{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002541","ANALYSIS_ID":"AN004186","VERSION":"1","CREATED_ON":"April 6, 2023, 11:09 am"},

"PROJECT":{"PROJECT_TITLE":"The metabolomics analysis of Methionine restriction","PROJECT_TYPE":"targeted metabolomics data","PROJECT_SUMMARY":"Methionine restriction (MR) provides metabolic benefits in many organisms. However, mechanisms underlying the MR-induced effect remain incompletely understood. Here, we show in the budding yeast S. cerevisiae that MR relays a signal of S-adenosylmethionine (SAM) deprivation to adapt bioenergetic mitochondria to nitrogenic anabolism.In particular, decreases in cellular SAM constrain lipoate metabolism and protein lipoylation required for the operation of the tricarboxylic acid (TCA) cycle in the mitochondria, leading to incomplete glucose oxidation with an exit of acetyl-CoA and -ketoglutarate from the TCA cycle to the syntheses of amino acids, such as arginine and leucine. This mitochondrial SAM-induced response, namely mitoSIR, promotes cell fitness through the coordination of mitochondrial fuel metabolism with the nitrogenic synthesis of amino acids.","INSTITUTE":"Life Sciences Institute, ZheJiang University","LAST_NAME":"Cunqi","FIRST_NAME":"Ye","ADDRESS":"866 Yuhangtang Rd, Hangzhou 310058, P.R. China","EMAIL":"yecunqi@zju.edu.cn","PHONE":"15267181160"},

"STUDY":{"STUDY_TITLE":"Methionine restriction constrains lipoylation and activates mitochondria for nitrogenic synthesis of amino acids (Part 1)","STUDY_SUMMARY":"Methionine restriction (MR) provides metabolic benefits in many organisms. However, mechanisms underlying the MR-induced effect remain incompletely understood. Here, we show in the budding yeast S. cerevisiae that MR relays a signal of S-adenosylmethionine (SAM) deprivation to adapt bioenergetic mitochondria to nitrogenic anabolism. In particular, decreases in cellular SAM constrain lipoate metabolism and protein lipoylation required for the operation of the tricarboxylic acid (TCA) cycle in the mitochondria, leading to incomplete glucose oxidation with an exit of acetyl-CoA and -ketoglutarate from the TCA cycle to the syntheses of amino acids, such as arginine and leucine. This mitochondrial SAM-induced response, namely mitoSIR, promotes cell fitness through the coordination of mitochondrial fuel metabolism with the nitrogenic synthesis of amino acids.","INSTITUTE":"Life Sciences Institute, ZheJiang University","LAST_NAME":"Cunqi","FIRST_NAME":"Ye","ADDRESS":"866 Yuhangtang Rd, Hangzhou 310058, P.R. China","EMAIL":"yecunqi@zju.edu.cn","PHONE":"15267181160"},

"SUBJECT":{"SUBJECT_TYPE":"Yeast","SUBJECT_SPECIES":"Saccharomyces cerevisiae","TAXONOMY_ID":"4932","GENOTYPE_STRAIN":"CEN.P.K"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"met6KO_0h_1",
"Factors":{"Sample Type":"0h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_0h_1.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_0h_2",
"Factors":{"Sample Type":"0h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_0h_2.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_0h_3",
"Factors":{"Sample Type":"0h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_0h_3.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_2h_1",
"Factors":{"Sample Type":"2h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_2h_1.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_2h_2",
"Factors":{"Sample Type":"2h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_2h_2.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_2h_3",
"Factors":{"Sample Type":"2h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_2h_3.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_4h_1",
"Factors":{"Sample Type":"4h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_4h_1.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_4h_2",
"Factors":{"Sample Type":"4h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_4h_2.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_4h_3",
"Factors":{"Sample Type":"4h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_4h_3.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_6h_1",
"Factors":{"Sample Type":"6h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_6h_1.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_6h_2",
"Factors":{"Sample Type":"6h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_6h_2.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_6h_3",
"Factors":{"Sample Type":"6h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_6h_3.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_15h_1",
"Factors":{"Sample Type":"15h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_15h_1.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_15h_2",
"Factors":{"Sample Type":"15h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_15h_2.wiff"}
},
{
"Subject ID":"-",
"Sample ID":"met6KO_15h_3",
"Factors":{"Sample Type":"15h"},
"Additional sample data":{"RAW_FILE_NAME":"met6KO_15h_3.wiff"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Care was taken to quench cells quickly in -40℃ and maintain metabolites in acid to minimize oxidation","SAMPLE_TYPE":"Yeast cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"Mutant MET6KO cells were cultured in SD medium with the supplements of Met and growed to log phase, then cells were washed with normal SD medium and re-cultured in SD medium"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Briefly, equal OD units of cells were rapidly quenched to stop metabolism by addition into 4 volumes of quenching buffer containing 60% methanol and 10 mM Tricine, pH 7.4 that was pre-cooled to -40°C. 5 min after holding at -40°C, cells were spun at 5,000 g for 3 min at 0°C, washed with the same buffer, and then resuspended in 1 mL extraction buffer containing 75% ethanol and 0.5 mM Tricine, pH 7.4. Intracellular metabolites were extracted by incubating at 75°C for 3 min, followed by chilling on ice for 5 min. Samples were spun at 20,000 g for 1 min to pellet cell debris, and 0.9 mL of the supernatant was transferred to a new tube. After a second spin at 20,000 g for 10 min, 0.8 mL of the supernatant was transferred to a new tube. Metabolites in the extraction buffer were dried using a vacuum concentrator system (Labconco) and stored at -80°C until analysis. Dried metabolite extracts were resuspended in 60% acetonitrile for injection."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"Low pH polar","CHROMATOGRAPHY_TYPE":"HILIC","INSTRUMENT_NAME":"Shimadzu 20AD","COLUMN_NAME":"Merck SeQuant ZIC-pHILIC (150 x 2.1mm,5um)","SOLVENT_A":"20 mM ammonium carbonate and 0.1% (v/v) ammonium hydroxide","SOLVENT_B":"acetonitrile","FLOW_GRADIENT":"0.01 min 80% B, 20 min 20% B, 20.5 min 80% B, 34 min 80% B.","FLOW_RATE":"0.15ml/min","COLUMN_TEMPERATURE":"45"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"ABI Sciex 6500+","INSTRUMENT_TYPE":"QTRAP","MS_TYPE":"ESI","ION_MODE":"POSITIVE","MS_COMMENTS":"SCIEX OS"},

"MS_METABOLITE_DATA":{
"Units":"Peak intensity",

"Data":[{"Metabolite":"Urea","met6KO_0h_1":"940986.3436","met6KO_0h_2":"769611.7903","met6KO_0h_3":"842261.4398","met6KO_2h_1":"718109.7533","met6KO_2h_2":"899621.9125","met6KO_2h_3":"863348.7546","met6KO_4h_1":"880729.1284","met6KO_4h_2":"887198.6118","met6KO_4h_3":"630411.5278","met6KO_6h_1":"635595.5685","met6KO_6h_2":"681972.15","met6KO_6h_3":"793087.2237","met6KO_15h_1":"1004964.974","met6KO_15h_2":"859400.0124","met6KO_15h_3":"808811.8004"},{"Metabolite":"Ethanolamine","met6KO_0h_1":"41419.87897","met6KO_0h_2":"93641.94105","met6KO_0h_3":"57108.74191","met6KO_2h_1":"41232.54481","met6KO_2h_2":"112299.3596","met6KO_2h_3":"111903.1814","met6KO_4h_1":"132868.5871","met6KO_4h_2":"260648.061","met6KO_4h_3":"703840.8838","met6KO_6h_1":"421327.1959","met6KO_6h_2":"423218.222","met6KO_6h_3":"82956.96875","met6KO_15h_1":"1808354.639","met6KO_15h_2":"1560356.386","met6KO_15h_3":"1214869.208"},{"Metabolite":"Imidazole","met6KO_0h_1":"83854.58409","met6KO_0h_2":"70615.88886","met6KO_0h_3":"87802.644","met6KO_2h_1":"76472.90476","met6KO_2h_2":"41146.91481","met6KO_2h_3":"23853.88061","met6KO_4h_1":"126038.0686","met6KO_4h_2":"112574.2662","met6KO_4h_3":"135466.6357","met6KO_6h_1":"195054.4691","met6KO_6h_2":"158544.7607","met6KO_6h_3":"99610.54525","met6KO_15h_1":"166696.1622","met6KO_15h_2":"118237.1282","met6KO_15h_3":"3039198.493"},{"Metabolite":"Glycine","met6KO_0h_1":"39244.21653","met6KO_0h_2":"33776.88712","met6KO_0h_3":"31571.9719","met6KO_2h_1":"39102.52561","met6KO_2h_2":"28702.30232","met6KO_2h_3":"38939.70043","met6KO_4h_1":"35452.4511","met6KO_4h_2":"32281.27242","met6KO_4h_3":"40422.09532","met6KO_6h_1":"30138.53743","met6KO_6h_2":"32766.65106","met6KO_6h_3":"33261.95516","met6KO_15h_1":"35879.346","met6KO_15h_2":"39225.9698","met6KO_15h_3":"28247.89074"},{"Metabolite":"L-Alanine","met6KO_0h_1":"956632.1516","met6KO_0h_2":"2174848.456","met6KO_0h_3":"2868374.626","met6KO_2h_1":"960325.0417","met6KO_2h_2":"1150442.786","met6KO_2h_3":"3903602.289","met6KO_4h_1":"13389626.88","met6KO_4h_2":"22351591.66","met6KO_4h_3":"30727769.27","met6KO_6h_1":"28299322.05","met6KO_6h_2":"27878207.01","met6KO_6h_3":"3844375.233","met6KO_15h_1":"29214946.96","met6KO_15h_2":"21928348.69","met6KO_15h_3":"22258604.69"},{"Metabolite":"Betaine aldehyde","met6KO_0h_1":"244152058.9","met6KO_0h_2":"177027005.6","met6KO_0h_3":"300817001.9","met6KO_2h_1":"208188638.2","met6KO_2h_2":"217241835.9","met6KO_2h_3":"324799595.5","met6KO_4h_1":"229554858.1","met6KO_4h_2":"244270163.4","met6KO_4h_3":"229692666.3","met6KO_6h_1":"186263743.4","met6KO_6h_2":"181002595","met6KO_6h_3":"304167123.9","met6KO_15h_1":"317497870.5","met6KO_15h_2":"310113540.7","met6KO_15h_3":"241625319.1"},{"Metabolite":"Choline","met6KO_0h_1":"3317150.567","met6KO_0h_2":"8296350.888","met6KO_0h_3":"2084853.41","met6KO_2h_1":"4836491.404","met6KO_2h_2":"3654449.353","met6KO_2h_3":"4344764.82","met6KO_4h_1":"2538602.502","met6KO_4h_2":"5380786.709","met6KO_4h_3":"42875422.65","met6KO_6h_1":"4628607.778","met6KO_6h_2":"1753462.403","met6KO_6h_3":"1867362.619","met6KO_15h_1":"12183953.46","met6KO_15h_2":"6458091.295","met6KO_15h_3":"9682907.683"},{"Metabolite":"Gamma-Aminobutyric acid","met6KO_0h_1":"26171.96177","met6KO_0h_2":"35472.43533","met6KO_0h_3":"36895.95577","met6KO_2h_1":"43807.38492","met6KO_2h_2":"59739.54464","met6KO_2h_3":"47242.25519","met6KO_4h_1":"112864.7495","met6KO_4h_2":"243160.8277","met6KO_4h_3":"502103.9979","met6KO_6h_1":"247847.5436","met6KO_6h_2":"275967.3705","met6KO_6h_3":"41308.80013","met6KO_15h_1":"407628.2177","met6KO_15h_2":"310022.4238","met6KO_15h_3":"290775.835"},{"Metabolite":"Dimethylglycine","met6KO_0h_1":"101159.5362","met6KO_0h_2":"95550.8156","met6KO_0h_3":"71254.3111","met6KO_2h_1":"112172.2109","met6KO_2h_2":"90791.75805","met6KO_2h_3":"157642.0257","met6KO_4h_1":"142953.1286","met6KO_4h_2":"224871.355","met6KO_4h_3":"166658.9512","met6KO_6h_1":"312518.9481","met6KO_6h_2":"325801.5117","met6KO_6h_3":"109433.7388","met6KO_15h_1":"736625.738","met6KO_15h_2":"746070.4415","met6KO_15h_3":"604296.4442"},{"Metabolite":"Serine","met6KO_0h_1":"952224.6015","met6KO_0h_2":"1996194.362","met6KO_0h_3":"1841603.73","met6KO_2h_1":"2015972.963","met6KO_2h_2":"2200246.215","met6KO_2h_3":"4465453.747","met6KO_4h_1":"5012648.501","met6KO_4h_2":"7381877.638","met6KO_4h_3":"11567343.15","met6KO_6h_1":"7349741.407","met6KO_6h_2":"8830275.9","met6KO_6h_3":"1971074.022","met6KO_15h_1":"6271578.187","met6KO_15h_2":"6849542.545","met6KO_15h_3":"6528440.317"},{"Metabolite":"Cytosine","met6KO_0h_1":"1072944.178","met6KO_0h_2":"750030.417","met6KO_0h_3":"1123147.933","met6KO_2h_1":"1204583.288","met6KO_2h_2":"837431.7861","met6KO_2h_3":"484458.9229","met6KO_4h_1":"999072.1394","met6KO_4h_2":"1510442.224","met6KO_4h_3":"1131615.792","met6KO_6h_1":"2144625.447","met6KO_6h_2":"1212842.986","met6KO_6h_3":"560022.7367","met6KO_15h_1":"730158.1981","met6KO_15h_2":"1017927.636","met6KO_15h_3":"721616.4508"},{"Metabolite":"Creatinine","met6KO_0h_1":"375608.9844","met6KO_0h_2":"1692319.768","met6KO_0h_3":"404931.1375","met6KO_2h_1":"712550.2096","met6KO_2h_2":"784232.8963","met6KO_2h_3":"653854.8255","met6KO_4h_1":"317390.6941","met6KO_4h_2":"829007.4337","met6KO_4h_3":"4740648.71","met6KO_6h_1":"610424.1131","met6KO_6h_2":"482183.3784","met6KO_6h_3":"537827.9191","met6KO_15h_1":"789652.6183","met6KO_15h_2":"645298.2072","met6KO_15h_3":"1195122.537"},{"Metabolite":"L-Proline","met6KO_0h_1":"5582870.113","met6KO_0h_2":"14325150.33","met6KO_0h_3":"11617836.33","met6KO_2h_1":"10858571.99","met6KO_2h_2":"13122305.13","met6KO_2h_3":"35074727.88","met6KO_4h_1":"124477834.6","met6KO_4h_2":"158576883.4","met6KO_4h_3":"241977530.2","met6KO_6h_1":"231683793.4","met6KO_6h_2":"178958666","met6KO_6h_3":"14807968.76","met6KO_15h_1":"296254583.8","met6KO_15h_2":"280790796.8","met6KO_15h_3":"238045883.3"},{"Metabolite":"Indole","met6KO_0h_1":"39480.15191","met6KO_0h_2":"74340.51011","met6KO_0h_3":"72957.13317","met6KO_2h_1":"132185.2835","met6KO_2h_2":"143199.2753","met6KO_2h_3":"400063.9467","met6KO_4h_1":"740908.0804","met6KO_4h_2":"881547.2784","met6KO_4h_3":"1129810.524","met6KO_6h_1":"918372.174","met6KO_6h_2":"1086412.834","met6KO_6h_3":"65855.69715","met6KO_15h_1":"893443.3281","met6KO_15h_2":"900879.2205","met6KO_15h_3":"889721.566"},{"Metabolite":"Betaine","met6KO_0h_1":"41355005.88","met6KO_0h_2":"54431660.69","met6KO_0h_3":"103430682.9","met6KO_2h_1":"48757033.6","met6KO_2h_2":"58340840.01","met6KO_2h_3":"41746853.57","met6KO_4h_1":"36455168.25","met6KO_4h_2":"96431439.92","met6KO_4h_3":"755099863.5","met6KO_6h_1":"66046712.61","met6KO_6h_2":"43602014.81","met6KO_6h_3":"31525979.87","met6KO_15h_1":"137805141.6","met6KO_15h_2":"202768772.8","met6KO_15h_3":"92261437.39"},{"Metabolite":"L-Valine","met6KO_0h_1":"39140.77515","met6KO_0h_2":"158515.3151","met6KO_0h_3":"87763.62857","met6KO_2h_1":"316228.9939","met6KO_2h_2":"337917.9137","met6KO_2h_3":"1248155.033","met6KO_4h_1":"2972319.025","met6KO_4h_2":"3788638.242","met6KO_4h_3":"4896559.025","met6KO_6h_1":"5016900.235","met6KO_6h_2":"5517450.458","met6KO_6h_3":"92990.18168","met6KO_15h_1":"6580029.567","met6KO_15h_2":"5514710.718","met6KO_15h_3":"5532159.901"},{"Metabolite":"L-Threonine","met6KO_0h_1":"1698833.618","met6KO_0h_2":"4059408.111","met6KO_0h_3":"4872451.976","met6KO_2h_1":"3308171.013","met6KO_2h_2":"3377492.378","met6KO_2h_3":"8720692.11","met6KO_4h_1":"18989435.57","met6KO_4h_2":"24270588.15","met6KO_4h_3":"31075161.91","met6KO_6h_1":"31350617.01","met6KO_6h_2":"34007310.16","met6KO_6h_3":"5027611.601","met6KO_15h_1":"46808270.86","met6KO_15h_2":"37407059.17","met6KO_15h_3":"38228009.35"},{"Metabolite":"L-Homoserine","met6KO_0h_1":"80533.34135","met6KO_0h_2":"155321.9047","met6KO_0h_3":"276030.1466","met6KO_2h_1":"54410.70444","met6KO_2h_2":"49678.06505","met6KO_2h_3":"125856.6843","met6KO_4h_1":"197836.8176","met6KO_4h_2":"313468.7032","met6KO_4h_3":"278300.9337","met6KO_6h_1":"358714.0333","met6KO_6h_2":"395086.4386","met6KO_6h_3":"239776.8547","met6KO_15h_1":"310574.8862","met6KO_15h_2":"265426.9216","met6KO_15h_3":"220251.4212"},{"Metabolite":"Purine","met6KO_0h_1":"70245.18373","met6KO_0h_2":"194818.2319","met6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dimethylarginine"},{"metabolite_name":"L-Acetylcarnitine"},{"metabolite_name":"L-Tryptophan"},{"metabolite_name":"L-Kynurenine"},{"metabolite_name":"N-Acetyl-D-glucosamine"},{"metabolite_name":"Flavone"},{"metabolite_name":"L-Cystathionine"},{"metabolite_name":"5-Methoxytryptophan"},{"metabolite_name":"L-Cystine"},{"metabolite_name":"Cytidine"},{"metabolite_name":"Biotin"},{"metabolite_name":"Deoxyadenosine"},{"metabolite_name":"Glycerophosphocholine"},{"metabolite_name":"AICA-riboside"},{"metabolite_name":"Glucosamine 6-phosphate"},{"metabolite_name":"Glucosamine-1P"},{"metabolite_name":"Thiamine"},{"metabolite_name":"S-Ribosyl-L-homocysteine"},{"metabolite_name":"Deoxyguanosine"},{"metabolite_name":"Adenosine"},{"metabolite_name":"1-Methyladenosine"},{"metabolite_name":"Guanosine"},{"metabolite_name":"Argininosuccinic acid"},{"metabolite_name":"5'-Methylthioadenosine"},{"metabolite_name":"7-Methylguanosine"},{"metabolite_name":"dCMP"},{"metabolite_name":"Glutathione"},{"metabolite_name":"5-Thymidylic acid"},{"metabolite_name":"Cytidine monophosphate"},{"metabolite_name":"Uridine 5'-monophosphate"},{"metabolite_name":"Deoxyadenosine monophosphate"},{"metabolite_name":"Nicotinamide ribotide"},{"metabolite_name":"AICAR"},{"metabolite_name":"Thiamine monophosphate"},{"metabolite_name":"dGMP"},{"metabolite_name":"Adenosine monophosphate"},{"metabolite_name":"IMP"},{"metabolite_name":"S-Adenosylmethioninamine"},{"metabolite_name":"GMP"},{"metabolite_name":"Xanthylic acid"},{"metabolite_name":"Riboflavin"},{"metabolite_name":"S-Adenosylhomocysteine"},{"metabolite_name":"S-Adenosylmethionine"},{"metabolite_name":"Folic acid"},{"metabolite_name":"Dihydrofolic acid"},{"metabolite_name":"5-Methyltetrahydrofolic acid"},{"metabolite_name":"3,5-Diiodothyronine"},{"metabolite_name":"Oxidized glutathione"},{"metabolite_name":"NAD"},{"metabolite_name":"NADH"},{"metabolite_name":"Dephospho-CoA"},{"metabolite_name":"NADP"},{"metabolite_name":"NADPH"},{"metabolite_name":"Coenzyme A"},{"metabolite_name":"FAD"},{"metabolite_name":"Acetyl-CoA"},{"metabolite_name":"Propionyl-CoA"},{"metabolite_name":"Acetoacetyl-CoA"},{"metabolite_name":"Malonyl-CoA"},{"metabolite_name":"Succinyl-CoA"},{"metabolite_name":"Putrescine"},{"metabolite_name":"Spermidine"},{"metabolite_name":"Spermine"},{"metabolite_name":"Sarcosine"},{"metabolite_name":"13C-Proline1"},{"metabolite_name":"13C-Alanine-1"},{"metabolite_name":"13C-Serine-1"},{"metabolite_name":"13C-Threonine-1"},{"metabolite_name":"13C-Valine-1"},{"metabolite_name":"13C-Glycine-1"},{"metabolite_name":"13C-Aspartate-1"},{"metabolite_name":"13C-Arginine-1"},{"metabolite_name":"13C-Cystine-1"},{"metabolite_name":"13C-Glutamic acid-1"},{"metabolite_name":"13C-Histidine-1"},{"metabolite_name":"13C-Iso Leucine-1"},{"metabolite_name":"13C-Lysine-1"},{"metabolite_name":"13C-Methionine-1"},{"metabolite_name":"13C-Phenylalanine-1"},{"metabolite_name":"13C-Tyrosine"},{"metabolite_name":"13C valine-1"},{"metabolite_name":"13C tyrosine"},{"metabolite_name":"13 C phenylalanine"},{"metabolite_name":"13C lysine"}]
}

}