{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002323","ANALYSIS_ID":"AN003792","VERSION":"1","CREATED_ON":"October 26, 2022, 11:45 am"},

"PROJECT":{"PROJECT_TITLE":"SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia","PROJECT_SUMMARY":"Histone methyltransferase SETD1A is critical for acute myeloid leukemia (AML) cell survival, but the molecular mechanism driving SETD1A gene regulation remains elusive. To delineate the role of SETD1A, we utilize a protein degrader technology to induce rapid SETD1A degradation in AML cell lines. SETD1A degradation results in immediate downregulation of transcripts associated with DNA repair and heme biosynthesis pathways. CRISPR-based functional analyses and metabolomics reveal an essential role of SETD1A to maintain mitochondrial respiration in AML cells. These SETD1A targets are enriched in head-to-head (H2H) genes. SETD1A degradation disrupts a non-enzymatic SETD1A domain-dependent cyclin K function, increases the Ser5P RNA polymerase II (RNAP2) at TSS, and induces the promoter-proximal pausing of RNAP2 in a strand-specific manner. This study reveals a non-enzymatic role for SETD1A in transcriptional pause release and provides insight into the mechanism of RNAP2 pausing and its function in cancer.","INSTITUTE":"Chiba University","LAST_NAME":"Hoshii","FIRST_NAME":"Takayuki","ADDRESS":"1-8-1 Inohana Chuo-ku, Chiba, Chiba, 2608670, Japan","EMAIL":"hoshiit@chiba-u.jp","PHONE":"81432262039"},

"STUDY":{"STUDY_TITLE":"SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia","STUDY_SUMMARY":"Histone methyltransferase SETD1A is critical for acute myeloid leukemia (AML) cell survival, but the molecular mechanism driving SETD1A gene regulation remains elusive. To delineate the role of SETD1A, we utilize a protein degrader technology to induce rapid SETD1A degradation in AML cell lines. SETD1A degradation results in immediate downregulation of transcripts associated with DNA repair and heme biosynthesis pathways. CRISPR-based functional analyses and metabolomics reveal an essential role of SETD1A to maintain mitochondrial respiration in AML cells. These SETD1A targets are enriched in head-to-head (H2H) genes. SETD1A degradation disrupts a non-enzymatic SETD1A domain-dependent cyclin K function, increases the Ser5P RNA polymerase II (RNAP2) at TSS, and induces the promoter-proximal pausing of RNAP2 in a strand-specific manner. This study reveals a non-enzymatic role for SETD1A in transcriptional pause release and provides insight into the mechanism of RNAP2 pausing and its function in cancer.","INSTITUTE":"Chiba University","LAST_NAME":"Hoshii","FIRST_NAME":"Takayuki","ADDRESS":"1-8-1 Inohana Chuo-ku, Chiba, Chiba, 2608670, Japan","EMAIL":"hoshiit@chiba-u.jp","PHONE":"81432262039"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606","CELL_STRAIN_DETAILS":"MOLM-13 cells expressing FKBPF36V-tagged SETD1A"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"1",
"Factors":{"Condition":"DMSO_24h"}
},
{
"Subject ID":"-",
"Sample ID":"2",
"Factors":{"Condition":"DMSO_24h"}
},
{
"Subject ID":"-",
"Sample ID":"3",
"Factors":{"Condition":"DMSO_24h"}
},
{
"Subject ID":"-",
"Sample ID":"4",
"Factors":{"Condition":"dTAG-13_24h"}
},
{
"Subject ID":"-",
"Sample ID":"5",
"Factors":{"Condition":"dTAG-13_24h"}
},
{
"Subject ID":"-",
"Sample ID":"6",
"Factors":{"Condition":"dTAG-13_24h"}
},
{
"Subject ID":"-",
"Sample ID":"7",
"Factors":{"Condition":"DMSO_48h"}
},
{
"Subject ID":"-",
"Sample ID":"8",
"Factors":{"Condition":"DMSO_48h"}
},
{
"Subject ID":"-",
"Sample ID":"9",
"Factors":{"Condition":"DMSO_48h"}
},
{
"Subject ID":"-",
"Sample ID":"10",
"Factors":{"Condition":"dTAG-13_48h"}
},
{
"Subject ID":"-",
"Sample ID":"11",
"Factors":{"Condition":"dTAG-13_48h"}
},
{
"Subject ID":"-",
"Sample ID":"12",
"Factors":{"Condition":"dTAG-13_48h"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Metabolomic profiling was conducted for triplicated DMSO/dTAG-13 treated leukemia cell extracts via capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) by using Agilent 7100 CE capillary electrophoresis (Agilent Technologies), the Agilent 6230 LC/MSD TOF system (Agilent Technologies), an Agilent1100 series binary HPLC pump, and the G1603A Agilent CE-MS adapter- and G1607A Agilent CE-ESI-MS sprayer kit.","SAMPLE_TYPE":"Leukemia cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"Cells were treated with dTAG-13 for 24 h or 48 h.","TREATMENT_COMPOUND":"dTAG-13"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"For anionic metabolite analysis, the original Agilent stainless ESI needle was replaced with the Agilent G7100-60041 platinum ESI needle. System control and data acquisition were performed by Agilent MassHunter Workstation, and data analysis was done by Keio MasterHands software. For cationic metabolite analysis, separations were carried out in a fused silica capillary (50 µm i.d. x 100 cm total length) filled with 1 M formic acid as the electrolyte. Approximately 5 nL of sample solution were injected at 50 mbar for 5 sec and 30 kV of voltage was applied. The capillary temperature was maintained at 20 ºC and the sample tray was cooled below 5 ºC. Methanol-water (50 % v/v) containing 0.01 µM Hexakis(2,2-difluoroethoxy)phosphazene was delivered as the sheath liquid at 10 µL/min."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"For anionic metabolite analysis, a commercially available COSMO(+) (chemically coated with cationic polymer) capillary (50 µm i.d. x 105 cm total length) (Nacalai Tesque, Kyoto, Japan) was used with a 50 mM ammonium acetate solution (pH 8.5) as the electrolyte. Sample solution (30 nL) was injected at 50 mbar for 30 sec and -30 kV of voltage was applied. Ammonium acetate (5 mM) in 50 % methanol-water (v/v) containing 0.01 µM Hexakis(2,2-difluoroethoxy)phosphazene was delivered as the sheath liquid at 10 µl/min.","CHROMATOGRAPHY_TYPE":"CE","INSTRUMENT_NAME":"Agilent 7100 CE","COLUMN_NAME":"COSMO(+) (chemically coated with cationic polymer) capillary (50 µm i.d. x 105 cm total length) (Nacalai Tesque, Kyoto, Japan)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 6230 TOF","INSTRUMENT_TYPE":"QTOF","MS_TYPE":"ESI","ION_MODE":"NEGATIVE","MS_COMMENTS":"ESI-TOFMS was conducted in the negative ion mode; the capillary voltage was set at 3,500 V. For TOFMS, the fragmentor-, skimmer-, and Oct RFV voltage was set at 100 V, 50 V, and 500 V, respectively. Automatic recalibration of each acquired spectrum was performed using reference masses of reference standards, i.e., 13C isotopic ion of deprotonated acetic acid dimer ([2CH3COOH-H]-, m/z 120.0384), and Hexakis + deprotonated acetic acid (m/z 680.03554) provided the lock mass for exact mass measurements."},

"MS_METABOLITE_DATA":{
"Units":"fmol/cell",

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CorMT":"17.90"},{"Metabolite":"6-Hydroxyhexanoate","Ave m/z":"131.0718","Ave CorMT":"18.48"},{"Metabolite":"Threonate","Ave m/z":"135.0314","Ave CorMT":"16.98"},{"Metabolite":"o-Hydroxybenzoate","Ave m/z":"137.0261","Ave CorMT":"15.33"},{"Metabolite":"p-Hydroxybenzoate","Ave m/z":"137.0249","Ave CorMT":"16.71"},{"Metabolite":"m-Hydroxybenzoate","Ave m/z":"137.0262","Ave CorMT":"16.96"},{"Metabolite":"Phosphonoacetate","Ave m/z":"138.9825","Ave CorMT":"11.24"},{"Metabolite":"Carbamoylphosphate","Ave m/z":"139.9770","Ave CorMT":"11.63"},{"Metabolite":"Ethanolamine phosphate","Ave m/z":"140.0129","Ave CorMT":"20.07"},{"Metabolite":"2-Thiopheneacetate","Ave m/z":"141.0041","Ave CorMT":"16.53"},{"Metabolite":"Octanoate","Ave m/z":"143.1084","Ave CorMT":"19.11"},{"Metabolite":"Adipate","Ave m/z":"145.0515","Ave CorMT":"12.40"},{"Metabolite":"threo-beta-methylaspartate","Ave m/z":"146.0475","Ave CorMT":"17.86"},{"Metabolite":"4-Methylthio-2-oxobutyrate","Ave m/z":"147.0179","Ave CorMT":"16.05"},{"Metabolite":"Citramalate","Ave m/z":"147.0312","Ave CorMT":"11.64"},{"Metabolite":"trans-Cinnamate","Ave m/z":"147.0469","Ave CorMT":"17.73"},{"Metabolite":"Tartrate","Ave m/z":"149.0104","Ave CorMT":"10.81"},{"Metabolite":"Benzoylformate","Ave m/z":"149.0255","Ave CorMT":"16.04"},{"Metabolite":"3-Phenylpropionate","Ave m/z":"149.0616","Ave CorMT":"17.94"},{"Metabolite":"2-Hydroxyphenylacetate","Ave m/z":"151.0418","Ave CorMT":"17.44"},{"Metabolite":"p-Hydroxyphenylacetate","Ave m/z":"151.0412","Ave CorMT":"18.09"},{"Metabolite":"Cysteine sulfinate","Ave m/z":"152.0039","Ave CorMT":"16.43"},{"Metabolite":"2,5-Dihydroxybenzoate","Ave m/z":"153.0202","Ave CorMT":"16.47"},{"Metabolite":"Orotate","Ave m/z":"155.0109","Ave CorMT":"15.89"},{"Metabolite":"2,4-Dihydroxypyrimidine-5-carboxylate","Ave m/z":"155.0115","Ave CorMT":"16.32"},{"Metabolite":"Dihydroorotate","Ave m/z":"157.0270","Ave CorMT":"16.64"},{"Metabolite":"2-Oxooctanoate","Ave m/z":"157.0888","Ave CorMT":"17.90"},{"Metabolite":"Pelargonate","Ave m/z":"157.1247","Ave CorMT":"19.81"},{"Metabolite":"2-Oxoadipate","Ave m/z":"159.0311","Ave CorMT":"11.55"},{"Metabolite":"Pimelate","Ave m/z":"159.0673","Ave CorMT":"12.90"},{"Metabolite":"2-Hydroxyoctanoate","Ave m/z":"159.1039","Ave CorMT":"19.34"},{"Metabolite":"N-Formylaspartate","Ave m/z":"160.0270","Ave CorMT":"11.64"},{"Metabolite":"3-Hydroxy-3-methylglutarate","Ave m/z":"161.0476","Ave CorMT":"12.21"},{"Metabolite":"Phenylpyruvate","Ave m/z":"163.0409","Ave CorMT":"17.15"},{"Metabolite":"p-Coumarate","Ave m/z":"163.0416","Ave CorMT":"18.04"},{"Metabolite":"o-Coumarate","Ave m/z":"163.0415","Ave CorMT":"18.21"},{"Metabolite":"Terephthalate","Ave m/z":"165.0207","Ave CorMT":"11.85"},{"Metabolite":"Phthalate","Ave m/z":"165.0206","Ave CorMT":"12.27"},{"Metabolite":"3-Phenyllactate","Ave m/z":"165.0571","Ave CorMT":"18.25"},{"Metabolite":"3-(2-Hydroxyphenyl)propionate","Ave m/z":"165.0569","Ave CorMT":"18.46"},{"Metabolite":"3-(4-Hydroxyphenyl)propionate","Ave m/z":"165.0572","Ave CorMT":"18.99"},{"Metabolite":"2,3-Pyridinedicarboxylate","Ave m/z":"166.0158","Ave CorMT":"12.12"},{"Metabolite":"Urate","Ave m/z":"167.0229","Ave CorMT":"17.63"},{"Metabolite":"4-Hydroxymandelate","Ave m/z":"167.0367","Ave CorMT":"18.30"},{"Metabolite":"Cysteate","Ave m/z":"167.9993","Ave CorMT":"14.60"},{"Metabolite":"2-Amino-3-phosphonopropionate","Ave m/z":"168.0085","Ave CorMT":"13.39"},{"Metabolite":"Decanoate","Ave m/z":"171.1404","Ave CorMT":"20.53"},{"Metabolite":"2-Quinolinecarboxylate","Ave m/z":"172.0412","Ave CorMT":"18.04"},{"Metabolite":"N-Acetylleucine","Ave m/z":"172.0991","Ave CorMT":"20.18"},{"Metabolite":"Phenyl phosphate","Ave m/z":"173.0025","Ave CorMT":"13.33"},{"Metabolite":"trans-Aconitate","Ave m/z":"173.0106","Ave CorMT":"10.03"},{"Metabolite":"Shikimate","Ave m/z":"173.0469","Ave CorMT":"19.44"},{"Metabolite":"N-Acetylaspartate","Ave m/z":"174.0426","Ave CorMT":"12.49"},{"Metabolite":"Carbamoylaspartate","Ave m/z":"175.0373","Ave CorMT":"12.18"},{"Metabolite":"Allantoate","Ave m/z":"175.0486","Ave CorMT":"17.98"},{"Metabolite":"2-Isopropylmalate","Ave m/z":"175.0628","Ave CorMT":"12.86"},{"Metabolite":"N-Formylmethionine","Ave m/z":"176.0401","Ave CorMT":"18.28"},{"Metabolite":"Hippurate","Ave m/z":"178.0529","Ave CorMT":"18.72"},{"Metabolite":"Homovanillate","Ave m/z":"181.0515","Ave CorMT":"19.32"},{"Metabolite":"4-Pyridoxate","Ave m/z":"182.0477","Ave CorMT":"18.07"},{"Metabolite":"Serine O-sulfate","Ave m/z":"183.9931","Ave CorMT":"14.81"},{"Metabolite":"O-Phosphoserine","Ave m/z":"184.0035","Ave CorMT":"13.65"},{"Metabolite":"Undecanoate","Ave m/z":"185.1566","Ave CorMT":"21.34"},{"Metabolite":"Azelate","Ave m/z":"187.0996","Ave CorMT":"13.80"},{"Metabolite":"10-Hydroxydecanoate","Ave m/z":"187.1361","Ave CorMT":"21.28"},{"Metabolite":"N-Acetylglutamate","Ave m/z":"188.0584","Ave CorMT":"13.12"},{"Metabolite":"N-Carbamylglutamate","Ave m/z":"189.0531","Ave CorMT":"12.79"},{"Metabolite":"N-Acetylmethionine","Ave m/z":"190.0563","Ave CorMT":"19.72"},{"Metabolite":"Quinate","Ave m/z":"191.0579","Ave CorMT":"19.34"},{"Metabolite":"Phenaceturate","Ave m/z":"192.0683","Ave CorMT":"19.40"},{"Metabolite":"Glucuronate","Ave m/z":"193.0365","Ave CorMT":"19.80"},{"Metabolite":"trans-4-Hydroxy-3-methoxycinnamate","Ave m/z":"193.0511","Ave CorMT":"19.07"},{"Metabolite":"o-Hydroxyhippurate","Ave m/z":"194.0479","Ave CorMT":"15.65"},{"Metabolite":"Gluconate","Ave m/z":"195.0526","Ave CorMT":"19.57"},{"Metabolite":"Syringate","Ave m/z":"197.0461","Ave CorMT":"18.77"},{"Metabolite":"4-Hydroxy-3-methoxymandelate","Ave m/z":"197.0475","Ave CorMT":"19.49"},{"Metabolite":"Dodecanoate","Ave m/z":"199.1723","Ave CorMT":"23.03"},{"Metabolite":"Cysteine S-sulfate","Ave m/z":"199.9708","Ave CorMT":"14.83"},{"Metabolite":"Sebacate","Ave m/z":"201.1152","Ave CorMT":"14.21"},{"Metabolite":"3-Indolebutyrate","Ave m/z":"202.0891","Ave CorMT":"20.07"},{"Metabolite":"Xanthurenate","Ave m/z":"204.0323","Ave CorMT":"13.62"},{"Metabolite":"N-Acetylphenylalanine","Ave m/z":"206.0844","Ave CorMT":"20.31"},{"Metabolite":"Benzylsuccinate","Ave m/z":"207.0683","Ave CorMT":"13.54"},{"Metabolite":"Saccharate","Ave m/z":"209.0323","Ave CorMT":"12.53"},{"Metabolite":"Mucate","Ave m/z":"209.0324","Ave CorMT":"12.74"},{"Metabolite":"3-Indoxyl sulfate","Ave m/z":"212.0049","Ave CorMT":"16.55"},{"Metabolite":"2-Deoxyribose 1-phosphate","Ave m/z":"213.0184","Ave CorMT":"14.79"},{"Metabolite":"Pantothenate","Ave m/z":"218.1050","Ave CorMT":"21.37"},{"Metabolite":"Sinapate","Ave m/z":"223.0633","Ave CorMT":"20.31"},{"Metabolite":"Porphobilinogen","Ave m/z":"225.0900","Ave CorMT":"21.87"},{"Metabolite":"Dodecanedioate","Ave m/z":"229.1468","Ave CorMT":"14.99"},{"Metabolite":"2-Deoxyglucose 6-phosphate","Ave m/z":"243.0291","Ave CorMT":"15.57"},{"Metabolite":"Biotin","Ave m/z":"243.0831","Ave CorMT":"21.22"},{"Metabolite":"Sorbitol 6-phosphate","Ave m/z":"261.0398","Ave CorMT":"15.80"},{"Metabolite":"Galacturonate 1-phosphate","Ave m/z":"273.0043","Ave CorMT":"12.84"},{"Metabolite":"N-Acetylmuramate","Ave m/z":"292.1059","Ave CorMT":"23.34"},{"Metabolite":"N-Acetylglucosamine 1-phosphate","Ave m/z":"300.0515","Ave CorMT":"16.41"},{"Metabolite":"N-Acetylglucosamine 6-phosphate","Ave m/z":"300.0511","Ave CorMT":"17.07"},{"Metabolite":"2',3'-cCMP","Ave m/z":"304.0362","Ave CorMT":"21.57"},{"Metabolite":"dCMP","Ave m/z":"306.0521","Ave CorMT":"16.09"},{"Metabolite":"dUMP","Ave m/z":"307.0359","Ave CorMT":"15.83"},{"Metabolite":"N-Acetylneuraminate","Ave m/z":"308.1011","Ave CorMT":"23.78"},{"Metabolite":"Ribulose 1,5-diphosphate","Ave m/z":"308.9805","Ave CorMT":"12.04"},{"Metabolite":"3',5'-Cyclic dAMP","Ave m/z":"312.0528","Ave CorMT":"21.54"},{"Metabolite":"dTMP","Ave m/z":"321.0517","Ave CorMT":"16.38"},{"Metabolite":"CMP","Ave m/z":"322.0473","Ave CorMT":"16.31"},{"Metabolite":"UMP","Ave m/z":"323.0298","Ave CorMT":"16.07"},{"Metabolite":"cAMP","Ave m/z":"328.0476","Ave CorMT":"22.01"},{"Metabolite":"cIMP","Ave m/z":"329.0314","Ave CorMT":"20.22"},{"Metabolite":"dAMP","Ave m/z":"330.0637","Ave CorMT":"16.68"},{"Metabolite":"cGMP","Ave m/z":"344.0424","Ave CorMT":"21.63"},{"Metabolite":"3'-AMP","Ave m/z":"346.0582","Ave CorMT":"16.19"},{"Metabolite":"AMP","Ave m/z":"346.0583","Ave CorMT":"16.88"},{"Metabolite":"IMP","Ave m/z":"347.0419","Ave CorMT":"16.39"},{"Metabolite":"Prostaglandin E2","Ave m/z":"351.2202","Ave CorMT":"25.71"},{"Metabolite":"Prostaglandin F2alpha","Ave m/z":"353.2361","Ave CorMT":"26.12"},{"Metabolite":"GMP","Ave m/z":"362.0536","Ave CorMT":"17.09"},{"Metabolite":"XMP","Ave m/z":"363.0374","Ave CorMT":"13.43"},{"Metabolite":"Orotidine 5'-monophosphate","Ave m/z":"367.0210","Ave CorMT":"13.47"},{"Metabolite":"Digalacturonate","Ave m/z":"369.0700","Ave CorMT":"16.43"},{"Metabolite":"NADPH","Ave m/z":"371.5417","Ave CorMT":"14.35"},{"Metabolite":"CoA","Ave m/z":"382.5540","Ave CorMT":"15.02"},{"Metabolite":"dCDP","Ave m/z":"386.0180","Ave CorMT":"14.07"},{"Metabolite":"dUDP","Ave m/z":"387.0024","Ave CorMT":"13.94"},{"Metabolite":"PRPP","Ave m/z":"388.9492","Ave CorMT":"11.79"},{"Metabolite":"dTDP","Ave m/z":"401.0183","Ave CorMT":"14.33"},{"Metabolite":"CDP","Ave m/z":"402.0135","Ave CorMT":"14.21"},{"Metabolite":"UDP","Ave m/z":"402.9973","Ave CorMT":"14.08"},{"Metabolite":"Cholate","Ave m/z":"407.2830","Ave CorMT":"26.49"},{"Metabolite":"dADP","Ave m/z":"410.0296","Ave CorMT":"14.64"},{"Metabolite":"P1, P4-Di(adenosine-5') tetraphosphate","Ave m/z":"417.0205","Ave CorMT":"14.96"},{"Metabolite":"Isobutyryl CoA","Ave m/z":"417.5757","Ave CorMT":"15.78"},{"Metabolite":"Trehalose 6-phosphate","Ave m/z":"421.0779","Ave CorMT":"18.71"},{"Metabolite":"Malonyl CoA","Ave m/z":"425.5549","Ave CorMT":"13.83"},{"Metabolite":"Adenosine 5'-phosphosulfate","Ave m/z":"426.0152","Ave CorMT":"15.56"},{"Metabolite":"Adenosine 3',5'-diphosphate","Ave m/z":"426.0243","Ave CorMT":"13.02"},{"Metabolite":"ADP","Ave m/z":"426.0246","Ave CorMT":"14.76"},{"Metabolite":"IDP","Ave m/z":"427.0081","Ave CorMT":"14.56"},{"Metabolite":"Folate","Ave m/z":"440.1351","Ave CorMT":"15.56"},{"Metabolite":"GDP","Ave m/z":"442.0186","Ave CorMT":"15.01"},{"Metabolite":"Adenylosuccinate","Ave m/z":"462.0698","Ave CorMT":"12.85"},{"Metabolite":"Glycocholate","Ave m/z":"464.3048","Ave CorMT":"27.59"},{"Metabolite":"dCTP","Ave m/z":"465.9843","Ave CorMT":"13.57"},{"Metabolite":"dUTP","Ave m/z":"466.9686","Ave CorMT":"13.49"},{"Metabolite":"dTTP","Ave m/z":"480.9846","Ave CorMT":"13.79"},{"Metabolite":"CTP","Ave m/z":"481.9799","Ave CorMT":"13.68"},{"Metabolite":"UTP","Ave m/z":"482.9638","Ave CorMT":"13.54"},{"Metabolite":"dATP","Ave m/z":"489.9963","Ave CorMT":"14.10"},{"Metabolite":"dITP","Ave m/z":"490.9797","Ave CorMT":"13.96"},{"Metabolite":"ATP","Ave m/z":"505.9911","Ave CorMT":"14.09"},{"Metabolite":"dGTP","Ave m/z":"505.9910","Ave CorMT":"14.33"},{"Metabolite":"ITP","Ave m/z":"506.9748","Ave CorMT":"13.94"},{"Metabolite":"Taurocholate","Ave m/z":"514.2870","Ave CorMT":"27.56"},{"Metabolite":"GTP","Ave m/z":"521.9859","Ave CorMT":"14.37"},{"Metabolite":"XTP","Ave m/z":"522.9701","Ave CorMT":"12.49"},{"Metabolite":"CDP-choline","Ave m/z":"547.1251","Ave CorMT":"26.46"},{"Metabolite":"ADP-ribose","Ave m/z":"558.0673","Ave CorMT":"18.53"},{"Metabolite":"TDP-glucose","Ave m/z":"563.0702","Ave CorMT":"18.48"},{"Metabolite":"UDP-glucose","Ave m/z":"565.0504","Ave CorMT":"18.23"},{"Metabolite":"UDP-glucuronate","Ave m/z":"579.0294","Ave CorMT":"14.65"},{"Metabolite":"ADP-glucose","Ave m/z":"588.0788","Ave CorMT":"18.96"},{"Metabolite":"GDP-mannose","Ave m/z":"604.0732","Ave CorMT":"19.17"},{"Metabolite":"UDP-N-acetylglucosamine","Ave m/z":"606.0771","Ave CorMT":"18.64"},{"Metabolite":"CMP-N-acetylneuraminate","Ave m/z":"613.1423","Ave CorMT":"19.51"},{"Metabolite":"NAD+","Ave m/z":"662.1037","Ave CorMT":"28.47"},{"Metabolite":"Deamido-NAD+","Ave m/z":"663.0900","Ave CorMT":"18.99"},{"Metabolite":"NADH","Ave m/z":"664.1170","Ave CorMT":"19.41"},{"Metabolite":"NADP+","Ave m/z":"742.0711","Ave CorMT":"16.63"},{"Metabolite":"FAD","Ave m/z":"784.1531","Ave CorMT":"20.48"}]
}

}