSIDE","Hgd80.2 + Nitisinone POS":"33955","Hgd81.1 + Nitisinone POS":"53491","Hgd81.2 + Nitisinone POS":"60288","Hgd81.3 + Nitisinone POS":"78831","Hgd82.1 + Nitisinone POS":"16656","Hgd82.2 + Nitisinone POS":"44700","Hgd83.1 + Nitisinone POS":"67635","Hgd83.2 - No treatment POS":"59832","Hgd80.3 - No treatment POS":"30337","Hgd80.4 - No treatment POS":"26508","Hgd81.4 - No treatment POS":"51807","Hgd81.5 - No treatment POS":"25166","Hgd81.6 - No treatment POS":"52199","Hgd82.3 - No treatment POS":"42804","Hgd82.4 - No treatment POS":"43891","Hgd83.3 - No treatment POS":"80729","Hgd83.4 - No treatment POS":"73374"},{"Metabolite":"?-D-Galactose 1-phosphate","Hgd80.2 + Nitisinone POS":"27883","Hgd81.1 + Nitisinone POS":"20768","Hgd81.2 + Nitisinone POS":"37869","Hgd81.3 + Nitisinone POS":"37592","Hgd82.1 + Nitisinone POS":"61973","Hgd82.2 + Nitisinone POS":"28845","Hgd83.1 + Nitisinone POS":"25591","Hgd83.2 - No treatment POS":"33211","Hgd80.3 - No treatment POS":"26223","Hgd80.4 - No treatment POS":"39443","Hgd81.4 - No treatment POS":"36361","Hgd81.5 - No treatment POS":"27718","Hgd81.6 - No treatment POS":"20945","Hgd82.3 - No treatment POS":"36053","Hgd82.4 - No treatment POS":"33442","Hgd83.3 - No treatment POS":"22877","Hgd83.4 - No treatment POS":"32939"},{"Metabolite":"D-Ribose 5-phosphate","Hgd80.2 + Nitisinone POS":"6170","Hgd81.1 + Nitisinone POS":"3431","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"17875","Hgd82.1 + Nitisinone POS":"38367","Hgd82.2 + Nitisinone POS":"15208","Hgd83.1 + Nitisinone POS":"1530","Hgd83.2 - No treatment POS":"350","Hgd80.3 - No treatment POS":"20345","Hgd80.4 - No treatment POS":"26713","Hgd81.4 - No treatment POS":"3689","Hgd81.5 - No treatment POS":"592","Hgd81.6 - No treatment POS":"1","Hgd82.3 - No treatment POS":"5521","Hgd82.4 - No treatment POS":"26871","Hgd83.3 - No treatment POS":"547","Hgd83.4 - No treatment POS":"2216"},{"Metabolite":"3-Hydroxyphenylacetic acid","Hgd80.2 + Nitisinone POS":"19006","Hgd81.1 + Nitisinone POS":"11295","Hgd81.2 + Nitisinone POS":"7511","Hgd81.3 + Nitisinone POS":"6964","Hgd82.1 + Nitisinone POS":"6206","Hgd82.2 + Nitisinone POS":"4491","Hgd83.1 + Nitisinone POS":"10062","Hgd83.2 - No treatment POS":"11819","Hgd80.3 - No treatment POS":"1","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"1","Hgd81.6 - No treatment POS":"1","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"1","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"1"},{"Metabolite":"Diaminopimelic acid","Hgd80.2 + Nitisinone POS":"13068","Hgd81.1 + Nitisinone POS":"15167","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"10680","Hgd82.1 + Nitisinone POS":"4793","Hgd82.2 + Nitisinone POS":"9257","Hgd83.1 + Nitisinone POS":"11929","Hgd83.2 - No treatment POS":"11515","Hgd80.3 - No treatment POS":"19586","Hgd80.4 - No treatment POS":"19058","Hgd81.4 - No treatment POS":"14431","Hgd81.5 - No treatment POS":"12849","Hgd81.6 - No treatment POS":"1","Hgd82.3 - No treatment POS":"23205","Hgd82.4 - No treatment POS":"13172","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"17298"},{"Metabolite":"Uridine","Hgd80.2 + Nitisinone POS":"445955","Hgd81.1 + Nitisinone POS":"587302","Hgd81.2 + Nitisinone POS":"394270","Hgd81.3 + Nitisinone POS":"474033","Hgd82.1 + Nitisinone POS":"619842","Hgd82.2 + Nitisinone POS":"523319","Hgd83.1 + Nitisinone POS":"666208","Hgd83.2 - No treatment POS":"695903","Hgd80.3 - No treatment POS":"580585","Hgd80.4 - No treatment POS":"562245","Hgd81.4 - No treatment POS":"625050","Hgd81.5 - No treatment POS":"631342","Hgd81.6 - No treatment POS":"603576","Hgd82.3 - No treatment POS":"617596","Hgd82.4 - No treatment POS":"681461","Hgd83.3 - No treatment POS":"672543","Hgd83.4 - No treatment POS":"682061"},{"Metabolite":"Caffeine","Hgd80.2 + Nitisinone POS":"86507","Hgd81.1 + Nitisinone POS":"53476","Hgd81.2 + Nitisinone POS":"80540","Hgd81.3 + Nitisinone POS":"51178","Hgd82.1 + Nitisinone POS":"66229","Hgd82.2 + Nitisinone POS":"27489","Hgd83.1 + Nitisinone POS":"58987","Hgd83.2 - No treatment POS":"74433","Hgd80.3 - No treatment POS":"72191","Hgd80.4 - No treatment POS":"56439","Hgd81.4 - No treatment POS":"46725","Hgd81.5 - No treatment POS":"85472","Hgd81.6 - No treatment POS":"255426","Hgd82.3 - No treatment POS":"22144","Hgd82.4 - No treatment POS":"47152","Hgd83.3 - No treatment POS":"50774","Hgd83.4 - No treatment POS":"49899"},{"Metabolite":"O-Phosphorylethanolamine","Hgd80.2 + Nitisinone POS":"9800","Hgd81.1 + Nitisinone POS":"10276","Hgd81.2 + Nitisinone POS":"15846","Hgd81.3 + Nitisinone POS":"21510","Hgd82.1 + Nitisinone POS":"15280","Hgd82.2 + Nitisinone POS":"28034","Hgd83.1 + Nitisinone POS":"12889","Hgd83.2 - No treatment POS":"15326","Hgd80.3 - No treatment POS":"12489","Hgd80.4 - No treatment POS":"22127","Hgd81.4 - No treatment POS":"15206","Hgd81.5 - No treatment POS":"15779","Hgd81.6 - No treatment POS":"16703","Hgd82.3 - No treatment POS":"9091","Hgd82.4 - No treatment POS":"18577","Hgd83.3 - No treatment POS":"12730","Hgd83.4 - No treatment POS":"14160"},{"Metabolite":"L-Norvaline","Hgd80.2 + Nitisinone POS":"780862","Hgd81.1 + Nitisinone POS":"539568","Hgd81.2 + Nitisinone POS":"471701","Hgd81.3 + Nitisinone POS":"503084","Hgd82.1 + Nitisinone POS":"605157","Hgd82.2 + Nitisinone POS":"499515","Hgd83.1 + Nitisinone POS":"544525","Hgd83.2 - No treatment POS":"642219","Hgd80.3 - No treatment POS":"657687","Hgd80.4 - No treatment POS":"569530","Hgd81.4 - No treatment POS":"547108","Hgd81.5 - No treatment POS":"800941","Hgd81.6 - No treatment POS":"715389","Hgd82.3 - No treatment POS":"576995","Hgd82.4 - No treatment POS":"1826","Hgd83.3 - No treatment POS":"634339","Hgd83.4 - No treatment POS":"635745"},{"Metabolite":"L-Leucine","Hgd80.2 + Nitisinone POS":"1366785","Hgd81.1 + Nitisinone POS":"1248563","Hgd81.2 + Nitisinone POS":"865529","Hgd81.3 + Nitisinone POS":"1034572","Hgd82.1 + Nitisinone POS":"1745832","Hgd82.2 + Nitisinone POS":"1182367","Hgd83.1 + Nitisinone POS":"1083663","Hgd83.2 - No treatment POS":"1458566","Hgd80.3 - No treatment POS":"1417130","Hgd80.4 - No treatment POS":"1277322","Hgd81.4 - No treatment POS":"1036614","Hgd81.5 - No treatment POS":"1607846","Hgd81.6 - No treatment POS":"1331533","Hgd82.3 - No treatment POS":"1057715","Hgd82.4 - No treatment POS":"1420164","Hgd83.3 - No treatment POS":"1431289","Hgd83.4 - No treatment POS":"1568522"},{"Metabolite":"Trigonelline","Hgd80.2 + Nitisinone POS":"237796","Hgd81.1 + Nitisinone POS":"243967","Hgd81.2 + Nitisinone POS":"169543","Hgd81.3 + Nitisinone POS":"194245","Hgd82.1 + Nitisinone POS":"252398","Hgd82.2 + Nitisinone POS":"255196","Hgd83.1 + Nitisinone POS":"246608","Hgd83.2 - No treatment POS":"283848","Hgd80.3 - No treatment POS":"294815","Hgd80.4 - No treatment POS":"328373","Hgd81.4 - No treatment POS":"269741","Hgd81.5 - No treatment POS":"352744","Hgd81.6 - No treatment POS":"311621","Hgd82.3 - No treatment POS":"1231363","Hgd82.4 - No treatment POS":"290950","Hgd83.3 - No treatment POS":"333746","Hgd83.4 - No treatment POS":"323527"},{"Metabolite":"Xylitol","Hgd80.2 + Nitisinone POS":"209690","Hgd81.1 + Nitisinone POS":"194341","Hgd81.2 + Nitisinone POS":"182293","Hgd81.3 + Nitisinone POS":"173086","Hgd82.1 + Nitisinone POS":"43195","Hgd82.2 + Nitisinone POS":"88843","Hgd83.1 + Nitisinone POS":"211035","Hgd83.2 - No treatment POS":"155810","Hgd80.3 - No treatment POS":"274643","Hgd80.4 - No treatment POS":"201029","Hgd81.4 - No treatment POS":"245813","Hgd81.5 - No treatment POS":"152948","Hgd81.6 - No treatment POS":"143206","Hgd82.3 - No treatment POS":"152253","Hgd82.4 - No treatment POS":"143710","Hgd83.3 - No treatment POS":"188886","Hgd83.4 - No treatment POS":"225755"},{"Metabolite":"Glutamyl-Tyrosine","Hgd80.2 + Nitisinone POS":"38763","Hgd81.1 + Nitisinone POS":"27781","Hgd81.2 + Nitisinone POS":"18637","Hgd81.3 + Nitisinone POS":"24045","Hgd82.1 + Nitisinone POS":"30095","Hgd82.2 + Nitisinone POS":"24243","Hgd83.1 + Nitisinone POS":"24128","Hgd83.2 - No treatment POS":"34167","Hgd80.3 - No treatment POS":"4199","Hgd80.4 - No treatment POS":"3730","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"4792","Hgd81.6 - No treatment POS":"3296","Hgd82.3 - No treatment POS":"24847","Hgd82.4 - No treatment POS":"4105","Hgd83.3 - No treatment POS":"5901","Hgd83.4 - No treatment POS":"7351"},{"Metabolite":"L-Arginine","Hgd80.2 + Nitisinone POS":"719830","Hgd81.1 + Nitisinone POS":"588361","Hgd81.2 + Nitisinone POS":"583241","Hgd81.3 + Nitisinone POS":"524708","Hgd82.1 + Nitisinone POS":"425052","Hgd82.2 + Nitisinone POS":"434875","Hgd83.1 + Nitisinone POS":"594700","Hgd83.2 - No treatment POS":"673097","Hgd80.3 - No treatment POS":"736464","Hgd80.4 - No treatment POS":"769029","Hgd81.4 - No treatment POS":"633215","Hgd81.5 - No treatment POS":"715437","Hgd81.6 - No treatment POS":"663594","Hgd82.3 - No treatment POS":"790716","Hgd82.4 - No treatment POS":"640376","Hgd83.3 - No treatment POS":"686799","Hgd83.4 - No treatment POS":"832491"},{"Metabolite":"5?-Deoxy-5?-(methylthio)adenosine","Hgd80.2 + Nitisinone POS":"23881","Hgd81.1 + Nitisinone POS":"27924","Hgd81.2 + Nitisinone POS":"15512","Hgd81.3 + Nitisinone POS":"17123","Hgd82.1 + Nitisinone POS":"41392","Hgd82.2 + Nitisinone POS":"18269","Hgd83.1 + Nitisinone POS":"23337","Hgd83.2 - No treatment POS":"26903","Hgd80.3 - No treatment POS":"25056","Hgd80.4 - No treatment POS":"33963","Hgd81.4 - No treatment POS":"21365","Hgd81.5 - No treatment POS":"24386","Hgd81.6 - No treatment POS":"32996","Hgd82.3 - No treatment POS":"28486","Hgd82.4 - No treatment POS":"25109","Hgd83.3 - No treatment POS":"26037","Hgd83.4 - No treatment POS":"24905"},{"Metabolite":"2-Deoxyglucose","Hgd80.2 + Nitisinone POS":"855902","Hgd81.1 + Nitisinone POS":"1251411","Hgd81.2 + Nitisinone POS":"660488","Hgd81.3 + Nitisinone POS":"688022","Hgd82.1 + Nitisinone POS":"397994","Hgd82.2 + Nitisinone POS":"533422","Hgd83.1 + Nitisinone POS":"782611","Hgd83.2 - No treatment POS":"684868","Hgd80.3 - No treatment POS":"1177109","Hgd80.4 - No treatment POS":"1094647","Hgd81.4 - No treatment POS":"840758","Hgd81.5 - No treatment POS":"978886","Hgd81.6 - No treatment POS":"929892","Hgd82.3 - No treatment POS":"1054803","Hgd82.4 - No treatment POS":"970744","Hgd83.3 - No treatment POS":"1280694","Hgd83.4 - No treatment POS":"1149305"},{"Metabolite":"L-Tyrosine","Hgd80.2 + Nitisinone POS":"6038927","Hgd81.1 + Nitisinone POS":"3903738","Hgd81.2 + Nitisinone POS":"3202107","Hgd81.3 + Nitisinone POS":"3059504","Hgd82.1 + Nitisinone POS":"3753154","Hgd82.2 + Nitisinone POS":"3166419","Hgd83.1 + Nitisinone POS":"3427897","Hgd83.2 - No treatment POS":"4290325","Hgd80.3 - No treatment POS":"509967","Hgd80.4 - No treatment POS":"535885","Hgd81.4 - No treatment POS":"446213","Hgd81.5 - No treatment POS":"608297","Hgd81.6 - No treatment POS":"490969","Hgd82.3 - No treatment POS":"408761","Hgd82.4 - No treatment POS":"610635","Hgd83.3 - No treatment POS":"689503","Hgd83.4 - No treatment POS":"751775"},{"Metabolite":"Deoxyguanosine","Hgd80.2 + Nitisinone POS":"1073354","Hgd81.1 + Nitisinone POS":"1249020","Hgd81.2 + Nitisinone POS":"9592584","Hgd81.3 + Nitisinone POS":"215730","Hgd82.1 + Nitisinone POS":"823376","Hgd82.2 + Nitisinone POS":"896599","Hgd83.1 + Nitisinone POS":"1331946","Hgd83.2 - No treatment POS":"3244738","Hgd80.3 - No treatment POS":"372430","Hgd80.4 - No treatment POS":"284084","Hgd81.4 - No treatment POS":"2251129","Hgd81.5 - No treatment POS":"863852","Hgd81.6 - No treatment POS":"9513782","Hgd82.3 - No treatment POS":"68700","Hgd82.4 - No treatment POS":"228664","Hgd83.3 - No treatment POS":"589816","Hgd83.4 - No treatment POS":"601080"},{"Metabolite":"N-acetylaspartate","Hgd80.2 + Nitisinone POS":"324547","Hgd81.1 + Nitisinone POS":"321204","Hgd81.2 + Nitisinone POS":"318871","Hgd81.3 + Nitisinone POS":"535930","Hgd82.1 + Nitisinone POS":"370255","Hgd82.2 + Nitisinone POS":"558106","Hgd83.1 + Nitisinone POS":"486829","Hgd83.2 - No treatment POS":"835096","Hgd80.3 - No treatment POS":"253002","Hgd80.4 - No treatment POS":"809402","Hgd81.4 - No treatment POS":"355373","Hgd81.5 - No treatment POS":"451879","Hgd81.6 - No treatment POS":"1096768","Hgd82.3 - No treatment POS":"252417","Hgd82.4 - No treatment POS":"529230","Hgd83.3 - No treatment POS":"506435","Hgd83.4 - No treatment POS":"420094"},{"Metabolite":"3-Methylglutaric acid","Hgd80.2 + Nitisinone POS":"134864","Hgd81.1 + Nitisinone POS":"71718","Hgd81.2 + Nitisinone POS":"38464","Hgd81.3 + Nitisinone POS":"351712","Hgd82.1 + Nitisinone POS":"144693","Hgd82.2 + Nitisinone POS":"76400","Hgd83.1 + Nitisinone POS":"136284","Hgd83.2 - No treatment POS":"685265","Hgd80.3 - No treatment POS":"105942","Hgd80.4 - No treatment POS":"80090","Hgd81.4 - No treatment POS":"111483","Hgd81.5 - No treatment POS":"150387","Hgd81.6 - No treatment POS":"85466","Hgd82.3 - No treatment POS":"246463","Hgd82.4 - No treatment POS":"245567","Hgd83.3 - No treatment POS":"118639","Hgd83.4 - No treatment POS":"225025"},{"Metabolite":"N-Acetylneuraminic Acid","Hgd80.2 + Nitisinone POS":"787798","Hgd81.1 + Nitisinone POS":"946528","Hgd81.2 + Nitisinone POS":"865256","Hgd81.3 + Nitisinone POS":"1064271","Hgd82.1 + Nitisinone POS":"541457","Hgd82.2 + Nitisinone POS":"836566","Hgd83.1 + Nitisinone POS":"977123","Hgd83.2 - No treatment POS":"894853","Hgd80.3 - No treatment POS":"1060679","Hgd80.4 - No treatment POS":"1024457","Hgd81.4 - No treatment POS":"1052720","Hgd81.5 - No treatment POS":"925977","Hgd81.6 - No treatment POS":"839118","Hgd82.3 - No treatment POS":"928057","Hgd82.4 - No treatment POS":"927295","Hgd83.3 - No treatment POS":"1002385","Hgd83.4 - No treatment POS":"968096"},{"Metabolite":"Octopamine (p-Hydroxyphenylethanolamine)","Hgd80.2 + Nitisinone POS":"21107","Hgd81.1 + Nitisinone POS":"18479","Hgd81.2 + Nitisinone POS":"14887","Hgd81.3 + Nitisinone POS":"13772","Hgd82.1 + Nitisinone POS":"10988","Hgd82.2 + Nitisinone POS":"12423","Hgd83.1 + Nitisinone POS":"17565","Hgd83.2 - No treatment POS":"17351","Hgd80.3 - No treatment POS":"21066","Hgd80.4 - No treatment POS":"20708","Hgd81.4 - No treatment POS":"18728","Hgd81.5 - No treatment POS":"16910","Hgd81.6 - No treatment POS":"16372","Hgd82.3 - No treatment POS":"20966","Hgd82.4 - No treatment POS":"18410","Hgd83.3 - No treatment POS":"20193","Hgd83.4 - No treatment POS":"19729"},{"Metabolite":"S-Adenosylhomocysteine","Hgd80.2 + Nitisinone POS":"10050","Hgd81.1 + Nitisinone POS":"12918","Hgd81.2 + Nitisinone POS":"7692","Hgd81.3 + Nitisinone POS":"16697","Hgd82.1 + Nitisinone POS":"61984","Hgd82.2 + Nitisinone POS":"18291","Hgd83.1 + Nitisinone POS":"13839","Hgd83.2 - No treatment POS":"16889","Hgd80.3 - No treatment POS":"17810","Hgd80.4 - No treatment POS":"23463","Hgd81.4 - No treatment POS":"15619","Hgd81.5 - No treatment POS":"17101","Hgd81.6 - No treatment POS":"28333","Hgd82.3 - No treatment POS":"12292","Hgd82.4 - No treatment POS":"47936","Hgd83.3 - No treatment POS":"15631","Hgd83.4 - No treatment POS":"17845"},{"Metabolite":"Riboflavin (Vitamin B2)","Hgd80.2 + Nitisinone POS":"8899","Hgd81.1 + Nitisinone POS":"8239","Hgd81.2 + Nitisinone POS":"3990","Hgd81.3 + Nitisinone POS":"5663","Hgd82.1 + Nitisinone POS":"3290","Hgd82.2 + Nitisinone POS":"6002","Hgd83.1 + Nitisinone POS":"7891","Hgd83.2 - No treatment POS":"8766","Hgd80.3 - No treatment POS":"6959","Hgd80.4 - No treatment POS":"6801","Hgd81.4 - No treatment POS":"5709","Hgd81.5 - No treatment POS":"8622","Hgd81.6 - No treatment POS":"9090","Hgd82.3 - No treatment POS":"6557","Hgd82.4 - No treatment POS":"4805","Hgd83.3 - No treatment POS":"8490","Hgd83.4 - No treatment POS":"8746"},{"Metabolite":"4-Hydroxyphenylpyruvic acid","Hgd80.2 + Nitisinone POS":"11499","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"1","Hgd82.1 + Nitisinone POS":"15602","Hgd82.2 + Nitisinone POS":"1","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"1","Hgd80.3 - No treatment POS":"1","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"1","Hgd81.6 - No treatment POS":"9326","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"1","Hgd83.3 - No treatment POS":"7837","Hgd83.4 - No treatment POS":"17085"},{"Metabolite":"2-Methylglutaric acid","Hgd80.2 + Nitisinone POS":"134864","Hgd81.1 + Nitisinone POS":"71802","Hgd81.2 + Nitisinone POS":"41831","Hgd81.3 + Nitisinone POS":"351712","Hgd82.1 + Nitisinone POS":"144693","Hgd82.2 + Nitisinone POS":"76825","Hgd83.1 + Nitisinone POS":"136343","Hgd83.2 - No treatment POS":"685276","Hgd80.3 - No treatment POS":"105935","Hgd80.4 - No treatment POS":"84112","Hgd81.4 - No treatment POS":"116688","Hgd81.5 - No treatment POS":"150378","Hgd81.6 - No treatment POS":"85646","Hgd82.3 - No treatment POS":"246298","Hgd82.4 - No treatment POS":"245629","Hgd83.3 - No treatment POS":"118716","Hgd83.4 - No treatment POS":"224994"},{"Metabolite":"Adenine","Hgd80.2 + Nitisinone POS":"4685311","Hgd81.1 + Nitisinone POS":"4213022","Hgd81.2 + Nitisinone POS":"3256026","Hgd81.3 + Nitisinone POS":"3436828","Hgd82.1 + Nitisinone POS":"3731929","Hgd82.2 + Nitisinone POS":"3976501","Hgd83.1 + Nitisinone POS":"4443544","Hgd83.2 - No treatment POS":"5147027","Hgd80.3 - No treatment POS":"3781000","Hgd80.4 - No treatment POS":"3718905","Hgd81.4 - No treatment POS":"3878207","Hgd81.5 - No treatment POS":"5033695","Hgd81.6 - No treatment POS":"4386665","Hgd82.3 - No treatment POS":"4120257","Hgd82.4 - No treatment POS":"4152212","Hgd83.3 - No treatment POS":"5207635","Hgd83.4 - No treatment POS":"4734669"},{"Metabolite":"Pyroglutamic acid","Hgd80.2 + Nitisinone POS":"1248581","Hgd81.1 + Nitisinone POS":"953252","Hgd81.2 + Nitisinone POS":"951719","Hgd81.3 + Nitisinone POS":"672756","Hgd82.1 + Nitisinone POS":"1182774","Hgd82.2 + Nitisinone POS":"817781","Hgd83.1 + Nitisinone POS":"695407","Hgd83.2 - No treatment POS":"904925","Hgd80.3 - No treatment POS":"1073549","Hgd80.4 - No treatment POS":"777653","Hgd81.4 - No treatment POS":"968436","Hgd81.5 - No treatment POS":"942993","Hgd81.6 - No treatment POS":"1199085","Hgd82.3 - No treatment POS":"777922","Hgd82.4 - No treatment POS":"1012899","Hgd83.3 - No treatment POS":"1242077","Hgd83.4 - No treatment POS":"808480"},{"Metabolite":"Uracil","Hgd80.2 + Nitisinone POS":"49645","Hgd81.1 + Nitisinone POS":"69196","Hgd81.2 + Nitisinone POS":"44440","Hgd81.3 + Nitisinone POS":"54237","Hgd82.1 + Nitisinone POS":"65129","Hgd82.2 + Nitisinone POS":"77469","Hgd83.1 + Nitisinone POS":"62309","Hgd83.2 - No treatment POS":"71676","Hgd80.3 - No treatment POS":"57868","Hgd80.4 - No treatment POS":"39023","Hgd81.4 - No treatment POS":"53911","Hgd81.5 - No treatment POS":"75507","Hgd81.6 - No treatment POS":"60674","Hgd82.3 - No treatment POS":"38797","Hgd82.4 - No treatment POS":"47372","Hgd83.3 - No treatment POS":"61007","Hgd83.4 - No treatment POS":"55904"},{"Metabolite":"Carnitine","Hgd80.2 + Nitisinone POS":"2151584","Hgd81.1 + Nitisinone POS":"2106837","Hgd81.2 + Nitisinone POS":"1380844","Hgd81.3 + Nitisinone POS":"2755657","Hgd82.1 + Nitisinone POS":"1.01E+07","Hgd82.2 + Nitisinone POS":"4155693","Hgd83.1 + Nitisinone POS":"2283134","Hgd83.2 - No treatment POS":"2861165","Hgd80.3 - No treatment POS":"2306673","Hgd80.4 - No treatment POS":"2841788","Hgd81.4 - No treatment POS":"2478362","Hgd81.5 - No treatment POS":"2698669","Hgd81.6 - No treatment POS":"2891915","Hgd82.3 - No treatment POS":"2282963","Hgd82.4 - No treatment POS":"3499471","Hgd83.3 - No treatment POS":"2838670","Hgd83.4 - No treatment POS":"2591990"},{"Metabolite":"L-Valine","Hgd80.2 + Nitisinone POS":"780862","Hgd81.1 + Nitisinone POS":"539568","Hgd81.2 + Nitisinone POS":"468347","Hgd81.3 + Nitisinone POS":"503854","Hgd82.1 + Nitisinone POS":"605157","Hgd82.2 + Nitisinone POS":"499515","Hgd83.1 + Nitisinone POS":"544525","Hgd83.2 - No treatment POS":"577092","Hgd80.3 - No treatment POS":"657687","Hgd80.4 - No treatment POS":"586462","Hgd81.4 - No treatment POS":"547552","Hgd81.5 - No treatment POS":"800941","Hgd81.6 - No treatment POS":"722525","Hgd82.3 - No treatment POS":"576995","Hgd82.4 - No treatment POS":"576825","Hgd83.3 - No treatment POS":"634339","Hgd83.4 - No treatment POS":"635745"},{"Metabolite":"1-Aminocyclopropane-1-carboxylic acid","Hgd80.2 + Nitisinone POS":"20321","Hgd81.1 + Nitisinone POS":"18524","Hgd81.2 + Nitisinone POS":"16502","Hgd81.3 + Nitisinone POS":"9583","Hgd82.1 + Nitisinone POS":"11444","Hgd82.2 + Nitisinone POS":"9490","Hgd83.1 + Nitisinone POS":"17915","Hgd83.2 - No treatment POS":"16768","Hgd80.3 - No treatment POS":"15922","Hgd80.4 - No treatment POS":"13925","Hgd81.4 - No treatment POS":"12281","Hgd81.5 - No treatment POS":"15579","Hgd81.6 - No treatment POS":"16363","Hgd82.3 - No treatment POS":"18628","Hgd82.4 - No treatment POS":"12248","Hgd83.3 - No treatment POS":"19172","Hgd83.4 - No treatment POS":"16363"},{"Metabolite":"10-hydroxy capric acid","Hgd80.2 + Nitisinone POS":"32460","Hgd81.1 + Nitisinone POS":"23545","Hgd81.2 + Nitisinone POS":"34322","Hgd81.3 + Nitisinone POS":"58148","Hgd82.1 + Nitisinone POS":"34162","Hgd82.2 + Nitisinone POS":"33610","Hgd83.1 + Nitisinone POS":"34777","Hgd83.2 - No treatment POS":"114090","Hgd80.3 - No treatment POS":"28563","Hgd80.4 - No treatment POS":"54431","Hgd81.4 - No treatment POS":"27225","Hgd81.5 - No treatment POS":"27185","Hgd81.6 - No treatment POS":"27806","Hgd82.3 - No treatment POS":"52722","Hgd82.4 - No treatment POS":"70907","Hgd83.3 - No treatment POS":"25491","Hgd83.4 - No treatment POS":"25076"},{"Metabolite":"Erythritol","Hgd80.2 + Nitisinone POS":"135207","Hgd81.1 + Nitisinone POS":"172514","Hgd81.2 + Nitisinone POS":"257941","Hgd81.3 + Nitisinone POS":"193322","Hgd82.1 + Nitisinone POS":"62063","Hgd82.2 + Nitisinone POS":"122851","Hgd83.1 + Nitisinone POS":"160253","Hgd83.2 - No treatment POS":"114516","Hgd80.3 - No treatment POS":"234040","Hgd80.4 - No treatment POS":"43662","Hgd81.4 - No treatment POS":"273850","Hgd81.5 - No treatment POS":"40546","Hgd81.6 - No treatment POS":"139093","Hgd82.3 - No treatment POS":"69984","Hgd82.4 - No treatment POS":"35150","Hgd83.3 - No treatment POS":"141541","Hgd83.4 - No treatment POS":"42384"},{"Metabolite":"Chenodeoxycholic Acid","Hgd80.2 + Nitisinone POS":"325025","Hgd81.1 + Nitisinone POS":"330100","Hgd81.2 + Nitisinone POS":"310924","Hgd81.3 + Nitisinone POS":"289885","Hgd82.1 + Nitisinone POS":"245478","Hgd82.2 + Nitisinone POS":"297262","Hgd83.1 + Nitisinone POS":"300940","Hgd83.2 - No treatment POS":"263860","Hgd80.3 - No treatment POS":"307355","Hgd80.4 - No treatment POS":"315898","Hgd81.4 - No treatment POS":"263790","Hgd81.5 - No treatment POS":"293772","Hgd81.6 - No treatment POS":"300664","Hgd82.3 - No treatment POS":"305759","Hgd82.4 - No treatment POS":"354653","Hgd83.3 - No treatment POS":"295998","Hgd83.4 - No treatment POS":"258040"},{"Metabolite":"DL-3-amino-isobutanoic acid","Hgd80.2 + Nitisinone POS":"6317","Hgd81.1 + Nitisinone POS":"7422","Hgd81.2 + Nitisinone POS":"19427","Hgd81.3 + Nitisinone POS":"50217","Hgd82.1 + Nitisinone POS":"31653","Hgd82.2 + Nitisinone POS":"70764","Hgd83.1 + Nitisinone POS":"21657","Hgd83.2 - No treatment POS":"18670","Hgd80.3 - No treatment POS":"20266","Hgd80.4 - No treatment POS":"43558","Hgd81.4 - No treatment POS":"17927","Hgd81.5 - No treatment POS":"25601","Hgd81.6 - No treatment POS":"28207","Hgd82.3 - No treatment POS":"13607","Hgd82.4 - No treatment POS":"48739","Hgd83.3 - No treatment POS":"29985","Hgd83.4 - No treatment POS":"25522"},{"Metabolite":"N-ALPHA-ACETYL-L-ASPARAGINE","Hgd80.2 + Nitisinone POS":"224029","Hgd81.1 + Nitisinone POS":"253772","Hgd81.2 + Nitisinone POS":"141238","Hgd81.3 + Nitisinone POS":"206707","Hgd82.1 + Nitisinone POS":"168838","Hgd82.2 + Nitisinone POS":"207093","Hgd83.1 + Nitisinone POS":"226978","Hgd83.2 - No treatment POS":"235929","Hgd80.3 - No treatment POS":"245821","Hgd80.4 - No treatment POS":"208458","Hgd81.4 - No treatment POS":"221492","Hgd81.5 - No treatment POS":"250622","Hgd81.6 - No treatment POS":"193959","Hgd82.3 - No treatment POS":"270835","Hgd82.4 - No treatment POS":"280103","Hgd83.3 - No treatment POS":"247126","Hgd83.4 - No treatment POS":"379049"},{"Metabolite":"Monomethyl glutaric acid","Hgd80.2 + Nitisinone POS":"1","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"1574","Hgd81.3 + Nitisinone POS":"16807","Hgd82.1 + Nitisinone POS":"4422","Hgd82.2 + Nitisinone POS":"1","Hgd83.1 + Nitisinone POS":"6498","Hgd83.2 - No treatment POS":"38293","Hgd80.3 - No treatment POS":"2197","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"5120","Hgd81.5 - No treatment POS":"2617","Hgd81.6 - No treatment POS":"4475","Hgd82.3 - No treatment POS":"9385","Hgd82.4 - No treatment POS":"10470","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"1"},{"Metabolite":"Succinylacetone HT-1","Hgd80.2 + Nitisinone POS":"1","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"8439","Hgd82.1 + Nitisinone POS":"1","Hgd82.2 + Nitisinone POS":"1","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"20494","Hgd80.3 - No treatment POS":"1","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"1","Hgd81.6 - No treatment POS":"1","Hgd82.3 - No treatment POS":"10792","Hgd82.4 - No treatment POS":"6509","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"1"},{"Metabolite":"Glyceraldehyde","Hgd80.2 + Nitisinone POS":"1","Hgd81.1 + Nitisinone POS":"18338","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"17164","Hgd82.1 + Nitisinone POS":"1","Hgd82.2 + Nitisinone POS":"1","Hgd83.1 + Nitisinone POS":"20391","Hgd83.2 - No treatment POS":"1","Hgd80.3 - No treatment POS":"1","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"20755","Hgd81.5 - No treatment POS":"1","Hgd81.6 - No treatment POS":"1","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"1","Hgd83.3 - No treatment POS":"22172","Hgd83.4 - No treatment POS":"1"},{"Metabolite":"Uridine monophosphate (UMP)","Hgd80.2 + Nitisinone POS":"1","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"1","Hgd82.1 + Nitisinone POS":"20919","Hgd82.2 + Nitisinone POS":"3985","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"1","Hgd80.3 - No treatment POS":"2494","Hgd80.4 - No treatment POS":"5098","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"1","Hgd81.6 - No treatment POS":"1","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"6682","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"1"},{"Metabolite":"Dihydrouracil","Hgd80.2 + Nitisinone POS":"1","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"1","Hgd82.1 + Nitisinone POS":"1","Hgd82.2 + Nitisinone POS":"13308","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"1","Hgd80.3 - No treatment POS":"1","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"1","Hgd81.6 - No treatment POS":"1","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"1","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"1"},{"Metabolite":"5-Methylcytosine","Hgd80.2 + Nitisinone POS":"1","Hgd81.1 + Nitisinone POS":"1","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"1","Hgd82.1 + Nitisinone POS":"3739","Hgd82.2 + Nitisinone POS":"1","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"1","Hgd80.3 - No treatment POS":"1","Hgd80.4 - No treatment POS":"1","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"1","Hgd81.6 - No treatment POS":"1","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"1","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"1"},{"Metabolite":"Pyridoxal Phosphate","Hgd80.2 + Nitisinone POS":"1","Hgd81.1 + Nitisinone POS":"3117","Hgd81.2 + Nitisinone POS":"1","Hgd81.3 + Nitisinone POS":"1","Hgd82.1 + Nitisinone POS":"1","Hgd82.2 + Nitisinone POS":"1","Hgd83.1 + Nitisinone POS":"1","Hgd83.2 - No treatment POS":"1","Hgd80.3 - No treatment POS":"1","Hgd80.4 - No treatment POS":"6298","Hgd81.4 - No treatment POS":"1","Hgd81.5 - No treatment POS":"1","Hgd81.6 - No treatment POS":"1","Hgd82.3 - No treatment POS":"1","Hgd82.4 - No treatment POS":"1","Hgd83.3 - No treatment POS":"1","Hgd83.4 - No treatment POS":"1"}],

"Metabolites":[{"Metabolite":"L-Histidine","Mass":"155.0697","Retention Time":"1.257","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"71-00-1"},{"Metabolite":"Inosine","Mass":"268.0809","Retention Time":"2.9869998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"58-63-9"},{"Metabolite":"Adipic acid","Mass":"146.058","Retention Time":"4.713","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"124-04-9"},{"Metabolite":"Sarcosine","Mass":"89.048","Retention Time":"1.3640002","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"107-97-1"},{"Metabolite":"6-Deoxy-L-galactose","Mass":"164.0686","Retention Time":"1.4799998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"2438-80-4"},{"Metabolite":"L-Pipecolic acid","Mass":"129.079","Retention Time":"1.719","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"3105-95-1"},{"Metabolite":"Ethylmalonic acid","Mass":"132.0422","Retention Time":"3.9780004","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"601-75-2"},{"Metabolite":"D-(-)-Lyxose","Mass":"150.0529","Retention Time":"1.434","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"1114-34-7"},{"Metabolite":"Theobromine","Mass":"180.0648","Retention Time":"4.611","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"83-67-0"},{"Metabolite":"Hippuric acid","Mass":"179.0586","Retention Time":"5.629","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"495-69-2"},{"Metabolite":"Oleic Acid","Mass":"282.256","Retention Time":"13.3150015","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"112-80-1"},{"Metabolite":"3,4-Dihydroxybenzoic acid","Mass":"154.0244","Retention Time":"4.1679997","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"99-50-3"},{"Metabolite":"Kynurenine","Mass":"208.0849","Retention Time":"3.51","Ion Species":"[M+H]+","CAS Number":"343-65-7"},{"Metabolite":"Methyl jasmonate","Mass":"224.1411","Retention Time":"10.373","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"39924-52-2"},{"Metabolite":"Thiamine monophosphate","Mass":"344.0703","Retention Time":"1.2840002","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"532-40-1"},{"Metabolite":"Dulcitol","Mass":"182.079","Retention Time":"1.3500003","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"608-66-2"},{"Metabolite":"myo-Inositol","Mass":"180.0637","Retention Time":"1.4160002","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"87-9-8"},{"Metabolite":"Hypoxanthine","Mass":"136.0393","Retention Time":"2.1650004","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"68-94-0"},{"Metabolite":"Phosphocreatine","Mass":"211.0358","Retention Time":"1.419","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"67-07-2"},{"Metabolite":"Thymidine","Mass":"242.0902","Retention Time":"3.9780004","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"50-89-5"},{"Metabolite":"1-methylhistidine","Mass":"169.0853","Retention Time":"1.2749999","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"332-80-9"},{"Metabolite":"DL-pipecolic acid","Mass":"129.079","Retention Time":"1.719","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"535-75-1"},{"Metabolite":"4-acetamidobutanoate","Mass":"145.0742","Retention Time":"3.2809992","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"3025-96-5"},{"Metabolite":"Theophylline","Mass":"180.0648","Retention Time":"5.1080008","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"58-55-9"},{"Metabolite":"L-Tryptophan","Mass":"204.0899","Retention Time":"4.611","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"73-22-3"},{"Metabolite":"Niacinamide","Mass":"122.0485","Retention Time":"2.4039998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"98-92-0"},{"Metabolite":"Cytidine","Mass":"243.0862","Retention Time":"1.5179998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"65-46-3"},{"Metabolite":"L-Threonine","Mass":"119.0586","Retention Time":"1.324","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"72-19-5"},{"Metabolite":"Malic acid","Mass":"134.0215","Retention Time":"1.625","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"6915-15-7"},{"Metabolite":"L-Isoleucine","Mass":"131.095","Retention Time":"2.4900002","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"73-32-5"},{"Metabolite":"N-Acetyl-L-glutamic acid","Mass":"189.0636","Retention Time":"2.2970004","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"1188-37-0"},{"Metabolite":"D-Mannitol","Mass":"182.079","Retention Time":"1.3500003","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"69-65-8"},{"Metabolite":"L-Aspartic Acid","Mass":"133.0375","Retention Time":"1.462","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"56-84-8"},{"Metabolite":"Adenosine","Mass":"267.097","Retention Time":"3.1959996","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"58-61-7"},{"Metabolite":"5-Hydroxyindoleacetic acid","Mass":"191.0593","Retention Time":"5.0950003","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"54-16-0"},{"Metabolite":"Creatine","Mass":"131.0702","Retention Time":"1.367","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"57-00-1"},{"Metabolite":"2-Aminoisobutyric acid","Mass":"103.0636","Retention Time":"1.279","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"62-57-7"},{"Metabolite":"Acetyl-L-tyrosine","Mass":"223.0842","Retention Time":"5.0619993","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"537-55-3"},{"Metabolite":"p-Hydroxyphenylacetic acid","Mass":"152.047","Retention Time":"5.493","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"156-38-7"},{"Metabolite":"Quinic acid","Mass":"192.0643","Retention Time":"1.433","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"77-95-2"},{"Metabolite":"Methyl N-(a-methylbutyryl)glycine","Mass":"188.1052","Retention Time":"8.21","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"123-99-9"},{"Metabolite":"3-Methyladenine","Mass":"149.0694","Retention Time":"1.4379998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"5142-23-4"},{"Metabolite":"Maleamic acid","Mass":"115.0269","Retention Time":"1.571","Ion Species":"[M+H]+","CAS Number":"557-24-4"},{"Metabolite":"D-Aspartic acid","Mass":"133.0375","Retention Time":"1.4599998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"1783-96-6"},{"Metabolite":"12-Hydroxydodecanoic acid","Mass":"216.1725","Retention Time":"10.639002","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"505-95-3"},{"Metabolite":"Histamine","Mass":"111.0801","Retention Time":"1.06","Ion Species":"[M+H]+","CAS Number":"51-45-6"},{"Metabolite":"Pantothenic Acid","Mass":"219.1112","Retention Time":"4.364999","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"137-08-6"},{"Metabolite":"3-Ureidopropionic acid","Mass":"132.0537","Retention Time":"1.7450004","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"462-88-4"},{"Metabolite":"L-(-)-Arabitol","Mass":"152.0686","Retention Time":"1.4109999","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"7643-75-6"},{"Metabolite":"Glutamine","Mass":"146.0697","Retention Time":"1.325","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"56-85-9"},{"Metabolite":"2-Deoxy-D-Ribose","Mass":"134.0602","Retention Time":"8.989999","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"533-67-5"},{"Metabolite":"salsolinol","Mass":"179.094","Retention Time":"2.0989995","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"27740-96-1"},{"Metabolite":"Creatinine","Mass":"113.0594","Retention Time":"1.309","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"60-27-5"},{"Metabolite":"Cytosine","Mass":"111.044","Retention Time":"1.5160002","Ion Species":"[M+H]+","CAS Number":"71-30-7"},{"Metabolite":"Adenosine5'-monophosphate","Mass":"347.0626","Retention Time":"1.7999997","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"149022-20-8"},{"Metabolite":"D-Mannose 6-phosphate","Mass":"260.0298","Retention Time":"1.3419998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"3672-15-9"},{"Metabolite":"a-N-Acetylglucosamine","Mass":"221.0901","Retention Time":"1.465","Ion Species":"[M+H]+ [M+K]+","CAS Number":"7512-17-6"},{"Metabolite":"L-Alanine","Mass":"89.048","Retention Time":"1.3640002","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"56-41-7"},{"Metabolite":"N-Acetyl-DL-serine","Mass":"147.0533","Retention Time":"1.6879998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"94-14-3"},{"Metabolite":"N-Formylmethionine","Mass":"177.046","Retention Time":"4.602","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"4289-98-9"},{"Metabolite":"N-Acetyl-DL-methionine","Mass":"191.0593","Retention Time":"5.0950003","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"1115-47-5"},{"Metabolite":"Diacetyl","Mass":"86.0369","Retention Time":"9.615999","Ion Species":"[M+H]+","CAS Number":"431-03-8"},{"Metabolite":"1-Methyladenosine","Mass":"281.1123","Retention Time":"4.383","Ion Species":"[M+H]+ [M+K]+","CAS Number":"15763-06-1"},{"Metabolite":"Xanthurenic acid","Mass":"205.0373","Retention Time":"5.204","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"59-00-7"},{"Metabolite":"L-Anserine","Mass":"240.1222","Retention Time":"1.265","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"10030-52-1"},{"Metabolite":"D-Fructose 6-phosphate","Mass":"260.0298","Retention Time":"1.3419998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"643-13-0"},{"Metabolite":"Diethanolamine","Mass":"105.0792","Retention Time":"1.273","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"111-42-2"},{"Metabolite":"Pimelic acid","Mass":"160.0737","Retention Time":"5.997001","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"111-16-0"},{"Metabolite":"Suberic acid","Mass":"174.0895","Retention Time":"7.1869984","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"505-48-6"},{"Metabolite":"D-MANNOSAMINE","Mass":"179.0796","Retention Time":"1.3460001","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"5505-63-5"},{"Metabolite":"D-Ribose","Mass":"150.0529","Retention Time":"1.434","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"50-69-1"},{"Metabolite":"Deoxycytidine","Mass":"227.0907","Retention Time":"1.6369996","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"951-77-9"},{"Metabolite":"N-Methyl-D-aspartic acid","Mass":"147.0535","Retention Time":"1.3310001","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"6384-92-5"},{"Metabolite":"?-D-Glucose 1-phosphate","Mass":"260.0298","Retention Time":"1.3419998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"59-56-3"},{"Metabolite":"S-(5-ADENOSYL)-L-METHIONINE","Mass":"398.1365","Retention Time":"1.2840002","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"17176-17-9"},{"Metabolite":"Xanthine","Mass":"152.0335","Retention Time":"2.3740003","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"69-89-6"},{"Metabolite":"Glyceryl phosphate","Mass":"172.0138","Retention Time":"1.426","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"57-03-4"},{"Metabolite":"L-Norleucine","Mass":"131.095","Retention Time":"2.4900002","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"327-57-1"},{"Metabolite":"L-Serine","Mass":"105.0428","Retention Time":"1.2819998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"56-45-1"},{"Metabolite":"Xanthosine","Mass":"284.0751","Retention Time":"3.5380006","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"146-80-5"},{"Metabolite":"D-Ornithine","Mass":"132.0901","Retention Time":"1.104","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"348-66-3"},{"Metabolite":"D-(+)-Xylose","Mass":"150.0529","Retention Time":"1.434","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"58-86-6"},{"Metabolite":"Corticosterone","Mass":"346.2143","Retention Time":"10.036001","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"50-22-6"},{"Metabolite":"N-Acetyl-?-D-mannosamine","Mass":"221.0901","Retention Time":"1.465","Ion Species":"[M+H]+ [M+K]+","CAS Number":"7772-94-3"},{"Metabolite":"DL-Homoserine","Mass":"119.0586","Retention Time":"1.324","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"1927-25-9"},{"Metabolite":"D-(+)-Malic acid","Mass":"134.0215","Retention Time":"1.6240001","Ion Species":"[M+K]+ [M+Na]+","CAS Number":"636-61-3"},{"Metabolite":"4-Pyridoxic acid","Mass":"183.0533","Retention Time":"3.271","Ion Species":"[M+H]+","CAS Number":"82-82-6"},{"Metabolite":"Dihydroxyphenylacetic acid","Mass":"168.04","Retention Time":"4.713","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"102-32-9"},{"Metabolite":"D-Glucosamine 6-phosphate","Mass":"259.0459","Retention Time":"1.479","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"3616-42-0"},{"Metabolite":"N-Methylhistamine","Mass":"125.0957","Retention Time":"1.092","Ion Species":"[M+H]+ [M+K]+","CAS Number":"673-50-7"},{"Metabolite":"Ketoleucine","Mass":"130.0631","Retention Time":"4.985","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"816-66-0"},{"Metabolite":"AHBA","Mass":"153.0404","Retention Time":"2.616","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"76045-71-1"},{"Metabolite":"L-Phenylalanine","Mass":"165.0794","Retention Time":"3.8189998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"63-91-2"},{"Metabolite":"3-hydroxy-3-methyl-Glutaric acid","Mass":"162.0527","Retention Time":"2.7960002","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"503-49-1"},{"Metabolite":"L-Methionine","Mass":"149.0516","Retention Time":"1.868","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"63-68-3"},{"Metabolite":"N-Acetyl-D-galactosamine","Mass":"221.0901","Retention Time":"1.465","Ion Species":"[M+H]+ [M+K]+","CAS Number":"1811-31-0"},{"Metabolite":"N-Acetyl-L-alanine","Mass":"131.0587","Retention Time":"2.616","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"97-69-8"},{"Metabolite":"3-Methoxy-4-hydroxyphenylethylene glycol","Mass":"184.0736","Retention Time":"3.7809992","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"67423-45-4"},{"Metabolite":"Ribitol","Mass":"152.0686","Retention Time":"1.4109999","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"488-81-3"},{"Metabolite":"?-Aminobutryic acid","Mass":"103.0636","Retention Time":"1.279","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"56-12-2"},{"Metabolite":"Cortexolone","Mass":"346.2143","Retention Time":"10.036001","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"152-58-9"},{"Metabolite":"Spermidine","Mass":"145.1583","Retention Time":"0.97500014","Ion Species":"[M+H]+","CAS Number":"124-20-9"},{"Metabolite":"R-(-)-Mandelic acid","Mass":"152.0451","Retention Time":"4.801","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"90-64-2"},{"Metabolite":"4-Hydroxy-L-phenylglycine","Mass":"167.0582","Retention Time":"1.4659997","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"32462-30-9"},{"Metabolite":"Inosine 5'-monophosphate (IMP)","Mass":"348.0471","Retention Time":"1.9330001","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"131-99-7"},{"Metabolite":"Pyridoxamine","Mass":"168.0875","Retention Time":"1.12","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"85-87-0"},{"Metabolite":"Taurine","Mass":"125.0149","Retention Time":"1.2959998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"107-35-7"},{"Metabolite":"N?,N?,N?-Trimethyllysine","Mass":"189.1561","Retention Time":"1.2679999","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"55528-53-5"},{"Metabolite":"L-Ornithine","Mass":"132.0901","Retention Time":"1.104","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"3184-13-2"},{"Metabolite":"L-Asparagine","Mass":"132.0534","Retention Time":"1.286","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"70-47-3"},{"Metabolite":"Urocanic acid","Mass":"138.0435","Retention Time":"1.6900004","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"104-98-3"},{"Metabolite":"D-Glucose 6-phosphate","Mass":"260.0298","Retention Time":"1.3419998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"56-73-5"},{"Metabolite":"L-(-)Sorbose","Mass":"180.0637","Retention Time":"1.4169999","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"87-79-6"},{"Metabolite":"3-Amino-4-hydroxybenzoic acid","Mass":"153.0404","Retention Time":"2.616","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"1571-72-8"},{"Metabolite":"Guanine","Mass":"151.0484","Retention Time":"1.861","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"73-40-5"},{"Metabolite":"L-Lysine","Mass":"146.1057","Retention Time":"1.1090001","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"56-87-1"},{"Metabolite":"Allothreonine","Mass":"119.0586","Retention Time":"1.324","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"144-98-9"},{"Metabolite":"Citrulline","Mass":"175.096","Retention Time":"1.3290002","Ion Species":"[M+H]+ [M+K]+","CAS Number":"372-75-8"},{"Metabolite":"D-Tryptophan","Mass":"204.0899","Retention Time":"4.611","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"153-94-6"},{"Metabolite":"D-Alanine","Mass":"89.048","Retention Time":"1.3640002","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"338-69-2"},{"Metabolite":"(-)-Epinephrine","Mass":"183.0872","Retention Time":"1.2910001","Ion Species":"[M+H]+","CAS Number":"51-43-4"},{"Metabolite":"O-Acetylserine","Mass":"147.0533","Retention Time":"1.6879998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"5147-00-2"},{"Metabolite":"Petroselinic acid","Mass":"282.256","Retention Time":"13.3150015","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"593-39-5"},{"Metabolite":"L-Proline","Mass":"115.0643","Retention Time":"1.4470003","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"147-85-3"},{"Metabolite":"Isocitrate","Mass":"192.0269","Retention Time":"1.9160001","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"320-77-4"},{"Metabolite":"RAC-GLYCEROL 1-MYRISTATE","Mass":"302.245","Retention Time":"13.242997","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"589-68-4"},{"Metabolite":"Glucosamine","Mass":"179.0796","Retention Time":"1.3460001","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"3416-24-8"},{"Metabolite":"Deoxyuridine monophosphate (dUMP)","Mass":"308.0419","Retention Time":"1.944","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"964-26-1"},{"Metabolite":"Glycerol 2-phosphate","Mass":"172.0138","Retention Time":"1.426","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"17181-54-3"},{"Metabolite":"D-Sorbitol","Mass":"182.079","Retention Time":"1.3500003","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"50-70-4"},{"Metabolite":"METHYL BETA-D-GALACTOSIDE","Mass":"194.0788","Retention Time":"1.6800002","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"1824-94-8"},{"Metabolite":"?-D-Galactose 1-phosphate","Mass":"260.0298","Retention Time":"1.3419998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"2255-14-3"},{"Metabolite":"D-Ribose 5-phosphate","Mass":"230.0193","Retention Time":"1.4150002","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"4300-28-1"},{"Metabolite":"3-Hydroxyphenylacetic acid","Mass":"152.047","Retention Time":"5.493","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"621-37-4"},{"Metabolite":"Diaminopimelic acid","Mass":"190.0961","Retention Time":"1.411","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"583-93-7"},{"Metabolite":"Uridine","Mass":"244.0695","Retention Time":"2.2819998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"58-96-8"},{"Metabolite":"Caffeine","Mass":"194.0804","Retention Time":"6.0569997","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"58-08-2"},{"Metabolite":"O-Phosphorylethanolamine","Mass":"141.0197","Retention Time":"1.2760003","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"1071-23-4"},{"Metabolite":"L-Norvaline","Mass":"117.0794","Retention Time":"1.6720004","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"6600-40-4"},{"Metabolite":"L-Leucine","Mass":"131.0951","Retention Time":"2.664","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"61-90-5"},{"Metabolite":"Trigonelline","Mass":"137.0476","Retention Time":"1.4500002","Ion Species":"[M+H]+","CAS Number":"535-83-1"},{"Metabolite":"Xylitol","Mass":"152.0686","Retention Time":"1.4109999","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"87-99-0"},{"Metabolite":"Glutamyl-Tyrosine","Mass":"310.1162","Retention Time":"4.007","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"9046-27-9"},{"Metabolite":"L-Arginine","Mass":"174.1117","Retention Time":"1.2590001","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"74-79-3"},{"Metabolite":"5?-Deoxy-5?-(methylthio)adenosine","Mass":"297.0892","Retention Time":"5.316001","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"2457-80-9"},{"Metabolite":"2-Deoxyglucose","Mass":"164.0686","Retention Time":"1.4799998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"154-17-6"},{"Metabolite":"L-Tyrosine","Mass":"181.0743","Retention Time":"2.229","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"60-18-4"},{"Metabolite":"Deoxyguanosine","Mass":"267.097","Retention Time":"3.1959996","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"961-07-9"},{"Metabolite":"N-acetylaspartate","Mass":"175.0484","Retention Time":"1.8940005","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"997-55-7"},{"Metabolite":"3-Methylglutaric acid","Mass":"146.058","Retention Time":"4.713","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"626-51-7"},{"Metabolite":"N-Acetylneuraminic Acid","Mass":"309.1058","Retention Time":"1.4610002","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"131-48-6"},{"Metabolite":"Octopamine (p-Hydroxyphenylethanolamine)","Mass":"153.08","Retention Time":"1.2900002","Ion Species":"[M+K]+ [M+Na]+","CAS Number":"104-14-3"},{"Metabolite":"S-Adenosylhomocysteine","Mass":"384.1207","Retention Time":"2.5130002","Ion Species":"[M+H]+","CAS Number":"979-92-0"},{"Metabolite":"Riboflavin (Vitamin B2)","Mass":"376.1375","Retention Time":"6.5299993","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"83-88-5"},{"Metabolite":"4-Hydroxyphenylpyruvic acid","Mass":"180.0426","Retention Time":"3.295","Ion Species":"[M+Na]+","CAS Number":"156-39-8"},{"Metabolite":"2-Methylglutaric acid","Mass":"146.058","Retention Time":"4.713","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"617-62-9"},{"Metabolite":"Adenine","Mass":"135.0552","Retention Time":"1.7239997","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"73-24-5"},{"Metabolite":"Pyroglutamic acid","Mass":"129.0433","Retention Time":"2.111","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"98-79-3"},{"Metabolite":"Uracil","Mass":"112.0276","Retention Time":"1.8589997","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"66-22-8"},{"Metabolite":"Carnitine","Mass":"161.1059","Retention Time":"1.3059999","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"541-15-1"},{"Metabolite":"L-Valine","Mass":"117.0794","Retention Time":"1.6720004","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"72-18-4"},{"Metabolite":"1-Aminocyclopropane-1-carboxylic acid","Mass":"101.0482","Retention Time":"1.325","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"22059-21-8"},{"Metabolite":"10-hydroxy capric acid","Mass":"188.1415","Retention Time":"9.354998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"1679-53-4"},{"Metabolite":"Erythritol","Mass":"122.0603","Retention Time":"1.4069997","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"149-32-6"},{"Metabolite":"Chenodeoxycholic Acid","Mass":"392.3002","Retention Time":"12.431","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"474-25-9"},{"Metabolite":"DL-3-amino-isobutanoic acid","Mass":"103.0636","Retention Time":"1.279","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"144-90-1"},{"Metabolite":"N-ALPHA-ACETYL-L-ASPARAGINE","Mass":"174.0642","Retention Time":"1.6289998","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"4033-40-3"},{"Metabolite":"Monomethyl glutaric acid","Mass":"146.0584","Retention Time":"5.4770007","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"1501-27-5"},{"Metabolite":"Succinylacetone HT-1","Mass":"158.0578","Retention Time":"4.225","Ion Species":"[M+H]+ [M+K]+ [M+Na]+","CAS Number":"51568-18-4"},{"Metabolite":"Glyceraldehyde","Mass":"90.0318","Retention Time":"1.422","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"56-82-6"},{"Metabolite":"Uridine monophosphate (UMP)","Mass":"324.0353","Retention Time":"1.7229999","Ion Species":"[M+H]+ [M+Na]+","CAS Number":"58-97-9"},{"Metabolite":"Dihydrouracil","Mass":"114.043","Retention Time":"1.483","Ion Species":"[M+H]+","CAS Number":"504-07-4"},{"Metabolite":"5-Methylcytosine","Mass":"125.0588","Retention Time":"1.616","Ion Species":"[M+H]+","CAS Number":"554-01-8"},{"Metabolite":"Pyridoxal Phosphate","Mass":"247.0245","Retention Time":"2.722","Ion Species":"[M+H]+","CAS Number":"54-47-7"}]
}

}