{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002461","ANALYSIS_ID":"AN004015","VERSION":"1","CREATED_ON":"03-17-2023"},

"PROJECT":{"PROJECT_TITLE":"Untargeted metabolomics of HUVECs subject to hypoxia/reoxygenation","PROJECT_SUMMARY":"Metabolomics analysis was performed on HUVECs subjected to hypoxia-reoxygenation to investigate metabolic alterations caused by this perturbation.","INSTITUTE":"Tulane University","DEPARTMENT":"Surgery","LABORATORY":"Tulane Trauma and Critical Care Research Lab","LAST_NAME":"Jackson-Weaver","FIRST_NAME":"Olan","ADDRESS":"1430 Tulane Ave, Department of Surgery, School of Medicine, New Orleans, LA, 70112, USA","EMAIL":"ojacksonweaver@tulane.edu","PHONE":"5049885111","DOI":"http://dx.doi.org/10.21228/M8F71Q"},

"STUDY":{"STUDY_TITLE":"Untargeted metabolomics of HUVECs subjected to hypoxia-reoxygenation","STUDY_SUMMARY":"Acute hemorrhage commonly leads to coagulopathy and organ dysfunction or failure. Recent evidence suggests that damage to the endothelial glycocalyx contributes to these adverse outcomes. The physiological events mediating acute glycocalyx shedding are undefined, however. Here, we show that succinate accumulation within endothelial cells drives glycocalyx degradation through a membrane reorganization-mediated mechanism. We investigated this mechanism in a cultured endothelial cell hypoxia-reoxygenation model, in a rat model of hemorrhage, and in trauma patient plasma samples. We found that succinate metabolism by succinate dehydrogenase mediates glycocalyx damage through lipid oxidation and phospholipase A2-mediated membrane reorganization (increasing lysophospholipids), promoting the interaction of MMP24 and MMP25 with glycocalyx constituents. In trauma patients, we found that succinate levels were associated with glycocalyx damage and the development of coagulopathy, and that interaction of MMP24 and syndecan-1 were elevated compared to healthy controls. This establishes a novel metabolic cascade mediating the endotheliopathy of traumatic hemorrhage.","INSTITUTE":"Tulane University School of Medicine","DEPARTMENT":"Surgery","LABORATORY":"Tulane Trauma and Critical Care Research Lab","LAST_NAME":"Jackson-Weaver","FIRST_NAME":"Olan","ADDRESS":"1430 Tulane Ave, Department of Surgery, School of Medicine","EMAIL":"ojacksonweaver@tulane.edu","PHONE":"5049885111","SUBMIT_DATE":"2023-01-30"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"HR1",
"Factors":{"Treatment":"hypoxia/reoxygenation"}
},
{
"Subject ID":"-",
"Sample ID":"HR2",
"Factors":{"Treatment":"hypoxia/reoxygenation"}
},
{
"Subject ID":"-",
"Sample ID":"HR3",
"Factors":{"Treatment":"hypoxia/reoxygenation"}
},
{
"Subject ID":"-",
"Sample ID":"HR4",
"Factors":{"Treatment":"hypoxia/reoxygenation"}
},
{
"Subject ID":"-",
"Sample ID":"HR5",
"Factors":{"Treatment":"hypoxia/reoxygenation"}
},
{
"Subject ID":"-",
"Sample ID":"HR6",
"Factors":{"Treatment":"hypoxia/reoxygenation"}
},
{
"Subject ID":"-",
"Sample ID":"N1",
"Factors":{"Treatment":"normoxia"}
},
{
"Subject ID":"-",
"Sample ID":"N2",
"Factors":{"Treatment":"normoxia"}
},
{
"Subject ID":"-",
"Sample ID":"N3",
"Factors":{"Treatment":"normoxia"}
},
{
"Subject ID":"-",
"Sample ID":"N4",
"Factors":{"Treatment":"normoxia"}
},
{
"Subject ID":"-",
"Sample ID":"N5",
"Factors":{"Treatment":"normoxia"}
},
{
"Subject ID":"-",
"Sample ID":"N6",
"Factors":{"Treatment":"normoxia"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"HUVECs were grown to confluence and subjected to normoxia or hypoxia (2% oxygen for 30 minutes) followed by reoxygenation for 30 minutes. Cells were washed with PBS and scraped from the plates. They were then flash frozen and saved for analysis.","COLLECTION_PROTOCOL_FILENAME":"HUVECmetabolomics.docx","SAMPLE_TYPE":"Endothelial cells","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"Cells were subjected to either normoxia or 30 minutes of hypoxia (2%) followed by 30 minutes of reoxygenation."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Samples were thawed and add with 800μL of 80% methanol, vortexed for 30 s. Then all samples were extracted at 4°C with ultrasound for 30 mins, kept at -40°C for 1 h, and centrifuged at 12000 rpm and 4°C for 15 mins. Finally, supernatant dried down under a nitrogen gas, the residue was resuspended with 100μL of 80% methanol and 5μL of DL-o-Chlorophenylalanine (140μg/mL) for LC-MS analysis."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Separation is performed by Ultimate 3000LC combined with Q Exactive MS (Thermo) and screened with ESI-MS. The LC system is comprised of an ACQUITY UPLC HSS T3 (100×2.1mm 1.8 μm) with Ultimate 3000LC. The mobile phase is composed of solvent A (0.05% formic acid-water) and solvent B (acetonitrile) with a gradient elution (0-1 min, 5% B; 1-12 min, 5-95% B; 12-13.5 min, 95% B; 13.5-13.6 min, 95-5% B; 13.6-16.0 min, 5% B). The flow rate of the mobile phase is 0.3 mL·min-1 . The column temperature is maintained at 40°C, and the sample manager temperature is set at 4°C. Mass spectrometry parameters in ESI+ and ESI- mode are listed as follows: ESI+: Heater Temp 300 °C; Sheath Gas Flow rate, 45 arb; Aux Gas Flow Rate, 15 arb; Sweep Gas Flow Rate, 1 arb; spray voltage, 3.0 kV; Capillary Temp, 350 °C; S-Lens RF Level, 30%. ESI-: Heater Temp 300 °C, Sheath Gas Flow rate, 45 arb; Aux Gas Flow Rate, 15arb; Sweep Gas Flow Rate, 1 arb; spray voltage, 3.2 kV; Capillary Temp,350 °C; S-Lens RF Level, 60%.","INSTRUMENT_NAME":"Ultimate 3000LC (Thermo)","COLUMN_NAME":"Waters ACQUITY UPLC HSS CN (100 x 2.1mm,1.8um)","COLUMN_TEMPERATURE":"40°C","FLOW_GRADIENT":"0-1 min, 5% B; 1-12 min, 5-95% B; 12-13.5 min, 95% B; 13.5-13.6 min, 95-5% B; 13.6-16.0 min, 5% B","FLOW_RATE":"0.3 mL·min-1","SOLVENT_A":"100% water; 0.05% formic acid","SOLVENT_B":"100% acetonitrile","CHROMATOGRAPHY_TYPE":"Normal phase"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Single quadrupole","MS_TYPE":"ESI","MS_COMMENTS":"ESI+: Heater Temp 300 °C; Sheath Gas Flow rate, 45 arb; Aux Gas Flow Rate, 15 arb; Sweep Gas Flow Rate, 1 arb; spray voltage, 3.0 kV; Capillary Temp, 350 °C; S-Lens RF Level, 30%.","ION_MODE":"POSITIVE"},

"MS_METABOLITE_DATA":{
"Units":"Peak area",

"Data":[{"Metabolite":"12_13-EpOME","HR1":"77.6215","HR2":"38.0921","HR3":"67.4289","HR4":"29.5588","HR5":"23.9175","HR6":"31.9079","N1":"40.2791","N2":"28.3055","N3":"27.2877","N4":"17.2565","N5":"105.4424","N6":"26.6700"},{"Metabolite":"12S-HHT","HR1":"12.7880","HR2":"11.6456","HR3":"10.3978","HR4":"12.5726","HR5":"8.7939","HR6":"11.2592","N1":"5.5741","N2":"16.8615","N3":"11.7637","N4":"6.7880","N5":"12.5533","N6":"6.2087"},{"Metabolite":"1-Methylxanthine","HR1":"544.7807","HR2":"499.1133","HR3":"39.9921","HR4":"438.3746","HR5":"543.1897","HR6":"580.2570","N1":"374.8671","N2":"1026.1918","N3":"551.3754","N4":"398.8580","N5":"709.3798","N6":"123.0332"},{"Metabolite":"27-Norcholestanehexol","HR1":"0.8604","HR2":"0.9255","HR3":"1.0892","HR4":"81.3527","HR5":"0.9288","HR6":"79.0923","N1":"24.7676","N2":"242.2539","N3":"3.5093","N4":"151.5831","N5":"1.1839","N6":"108.4744"},{"Metabolite":"2^-Deoxyguanosine 5^-monophosphate","HR1":"23.2463","HR2":"47.8356","HR3":"13.3660","HR4":"6.1649","HR5":"35.3063","HR6":"2.7685","N1":"58.6448","N2":"3.4061","N3":"49.5021","N4":"1.7240","N5":"66.7634","N6":"0.4923"},{"Metabolite":"2-Propenyl cyclohexanebutanoate","HR1":"213.7988","HR2":"259.8495","HR3":"288.0954","HR4":"837.6651","HR5":"403.9447","HR6":"938.9413","N1":"1466.8451","N2":"593.6768","N3":"362.5854","N4":"1051.0229","N5":"338.9001","N6":"889.4331"},{"Metabolite":"3-Methyl sulfolene","HR1":"1992.2402","HR2":"2061.4753","HR3":"1169.8687","HR4":"1710.9487","HR5":"1548.7471","HR6":"1720.6213","N1":"2298.3017","N2":"1779.1716","N3":"2535.5977","N4":"1111.7793","N5":"3159.2848","N6":"973.0435"},{"Metabolite":"3-Oxohexadecanoic acid","HR1":"51.4742","HR2":"34.0006","HR3":"35.1671","HR4":"45.0684","HR5":"51.1906","HR6":"41.0575","N1":"78.9075","N2":"72.6582","N3":"57.4550","N4":"36.3668","N5":"29.2143","N6":"31.0565"},{"Metabolite":"3-Oxooctadecanoic acid","HR1":"16.9433","HR2":"39.3040","HR3":"26.8291","HR4":"110.7592","HR5":"26.8680","HR6":"96.9344","N1":"25.8088","N2":"107.9183","N3":"36.1208","N4":"129.3123","N5":"23.4384","N6":"141.0250"},{"Metabolite":"3-Phosphoglyceric acid","HR1":"120.1977","HR2":"128.1382","HR3":"87.8315","HR4":"101.7547","HR5":"62.1873","HR6":"136.7134","N1":"81.5947","N2":"316.3258","N3":"113.9977","N4":"126.0946","N5":"188.6397","N6":"104.8364"},{"Metabolite":"4-Hydroxycitrulline","HR1":"9.1175","HR2":"10.9722","HR3":"7.5310","HR4":"9.5938","HR5":"6.9813","HR6":"16.9990","N1":"7.4853","N2":"8.3092","N3":"8.9036","N4":"6.8243","N5":"11.9289","N6":"8.4597"},{"Metabolite":"4-Trimethylammoniobutanoic acid","HR1":"350.4716","HR2":"379.2147","HR3":"314.1009","HR4":"266.3367","HR5":"260.4873","HR6":"342.6992","N1":"167.9315","N2":"183.3207","N3":"342.8669","N4":"208.0281","N5":"354.1524","N6":"234.1617"},{"Metabolite":"Adenosine","HR1":"13.3735","HR2":"14.1660","HR3":"7.4229","HR4":"92.1346","HR5":"22.6994","HR6":"16.3562","N1":"12.7611","N2":"22.9010","N3":"33.9535","N4":"53.5328","N5":"32.3968","N6":"61.0103"},{"Metabolite":"Alpha-Linolenoyl ethanolamide","HR1":"23.6859","HR2":"21.6501","HR3":"21.9966","HR4":"20.3977","HR5":"22.1631","HR6":"22.7284","N1":"98.2856","N2":"67.6306","N3":"64.5421","N4":"53.3379","N5":"35.0339","N6":"42.2673"},{"Metabolite":"Amidosulfonic acid","HR1":"75.6905","HR2":"63.1655","HR3":"70.4388","HR4":"88.8038","HR5":"76.0545","HR6":"93.5937","N1":"76.8031","N2":"92.1276","N3":"62.4932","N4":"112.6582","N5":"88.7886","N6":"104.2326"},{"Metabolite":"Arachidonic acid","HR1":"39.4252","HR2":"59.4124","HR3":"37.1288","HR4":"40.3321","HR5":"44.4964","HR6":"43.2051","N1":"75.8642","N2":"45.4052","N3":"70.1218","N4":"45.8716","N5":"109.4125","N6":"36.6950"},{"Metabolite":"Aspartyl-Leucine","HR1":"132.9576","HR2":"147.9220","HR3":"78.1524","HR4":"66.3065","HR5":"112.6706","HR6":"54.5624","N1":"153.2001","N2":"31.3756","N3":"172.9693","N4":"38.6015","N5":"222.4652","N6":"45.4396"},{"Metabolite":"Azelaic acid","HR1":"91.5734","HR2":"62.0299","HR3":"78.1109","HR4":"72.0927","HR5":"131.6406","HR6":"52.3003","N1":"72.3538","N2":"77.1910","N3":"113.4176","N4":"70.0511","N5":"86.6765","N6":"71.4804"},{"Metabolite":"Benzoic acid","HR1":"688.1997","HR2":"636.6703","HR3":"740.0830","HR4":"643.7480","HR5":"520.7482","HR6":"619.4733","N1":"716.8991","N2":"713.6625","N3":"844.7487","N4":"740.2166","N5":"619.9774","N6":"729.7101"},{"Metabolite":"Cer(d18:1/16:0)","HR1":"65.6181","HR2":"76.0583","HR3":"68.8901","HR4":"101.0974","HR5":"4.4796","HR6":"62.2137","N1":"3.1025","N2":"186.1783","N3":"174.4330","N4":"129.6989","N5":"82.6894","N6":"44.5761"},{"Metabolite":"Cinnamic acid","HR1":"6615.8497","HR2":"11593.8315","HR3":"10137.0625","HR4":"4367.8096","HR5":"6010.8803","HR6":"5914.2245","N1":"7306.2204","N2":"10998.1471","N3":"18271.5437","N4":"8388.9489","N5":"21619.5847","N6":"5632.5800"},{"Metabolite":"Cortisol","HR1":"25.9268","HR2":"27.6886","HR3":"37.8139","HR4":"16.9378","HR5":"36.6527","HR6":"32.5523","N1":"20.6162","N2":"64.4739","N3":"40.7262","N4":"16.7226","N5":"30.4362","N6":"44.4607"},{"Metabolite":"Creatine","HR1":"657.3333","HR2":"538.3845","HR3":"687.2413","HR4":"272.5914","HR5":"577.0940","HR6":"644.2191","N1":"389.4661","N2":"451.7194","N3":"356.2188","N4":"228.7127","N5":"258.3884","N6":"463.2203"},{"Metabolite":"Cyclohexylamine","HR1":"185.6515","HR2":"209.6555","HR3":"190.7962","HR4":"226.0057","HR5":"158.0825","HR6":"224.8756","N1":"244.5133","N2":"251.6140","N3":"289.7234","N4":"237.6921","N5":"133.9398","N6":"206.7597"},{"Metabolite":"Cytidine","HR1":"15.5866","HR2":"23.7765","HR3":"14.8545","HR4":"15.5146","HR5":"9.8219","HR6":"20.9048","N1":"6.6544","N2":"26.3814","N3":"14.3259","N4":"15.5704","N5":"24.4416","N6":"16.2445"},{"Metabolite":"Diaminopimelic acid","HR1":"41.9067","HR2":"40.0395","HR3":"41.4709","HR4":"42.1410","HR5":"42.9436","HR6":"56.1242","N1":"113.8161","N2":"121.0904","N3":"126.2306","N4":"94.6175","N5":"83.0914","N6":"62.0547"},{"Metabolite":"Dibutyl decanedioate","HR1":"116.5502","HR2":"120.9474","HR3":"127.0027","HR4":"86.7786","HR5":"590.4531","HR6":"114.9808","N1":"247.0422","N2":"192.1729","N3":"176.9103","N4":"173.8017","N5":"142.0243","N6":"121.4754"},{"Metabolite":"Diethyl phthalic acid","HR1":"43.7623","HR2":"50.5192","HR3":"44.0259","HR4":"45.1971","HR5":"69.4020","HR6":"47.7326","N1":"68.2146","N2":"62.3072","N3":"62.6930","N4":"51.2782","N5":"59.7888","N6":"81.0152"},{"Metabolite":"Dihydrolipoate","HR1":"60.1010","HR2":"83.9767","HR3":"97.9537","HR4":"65.9628","HR5":"81.9508","HR6":"95.3871","N1":"55.2299","N2":"101.5186","N3":"113.3713","N4":"94.7547","N5":"80.1878","N6":"82.3942"},{"Metabolite":"DL-o-Chlorophenylalanine","HR1":"124280.8231","HR2":"137774.4639","HR3":"156484.3974","HR4":"189446.8099","HR5":"146707.7307","HR6":"206405.5807","N1":"105019.7744","N2":"104011.4725","N3":"122897.5751","N4":"135333.4453","N5":"125304.5628","N6":"124951.5108"},{"Metabolite":"Docosahexaenoic acid","HR1":"22.1330","HR2":"23.4934","HR3":"24.6536","HR4":"38.2619","HR5":"44.0194","HR6":"32.5297","N1":"48.0660","N2":"30.1204","N3":"38.5029","N4":"42.1859","N5":"61.4098","N6":"37.5756"},{"Metabolite":"Docosanamide","HR1":"229.0978","HR2":"67.2978","HR3":"257.0507","HR4":"51.8889","HR5":"175.0102","HR6":"109.3314","N1":"290.5945","N2":"174.7006","N3":"335.9896","N4":"303.8940","N5":"103.6726","N6":"81.4096"},{"Metabolite":"Dopamine","HR1":"64.2339","HR2":"127.4732","HR3":"55.0445","HR4":"40.0125","HR5":"54.1167","HR6":"126.9001","N1":"47.4602","N2":"127.8084","N3":"164.5712","N4":"23.7707","N5":"66.2185","N6":"41.8467"},{"Metabolite":"Eicosapentaenoic acid","HR1":"27.6021","HR2":"25.4849","HR3":"26.8569","HR4":"36.5754","HR5":"22.8741","HR6":"51.5280","N1":"43.1092","N2":"40.6582","N3":"33.9312","N4":"26.8229","N5":"37.3087","N6":"45.4206"},{"Metabolite":"Glycerol 1-(5-hydroxydodecanoate)","HR1":"6.3304","HR2":"275.9028","HR3":"5.3309","HR4":"7.4155","HR5":"5.0918","HR6":"118.7165","N1":"41.2197","N2":"6.6611","N3":"6.7703","N4":"5.9604","N5":"4.5313","N6":"28.8839"},{"Metabolite":"Glycerophosphocholine","HR1":"562.7131","HR2":"653.7842","HR3":"514.7019","HR4":"455.0968","HR5":"385.0101","HR6":"696.7051","N1":"567.9172","N2":"430.5141","N3":"481.9914","N4":"797.2083","N5":"873.7727","N6":"585.7726"},{"Metabolite":"Glycyl-Phenylalanine","HR1":"64.7737","HR2":"137.0127","HR3":"84.8794","HR4":"43.5715","HR5":"97.4371","HR6":"52.7135","N1":"166.5765","N2":"18.6006","N3":"141.2430","N4":"24.0608","N5":"183.1312","N6":"40.7202"},{"Metabolite":"Guanine","HR1":"125.2106","HR2":"65.1673","HR3":"49.2617","HR4":"83.3813","HR5":"48.2211","HR6":"96.2896","N1":"74.4791","N2":"137.9658","N3":"71.1917","N4":"92.8271","N5":"94.9758","N6":"44.8453"},{"Metabolite":"Guanosine","HR1":"38.9983","HR2":"90.2791","HR3":"34.5350","HR4":"22.3266","HR5":"68.1495","HR6":"8.4466","N1":"74.0155","N2":"7.0176","N3":"51.8281","N4":"8.0267","N5":"82.6964","N6":"10.9552"},{"Metabolite":"Guanosine monophosphate","HR1":"12.3491","HR2":"26.3745","HR3":"6.3298","HR4":"3.0153","HR5":"15.6474","HR6":"0.5958","N1":"29.4922","N2":"0.7216","N3":"23.3941","N4":"0.5138","N5":"33.0782","N6":"0.4862"},{"Metabolite":"Heptylmalonic acid","HR1":"14.3204","HR2":"12.0148","HR3":"13.2361","HR4":"13.7893","HR5":"47.7000","HR6":"11.3934","N1":"11.9679","N2":"9.6739","N3":"17.2042","N4":"12.7388","N5":"14.5542","N6":"8.8750"},{"Metabolite":"Hexadecanedioic acid","HR1":"66.2268","HR2":"91.3800","HR3":"80.7444","HR4":"97.0510","HR5":"112.2376","HR6":"73.2771","N1":"100.0421","N2":"105.8763","N3":"122.6077","N4":"83.7818","N5":"93.0743","N6":"70.0543"},{"Metabolite":"Hypoxanthine","HR1":"1329.9303","HR2":"1480.0336","HR3":"1418.2457","HR4":"1138.0018","HR5":"1378.8731","HR6":"1712.5197","N1":"1010.4875","N2":"1586.9617","N3":"1565.2353","N4":"1267.2868","N5":"1405.7435","N6":"1791.5873"},{"Metabolite":"Indane","HR1":"180.8121","HR2":"173.2126","HR3":"175.4328","HR4":"183.8666","HR5":"194.0872","HR6":"254.3506","N1":"177.1240","N2":"215.6576","N3":"121.6270","N4":"147.3970","N5":"163.0292","N6":"179.6184"},{"Metabolite":"Indole","HR1":"138.4114","HR2":"115.4634","HR3":"115.5341","HR4":"129.1053","HR5":"143.3607","HR6":"152.6928","N1":"75.8727","N2":"79.6513","N3":"102.2969","N4":"96.5212","N5":"103.4150","N6":"101.3832"},{"Metabolite":"Indoleacrylic 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