{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002525","ANALYSIS_ID":"AN004159","VERSION":"1","CREATED_ON":"March 27, 2023, 8:25 am"},

"PROJECT":{"PROJECT_TITLE":"In situ microwave fixation provides an instantaneous snapshot of the brain metabolome","PROJECT_SUMMARY":"The brain metabolome directly connects to brain physiology and neuronal function. Brain glucose metabolism is highly heterogeneous among brain regions and continues postmortem. Therefore, challenges remain to capture an accurate snapshot of the physiological brain metabolome in healthy and diseased rodent models. To overcome this barrier, we employed high-power focused microwave for the simultaneous euthanasia and fixation of mouse brain tissue to preserve metabolite pools prior to surgical removal and dissection of brain regions. We demonstrate exhaustion of glycogen and glucose and an increase in lactate production during conventional rapid brain resection prior to preservation by liquid nitrogen that is not observed with microwave fixation. Next, microwave fixation was employed to define the impact of brain glucose metabolism in the mouse model of streptozotocin-induced type 1 diabetes. Using both total pool and isotope tracing analyses, we identified global glucose hypometabolism in multiple regions of the mouse brain, evidenced by reduced 13C enrichment into glycogen, glycolysis, and the TCA cycle. Reduced glucose metabolism correlated with a marked decrease in GLUT2 expression and several metabolic enzymes in unique brain regions. In conclusion, our study supports the incorporation of microwave fixation to study terminal brain metabolism in rodent models.","INSTITUTE":"University of Florida","DEPARTMENT":"Biochemistry and Molecular Biology","LABORATORY":"Sun lab","LAST_NAME":"sun","FIRST_NAME":"ramon","ADDRESS":"1200 Newell Drive, ARB","EMAIL":"ramonsun@ufl.edu","PHONE":"3522948407"},

"STUDY":{"STUDY_TITLE":"In situ microwave fixation provides an instantaneous snapshot of the brain metabolome - Part 2","STUDY_SUMMARY":"We demonstrate exhaustion of glycogen and glucose and an increase in lactate production during conventional rapid brain resection prior to preservation by liquid nitrogen that is not observed with microwave fixation. Next, microwave fixation was employed to define the impact of brain glucose metabolism in the mouse model of streptozotocin-induced type 1 diabetes. Using both total pool and isotope tracing analyses, we identified global glucose hypometabolism in multiple regions of the mouse brain, evidenced by reduced 13C enrichment into glycogen, glycolysis, and the TCA cycle. Reduced glucose metabolism correlated with a marked decrease in GLUT2 expression and several metabolic enzymes in unique brain regions. In conclusion, our study supports the incorporation of microwave fixation to study terminal brain metabolism in rodent models.","INSTITUTE":"University of Florida","LAST_NAME":"Sun","FIRST_NAME":"Ramon","ADDRESS":"1200 Newell Drive, ARB","EMAIL":"ramonsun@ufl.edu","PHONE":"3522948407"},

"SUBJECT":{"SUBJECT_TYPE":"Mammal","SUBJECT_SPECIES":"Mus musculus","TAXONOMY_ID":"10090"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"CTX Vehicle 1",
"Factors":{"Treatment":"vehicle","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle CTX_1_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX Vehicle 2",
"Factors":{"Treatment":"vehicle","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle CTX_2_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX Vehicle 3",
"Factors":{"Treatment":"vehicle","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle CTX_3_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX Vehicle 4",
"Factors":{"Treatment":"vehicle","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle CTX_4_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX Vehicle 5",
"Factors":{"Treatment":"vehicle","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle CTX_5_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX Vehicle 6",
"Factors":{"Treatment":"vehicle","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle CTX_6_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX Vehicle 7",
"Factors":{"Treatment":"vehicle","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle CTX_7_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC Vehicle 1",
"Factors":{"Treatment":"vehicle","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle DVC_1_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC Vehicle 2",
"Factors":{"Treatment":"vehicle","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle DVC_2_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC Vehicle 3",
"Factors":{"Treatment":"vehicle","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle DVC_3_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC Vehicle 4",
"Factors":{"Treatment":"vehicle","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle DVC_4_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC Vehicle 5",
"Factors":{"Treatment":"vehicle","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle DVC_5_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC Vehicle 6",
"Factors":{"Treatment":"vehicle","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle DVC_6_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC Vehicle 7",
"Factors":{"Treatment":"vehicle","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle DVC_7_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC Vehicle 8",
"Factors":{"Treatment":"vehicle","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle DVC_8_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp Vehicle 1",
"Factors":{"Treatment":"vehicle","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle Hipp_1_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp Vehicle 2",
"Factors":{"Treatment":"vehicle","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle Hipp_2_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp Vehicle 3",
"Factors":{"Treatment":"vehicle","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle Hipp_3_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp Vehicle 4",
"Factors":{"Treatment":"vehicle","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle Hipp_4_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp Vehicle 5",
"Factors":{"Treatment":"vehicle","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle Hipp_5_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp Vehicle 6",
"Factors":{"Treatment":"vehicle","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle Hipp_6_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp Vehicle 7",
"Factors":{"Treatment":"vehicle","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle Hipp_7_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp Vehicle 8",
"Factors":{"Treatment":"vehicle","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state vehicle Hipp_8_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX T1DM 1",
"Factors":{"Treatment":"STZ","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM CTX_1_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX T1DM 2",
"Factors":{"Treatment":"STZ","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM CTX_2_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX T1DM 3",
"Factors":{"Treatment":"STZ","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM CTX_3_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX T1DM 4",
"Factors":{"Treatment":"STZ","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM CTX_4_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX T1DM 5",
"Factors":{"Treatment":"STZ","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM CTX_5_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX T1DM 6",
"Factors":{"Treatment":"STZ","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM CTX_6_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"CTX T1DM 7",
"Factors":{"Treatment":"STZ","Tissue Region":"cortex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM CTX_7_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC T1DM 1",
"Factors":{"Treatment":"STZ","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM DVC_1_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC T1DM 2",
"Factors":{"Treatment":"STZ","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM DVC_2_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC T1DM 3",
"Factors":{"Treatment":"STZ","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM DVC_3_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC T1DM 4",
"Factors":{"Treatment":"STZ","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM DVC_4_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC T1DM 5",
"Factors":{"Treatment":"STZ","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM DVC_5_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC T1DM 6",
"Factors":{"Treatment":"STZ","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM DVC_6_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC T1DM 7",
"Factors":{"Treatment":"STZ","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM DVC_7_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"DVC T1DM 8",
"Factors":{"Treatment":"STZ","Tissue Region":"dorsal vagal complex"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM DVC_8_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp T1DM 1",
"Factors":{"Treatment":"STZ","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM Hipp_1_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp T1DM 2",
"Factors":{"Treatment":"STZ","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM Hipp_2_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp T1DM 3",
"Factors":{"Treatment":"STZ","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM Hipp_3_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp T1DM 4",
"Factors":{"Treatment":"STZ","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM Hipp_4_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp T1DM 5",
"Factors":{"Treatment":"STZ","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM Hipp_5_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp T1DM 6",
"Factors":{"Treatment":"STZ","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM Hipp_6_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp T1DM 7",
"Factors":{"Treatment":"STZ","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM Hipp_7_polar.CDF"}
},
{
"Subject ID":"-",
"Sample ID":"Hipp T1DM 8",
"Factors":{"Treatment":"STZ","Tissue Region":"Hippocampus"},
"Additional sample data":{"Preservation method":"focused microwave","RAW_FILE_NAME":"steady state T1DM Hipp_8_polar.CDF"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Mice were euthanized by microwave fixation system at 5kW for 0.6 seconds (MMW-05, Muromachi Kikai Company, Japan). Brain regions (HIPP, CTX, DVC), as well as muscle and liver, were dissected postmortem.","SAMPLE_TYPE":"Brain"},

"TREATMENT":{"TREATMENT_SUMMARY":"We designed a two-arm study, where euthanasia occurs through either 1) direct decapitation or 2) focused microwave (Fig. 1). In both arms, we performed rapid dissection of the brain followed by cryopreservation in liquid nitrogen. The major difference between the two arms is the tissue fixation or enzyme inactivation step occurs either during cryopreservation for decapitation (CP, ~90 seconds) or focused microwave (FM, ~0.6 second)."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Brains were removed immediately post-mortem, and washed once with PBS, twice with diH2O, blotted dry, and snap frozen in liquid nitrogen. Other set of brains were snap frozen after microwave fixation as described above. The frozen tissues were pulverized to 10 μm particles in liquid N2 using a Freezer/Mill Cryogenic Grinder (SPEX SamplePrep). Brain regions were extracted with 1ml of 50% methanol in the grinder, while for muscle and liver twenty milligrams of each pulverized tissue were extracted in 1ml of 50% methanol and separated into polar (aqueous layer), and protein/DNA/RNA/glycogen pellet. The polar fraction was dried at 10-3 mBar using a SpeedVac (Thermo) followed by derivatization."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"Agilent 7890A","COLUMN_NAME":"Agilent HP5-MS (30m x 0.25mm, 0.25 um)","SOLVENT_A":"na","SOLVENT_B":"na","FLOW_GRADIENT":"na","FLOW_RATE":"0.69 ml/min","COLUMN_TEMPERATURE":"60-325"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 5975C","INSTRUMENT_TYPE":"Single quadrupole","MS_TYPE":"EI","ION_MODE":"POSITIVE","MS_COMMENTS":"GCMS protocols were similar to those described previously with a modified temperature gradient was used for GC: Initial temperature was 130degC, held for 4 minutes, rising at 6degC/minutes to 243degC, rising at 60degC/minutes to 280degC, held for 2 minutes. The electron ionization (EI) energy was set to 70 eV. Scan (m/z:50-800) and full scan mode were used for metabolomics analysis. Mass spectra were translated to relative metabolite abundance using the Automated Mass Spectral Deconvolution and Identification System (AMDIS) software matched to the FiehnLib metabolomics library (available through Agilent) for retention time and fragmentation pattern matching with a confidence score of > 80 (Fiehn, 2016; Fiehn et al., 2000; Kind et al., 2009). Data was further analyzed using the Data Extraction for Stable Isotope-labelled Metabolites (DEXSI) software package. Untargeted metabolomics data was normalized to total ion chromatogram. For glucose tracer raw data was exported and correction for natural abundance was done by IsoCorrectoR. Fractional enrichment of each metabolite was calculated as the relative abundance of each isotopologue relative to the sum of all other isotopologues. Mean enrichment was calculated as sum of fractional enrichment of labeled isotopologues (M1, M2, M3…). For principal component analysis, pathway impact analysis the online tool Metaboanlyst was used (https://www.metaboanalyst.ca/). Data was auto scaled and log transformed."},

"MS_METABOLITE_DATA":{
"Units":"Relative abundance",

"Data":[{"Metabolite":"pyruvic acid","CTX Vehicle 1":"0.000355795","CTX Vehicle 2":"0.000540831","CTX Vehicle 3":"0.000474144","CTX Vehicle 4":"0.000345407","CTX Vehicle 5":"0.000232742","CTX Vehicle 6":"0.000361389","CTX Vehicle 7":"0.000557111","CTX T1DM 1":"0.000317599","CTX T1DM 2":"0.00038259","CTX T1DM 3":"0.000371612","CTX T1DM 4":"0.000241148","CTX T1DM 5":"0.000450591","CTX T1DM 6":"0.00040899","CTX T1DM 7":"0.000418736","Hipp Vehicle 1":"0.000762593","Hipp Vehicle 2":"0.000476518","Hipp Vehicle 3":"0.000565927","Hipp Vehicle 4":"0.001207459","Hipp Vehicle 5":"0.000228738","Hipp Vehicle 6":"0.000683312","Hipp Vehicle 7":"0.000660513","Hipp Vehicle 8":"0.000761692","Hipp T1DM 1":"0.000341017","Hipp T1DM 2":"0.000190849","Hipp T1DM 3":"0.000321232","Hipp T1DM 4":"0.000459764","Hipp T1DM 5":"0.000466321","Hipp T1DM 6":"0.00024309","Hipp T1DM 7":"0.00023933","Hipp T1DM 8":"0.000727506","DVC Vehicle 1":"0.000730798","DVC Vehicle 2":"0.000718247","DVC Vehicle 3":"0.001046166","DVC Vehicle 4":"0.000724193","DVC Vehicle 5":"0.000764855","DVC Vehicle 6":"0.00067652","DVC Vehicle 7":"0.001254425","DVC Vehicle 8":"0.000901192","DVC T1DM 1":"0.000606488","DVC T1DM 2":"0.000316655","DVC T1DM 3":"0.000738827","DVC T1DM 4":"0.0012704","DVC T1DM 5":"0.00015067","DVC T1DM 6":"0.000311917","DVC T1DM 7":"0.000925412","DVC T1DM 8":"0.000416633"},{"Metabolite":"lactic acid","CTX Vehicle 1":"0.005792314","CTX Vehicle 2":"0.004937368","CTX Vehicle 3":"0.00692446","CTX Vehicle 4":"0.008740828","CTX Vehicle 5":"0.008069367","CTX Vehicle 6":"0.008177743","CTX Vehicle 7":"0.00557863","CTX T1DM 1":"0.005957876","CTX T1DM 2":"0.006149094","CTX T1DM 3":"0.005160857","CTX T1DM 4":"0.005834294","CTX T1DM 5":"0.013176972","CTX T1DM 6":"0.00868006","CTX T1DM 7":"0.006542087","Hipp Vehicle 1":"0.006835776","Hipp Vehicle 2":"0.006179573","Hipp Vehicle 3":"0.007931519","Hipp Vehicle 4":"0.018198215","Hipp Vehicle 5":"0.0070787","Hipp Vehicle 6":"0.008775972","Hipp Vehicle 7":"0.006611803","Hipp Vehicle 8":"0.006951969","Hipp T1DM 1":"0.005309245","Hipp T1DM 2":"0.003828833","Hipp T1DM 3":"0.004937133","Hipp T1DM 4":"0.007147347","Hipp T1DM 5":"0.012161132","Hipp T1DM 6":"0.00896693","Hipp T1DM 7":"0.005922029","Hipp T1DM 8":"0.005769587","DVC Vehicle 1":"0.009361982","DVC Vehicle 2":"0.007876798","DVC Vehicle 3":"0.010445596","DVC Vehicle 4":"0.010467258","DVC Vehicle 5":"0.01159612","DVC Vehicle 6":"0.015482592","DVC Vehicle 7":"0.018945975","DVC Vehicle 8":"0.011301381","DVC T1DM 1":"0.00926506","DVC T1DM 2":"0.006516463","DVC T1DM 3":"0.009869921","DVC T1DM 4":"0.021249574","DVC T1DM 5":"0.003833419","DVC T1DM 6":"0.007719907","DVC T1DM 7":"0.00840368","DVC T1DM 8":"0.008991827"},{"Metabolite":"alanine","CTX Vehicle 1":"0.003975842","CTX Vehicle 2":"0.00349164","CTX Vehicle 3":"0.005132346","CTX Vehicle 4":"0.004344651","CTX Vehicle 5":"0.005032491","CTX Vehicle 6":"0.004107313","CTX Vehicle 7":"0.004000918","CTX T1DM 1":"0.004095863","CTX T1DM 2":"0.004873379","CTX T1DM 3":"0.006037151","CTX T1DM 4":"0.003748143","CTX T1DM 5":"0.003639457","CTX T1DM 6":"0.007958073","CTX T1DM 7":"0.004292076","Hipp Vehicle 1":"0.00581381","Hipp Vehicle 2":"0.005675964","Hipp Vehicle 3":"0.006361409","Hipp Vehicle 4":"0.007429129","Hipp Vehicle 5":"0.005607525","Hipp Vehicle 6":"0.004696655","Hipp Vehicle 7":"0.004572874","Hipp Vehicle 8":"0.005455152","Hipp T1DM 1":"0.005463694","Hipp T1DM 2":"0.004667044","Hipp T1DM 3":"0.006013382","Hipp T1DM 4":"0.008435576","Hipp T1DM 5":"0.005185219","Hipp T1DM 6":"0.007757862","Hipp T1DM 7":"0.006087425","Hipp T1DM 8":"0.004486601","DVC Vehicle 1":"0.003159242","DVC Vehicle 2":"0.003515403","DVC Vehicle 3":"0.003874137","DVC Vehicle 4":"0.004050885","DVC Vehicle 5":"0.003655444","DVC Vehicle 6":"0.005692398","DVC Vehicle 7":"0.004387892","DVC Vehicle 8":"0.004041607","DVC T1DM 1":"0.00687366","DVC T1DM 2":"0.005272582","DVC T1DM 3":"0.005100577","DVC T1DM 4":"0.00398486","DVC T1DM 5":"0.003792052","DVC T1DM 6":"0.005890713","DVC T1DM 7":"0.003494082","DVC T1DM 8":"0.006236502"},{"Metabolite":"valine","CTX Vehicle 1":"0.001669634","CTX Vehicle 2":"0.00191467","CTX Vehicle 3":"0.001877598","CTX Vehicle 4":"0.001543894","CTX Vehicle 5":"0.002052058","CTX Vehicle 6":"0.002206017","CTX Vehicle 7":"0.001930958","CTX T1DM 1":"0.00533123","CTX T1DM 2":"0.005095552","CTX T1DM 3":"0.003943719","CTX T1DM 4":"0.005336458","CTX T1DM 5":"0.005191298","CTX T1DM 6":"0.004601264","CTX T1DM 7":"0.005001348","Hipp Vehicle 1":"0.001978952","Hipp Vehicle 2":"0.001674617","Hipp Vehicle 3":"0.002304023","Hipp Vehicle 4":"0.002104279","Hipp Vehicle 5":"0.001813365","Hipp Vehicle 6":"0.002034572","Hipp Vehicle 7":"0.002357094","Hipp Vehicle 8":"0.002258754","Hipp T1DM 1":"0.003505776","Hipp T1DM 2":"0.003268407","Hipp T1DM 3":"0.003289907","Hipp T1DM 4":"0.004282743","Hipp T1DM 5":"0.003757505","Hipp T1DM 6":"0.004571403","Hipp T1DM 7":"0.003645747","Hipp T1DM 8":"0.00343734","DVC Vehicle 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"Metabolites":[{"Metabolite":"pyruvic acid","PubChem ID":"1060","KEGG":"C00022"},{"Metabolite":"lactic acid","PubChem ID":"61503","KEGG":"C00186"},{"Metabolite":"alanine","PubChem ID":"5950","KEGG":"C00041"},{"Metabolite":"valine","PubChem ID":"6287","KEGG":"C00183"},{"Metabolite":"serine","PubChem ID":"5951","KEGG":"C00716"},{"Metabolite":"leucine","PubChem ID":"6106","KEGG":"C00123"},{"Metabolite":"phosphoric acid","PubChem ID":"57424078","KEGG":"C00009"},{"Metabolite":"isoleucine","PubChem ID":"6306","KEGG":"C00407"},{"Metabolite":"proline","PubChem ID":"145742","KEGG":"C00148"},{"Metabolite":"glycine","PubChem ID":"750","KEGG":"C00037"},{"Metabolite":"succinate","PubChem ID":"1110","KEGG":"C00042"},{"Metabolite":"fumaric acid","PubChem ID":"444972","KEGG":"C00122"},{"Metabolite":"threonine","PubChem ID":"6288","KEGG":"C00188"},{"Metabolite":"beta-alanine","PubChem ID":"239","KEGG":"C00099"},{"Metabolite":"nicotinamide","PubChem ID":"936","KEGG":"C00153"},{"Metabolite":"malic acid","PubChem ID":"525","KEGG":"C03668"},{"Metabolite":"aspartic acid","PubChem ID":"5960","KEGG":"C00049"},{"Metabolite":"GABA","PubChem ID":"223130","KEGG":"C00334"},{"Metabolite":"Phenylalanine","PubChem ID":"6140","KEGG":"C00079"},{"Metabolite":"creatinine","PubChem ID":"588","KEGG":"C00791"},{"Metabolite":"2-oxoglutaric acid","PubChem ID":"51","KEGG":"C00026"},{"Metabolite":"phosphoenolpyruvate","PubChem ID":"1005","KEGG":"C00074"},{"Metabolite":"glutamic acid","PubChem ID":"33032","KEGG":"C00025"},{"Metabolite":"N-acetyl-L-aspartic acid","PubChem ID":"65065","KEGG":"C01042"},{"Metabolite":"pyrophosphate","PubChem ID":"644102","KEGG":"C00013"},{"Metabolite":"taurine","PubChem ID":"1123","KEGG":"C00245"},{"Metabolite":"dihydroxyacetone phosphate","PubChem ID":"668","KEGG":"C00111"},{"Metabolite":"glycerol 1-phosphate","PubChem ID":"439162","KEGG":"C00093"},{"Metabolite":"glutamine","PubChem ID":"5961","KEGG":"C00064"},{"Metabolite":"3-phosphoglyceric acid","PubChem ID":"724","KEGG":"C00597"},{"Metabolite":"citric acid","PubChem ID":"311","KEGG":"C00158"},{"Metabolite":"dehydroascorbic acid","PubChem ID":"7786","KEGG":"C05422"},{"Metabolite":"adenine","PubChem ID":"190","KEGG":"C00147"},{"Metabolite":"tyrosine","PubChem ID":"6057","KEGG":"C00082"},{"Metabolite":"fructose","PubChem ID":"439709","KEGG":"C02336"},{"Metabolite":"glucose","PubChem ID":"5793","KEGG":"C00221"},{"Metabolite":"lysine","PubChem ID":"5962","KEGG":"C00047"},{"Metabolite":"sorbitol","PubChem ID":"5780","KEGG":"C00794"},{"Metabolite":"pantothenic acid","PubChem ID":"6613","KEGG":"C00864"},{"Metabolite":"palmitic acid","PubChem ID":"985","KEGG":"C00249"},{"Metabolite":"myo-inositol","PubChem ID":"NA","KEGG":"C00137"},{"Metabolite":"ribose-5-phosphate","PubChem ID":"439167","KEGG":"C00117"},{"Metabolite":"spermidine","PubChem ID":"1102","KEGG":"C00315"},{"Metabolite":"stearic acid","PubChem ID":"5281","KEGG":"C01530"},{"Metabolite":"fructose 6-phosphate","PubChem ID":"69507","KEGG":"C00085"},{"Metabolite":"glucose-6-phosphate","PubChem ID":"5958","KEGG":"C00092"},{"Metabolite":"adenosine monophosphate","PubChem ID":"6083","KEGG":"C00020"},{"Metabolite":"cholesterol","PubChem ID":"5997","KEGG":"C00187"},{"Metabolite":"D-galactose","PubChem ID":"439357","KEGG":"C00984"},{"Metabolite":"D-mannose","PubChem ID":"18950","KEGG":"C00936"},{"Metabolite":"Galactosamine","PubChem ID":"NA","KEGG":"C02262"},{"Metabolite":"Glucosamine","PubChem ID":"439213","KEGG":"C00329"},{"Metabolite":"Glycogen","PubChem ID":"439177","KEGG":"C00182"}]
}

}