{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002377","ANALYSIS_ID":"AN003873","VERSION":"1","CREATED_ON":"December 1, 2022, 9:57 am"},

"PROJECT":{"PROJECT_TITLE":"Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups","PROJECT_SUMMARY":"Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here we demonstrate that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by the phospholipase/lysophospholipase PNPLA8-PNPLA7 axis enables endogenous choline stored in hepatic PC to be utilized in methyl metabolism. PNPLA7-deficient mice show marked decreases in hepatic GPC, choline, and several metabolites related to the methionine cycle, accompanied by various signs of methionine insufficiency including growth retardation, hypoglycemia, hypolipidemia, increased energy consumption, reduced adiposity, increased FGF21, and an altered histone/DNA methylation landscape. Moreover, PNPLA8-deficient mice recapitulate most of these phenotypes. In contrast to wild-type mice fed a methionine/choline-deficient diet, both knockout strains display a decreased hepatic triglyceride likely via reductions of lipogenesis and GPC-derived glycerol flux. Collectively, our findings highlight the biological importance of phospholipid catabolism driven by PNPLA8/PNPLA7 in methyl group flux and triglyceride synthesis in the liver.","INSTITUTE":"Tokyo Metropolitan Institute of Medical Science","LAST_NAME":"Hirabayashi","FIRST_NAME":"Tetsuya","ADDRESS":"2-6-1 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan","EMAIL":"hirabayashi-tt@igakuken.or.jp","PHONE":"+81-3-5316-3100"},

"STUDY":{"STUDY_TITLE":"Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups (Pnpla7-knockout)","STUDY_SUMMARY":"Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here we demonstrate that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by the phospholipase/lysophospholipase PNPLA8-PNPLA7 axis enables endogenous choline stored in hepatic PC to be utilized in methyl metabolism. PNPLA7-deficient mice show marked decreases in hepatic GPC, choline, and several metabolites related to the methionine cycle, accompanied by various signs of methionine insufficiency including growth retardation, hypoglycemia, hypolipidemia, increased energy consumption, reduced adiposity, increased FGF21, and an altered histone/DNA methylation landscape. Moreover, PNPLA8-deficient mice recapitulate most of these phenotypes. In contrast to wild-type mice fed a methionine/choline-deficient diet, both knockout strains display a decreased hepatic triglyceride likely via reductions of lipogenesis and GPC-derived glycerol flux. Collectively, our findings highlight the biological importance of phospholipid catabolism driven by PNPLA8/PNPLA7 in methyl group flux and triglyceride synthesis in the liver.","INSTITUTE":"Tokyo Metropolitan Institute of Medical Science","LAST_NAME":"Hirabayashi","FIRST_NAME":"Tetsuya","ADDRESS":"2-6-1 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan","EMAIL":"hirabayashi-tt@igakuken.or.jp","PHONE":"+81-3-5316-3100"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090","GENOTYPE_STRAIN":"C57BL/6N","AGE_OR_AGE_RANGE":"6-weeks old"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"WT1",
"Factors":{"Genotype":"Wild-type"}
},
{
"Subject ID":"-",
"Sample ID":"WT2",
"Factors":{"Genotype":"Wild-type"}
},
{
"Subject ID":"-",
"Sample ID":"WT3",
"Factors":{"Genotype":"Wild-type"}
},
{
"Subject ID":"-",
"Sample ID":"WT4",
"Factors":{"Genotype":"Wild-type"}
},
{
"Subject ID":"-",
"Sample ID":"WT5",
"Factors":{"Genotype":"Wild-type"}
},
{
"Subject ID":"-",
"Sample ID":"WT6",
"Factors":{"Genotype":"Wild-type"}
},
{
"Subject ID":"-",
"Sample ID":"KO1",
"Factors":{"Genotype":"Pnpla7-knockout"}
},
{
"Subject ID":"-",
"Sample ID":"KO2",
"Factors":{"Genotype":"Pnpla7-knockout"}
},
{
"Subject ID":"-",
"Sample ID":"KO3",
"Factors":{"Genotype":"Pnpla7-knockout"}
},
{
"Subject ID":"-",
"Sample ID":"KO4",
"Factors":{"Genotype":"Pnpla7-knockout"}
},
{
"Subject ID":"-",
"Sample ID":"KO5",
"Factors":{"Genotype":"Pnpla7-knockout"}
},
{
"Subject ID":"-",
"Sample ID":"KO6",
"Factors":{"Genotype":"Pnpla7-knockout"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Mice were deeply anesthetized and perfused intracardially with saline containing 1 mM MOPS (pH 7.4). Liver was rapidly removed, frozen on liquid nitrogen and stored at –80°C until further processing.","SAMPLE_TYPE":"Liver","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"No treatment in this study."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Tissues with internal standards were homogenized with ice-cold methanol and extracted by the Bligh–Dyer method using chloroform and methanol to separate and recover the water-soluble fractions. The supernatant was filtered through a 5-kDa cut-off filter (Ultrafree-MC-PLHCC, Human Metabolome Technologies) at 9,100 × g for 2 h at 4 °C, dried in a centrifugal evaporator at 1,500 rpm at 1,000 Pa, and resuspended in 50 μl of ultrapure water before metabolome analysis."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"CE","INSTRUMENT_NAME":"Agilent 7100 CE","COLUMN_NAME":"Fused silica capillary i.d. 50 μm × 80 cm"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 6224 TOF","INSTRUMENT_TYPE":"Other","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"The spectrometer was scanned from m/z 50 to 1,000. Peaks were extracted using automatic integration software MasterHands (ver.2.16.0.15 Keio University). Putative metabolites were assigned based on the m/z value and migration time using Human Metabolomic Technologies’ standard library and known–unknown peak library. Peak areas were normalized to internal standards and sample amounts."},

"MS_METABOLITE_DATA":{
"Units":"nmol",

"Data":[{"Metabolite":"1-Methyladenosine","WT1":"1.17","WT2":"1.17","WT3":"0.77","WT4":"1.39","WT5":"1.08","KO1":"1.45","KO2":"1.47","KO3":"1.53","KO4":"1.69","KO5":"1.55"},{"Metabolite":"1-Methylhistamine","WT1":"0.61","WT2":"1.41","WT3":"1.05","WT4":"1.94","WT5":"0.67","KO1":"1.32","KO2":"0.80","KO3":"1.20","KO4":"0.69","KO5":"0.76"},{"Metabolite":"1-Methylnicotinamide","WT1":"11.82","WT2":"18.47","WT3":"14.61","WT4":"13.28","WT5":"13.84","KO1":"19.97","KO2":"5.83","KO3":"6.91","KO4":"13.61","KO5":"14.80"},{"Metabolite":"2,4-Diaminobutyrate","WT1":"2.40","WT2":"3.52","WT3":"1.38","WT4":"2.42","WT5":"3.71","KO1":"1.07","KO2":"1.17","KO3":"1.97","KO4":"1.62","KO5":"1.45"},{"Metabolite":"D-2-aminobutyrate","WT1":"146.59","WT2":"94.45","WT3":"69.64","WT4":"92.47","WT5":"119.73","KO1":"217.96","KO2":"87.39","KO3":"174.42","KO4":"188.13","KO5":"184.11"},{"Metabolite":"3-Aminoisobutyrate","WT1":"22.78","WT2":"11.09","WT3":"13.78","WT4":"12.34","WT5":"10.80","KO1":"16.42","KO2":"16.81","KO3":"13.56","KO4":"14.51","KO5":"14.21"},{"Metabolite":"3-Methylhistidine","WT1":"3.24","WT2":"2.97","WT3":"1.54","WT4":"1.89","WT5":"3.81","KO1":"2.57","KO2":"2.85","KO3":"3.26","KO4":"2.67","KO5":"3.00"},{"Metabolite":"5-Aminoimidazole-4-carboxamide ribotide","WT1":"3.35","WT2":"3.42","WT3":"4.10","WT4":"3.21","WT5":"2.55","KO1":"2.89","KO2":"3.42","KO3":"3.11","KO4":"3.33","KO5":"3.96"},{"Metabolite":"5-Aminolevulinate","WT1":"11.65","WT2":"9.64","WT3":"10.55","WT4":"10.00","WT5":"8.01","KO1":"6.57","KO2":"4.28","KO3":"8.77","KO4":"11.03","KO5":"8.58"},{"Metabolite":"5-Hydroxyindoleacetate","WT1":"1.89","WT2":"0.68","WT3":"1.62","WT4":"0.88","WT5":"1.47","KO1":"0.94","KO2":"N.D.","KO3":"0.66","KO4":"0.79","KO5":"0.39"},{"Metabolite":"5-Methyltetrahydrofolate","WT1":"20.73","WT2":"8.08","WT3":"5.00","WT4":"6.41","WT5":"31.76","KO1":"2.34","KO2":"1.83","KO3":"5.86","KO4":"3.31","KO5":"6.20"},{"Metabolite":"5-Methylthioadenosine","WT1":"7.91","WT2":"8.59","WT3":"15.76","WT4":"6.76","WT5":"6.77","KO1":"27.63","KO2":"3.11","KO3":"2.93","KO4":"6.80","KO5":"1.56"},{"Metabolite":"7,8-Dihydrobiopterin","WT1":"7.49","WT2":"9.31","WT3":"6.48","WT4":"9.87","WT5":"8.01","KO1":"9.06","KO2":"7.92","KO3":"8.61","KO4":"9.40","KO5":"9.45"},{"Metabolite":"Adenine","WT1":"8.53","WT2":"11.14","WT3":"6.63","WT4":"11.61","WT5":"11.73","KO1":"10.04","KO2":"8.35","KO3":"11.31","KO4":"10.06","KO5":"12.33"},{"Metabolite":"Adenosine","WT1":"146.46","WT2":"171.75","WT3":"106.67","WT4":"240.21","WT5":"159.42","KO1":"265.68","KO2":"118.55","KO3":"173.16","KO4":"217.52","KO5":"117.69"},{"Metabolite":"ADMA","WT1":"13.11","WT2":"4.66","WT3":"8.66","WT4":"7.93","WT5":"10.66","KO1":"3.17","KO2":"7.99","KO3":"6.71","KO4":"6.25","KO5":"9.65"},{"Metabolite":"Ala","WT1":"4440.49","WT2":"3186.85","WT3":"3787.94","WT4":"4982.90","WT5":"4649.72","KO1":"4901.84","KO2":"2710.51","KO3":"4836.44","KO4":"3711.94","KO5":"3187.41"},{"Metabolite":"Ala-Ala","WT1":"4.13","WT2":"4.87","WT3":"5.26","WT4":"3.73","WT5":"3.16","KO1":"3.76","KO2":"2.19","KO3":"3.01","KO4":"3.43","KO5":"1.55"},{"Metabolite":"Allantoin","WT1":"153.79","WT2":"237.43","WT3":"137.17","WT4":"227.40","WT5":"436.77","KO1":"182.11","KO2":"190.22","KO3":"353.82","KO4":"147.80","KO5":"149.83"},{"Metabolite":"alpha-Aminoadipate","WT1":"146.56","WT2":"35.43","WT3":"162.91","WT4":"121.00","WT5":"35.22","KO1":"723.85","KO2":"10.99","KO3":"36.26","KO4":"21.03","KO5":"18.21"},{"Metabolite":"alpha-Lipoamide","WT1":"3.93","WT2":"3.32","WT3":"3.06","WT4":"3.20","WT5":"3.43","KO1":"4.08","KO2":"3.73","KO3":"3.43","KO4":"3.26","KO5":"3.44"},{"Metabolite":"Alpha-Methylserine","WT1":"1.33","WT2":"2.56","WT3":"2.64","WT4":"1.75","WT5":"1.37","KO1":"1.45","KO2":"1.03","KO3":"1.18","KO4":"1.86","KO5":"0.95"},{"Metabolite":"Arg","WT1":"3.88","WT2":"1.88","WT3":"12.12","WT4":"2.26","WT5":"3.97","KO1":"3.23","KO2":"5.32","KO3":"4.49","KO4":"2.23","KO5":"3.44"},{"Metabolite":"Asn","WT1":"107.10","WT2":"100.52","WT3":"222.79","WT4":"106.53","WT5":"118.81","KO1":"122.37","KO2":"102.22","KO3":"89.63","KO4":"90.17","KO5":"52.29"},{"Metabolite":"Asp","WT1":"1161.92","WT2":"368.46","WT3":"775.66","WT4":"668.93","WT5":"654.36","KO1":"480.44","KO2":"538.48","KO3":"745.69","KO4":"515.88","KO5":"561.15"},{"Metabolite":"beta-Ala","WT1":"291.61","WT2":"246.82","WT3":"150.89","WT4":"172.31","WT5":"215.52","KO1":"236.47","KO2":"216.03","KO3":"244.76","KO4":"293.75","KO5":"318.39"},{"Metabolite":"Betaine","WT1":"1267.25","WT2":"488.16","WT3":"298.34","WT4":"363.46","WT5":"738.17","KO1":"155.76","KO2":"187.88","KO3":"470.57","KO4":"336.14","KO5":"488.13"},{"Metabolite":"Betaine aldehyde (+H2O)","WT1":"73.13","WT2":"23.81","WT3":"30.87","WT4":"29.98","WT5":"95.63","KO1":"29.06","KO2":"25.31","KO3":"36.59","KO4":"32.23","KO5":"46.07"},{"Metabolite":"Cadaverine","WT1":"0.20","WT2":"N.D.","WT3":"N.D.","WT4":"N.D.","WT5":"N.D.","KO1":"0.24","KO2":"0.33","KO3":"0.12","KO4":"0.31","KO5":"0.21"},{"Metabolite":"Carnitine","WT1":"209.46","WT2":"176.07","WT3":"185.92","WT4":"182.33","WT5":"188.74","KO1":"130.81","KO2":"109.34","KO3":"163.38","KO4":"136.18","KO5":"146.04"},{"Metabolite":"Carnosine","WT1":"0.74","WT2":"0.86","WT3":"0.56","WT4":"0.68","WT5":"0.61","KO1":"0.62","KO2":"0.62","KO3":"0.55","KO4":"0.80","KO5":"0.48"},{"Metabolite":"Choline","WT1":"365.26","WT2":"276.24","WT3":"201.57","WT4":"262.21","WT5":"348.66","KO1":"178.85","KO2":"121.75","KO3":"168.84","KO4":"167.32","KO5":"136.37"},{"Metabolite":"Citrulline","WT1":"12.77","WT2":"25.62","WT3":"17.63","WT4":"39.92","WT5":"31.47","KO1":"33.59","KO2":"17.28","KO3":"26.09","KO4":"17.06","KO5":"18.55"},{"Metabolite":"Creatine","WT1":"136.38","WT2":"251.02","WT3":"296.78","WT4":"171.45","WT5":"267.62","KO1":"281.27","KO2":"169.88","KO3":"225.50","KO4":"94.68","KO5":"231.74"},{"Metabolite":"Creatinine","WT1":"3.41","WT2":"4.60","WT3":"4.31","WT4":"4.25","WT5":"4.69","KO1":"5.07","KO2":"3.07","KO3":"5.01","KO4":"1.74","KO5":"2.80"},{"Metabolite":"Cyclohexylamine","WT1":"0.50","WT2":"0.47","WT3":"0.74","WT4":"0.37","WT5":"0.61","KO1":"0.62","KO2":"0.60","KO3":"0.59","KO4":"0.37","KO5":"0.63"},{"Metabolite":"Cys","WT1":"3.44","WT2":"5.57","WT3":"3.75","WT4":"4.16","WT5":"3.68","KO1":"4.37","KO2":"2.82","KO3":"4.90","KO4":"4.17","KO5":"4.17"},{"Metabolite":"Cystathionine","WT1":"40.66","WT2":"43.80","WT3":"73.15","WT4":"170.27","WT5":"36.90","KO1":"135.73","KO2":"10.37","KO3":"26.98","KO4":"79.48","KO5":"17.13"},{"Metabolite":"Cysteine-glutathione disulphide -Divalent","WT1":"7.10","WT2":"15.18","WT3":"8.82","WT4":"11.80","WT5":"10.87","KO1":"8.00","KO2":"7.27","KO3":"12.86","KO4":"13.45","KO5":"9.29"},{"Metabolite":"Cystine","WT1":"N.D.","WT2":"N.D.","WT3":"N.D.","WT4":"N.D.","WT5":"N.D.","KO1":"N.D.","KO2":"N.D.","KO3":"N.D.","KO4":"N.D.","KO5":"N.D."},{"Metabolite":"Cytidine","WT1":"7.51","WT2":"5.56","WT3":"6.16","WT4":"10.69","WT5":"11.93","KO1":"6.15","KO2":"22.54","KO3":"13.64","KO4":"8.00","KO5":"26.05"},{"Metabolite":"Cytosine","WT1":"N.D.","WT2":"N.D.","WT3":"N.D.","WT4":"N.D.","WT5":"0.19","KO1":"N.D.","KO2":"N.D.","KO3":"N.D.","KO4":"N.D.","KO5":"N.D."},{"Metabolite":"Dihydrouracil","WT1":"14053.29","WT2":"13742.22","WT3":"13865.25","WT4":"12654.31","WT5":"14504.59","KO1":"16067.03","KO2":"14808.92","KO3":"12000.47","KO4":"14005.38","KO5":"10394.78"},{"Metabolite":"Ethanolamine 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ID":"C00576","m/z":"120.102"},{"Metabolite":"Cadaverine","KEGG ID":"C01672","m/z":"103.1230"},{"Metabolite":"Carnitine","KEGG ID":"C00318,C00487,C15025","m/z":"162.1130"},{"Metabolite":"Carnosine","KEGG ID":"C00386","m/z":"114.0606"},{"Metabolite":"Choline","KEGG ID":"C00114","m/z":"104.1075"},{"Metabolite":"Citrulline","KEGG ID":"C00327","m/z":"176.1030"},{"Metabolite":"Creatine","KEGG ID":"C00300","m/z":"132.0768"},{"Metabolite":"Creatinine","KEGG ID":"C00791","m/z":"114.0662"},{"Metabolite":"Cyclohexylamine","KEGG ID":"C00571","m/z":"100.1121"},{"Metabolite":"Cys","KEGG ID":"C00097,C00736,C00793","m/z":"122.0270"},{"Metabolite":"Cystathionine","KEGG ID":"C00542,C02291","m/z":"223.0747"},{"Metabolite":"Cysteine-glutathione disulphide -Divalent","KEGG ID":"C05526","m/z":"214.0512"},{"Metabolite":"Cystine","KEGG ID":"","m/z":"241.0311"},{"Metabolite":"Cytidine","KEGG ID":"C00475","m/z":"244.0928"},{"Metabolite":"Cytosine","KEGG ID":"C00380","m/z":"112.0505"},{"Metabolite":"Dihydrouracil","KEGG ID":"C00429","m/z":"115.0502"},{"Metabolite":"Ethanolamine phosphate","KEGG ID":"C00346","m/z":"142.0264"},{"Metabolite":"GABA","KEGG ID":"C00334","m/z":"104.0706"},{"Metabolite":"gamma-Butyrobetaine","KEGG ID":"C01181","m/z":"146.1181"},{"Metabolite":"gamma-Glu-cys","KEGG ID":"C00669","m/z":"251.0696"},{"Metabolite":"gamma-Guanidinobutyrate","KEGG ID":"C01035","m/z":"146.0924"},{"Metabolite":"Gln","KEGG ID":"C00064,C00303,C00819","m/z":"147.0764"},{"Metabolite":"Glu","KEGG ID":"C00025,C00217,C00302","m/z":"148.0604"},{"Metabolite":"Glu-Glu","KEGG ID":"C01425","m/z":"277.1030"},{"Metabolite":"Glutathione(ox)","KEGG ID":"C00127","m/z":"307.0833"},{"Metabolite":"Glutathione(red)","KEGG ID":"C00051","m/z":"308.0911"},{"Metabolite":"Gly","KEGG ID":"C00037","m/z":"76.0393"},{"Metabolite":"Gly-Gly","KEGG ID":"C02037","m/z":"133.0608"},{"Metabolite":"Gly-Leu","KEGG ID":"No ID","m/z":"189.1234"},{"Metabolite":"Glycerophosphorylcholine","KEGG ID":"C00670","m/z":"258.1107"},{"Metabolite":"Guanidinoacetate","KEGG ID":"C00581","m/z":"118.0611"},{"Metabolite":"Guanidinosuccinate","KEGG ID":"C03139","m/z":"176.0666"},{"Metabolite":"Guanine","KEGG ID":"C00242","m/z":"152.0567"},{"Metabolite":"Guanosine","KEGG ID":"C00387","m/z":"284.0989"},{"Metabolite":"His","KEGG ID":"C00135,C00768,C06419","m/z":"156.0768"},{"Metabolite":"Histamine","KEGG ID":"C00388","m/z":"112.0869"},{"Metabolite":"Homoserine","KEGG ID":"C00263","m/z":"120.0655"},{"Metabolite":"Hydroxyproline","KEGG ID":"C01157","m/z":"132.0655"},{"Metabolite":"Hypotaurine","KEGG ID":"C00519","m/z":"110.0270"},{"Metabolite":"Hypoxanthine","KEGG ID":"C00262","m/z":"137.0458"},{"Metabolite":"Ile","KEGG ID":"C00407,C06418,C16434","m/z":"132.1019"},{"Metabolite":"Imidazole-4-acetate","KEGG ID":"C02835","m/z":"127.0502"},{"Metabolite":"Inosine","KEGG ID":"C00294","m/z":"269.0880"},{"Metabolite":"Isobutylamine","KEGG ID":"C02787","m/z":"74.0964"},{"Metabolite":"Kynurenine","KEGG ID":"C00328,C01718","m/z":"209.0921"},{"Metabolite":"Leu","KEGG ID":"C00123,C01570,C16439","m/z":"132.1019"},{"Metabolite":"Lys","KEGG ID":"C00047,C00739,C16440","m/z":"147.1128"},{"Metabolite":"Met","KEGG ID":"C00073,C00855,C01733","m/z":"150.0583"},{"Metabolite":"Methionine sulfoxide","KEGG ID":"C02989","m/z":"166.0532"},{"Metabolite":"N-Acetylglucosamine","KEGG ID":"C01132,C00645","m/z":"222.0972"},{"Metabolite":"N-Acetylglucosylamine","KEGG ID":"C01239","m/z":"221.1132"},{"Metabolite":"N-Acetylhistidine","KEGG ID":"C02997","m/z":"198.0873"},{"Metabolite":"N-Acetylornithine","KEGG ID":"C00437","m/z":"175.1077"},{"Metabolite":"N-Acetylputrescine","KEGG ID":"C02714","m/z":"131.1179"},{"Metabolite":"N-Acetylvaline","KEGG ID":"No ID","m/z":"160.0968"},{"Metabolite":"N-epsilon-Acetyllysine","KEGG ID":"C12989","m/z":"189.1234"},{"Metabolite":"N-gamma-Ethylglutamine","KEGG ID":"No ID","m/z":"175.1077"},{"Metabolite":"N-Methylalanine","KEGG ID":"C02721","m/z":"104.0706"},{"Metabolite":"N,N-Dimethylglycine","KEGG ID":"C01026","m/z":"104.0706"},{"Metabolite":"N6,N6,N6-Trimethyllysine","KEGG ID":"C03793","m/z":"189.1598"},{"Metabolite":"N8-Acetylspermidine","KEGG ID":"C01029","m/z":"188.1757"},{"Metabolite":"Nicotinamide","KEGG ID":"C00153","m/z":"123.0553"},{"Metabolite":"o-Acetylcarnitine","KEGG ID":"C02571","m/z":"204.1236"},{"Metabolite":"Ophthalmate","KEGG ID":"No ID","m/z":"290.1347"},{"Metabolite":"Ornithine","KEGG ID":"C00077,C00515,C01602","m/z":"133.0972"},{"Metabolite":"Phe","KEGG ID":"C00079,C02057,C02265","m/z":"166.0863"},{"Metabolite":"Phosphorylcholine","KEGG ID":"C00588","m/z":"184.0739"},{"Metabolite":"Pipecolate","KEGG ID":"C00408","m/z":"130.0863"},{"Metabolite":"Pro","KEGG ID":"C00148,C00763,C16435","m/z":"116.0706"},{"Metabolite":"Pterin","KEGG ID":"C00715","m/z":"164.0567"},{"Metabolite":"Purine","KEGG ID":"C15587","m/z":"121.0509"},{"Metabolite":"Putrescine(1,4-Butanediamine)","KEGG ID":"C00134","m/z":"89.1073"},{"Metabolite":"Pyridoxal","KEGG ID":"C00250","m/z":"168.0655"},{"Metabolite":"Pyridoxamine","KEGG ID":"C00534","m/z":"169.0972"},{"Metabolite":"Pyridoxamine 5'-phosphate","KEGG ID":"C00647","m/z":"249.0635"},{"Metabolite":"Riboflavin","KEGG ID":"C00255","m/z":"377.1456"},{"Metabolite":"S-Lactoylglutathione","KEGG ID":"C03451","m/z":"380.1122"},{"Metabolite":"S-Methylmethionine","KEGG ID":"C03172","m/z":"164.0745"},{"Metabolite":"SAH","KEGG ID":"C00021","m/z":"193.0681"},{"Metabolite":"SAM+","KEGG ID":"C00019","m/z":"200.0762"},{"Metabolite":"Saccharopine","KEGG ID":"C00449","m/z":"277.139"},{"Metabolite":"Sarcosine","KEGG ID":"C00213","m/z":"90.0550"},{"Metabolite":"SDMA","KEGG ID":"No ID","m/z":"203.150"},{"Metabolite":"Ser","KEGG ID":"C00065,C00716,C00740","m/z":"106.0499"},{"Metabolite":"Serotonin","KEGG ID":"C00780","m/z":"177.1022"},{"Metabolite":"Spermidine","KEGG ID":"C00315","m/z":"146.1652"},{"Metabolite":"Spermine","KEGG ID":"C00750","m/z":"102.1151"},{"Metabolite":"Taurine","KEGG ID":"C00245","m/z":"126.0219"},{"Metabolite":"Taurocyamine","KEGG ID":"C01959","m/z":"168.044"},{"Metabolite":"Thiamine","KEGG ID":"C00378","m/z":"265.1123"},{"Metabolite":"Thiamine monophosphate","KEGG ID":"C01081","m/z":"345.0786"},{"Metabolite":"Thr","KEGG ID":"C00188,C00820","m/z":"120.0655"},{"Metabolite":"Thymidine","KEGG ID":"C00214","m/z":"243.0975"},{"Metabolite":"Thymine","KEGG ID":"C00178","m/z":"127.0502"},{"Metabolite":"Trigonelline","KEGG ID":"C01004","m/z":"138.0550"},{"Metabolite":"Trimethylamine N-oxide","KEGG ID":"C01104","m/z":"76.0757"},{"Metabolite":"Trp","KEGG ID":"C00078,C00525,C00806","m/z":"205.0972"},{"Metabolite":"Tyr","KEGG ID":"C00082,C01536,C06420","m/z":"182.0812"},{"Metabolite":"Tyramine","KEGG ID":"C00483","m/z":"138.0913"},{"Metabolite":"Uracil","KEGG ID":"C00106","m/z":"113.0346"},{"Metabolite":"Urea","KEGG ID":"C00086","m/z":"61.0396"},{"Metabolite":"Uridine","KEGG ID":"C00299","m/z":"245.0768"},{"Metabolite":"Val","KEGG ID":"C00183,C06417,C16436","m/z":"118.0863"},{"Metabolite":"Xanthine","KEGG ID":"C00385","m/z":"153.0407"},{"Metabolite":"Xanthosine","KEGG ID":"C01762","m/z":"285.0830"}]
}

}