{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002354","ANALYSIS_ID":"AN003842","VERSION":"1","CREATED_ON":"November 22, 2022, 5:53 am"},

"PROJECT":{"PROJECT_TITLE":"Combination of TP-252 and Naproxen elicit tumor protective Eicosanoid changes.","PROJECT_SUMMARY":"Comprehensive analysis of the lipidomic changes resulting from feeding with a over EPA analogue alone, and in combination with the NSAID naproxen.","INSTITUTE":"UConn Health","DEPARTMENT":"Center for Molecular Oncology","LABORATORY":"Rosenberg Laboratory","LAST_NAME":"Beach","FIRST_NAME":"Ryan","ADDRESS":"263 Farmington Avenue, Farmington, Connecticut, 06030, USA","EMAIL":"rbeach@uchc.edu","PHONE":"860-679-8703","FUNDING_SOURCE":"NCI PREVENT funding"},

"STUDY":{"STUDY_TITLE":"Combination of TP-252 and Naproxen elicit tumor protective Eicosanoid changes.","STUDY_SUMMARY":"Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States. Patients with the genetic disorder Familial Adenomatous Polyposis (FAP) develop hundreds to thousands of polyps that unless removed by prophylactic colectomy will progress to CRC at an early age. Non-steroidal anti-inflammatory drugs (NSAIDs) and -3 marine polyunsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA), have been evaluated for their chemopreventive potential in delaying the onset of CRC in high-risk patients. In this study, we determined whether the NSAID, naproxen, alone or in combination with a chemically-stable form of EPA (TP-252), affects tumor formation in the ApcPirc rat model. When compared to control diet, animals fed naproxen or HD TP-252 had 66%, and 82% fewer tumors respectively. However, when fed a combination of naproxen and HD TP-252, animals exhibited a 95% reduction in tumor formation and a 98% reduction in tumor volume, respectively. To elucidate potential mechanisms of tumor protection, a comprehensive, targeted lipidomic analysis was performed on colonic mucosa to determine changes in eicosanoid metabolism. Animals receiving TP-252 alone or in combination with naproxen had significantly reduced mucosal levels of pro-inflammatory -6 eicosanoids (PGE2, 5-HETE, and 14,15-DiHETrE), along with a simultaneous increase in anti-inflammatory EPA-derived -3 eicosanoids. Our colonic mucosal lipidomic analysis also uncovered several potential pharmacodynamic (PD) lipid biomarkers, including resolvin E2, 9-HEPE, 12-HEPE and 18-HEPE, that were increased in both the tissue and plasma of rats receiving TP-252 and were significantly correlated with tumor protection. Further studies with this drug combination should be focused on dose optimization and the role of EPA-derived lipid mediators in CRC initiation and progression.","INSTITUTE":"UConn Health","LAST_NAME":"Beach","FIRST_NAME":"Ryan","ADDRESS":"263 Farmington Avenue, Farmington CT 06030","EMAIL":"rbeach@uchc.edu","PHONE":"860-679-8703"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Rattus norvegicus","TAXONOMY_ID":"10116","AGE_OR_AGE_RANGE":"26 weeks of age","WEIGHT_OR_WEIGHT_RANGE":"320-460 grams","GENDER":"Male","ANIMAL_ANIMAL_SUPPLIER":"RRRC (University of Missouri)","ANIMAL_HOUSING":"Center for Comparative Medicine UConn","ANIMAL_FEED":"Modified AIN-93G diet from Research Diets","ANIMAL_WATER":"ab libitum"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"2440",
"Sample ID":"TFA-T1",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T1.wiff"}
},
{
"Subject ID":"2443",
"Sample ID":"TFA-T2",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T2.wiff"}
},
{
"Subject ID":"2538",
"Sample ID":"TFA-T3",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T3.wiff"}
},
{
"Subject ID":"2547",
"Sample ID":"TFA-T4",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T4.wiff"}
},
{
"Subject ID":"3181",
"Sample ID":"TFA-T5",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T5.wiff"}
},
{
"Subject ID":"3183",
"Sample ID":"TFA-T6",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T6.wiff"}
},
{
"Subject ID":"2444",
"Sample ID":"TFA-T7",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T7.wiff"}
},
{
"Subject ID":"2445",
"Sample ID":"TFA-T8",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T8.wiff"}
},
{
"Subject ID":"2446",
"Sample ID":"TFA-T9",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T9.wiff"}
},
{
"Subject ID":"2336",
"Sample ID":"TFA-T10",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T10.wiff"}
},
{
"Subject ID":"2850",
"Sample ID":"TFA-T11",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T11.wiff"}
},
{
"Subject ID":"2853",
"Sample ID":"TFA-T12",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T12.wiff"}
},
{
"Subject ID":"2853",
"Sample ID":"TFA-T13",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T13.wiff"}
},
{
"Subject ID":"3099",
"Sample ID":"TFA-T14",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T14.wiff"}
},
{
"Subject ID":"2448",
"Sample ID":"TFA-T15",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T15.wiff"}
},
{
"Subject ID":"2449",
"Sample ID":"TFA-T16",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T16.wiff"}
},
{
"Subject ID":"2450",
"Sample ID":"TFA-T17",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T17.wiff"}
},
{
"Subject ID":"2901",
"Sample ID":"TFA-T18",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T18.wiff"}
},
{
"Subject ID":"2903",
"Sample ID":"TFA-T19",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T19.wiff"}
},
{
"Subject ID":"3020",
"Sample ID":"TFA-T20",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T20.wiff"}
},
{
"Subject ID":"3021",
"Sample ID":"TFA-T21",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T21.wiff"}
},
{
"Subject ID":"2451",
"Sample ID":"TFA-T22",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T22.wiff"}
},
{
"Subject ID":"2453",
"Sample ID":"TFA-T23",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T23.wiff"}
},
{
"Subject ID":"2454",
"Sample ID":"TFA-T24",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T24.wiff"}
},
{
"Subject ID":"2884",
"Sample ID":"TFA-T25",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T25.wiff"}
},
{
"Subject ID":"2885",
"Sample ID":"TFA-T26",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T26.wiff"}
},
{
"Subject ID":"2271",
"Sample ID":"TFA-T27",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T27.wiff"}
},
{
"Subject ID":"2282",
"Sample ID":"TFA-T28",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T28.wiff"}
},
{
"Subject ID":"2344",
"Sample ID":"TFA-T29",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T29.wiff"}
},
{
"Subject ID":"2458",
"Sample ID":"TFA-T30",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T30.wiff"}
},
{
"Subject ID":"2460",
"Sample ID":"TFA-T31",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T31.wiff"}
},
{
"Subject ID":"2463",
"Sample ID":"TFA-T32",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T32.wiff"}
},
{
"Subject ID":"2878",
"Sample ID":"TFA-T33",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T33.wiff"}
},
{
"Subject ID":"2879",
"Sample ID":"TFA-T34",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T34.wiff"}
},
{
"Subject ID":"2883",
"Sample ID":"TFA-T35",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T35.wiff"}
},
{
"Subject ID":"2386",
"Sample ID":"TFA-T36",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T36.wiff"}
},
{
"Subject ID":"2743",
"Sample ID":"TFA-T37",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T37.wiff"}
},
{
"Subject ID":"2747",
"Sample ID":"TFA-T38",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T38.wiff"}
},
{
"Subject ID":"2899",
"Sample ID":"TFA-T39",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T39.wiff"}
},
{
"Subject ID":"2900",
"Sample ID":"TFA-T40",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T40.wiff"}
},
{
"Subject ID":"3029",
"Sample ID":"TFA-T41",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T41.wiff"}
},
{
"Subject ID":"3030",
"Sample ID":"TFA-T42",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T42.wiff"}
},
{
"Subject ID":"2738",
"Sample ID":"TFA-T43",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T43.wiff"}
},
{
"Subject ID":"2741",
"Sample ID":"TFA-T44",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T44.wiff"}
},
{
"Subject ID":"2847",
"Sample ID":"TFA-T45",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T45.wiff"}
},
{
"Subject ID":"2852",
"Sample ID":"TFA-T46",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T46.wiff"}
},
{
"Subject ID":"2854",
"Sample ID":"TFA-T47",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T47.wiff"}
},
{
"Subject ID":"3024",
"Sample ID":"TFA-T48",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T48.wiff"}
},
{
"Subject ID":"2385",
"Sample ID":"TFA-T49",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T49.wiff"}
},
{
"Subject ID":"3102",
"Sample ID":"TFA-T50",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T50.wiff"}
},
{
"Subject ID":"3104",
"Sample ID":"TFA-T51",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T51.wiff"}
},
{
"Subject ID":"2744",
"Sample ID":"TFA-T52",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T52.wiff"}
},
{
"Subject ID":"2745",
"Sample ID":"TFA-T53",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T53.wiff"}
},
{
"Subject ID":"2844",
"Sample ID":"TFA-T54",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T54.wiff"}
},
{
"Subject ID":"2845",
"Sample ID":"TFA-T55",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T55.wiff"}
},
{
"Subject ID":"2846",
"Sample ID":"TFA-T56",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-T56.wiff"}
},
{
"Subject ID":"2440",
"Sample ID":"EicoT1",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT1.wiff"}
},
{
"Subject ID":"2443",
"Sample ID":"EicoT2",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT2.wiff"}
},
{
"Subject ID":"2538",
"Sample ID":"EicoT3",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT3.wiff"}
},
{
"Subject ID":"2547",
"Sample ID":"EicoT4",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT4.wiff"}
},
{
"Subject ID":"3181",
"Sample ID":"EicoT5",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT5.wiff"}
},
{
"Subject ID":"3183",
"Sample ID":"EicoT6",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT6.wiff"}
},
{
"Subject ID":"2444",
"Sample ID":"EicoT7",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT7.wiff"}
},
{
"Subject ID":"2445",
"Sample ID":"EicoT8",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT8.wiff"}
},
{
"Subject ID":"2446",
"Sample ID":"EicoT9",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT9.wiff"}
},
{
"Subject ID":"2336",
"Sample ID":"EicoT10",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT10.wiff"}
},
{
"Subject ID":"2850",
"Sample ID":"EicoT11",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT11.wiff"}
},
{
"Subject ID":"2853",
"Sample ID":"EicoT12",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT12.wiff"}
},
{
"Subject ID":"2853",
"Sample ID":"EicoT13",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT13.wiff"}
},
{
"Subject ID":"3099",
"Sample ID":"EicoT14",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT14.wiff"}
},
{
"Subject ID":"2448",
"Sample ID":"EicoT15",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT15.wiff"}
},
{
"Subject ID":"2449",
"Sample ID":"EicoT16",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT16.wiff"}
},
{
"Subject ID":"2450",
"Sample ID":"EicoT17",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT17.wiff"}
},
{
"Subject ID":"2901",
"Sample ID":"EicoT18",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT18.wiff"}
},
{
"Subject ID":"2903",
"Sample ID":"EicoT19",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT19.wiff"}
},
{
"Subject ID":"3020",
"Sample ID":"EicoT20",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT20.wiff"}
},
{
"Subject ID":"3021",
"Sample ID":"EicoT21",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT21.wiff"}
},
{
"Subject ID":"2451",
"Sample ID":"EicoT22",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT22.wiff"}
},
{
"Subject ID":"2453",
"Sample ID":"EicoT23",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT23.wiff"}
},
{
"Subject ID":"2454",
"Sample ID":"EicoT24",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT24.wiff"}
},
{
"Subject ID":"2884",
"Sample ID":"EicoT25",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT25.wiff"}
},
{
"Subject ID":"2885",
"Sample ID":"EicoT26",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT26.wiff"}
},
{
"Subject ID":"2271",
"Sample ID":"EicoT27",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT27.wiff"}
},
{
"Subject ID":"2282",
"Sample ID":"EicoT28",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT28.wiff"}
},
{
"Subject ID":"2344",
"Sample ID":"EicoT29",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT29.wiff"}
},
{
"Subject ID":"2458",
"Sample ID":"EicoT30",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT30.wiff"}
},
{
"Subject ID":"2460",
"Sample ID":"EicoT31",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT31.wiff"}
},
{
"Subject ID":"2463",
"Sample ID":"EicoT32",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT32.wiff"}
},
{
"Subject ID":"2878",
"Sample ID":"EicoT33",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT33.wiff"}
},
{
"Subject ID":"2879",
"Sample ID":"EicoT34",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT34.wiff"}
},
{
"Subject ID":"2883",
"Sample ID":"EicoT35",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT35.wiff"}
},
{
"Subject ID":"2386",
"Sample ID":"EicoT36",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT36.wiff"}
},
{
"Subject ID":"2743",
"Sample ID":"EicoT37",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT37.wiff"}
},
{
"Subject ID":"2747",
"Sample ID":"EicoT38",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT38.wiff"}
},
{
"Subject ID":"2899",
"Sample ID":"EicoT39",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT39.wiff"}
},
{
"Subject ID":"2900",
"Sample ID":"EicoT40",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT40.wiff"}
},
{
"Subject ID":"3029",
"Sample ID":"EicoT41",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT41.wiff"}
},
{
"Subject ID":"3030",
"Sample ID":"EicoT42",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT42.wiff"}
},
{
"Subject ID":"2738",
"Sample ID":"EicoT43",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT43.wiff"}
},
{
"Subject ID":"2741",
"Sample ID":"EicoT44",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT44.wiff"}
},
{
"Subject ID":"2847",
"Sample ID":"EicoT45",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT45.wiff"}
},
{
"Subject ID":"2852",
"Sample ID":"EicoT46",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT46.wiff"}
},
{
"Subject ID":"2854",
"Sample ID":"EicoT47",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT47.wiff"}
},
{
"Subject ID":"3024",
"Sample ID":"EicoT48",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT48.wiff"}
},
{
"Subject ID":"2385",
"Sample ID":"EicoT49",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT49.wiff"}
},
{
"Subject ID":"3102",
"Sample ID":"EicoT50",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT50.wiff"}
},
{
"Subject ID":"3104",
"Sample ID":"EicoT51",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT51.wiff"}
},
{
"Subject ID":"2744",
"Sample ID":"EicoT52",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT52.wiff"}
},
{
"Subject ID":"2745",
"Sample ID":"EicoT53",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT53.wiff"}
},
{
"Subject ID":"2844",
"Sample ID":"EicoT54",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT54.wiff"}
},
{
"Subject ID":"2845",
"Sample ID":"EicoT55",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT55.wiff"}
},
{
"Subject ID":"2846",
"Sample ID":"EicoT56",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Tumor-adjacent normal colon"},
"Additional sample data":{"RAW_FILE_NAME":"EicoT56.wiff"}
},
{
"Subject ID":"2538",
"Sample ID":"TFA-P1",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P1.wiff"}
},
{
"Subject ID":"2547",
"Sample ID":"TFA-P2",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P2.wiff"}
},
{
"Subject ID":"2442",
"Sample ID":"TFA-P3",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P3.wiff"}
},
{
"Subject ID":"2440",
"Sample ID":"TFA-P4",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P4.wiff"}
},
{
"Subject ID":"3183",
"Sample ID":"TFA-P5",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P5.wiff"}
},
{
"Subject ID":"3181",
"Sample ID":"TFA-P6",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P6.wiff"}
},
{
"Subject ID":"3190",
"Sample ID":"TFA-P7",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P7.wiff"}
},
{
"Subject ID":"2165",
"Sample ID":"TFA-P8",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P8.wiff"}
},
{
"Subject ID":"2167",
"Sample ID":"TFA-P9",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P9.wiff"}
},
{
"Subject ID":"2168",
"Sample ID":"TFA-P10",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P10.wiff"}
},
{
"Subject ID":"2333",
"Sample ID":"TFA-P11",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P11.wiff"}
},
{
"Subject ID":"2444",
"Sample ID":"TFA-P12",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P12.wiff"}
},
{
"Subject ID":"2445",
"Sample ID":"TFA-P13",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P13.wiff"}
},
{
"Subject ID":"2853",
"Sample ID":"TFA-P14",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P14.wiff"}
},
{
"Subject ID":"2264",
"Sample ID":"TFA-P15",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P15.wiff"}
},
{
"Subject ID":"2267",
"Sample ID":"TFA-P16",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P16.wiff"}
},
{
"Subject ID":"2265",
"Sample ID":"TFA-P17",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P17.wiff"}
},
{
"Subject ID":"2448",
"Sample ID":"TFA-P18",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P18.wiff"}
},
{
"Subject ID":"2449",
"Sample ID":"TFA-P19",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P19.wiff"}
},
{
"Subject ID":"2450",
"Sample ID":"TFA-P20",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P20.wiff"}
},
{
"Subject ID":"3020",
"Sample ID":"TFA-P21",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P21.wiff"}
},
{
"Subject ID":"2170",
"Sample ID":"TFA-P22",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P22.wiff"}
},
{
"Subject ID":"2169",
"Sample ID":"TFA-P23",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P23.wiff"}
},
{
"Subject ID":"2271",
"Sample ID":"TFA-P24",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P24.wiff"}
},
{
"Subject ID":"2451",
"Sample ID":"TFA-P25",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P25.wiff"}
},
{
"Subject ID":"2453",
"Sample ID":"TFA-P26",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P26.wiff"}
},
{
"Subject ID":"2284",
"Sample ID":"TFA-P27",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P27.wiff"}
},
{
"Subject ID":"2282",
"Sample ID":"TFA-P28",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P28.wiff"}
},
{
"Subject ID":"2344",
"Sample ID":"TFA-P29",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P29.wiff"}
},
{
"Subject ID":"2458",
"Sample ID":"TFA-P30",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P30.wiff"}
},
{
"Subject ID":"2352",
"Sample ID":"TFA-P31",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P31.wiff"}
},
{
"Subject ID":"2460",
"Sample ID":"TFA-P32",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P32.wiff"}
},
{
"Subject ID":"2879",
"Sample ID":"TFA-P33",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P33.wiff"}
},
{
"Subject ID":"2883",
"Sample ID":"TFA-P34",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P34.wiff"}
},
{
"Subject ID":"2463",
"Sample ID":"TFA-P35",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P35.wiff"}
},
{
"Subject ID":"2171",
"Sample ID":"TFA-P36",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P36.wiff"}
},
{
"Subject ID":"2174",
"Sample ID":"TFA-P37",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P37.wiff"}
},
{
"Subject ID":"2175",
"Sample ID":"TFA-P38",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P38.wiff"}
},
{
"Subject ID":"2386",
"Sample ID":"TFA-P39",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P39.wiff"}
},
{
"Subject ID":"2387",
"Sample ID":"TFA-P40",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P40.wiff"}
},
{
"Subject ID":"2900",
"Sample ID":"TFA-P41",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P41.wiff"}
},
{
"Subject ID":"2743",
"Sample ID":"TFA-P42",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P42.wiff"}
},
{
"Subject ID":"2385",
"Sample ID":"TFA-P43",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P43.wiff"}
},
{
"Subject ID":"2394",
"Sample ID":"TFA-P44",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P44.wiff"}
},
{
"Subject ID":"2398",
"Sample ID":"TFA-P45",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P45.wiff"}
},
{
"Subject ID":"2738",
"Sample ID":"TFA-P46",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P46.wiff"}
},
{
"Subject ID":"2741",
"Sample ID":"TFA-P47",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P47.wiff"}
},
{
"Subject ID":"2847",
"Sample ID":"TFA-P48",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P48.wiff"}
},
{
"Subject ID":"2852",
"Sample ID":"TFA-P49",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P49.wiff"}
},
{
"Subject ID":"2177",
"Sample ID":"TFA-P50",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P50.wiff"}
},
{
"Subject ID":"2180",
"Sample ID":"TFA-P51",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P51.wiff"}
},
{
"Subject ID":"2384",
"Sample ID":"TFA-P52",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P52.wiff"}
},
{
"Subject ID":"2389",
"Sample ID":"TFA-P53",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P53.wiff"}
},
{
"Subject ID":"2391",
"Sample ID":"TFA-P54",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P54.wiff"}
},
{
"Subject ID":"2744",
"Sample ID":"TFA-P55",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P55.wiff"}
},
{
"Subject ID":"2745",
"Sample ID":"TFA-P56",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Fatty Acid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"TFA-P56.wiff"}
},
{
"Subject ID":"2538",
"Sample ID":"EicoP1",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP1.wiff"}
},
{
"Subject ID":"2547",
"Sample ID":"EicoP2",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP2.wiff"}
},
{
"Subject ID":"2442",
"Sample ID":"EicoP3",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP3.wiff"}
},
{
"Subject ID":"2440",
"Sample ID":"EicoP4",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP4.wiff"}
},
{
"Subject ID":"3183",
"Sample ID":"EicoP5",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP5.wiff"}
},
{
"Subject ID":"3181",
"Sample ID":"EicoP6",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP6.wiff"}
},
{
"Subject ID":"3190",
"Sample ID":"EicoP7",
"Factors":{"Genotype":"F344 Pirc","Treatment":"AIN-93G (control)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP7.wiff"}
},
{
"Subject ID":"2165",
"Sample ID":"EicoP8",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP8.wiff"}
},
{
"Subject ID":"2167",
"Sample ID":"EicoP9",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP9.wiff"}
},
{
"Subject ID":"2168",
"Sample ID":"EicoP10",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP10.wiff"}
},
{
"Subject ID":"2333",
"Sample ID":"EicoP11",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP11.wiff"}
},
{
"Subject ID":"2444",
"Sample ID":"EicoP12",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP12.wiff"}
},
{
"Subject ID":"2445",
"Sample ID":"EicoP13",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP13.wiff"}
},
{
"Subject ID":"2853",
"Sample ID":"EicoP14",
"Factors":{"Genotype":"F344 Pirc","Treatment":"200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP14.wiff"}
},
{
"Subject ID":"2264",
"Sample ID":"EicoP15",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP15.wiff"}
},
{
"Subject ID":"2267",
"Sample ID":"EicoP16",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP16.wiff"}
},
{
"Subject ID":"2265",
"Sample ID":"EicoP17",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP17.wiff"}
},
{
"Subject ID":"2448",
"Sample ID":"EicoP18",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP18.wiff"}
},
{
"Subject ID":"2449",
"Sample ID":"EicoP19",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP19.wiff"}
},
{
"Subject ID":"2450",
"Sample ID":"EicoP20",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP20.wiff"}
},
{
"Subject ID":"3020",
"Sample ID":"EicoP21",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP21.wiff"}
},
{
"Subject ID":"2170",
"Sample ID":"EicoP22",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP22.wiff"}
},
{
"Subject ID":"2169",
"Sample ID":"EicoP23",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP23.wiff"}
},
{
"Subject ID":"2271",
"Sample ID":"EicoP24",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP24.wiff"}
},
{
"Subject ID":"2451",
"Sample ID":"EicoP25",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP25.wiff"}
},
{
"Subject ID":"2453",
"Sample ID":"EicoP26",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP26.wiff"}
},
{
"Subject ID":"2284",
"Sample ID":"EicoP27",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP27.wiff"}
},
{
"Subject ID":"2282",
"Sample ID":"EicoP28",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP28.wiff"}
},
{
"Subject ID":"2344",
"Sample ID":"EicoP29",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP29.wiff"}
},
{
"Subject ID":"2458",
"Sample ID":"EicoP30",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP30.wiff"}
},
{
"Subject ID":"2352",
"Sample ID":"EicoP31",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP31.wiff"}
},
{
"Subject ID":"2460",
"Sample ID":"EicoP32",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP32.wiff"}
},
{
"Subject ID":"2879",
"Sample ID":"EicoP33",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP33.wiff"}
},
{
"Subject ID":"2883",
"Sample ID":"EicoP34",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP34.wiff"}
},
{
"Subject ID":"2463",
"Sample ID":"EicoP35",
"Factors":{"Genotype":"F344 Pirc","Treatment":"LD TP-252 (1.5% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP35.wiff"}
},
{
"Subject ID":"2171",
"Sample ID":"EicoP36",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP36.wiff"}
},
{
"Subject ID":"2174",
"Sample ID":"EicoP37",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP37.wiff"}
},
{
"Subject ID":"2175",
"Sample ID":"EicoP38",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP38.wiff"}
},
{
"Subject ID":"2386",
"Sample ID":"EicoP39",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP39.wiff"}
},
{
"Subject ID":"2387",
"Sample ID":"EicoP40",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP40.wiff"}
},
{
"Subject ID":"2900",
"Sample ID":"EicoP41",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP41.wiff"}
},
{
"Subject ID":"2743",
"Sample ID":"EicoP42",
"Factors":{"Genotype":"F344 Pirc","Treatment":"HD TP-252 (3% EPA) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP42.wiff"}
},
{
"Subject ID":"2385",
"Sample ID":"EicoP43",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP43.wiff"}
},
{
"Subject ID":"2394",
"Sample ID":"EicoP44",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP44.wiff"}
},
{
"Subject ID":"2398",
"Sample ID":"EicoP45",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP45.wiff"}
},
{
"Subject ID":"2738",
"Sample ID":"EicoP46",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP46.wiff"}
},
{
"Subject ID":"2741",
"Sample ID":"EicoP47",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP47.wiff"}
},
{
"Subject ID":"2847",
"Sample ID":"EicoP48",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP48.wiff"}
},
{
"Subject ID":"2852",
"Sample ID":"EicoP49",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2% EPA)","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP49.wiff"}
},
{
"Subject ID":"2177",
"Sample ID":"EicoP50",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP50.wiff"}
},
{
"Subject ID":"2180",
"Sample ID":"EicoP51",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP51.wiff"}
},
{
"Subject ID":"2384",
"Sample ID":"EicoP52",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP52.wiff"}
},
{
"Subject ID":"2389",
"Sample ID":"EicoP53",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP53.wiff"}
},
{
"Subject ID":"2391",
"Sample ID":"EicoP54",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP54.wiff"}
},
{
"Subject ID":"2744",
"Sample ID":"EicoP55",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP55.wiff"}
},
{
"Subject ID":"2745",
"Sample ID":"EicoP56",
"Factors":{"Genotype":"F344 Pirc","Treatment":"EPA-FFA (2%) + 200 ppm Naproxen","Metabolite":"Eicosanoid","Tissue":"Plasma"},
"Additional sample data":{"RAW_FILE_NAME":"EicoP56.wiff"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Animals were sacrificed by CO2 narcosis, and large intestines were excised, washed with ice-cold PBS, and laid flat on filter paper. Tumor-adjacent full-thickness colon segments were flash-frozen in liquid Nitrogen and stored at -80C until analysis. Blood was collected via cardiac puncture and put in lithium heparin tubes on ice. Samples were centrifuged at 2,000 g for 20 minutes, and supernatant (plasma) was collected and stored at -80C until analysis.","SAMPLE_TYPE":"Blood (Plasma) and Large Intestine"},

"TREATMENT":{"TREATMENT_SUMMARY":"Rats were fed two doses of TP-252 equivalent to consuming 1.3 and 2.6 g/kg/day for LD TP-252 and HD TP-252, respectively. Alternatively, rats were also fed a diet containing 2% EPA-FFA in their diet (equivalent to 1.14 g/kg/day of EPA). In groups receiving naproxen, the dose of naproxen was 11.4 mg/kg/day, or roughly 4 mg/rat/day. These treatment groups were carried out for the 20 weeks, and then animals were sacrificed and tissue collected and analyzed."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Samples (0.85 ml) were spiked with 5 ng each (in 150 μl methanol) of 15(S)-HETE-d8,14(15)-EpETrE-d11, Resolvin D2-d5, Leukotriene B4-d4, and Prostaglandin E1-d4 as internal standards for recovery and quantitation and mixed thoroughly. The samples were then extracted for PUFA metabolites using C18 extraction columns as described earlier [1-4]. Briefly, the internal standard spiked samples were applied to conditioned C18 cartridges, washed with 15% methanol in water followed by hexane and dried under vacuum. The cartridges were eluted with 0.5 ml methanol. The eluate was dried under a gentle stream of nitrogen. The residue was redissolved in 50 μl methanol-25 mM aqueous ammonium acetate (1:1) and subjected to LC-MS analysis.","SAMPLEPREP_PROTOCOL_FILENAME":"Methods of Eicosanoid Detection.pdf"},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"HPLC was performed on a Prominence XR system (Shimadzu) using Luna C18 (3μ, 2.1x150 mm) column. The mobile phase consisted of a gradient between A: methanol-water-acetonitrile (10:85:5 v/v) and B: methanol-water-acetonitrile (90:5:5 v/v), both containing 0.1% ammonium acetate. The gradient program with respect to the composition of B was as follows: 0-1 min, 50%; 1-8 min, 50-80%; 8-15 min, 80-95%; and 15-17 min, 95%. The flow rate was 0.2 ml/min. The HPLC eluate was directly introduced to ESI source of QTRAP5500 mass analyzer (ABSCIEX) in the negative ion mode with following conditions: Curtain gas: 35 psi, GS1: 35 psi, GS2: 65 psi, Temperature: 600 ˚C, Ion Spray Voltage: -1500 V, Collision gas: low, Declustering Potential: -60 V, and Entrance Potential: -7 V. The eluate was monitored by Multiple Reaction Monitoring method to detect unique molecular ion – daughter ion combinations for each of the lipid mediators using a scheduled MRM around the expected retention time for each compound. Optimized Collisional Energies (18 – 35 eV) and Collision Cell Exit Potentials (7 – 10 V) were used for each MRM transition. Spectra of each peak detected in the scheduled MRM were recorded using Enhanced Product Ion scan to confirm the structural identity. The data was collected using Analyst 1.6.2 software and the MRM transition chromatograms were quantitated by MultiQuant software (both from ABSCIEX). The internal standard signals in each chromatogram were used for normalization, recovery, as well as relative quantitation of each analyte.","CHROMATOGRAPHY_TYPE":"None (Direct infusion)","INSTRUMENT_NAME":"Prominence XR","COLUMN_NAME":"Targa C8, 2x10 mm, 5μ","FLOW_RATE":"0.25ml/min"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"ABI Sciex 5500 QTrap","INSTRUMENT_TYPE":"QTRAP","MS_TYPE":"ESI","ION_MODE":"NEGATIVE","MS_COMMENTS":"Mass spectra for each detected lipid metabolite were recorded using the enhanced production feature to verify the identity of the detected peak. Data were collected and quantified using Analyst 1.6.2 (SCIEX) and MultiQuant (SCIEX) software, respectively. Correction for recovery efficiencies and relative quantitation of each analyte were performed using signals from each chromatogram corresponding to the spiked-in internal standards. Under standardized conditions of liquid chromatography-mass spectrometry quantitation, the detection limits for the eicosanoids are 1–2 pg on the column and the limit of quantitation is 5 pg at a signal-to-noise ratio of 3."},

"MS_METABOLITE_DATA":{
"Units":"mg/g tissue",

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"Metabolites":[{"Metabolite":"Dodecanoic acid","KEGG ID":"C02679","PubChem ID":"3893","quantified m/z":"200"},{"Metabolite":"Myristic acid","KEGG ID":"C06242","PubChem ID":"11005","quantified m/z":"228"},{"Metabolite":"Pentadecanoic acid","KEGG ID":"C16537","PubChem ID":"13849","quantified m/z":"242"},{"Metabolite":"Palmitoleic acid","KEGG ID":"C08362","PubChem ID":"445638","quantified m/z":"254"},{"Metabolite":"Palmitic acid","KEGG ID":"C00249","PubChem ID":"985","quantified m/z":"256"},{"Metabolite":"Heptadecenoic acid","KEGG ID":"C16536","PubChem ID":"5312440","quantified m/z":"268"},{"Metabolite":"Heptadecanoic acid","KEGG ID":"","PubChem ID":"10465","quantified m/z":"270"},{"Metabolite":"Octadecatetraenoic acid (Stearidonic acid)","KEGG ID":"C16300","PubChem ID":"5312508","quantified m/z":"276"},{"Metabolite":"Linolenic acid (alpha)","KEGG ID":"C06427","PubChem ID":"8662","quantified m/z":"278"},{"Metabolite":"Linoleic acid","KEGG ID":"C01595","PubChem ID":"5280450","quantified m/z":"280"},{"Metabolite":"Oleic acid","KEGG ID":"C00712","PubChem ID":"3978","quantified m/z":"282"},{"Metabolite":"Stearic acid","KEGG ID":"C01530","PubChem ID":"4692","quantified m/z":"284"},{"Metabolite":"Eicosapentaenoic acid","KEGG ID":"C06428","PubChem ID":"446284","quantified m/z":"302"},{"Metabolite":"Arachidonic acid","KEGG ID":"C00219","PubChem ID":"444899","quantified m/z":"304"},{"Metabolite":"Dihomo-g-linolenic acid","KEGG ID":"C03242","PubChem ID":"53486","quantified m/z":"306"},{"Metabolite":"Mead acid","KEGG ID":"C21938","PubChem ID":"5312531","quantified m/z":"306"},{"Metabolite":"Eicosadienoic acid","KEGG ID":"C16525","PubChem ID":"5282805","quantified m/z":"308"},{"Metabolite":"Eicosenoic acid","KEGG ID":"C16526","PubChem ID":"5282768","quantified m/z":"310"},{"Metabolite":"Arachidic acid","KEGG ID":"C06425","PubChem ID":"10467","quantified m/z":"312"},{"Metabolite":"Docosahexaenoic acid","KEGG ID":"C06429","PubChem ID":"445580","quantified m/z":"328"},{"Metabolite":"Docosapentaenoic acid (n-3)","KEGG ID":"C16513","PubChem ID":"5497182","quantified m/z":"330"},{"Metabolite":"Docosapentaenoic acid (n-6)","KEGG ID":"","PubChem ID":"5282848","quantified m/z":"330"},{"Metabolite":"Docosatetraenoic acid","KEGG ID":"C16527","PubChem ID":"5497181","quantified m/z":"332"},{"Metabolite":"Docosatrienoic acid","KEGG ID":"C16534","PubChem ID":"5312557","quantified m/z":"334"},{"Metabolite":"Docosadienoic acid","KEGG ID":"C16533","PubChem ID":"51090862","quantified m/z":"336"},{"Metabolite":"Docosenoic acid","KEGG ID":"C08316","PubChem ID":"10514","quantified m/z":"338"},{"Metabolite":"Docosanoic acid (Behenic acid)","KEGG ID":"C08281","PubChem ID":"10479","quantified m/z":"340"},{"Metabolite":"Nervonic acid","KEGG ID":"C08323","PubChem ID":"10521","quantified m/z":"366"},{"Metabolite":"Lignoceric acid","KEGG ID":"C08320","PubChem ID":"10518","quantified m/z":"368"},{"Metabolite":"Hexacosenoic acid","KEGG ID":"C17278","PubChem ID":"5282775","quantified m/z":"394"},{"Metabolite":"Hexacosanoic acid","KEGG ID":"C21931","PubChem ID":"10469","quantified m/z":"396"}]
}

}