{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002284","ANALYSIS_ID":"AN003732","VERSION":"1","CREATED_ON":"01-26-2024"},
"PROJECT":{"PROJECT_TITLE":"Comparing water-soluble metabolites and lipid changes on human organoids and corresponding culture medium with different genotypes at different culturing stages","PROJECT_SUMMARY":"Quantitative metabolome and lipidome analysis of human brain organoids with different genetic mutations. Water-soluble metabolites were extracted from 1- and 4-month-old WT, PT, PTCC, and PTN organoids and their respective culture medium.","INSTITUTE":"DKFZ","DEPARTMENT":"Molecular Neurogenetics","LABORATORY":"Molecular Neurogenetics","LAST_NAME":"Wang","FIRST_NAME":"Changwen","ADDRESS":"Im Neuenheimer Feld 581, Heidelberg, Baden-Wurttemberg, 69120, Germany","EMAIL":"c.wang@dkfz-heidelberg.de","PHONE":"+49 6221 42 3455","PUBLICATIONS":"https://www.nature.com/articles/s41698-024-00500-5, https://pubmed.ncbi.nlm.nih.gov/38273014/","DOI":"http://dx.doi.org/10.21228/M8GT5D"},
"STUDY":{"STUDY_TITLE":"Genetically defined human GBM organoids reveal principles of GBM development and actionable targets","STUDY_SUMMARY":"Recent advances in glioblastoma (GBM) studies provide a comprehensive catalog of its genetic aberrations and cellular heterogeneity. However, a solid understanding of genotype-based analysis of cancer pathway dependency and actionable target identification is required to transform GBM treatment into a personalized era. Here, we generated a spectrum of mutant iPSCs harboring frequent GBM mutations with CRISPR/Cas9 and profiled the organoids (LEGO: Laboratory Engineered Glioblastoma Organoid) derived from these iPSCs temporally on transcriptome, methylome, metabolome, lipidome, proteome, and phospho-proteome levels. We found that LEGOs form brain tumors in vivo and recapitulate critical features of human GBM. The multi-omics analysis discovered essential milestones driven by genetic heterogeneity during GBM progressions, such as lineage alteration, methylome rewriting, and metabolome/lipidome reprogramming, in concordance with altered pathway activity and drug response. This study provides a tool and research path to realizing genome-based personalized GBM therapy using novel advanced models.","INSTITUTE":"DKFZ","DEPARTMENT":"Molecular Neurogenetics","LABORATORY":"Molecular Neurogenetics","LAST_NAME":"Wang","FIRST_NAME":"Changwen","ADDRESS":"Im Neuenheimer Feld 581","EMAIL":"c.wang@dkfz-heidelberg.de","PHONE":"+49 6221 42 3455","SUBMIT_DATE":"2022-09-17"},
"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S21_1m_woCells_1",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S21_1m_woCells_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S22_1m_woCells_2",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S22_1m_woCells_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S23_1m_woCells_3",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S23_1m_woCells_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S24_1m_woCells_4",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S24_1m_woCells_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S25_1m_woCells_5",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S25_1m_woCells_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S21_1m_woCells_1",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S21_1m_woCells_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S22_1m_woCells_2",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S22_1m_woCells_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S23_1m_woCells_3",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S23_1m_woCells_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S24_1m_woCells_4",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S24_1m_woCells_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S25_1m_woCells_5",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S25_1m_woCells_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S46_4m_woCells_1",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S46_4m_woCells_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S47_4m_woCells_2",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S47_4m_woCells_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S48_4m_woCells_3",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S48_4m_woCells_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S49_4m_woCells_4",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S49_4m_woCells_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S50_4m_woCells_5",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S50_4m_woCells_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S46_4m_woCells_1",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S46_4m_woCells_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S47_4m_woCells_2",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S47_4m_woCells_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S48_4m_woCells_3",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S48_4m_woCells_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S49_4m_woCells_4",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S49_4m_woCells_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S50_4m_woCells_5",
"Factors":{"Genotype":"NA, blank medium control","Age":"NA, same batch medium as 4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S50_4m_woCells_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S11_1m_PTCC_1",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S11_1m_PTCC_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S12_1m_PTCC_2",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S12_1m_PTCC_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S13_1m_PTCC_3",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S13_1m_PTCC_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S14_1m_PTCC_4",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S14_1m_PTCC_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S15_1m_PTCC_5",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S15_1m_PTCC_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S11_1m_PTCC_1",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S11_1m_PTCC_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S12_1m_PTCC_2",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S12_1m_PTCC_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S13_1m_PTCC_3",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S13_1m_PTCC_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S14_1m_PTCC_4",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S14_1m_PTCC_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S15_1m_PTCC_5",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S15_1m_PTCC_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S11_1m_PTCC_1",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S11_1m_PTCC_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S12_1m_PTCC_2",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S12_1m_PTCC_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S13_1m_PTCC_3",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S13_1m_PTCC_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S14_1m_PTCC_4",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S14_1m_PTCC_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S15_1m_PTCC_5",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S15_1m_PTCC_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S11_1m_PTCC_1",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S11_1m_PTCC_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S12_1m_PTCC_2",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S12_1m_PTCC_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S13_1m_PTCC_3",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S13_1m_PTCC_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S14_1m_PTCC_4",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S14_1m_PTCC_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S15_1m_PTCC_5",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S15_1m_PTCC_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S36_4m_PTCC_1",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S36_4m_PTCC_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S37_4m_PTCC_2",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S37_4m_PTCC_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S38_4m_PTCC_3",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S38_4m_PTCC_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S39_4m_PTCC_4",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S39_4m_PTCC_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S40_4m_PTCC_5",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S40_4m_PTCC_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S36_4m_PTCC_1",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S36_4m_PTCC_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S37_4m_PTCC_2",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S37_4m_PTCC_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S38_4m_PTCC_3",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S38_4m_PTCC_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S39_4m_PTCC_4",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S39_4m_PTCC_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S40_4m_PTCC_5",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S40_4m_PTCC_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S31_4m_PTCC_1",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S31_4m_PTCC_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S32_4m_PTCC_2",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S32_4m_PTCC_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S33_4m_PTCC_3",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S33_4m_PTCC_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S34_4m_PTCC_4",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S34_4m_PTCC_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S35_4m_PTCC_5",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S35_4m_PTCC_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S31_4m_PTCC_1",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S31_4m_PTCC_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S32_4m_PTCC_2",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S32_4m_PTCC_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S33_4m_PTCC_3",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S33_4m_PTCC_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S34_4m_PTCC_4",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S34_4m_PTCC_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S35_4m_PTCC_5",
"Factors":{"Genotype":"PTCC; PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S35_4m_PTCC_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S16_1m_PTN_1",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S16_1m_PTN_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S17_1m_PTN_2",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S17_1m_PTN_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S18_1m_PTN_3",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S18_1m_PTN_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S19_1m_PTN_4",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S19_1m_PTN_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S20_1m_PTN_5",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S20_1m_PTN_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S16_1m_PTN_1",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S16_1m_PTN_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S17_1m_PTN_2",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S17_1m_PTN_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S18_1m_PTN_3",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S18_1m_PTN_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S19_1m_PTN_4",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S19_1m_PTN_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S20_1m_PTN_5",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S20_1m_PTN_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S16_1m_PTN_1",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S16_1m_PTN_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S17_1m_PTN_2",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S17_1m_PTN_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S18_1m_PTN_3",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S18_1m_PTN_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S19_1m_PTN_4",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S19_1m_PTN_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S20_1m_PTN_5",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S20_1m_PTN_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S16_1m_PTN_1",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S16_1m_PTN_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S17_1m_PTN_2",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S17_1m_PTN_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S18_1m_PTN_3",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S18_1m_PTN_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S19_1m_PTN_4",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S19_1m_PTN_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S20_1m_PTN_5",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S20_1m_PTN_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S41_4m_PTN_1",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S41_4m_PTN_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S42_4m_PTN_2",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S42_4m_PTN_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S43_4m_PTN_3",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S43_4m_PTN_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S44_4m_PTN_4",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S44_4m_PTN_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S45_4m_PTN_5",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S45_4m_PTN_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S41_4m_PTN_1",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S41_4m_PTN_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S42_4m_PTN_2",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S42_4m_PTN_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S43_4m_PTN_3",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S43_4m_PTN_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S44_4m_PTN_4",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S44_4m_PTN_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S45_4m_PTN_5",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S45_4m_PTN_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S36_4m_PTN_1",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S36_4m_PTN_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S37_4m_PTN_2",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S37_4m_PTN_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S38_4m_PTN_3",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S38_4m_PTN_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S39_4m_PTN_4",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S39_4m_PTN_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S40_4m_PTN_5",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S40_4m_PTN_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S36_4m_PTN_1",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S36_4m_PTN_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S37_4m_PTN_2",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S37_4m_PTN_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S38_4m_PTN_3",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S38_4m_PTN_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S39_4m_PTN_4",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S39_4m_PTN_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S40_4m_PTN_5",
"Factors":{"Genotype":"PTN; PTEN-/-; TP53-/-; NF1-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S40_4m_PTN_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S06_1m_PT_1",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S06_1m_PT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S07_1m_PT_2",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S07_1m_PT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S08_1m_PT_3",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S08_1m_PT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S09_1m_PT_4",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S09_1m_PT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S10_1m_PT_5",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S10_1m_PT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S06_1m_PT_1",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S06_1m_PT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S07_1m_PT_2",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S07_1m_PT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S08_1m_PT_3",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S08_1m_PT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S09_1m_PT_4",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S09_1m_PT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S10_1m_PT_5",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S10_1m_PT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S06_1m_PT_1",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S06_1m_PT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S07_1m_PT_2",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S07_1m_PT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S08_1m_PT_3",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S08_1m_PT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S09_1m_PT_4",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S09_1m_PT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S10_1m_PT_5",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S10_1m_PT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S06_1m_PT_1",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S06_1m_PT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S07_1m_PT_2",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S07_1m_PT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S08_1m_PT_3",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S08_1m_PT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S08_1m_PT_4",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S08_1m_PT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S10_1m_PT_5",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S10_1m_PT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S31_4m_PT_1",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S31_4m_PT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S32_4m_PT_2",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S32_4m_PT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S33_4m_PT_3",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S33_4m_PT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S34_4m_PT_4",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S34_4m_PT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S35_4m_PT_5",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S35_4m_PT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S31_4m_PT_1",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S31_4m_PT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S32_4m_PT_2",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S32_4m_PT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S33_4m_PT_3",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S33_4m_PT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S34_4m_PT_4",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S34_4m_PT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S35_4m_PT_5",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S35_4m_PT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S26_4m_PT_1",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S26_4m_PT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S27_4m_PT_2",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S27_4m_PT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S28_4m_PT_3",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S28_4m_PT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S29_4m_PT_4",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S29_4m_PT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S30_4m_PT_5",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S30_4m_PT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S26_4m_PT_1",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S26_4m_PT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S27_4m_PT_2",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S27_4m_PT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S28_4m_PT_3",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S28_4m_PT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S29_4m_PT_4",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S29_4m_PT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S30_4m_PT_5",
"Factors":{"Genotype":"PT; PTEN-/-; TP53-/-","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S30_4m_PT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S01_1m_WT_1",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S01_1m_WT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S02_1m_WT_2",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S02_1m_WT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S03_1m_WT_3",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S03_1m_WT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S04_1m_WT_4",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S04_1m_WT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S05_1m_WT_5",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S05_1m_WT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S01_1m_WT_1",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S01_1m_WT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S02_1m_WT_2",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S02_1m_WT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S03_1m_WT_3",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S03_1m_WT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S04_1m_WT_4",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S04_1m_WT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S05_1m_WT_5",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S05_1m_WT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S01_1m_WT_1",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S01_1m_WT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S02_1m_WT_2",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S02_1m_WT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S03_1m_WT_3",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S03_1m_WT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S04_1m_WT_4",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S04_1m_WT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S05_1m_WT_5",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S05_1m_WT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S01_1m_WT_1",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S01_1m_WT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S02_1m_WT_2",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S02_1m_WT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S03_1m_WT_3",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S03_1m_WT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S04_1m_WT_4",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S04_1m_WT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S05_1m_WT_5",
"Factors":{"Genotype":"WT; wildtype","Age":"1-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S05_1m_WT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S26_4m_WT_1",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S26_4m_WT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S27_4m_WT_2",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S27_4m_WT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S28_4m_WT_3",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S28_4m_WT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S29_4m_WT_4",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S29_4m_WT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_Lip_S30_4m_WT_5",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Med_Lip_S30_4m_WT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S26_4m_WT_1",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S26_4m_WT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S27_4m_WT_2",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S27_4m_WT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S28_4m_WT_3",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S28_4m_WT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S29_4m_WT_4",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S29_4m_WT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Med_S30_4m_WT_5",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Culture medium"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Med_S30_4m_WT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S21_4m_WT_1",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S21_4m_WT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S22_4m_WT_2",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S22_4m_WT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S23_4m_WT_3",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S23_4m_WT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S24_4m_WT_4",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S24_4m_WT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Lip_Org_S25_4m_WT_5",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Lipids","RAW_FILE_NAME":"LS21_049_Lip_Org_S25_4m_WT_5.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S21_4m_WT_1",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S21_4m_WT_1.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S22_4m_WT_2",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S22_4m_WT_2.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S23_4m_WT_3",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S23_4m_WT_3.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S24_4m_WT_4",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S24_4m_WT_4.mzML"}
},
{
"Subject ID":"-",
"Sample ID":"LS21_049_Org_S25_4m_WT_5",
"Factors":{"Genotype":"WT; wildtype","Age":"4-month-old","Extracted Sample":"Organoid"},
"Additional sample data":{"Analyzed target":"Water-soluble metabolites","RAW_FILE_NAME":"LS21_049_Org_S25_4m_WT_5.mzML"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Organoid samples were quickly washed with 154 mM ammonium acetate on ice and snap-frozen in liquid nitrogen. The medium samples were collected from each well and snap-frozen in liquid nitrogen. All samples were stored at -80°C before extraction.","SAMPLE_TYPE":"Organoid","STORAGE_CONDITIONS":"-80℃"},
"TREATMENT":{"TREATMENT_SUMMARY":"Not applicable"},
"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Water-soluble metabolites and lipids were extracted from the organoids and corresponding culture medium. Details are described in the Sampleprep Protocol Files (WSplusLipid.pdf)"},
"CHROMATOGRAPHY":{"METHODS_FILENAME":"WSplusLipid.pdf","INSTRUMENT_NAME":"Thermo Dionex Ultimate 3000","COLUMN_NAME":"Thermo Accucore HILIC (100 x 2.1mm,2.6um)","CHROMATOGRAPHY_TYPE":"HILIC"},
"ANALYSIS":{"ANALYSIS_TYPE":"MS","ANALYSIS_PROTOCOL_FILE":"WSplusLipid.pdf"},
"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Plus Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","MS_COMMENTS":"-","ION_MODE":"POSITIVE"},
"MS_METABOLITE_DATA":{
"Units":"peak intensity",
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}