{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002457","ANALYSIS_ID":"AN004009","VERSION":"1","CREATED_ON":"January 31, 2023, 11:26 am"},
"PROJECT":{"PROJECT_TITLE":"Mouse kidney metabolomic studies","PROJECT_TYPE":"MS quantitative analysis","PROJECT_SUMMARY":"Chronic kidney disease secondary to cystic kidney disease is a leading cause of mortality in patients with tuberous sclerosis complex (TSC) disease. The mechanisms underlying TSC cystic kidney disease are obscure, with no interventions available to prevent cyst formation. Here, we reveal for the first time the misregulated metabolic pathways in TSC kidneys and their relevance to TSC-associated cytogenesis. To this end, we have analyzed the metabolic profile of the whole kidney as well as sorted proximal tubule cell (PTCs) extracts. The metabolomics data show that Tsc1 deletion in nephron progenitor cells changes the arginine biosynthesis pathway as well as a substantial number of metabolic pathways. These changes were associated with overexpression of argininosuccinate synthetase 1 (ASS1), a rate-limiting enzyme in the arginine biosynthetic pathway in TSC KO mice and human kidneys. The rise in ASS1 expression is dependent on mTORC1 activity. Arginine depletion in vitro and in vivo prevented the rise in mTORC1 activity and cell cycle progression and averted the overexpression of previously described cytogenetic signaling proteins, including c-Myc and P65. Accordingly, an arginine-depleted diet substantially reduced the TSC cystic load, indicating the potential therapeutic effects of arginine deprivation as a treatment of TSC-associated kidney disease.","INSTITUTE":"Hadassah Medical Center","DEPARTMENT":"Pediatric Nephrology","LABORATORY":"Wohl Institute for Translational Medicine","LAST_NAME":"Ben-Dov","FIRST_NAME":"Iddo","ADDRESS":"Ein Karem Campus, Jerusalem, NA, 9211001, Israel","EMAIL":"iddo@hadassah.org.il","PHONE":"+97226776881","FUNDING_SOURCE":"This work was supported by grants from the Israel Science Foundation (MN 2030/21 and OV 2358/18), the TSC alliance research grant (OV), the research authority of Hadassah Hebrew University Medical Center (OV). OV and MN are Wohl’s Translation Research Institute research associates at Hadassah-Hebrew University Medical Center","CONTRIBUTORS":"Athar Amleh, Lana Watad, Ifat Abramovich, Bella Agranovich, Eyal Gottlieb, Iddo Z. Ben-Dov, Morris Nechama and Oded Volovelsky"},
"STUDY":{"STUDY_TITLE":"Mouse kidney metabolomics (Whole kidney)","STUDY_SUMMARY":"Here, we reveal for the first time the misregulated metabolic pathways in TSC kidneys and their relevance to TSC-associated cytogenesis. To this end, we have analyzed the metabolic profile of the whole kidney as well as sorted proximal tubule cell (PTCs) extracts. The metabolomics data show that Tsc1 deletion in nephron progenitor cells changes the arginine biosynthesis pathway as well as a substantial number of metabolic pathways.","INSTITUTE":"Hadassah Medical Center","LAST_NAME":"Ben-Dov","FIRST_NAME":"Iddo","ADDRESS":"Hadassah Medical Center, Jerusalem, Israel 91120","EMAIL":"iddo@hadassah.org.il","NUM_GROUPS":"3","TOTAL_SUBJECTS":"26","STUDY_TYPE":"MS quantitative analysis","PHONE":"+97226776881"},
"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090","GENDER":"Male and female"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"1",
"Sample ID":"01_WT-3",
"Factors":{"Genotype":"Wild-type","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"01_WT-3.raw"}
},
{
"Subject ID":"2",
"Sample ID":"02_WT-5",
"Factors":{"Genotype":"Wild-type","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"02_WT-5.raw"}
},
{
"Subject ID":"3",
"Sample ID":"03_WT-6",
"Factors":{"Genotype":"Wild-type","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"03_WT-6.raw"}
},
{
"Subject ID":"4",
"Sample ID":"04_WT-17",
"Factors":{"Genotype":"Wild-type","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"04_WT-17.raw"}
},
{
"Subject ID":"5",
"Sample ID":"05_WT-31",
"Factors":{"Genotype":"Wild-type","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"05_WT-31.raw"}
},
{
"Subject ID":"6",
"Sample ID":"06_WT-8",
"Factors":{"Genotype":"Wild-type","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"06_WT-8.raw"}
},
{
"Subject ID":"7",
"Sample ID":"07_WT-10",
"Factors":{"Genotype":"Wild-type","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"07_WT-10.raw"}
},
{
"Subject ID":"8",
"Sample ID":"08_WT-32",
"Factors":{"Genotype":"Wild-type","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"08_WT-32.raw"}
},
{
"Subject ID":"9",
"Sample ID":"09_Tsc1_KO-1",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"09_Tsc1_KO-1.raw"}
},
{
"Subject ID":"10",
"Sample ID":"10_Tsc1_KO-2",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"10_Tsc1_KO-2.raw"}
},
{
"Subject ID":"11",
"Sample ID":"11_Tsc1_KO-7",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"11_Tsc1_KO-7.raw"}
},
{
"Subject ID":"12",
"Sample ID":"12_Tsc1_KO-15",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"12_Tsc1_KO-15.raw"}
},
{
"Subject ID":"13",
"Sample ID":"13_Tsc1_KO-18",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"13_Tsc1_KO-18.raw"}
},
{
"Subject ID":"14",
"Sample ID":"14_Tsc1_KO-46",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"14_Tsc1_KO-46.raw"}
},
{
"Subject ID":"15",
"Sample ID":"15_Tsc1_KO-38",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"none"},
"Additional sample data":{"RAW_FILE_NAME":"15_Tsc1_KO-38.raw"}
},
{
"Subject ID":"16",
"Sample ID":"16_WT_Rapa-2",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"rapamycin"},
"Additional sample data":{"RAW_FILE_NAME":"16_WT_Rapa-2.raw"}
},
{
"Subject ID":"17",
"Sample ID":"17_WT_Rapa-23",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"rapamycin"},
"Additional sample data":{"RAW_FILE_NAME":"17_WT_Rapa-23.raw"}
},
{
"Subject ID":"18",
"Sample ID":"18_WT_Rapa-25",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"rapamycin"},
"Additional sample data":{"RAW_FILE_NAME":"18_WT_Rapa-25.raw"}
},
{
"Subject ID":"19",
"Sample ID":"19_WT_Rapa-27",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"rapamycin"},
"Additional sample data":{"RAW_FILE_NAME":"19_WT_Rapa-27.raw"}
},
{
"Subject ID":"20",
"Sample ID":"20_WT_Rapa-29",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"rapamycin"},
"Additional sample data":{"RAW_FILE_NAME":"20_WT_Rapa-29.raw"}
},
{
"Subject ID":"21",
"Sample ID":"21_WT_Rapa-31",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"rapamycin"},
"Additional sample data":{"RAW_FILE_NAME":"21_WT_Rapa-31.raw"}
},
{
"Subject ID":"22",
"Sample ID":"22_KO_Rapa-14",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"rapamycin"},
"Additional sample data":{"RAW_FILE_NAME":"22_KO_Rapa-14.raw"}
},
{
"Subject ID":"23",
"Sample ID":"23_KO_Rapa-22",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"rapamycin"},
"Additional sample data":{"RAW_FILE_NAME":"23_KO_Rapa-22.raw"}
},
{
"Subject ID":"24",
"Sample ID":"24_KO_Rapa-51",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"rapamycin"},
"Additional sample data":{"RAW_FILE_NAME":"24_KO_Rapa-51.raw"}
},
{
"Subject ID":"25",
"Sample ID":"25_KO_Rapa-50",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"rapamycin"},
"Additional sample data":{"RAW_FILE_NAME":"25_KO_Rapa-50.raw"}
},
{
"Subject ID":"26",
"Sample ID":"26_KO_Rapa-17",
"Factors":{"Genotype":"Tsc1-knockout","Treatment":"rapamycin"},
"Additional sample data":{"RAW_FILE_NAME":"26_KO_Rapa-17.raw"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Snap-frozen kidneys were transferred into 0.5 ml homogenization tubes prefilled with 1.4mm ceramic beads (CK14, # P000933-LYSK0-A, Bertin corp) and cold (-20°C) metabolites extraction solvent (Methanol: acetonitrile: water at a ratio of 5:3:2 respectively)","SAMPLE_TYPE":"Kidney"},
"TREATMENT":{"TREATMENT_SUMMARY":"A mixture of six labeled internal standards was added to the extraction solution for quality control (13C6-Glucose, 13C5-Glutamine, 13C5-Glutamate, 13C1-Alanine, 13C3-Pyruvate and 13C3-Lactate). The exact volume at each tube was adjusted according to tissue weight (average volume of 200 µl). The samples were homogenized using Precellys 24 tissue homogenizer (Bertin Technologies) precooled to 4°C (3 cycles × 30 s at 6000 rpm, with a 30 s gap between each cycle) and later centrifuged at 18,000 g for 15 min at 4°C. The supernatants were transferred into HPLC glass vials and kept at −80°C prior to LC-MS analysis."},
"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"The samples were homogenized using Precellys 24 tissue homogenizer (Bertin Technologies) precooled to 4°C (3 cycles × 30 s at 6000 rpm, with a 30 s gap between each cycle) and later centrifuged at 18,000 g for 15 min at 4°C. The supernatants were transferred into HPLC glass vials and kept at −80°C prior to LC-MS analysis."},
"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"UPLC setup consisted a ZIC-pHILIC column (SeQuant; 150 mm × 2.1 mm, 5 μm; Merck). 5 µl of cells or kidney extracts were injected using an autosampler. Compounds were separated using a 15 minutes gradient, starting at 20% aqueous (20 mM ammonium carbonate adjusted to pH 9.2 with 0.1% of 25% ammonium hydroxide) and 80% organic (acetonitrile), terminated with 20% acetonitrile. Flow rate and column temperature were kept at 0.2 ml/min and 45°C, respectively for a total run time of 27 min","CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Thermo Dionex Ultimate 3000","COLUMN_NAME":"Merck SeQuant ZIC-pHILIC (150 x 2.1mm,5um)","SOLVENT_A":"20% water/80% acetonitrile; 20 mM ammonium carbonate; 0.1% of 25% ammonium hydroxide (adjusted to pH 9.2)","SOLVENT_B":"80%water/20% acetonitrile","FLOW_GRADIENT":"15 min terminated with 20% acetonitrile","FLOW_RATE":"0.2 ml/min","COLUMN_TEMPERATURE":"45"},
"ANALYSIS":{"ANALYSIS_TYPE":"MS","LABORATORY_NAME":"Technion Mass Spect"},
"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"UNSPECIFIED","MS_COMMENTS":"Briefly, Dionex Ultimate ultra-high-performance liquid chromatography (UPLC) system coupled to Orbitrap Q-Exactive mass spectrometer (Thermo Fisher Scientific) was used. The resolution was set to 35,000 at 200 mass/charge ratio (m/z) with electrospray ionization and polarity switching mode to enable both positive and negative ions across a mass range of 67–1000 m/z."},
"MS_METABOLITE_DATA":{
"Units":"concentration",
"Data":[{"Metabolite":"10-HAD","01_WT-3":"209523.6549","02_WT-5":"851489.9738","03_WT-6":"365540.4016","04_WT-17":"521593.0597","05_WT-31":"776905.8694","06_WT-8":"369002.5551","07_WT-10":"435490.6698","08_WT-32":"710597.4313","09_Tsc1_KO-1":"737914.9866","10_Tsc1_KO-2":"584043.4435","11_Tsc1_KO-7":"663143.7092","12_Tsc1_KO-15":"391828.4644","13_Tsc1_KO-18":"300804.2363","14_Tsc1_KO-46":"442528.9689","15_Tsc1_KO-38":"342076.4679","16_WT_Rapa-2":"284596.0427","17_WT_Rapa-23":"327816.0071","18_WT_Rapa-25":"360153.1801","19_WT_Rapa-27":"185476.782","20_WT_Rapa-29":"322948.1679","21_WT_Rapa-31":"304485.035","22_KO_Rapa-14":"330220.4511","23_KO_Rapa-22":"449677.4666","24_KO_Rapa-51":"979485.8774","25_KO_Rapa-50":"250873.8107","26_KO_Rapa-17":"332927.836"},{"Metabolite":"10-Hydroxydecanoic acid","01_WT-3":"146963.0975","02_WT-5":"563088.2799","03_WT-6":"304582.4531","04_WT-17":"372727.1308","05_WT-31":"510568.7953","06_WT-8":"359673.8774","07_WT-10":"284683.3022","08_WT-32":"306113.1902","09_Tsc1_KO-1":"500508.2382","10_Tsc1_KO-2":"278692.8329","11_Tsc1_KO-7":"286661.1266","12_Tsc1_KO-15":"170196.7251","13_Tsc1_KO-18":"162076.9761","14_Tsc1_KO-46":"244660.9653","15_Tsc1_KO-38":"266965.2307","16_WT_Rapa-2":"240798.7086","17_WT_Rapa-23":"311736.5804","18_WT_Rapa-25":"244419.9207","19_WT_Rapa-27":"117543.0125","20_WT_Rapa-29":"215297.742","21_WT_Rapa-31":"206046.2634","22_KO_Rapa-14":"117636.3814","23_KO_Rapa-22":"234197.5627","24_KO_Rapa-51":"451667.4245","25_KO_Rapa-50":"207804.9086","26_KO_Rapa-17":"139694.1296"},{"Metabolite":"14-Methylhexadecanoic acid","01_WT-3":"2395341.225","02_WT-5":"2071235.137","03_WT-6":"2637848.267","04_WT-17":"2331064.834","05_WT-31":"2557150.245","06_WT-8":"1616723.674","07_WT-10":"2072475.384","08_WT-32":"3411704.47","09_Tsc1_KO-1":"2018259.167","10_Tsc1_KO-2":"4636217.245","11_Tsc1_KO-7":"2535950.402","12_Tsc1_KO-15":"1922964.477","13_Tsc1_KO-18":"1740927.638","14_Tsc1_KO-46":"2206771.771","15_Tsc1_KO-38":"1582170.513","16_WT_Rapa-2":"1598596.439","17_WT_Rapa-23":"2324360.395","18_WT_Rapa-25":"1975822.777","19_WT_Rapa-27":"1226642.811","20_WT_Rapa-29":"2724339.72","21_WT_Rapa-31":"6345258.828","22_KO_Rapa-14":"1248202.298","23_KO_Rapa-22":"2815335.441","24_KO_Rapa-51":"2271570.69","25_KO_Rapa-50":"2889349.397","26_KO_Rapa-17":"2573924.582"},{"Metabolite":"1-Aminocyclopropanecarboxylate","01_WT-3":"613883.9069","02_WT-5":"566208.763","03_WT-6":"647408.4694","04_WT-17":"703032.5569","05_WT-31":"531979.3862","06_WT-8":"593315.2552","07_WT-10":"704348.008","08_WT-32":"691235.7028","09_Tsc1_KO-1":"516347.9429","10_Tsc1_KO-2":"480728.3695","11_Tsc1_KO-7":"549307.0893","12_Tsc1_KO-15":"545843.6899","13_Tsc1_KO-18":"517775.2166","14_Tsc1_KO-46":"529308.3548","15_Tsc1_KO-38":"606858.1091","16_WT_Rapa-2":"851336.1465","17_WT_Rapa-23":"773197.3097","18_WT_Rapa-25":"898918.4409","19_WT_Rapa-27":"811057.9088","20_WT_Rapa-29":"727025.3503","21_WT_Rapa-31":"775179.1545","22_KO_Rapa-14":"636930.18","23_KO_Rapa-22":"524456.6225","24_KO_Rapa-51":"429610.3629","25_KO_Rapa-50":"651506.2364","26_KO_Rapa-17":"485811.17"},{"Metabolite":"1-Methyladenosine","01_WT-3":"29804406.75","02_WT-5":"28067250.6","03_WT-6":"26969382.54","04_WT-17":"34578301.33","05_WT-31":"25491732.57","06_WT-8":"19415806.65","07_WT-10":"52722481.01","08_WT-32":"35793420.63","09_Tsc1_KO-1":"26377155.57","10_Tsc1_KO-2":"20588515.92","11_Tsc1_KO-7":"116063198.7","12_Tsc1_KO-15":"47903971.2","13_Tsc1_KO-18":"29493055.86","14_Tsc1_KO-46":"23516011.96","15_Tsc1_KO-38":"22672620.65","16_WT_Rapa-2":"29914515.31","17_WT_Rapa-23":"36172169.5","18_WT_Rapa-25":"33962036.84","19_WT_Rapa-27":"60159086.02","20_WT_Rapa-29":"43001700.02","21_WT_Rapa-31":"37421671.08","22_KO_Rapa-14":"81038191.62","23_KO_Rapa-22":"59307927.27","24_KO_Rapa-51":"54982062.85","25_KO_Rapa-50":"74419792.3","26_KO_Rapa-17":"34269665.2"},{"Metabolite":"2,4-Dihydroxypteridine","01_WT-3":"414134.2678","02_WT-5":"327753.1849","03_WT-6":"148985.6166","04_WT-17":"152885.259","05_WT-31":"128122.5815","06_WT-8":"92926.50024","07_WT-10":"299555.7907","08_WT-32":"144002.0051","09_Tsc1_KO-1":"379095.1238","10_Tsc1_KO-2":"94167.15052","11_Tsc1_KO-7":"127307.9712","12_Tsc1_KO-15":"600096.8841","13_Tsc1_KO-18":"264715.8097","14_Tsc1_KO-46":"451162.1285","15_Tsc1_KO-38":"288584.086","16_WT_Rapa-2":"105845.9228","17_WT_Rapa-23":"284055.0894","18_WT_Rapa-25":"439583.3778","19_WT_Rapa-27":"191717.2161","20_WT_Rapa-29":"304808.969","21_WT_Rapa-31":"239646.4639","22_KO_Rapa-14":"130943.4771","23_KO_Rapa-22":"243186.5759","24_KO_Rapa-51":"76470.01063","25_KO_Rapa-50":"76823.21542","26_KO_Rapa-17":"229608.9021"},{"Metabolite":"2-Acetamido-2-Deoxy-Beta-D-Glucosylamine","01_WT-3":"786456.3711","02_WT-5":"581387.9426","03_WT-6":"752006.0447","04_WT-17":"576418.6122","05_WT-31":"395037.3721","06_WT-8":"594975.7326","07_WT-10":"565065.7997","08_WT-32":"743866.2381","09_Tsc1_KO-1":"260691.2812","10_Tsc1_KO-2":"264567.8889","11_Tsc1_KO-7":"393203.2776","12_Tsc1_KO-15":"435863.1075","13_Tsc1_KO-18":"366418.3636","14_Tsc1_KO-46":"341272.1599","15_Tsc1_KO-38":"322429.6225","16_WT_Rapa-2":"359747.2895","17_WT_Rapa-23":"407380.8937","18_WT_Rapa-25":"331953.9275","19_WT_Rapa-27":"484041.5316","20_WT_Rapa-29":"398683.8785","21_WT_Rapa-31":"330413.1217","22_KO_Rapa-14":"411363.14","23_KO_Rapa-22":"336406.6528","24_KO_Rapa-51":"370896.1565","25_KO_Rapa-50":"440940.1792","26_KO_Rapa-17":"267822.9136"},{"Metabolite":"2-Aminoadipate","01_WT-3":"24381843.24","02_WT-5":"19605116.67","03_WT-6":"19882163.24","04_WT-17":"20743992.19","05_WT-31":"14638717.18","06_WT-8":"22195468.39","07_WT-10":"23230787.46","08_WT-32":"16942590.81","09_Tsc1_KO-1":"15171987.62","10_Tsc1_KO-2":"13321139.82","11_Tsc1_KO-7":"13754553.36","12_Tsc1_KO-15":"13985075.67","13_Tsc1_KO-18":"14960516.76","14_Tsc1_KO-46":"13055388.94","15_Tsc1_KO-38":"14256030.8","16_WT_Rapa-2":"47174597.99","17_WT_Rapa-23":"25894479.52","18_WT_Rapa-25":"34799917.3","19_WT_Rapa-27":"28959359.39","20_WT_Rapa-29":"24431173.25","21_WT_Rapa-31":"27576818.46","22_KO_Rapa-14":"43846027.92","23_KO_Rapa-22":"22884517.27","24_KO_Rapa-51":"20868998.98","25_KO_Rapa-50":"39704789.87","26_KO_Rapa-17":"32058778.39"},{"Metabolite":"2-Aminoisobutyrate","01_WT-3":"26481036.05","02_WT-5":"13802814.87","03_WT-6":"16887759.03","04_WT-17":"19336004.56","05_WT-31":"14175345.22","06_WT-8":"13268169.92","07_WT-10":"17308006.49","08_WT-32":"20748593.14","09_Tsc1_KO-1":"18176275.13","10_Tsc1_KO-2":"13921678.34","11_Tsc1_KO-7":"15103557.15","12_Tsc1_KO-15":"12674361.82","13_Tsc1_KO-18":"12047701.27","14_Tsc1_KO-46":"13709816.3","1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Acid","01_WT-3":"1832082.166","02_WT-5":"1539029.417","03_WT-6":"2253785.778","04_WT-17":"691934.9865","05_WT-31":"765683.6908","06_WT-8":"1299275.363","07_WT-10":"1673504.003","08_WT-32":"1341200.605","09_Tsc1_KO-1":"1606048.859","10_Tsc1_KO-2":"7878222.846","11_Tsc1_KO-7":"1688054.504","12_Tsc1_KO-15":"852712.2399","13_Tsc1_KO-18":"878708.5087","14_Tsc1_KO-46":"1543995.328","15_Tsc1_KO-38":"1135492.542","16_WT_Rapa-2":"1155525.663","17_WT_Rapa-23":"1922335.023","18_WT_Rapa-25":"1068247.68","19_WT_Rapa-27":"1489735.685","20_WT_Rapa-29":"1359509.983","21_WT_Rapa-31":"1963004.191","22_KO_Rapa-14":"526972.362","23_KO_Rapa-22":"1268771.994","24_KO_Rapa-51":"999070.0417","25_KO_Rapa-50":"1327253.452","26_KO_Rapa-17":"1031774.679"},{"Metabolite":"Xylitol/Ribitol/Arabitol","01_WT-3":"4990931.911","02_WT-5":"3784286.865","03_WT-6":"4864503.895","04_WT-17":"5904796.788","05_WT-31":"3770841.12","06_WT-8":"4113789.778","07_WT-10":"5819011.68","08_WT-32":"5922883.74","09_Tsc1_KO-1":"3736973.703","10_Tsc1_KO-2":"3307008.639","11_Tsc1_KO-7":"4437384.05","12_Tsc1_KO-15":"4033604.98","13_Tsc1_KO-18":"4670648.923","14_Tsc1_KO-46":"3980139.234","15_Tsc1_KO-38":"3297909.638","16_WT_Rapa-2":"4705348.817","17_WT_Rapa-23":"6718010.763","18_WT_Rapa-25":"6657235.802","19_WT_Rapa-27":"7040761.563","20_WT_Rapa-29":"6756115.758","21_WT_Rapa-31":"5597691.625","22_KO_Rapa-14":"5902852.248","23_KO_Rapa-22":"4528991.204","24_KO_Rapa-51":"4155846.023","25_KO_Rapa-50":"5144201.614","26_KO_Rapa-17":"3901559.771"}],
"Metabolites":[{"Metabolite":"10-HAD","Match":"NA","name":"10-HAD","HMDB":"NA","PubChem":"NA","ChEBI":"NA","KEGG":"NA","METLIN":"NA","SMILES":"NA"},{"Metabolite":"10-Hydroxydecanoic acid","Match":"10-Hydroxydecanoic acid","name":"10-Hydroxydecanoic acid","HMDB":"NA","PubChem":"74300","ChEBI":"NA","KEGG":"NA","METLIN":"NA","SMILES":"NA"},{"Metabolite":"14-Methylhexadecanoic acid","Match":"(S)-14-Methylhexadecanoic acid","name":"(S)-14-Methylhexadecanoic acid","HMDB":"HMDB0031067","PubChem":"22207","ChEBI":"84874","KEGG":"NA","METLIN":"NA","SMILES":"CCC(C)CCCCCCCCCCCCC(=O)O"},{"Metabolite":"1-Aminocyclopropanecarboxylate","Match":"1-Aminocyclopropanecarboxylic acid","name":"1-Aminocyclopropanecarboxylic 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(AMP)","Match":"Adenosine monophosphate","name":"Adenosine 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acid","HMDB":"HMDB0002212","PubChem":"10467","ChEBI":"28822","KEGG":"C06425","METLIN":"401","SMILES":"CCCCCCCCCCCCCCCCCCCC(=O)O"},{"Metabolite":"Arachidonic acid","Match":"Arachidonic acid","name":"Arachidonic acid","HMDB":"HMDB0001043","PubChem":"444899","ChEBI":"15843","KEGG":"C00219","METLIN":"193","SMILES":"CCCCC/C=CC/C=CC/C=CC/C=CCCCC(=O)O"},{"Metabolite":"Arginine","Match":"L-Arginine","name":"L-Arginine","HMDB":"HMDB0000517","PubChem":"6322","ChEBI":"16467","KEGG":"C00062","METLIN":"5502","SMILES":"N[C@@H](CCCNC(N)=N)C(O)=O"},{"Metabolite":"Argininosuccinate","Match":"Argininosuccinic acid","name":"Argininosuccinic acid","HMDB":"HMDB0000052","PubChem":"16950","ChEBI":"15682","KEGG":"C03406","METLIN":"5115","SMILES":"N[C@@H](CCCNC(=N)N[C@@H](CC(O)=O)C(O)=O)C(O)=O"},{"Metabolite":"Asparagine","Match":"L-Asparagine","name":"L-Asparagine","HMDB":"HMDB0000168","PubChem":"6267","ChEBI":"17196","KEGG":"C00152","METLIN":"14","SMILES":"N[C@@H](CC(N)=O)C(O)=O"},{"Metabolite":"Aspartate","Match":"L-Aspartic acid","name":"L-Aspartic acid","HMDB":"HMDB0000191","PubChem":"5960","ChEBI":"17053","KEGG":"C00049","METLIN":"5206","SMILES":"N[C@@H](CC(O)=O)C(O)=O"},{"Metabolite":"Behenic acid","Match":"Behenic acid","name":"Behenic acid","HMDB":"HMDB0000944","PubChem":"8215","ChEBI":"28941","KEGG":"C08281","METLIN":"260","SMILES":"CCCCCCCCCCCCCCCCCCCCCC(=O)O"},{"Metabolite":"Beta-Alanine","Match":"beta-Alanine","name":"beta-Alanine","HMDB":"HMDB0000056","PubChem":"239","ChEBI":"16958","KEGG":"C00099","METLIN":"5119","SMILES":"NCCC(O)=O"},{"Metabolite":"Beta-Glycerophosphate","Match":"Beta-Glycerophosphoric acid","name":"Beta-Glycerophosphoric acid","HMDB":"HMDB0002520","PubChem":"2526","ChEBI":"17270","KEGG":"C02979","METLIN":"6708","SMILES":"C(C(CO)OP(=O)(O)O)O"},{"Metabolite":"beta-Hydroxyisovaleric acid","Match":"3-Hydroxyisovaleric acid","name":"3-Hydroxyisovaleric acid","HMDB":"HMDB0000754","PubChem":"69362","ChEBI":"37084","KEGG":"C20827","METLIN":"5722","SMILES":"CC(C)(CC(=O)O)O"},{"Metabolite":"Betaine","Match":"Betaine","name":"Betaine","HMDB":"HMDB0000043","PubChem":"247","ChEBI":"17750","KEGG":"C00719","METLIN":"287","SMILES":"C[N+](C)(C)CC([O-])=O"},{"Metabolite":"Beta-Nicotinamide Adenine Dinucleotide","Match":"NADH","name":"NADH","HMDB":"HMDB0000902","PubChem":"5893","ChEBI":"44215","KEGG":"C00003","METLIN":"5858","SMILES":"NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O"},{"Metabolite":"Butyryl-L-carnitine","Match":"Butyrylcarnitine","name":"Butyrylcarnitine","HMDB":"HMDB0002013","PubChem":"439829","ChEBI":"NA","KEGG":"C02862","METLIN":"6436","SMILES":"CCCC(=O)OC(CC(=O)[O-])C[N+](C)(C)C"},{"Metabolite":"Carnitine","Match":"L-Carnitine","name":"L-Carnitine","HMDB":"HMDB0000062","PubChem":"10917","ChEBI":"16347","KEGG":"C00318","METLIN":"52","SMILES":"C[N+](C)(C)C[C@H](O)CC([O-])=O"},{"Metabolite":"Carnosine","Match":"Carnosine","name":"Carnosine","HMDB":"HMDB0000033","PubChem":"439224","ChEBI":"15727","KEGG":"C00386","METLIN":"38","SMILES":"NCCC(=O)N[C@@H](CC1=CN=CN1)C(O)=O"},{"Metabolite":"CDP-Ethanolamine","Match":"CDP-Ethanolamine","name":"CDP-Ethanolamine","HMDB":"HMDB0001564","PubChem":"123727","ChEBI":"16732","KEGG":"C00570","METLIN":"3538","SMILES":"NCCOP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(N)=NC1=O"},{"Metabolite":"cis-11-Eicosenoic acid","Match":"Eicosenoic acid","name":"Eicosenoic acid","HMDB":"HMDB0002231","PubChem":"5282768","ChEBI":"32425","KEGG":"C16526","METLIN":"6563","SMILES":"CCCCCCCC/C=CCCCCCCCCCC(=O)O"},{"Metabolite":"Cis-4-Hydroxy-D-Proline","Match":"cis-4-Hydroxy-D-proline","name":"cis-4-Hydroxy-D-proline","HMDB":"HMDB0060460","PubChem":"440014","ChEBI":"16231","KEGG":"C03440","METLIN":"NA","SMILES":"O[C@H]1CN[C@H](C1)C(O)=O"},{"Metabolite":"cis-5-Dodecenoic acid","Match":"5-Dodecenoic acid","name":"5-Dodecenoic acid","HMDB":"HMDB0000529","PubChem":"5312378","ChEBI":"750110","KEGG":"NA","METLIN":"5514","SMILES":"CCCCCC/C=CCCCC(=O)O"},{"Metabolite":"cis-7,10,13,16-Docosatetraenoic acid","Match":"(7Z,10Z,13Z,16Z)-docosatetraenoate","name":"(7Z,10Z,13Z,16Z)-docosatetraenoate","HMDB":"HMDB0062580","PubChem":"5497181","ChEBI":"53487","KEGG":"C16527","METLIN":"6560","SMILES":"CCCCCC=C/CC=C/CC=C/CC=C/CCCCCC(O)=O"},{"Metabolite":"cis-Aconitate","Match":"cis-Aconitic acid","name":"cis-Aconitic 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phosphate","HMDB":"HMDB0011691","PubChem":"53481030","ChEBI":"17858","KEGG":"C00127","METLIN":"NA","SMILES":"C1=CN(C(=O)N=C1N)C2[C@H]3[C@@H]([C@H](O2)CO)OP(=O)(O3)O"},{"Metabolite":"Cytidine Diphosphate (CDP)","Match":"CDP","name":"CDP","HMDB":"HMDB0001546","PubChem":"6132","ChEBI":"17239","KEGG":"C00112","METLIN":"6313","SMILES":"NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O"},{"Metabolite":"Cytidine Monophosphate (CMP)","Match":"Cytidine monophosphate","name":"Cytidine monophosphate","HMDB":"HMDB0000095","PubChem":"6131","ChEBI":"17361","KEGG":"C00055","METLIN":"5143","SMILES":"NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O"},{"Metabolite":"Decanoic acid","Match":"Capric acid","name":"Capric acid","HMDB":"HMDB0000511","PubChem":"2969","ChEBI":"30813","KEGG":"C01571","METLIN":"336","SMILES":"CCCCCCCCCC(=O)O"},{"Metabolite":"Deoxycarnitine","Match":"4-Trimethylammoniobutanoic acid","name":"4-Trimethylammoniobutanoic acid","HMDB":"HMDB0001161","PubChem":"134","ChEBI":"1941","KEGG":"C01181","METLIN":"6043","SMILES":"C[N+](C)(C)CCCC(=O)O"},{"Metabolite":"Deoxycytidine","Match":"Deoxycytidine","name":"Deoxycytidine","HMDB":"HMDB0000014","PubChem":"13711","ChEBI":"15698","KEGG":"C00881","METLIN":"3367","SMILES":"NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](CO)O1"},{"Metabolite":"Deoxycytidine Monophosphate (dCMP)","Match":"dCMP","name":"dCMP","HMDB":"HMDB0001202","PubChem":"13945","ChEBI":"15918","KEGG":"C00239","METLIN":"6078","SMILES":"NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1"},{"Metabolite":"Deoxycytidine-Diphosphate (dCDP)","Match":"dCDP","name":"dCDP","HMDB":"HMDB0001245","PubChem":"150855","ChEBI":"28846","KEGG":"C00705","METLIN":"6105","SMILES":"NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O1"},{"Metabolite":"Deoxyguanosine","Match":"Deoxyguanosine","name":"Deoxyguanosine","HMDB":"HMDB0000085","PubChem":"187790","ChEBI":"17172","KEGG":"C00330","METLIN":"3395","SMILES":"NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)N1"},{"Metabolite":"Deoxyguanosine diphosphate (dGDP)","Match":"dGDP","name":"dGDP","HMDB":"HMDB0000960","PubChem":"439220","ChEBI":"28862","KEGG":"C00361","METLIN":"5906","SMILES":"NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O2)C(=O)N1"},{"Metabolite":"Deoxyguanosine triphosphate (dGTP)","Match":"dGTP","name":"dGTP","HMDB":"HMDB0001440","PubChem":"65103","ChEBI":"16497","KEGG":"C00286","METLIN":"6248","SMILES":"NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)N1"},{"Metabolite":"Deoxyguanosine-Monophosphate (dGMP)","Match":"dGMP","name":"dGMP","HMDB":"HMDB0001044","PubChem":"65059","ChEBI":"16192","KEGG":"C00362","METLIN":"NA","SMILES":"NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)C(=O)N1"},{"Metabolite":"Deoxyribose","Match":"Deoxyribose","name":"Deoxyribose","HMDB":"HMDB0003224","PubChem":"22833604","ChEBI":"28816","KEGG":"C01801","METLIN":"3258","SMILES":"OC[C@@H]1O[C@H](O)C[C@H]1O"},{"Metabolite":"Deoxyuridine","Match":"Deoxyuridine","name":"Deoxyuridine","HMDB":"HMDB0000012","PubChem":"13712","ChEBI":"16450","KEGG":"C00526","METLIN":"5086","SMILES":"OC[C@H]1O[C@H](C[C@@H]1O)N1C=CC(=O)NC1=O"},{"Metabolite":"Dethiobiotin","Match":"Dethiobiotin","name":"Dethiobiotin","HMDB":"HMDB0003581","PubChem":"445027","ChEBI":"42280","KEGG":"C01909","METLIN":"3351","SMILES":"C[C@H]1[C@H](NC(=O)N1)CCCCCC(=O)O"},{"Metabolite":"D-Glucosamine 6-phosphate","Match":"Glucosamine 6-phosphate","name":"Glucosamine 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acid","HMDB":"HMDB0000301","PubChem":"736715","ChEBI":"30817","KEGG":"C00785","METLIN":"298","SMILES":"OC(=O)C=CC1=CNC=N1"},{"Metabolite":"Valine","Match":"L-Valine","name":"L-Valine","HMDB":"HMDB0000883","PubChem":"6287","ChEBI":"16414","KEGG":"C00183","METLIN":"5842","SMILES":"CC(C)[C@H](N)C(O)=O"},{"Metabolite":"Xanthosine","Match":"Xanthosine","name":"Xanthosine","HMDB":"HMDB0000299","PubChem":"64959","ChEBI":"18107","KEGG":"C01762","METLIN":"3408","SMILES":"OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=C(O)N=C2O"},{"Metabolite":"Xanthosine-Monophosphate","Match":"NA","name":"Xanthosine-Monophosphate","HMDB":"NA","PubChem":"NA","ChEBI":"NA","KEGG":"NA","METLIN":"NA","SMILES":"NA"},{"Metabolite":"Xanthurenate","Match":"Xanthurenic acid","name":"Xanthurenic acid","HMDB":"HMDB0000881","PubChem":"5699","ChEBI":"10072","KEGG":"C02470","METLIN":"5841","SMILES":"OC(=O)C1=NC2=C(O)C=CC=C2C(O)=C1"},{"Metabolite":"Ximeninic Acid","Match":"Ximenynic acid","name":"Ximenynic 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-IS","name":"Lactate -IS","HMDB":"NA","PubChem":"NA","ChEBI":"NA","KEGG":"NA","METLIN":"NA","SMILES":"NA"},{"Metabolite":"Mannitol/Sorbitol","Match":"Mannitol/Sorbitol","name":"Mannitol/Sorbitol","HMDB":"NA","PubChem":"NA","ChEBI":"NA","KEGG":"NA","METLIN":"NA","SMILES":"NA"},{"Metabolite":"Pyruvate - IS","Match":"Pyruvate - IS","name":"Pyruvate - IS","HMDB":"NA","PubChem":"NA","ChEBI":"NA","KEGG":"NA","METLIN":"NA","SMILES":"NA"},{"Metabolite":"Threitol","Match":"Erythritol & Erythritol","name":"Erythritol & Erythritol","HMDB":"NA","PubChem":"NA","ChEBI":"NA","KEGG":"NA","METLIN":"NA","SMILES":"NA"},{"Metabolite":"Sedoheptulose-7-phosphate (D)","Match":"Sedoheptulose-7-phosphate","name":"Sedoheptulose-7-phosphate","HMDB":"NA","PubChem":"NA","ChEBI":"NA","KEGG":"NA","METLIN":"NA","SMILES":"NA"},{"Metabolite":"3-Methyl-2-Oxovalerate","Match":"3-Methyl-2-Oxovalerate & Ketoleucine","name":"3-Methyl-2-Oxovalerate & Ketoleucine","HMDB":"NA","PubChem":"NA","ChEBI":"NA","KEGG":"NA","METLIN":"NA","SMILES":"NA"}]
}
}