{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002206","ANALYSIS_ID":"AN003609","VERSION":"1","CREATED_ON":"June 30, 2022, 10:34 am"},

"PROJECT":{"PROJECT_TITLE":"Lipolysis-derived Lipids Determine Autophagy Initiation during Fasting","PROJECT_SUMMARY":"For survival, autophagy is a crucial intracellular self-degradation process to provide energy sources, helping adapt to nutrient deprivation. Although nutrient availability is a key determinant of autophagy initiation, it remains elusive underlying mechanism(s) of perceiving nutritional scarcity by which cells timely turn on autophagy as the last self-destructive process for energy supply. Here, we showed that PKA-dependent lipolysis can block the initiation of futile autophagy during short-term nutritional deprivation by repressing AMPK. Using Raman microscopy imaging and metabolomics, we found that autophagy occurred by reduction in available free fatty acids (FFAs) for energy sources. By modulating genes involved in lipolysis and fatty acid oxidation, we found that the use of lipolysis-derived FFAs precedes autophagy initiation. The dysregulated autophagy suppression during short-term fasting decreased motility and lifespan extension of worms. Taken together, these data suggest that PKA is a pivotal factor to orchestrate sophisticated catabolic pathways, preferring the use of PKA-mediated lipolytic products to repress futile autophagic degradation during short-term fasting through AMPK inhibition.","INSTITUTE":"Seoul National University","LAST_NAME":"Ji","FIRST_NAME":"Yul","ADDRESS":"San 56-1, Sillim-Dong, Kwanak-Gu, Seoul, Seoul, 08826, Korea, South","EMAIL":"withyul@snu.ac.kr","PHONE":"01025076912"},

"STUDY":{"STUDY_TITLE":"Lipolysis-derived Lipids Determine Autophagy Initiation during Fasting","STUDY_SUMMARY":"For survival, autophagy is a crucial intracellular self-degradation process to provide energy sources, helping adapt to nutrient deprivation. Although nutrient availability is a key determinant of autophagy initiation, it remains elusive underlying mechanism(s) of perceiving nutritional scarcity by which cells timely turn on autophagy as the last self-destructive process for energy supply. Here, we showed that PKA-dependent lipolysis can block the initiation of futile autophagy during short-term nutritional deprivation by repressing AMPK. Using Raman microscopy imaging and metabolomics, we found that autophagy occurred by reduction in available free fatty acids (FFAs) for energy sources. By modulating genes involved in lipolysis and fatty acid oxidation, we found that the use of lipolysis-derived FFAs precedes autophagy initiation. The dysregulated autophagy suppression during short-term fasting decreased motility and lifespan extension of worms. Taken together, these data suggest that PKA is a pivotal factor to orchestrate sophisticated catabolic pathways, preferring the use of PKA-mediated lipolytic products to repress futile autophagic degradation during short-term fasting through AMPK inhibition.","INSTITUTE":"Seoul National University","LAST_NAME":"Ji","FIRST_NAME":"Yul","ADDRESS":"San 56-1, Sillim-Dong, Kwanak-Gu, Seoul, Seoul, 08826, Korea, South","EMAIL":"withyul@snu.ac.kr","PHONE":"01025076912"},

"SUBJECT":{"SUBJECT_TYPE":"Invertebrate","SUBJECT_SPECIES":"Caenorhabditis elegans","TAXONOMY_ID":"6239"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"Fed1",
"Factors":{"experimental factor":"ad libitum"}
},
{
"Subject ID":"-",
"Sample ID":"Fed2",
"Factors":{"experimental factor":"ad libitum"}
},
{
"Subject ID":"-",
"Sample ID":"Fed3",
"Factors":{"experimental factor":"ad libitum"}
},
{
"Subject ID":"-",
"Sample ID":"Fast1-1",
"Factors":{"experimental factor":"Fasted 4 hours"}
},
{
"Subject ID":"-",
"Sample ID":"Fast1-2",
"Factors":{"experimental factor":"Fasted 4 hours"}
},
{
"Subject ID":"-",
"Sample ID":"Fast1-3",
"Factors":{"experimental factor":"Fasted 4 hours"}
},
{
"Subject ID":"-",
"Sample ID":"Fast2-1",
"Factors":{"experimental factor":"Fasted 8 hours"}
},
{
"Subject ID":"-",
"Sample ID":"Fast2-2",
"Factors":{"experimental factor":"Fasted 8 hours"}
},
{
"Subject ID":"-",
"Sample ID":"Fast2-3",
"Factors":{"experimental factor":"Fasted 8 hours"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"C. elegans were collected after dietary restricted conditions.","SAMPLE_TYPE":"Worms"},

"TREATMENT":{"TREATMENT_SUMMARY":"C. elegans were experienced restricted conditions."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"1. Sample Preparation for CE-TOFMS analysis The samples were mixed with 50% acetonitrile in water (v/v) containing internal standards (20 μM) as shown in Table 1 and homogenized by a homogenizer (1,500 rpm, 120 sec × 2 times), then, the same amount of 50% acetonitrile in water (v/v) were added.. The supernatant (400 μL) was then filtrated through 5-kDa cut-off filter(ULTRAFREE-MC-PLHCC, Human Metabolome Technologies, Yamagata, Japan) to remove macromolecules. The filtrate was centrifugally concentrated and resuspended in 25 μL of ultrapure water immediately before the measurement. 2. Sample Preparation for LC-TOFMS analysis The samples were mixed with 500 μL of 1% formic acid in acetonitrile (v/v) containing internal standards (10 μM), homogenized by a homogenizer (1,500 rpm, 120 sec × 2 times). The mixture was yet again homogenized after adding 167 μL of Milli-Q water and then centrifuged (2,300 x g, 4℃, 5min). After the supernatant was collected, 500 μL of 1% formic acid in acetonitrile (v/v) and 167 μL of MilliQ-water were added to the precipitation. The homogenization and centrifugation was performed as described previously, and the supernatant was mixed with previously collected one. The mixed supernatant was filtrated through 3-kDa cut-off filter (NANOCEP 3K OMEGA, PALL Corporation, Michigan, USA) to remove proteins and far filtrated through column (Hybrid SPE phospholipid 55261-U, Supelco, Bellefonte,PA, USA) to remove phospholipids. The filtrate was desiccated and resuspended in 200 μL of 50% isopropanol in Milli-Q water (v/v) immediately before the measurement."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"Liquid chromatography time-of-flight mass spectometry","INSTRUMENT_NAME":"Agilent 1200 RR Series II","COLUMN_NAME":"ODS column"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent CE-TOFMS","INSTRUMENT_TYPE":"LC/MSD","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"Peaks detected in CE-TOFMS and LC-TOFMS analysis were extracted using automatic integration software (MasterHands ver. 2.17.1.11 developed at Keio University) in order to obtain peak information including m/z, migration time (MT) in CE, retention time (RT) in LC, and peak area. The peak area was then converted to relative peak area by the following equation. The peak detection limit was determined based on signal-noise ratio; S/N = 3."},

"MS_METABOLITE_DATA":{
"Units":"relative area",

"Data":[{"Metabolite":"1,2-Dipalmitoyl-glycero-3-phosphoethanolamine","Fed1":"5.3E-05","Fed2":"1.4E-04","Fed3":"7.9E-05","Fast1-1":"1.8E-04","Fast1-2":"1.1E-04","Fast1-3":"1.1E-04","Fast2-1":"1.8E-04","Fast2-2":"2.0E-04","Fast2-3":"1.4E-04"},{"Metabolite":"1-Methyladenosine","Fed1":"1.3E-05","Fed2":"1.5E-05","Fed3":"1.4E-05","Fast1-1":"3.5E-05","Fast1-2":"5.6E-05","Fast1-3":"3.6E-05","Fast2-1":"7.3E-05","Fast2-2":"5.5E-05","Fast2-3":"4.8E-05"},{"Metabolite":"1-Pyrroline 5-carboxylic acid","Fed1":"4.5E-05","Fed2":"4.9E-05","Fed3":"4.6E-05","Fast1-1":"N.D.","Fast1-2":"3.3E-05","Fast1-3":"N.D.","Fast2-1":"N.D.","Fast2-2":"N.D.","Fast2-3":"N.D."},{"Metabolite":"2'-Deoxyguanosine","Fed1":"2.2E-04","Fed2":"2.5E-04","Fed3":"2.7E-04","Fast1-1":"1.3E-04","Fast1-2":"1.4E-04","Fast1-3":"1.1E-04","Fast2-1":"1.1E-04","Fast2-2":"1.1E-04","Fast2-3":"1.0E-04"},{"Metabolite":"2,6-Diaminopimelic acid","Fed1":"N.D.","Fed2":"2.9E-05","Fed3":"2.8E-05","Fast1-1":"N.D.","Fast1-2":"N.D.","Fast1-3":"3.1E-05","Fast2-1":"N.D.","Fast2-2":"3.1E-05","Fast2-3":"N.D."},{"Metabolite":"2-Amino-2-(hydroxymethyl)-1,3-propanediol","Fed1":"N.D.","Fed2":"3.3E-05","Fed3":"N.D.","Fast1-1":"N.D.","Fast1-2":"N.D.","Fast1-3":"N.D.","Fast2-1":"N.D.","Fast2-2":"N.D.","Fast2-3":"N.D."},{"Metabolite":"2-Arachidonoylglycerol-1","Fed1":"2.5E-04","Fed2":"3.1E-04","Fed3":"2.1E-04","Fast1-1":"2.9E-04","Fast1-2":"2.8E-04","Fast1-3":"3.2E-04","Fast2-1":"2.9E-04","Fast2-2":"3.5E-04","Fast2-3":"4.9E-04"},{"Metabolite":"2-Arachidonoylglycerol-2","Fed1":"7.7E-04","Fed2":"9.7E-04","Fed3":"1.2E-03","Fast1-1":"1.5E-03","Fast1-2":"1.2E-03","Fast1-3":"1.5E-03","Fast2-1":"5.1E-04","Fast2-2":"6.0E-04","Fast2-3":"6.7E-04"},{"Metabolite":"2-Arachidonoylglycerol-3","Fed1":"1.5E-03","Fed2":"2.7E-03","Fed3":"2.6E-03","Fast1-1":"4.1E-03","Fast1-2":"3.1E-03","Fast1-3":"3.4E-03","Fast2-1":"9.8E-04","Fast2-2":"1.1E-03","Fast2-3":"1.4E-03"},{"Metabolite":"2-Deoxyglucose 6-phosphate","Fed1":"5.1E-05","Fed2":"5.2E-05","Fed3":"5.4E-05","Fast1-1":"N.D.","Fast1-2":"N.D.","Fast1-3":"N.D.","Fast2-1":"N.D.","Fast2-2":"N.D.","Fast2-3":"N.D."},{"Metabolite":"2-Hydroxy-4-methylvaleric acid","Fed1":"3.3E-04","Fed2":"4.4E-04","Fed3":"4.1E-04","Fast1-1":"N.D.","Fast1-2":"N.D.","Fast1-3":"N.D.","Fast2-1":"N.D.","Fast2-2":"N.D.","Fast2-3":"N.D."},{"Metabolite":"2-Hydroxybutyric acid","Fed1":"6.7E-04","Fed2":"9.6E-04","Fed3":"8.5E-04","Fast1-1":"N.D.","Fast1-2":"N.D.","Fast1-3":"N.D.","Fast2-1":"N.D.","Fast2-2":"N.D.","Fast2-3":"N.D."},{"Metabolite":"2-Hydroxyglutaric acid","Fed1":"3.4E-03","Fed2":"4.5E-03","Fed3":"4.7E-03","Fast1-1":"3.1E-03","Fast1-2":"2.7E-03","Fast1-3":"3.0E-03","Fast2-1":"1.0E-03","Fast2-2":"1.1E-03","Fast2-3":"8.8E-04"},{"Metabolite":"2-Hydroxytetradecanoic acid","Fed1":"2.7E-05","Fed2":"3.4E-04","Fed3":"2.8E-04","Fast1-1":"4.4E-04","Fast1-2":"6.7E-05","Fast1-3":"5.2E-04","Fast2-1":"5.0E-05","Fast2-2":"2.0E-04","Fast2-3":"2.8E-04"},{"Metabolite":"2-Oxoadipic acid","Fed1":"2.4E-04","Fed2":"2.0E-04","Fed3":"2.0E-04","Fast1-1":"N.D.","Fast1-2":"1.5E-04","Fast1-3":"N.D.","Fast2-1":"N.D.","Fast2-2":"N.D.","Fast2-3":"N.D."},{"Metabolite":"2-Oxoglutaric acid","Fed1":"5.1E-04","Fed2":"6.0E-04","Fed3":"5.3E-04","Fast1-1":"4.9E-04","Fast1-2":"5.4E-04","Fast1-3":"5.8E-04","Fast2-1":"N.D.","Fast2-2":"N.D.","Fast2-3":"N.D."},{"Metabolite":"2-Oxoisovaleric acid","Fed1":"8.6E-05","Fed2":"9.7E-05","Fed3":"N.D.","Fast1-1":"N.D.","Fast1-2":"N.D.","Fast1-3":"N.D.","Fast2-1":"N.D.","Fast2-2":"N.D.","Fast2-3":"N.D."},{"Metabolite":"2-Phosphoglyceric acid","Fed1":"3.1E-04","Fed2":"3.0E-04","Fed3":"4.1E-04","Fast1-1":"3.8E-04","Fast1-2":"3.2E-04","Fast1-3":"4.0E-04","Fast2-1":"2.9E-04","Fast2-2":"2.8E-04","Fast2-3":"2.3E-04"},{"Metabolite":"3',5'-ADP","Fed1":"N.D.","Fed2":"5.8E-05","Fed3":"5.0E-05","Fast1-1":"7.8E-05","Fast1-2":"7.5E-05","Fast1-3":"7.2E-05","Fast2-1":"6.6E-05","Fast2-2":"6.0E-05","Fast2-3":"N.D."},{"Metabolite":"3-Amino-2-piperidone","Fed1":"N.D.","Fed2":"N.D.","Fed3":"N.D.","Fast1-1":"N.D.","Fast1-2":"N.D.","Fast1-3":"N.D.","Fast2-1":"1.4E-04","Fast2-2":"1.2E-04","Fast2-3":"1.4E-04"},{"Metabolite":"3-Aminoisobutyric acid","Fed1":"1.5E-02","Fed2":"2.1E-02","Fed3":"1.7E-02","Fast1-1":"6.2E-04","Fast1-2":"5.9E-04","Fast1-3":"4.6E-04","Fast2-1":"8.5E-04","Fast2-2":"8.6E-04","Fast2-3":"6.9E-04"},{"Metabolite":"3-Hydroxybutyric acid","Fed1":"2.1E-03","Fed2":"2.9E-03","Fed3":"2.7E-03","Fast1-1":"3.6E-04","Fast1-2":"3.2E-04","Fast1-3":"3.4E-04","Fast2-1":"2.1E-04","Fast2-2":"1.8E-04","Fast2-3":"1.9E-04"},{"Metabolite":"3-Hydroxypropionic acid","Fed1":"1.1E-03","Fed2":"1.5E-03","Fed3":"1.3E-03","Fast1-1":"3.3E-04","Fast1-2":"4.2E-04","Fast1-3":"3.7E-04","Fast2-1":"1.8E-04","Fast2-2":"2.1E-04","Fast2-3":"1.5E-04"},{"Metabolite":"3-Methyladenine","Fed1":"N.D.","Fed2":"1.8E-05","Fed3":"N.D.","Fast1-1":"2.4E-05","Fast1-2":"4.4E-05","Fast1-3":"4.2E-05","Fast2-1":"1.4E-04","Fast2-2":"1.2E-04","Fast2-3":"1.1E-04"},{"Metabolite":"3-Phenylpropionic acid","Fed1":"5.2E-05","Fed2":"7.9E-05","Fed3":"6.6E-05","Fast1-1":"5.4E-05","Fast1-2":"7.4E-05","Fast1-3":"8.6E-05","Fast2-1":"8.3E-05","Fast2-2":"8.6E-05","Fast2-3":"8.2E-05"},{"Metabolite":"3-Phosphoglyceric acid","Fed1":"2.3E-03","Fed2":"2.9E-03","Fed3":"3.0E-03","Fast1-1":"3.2E-03","Fast1-2":"2.8E-03","Fast1-3":"3.2E-03","Fast2-1":"2.7E-03","Fast2-2":"2.4E-03","Fast2-3":"2.1E-03"},{"Metabolite":"3-Ureidopropionic acid","Fed1":"4.9E-05","Fed2":"5.2E-05","Fed3":"5.6E-05","Fast1-1":"N.D.","Fast1-2":"N.D.","Fast1-3":"2.3E-05","Fast2-1":"N.D.","Fast2-2":"N.D.","Fast2-3":"N.D."},{"Metabolite":"4-Guanidinobutyric acid","Fed1":"4.4E-05","Fed2":"5.9E-05","Fed3":"3.5E-05","Fast1-1":"8.6E-05","Fast1-2":"N.D.","Fast1-3":"8.1E-05","Fast2-1":"1.9E-04","Fast2-2":"2.2E-04","Fast2-3":"2.0E-04"},{"Metabolite":"5-Hydroxylysine","Fed1":"2.5E-04","Fed2":"3.7E-04","Fed3":"3.1E-04","Fast1-1":"6.4E-05","Fast1-2":"6.4E-05","Fast1-3":"6.0E-05","Fast2-1":"7.2E-04","Fast2-2":"7.3E-04","Fast2-3":"7.4E-04"},{"Metabolite":"5-Hydroxytryptophan","Fed1":"5.7E-05","Fed2":"7.9E-05","Fed3":"5.8E-05","Fast1-1":"1.4E-04","Fast1-2":"1.2E-04","Fast1-3":"1.3E-04","Fast2-1":"1.9E-04","Fast2-2":"1.8E-04","Fast2-3":"1.2E-04"},{"Metabolite":"5-Oxoproline","Fed1":"9.2E-04","Fed2":"1.1E-03","Fed3":"1.0E-03","Fast1-1":"1.2E-03","Fast1-2":"1.3E-03","Fast1-3":"1.2E-03","Fast2-1":"2.6E-03","Fast2-2":"2.3E-03","Fast2-3":"2.3E-03"},{"Metabolite":"6-Phosphogluconic acid","Fed1":"1.5E-04","Fed2":"2.6E-04","Fed3":"1.9E-04","Fast1-1":"1.3E-04","Fast1-2":"1.3E-04","Fast1-3":"1.4E-04","Fast2-1":"1.0E-04","Fast2-2":"9.4E-05","Fast2-3":"9.6E-05"},{"Metabolite":"7,8-Dihydrobiopterin","Fed1":"1.5E-05","Fed2":"1.7E-05","Fed3":"1.5E-05","Fast1-1":"3.5E-05","Fast1-2":"2.4E-05","Fast1-3":"4.1E-05","Fast2-1":"3.0E-05","Fast2-2":"3.1E-05","Fast2-3":"3.0E-05"},{"Metabolite":"7-Methylguanine","Fed1":"N.D.","Fed2":"2.5E-05","Fed3":"2.2E-05","Fast1-1":"N.D.","Fast1-2":"2.5E-05","Fast1-3":"2.0E-05","Fast2-1":"3.3E-04","Fast2-2":"3.2E-04","Fast2-3":"2.6E-04"},{"Metabolite":"Abietic acid-1","Fed1":"3.8E-04","Fed2":"6.8E-04","Fed3":"3.3E-04","Fast1-1":"5.3E-04","Fast1-2":"6.8E-04","Fast1-3":"4.8E-04","Fast2-1":"7.2E-04","Fast2-2":"7.5E-04","Fast2-3":"5.5E-04"},{"Metabolite":"Abietic acid-2","Fed1":"1.6E-04","Fed2":"2.0E-04","Fed3":"2.3E-04","Fast1-1":"3.7E-04","Fast1-2":"3.5E-04","Fast1-3":"3.5E-04","Fast2-1":"N.D.","Fast2-2":"N.D.","Fast2-3":"3.0E-04"},{"Metabolite":"Abietic acid-3","Fed1":"1.1E-04","Fed2":"8.5E-05","Fed3":"N.D.","Fast1-1":"N.D.","Fast1-2":"N.D.","Fast1-3":"1.7E-04","Fast2-1":"N.D.","Fast2-2":"1.3E-04","Fast2-3":"1.4E-04"},{"Metabolite":"Acetyl 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acid","Fed1":"1.3E-04","Fed2":"1.7E-04","Fed3":"1.5E-04","Fast1-1":"1.2E-04","Fast1-2":"1.1E-04","Fast1-3":"1.3E-04","Fast2-1":"1.1E-04","Fast2-2":"9.5E-05","Fast2-3":"9.6E-05"},{"Metabolite":"UMP","Fed1":"1.4E-03","Fed2":"2.1E-03","Fed3":"1.7E-03","Fast1-1":"2.0E-03","Fast1-2":"2.1E-03","Fast1-3":"2.2E-03","Fast2-1":"2.7E-03","Fast2-2":"2.2E-03","Fast2-3":"2.2E-03"},{"Metabolite":"Uracil","Fed1":"N.D.","Fed2":"2.2E-04","Fed3":"2.1E-04","Fast1-1":"2.1E-04","Fast1-2":"2.5E-04","Fast1-3":"2.8E-04","Fast2-1":"2.1E-04","Fast2-2":"2.1E-04","Fast2-3":"2.2E-04"},{"Metabolite":"Urea","Fed1":"2.1E-02","Fed2":"2.7E-02","Fed3":"2.4E-02","Fast1-1":"1.3E-02","Fast1-2":"1.2E-02","Fast1-3":"1.1E-02","Fast2-1":"7.7E-03","Fast2-2":"9.2E-03","Fast2-3":"6.2E-03"},{"Metabolite":"Uric acid","Fed1":"2.6E-03","Fed2":"3.5E-03","Fed3":"3.6E-03","Fast1-1":"1.4E-03","Fast1-2":"1.4E-03","Fast1-3":"1.4E-03","Fast2-1":"5.9E-03","Fast2-2":"4.8E-03","Fast2-3":"4.4E-03"},{"Metabolite":"Uridine","Fed1":"3.8E-04","Fed2":"3.8E-04","Fed3":"5.0E-04","Fast1-1":"7.9E-04","Fast1-2":"9.3E-04","Fast1-3":"1.0E-03","Fast2-1":"8.0E-04","Fast2-2":"7.3E-04","Fast2-3":"6.7E-04"},{"Metabolite":"Urocanic acid","Fed1":"8.2E-05","Fed2":"1.0E-04","Fed3":"6.0E-05","Fast1-1":"3.6E-05","Fast1-2":"4.7E-05","Fast1-3":"3.7E-05","Fast2-1":"2.7E-05","Fast2-2":"3.3E-05","Fast2-3":"3.0E-05"},{"Metabolite":"UTP","Fed1":"5.3E-04","Fed2":"5.0E-04","Fed3":"6.6E-04","Fast1-1":"2.2E-04","Fast1-2":"1.8E-04","Fast1-3":"1.5E-04","Fast2-1":"1.1E-04","Fast2-2":"1.8E-04","Fast2-3":"1.5E-04"},{"Metabolite":"Val","Fed1":"4.7E-02","Fed2":"5.9E-02","Fed3":"5.2E-02","Fast1-1":"1.6E-02","Fast1-2":"1.6E-02","Fast1-3":"1.6E-02","Fast2-1":"2.2E-02","Fast2-2":"2.2E-02","Fast2-3":"2.1E-02"},{"Metabolite":"Xanthine","Fed1":"5.5E-04","Fed2":"7.5E-04","Fed3":"6.2E-04","Fast1-1":"6.4E-04","Fast1-2":"7.3E-04","Fast1-3":"8.4E-04","Fast2-1":"2.7E-03","Fast2-2":"2.5E-03","Fast2-3":"2.4E-03"},{"Metabolite":"β-Ala","Fed1":"1.3E-02","Fed2":"1.7E-02","Fed3":"1.5E-02","Fast1-1":"5.2E-03","Fast1-2":"4.3E-03","Fast1-3":"5.2E-03","Fast2-1":"4.1E-03","Fast2-2":"3.7E-03","Fast2-3":"2.5E-03"},{"Metabolite":"β-Ala-Lys","Fed1":"1.4E-04","Fed2":"N.D.","Fed3":"1.7E-04","Fast1-1":"N.D.","Fast1-2":"1.9E-04","Fast1-3":"2.2E-04","Fast2-1":"1.6E-04","Fast2-2":"1.1E-04","Fast2-3":"1.3E-04"},{"Metabolite":"β-Hydroxyisovaleric acid","Fed1":"6.8E-05","Fed2":"7.5E-05","Fed3":"8.9E-05","Fast1-1":"4.4E-05","Fast1-2":"4.8E-05","Fast1-3":"5.7E-05","Fast2-1":"6.3E-05","Fast2-2":"5.6E-05","Fast2-3":"5.2E-05"},{"Metabolite":"γ-Butyrobetaine","Fed1":"1.7E-04","Fed2":"2.3E-04","Fed3":"1.6E-04","Fast1-1":"1.7E-04","Fast1-2":"1.8E-04","Fast1-3":"1.6E-04","Fast2-1":"3.0E-04","Fast2-2":"2.9E-04","Fast2-3":"2.9E-04"},{"Metabolite":"γ-Glu-Cys","Fed1":"2.1E-04","Fed2":"3.3E-04","Fed3":"2.8E-04","Fast1-1":"2.1E-04","Fast1-2":"1.8E-04","Fast1-3":"2.1E-04","Fast2-1":"1.5E-04","Fast2-2":"1.6E-04","Fast2-3":"1.3E-04"}],

"Metabolites":[{"Metabolite":"1,2-Dipalmitoyl-glycero-3-phosphoethanolamine","PubChem identifiers":"445468","quantitated m/z":"692.524"},{"Metabolite":"1-Methyladenosine","PubChem identifiers":"27476","quantitated m/z":"282.121"},{"Metabolite":"1-Pyrroline 5-carboxylic acid","PubChem identifiers":"440162","quantitated m/z":"114.055"},{"Metabolite":"2'-Deoxyguanosine","PubChem identifiers":"187790","quantitated m/z":"268.105"},{"Metabolite":"2,6-Diaminopimelic acid","PubChem identifiers":"439283","quantitated m/z":"191.103"},{"Metabolite":"2-Amino-2-(hydroxymethyl)-1,3-propanediol","PubChem identifiers":"6503","quantitated m/z":"122.081"},{"Metabolite":"2-Arachidonoylglycerol-1","PubChem identifiers":"5282280","quantitated m/z":"379.279"},{"Metabolite":"2-Arachidonoylglycerol-2","PubChem identifiers":"5282280","quantitated m/z":"379.289"},{"Metabolite":"2-Arachidonoylglycerol-3","PubChem identifiers":"5282280","quantitated m/z":"379.288"},{"Metabolite":"2-Deoxyglucose 6-phosphate","PubChem identifiers":"440992","quantitated m/z":"243.028"},{"Metabolite":"2-Hydroxy-4-methylvaleric acid","PubChem identifiers":"439960","quantitated m/z":"131.073"},{"Metabolite":"2-Hydroxybutyric acid","PubChem identifiers":"440864","quantitated m/z":"103.041"},{"Metabolite":"2-Hydroxyglutaric acid","PubChem identifiers":"43","quantitated m/z":"147.031"},{"Metabolite":"2-Hydroxytetradecanoic acid","PubChem identifiers":"656737","quantitated m/z":"243.200"},{"Metabolite":"2-Oxoadipic acid","PubChem identifiers":"71","quantitated m/z":"159.031"},{"Metabolite":"2-Oxoglutaric acid","PubChem identifiers":"51","quantitated m/z":"145.015"},{"Metabolite":"2-Oxoisovaleric acid","PubChem identifiers":"49","quantitated m/z":"115.042"},{"Metabolite":"2-Phosphoglyceric acid","PubChem identifiers":"439278","quantitated m/z":"184.987"},{"Metabolite":"3',5'-ADP","PubChem identifiers":"159296","quantitated m/z":"426.024"},{"Metabolite":"3-Amino-2-piperidone","PubChem identifiers":"5200225","quantitated m/z":"115.087"},{"Metabolite":"3-Aminoisobutyric acid","PubChem identifiers":"64956","quantitated m/z":"104.071"},{"Metabolite":"3-Hydroxybutyric acid","PubChem identifiers":"441","quantitated m/z":"103.041"},{"Metabolite":"3-Hydroxypropionic acid","PubChem identifiers":"68152","quantitated m/z":"89.026"},{"Metabolite":"3-Methyladenine","PubChem identifiers":"1673","quantitated m/z":"150.078"},{"Metabolite":"3-Phenylpropionic acid","PubChem identifiers":"107","quantitated m/z":"149.060"},{"Metabolite":"3-Phosphoglyceric acid","PubChem identifiers":"439183","quantitated m/z":"184.987"},{"Metabolite":"3-Ureidopropionic acid","PubChem identifiers":"111","quantitated m/z":"131.047"},{"Metabolite":"4-Guanidinobutyric acid","PubChem identifiers":"500","quantitated m/z":"146.094"},{"Metabolite":"5-Hydroxylysine","PubChem identifiers":"3032849","quantitated m/z":"163.109"},{"Metabolite":"5-Hydroxytryptophan","PubChem identifiers":"439280","quantitated m/z":"221.094"},{"Metabolite":"5-Oxoproline","PubChem identifiers":"7405","quantitated m/z":"128.036"},{"Metabolite":"6-Phosphogluconic acid","PubChem identifiers":"91493","quantitated m/z":"275.019"},{"Metabolite":"7,8-Dihydrobiopterin","PubChem identifiers":"119055","quantitated m/z":"240.109"},{"Metabolite":"7-Methylguanine","PubChem identifiers":"11361","quantitated m/z":"166.073"},{"Metabolite":"Abietic acid-1","PubChem identifiers":"10569","quantitated m/z":"303.239"},{"Metabolite":"Abietic acid-2","PubChem identifiers":"10569","quantitated m/z":"303.233"},{"Metabolite":"Abietic acid-3","PubChem identifiers":"10569","quantitated m/z":"303.231"},{"Metabolite":"Acetyl CoA_divalent","PubChem identifiers":"444493","quantitated m/z":"403.557"},{"Metabolite":"Acetylcholine","PubChem identifiers":"187","quantitated m/z":"146.118"},{"Metabolite":"Adenine","PubChem identifiers":"190","quantitated m/z":"136.063"},{"Metabolite":"Adenosine","PubChem identifiers":"60961","quantitated m/z":"268.106"},{"Metabolite":"ADMA","PubChem identifiers":"123831","quantitated m/z":"203.151"},{"Metabolite":"ADP","PubChem identifiers":"6022","quantitated m/z":"426.025"},{"Metabolite":"Agmatine","PubChem identifiers":"199","quantitated m/z":"131.129"},{"Metabolite":"Ala","PubChem identifiers":"602","quantitated m/z":"91.058"},{"Metabolite":"allo-Threonine","PubChem identifiers":"99289","quantitated m/z":"120.065"},{"Metabolite":"Aminoacetone","PubChem identifiers":"215","quantitated m/z":"74.060"},{"Metabolite":"AMP","PubChem identifiers":"6083","quantitated m/z":"346.058"},{"Metabolite":"Aniline","PubChem identifiers":"6115","quantitated m/z":"92.051"},{"Metabolite":"Anthranilic acid","PubChem identifiers":"227","quantitated m/z":"138.056"},{"Metabolite":"Arachidic acid","PubChem identifiers":"10467","quantitated m/z":"311.298"},{"Metabolite":"Arachidonic acid","PubChem identifiers":"444899","quantitated m/z":"303.236"},{"Metabolite":"Arg","PubChem identifiers":"6322","quantitated m/z":"175.120"},{"Metabolite":"Ascorbate 2-glucoside","PubChem identifiers":"54693473","quantitated m/z":"337.079"},{"Metabolite":"Ascorbic acid","PubChem identifiers":"54670067","quantitated m/z":"175.026"},{"Metabolite":"Asn","PubChem identifiers":"236","quantitated m/z":"133.061"},{"Metabolite":"Asp","PubChem identifiers":"424","quantitated m/z":"134.045"},{"Metabolite":"ATP","PubChem identifiers":"5957","quantitated m/z":"505.991"},{"Metabolite":"Azelaic acid","PubChem identifiers":"2266","quantitated m/z":"187.099"},{"Metabolite":"Behenic acid","PubChem identifiers":"8215","quantitated m/z":"339.330"},{"Metabolite":"Benzoic acid","PubChem identifiers":"243","quantitated m/z":"121.031"},{"Metabolite":"Betaine","PubChem identifiers":"247","quantitated m/z":"118.087"},{"Metabolite":"Biotin","PubChem identifiers":"171548","quantitated m/z":"245.098"},{"Metabolite":"Butyrylcarnitine","PubChem identifiers":"439829","quantitated m/z":"232.155"},{"Metabolite":"Cadaverine","PubChem identifiers":"273","quantitated m/z":"103.123"},{"Metabolite":"Carboxymethyllysine","PubChem identifiers":"123800","quantitated m/z":"205.119"},{"Metabolite":"Carnitine","PubChem identifiers":"85","quantitated m/z":"162.113"},{"Metabolite":"CDP","PubChem identifiers":"6132","quantitated m/z":"402.013"},{"Metabolite":"CDP-choline","PubChem identifiers":"13804","quantitated m/z":"487.102"},{"Metabolite":"Cholesterol sulfate","PubChem identifiers":"65076","quantitated m/z":"465.307"},{"Metabolite":"Cholic acid","PubChem identifiers":"221493","quantitated m/z":"407.283"},{"Metabolite":"Choline","PubChem identifiers":"305","quantitated m/z":"104.108"},{"Metabolite":"cis-11,14-Eicosadienoic acid","PubChem identifiers":"6439848","quantitated m/z":"307.267"},{"Metabolite":"cis-11-Eicosenoic acid","PubChem identifiers":"5282768","quantitated m/z":"309.283"},{"Metabolite":"cis-4-Hydroxyproline","PubChem identifiers":"440014","quantitated m/z":"132.066"},{"Metabolite":"cis-5,8,11,14,17-Eicosapentaenoic acid","PubChem identifiers":"446284","quantitated m/z":"301.221"},{"Metabolite":"cis-8,11,14-Eicosatrienoic acid","PubChem identifiers":"5280581","quantitated m/z":"305.252"},{"Metabolite":"cis-Aconitic acid","PubChem identifiers":"643757","quantitated m/z":"173.010"},{"Metabolite":"Citraconic acid","PubChem identifiers":"643798","quantitated m/z":"129.020"},{"Metabolite":"Citric acid","PubChem identifiers":"311","quantitated m/z":"191.021"},{"Metabolite":"Citrulline","PubChem identifiers":"9750","quantitated m/z":"176.104"},{"Metabolite":"CMP","PubChem identifiers":"6131","quantitated m/z":"322.047"},{"Metabolite":"CoA_divalent","PubChem identifiers":"87642","quantitated m/z":"382.553"},{"Metabolite":"Coenzyme Q10","PubChem identifiers":"5281915","quantitated m/z":"863.690"},{"Metabolite":"Creatine","PubChem identifiers":"586","quantitated m/z":"132.077"},{"Metabolite":"Creatinine","PubChem identifiers":"588","quantitated m/z":"114.066"},{"Metabolite":"CTP","PubChem identifiers":"6176","quantitated m/z":"481.979"},{"Metabolite":"Cys","PubChem identifiers":"594","quantitated m/z":"122.028"},{"Metabolite":"Cys-Gly","PubChem identifiers":"439498","quantitated m/z":"179.047"},{"Metabolite":"Cystathionine","PubChem identifiers":"834","quantitated m/z":"223.076"},{"Metabolite":"Cysteine glutathione disulfide","PubChem identifiers":"10455148","quantitated m/z":"427.097"},{"Metabolite":"Cysteinesulfinic acid","PubChem identifiers":"1549098","quantitated m/z":"152.003"},{"Metabolite":"Cystine","PubChem identifiers":"595","quantitated m/z":"241.032"},{"Metabolite":"Cytidine","PubChem identifiers":"6175","quantitated m/z":"244.101"},{"Metabolite":"Decanoic acid","PubChem identifiers":"2969","quantitated m/z":"171.140"},{"Metabolite":"Deoxycholic acid","PubChem identifiers":"222528","quantitated m/z":"391.289"},{"Metabolite":"Diethanolamine","PubChem identifiers":"8113","quantitated m/z":"106.087"},{"Metabolite":"Dihydroxyacetone phosphate","PubChem identifiers":"668","quantitated m/z":"168.992"},{"Metabolite":"Diosgenin","PubChem identifiers":"99474","quantitated m/z":"415.328"},{"Metabolite":"dTMP","PubChem identifiers":"9700","quantitated m/z":"321.053"},{"Metabolite":"Dyphylline","PubChem identifiers":"3182","quantitated m/z":"255.109"},{"Metabolite":"Erucic acid","PubChem identifiers":"5281116","quantitated m/z":"337.315"},{"Metabolite":"Estriol","PubChem identifiers":"5756","quantitated m/z":"306.208"},{"Metabolite":"Ethanolamine","PubChem identifiers":"700","quantitated m/z":"62.061"},{"Metabolite":"Ethanolamine phosphate","PubChem identifiers":"1015","quantitated m/z":"140.013"},{"Metabolite":"FAD_divalent","PubChem identifiers":"643975","quantitated m/z":"391.574"},{"Metabolite":"FMN","PubChem identifiers":"643976","quantitated m/z":"455.099"},{"Metabolite":"Formiminoglutamic acid","PubChem identifiers":"439233","quantitated m/z":"173.058"},{"Metabolite":"Fructose 1,6-diphosphate","PubChem identifiers":"172313","quantitated m/z":"338.991"},{"Metabolite":"Fructose 6-phosphate","PubChem identifiers":"603","quantitated m/z":"259.024"},{"Metabolite":"Fumaric acid","PubChem identifiers":"444972","quantitated m/z":"115.005"},{"Metabolite":"GABA","PubChem identifiers":"119","quantitated m/z":"104.071"},{"Metabolite":"GDP","PubChem identifiers":"8977","quantitated m/z":"442.020"},{"Metabolite":"Gln","PubChem identifiers":"738","quantitated m/z":"147.077"},{"Metabolite":"Glu","PubChem identifiers":"611","quantitated m/z":"148.062"},{"Metabolite":"Gluconolactone","PubChem identifiers":"7027","quantitated m/z":"179.055"},{"Metabolite":"Glucosamine 6-sulfuric acid","PubChem identifiers":"72361","quantitated m/z":"260.045"},{"Metabolite":"Glucose 1-phosphate","PubChem identifiers":"65533","quantitated m/z":"259.024"},{"Metabolite":"Glucose 6-phosphate","PubChem identifiers":"5958","quantitated m/z":"259.024"},{"Metabolite":"Glutaric acid","PubChem identifiers":"743","quantitated m/z":"131.036"},{"Metabolite":"Glutathione (GSH)","PubChem identifiers":"124886","quantitated m/z":"308.092"},{"Metabolite":"Glutathione (GSSG)_divalent","PubChem identifiers":"65359","quantitated m/z":"307.085"},{"Metabolite":"Gly","PubChem identifiers":"750","quantitated m/z":"76.040"},{"Metabolite":"Gly-Asp","PubChem identifiers":"97363","quantitated m/z":"191.068"},{"Metabolite":"Gly-Gly","PubChem identifiers":"11163","quantitated m/z":"133.061"},{"Metabolite":"Glyceric acid","PubChem identifiers":"439194","quantitated m/z":"105.020"},{"Metabolite":"Glycerol","PubChem identifiers":"753","quantitated m/z":"93.055"},{"Metabolite":"Glycerol 3-phosphate","PubChem identifiers":"439162","quantitated m/z":"171.008"},{"Metabolite":"Glycerophosphocholine","PubChem identifiers":"439285","quantitated m/z":"258.111"},{"Metabolite":"Glycochenodeoxycholic acid","PubChem identifiers":"12544","quantitated m/z":"448.309"},{"Metabolite":"Glycocholic acid","PubChem identifiers":"10140","quantitated m/z":"464.306"},{"Metabolite":"Glycodeoxycholic acid","PubChem identifiers":"3035026","quantitated m/z":"448.310"},{"Metabolite":"GMP","PubChem identifiers":"6804","quantitated m/z":"362.052"},{"Metabolite":"GTP","PubChem identifiers":"6830","quantitated m/z":"521.987"},{"Metabolite":"Guanine","PubChem identifiers":"764","quantitated m/z":"152.059"},{"Metabolite":"Guanosine","PubChem identifiers":"6802","quantitated m/z":"284.100"},{"Metabolite":"Harman","PubChem identifiers":"5281404","quantitated m/z":"183.093"},{"Metabolite":"Heptanoic acid","PubChem identifiers":"8094","quantitated m/z":"129.092"},{"Metabolite":"Hexanoic acid","PubChem identifiers":"8892","quantitated m/z":"115.077"},{"Metabolite":"His","PubChem identifiers":"773","quantitated m/z":"156.078"},{"Metabolite":"His-Glu","PubChem identifiers":"7010583","quantitated m/z":"285.120"},{"Metabolite":"Homocitrulline","PubChem identifiers":"65072","quantitated m/z":"190.120"},{"Metabolite":"Homocysteine","PubChem identifiers":"778","quantitated m/z":"136.044"},{"Metabolite":"Homocysteinesulfinic acid","PubChem identifiers":"161712","quantitated m/z":"166.019"},{"Metabolite":"Homoserine","PubChem identifiers":"12647","quantitated m/z":"120.065"},{"Metabolite":"Homovanillic acid","PubChem identifiers":"1738","quantitated m/z":"181.052"},{"Metabolite":"Hydroxyproline","PubChem identifiers":"5810","quantitated m/z":"132.066"},{"Metabolite":"Hypotaurine","PubChem identifiers":"107812","quantitated m/z":"110.028"},{"Metabolite":"Hypoxanthine","PubChem identifiers":"790","quantitated m/z":"137.046"},{"Metabolite":"Ile","PubChem identifiers":"791","quantitated m/z":"132.103"},{"Metabolite":"IMP","PubChem identifiers":"8582","quantitated m/z":"347.042"},{"Metabolite":"Inosine","PubChem identifiers":"6021","quantitated m/z":"269.089"},{"Metabolite":"Isobutyrylcarnitine","PubChem identifiers":"168379","quantitated m/z":"232.155"},{"Metabolite":"Isovalerylcarnitine","PubChem identifiers":"6426851","quantitated m/z":"246.170"},{"Metabolite":"Kynurenine","PubChem identifiers":"846","quantitated m/z":"209.094"},{"Metabolite":"Lactic acid","PubChem identifiers":"612","quantitated m/z":"89.025"},{"Metabolite":"Lauric acid","PubChem identifiers":"3893","quantitated m/z":"199.172"},{"Metabolite":"Leu","PubChem identifiers":"857","quantitated m/z":"132.103"},{"Metabolite":"Linoleic acid","PubChem identifiers":"5280450","quantitated m/z":"279.236"},{"Metabolite":"Linolenic acid","PubChem identifiers":"5280934","quantitated m/z":"277.220"},{"Metabolite":"Linoleyl ethanolamide","PubChem identifiers":"5283446","quantitated m/z":"324.292"},{"Metabolite":"Lys","PubChem identifiers":"866","quantitated m/z":"147.114"},{"Metabolite":"Malic acid","PubChem identifiers":"525","quantitated m/z":"133.015"},{"Metabolite":"Met","PubChem identifiers":"876","quantitated m/z":"150.059"},{"Metabolite":"Methionine sulfoxide","PubChem identifiers":"158980","quantitated m/z":"166.053"},{"Metabolite":"Morpholine","PubChem identifiers":"8083","quantitated m/z":"88.076"},{"Metabolite":"myo-Inositol 2-phosphate","PubChem identifiers":"160886","quantitated m/z":"259.023"},{"Metabolite":"Myristic acid","PubChem identifiers":"11005","quantitated m/z":"227.204"},{"Metabolite":"N-Acetylalanine","PubChem identifiers":"88064","quantitated m/z":"130.052"},{"Metabolite":"N-Acetylglucosamine 1-phosphate","PubChem identifiers":"440272","quantitated m/z":"300.051"},{"Metabolite":"N-Acetylglucosamine 6-phosphate","PubChem identifiers":"440996","quantitated m/z":"300.051"},{"Metabolite":"N-Acetylhistidine","PubChem identifiers":"75619","quantitated m/z":"198.089"},{"Metabolite":"N-Acetyllysine","PubChem identifiers":"92907","quantitated m/z":"189.124"},{"Metabolite":"N-Acetylmethionine","PubChem identifiers":"448580","quantitated m/z":"190.056"},{"Metabolite":"N-Acetylornithine","PubChem identifiers":"439232","quantitated m/z":"175.109"},{"Metabolite":"N-Acetylputrescine","PubChem identifiers":"122356","quantitated m/z":"131.119"},{"Metabolite":"N-Acetylserine","PubChem identifiers":"65249","quantitated m/z":"148.061"},{"Metabolite":"N-Carbamoylaspartic acid","PubChem identifiers":"93072","quantitated m/z":"175.037"},{"Metabolite":"N-Methylalanine","PubChem identifiers":"5288725","quantitated m/z":"104.071"},{"Metabolite":"N-Methylglutamic acid","PubChem identifiers":"439377","quantitated m/z":"162.076"},{"Metabolite":"N1-Acetylspermidine","PubChem identifiers":"496","quantitated m/z":"188.177"},{"Metabolite":"N5-Ethylglutamine","PubChem identifiers":"439378","quantitated m/z":"175.109"},{"Metabolite":"N6-Acetyllysine","PubChem identifiers":"92832","quantitated m/z":"189.125"},{"Metabolite":"N6-Methyllysine","PubChem identifiers":"164795","quantitated m/z":"161.129"},{"Metabolite":"N8-Acetylspermidine","PubChem identifiers":"123689","quantitated m/z":"188.177"},{"Metabolite":"NAD+","PubChem identifiers":"5893","quantitated m/z":"662.104"},{"Metabolite":"NADP+","PubChem identifiers":"5886","quantitated m/z":"742.069"},{"Metabolite":"NADPH_divalent","PubChem identifiers":"5884","quantitated m/z":"371.542"},{"Metabolite":"Nicotinamide","PubChem identifiers":"936","quantitated m/z":"123.056"},{"Metabolite":"Nicotinic acid","PubChem identifiers":"938","quantitated m/z":"124.040"},{"Metabolite":"NMN","PubChem identifiers":"14180","quantitated m/z":"335.065"},{"Metabolite":"Nω-Methylarginine","PubChem identifiers":"132862","quantitated m/z":"189.136"},{"Metabolite":"O-Acetylcarnitine","PubChem identifiers":"439756","quantitated m/z":"204.124"},{"Metabolite":"O-Acetylserine","PubChem identifiers":"99478","quantitated m/z":"148.061"},{"Metabolite":"O-Phosphoserine","PubChem identifiers":"68841","quantitated m/z":"184.003"},{"Metabolite":"Octanoic acid","PubChem identifiers":"379","quantitated m/z":"143.109"},{"Metabolite":"Oleic acid","PubChem identifiers":"445639","quantitated m/z":"281.252"},{"Metabolite":"Ophthalmic acid","PubChem identifiers":"7018721","quantitated m/z":"290.136"},{"Metabolite":"Ornithine","PubChem identifiers":"389","quantitated m/z":"133.098"},{"Metabolite":"p-Hydroxybenzoic acid","PubChem identifiers":"135","quantitated m/z":"137.025"},{"Metabolite":"Palmitic acid","PubChem identifiers":"985","quantitated m/z":"255.236"},{"Metabolite":"Palmitoleic acid","PubChem identifiers":"445638","quantitated m/z":"253.220"},{"Metabolite":"Palmitoylcarnitine","PubChem identifiers":"11953816","quantitated m/z":"400.345"},{"Metabolite":"Palmitoylethanolamide","PubChem identifiers":"4671","quantitated m/z":"300.293"},{"Metabolite":"Pantothenic acid","PubChem identifiers":"6613","quantitated m/z":"218.105"},{"Metabolite":"Penciclovir","PubChem identifiers":"4725","quantitated m/z":"254.125"},{"Metabolite":"Pentadecanoic acid","PubChem identifiers":"13849","quantitated m/z":"241.220"},{"Metabolite":"Phe","PubChem identifiers":"994","quantitated m/z":"166.087"},{"Metabolite":"Phosphoenolpyruvic acid","PubChem identifiers":"1005","quantitated m/z":"166.976"},{"Metabolite":"Phosphorylcholine","PubChem identifiers":"1014","quantitated m/z":"184.074"},{"Metabolite":"Phytosphingosine","PubChem identifiers":"122121","quantitated m/z":"318.302"},{"Metabolite":"Picolinic acid","PubChem identifiers":"1018","quantitated m/z":"124.040"},{"Metabolite":"Pipecolic acid","PubChem identifiers":"439227","quantitated m/z":"130.087"},{"Metabolite":"Pro","PubChem identifiers":"614","quantitated m/z":"116.071"},{"Metabolite":"Propionic acid","PubChem identifiers":"1032","quantitated m/z":"73.030"},{"Metabolite":"Propionyl CoA_divalent","PubChem identifiers":"92753","quantitated m/z":"410.567"},{"Metabolite":"Prostaglandin B2","PubChem identifiers":"5280881","quantitated m/z":"335.226"},{"Metabolite":"PRPP","PubChem identifiers":"7339","quantitated m/z":"388.946"},{"Metabolite":"Putrescine","PubChem identifiers":"1045","quantitated m/z":"89.108"},{"Metabolite":"Pyridoxal","PubChem identifiers":"1050","quantitated m/z":"168.067"},{"Metabolite":"Pyridoxamine 5'-phosphate","PubChem identifiers":"1053","quantitated m/z":"249.065"},{"Metabolite":"Quinic acid","PubChem identifiers":"6508","quantitated m/z":"191.049"},{"Metabolite":"Riboflavin","PubChem identifiers":"493570","quantitated m/z":"377.147"},{"Metabolite":"Ribose 5-phosphate","PubChem identifiers":"439167","quantitated m/z":"229.013"},{"Metabolite":"Ribulose 5-phosphate","PubChem identifiers":"439184","quantitated m/z":"229.014"},{"Metabolite":"Ricinoleic acid-1","PubChem identifiers":"643684","quantitated m/z":"297.246"},{"Metabolite":"Ricinoleic acid-2","PubChem identifiers":"643684","quantitated m/z":"297.246"},{"Metabolite":"S-Adenosylhomocysteine","PubChem identifiers":"439155","quantitated m/z":"385.130"},{"Metabolite":"S-Adenosylmethionine","PubChem identifiers":"34755","quantitated m/z":"399.146"},{"Metabolite":"S-Methylglutathione","PubChem identifiers":"115260","quantitated m/z":"322.106"},{"Metabolite":"Saccharopine","PubChem identifiers":"160556","quantitated m/z":"277.141"},{"Metabolite":"SDMA","PubChem identifiers":"169148","quantitated m/z":"203.151"},{"Metabolite":"Sedoheptulose 7-phosphate","PubChem identifiers":"165007","quantitated m/z":"289.035"},{"Metabolite":"Ser","PubChem identifiers":"617","quantitated m/z":"106.051"},{"Metabolite":"Spermidine","PubChem identifiers":"1102","quantitated m/z":"146.166"},{"Metabolite":"Sphinganine","PubChem identifiers":"91486","quantitated m/z":"302.309"},{"Metabolite":"Stearic acid","PubChem identifiers":"5281","quantitated m/z":"283.267"},{"Metabolite":"Stearidonic acid","PubChem identifiers":"5312508","quantitated m/z":"275.205"},{"Metabolite":"Stearoyl ethanolamide","PubChem identifiers":"27902","quantitated m/z":"328.319"},{"Metabolite":"Streptomycin sulfate_+H2O_divalent","PubChem identifiers":"19649","quantitated m/z":"300.646"},{"Metabolite":"Succinic acid","PubChem identifiers":"1110","quantitated m/z":"117.020"},{"Metabolite":"Sulfotyrosine","PubChem identifiers":"514186","quantitated m/z":"260.026"},{"Metabolite":"Taurochenodeoxycholic acid","PubChem identifiers":"387316","quantitated m/z":"498.293"},{"Metabolite":"Taurocholic acid","PubChem identifiers":"46783527","quantitated m/z":"514.288"},{"Metabolite":"Taurodeoxycholic acid","PubChem identifiers":"92042745","quantitated m/z":"498.292"},{"Metabolite":"Terephthalic acid","PubChem identifiers":"7489","quantitated m/z":"165.020"},{"Metabolite":"Testosterone","PubChem identifiers":"6013","quantitated m/z":"289.208"},{"Metabolite":"Testosterone acetate","PubChem identifiers":"92145","quantitated m/z":"331.230"},{"Metabolite":"Thiamine","PubChem identifiers":"1130","quantitated m/z":"265.113"},{"Metabolite":"Thiamine phosphate","PubChem identifiers":"1131","quantitated m/z":"345.079"},{"Metabolite":"Thiaproline","PubChem identifiers":"9934","quantitated m/z":"134.028"},{"Metabolite":"Thr","PubChem identifiers":"6288","quantitated m/z":"120.066"},{"Metabolite":"Thr-Asp","PubChem identifiers":"3280446","quantitated m/z":"235.092"},{"Metabolite":"Tiglic acid","PubChem identifiers":"125468","quantitated m/z":"99.046"},{"Metabolite":"trans-Glutaconic acid","PubChem identifiers":"5280498","quantitated m/z":"131.035"},{"Metabolite":"Tricosanoic acid","PubChem identifiers":"17085","quantitated m/z":"353.346"},{"Metabolite":"Triethanolamine","PubChem identifiers":"7618","quantitated m/z":"150.113"},{"Metabolite":"Trilaurin","PubChem identifiers":"10851","quantitated m/z":"656.588"},{"Metabolite":"Trimethylamine N-oxide","PubChem identifiers":"1145","quantitated m/z":"76.076"},{"Metabolite":"Trp","PubChem identifiers":"1148","quantitated m/z":"205.098"},{"Metabolite":"Tyr","PubChem identifiers":"1153","quantitated m/z":"182.082"},{"Metabolite":"Tyr-Arg_divalent","PubChem identifiers":"123804","quantitated m/z":"169.596"},{"Metabolite":"Tyramine","PubChem identifiers":"5610","quantitated m/z":"138.092"},{"Metabolite":"UDP","PubChem identifiers":"6031","quantitated m/z":"402.997"},{"Metabolite":"UDP-glucuronic acid","PubChem identifiers":"17473","quantitated m/z":"579.030"},{"Metabolite":"UMP","PubChem identifiers":"6030","quantitated m/z":"323.031"},{"Metabolite":"Uracil","PubChem identifiers":"1174","quantitated m/z":"113.035"},{"Metabolite":"Urea","PubChem identifiers":"1176","quantitated m/z":"61.040"},{"Metabolite":"Uric acid","PubChem identifiers":"1175","quantitated m/z":"167.023"},{"Metabolite":"Uridine","PubChem identifiers":"6029","quantitated m/z":"245.081"},{"Metabolite":"Urocanic acid","PubChem identifiers":"736715","quantitated m/z":"139.052"},{"Metabolite":"UTP","PubChem identifiers":"6133","quantitated m/z":"482.964"},{"Metabolite":"Val","PubChem identifiers":"1182","quantitated m/z":"118.087"},{"Metabolite":"Xanthine","PubChem identifiers":"1188","quantitated m/z":"153.041"},{"Metabolite":"β-Ala","PubChem identifiers":"239","quantitated m/z":"90.056"},{"Metabolite":"β-Ala-Lys","PubChem identifiers":"440638","quantitated m/z":"218.151"},{"Metabolite":"β-Hydroxyisovaleric acid","PubChem identifiers":"69362","quantitated m/z":"117.056"},{"Metabolite":"γ-Butyrobetaine","PubChem identifiers":"134","quantitated m/z":"146.118"},{"Metabolite":"γ-Glu-Cys","PubChem identifiers":"123938","quantitated m/z":"251.070"}]
}

}