{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002508","ANALYSIS_ID":"AN004130","VERSION":"1","CREATED_ON":"March 20, 2023, 7:48 am"},

"PROJECT":{"PROJECT_TITLE":"Lactate-dependent Transcriptional Regulation Controls Mammalian Eye Morphogenesis","PROJECT_SUMMARY":"Mammalian retinal metabolism favors aerobic glycolysis. However, the role of glycolytic metabolism in retinal morphogenesis remains unknown. Here we report that aerobic glycolysis is necessary for the early stages of retinal development. Taking advantage of an unbiased approach that combines the use of eye organoids and single-cell RNA sequencing we identified specific glucose transporters and glycolytic genes in retinal progenitors. Next, we determined that the optic vesicle territory of mouse embryos displays elevated levels of glycolytic activity. At the functional level, we found that removal of Glut1 (also known as Slc2a1) and Lactate dehydrogenase A (Ldha) gene activity from developing retinal progenitors arrested eye morphogenesis. Surprisingly, we uncovered that lactate-mediated upregulation of key eye-field transcription factors was controlled by the epigenetic modification of histone H3 acetylation through histone deacetylase (Hdac) activity. Our results identify a novel bioenergetic independent role of lactate as a signaling molecule necessary for mammalian eye morphogenesis.","INSTITUTE":"Northwestern University","LAST_NAME":"TAKATA","FIRST_NAME":"NOZOMU","ADDRESS":"303 East Superior Street, 10-220, Chicago, Illinois, 60611, USA","EMAIL":"nozomu.takata@northwestern.edu","PHONE":"13125036066"},

"STUDY":{"STUDY_TITLE":"13C-isotopic labeling of mouse eye organoids under three conditions.","STUDY_SUMMARY":"To examine the potential involvement of metabolites, we performed 13C-glucose labeling under three conditions: 13C-glucose = control, 13C-glucose + GNE-140 = LHDi, 13C-lactate in glucose free media mimicking the lack of glucose. Cell Name AES0145 : Rx-GFP K/I EB5 (RIKEN Cell Bank): Organoid method (PMID: 21475194).","INSTITUTE":"Northwestern University","LAST_NAME":"TAKATA","FIRST_NAME":"NOZOMU","ADDRESS":"303 East Superior Street, 10-220, Chicago, Illinois, 60611, USA","EMAIL":"nozomu.takata@northwestern.edu","PHONE":"13125036066"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"Cont1",
"Factors":{"Genotype":"Wild-type","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"Cont-biological_independent1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"Cont2",
"Factors":{"Genotype":"Wild-type","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"Cont-biological_independent2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"Cont3",
"Factors":{"Genotype":"Wild-type","Treatment":"Control"},
"Additional sample data":{"RAW_FILE_NAME":"Cont-biological_independent3.raw"}
},
{
"Subject ID":"-",
"Sample ID":"LDHi1",
"Factors":{"Genotype":"Wild-type","Treatment":"LDHi"},
"Additional sample data":{"RAW_FILE_NAME":"LDHi-biological_independent1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"LDHi2",
"Factors":{"Genotype":"Wild-type","Treatment":"LDHi"},
"Additional sample data":{"RAW_FILE_NAME":"LDHi-biological_independent2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"LDHi3",
"Factors":{"Genotype":"Wild-type","Treatment":"LDHi"},
"Additional sample data":{"RAW_FILE_NAME":"LDHi-biological_independent3.raw"}
},
{
"Subject ID":"-",
"Sample ID":"Lactate1",
"Factors":{"Genotype":"Wild-type","Treatment":"Lactate"},
"Additional sample data":{"RAW_FILE_NAME":"Lactate-biological_independent1.raw"}
},
{
"Subject ID":"-",
"Sample ID":"Lactate2",
"Factors":{"Genotype":"Wild-type","Treatment":"Lactate"},
"Additional sample data":{"RAW_FILE_NAME":"Lactate-biological_independent2.raw"}
},
{
"Subject ID":"-",
"Sample ID":"Lactate3",
"Factors":{"Genotype":"Wild-type","Treatment":"Lactate"},
"Additional sample data":{"RAW_FILE_NAME":"Lactate-biological_independent3.raw"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"The eye organoids were collected and washed twice with PBS before pellets were flash-frozen and stored at −80°C until metabolite extraction. Three biologically independent repeated samples were collected.","SAMPLE_TYPE":"Retina"},

"TREATMENT":{"TREATMENT_SUMMARY":"13C-glucose labeling under three conditions: 13C-glucose = control, 13C-glucose + GNE-140 = LHDi, 13C-lactate in glucose free media mimicking the lack of glucose. All the organoids (50 organoids per condition) were washed with blank SILAC before being reconstituted in 13C medium at a concentration of 10 eye organoids/ml."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"The eye organoids were collected and washed twice with PBS before pellets were flash-frozen and stored at −80°C until metabolite extraction. Metabolite analysis was performed as described previously (PMID: 33931446). Briefly, for metabolite extraction, 80% methanol was used followed by the rapid freeze-thaw method to break the tissues. The supernatant underwent speedvac drying. The samples were prepared in 80% acetonitrile and were analyzed by High-Resolution Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Q-exactive","COLUMN_NAME":"Waters XBridge BEH Amide (100 x 3.0mm, 3.5um)","SOLVENT_A":"95% water/5% acetonitrile; 10 mM ammonium hydroxide; 10 mM ammonium acetate, pH 9.0","SOLVENT_B":"100% acetonitrile","FLOW_GRADIENT":"0 min, 15% A; 2.5 min, 30% A; 7 min, 43% A; 16 min, 62% A; 16.1-18 min, 75% A; 18-25 min, 15% A with a flow rate of 150 μL/min","FLOW_RATE":"150 μL/mi","COLUMN_TEMPERATURE":"40"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Thermo Q Exactive Orbitrap","INSTRUMENT_TYPE":"Orbitrap","MS_TYPE":"ESI","ION_MODE":"UNSPECIFIED","MS_COMMENTS":"The capillary of the ESI source was set to 275 °C, with sheath gas at 35 arbitrary units, auxiliary gas at 5 arbitrary units and the spray voltage at 4.0 kV. In positive/negative polarity switching mode, an m/z scan range from 60 to 900 was chosen and MS1 data was collected at a resolution of 70,000. The automatic gain control (AGC) target was set at 1 × 106 and the maximum injection time was 200 ms. The top 5 precursor ions were subsequently fragmented, in a data-dependent manner, using the higher energy collisional dissociation (HCD) cell set to 30% normalized collision energy in MS2 at a resolution power of 17,500. Besides matching m/z, metabolites are identified by matching either retention time with analytical standards and/or MS2 fragmentation pattern. Data acquisition and analysis were carried out by Xcalibur 4.1 software and Tracefinder 4.1 software, respectively (both from Thermo Fisher Scientific)"},

"MS_METABOLITE_DATA":{
"Units":"Peak area",

"Data":[{"Metabolite":"Total Ion Count","Cont1":"2.74219E+11","Cont2":"1.95935E+11","Cont3":"1.65372E+11","LDHi1":"1.6884E+11","LDHi2":"2.11084E+11","LDHi3":"2.0648E+11","Lactate1":"1.94113E+11","Lactate2":"1.81327E+11","Lactate3":"1.42619E+11"},{"Metabolite":"1,3-diphosphoglycerate","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"1,3-diphosphoglycerate_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"1,3-diphosphoglycerate_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"1,3-diphosphoglycerate_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"2,3-diphosphoglycerate","Cont1":"1226510","Cont2":"235100","Cont3":"240971","LDHi1":"230944","LDHi2":"103710","LDHi3":"538598","Lactate1":"198479","Lactate2":"175908","Lactate3":"51342"},{"Metabolite":"2,3-diphosphoglycerate_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"2,3-diphosphoglycerate_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"2,3-diphosphoglycerate_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"2-HG","Cont1":"13243400","Cont2":"2834538","Cont3":"1689868","LDHi1":"1538105","LDHi2":"3170255","LDHi3":"3782099","Lactate1":"2818291","Lactate2":"2857587","Lactate3":"1359651"},{"Metabolite":"2-HG_13C1","Cont1":"840509","Cont2":"207721","Cont3":"128613","LDHi1":"147545","LDHi2":"209795","LDHi3":"227504","Lactate1":"146593","Lactate2":"215557","Lactate3":"86891"},{"Metabolite":"2-HG_13C2","Cont1":"16726","Cont2":"8390","Cont3":"7735","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"7455","Lactate3":"0"},{"Metabolite":"2-HG_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"2-HG_13C4","Cont1":"0","Cont2":"0","Cont3":"6487","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"10865","Lactate3":"0"},{"Metabolite":"2-HG_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"2/3-phosphoglycerate","Cont1":"1725483","Cont2":"98455","Cont3":"29702","LDHi1":"87255","LDHi2":"225243","LDHi3":"261978","Lactate1":"334537","Lactate2":"138670","Lactate3":"24683"},{"Metabolite":"2/3-phosphoglycerate_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"2/3-phosphoglycerate_13C2","Cont1":"147387","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"8476","Lactate3":"0"},{"Metabolite":"2/3-phosphoglycerate_13C3","Cont1":"9292473","Cont2":"113452","Cont3":"86264","LDHi1":"75360","LDHi2":"734609","LDHi3":"863373","Lactate1":"39726","Lactate2":"0","Lactate3":"0"},{"Metabolite":"3-phospho-serine","Cont1":"9742279","Cont2":"1600883","Cont3":"1538324","LDHi1":"0","LDHi2":"147606","LDHi3":"53374","Lactate1":"1789246","Lactate2":"1913503","Lactate3":"723062"},{"Metabolite":"3-phospho-serine_13C1","Cont1":"186885","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"3-phospho-serine_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"3-phospho-serine_13C3","Cont1":"2334653","Cont2":"193942","Cont3":"240759","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"6-phospho-D-gluconate","Cont1":"17189","Cont2":"7327","Cont3":"8240","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"8530"},{"Metabolite":"6-phospho-D-gluconate_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"8041","Lactate2":"0","Lactate3":"0"},{"Metabolite":"6-phospho-D-gluconate_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"6-phospho-D-gluconate_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"6-phospho-D-gluconate_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"6-phospho-D-gluconate_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"6-phospho-D-gluconate_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"acetoacetic acid / succinic semialdehyde","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"acetoacetate / succinic semialdehyde_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"acetoacetate / succinic semialdehyde_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"acetoacetate / succinic semialdehyde_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"acetoacetate / succinic semialdehyde_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"acetyl-CoA +","Cont1":"337456","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"103059","LDHi3":"24621","Lactate1":"24085","Lactate2":"36149","Lactate3":"0"},{"Metabolite":"acetyl-CoA_13C1 +","Cont1":"23780","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"acetyl-CoA_13C2 +","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"aconitic acid -","Cont1":"7116027","Cont2":"882294","Cont3":"602630","LDHi1":"22215","LDHi2":"603661","LDHi3":"607416","Lactate1":"903682","Lactate2":"1184024","Lactate3":"346964"},{"Metabolite":"aconitic acid_13C1 -","Cont1":"368771","Cont2":"13707","Cont3":"9983","LDHi1":"0","LDHi2":"35236","LDHi3":"18312","Lactate1":"39213","Lactate2":"42750","Lactate3":"7673"},{"Metabolite":"aconitic acid_13C2 -","Cont1":"354232","Cont2":"10168","Cont3":"0","LDHi1":"0","LDHi2":"22906","LDHi3":"14270","Lactate1":"222770","Lactate2":"259612","Lactate3":"53499"},{"Metabolite":"adenosine","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"1226746","LDHi2":"1396334","LDHi3":"1801876","Lactate1":"1803995","Lactate2":"1736962","Lactate3":"1692871"},{"Metabolite":"adenosine_13C10","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"adenosine_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"adenosine_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"adenosine_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"adenosine_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"adenosine_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ADP / dGDP","Cont1":"18582485","Cont2":"2930296","Cont3":"3549412","LDHi1":"5225530","LDHi2":"11353928","LDHi3":"9651870","Lactate1":"9349445","Lactate2":"9178396","Lactate3":"3476648"},{"Metabolite":"ADP / dGDP_13C1","Cont1":"1728097","Cont2":"63717","Cont3":"71288","LDHi1":"148462","LDHi2":"897870","LDHi3":"841679","Lactate1":"687118","Lactate2":"664976","Lactate3":"119877"},{"Metabolite":"ADP / dGDP_13C10","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ADP / dGDP_13C2","Cont1":"174343","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"18131","LDHi3":"18851","Lactate1":"20094","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ADP / dGDP_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ADP / dGDP_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ADP / dGDP_13C5","Cont1":"1175920","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ADP / dGDP_13C6","Cont1":"35484","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ADP / dGDP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ADP / dGDP_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ADP / dGDP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"AICAR","Cont1":"819862","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"AICAR_13C5","Cont1":"4801188","Cont2":"411821","Cont3":"227457","LDHi1":"0","LDHi2":"17595","LDHi3":"0","Lactate1":"19148","Lactate2":"0","Lactate3":"0"},{"Metabolite":"AICAR_13C6","Cont1":"135065","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"AICAR_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"AICAR_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"AICAR_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"a-KG","Cont1":"15022110","Cont2":"2296224","Cont3":"2031671","LDHi1":"407652","LDHi2":"937684","LDHi3":"931284","Lactate1":"1414650","Lactate2":"1827767","Lactate3":"590097"},{"Metabolite":"a-KG_13C1","Cont1":"698540","Cont2":"65145","Cont3":"80590","LDHi1":"0","LDHi2":"15245","LDHi3":"0","Lactate1":"46663","Lactate2":"71015","Lactate3":"10178"},{"Metabolite":"a-KG_13C2","Cont1":"188026","Cont2":"0","Cont3":"0","LDHi1":"105020","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"a-KG_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"a-KG_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"a-KG_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"alanine","Cont1":"25065233","Cont2":"6517719","Cont3":"3578383","LDHi1":"7362929","LDHi2":"14326378","LDHi3":"12874303","Lactate1":"5414129","Lactate2":"6190067","Lactate3":"2278860"},{"Metabolite":"alanine_13C1","Cont1":"796647","Cont2":"294508","Cont3":"273287","LDHi1":"237877","LDHi2":"561984","LDHi3":"340258","Lactate1":"224690","Lactate2":"112041","Lactate3":"167165"},{"Metabolite":"alanine_13C2","Cont1":"537997","Cont2":"92012","Cont3":"43712","LDHi1":"61594","LDHi2":"204301","LDHi3":"151978","Lactate1":"58044","Lactate2":"52413","Lactate3":"6592"},{"Metabolite":"alanine_13C3","Cont1":"21203179","Cont2":"3388168","Cont3":"2344610","LDHi1":"3381440","LDHi2":"8020927","LDHi3":"6577821","Lactate1":"2148662","Lactate2":"2439866","Lactate3":"932416"},{"Metabolite":"AMP / dGMP","Cont1":"9836118","Cont2":"3574625","Cont3":"2547477","LDHi1":"7757264","LDHi2":"15889849","LDHi3":"14808144","Lactate1":"3788059","Lactate2":"3250957","Lactate3":"1872121"},{"Metabolite":"AMP / dGMP_13C1","Cont1":"597068","Cont2":"68125","Cont3":"0","LDHi1":"520316","LDHi2":"1381246","LDHi3":"1451389","Lactate1":"95911","Lactate2":"95668","Lactate3":"0"},{"Metabolite":"AMP / dGMP_13C10","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"AMP / dGMP_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"19560","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"AMP / dGMP_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"AMP / dGMP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"AMP / dGMP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"AMP / dGMP_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"AMP / dGMP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"aspartate","Cont1":"305091751","Cont2":"47212147","Cont3":"31202601","LDHi1":"23365663","LDHi2":"54054525","LDHi3":"49652023","Lactate1":"115701962","Lactate2":"121280032","Lactate3":"42549526"},{"Metabolite":"aspartate_13C1","Cont1":"14458310","Cont2":"1231801","Cont3":"1102132","LDHi1":"683906","LDHi2":"1737434","LDHi3":"1043317","Lactate1":"2727759","Lactate2":"2818576","Lactate3":"788307"},{"Metabolite":"aspartate_13C2","Cont1":"1477780","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"2804206","Lactate2":"2749085","Lactate3":"1001279"},{"Metabolite":"aspartate_13C3","Cont1":"14458310","Cont2":"1293277","Cont3":"1097233","LDHi1":"605026","LDHi2":"1737434","LDHi3":"898304","Lactate1":"2727759","Lactate2":"2818576","Lactate3":"851531"},{"Metabolite":"aspartate_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ATP / dGTP","Cont1":"4123943","Cont2":"2555567","Cont3":"3013567","LDHi1":"1238904","LDHi2":"1355675","LDHi3":"1078400","Lactate1":"3917949","Lactate2":"6164116","Lactate3":"2836009"},{"Metabolite":"ATP / dGTP_13C10","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ATP / dGTP_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ATP / dGTP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ATP / dGTP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ATP / dGTP_13C8","Cont1":"252855","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"ATP / dGTP_13C9","Cont1":"16581","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"choline+","Cont1":"9981125","Cont2":"10446513","Cont3":"10697606","LDHi1":"9861465","LDHi2":"9201055","LDHi3":"10044140","Lactate1":"9972884","Lactate2":"9802173","Lactate3":"8116464"},{"Metabolite":"choline_13C1+","Cont1":"4017052","Cont2":"143204","Cont3":"189675","LDHi1":"147494","LDHi2":"59705","LDHi3":"71205","Lactate1":"140186","Lactate2":"73131","Lactate3":"136406"},{"Metabolite":"choline_13C2+","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"choline_13C3+","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"choline_13C4+","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"choline_13C5+","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"citrate(iso)/citrate","Cont1":"36431171","Cont2":"6402465","Cont3":"3414691","LDHi1":"2307455","LDHi2":"16204254","LDHi3":"13795512","Lactate1":"14209609","Lactate2":"2733962","Lactate3":"1536719"},{"Metabolite":"citrate(iso)/citrate_13C1","Cont1":"2104973","Cont2":"170757","Cont3":"0","LDHi1":"8959","LDHi2":"863876","LDHi3":"754969","Lactate1":"756752","Lactate2":"40582","Lactate3":"7335"},{"Metabolite":"citrate(iso)/citrate_13C2","Cont1":"319434","Cont2":"34429","Cont3":"0","LDHi1":"9031","LDHi2":"140533","LDHi3":"138743","Lactate1":"764541","Lactate2":"40964","Lactate3":"0"},{"Metabolite":"citrate(iso)/citrate_13C3","Cont1":"0","Cont2":"9531","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"11541","Lactate2":"0","Lactate3":"0"},{"Metabolite":"citrate(iso)/citrate_13C4","Cont1":"0","Cont2":"7084","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"8206"},{"Metabolite":"citrate(iso)/citrate_13C5","Cont1":"0","Cont2":"0","Cont3":"8542","LDHi1":"10145","LDHi2":"7340","LDHi3":"11422","Lactate1":"8213","Lactate2":"0","Lactate3":"0"},{"Metabolite":"citrate(iso)/citrate_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"8469","Lactate3":"0"},{"Metabolite":"CMP","Cont1":"7400240","Cont2":"1000633","Cont3":"673348","LDHi1":"2401071","LDHi2":"5648886","LDHi3":"4835005","Lactate1":"1865382","Lactate2":"1829868","Lactate3":"567419"},{"Metabolite":"CMP_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"CMP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"CMP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"CMP_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"20389","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"CMP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"Crotonyl-CoA","Cont1":"26537","Cont2":"0","Cont3":"15540","LDHi1":"17705","LDHi2":"22028","LDHi3":"0","Lactate1":"24605","Lactate2":"0","Lactate3":"0"},{"Metabolite":"CTP","Cont1":"9521665","Cont2":"1568254","Cont3":"1854123","LDHi1":"414172","LDHi2":"895014","LDHi3":"818830","Lactate1":"2840692","Lactate2":"4140015","Lactate3":"963334"},{"Metabolite":"CTP_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"CTP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"CTP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"CTP_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"CTP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"cystathionine","Cont1":"3695618","Cont2":"3533037","Cont3":"2964077","LDHi1":"3261146","LDHi2":"5096524","LDHi3":"3619768","Lactate1":"4042573","Lactate2":"5158438","Lactate3":"2364758"},{"Metabolite":"cystathionine_13C1","Cont1":"0","Cont2":"0","Cont3":"18711","LDHi1":"70892","LDHi2":"81561","LDHi3":"0","Lactate1":"0","Lactate2":"21001","Lactate3":"0"},{"Metabolite":"cysteine","Cont1":"12299477","Cont2":"3200830","Cont3":"2030043","LDHi1":"1149913","LDHi2":"1819137","LDHi3":"1552471","Lactate1":"2807781","Lactate2":"2963836","Lactate3":"968797"},{"Metabolite":"cysteine_13C1","Cont1":"339724","Cont2":"23257","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"29696","Lactate2":"34541","Lactate3":"0"},{"Metabolite":"cysteine_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"cysteine_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dATP","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dATP_13C10","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dATP_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dATP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dATP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dATP_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dATP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dCTP","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dCTP_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dCTP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dCTP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dCTP_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dCTP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"deoxyguanosine","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"deoxyguanosine_13C10","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"deoxyguanosine_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"deoxyguanosine_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"deoxyguanosine_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"deoxyguanosine_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"deoxyguanosine_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"D-galactosamine/glucosamine-1/6-phosphate","Cont1":"1014058","Cont2":"129212","Cont3":"82001","LDHi1":"164324","LDHi2":"306835","LDHi3":"350058","Lactate1":"142716","Lactate2":"264690","Lactate3":"48195"},{"Metabolite":"D-galactosamine/glucosamine-1/6-phosphate_13C6","Cont1":"146329","Cont2":"0","Cont3":"0","LDHi1":"72545","LDHi2":"441050","LDHi3":"212788","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GAP / DHAP","Cont1":"72491","Cont2":"0","Cont3":"6004","LDHi1":"16601","LDHi2":"93921","LDHi3":"86425","Lactate1":"16089","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GAP / DHAP_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GAP / DHAP_13C2","Cont1":"96642","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"107042","LDHi3":"77898","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GAP / DHAP_13C3","Cont1":"8147722","Cont2":"1549561","Cont3":"705858","LDHi1":"2247197","LDHi2":"6141906","LDHi3":"4688137","Lactate1":"555480","Lactate2":"530691","Lactate3":"174451"},{"Metabolite":"D-ribose-1/5-phosphate","Cont1":"842268","Cont2":"46602","Cont3":"28329","LDHi1":"64352","LDHi2":"290087","LDHi3":"247252","Lactate1":"63555","Lactate2":"58998","Lactate3":"16200"},{"Metabolite":"D-ribose-1/5-phosphate_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"D-ribose-1/5-phosphate_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"D-ribose-1/5-phosphate_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"16603","LDHi3":"25854","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"D-ribose-1/5-phosphate_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"D-ribose-1/5-phosphate_13C5","Cont1":"316114","Cont2":"7861","Cont3":"0","LDHi1":"34968","LDHi2":"238824","LDHi3":"183847","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"D-sedoheptulose-7-phosphate","Cont1":"539008","Cont2":"27745","Cont3":"8497","LDHi1":"0","LDHi2":"124575","LDHi3":"79776","Lactate1":"107880","Lactate2":"48116","Lactate3":"0"},{"Metabolite":"D-sedoheptulose-7-phosphate_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"D-sedoheptulose-7-phosphate_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"D-sedoheptulose-7-phosphate_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"D-sedoheptulose-7-phosphate_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"6894","Lactate2":"0","Lactate3":"0"},{"Metabolite":"D-sedoheptulose-7-phosphate_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"D-sedoheptulose-7-phosphate_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"D-sedoheptulose-7-phosphate_13C7","Cont1":"289871","Cont2":"0","Cont3":"0","LDHi1":"9887","LDHi2":"158037","LDHi3":"122612","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dTTP","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"12542","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dTTP_13C10","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dTTP_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dTTP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dTTP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dTTP_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dTTP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dUTP","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dUTP_13C5","Cont1":"179963","Cont2":"109105","Cont3":"0","LDHi1":"0","LDHi2":"108233","LDHi3":"100288","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dUTP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"27249","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dUTP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dUTP_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"dUTP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"21986","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"F-1,6/2,6-P","Cont1":"3392276","Cont2":"1135815","Cont3":"1127005","LDHi1":"1214554","LDHi2":"1196574","LDHi3":"1109361","Lactate1":"561993","Lactate2":"302781","Lactate3":"183487"},{"Metabolite":"F-1,6/2,6-P_13C1","Cont1":"43152","Cont2":"7498","Cont3":"6294","LDHi1":"0","LDHi2":"7632","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"F-1,6/2,6-P_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"15077","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"F-1,6/2,6-P_13C3","Cont1":"25550","Cont2":"0","Cont3":"0","LDHi1":"281538","LDHi2":"1760279","LDHi3":"1410021","Lactate1":"31162","Lactate2":"0","Lactate3":"0"},{"Metabolite":"F-1,6/2,6-P_13C4","Cont1":"7827","Cont2":"0","Cont3":"0","LDHi1":"6631","LDHi2":"106474","LDHi3":"143805","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"F-1,6/2,6-P_13C5","Cont1":"329258","Cont2":"8136","Cont3":"0","LDHi1":"501855","LDHi2":"1746807","LDHi3":"1545972","Lactate1":"48163","Lactate2":"0","Lactate3":"0"},{"Metabolite":"F-1,6/2,6-P_13C6","Cont1":"7547299","Cont2":"1742326","Cont3":"1267705","LDHi1":"7609010","LDHi2":"18114025","LDHi3":"26153553","Lactate1":"4123345","Lactate2":"1554816","Lactate3":"865772"},{"Metabolite":"fructose / mannose","Cont1":"1673989","Cont2":"557788","Cont3":"276736","LDHi1":"384629","LDHi2":"865797","LDHi3":"784827","Lactate1":"476957","Lactate2":"479910","Lactate3":"313170"},{"Metabolite":"fumarate","Cont1":"9244783","Cont2":"2027593","Cont3":"1655997","LDHi1":"1424563","LDHi2":"2422532","LDHi3":"2589033","Lactate1":"3160691","Lactate2":"3542559","Lactate3":"1641549"},{"Metabolite":"fumarate_13C1","Cont1":"319685","Cont2":"24033","Cont3":"41858","LDHi1":"34815","LDHi2":"85135","LDHi3":"110049","Lactate1":"118548","Lactate2":"128973","Lactate3":"44826"},{"Metabolite":"fumarate_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"26507","Lactate2":"39710","Lactate3":"0"},{"Metabolite":"fumarate_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"fumarate_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"F6P/G1P/G6P","Cont1":"1473373","Cont2":"217184","Cont3":"96482","LDHi1":"238266","LDHi2":"576783","LDHi3":"525972","Lactate1":"182414","Lactate2":"291325","Lactate3":"45995"},{"Metabolite":"F6P/G1P/G6P_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"F6P/G1P/G6P_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"F6P/G1P/G6P_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"40912","LDHi2":"174308","LDHi3":"142393","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"F6P/G1P/G6P_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"F6P/G1P/G6P_13C5","Cont1":"224268","Cont2":"14698","Cont3":"0","LDHi1":"58414","LDHi2":"279987","LDHi3":"198410","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"F6P/G1P/G6P_13C6","Cont1":"7569273","Cont2":"1185648","Cont3":"832533","LDHi1":"2732288","LDHi2":"5888819","LDHi3":"5218650","Lactate1":"NaN","Lactate2":"0","Lactate3":"0"},{"Metabolite":"galactose / glucose","Cont1":"2731847","Cont2":"1296918","Cont3":"376053","LDHi1":"689833","LDHi2":"1621080","LDHi3":"2124220","Lactate1":"589331","Lactate2":"508274","Lactate3":"463879"},{"Metabolite":"glucose_13C6","Cont1":"1022616392","Cont2":"583619356","Cont3":"184003185","LDHi1":"181940935","LDHi2":"391051946","LDHi3":"303323058","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glutamate","Cont1":"1164428382","Cont2":"260256195","Cont3":"169644273","LDHi1":"171883247","LDHi2":"371419947","LDHi3":"317905280","Lactate1":"270447701","Lactate2":"316455919","Lactate3":"115196889"},{"Metabolite":"glutamate_13C1","Cont1":"79939319","Cont2":"17107928","Cont3":"11254579","LDHi1":"11400461","LDHi2":"25001209","LDHi3":"21505146","Lactate1":"18653842","Lactate2":"21431848","Lactate3":"7789829"},{"Metabolite":"glutamate_13C2","Cont1":"9109483","Cont2":"1491961","Cont3":"909122","LDHi1":"1780665","LDHi2":"4497127","LDHi3":"3924870","Lactate1":"12988486","Lactate2":"13584278","Lactate3":"5081063"},{"Metabolite":"glutamate_13C3","Cont1":"416534","Cont2":"106546","Cont3":"67985","LDHi1":"262915","LDHi2":"191414","LDHi3":"196857","Lactate1":"646507","Lactate2":"473733","Lactate3":"244363"},{"Metabolite":"glutamate_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"86044","Lactate2":"52579","Lactate3":"15352"},{"Metabolite":"glutamate_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glutamine","Cont1":"3358403145","Cont2":"1740426364","Cont3":"646761073","LDHi1":"658155398","LDHi2":"1278119570","LDHi3":"1081467764","Lactate1":"1311364235","Lactate2":"974112581","Lactate3":"413352557"},{"Metabolite":"glutamine_13C1","Cont1":"196454125","Cont2":"99456339","Cont3":"35538514","LDHi1":"36947704","LDHi2":"71901077","LDHi3":"60652869","Lactate1":"72961103","Lactate2":"54404258","Lactate3":"22038288"},{"Metabolite":"glutamine_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glutamine_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"544419","LDHi2":"0","LDHi3":"241796","Lactate1":"383563","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glutamine_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glutamine_13C5","Cont1":"0","Cont2":"33246","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glutathione","Cont1":"331295700","Cont2":"42627620","Cont3":"47297012","LDHi1":"45199653","LDHi2":"81935212","LDHi3":"77381479","Lactate1":"46687762","Lactate2":"79458054","Lactate3":"29694821"},{"Metabolite":"glutathione_13C1","Cont1":"32911419","Cont2":"4225456","Cont3":"5075335","LDHi1":"4813954","LDHi2":"7965777","LDHi3":"7324100","Lactate1":"4849757","Lactate2":"7746692","Lactate3":"2933961"},{"Metabolite":"glutathione_13C2","Cont1":"2442994","Cont2":"116360","Cont3":"345158","LDHi1":"75052","LDHi2":"322483","LDHi3":"134674","Lactate1":"210621","Lactate2":"380473","Lactate3":"98451"},{"Metabolite":"glutathione_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glutathione_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glutathione_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glutathione disulfide","Cont1":"1368723","Cont2":"560385","Cont3":"1492262","LDHi1":"1717862","LDHi2":"1028755","LDHi3":"843039","Lactate1":"453940","Lactate2":"974957","Lactate3":"1258980"},{"Metabolite":"glutathione disulfide_13C1","Cont1":"0","Cont2":"17862","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"63123","Lactate3":"18371"},{"Metabolite":"glutathione disulfide_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glutathione disulfide_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glutathione disulfide_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glutathione disulfide_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glycerate","Cont1":"3600285","Cont2":"1083314","Cont3":"688015","LDHi1":"995269","LDHi2":"1570161","LDHi3":"2167741","Lactate1":"2714189","Lactate2":"2435107","Lactate3":"1179077"},{"Metabolite":"glycerate_13C1","Cont1":"212862","Cont2":"155576","Cont3":"148399","LDHi1":"211884","LDHi2":"122432","LDHi3":"306435","Lactate1":"198209","Lactate2":"152919","Lactate3":"53581"},{"Metabolite":"glycerate_13C2","Cont1":"33867","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glycerate_13C3","Cont1":"2444037","Cont2":"466771","Cont3":"278793","LDHi1":"219306","LDHi2":"536002","LDHi3":"371214","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glycerol-2/3-phosphate","Cont1":"1932871","Cont2":"648055","Cont3":"450930","LDHi1":"368548","LDHi2":"650785","LDHi3":"485436","Lactate1":"241896","Lactate2":"311733","Lactate3":"88035"},{"Metabolite":"glycerol-2/3-phosphate_13C2","Cont1":"0","Cont2":"0","Cont3":"10296","LDHi1":"7861","LDHi2":"0","LDHi3":"13083","Lactate1":"0","Lactate2":"7226","Lactate3":"0"},{"Metabolite":"glycerol-2/3-phosphate_13C3","Cont1":"927800","Cont2":"19274","Cont3":"25955","LDHi1":"432385","LDHi2":"1259706","LDHi3":"981191","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"glycine","Cont1":"184934967","Cont2":"52796263","Cont3":"24801421","LDHi1":"24525007","LDHi2":"57204709","LDHi3":"46955455","Lactate1":"49330644","Lactate2":"45695905","Lactate3":"16948791"},{"Metabolite":"glycine_13C1","Cont1":"2991209","Cont2":"847170","Cont3":"448865","LDHi1":"492070","LDHi2":"964965","LDHi3":"706700","Lactate1":"818840","Lactate2":"733284","Lactate3":"279327"},{"Metabolite":"glycine_13C2","Cont1":"1185463","Cont2":"210588","Cont3":"132541","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GMP","Cont1":"1182464","Cont2":"195998","Cont3":"29257","LDHi1":"1340544","LDHi2":"3326175","LDHi3":"3300893","Lactate1":"363074","Lactate2":"168299","Lactate3":"57269"},{"Metabolite":"GMP_13C10","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GMP_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GMP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GMP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GMP_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GMP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GTP","Cont1":"2859955","Cont2":"123822","Cont3":"345283","LDHi1":"56130","LDHi2":"413781","LDHi3":"411226","Lactate1":"521792","Lactate2":"953124","Lactate3":"69570"},{"Metabolite":"GTP_13C10","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GTP_13C5","Cont1":"313202","Cont2":"0","Cont3":"40016","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"16482"},{"Metabolite":"GTP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"18505","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GTP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GTP_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"GTP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"guanosine","Cont1":"13528966","Cont2":"2261203","Cont3":"1534190","LDHi1":"3758632","LDHi2":"9311364","LDHi3":"8678446","Lactate1":"2799345","Lactate2":"2911729","Lactate3":"1240997"},{"Metabolite":"guanosine_13C10","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"guanosine_13C5","Cont1":"201682","Cont2":"16698","Cont3":"0","LDHi1":"23801","LDHi2":"24645","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"guanosine_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"guanosine_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"guanosine_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"guanosine_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"22942","Lactate3":"0"},{"Metabolite":"IDP","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"IDP_13C10","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"IDP_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"IDP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"IDP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"IDP_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"15489","Lactate2":"0","Lactate3":"0"},{"Metabolite":"IDP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"IMP","Cont1":"1455630","Cont2":"318571","Cont3":"73794","LDHi1":"519857","LDHi2":"1594284","LDHi3":"1703680","Lactate1":"97441","Lactate2":"43237","Lactate3":"36556"},{"Metabolite":"IMP_13C10","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"IMP_13C5","Cont1":"665474","Cont2":"19339","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"IMP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"IMP_13C7","Cont1":"105540","Cont2":"94170","Cont3":"177684","LDHi1":"32047","LDHi2":"199181","LDHi3":"379876","Lactate1":"96080","Lactate2":"202322","Lactate3":"24197"},{"Metabolite":"IMP_13C8","Cont1":"24078","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"14000","LDHi3":"0","Lactate1":"0","Lactate2":"41356","Lactate3":"0"},{"Metabolite":"IMP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"itaconic acid","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"itaconic acid_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"itaconic acid_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"lactate","Cont1":"249202576","Cont2":"65226445","Cont3":"41286092","LDHi1":"71783986","LDHi2":"138424200","LDHi3":"108418011","Lactate1":"91407007","Lactate2":"70388425","Lactate3":"46296015"},{"Metabolite":"lactate_13C1","Cont1":"7345963","Cont2":"2416959","Cont3":"2275117","LDHi1":"2653238","LDHi2":"4276654","LDHi3":"4067520","Lactate1":"1088077","Lactate2":"1749458","Lactate3":"851124"},{"Metabolite":"lactate_13C2","Cont1":"13590376","Cont2":"4265903","Cont3":"1250352","LDHi1":"23212","LDHi2":"249312","LDHi3":"255058","Lactate1":"48348842","Lactate2":"33931414","Lactate3":"15202929"},{"Metabolite":"lactate_13C3","Cont1":"501632847","Cont2":"189199226","Cont3":"79693023","LDHi1":"11863021","LDHi2":"26831739","LDHi3":"24830137","Lactate1":"1902027763","Lactate2":"1389055916","Lactate3":"675270166"},{"Metabolite":"leucine / leucine(iso)","Cont1":"3812808335","Cont2":"2017362347","Cont3":"714350392","LDHi1":"706607658","LDHi2":"1555202330","LDHi3":"1245709682","Lactate1":"1574499307","Lactate2":"1137999514","Lactate3":"500708200"},{"Metabolite":"leucine / leucine(iso)_13C1","Cont1":"258380172","Cont2":"136024563","Cont3":"47026974","LDHi1":"47978987","LDHi2":"104223789","LDHi3":"83318178","Lactate1":"105057774","Lactate2":"76005213","Lactate3":"33309954"},{"Metabolite":"leucine / leucine(iso)_13C2","Cont1":"5284187","Cont2":"2703075","Cont3":"423278","LDHi1":"921056","LDHi2":"2143603","LDHi3":"1709757","Lactate1":"2147903","Lactate2":"689079","Lactate3":"329316"},{"Metabolite":"leucine / leucine(iso)_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"leucine / leucine(iso)_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"malate","Cont1":"1054323529","Cont2":"59379313","Cont3":"26651176","LDHi1":"17656210","LDHi2":"77382024","LDHi3":"68208412","Lactate1":"77151886","Lactate2":"123662273","Lactate3":"20301565"},{"Metabolite":"malate_13C1","Cont1":"44297151","Cont2":"2266594","Cont3":"1034021","LDHi1":"758137","LDHi2":"3024591","LDHi3":"2801424","Lactate1":"3079373","Lactate2":"3562967","Lactate3":"1124153"},{"Metabolite":"malate_13C2","Cont1":"2954319","Cont2":"698977","Cont3":"473769","LDHi1":"1715464","LDHi2":"549339","LDHi3":"1101645","Lactate1":"1952742","Lactate2":"1801307","Lactate3":"1197731"},{"Metabolite":"malate_13C3","Cont1":"12549568","Cont2":"787295","Cont3":"431189","LDHi1":"101502","LDHi2":"486523","LDHi3":"493862","Lactate1":"104755","Lactate2":"96839","Lactate3":"9444"},{"Metabolite":"malate_13C4","Cont1":"335731","Cont2":"65160","Cont3":"103970","LDHi1":"253677","LDHi2":"183738","LDHi3":"214671","Lactate1":"160739","Lactate2":"141794","Lactate3":"69055"},{"Metabolite":"mevalonate","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"mevalonate_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"mevalonate_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"mevalonate_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"mevalonate_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"mevalonate_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"mevalonate_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"N-acetyl-glucosamine-1/6-phosphate","Cont1":"504663","Cont2":"17746","Cont3":"0","LDHi1":"0","LDHi2":"85625","LDHi3":"143120","Lactate1":"52063","Lactate2":"31695","Lactate3":"8219"},{"Metabolite":"N-acetyl-glucosamine-1/6-phosphate_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"N-acetyl-glucosamine-1/6-phosphate_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"8504","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"NAD+","Cont1":"26608927","Cont2":"5107379","Cont3":"3288637","LDHi1":"3147748","LDHi2":"6933227","LDHi3":"5888028","Lactate1":"6702567","Lactate2":"7767395","Lactate3":"2832174"},{"Metabolite":"NADH","Cont1":"1876383","Cont2":"274129","Cont3":"181152","LDHi1":"1036977","LDHi2":"2451017","LDHi3":"2195392","Lactate1":"172767","Lactate2":"234527","Lactate3":"51659"},{"Metabolite":"NADP+","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"NADPH","Cont1":"197816","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"17360","Lactate3":"0"},{"Metabolite":"N-carbamoyl-L-aspartate","Cont1":"2059661","Cont2":"161778","Cont3":"88095","LDHi1":"8698","LDHi2":"17816","LDHi3":"26016","Lactate1":"72636","Lactate2":"64735","Lactate3":"9692"},{"Metabolite":"N-carbamoyl-L-aspartate_13C1","Cont1":"83000","Cont2":"0","Cont3":"9147","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"N-carbamoyl-L-aspartate_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"N-carbamoyl-L-aspartate_13C3","Cont1":"21782","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"N-carbamoyl-L-aspartate_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"N-carbamoyl-L-aspartate_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"oxaloacetate","Cont1":"76277","Cont2":"10781","Cont3":"6869","LDHi1":"9456","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"oxaloacetate_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"oxaloacetate_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"oxaloacetate_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"oxaloacetate_13C4","Cont1":"27284","Cont2":"10223","Cont3":"9775","LDHi1":"15997","LDHi2":"19312","LDHi3":"0","Lactate1":"24777","Lactate2":"6489","Lactate3":"12916"},{"Metabolite":"phosphoenolpyruvate","Cont1":"420844","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"9684","LDHi3":"17898","Lactate1":"71163","Lactate2":"10005","Lactate3":"0"},{"Metabolite":"phosphoenolpyruvate_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"phosphoenolpyruvate_13C2","Cont1":"81982","Cont2":"25877","Cont3":"19518","LDHi1":"37504","LDHi2":"65655","LDHi3":"10179","Lactate1":"12711","Lactate2":"26544","Lactate3":"32137"},{"Metabolite":"phosphoenolpyruvate_13C3","Cont1":"4264453","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"84309","LDHi3":"81154","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"PRPP","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"PRPP_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"PRPP_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"PRPP_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"PRPP_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"PRPP_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"pyruvate","Cont1":"4956383","Cont2":"1354548","Cont3":"449550","LDHi1":"1847180","LDHi2":"4651110","LDHi3":"3472176","Lactate1":"930335","Lactate2":"2628428","Lactate3":"464500"},{"Metabolite":"pyruvate_13C1","Cont1":"103787","Cont2":"44397","Cont3":"95006","LDHi1":"147168","LDHi2":"147596","LDHi3":"115938","Lactate1":"64715","Lactate2":"112021","Lactate3":"88610"},{"Metabolite":"pyruvate_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"pyruvate_13C3","Cont1":"2646044","Cont2":"704464","Cont3":"767842","LDHi1":"346287","LDHi2":"862294","LDHi3":"1224200","Lactate1":"1545582","Lactate2":"1464988","Lactate3":"509933"},{"Metabolite":"S-adenosyl-L-homoCysteine","Cont1":"3636733","Cont2":"436668","Cont3":"158877","LDHi1":"375973","LDHi2":"996632","LDHi3":"1018311","Lactate1":"813198","Lactate2":"692162","Lactate3":"254222"},{"Metabolite":"S-adenosyl-L-homoCysteine_13C1","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"30374","LDHi2":"47600","LDHi3":"71345","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"S-adenosyl-L-methionine","Cont1":"7852711","Cont2":"1129434","Cont3":"896807","LDHi1":"1096529","LDHi2":"2802215","LDHi3":"2442591","Lactate1":"1916272","Lactate2":"2040680","Lactate3":"608925"},{"Metabolite":"S-adenosyl-L-methionine_13C1","Cont1":"1346553","Cont2":"20088","Cont3":"0","LDHi1":"71613","LDHi2":"333362","LDHi3":"274302","Lactate1":"178720","Lactate2":"146500","Lactate3":"0"},{"Metabolite":"S-adenosyl-L-methionine_13C2","Cont1":"16655","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"S-adenosyl-L-methionine_13C3","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"18286"},{"Metabolite":"S-adenosyl-L-methionine_13C4","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"15042"},{"Metabolite":"S-adenosyl-L-methionine_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"35530","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"S-adenosyl-L-methionine_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"S-adenosyl-L-methionine_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"S-adenosyl-L-methionine_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"S-adenosyl-L-methionine_13C9","Cont1":"15959","Cont2":"0","Cont3":"38974","LDHi1":"25433","LDHi2":"0","LDHi3":"0","Lactate1":"19875","Lactate2":"0","Lactate3":"0"},{"Metabolite":"serine","Cont1":"184223283","Cont2":"61196392","Cont3":"27237728","LDHi1":"29886994","LDHi2":"62694576","LDHi3":"49815063","Lactate1":"50682894","Lactate2":"41047248","Lactate3":"16771491"},{"Metabolite":"serine_13C1","Cont1":"6873451","Cont2":"2036826","Cont3":"913460","LDHi1":"774342","LDHi2":"1720594","LDHi3":"1345522","Lactate1":"1569176","Lactate2":"1145532","Lactate3":"418669"},{"Metabolite":"serine_13C2","Cont1":"589832","Cont2":"21196","Cont3":"17558","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"serine_13C3","Cont1":"8405777","Cont2":"1635573","Cont3":"951110","LDHi1":"36885","LDHi2":"129457","LDHi3":"77446","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"sorbitol / galactitol / L-iditol / manitol","Cont1":"4440817","Cont2":"1214072","Cont3":"1222270","LDHi1":"1337916","LDHi2":"2549557","LDHi3":"2127565","Lactate1":"1552802","Lactate2":"1371577","Lactate3":"1064524"},{"Metabolite":"sorbitol / galactitol / L-iditol / manitol_13C6","Cont1":"1355269","Cont2":"170023","Cont3":"82679","LDHi1":"147060","LDHi2":"338056","LDHi3":"275843","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"succinate","Cont1":"62366045","Cont2":"23427081","Cont3":"17513209","LDHi1":"14055534","LDHi2":"17039255","LDHi3":"16890295","Lactate1":"21309669","Lactate2":"31892542","Lactate3":"16699416"},{"Metabolite":"succinate_13C1","Cont1":"2237027","Cont2":"1000227","Cont3":"563200","LDHi1":"733839","LDHi2":"545361","LDHi3":"768578","Lactate1":"1170564","Lactate2":"1246980","Lactate3":"634023"},{"Metabolite":"succinate_13C2","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"succinate_13C3","Cont1":"13301","Cont2":"21708","Cont3":"0","LDHi1":"16502","LDHi2":"0","LDHi3":"12403","Lactate1":"11108","Lactate2":"0","Lactate3":"0"},{"Metabolite":"succinate_13C4","Cont1":"15259","Cont2":"0","Cont3":"0","LDHi1":"11543","LDHi2":"0","LDHi3":"12373","Lactate1":"0","Lactate2":"0","Lactate3":"21686"},{"Metabolite":"thiamine diphosphate+","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"thiamine phosphate+","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"thiamine+","Cont1":"128282127","Cont2":"95549714","Cont3":"37747277","LDHi1":"33960653","LDHi2":"57261030","LDHi3":"43739931","Lactate1":"57714210","Lactate2":"46408204","Lactate3":"26019896"},{"Metabolite":"UDP-N-acetyl-galactosamine/glucosamine","Cont1":"10596080","Cont2":"1797720","Cont3":"1281762","LDHi1":"1648763","LDHi2":"3439329","LDHi3":"3199766","Lactate1":"2550573","Lactate2":"2618719","Lactate3":"870957"},{"Metabolite":"UDP-N-acetyl-galactosamine/glucosamine_13C13","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"UDP-N-acetyl-galactosamine/glucosamine_13C6","Cont1":"351185","Cont2":"46148","Cont3":"0","LDHi1":"0","LDHi2":"11478","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"UDP-N-acetyl-galactosamine/glucosamine_13C8","Cont1":"18132","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"UMP","Cont1":"1462623","Cont2":"168682","Cont3":"92604","LDHi1":"604213","LDHi2":"1556143","LDHi3":"1479399","Lactate1":"460574","Lactate2":"388883","Lactate3":"38487"},{"Metabolite":"UMP_13C5","Cont1":"0","Cont2":"8873","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"UMP_13C6","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"UMP_13C7","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"UMP_13C8","Cont1":"2695405","Cont2":"595445","Cont3":"327434","LDHi1":"353858","LDHi2":"976365","LDHi3":"890488","Lactate1":"734906","Lactate2":"802270","Lactate3":"180193"},{"Metabolite":"UMP_13C9","Cont1":"298019","Cont2":"40869","Cont3":"11420","LDHi1":"28485","LDHi2":"87506","LDHi3":"71628","Lactate1":"38951","Lactate2":"113501","Lactate3":"11889"},{"Metabolite":"UTP","Cont1":"1405026","Cont2":"368261","Cont3":"529806","LDHi1":"21462","LDHi2":"80131","LDHi3":"40182","Lactate1":"377110","Lactate2":"351697","Lactate3":"76232"},{"Metabolite":"UTP_13C5","Cont1":"130021","Cont2":"14427","Cont3":"37281","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"UTP_13C6","Cont1":"1434562","Cont2":"66371","Cont3":"0","LDHi1":"0","LDHi2":"123626","LDHi3":"199054","Lactate1":"79236","Lactate2":"0","Lactate3":"0"},{"Metabolite":"UTP_13C7","Cont1":"82533","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"UTP_13C8","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"UTP_13C9","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"85395","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"xylitol / arabitol / ribito","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"0","LDHi3":"0","Lactate1":"0","Lactate2":"0","Lactate3":"0"},{"Metabolite":"xylitol / arabitol / ribito_13C5","Cont1":"0","Cont2":"0","Cont3":"0","LDHi1":"0","LDHi2":"10477","LDHi3":"16101","Lactate1":"0","Lactate2":"0","Lactate3":"0"}],

"Metabolites":[{"metabolite_name":"Total Ion Count"},{"metabolite_name":"1,3-diphosphoglycerate"},{"metabolite_name":"1,3-diphosphoglycerate_13C1"},{"metabolite_name":"1,3-diphosphoglycerate_13C2"},{"metabolite_name":"1,3-diphosphoglycerate_13C3"},{"metabolite_name":"2,3-diphosphoglycerate"},{"metabolite_name":"2,3-diphosphoglycerate_13C1"},{"metabolite_name":"2,3-diphosphoglycerate_13C2"},{"metabolite_name":"2,3-diphosphoglycerate_13C3"},{"metabolite_name":"2-HG"},{"metabolite_name":"2-HG_13C1"},{"metabolite_name":"2-HG_13C2"},{"metabolite_name":"2-HG_13C3"},{"metabolite_name":"2-HG_13C4"},{"metabolite_name":"2-HG_13C5"},{"metabolite_name":"2/3-phosphoglycerate"},{"metabolite_name":"2/3-phosphoglycerate_13C1"},{"metabolite_name":"2/3-phosphoglycerate_13C2"},{"metabolite_name":"2/3-phosphoglycerate_13C3"},{"metabolite_name":"3-phospho-serine"},{"metabolite_name":"3-phospho-serine_13C1"},{"metabolite_name":"3-phospho-serine_13C2"},{"metabolite_name":"3-phospho-serine_13C3"},{"metabolite_name":"6-phospho-D-gluconate"},{"metabolite_name":"6-phospho-D-gluconate_13C1"},{"metabolite_name":"6-phospho-D-gluconate_13C2"},{"metabolite_name":"6-phospho-D-gluconate_13C3"},{"metabolite_name":"6-phospho-D-gluconate_13C4"},{"metabolite_name":"6-phospho-D-gluconate_13C5"},{"metabolite_name":"6-phospho-D-gluconate_13C6"},{"metabolite_name":"acetoacetic acid / succinic semialdehyde"},{"metabolite_name":"acetoacetate / succinic semialdehyde_13C1"},{"metabolite_name":"acetoacetate / succinic semialdehyde_13C2"},{"metabolite_name":"acetoacetate / succinic semialdehyde_13C3"},{"metabolite_name":"acetoacetate / succinic semialdehyde_13C4"},{"metabolite_name":"acetyl-CoA +"},{"metabolite_name":"acetyl-CoA_13C1 +"},{"metabolite_name":"acetyl-CoA_13C2 +"},{"metabolite_name":"aconitic acid -"},{"metabolite_name":"aconitic acid_13C1 -"},{"metabolite_name":"aconitic acid_13C2 -"},{"metabolite_name":"adenosine"},{"metabolite_name":"adenosine_13C10"},{"metabolite_name":"adenosine_13C5"},{"metabolite_name":"adenosine_13C6"},{"metabolite_name":"adenosine_13C7"},{"metabolite_name":"adenosine_13C8"},{"metabolite_name":"adenosine_13C9"},{"metabolite_name":"ADP / dGDP"},{"metabolite_name":"ADP / dGDP_13C1"},{"metabolite_name":"ADP / dGDP_13C10"},{"metabolite_name":"ADP / dGDP_13C2"},{"metabolite_name":"ADP / dGDP_13C3"},{"metabolite_name":"ADP / dGDP_13C4"},{"metabolite_name":"ADP / dGDP_13C5"},{"metabolite_name":"ADP / dGDP_13C6"},{"metabolite_name":"ADP / dGDP_13C7"},{"metabolite_name":"ADP / dGDP_13C8"},{"metabolite_name":"ADP / dGDP_13C9"},{"metabolite_name":"AICAR"},{"metabolite_name":"AICAR_13C5"},{"metabolite_name":"AICAR_13C6"},{"metabolite_name":"AICAR_13C7"},{"metabolite_name":"AICAR_13C8"},{"metabolite_name":"AICAR_13C9"},{"metabolite_name":"a-KG"},{"metabolite_name":"a-KG_13C1"},{"metabolite_name":"a-KG_13C2"},{"metabolite_name":"a-KG_13C3"},{"metabolite_name":"a-KG_13C4"},{"metabolite_name":"a-KG_13C5"},{"metabolite_name":"alanine"},{"metabolite_name":"alanine_13C1"},{"metabolite_name":"alanine_13C2"},{"metabolite_name":"alanine_13C3"},{"metabolite_name":"AMP / dGMP"},{"metabolite_name":"AMP / dGMP_13C1"},{"metabolite_name":"AMP / dGMP_13C10"},{"metabolite_name":"AMP / dGMP_13C2"},{"metabolite_name":"AMP / dGMP_13C5"},{"metabolite_name":"AMP / dGMP_13C6"},{"metabolite_name":"AMP / dGMP_13C7"},{"metabolite_name":"AMP / dGMP_13C8"},{"metabolite_name":"AMP / dGMP_13C9"},{"metabolite_name":"aspartate"},{"metabolite_name":"aspartate_13C1"},{"metabolite_name":"aspartate_13C2"},{"metabolite_name":"aspartate_13C3"},{"metabolite_name":"aspartate_13C4"},{"metabolite_name":"ATP / dGTP"},{"metabolite_name":"ATP / dGTP_13C10"},{"metabolite_name":"ATP / dGTP_13C5"},{"metabolite_name":"ATP / dGTP_13C6"},{"metabolite_name":"ATP / dGTP_13C7"},{"metabolite_name":"ATP / dGTP_13C8"},{"metabolite_name":"ATP / dGTP_13C9"},{"metabolite_name":"choline+"},{"metabolite_name":"choline_13C1+"},{"metabolite_name":"choline_13C2+"},{"metabolite_name":"choline_13C3+"},{"metabolite_name":"choline_13C4+"},{"metabolite_name":"choline_13C5+"},{"metabolite_name":"citrate(iso)/citrate"},{"metabolite_name":"citrate(iso)/citrate_13C1"},{"metabolite_name":"citrate(iso)/citrate_13C2"},{"metabolite_name":"citrate(iso)/citrate_13C3"},{"metabolite_name":"citrate(iso)/citrate_13C4"},{"metabolite_name":"citrate(iso)/citrate_13C5"},{"metabolite_name":"citrate(iso)/citrate_13C6"},{"metabolite_name":"CMP"},{"metabolite_name":"CMP_13C5"},{"metabolite_name":"CMP_13C6"},{"metabolite_name":"CMP_13C7"},{"metabolite_name":"CMP_13C8"},{"metabolite_name":"CMP_13C9"},{"metabolite_name":"Crotonyl-CoA"},{"metabolite_name":"CTP"},{"metabolite_name":"CTP_13C5"},{"metabolite_name":"CTP_13C6"},{"metabolite_name":"CTP_13C7"},{"metabolite_name":"CTP_13C8"},{"metabolite_name":"CTP_13C9"},{"metabolite_name":"cystathionine"},{"metabolite_name":"cystathionine_13C1"},{"metabolite_name":"cysteine"},{"metabolite_name":"cysteine_13C1"},{"metabolite_name":"cysteine_13C2"},{"metabolite_name":"cysteine_13C3"},{"metabolite_name":"dATP"},{"metabolite_name":"dATP_13C10"},{"metabolite_name":"dATP_13C5"},{"metabolite_name":"dATP_13C6"},{"metabolite_name":"dATP_13C7"},{"metabolite_name":"dATP_13C8"},{"metabolite_name":"dATP_13C9"},{"metabolite_name":"dCTP"},{"metabolite_name":"dCTP_13C5"},{"metabolite_name":"dCTP_13C6"},{"metabolite_name":"dCTP_13C7"},{"metabolite_name":"dCTP_13C8"},{"metabolite_name":"dCTP_13C9"},{"metabolite_name":"deoxyguanosine"},{"metabolite_name":"deoxyguanosine_13C10"},{"metabolite_name":"deoxyguanosine_13C5"},{"metabolite_name":"deoxyguanosine_13C6"},{"metabolite_name":"deoxyguanosine_13C7"},{"metabolite_name":"deoxyguanosine_13C8"},{"metabolite_name":"deoxyguanosine_13C9"},{"metabolite_name":"D-galactosamine/glucosamine-1/6-phosphate"},{"metabolite_name":"D-galactosamine/glucosamine-1/6-phosphate_13C6"},{"metabolite_name":"GAP / DHAP"},{"metabolite_name":"GAP / DHAP_13C1"},{"metabolite_name":"GAP / DHAP_13C2"},{"metabolite_name":"GAP / DHAP_13C3"},{"metabolite_name":"D-ribose-1/5-phosphate"},{"metabolite_name":"D-ribose-1/5-phosphate_13C1"},{"metabolite_name":"D-ribose-1/5-phosphate_13C2"},{"metabolite_name":"D-ribose-1/5-phosphate_13C3"},{"metabolite_name":"D-ribose-1/5-phosphate_13C4"},{"metabolite_name":"D-ribose-1/5-phosphate_13C5"},{"metabolite_name":"D-sedoheptulose-7-phosphate"},{"metabolite_name":"D-sedoheptulose-7-phosphate_13C1"},{"metabolite_name":"D-sedoheptulose-7-phosphate_13C2"},{"metabolite_name":"D-sedoheptulose-7-phosphate_13C3"},{"metabolite_name":"D-sedoheptulose-7-phosphate_13C4"},{"metabolite_name":"D-sedoheptulose-7-phosphate_13C5"},{"metabolite_name":"D-sedoheptulose-7-phosphate_13C6"},{"metabolite_name":"D-sedoheptulose-7-phosphate_13C7"},{"metabolite_name":"dTTP"},{"metabolite_name":"dTTP_13C10"},{"metabolite_name":"dTTP_13C5"},{"metabolite_name":"dTTP_13C6"},{"metabolite_name":"dTTP_13C7"},{"metabolite_name":"dTTP_13C8"},{"metabolite_name":"dTTP_13C9"},{"metabolite_name":"dUTP"},{"metabolite_name":"dUTP_13C5"},{"metabolite_name":"dUTP_13C6"},{"metabolite_name":"dUTP_13C7"},{"metabolite_name":"dUTP_13C8"},{"metabolite_name":"dUTP_13C9"},{"metabolite_name":"F-1,6/2,6-P"},{"metabolite_name":"F-1,6/2,6-P_13C1"},{"metabolite_name":"F-1,6/2,6-P_13C2"},{"metabolite_name":"F-1,6/2,6-P_13C3"},{"metabolite_name":"F-1,6/2,6-P_13C4"},{"metabolite_name":"F-1,6/2,6-P_13C5"},{"metabolite_name":"F-1,6/2,6-P_13C6"},{"metabolite_name":"fructose / mannose"},{"metabolite_name":"fumarate"},{"metabolite_name":"fumarate_13C1"},{"metabolite_name":"fumarate_13C2"},{"metabolite_name":"fumarate_13C3"},{"metabolite_name":"fumarate_13C4"},{"metabolite_name":"F6P/G1P/G6P"},{"metabolite_name":"F6P/G1P/G6P_13C1"},{"metabolite_name":"F6P/G1P/G6P_13C2"},{"metabolite_name":"F6P/G1P/G6P_13C3"},{"metabolite_name":"F6P/G1P/G6P_13C4"},{"metabolite_name":"F6P/G1P/G6P_13C5"},{"metabolite_name":"F6P/G1P/G6P_13C6"},{"metabolite_name":"galactose / glucose"},{"metabolite_name":"glucose_13C6"},{"metabolite_name":"glutamate"},{"metabolite_name":"glutamate_13C1"},{"metabolite_name":"glutamate_13C2"},{"metabolite_name":"glutamate_13C3"},{"metabolite_name":"glutamate_13C4"},{"metabolite_name":"glutamate_13C5"},{"metabolite_name":"glutamine"},{"metabolite_name":"glutamine_13C1"},{"metabolite_name":"glutamine_13C2"},{"metabolite_name":"glutamine_13C3"},{"metabolite_name":"glutamine_13C4"},{"metabolite_name":"glutamine_13C5"},{"metabolite_name":"glutathione"},{"metabolite_name":"glutathione_13C1"},{"metabolite_name":"glutathione_13C2"},{"metabolite_name":"glutathione_13C3"},{"metabolite_name":"glutathione_13C4"},{"metabolite_name":"glutathione_13C5"},{"metabolite_name":"glutathione disulfide"},{"metabolite_name":"glutathione disulfide_13C1"},{"metabolite_name":"glutathione disulfide_13C2"},{"metabolite_name":"glutathione disulfide_13C3"},{"metabolite_name":"glutathione disulfide_13C4"},{"metabolite_name":"glutathione disulfide_13C5"},{"metabolite_name":"glycerate"},{"metabolite_name":"glycerate_13C1"},{"metabolite_name":"glycerate_13C2"},{"metabolite_name":"glycerate_13C3"},{"metabolite_name":"glycerol-2/3-phosphate"},{"metabolite_name":"glycerol-2/3-phosphate_13C2"},{"metabolite_name":"glycerol-2/3-phosphate_13C3"},{"metabolite_name":"glycine"},{"metabolite_name":"glycine_13C1"},{"metabolite_name":"glycine_13C2"},{"metabolite_name":"GMP"},{"metabolite_name":"GMP_13C10"},{"metabolite_name":"GMP_13C5"},{"metabolite_name":"GMP_13C6"},{"metabolite_name":"GMP_13C7"},{"metabolite_name":"GMP_13C8"},{"metabolite_name":"GMP_13C9"},{"metabolite_name":"GTP"},{"metabolite_name":"GTP_13C10"},{"metabolite_name":"GTP_13C5"},{"metabolite_name":"GTP_13C6"},{"metabolite_name":"GTP_13C7"},{"metabolite_name":"GTP_13C8"},{"metabolite_name":"GTP_13C9"},{"metabolite_name":"guanosine"},{"metabolite_name":"guanosine_13C10"},{"metabolite_name":"guanosine_13C5"},{"metabolite_name":"guanosine_13C6"},{"metabolite_name":"guanosine_13C7"},{"metabolite_name":"guanosine_13C8"},{"metabolite_name":"guanosine_13C9"},{"metabolite_name":"IDP"},{"metabolite_name":"IDP_13C10"},{"metabolite_name":"IDP_13C5"},{"metabolite_name":"IDP_13C6"},{"metabolite_name":"IDP_13C7"},{"metabolite_name":"IDP_13C8"},{"metabolite_name":"IDP_13C9"},{"metabolite_name":"IMP"},{"metabolite_name":"IMP_13C10"},{"metabolite_name":"IMP_13C5"},{"metabolite_name":"IMP_13C6"},{"metabolite_name":"IMP_13C7"},{"metabolite_name":"IMP_13C8"},{"metabolite_name":"IMP_13C9"},{"metabolite_name":"itaconic acid"},{"metabolite_name":"itaconic acid_13C1"},{"metabolite_name":"itaconic acid_13C2"},{"metabolite_name":"lactate"},{"metabolite_name":"lactate_13C1"},{"metabolite_name":"lactate_13C2"},{"metabolite_name":"lactate_13C3"},{"metabolite_name":"leucine / leucine(iso)"},{"metabolite_name":"leucine / leucine(iso)_13C1"},{"metabolite_name":"leucine / leucine(iso)_13C2"},{"metabolite_name":"leucine / leucine(iso)_13C3"},{"metabolite_name":"leucine / leucine(iso)_13C6"},{"metabolite_name":"malate"},{"metabolite_name":"malate_13C1"},{"metabolite_name":"malate_13C2"},{"metabolite_name":"malate_13C3"},{"metabolite_name":"malate_13C4"},{"metabolite_name":"mevalonate"},{"metabolite_name":"mevalonate_13C1"},{"metabolite_name":"mevalonate_13C2"},{"metabolite_name":"mevalonate_13C3"},{"metabolite_name":"mevalonate_13C4"},{"metabolite_name":"mevalonate_13C5"},{"metabolite_name":"mevalonate_13C6"},{"metabolite_name":"N-acetyl-glucosamine-1/6-phosphate"},{"metabolite_name":"N-acetyl-glucosamine-1/6-phosphate_13C6"},{"metabolite_name":"N-acetyl-glucosamine-1/6-phosphate_13C8"},{"metabolite_name":"NAD+"},{"metabolite_name":"NADH"},{"metabolite_name":"NADP+"},{"metabolite_name":"NADPH"},{"metabolite_name":"N-carbamoyl-L-aspartate"},{"metabolite_name":"N-carbamoyl-L-aspartate_13C1"},{"metabolite_name":"N-carbamoyl-L-aspartate_13C2"},{"metabolite_name":"N-carbamoyl-L-aspartate_13C3"},{"metabolite_name":"N-carbamoyl-L-aspartate_13C4"},{"metabolite_name":"N-carbamoyl-L-aspartate_13C5"},{"metabolite_name":"oxaloacetate"},{"metabolite_name":"oxaloacetate_13C1"},{"metabolite_name":"oxaloacetate_13C2"},{"metabolite_name":"oxaloacetate_13C3"},{"metabolite_name":"oxaloacetate_13C4"},{"metabolite_name":"phosphoenolpyruvate"},{"metabolite_name":"phosphoenolpyruvate_13C1"},{"metabolite_name":"phosphoenolpyruvate_13C2"},{"metabolite_name":"phosphoenolpyruvate_13C3"},{"metabolite_name":"PRPP"},{"metabolite_name":"PRPP_13C1"},{"metabolite_name":"PRPP_13C2"},{"metabolite_name":"PRPP_13C3"},{"metabolite_name":"PRPP_13C4"},{"metabolite_name":"PRPP_13C5"},{"metabolite_name":"pyruvate"},{"metabolite_name":"pyruvate_13C1"},{"metabolite_name":"pyruvate_13C2"},{"metabolite_name":"pyruvate_13C3"},{"metabolite_name":"S-adenosyl-L-homoCysteine"},{"metabolite_name":"S-adenosyl-L-homoCysteine_13C1"},{"metabolite_name":"S-adenosyl-L-methionine"},{"metabolite_name":"S-adenosyl-L-methionine_13C1"},{"metabolite_name":"S-adenosyl-L-methionine_13C2"},{"metabolite_name":"S-adenosyl-L-methionine_13C3"},{"metabolite_name":"S-adenosyl-L-methionine_13C4"},{"metabolite_name":"S-adenosyl-L-methionine_13C5"},{"metabolite_name":"S-adenosyl-L-methionine_13C6"},{"metabolite_name":"S-adenosyl-L-methionine_13C7"},{"metabolite_name":"S-adenosyl-L-methionine_13C8"},{"metabolite_name":"S-adenosyl-L-methionine_13C9"},{"metabolite_name":"serine"},{"metabolite_name":"serine_13C1"},{"metabolite_name":"serine_13C2"},{"metabolite_name":"serine_13C3"},{"metabolite_name":"sorbitol / galactitol / L-iditol / manitol"},{"metabolite_name":"sorbitol / galactitol / L-iditol / manitol_13C6"},{"metabolite_name":"succinate"},{"metabolite_name":"succinate_13C1"},{"metabolite_name":"succinate_13C2"},{"metabolite_name":"succinate_13C3"},{"metabolite_name":"succinate_13C4"},{"metabolite_name":"thiamine diphosphate+"},{"metabolite_name":"thiamine phosphate+"},{"metabolite_name":"thiamine+"},{"metabolite_name":"UDP-N-acetyl-galactosamine/glucosamine"},{"metabolite_name":"UDP-N-acetyl-galactosamine/glucosamine_13C13"},{"metabolite_name":"UDP-N-acetyl-galactosamine/glucosamine_13C6"},{"metabolite_name":"UDP-N-acetyl-galactosamine/glucosamine_13C8"},{"metabolite_name":"UMP"},{"metabolite_name":"UMP_13C5"},{"metabolite_name":"UMP_13C6"},{"metabolite_name":"UMP_13C7"},{"metabolite_name":"UMP_13C8"},{"metabolite_name":"UMP_13C9"},{"metabolite_name":"UTP"},{"metabolite_name":"UTP_13C5"},{"metabolite_name":"UTP_13C6"},{"metabolite_name":"UTP_13C7"},{"metabolite_name":"UTP_13C8"},{"metabolite_name":"UTP_13C9"},{"metabolite_name":"xylitol / arabitol / ribito"},{"metabolite_name":"xylitol / arabitol / ribito_13C5"}]
}

}