{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002584","ANALYSIS_ID":"AN004256","VERSION":"1","CREATED_ON":"April 26, 2023, 11:57 am"},

"PROJECT":{"PROJECT_TITLE":"Metabolomics analysis of ALDH1L1-expressing HuH-7 cell line.","PROJECT_SUMMARY":"Quantitative metabolomics study of the effect of the folate metabolizing enzyme ALDH1L1 on the HuH-7 cell line.","INSTITUTE":"Tohoku Medical and Pharmaceutical University","LAST_NAME":"Sasaki","FIRST_NAME":"Masato","ADDRESS":"4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan","EMAIL":"msasaki@tohoku-mpu.ac.jp","PHONE":"+81-22-727-0132"},

"STUDY":{"STUDY_TITLE":"Metabolomics analysis of ALDH1L1-expressing HuH7 cell lines.","STUDY_SUMMARY":"One-carbon metabolism is utilized for the de novo synthesis of purines. Given that tumor cells require large amounts of nucleotides, they are highly dependent on one-carbon metabolism. Among the one-carbon-metabolizing enzymes, the aldehyde dehydrogenase 1 family member L1 (ALDH1L1), which catalyzes 10-formyltetrahydrofolate to trahydrofolate, is considered a tumor suppressor gene, as its expression is reported to be attenuated or diminished in hepatocellular carcinoma. To clarify the effect of ALDH1L1 expression, we generated control and ALDH1L1-expressing HuH-7 (H7-1L1) cells, and measured the amounts of intracellular metabolites in both control and ALDH1L1-expressing by CE-TOFMS analysis.","INSTITUTE":"Tohoku Medical and Pharmaceutical University","LAST_NAME":"Sasaki","FIRST_NAME":"Masato","ADDRESS":"4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan","EMAIL":"msasaki@tohoku-mpu.ac.jp","PHONE":"+81-22-727-0132"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"L1-1",
"Sample ID":"L1-1",
"Factors":{"Transgene":"ALDH1L1"},
"Additional sample data":{"RAW_FILE_NAME":"L1-1"}
},
{
"Subject ID":"L1-2",
"Sample ID":"L1-2",
"Factors":{"Transgene":"ALDH1L1"},
"Additional sample data":{"RAW_FILE_NAME":"L1-2"}
},
{
"Subject ID":"L1-3",
"Sample ID":"L1-3",
"Factors":{"Transgene":"ALDH1L1"},
"Additional sample data":{"RAW_FILE_NAME":"L1-3"}
},
{
"Subject ID":"C-1",
"Sample ID":"C-1",
"Factors":{"Transgene":"empty"},
"Additional sample data":{"RAW_FILE_NAME":"C-1"}
},
{
"Subject ID":"C-2",
"Sample ID":"C-2",
"Factors":{"Transgene":"empty"},
"Additional sample data":{"RAW_FILE_NAME":"C-2"}
},
{
"Subject ID":"C-3",
"Sample ID":"C-3",
"Factors":{"Transgene":"empty"},
"Additional sample data":{"RAW_FILE_NAME":"C-3"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"ALDH1L1-expressing cells or control (empty vector) cells were cultured in DMEM medium containing 5% fetal bovine serum and metabolites were collected during growing phase.","SAMPLE_TYPE":"HuH-7 cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"No treatment in this study."},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Cells were washed with 5%(w/w) mannitol solution, and then extracted with methanol. Extracts were filtered through a 5-kDa cut-off filter (Ultrafree-MC-PLHCC, Human Metabolome Technologies) at 9,100 × g for 2 h at 4 °C, dried in a centrifugal evaporator at 1,500 rpm at 1,000 Pa, and resuspended in 50 μl of ultrapure water before metabolome analysis."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"CE-TOFMS (ESI negative)","CHROMATOGRAPHY_TYPE":"CE","INSTRUMENT_NAME":"Agilent CE","COLUMN_NAME":"Agilent Fused silica capillary (80cm x 50um)","SOLVENT_A":"50 mM ammonium acetate","SOLVENT_B":"-","FLOW_GRADIENT":"-","FLOW_RATE":"−30 kV","COLUMN_TEMPERATURE":"20"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent CE-TOFMS","INSTRUMENT_TYPE":"Other","MS_TYPE":"ESI","ION_MODE":"NEGATIVE","MS_COMMENTS":"The spectrometer was scanned from m/z 50 to 1,000. Peaks were extracted using automatic integration software MasterHands (ver.2.16.0.15 Keio University). Signal peaks corresponding to isotopomers, adduct ions, and other product ions of known metabolites were excluded, and remaining peaks were annotated with putative metabolites from the HMT metabolite database based on their migration time and m/z values. Peak areas were normalized to internal standards and sample amounts."},

"MS_METABOLITE_DATA":{
"Units":"Relative Area",

"Data":[{"Metabolite":"Urea","L1-1":"2.4E-01","L1-2":"2.4E-01","L1-3":"1.8E-01","C-1":"2.3E-01","C-2":"1.9E-01","C-3":"1.9E-01"},{"Metabolite":"Ethanolamine","L1-1":"N.D.","L1-2":"N.D.","L1-3":"N.D.","C-1":"3.9E-03","C-2":"3.2E-03","C-3":"2.9E-03"},{"Metabolite":"Aminoacetone","L1-1":"1.9E-02","L1-2":"1.6E-02","L1-3":"1.9E-02","C-1":"2.2E-02","C-2":"2.0E-02","C-3":"1.9E-02"},{"Metabolite":"Gly","L1-1":"5.6E+00","L1-2":"5.8E+00","L1-3":"5.6E+00","C-1":"4.9E+00","C-2":"5.0E+00","C-3":"5.1E+00"},{"Metabolite":"Trimethylamine N-oxide","L1-1":"3.7E-03","L1-2":"3.8E-03","L1-3":"3.8E-03","C-1":"3.9E-03","C-2":"4.2E-03","C-3":"3.5E-03"},{"Metabolite":"Putrescine","L1-1":"1.2E-02","L1-2":"1.0E-02","L1-3":"1.0E-02","C-1":"1.2E-02","C-2":"1.2E-02","C-3":"1.1E-02"},{"Metabolite":"β-Ala","L1-1":"1.2E+00","L1-2":"1.3E+00","L1-3":"1.2E+00","C-1":"1.2E+00","C-2":"1.3E+00","C-3":"1.3E+00"},{"Metabolite":"Ala","L1-1":"6.5E+00","L1-2":"7.0E+00","L1-3":"7.0E+00","C-1":"6.4E+00","C-2":"6.8E+00","C-3":"6.8E+00"},{"Metabolite":"Glycerol","L1-1":"1.3E+00","L1-2":"1.8E+00","L1-3":"1.4E+00","C-1":"1.3E+00","C-2":"1.5E+00","C-3":"1.6E+00"},{"Metabolite":"1-Aminocyclopropane-1-carboxylic acid / Homoserinelactone","L1-1":"7.0E-03","L1-2":"7.4E-03","L1-3":"6.3E-03","C-1":"8.2E-03","C-2":"6.2E-03","C-3":"6.0E-03"},{"Metabolite":"3-Aminoisobutyric acid","L1-1":"1.3E-02","L1-2":"1.4E-02","L1-3":"2.0E-02","C-1":"1.4E-02","C-2":"1.9E-02","C-3":"1.7E-02"},{"Metabolite":"2-Aminoisobutyric acid / 2-Aminobutyric acid","L1-1":"8.2E-02","L1-2":"7.8E-02","L1-3":"7.9E-02","C-1":"8.3E-02","C-2":"9.1E-02","C-3":"8.3E-02"},{"Metabolite":"GABA","L1-1":"1.7E-01","L1-2":"2.0E-01","L1-3":"2.1E-01","C-1":"2.3E-01","C-2":"2.4E-01","C-3":"2.5E-01"},{"Metabolite":"Choline","L1-1":"1.2E-01","L1-2":"1.2E-01","L1-3":"1.2E-01","C-1":"1.2E-01","C-2":"1.3E-01","C-3":"1.2E-01"},{"Metabolite":"Ser","L1-1":"1.6E+00","L1-2":"1.6E+00","L1-3":"1.4E+00","C-1":"2.3E+00","C-2":"2.3E+00","C-3":"2.3E+00"},{"Metabolite":"Diethanolamine","L1-1":"1.7E-02","L1-2":"1.7E-02","L1-3":"1.8E-02","C-1":"3.3E-01","C-2":"3.4E-02","C-3":"2.9E-02"},{"Metabolite":"Hypotaurine","L1-1":"2.7E-01","L1-2":"3.0E-01","L1-3":"3.0E-01","C-1":"2.5E-01","C-2":"2.9E-01","C-3":"2.6E-01"},{"Metabolite":"1-Pyrroline 5-carboxylic acid","L1-1":"5.4E-02","L1-2":"7.6E-02","L1-3":"7.5E-02","C-1":"5.6E-02","C-2":"8.4E-02","C-3":"8.3E-02"},{"Metabolite":"Creatinine","L1-1":"2.9E-02","L1-2":"2.8E-02","L1-3":"2.7E-02","C-1":"2.9E-02","C-2":"2.8E-02","C-3":"2.9E-02"},{"Metabolite":"Pro","L1-1":"4.0E-01","L1-2":"4.5E-01","L1-3":"4.3E-01","C-1":"4.1E-01","C-2":"4.3E-01","C-3":"4.4E-01"},{"Metabolite":"5-Aminovaleric acid","L1-1":"1.9E-02","L1-2":"1.9E-02","L1-3":"1.8E-02","C-1":"1.8E-02","C-2":"1.9E-02","C-3":"1.9E-02"},{"Metabolite":"Betaine","L1-1":"1.0E-01","L1-2":"1.2E-01","L1-3":"1.1E-01","C-1":"1.1E-01","C-2":"1.1E-01","C-3":"1.1E-01"},{"Metabolite":"Val","L1-1":"4.8E+00","L1-2":"4.7E+00","L1-3":"4.1E+00","C-1":"4.8E+00","C-2":"4.5E+00","C-3":"4.6E+00"},{"Metabolite":"Thr","L1-1":"7.1E+00","L1-2":"7.4E+00","L1-3":"7.0E+00","C-1":"7.5E+00","C-2":"7.5E+00","C-3":"7.4E+00"},{"Metabolite":"Homoserine","L1-1":"4.2E-03","L1-2":"5.2E-03","L1-3":"N.D.","C-1":"6.0E-03","C-2":"5.3E-03","C-3":"5.3E-03"},{"Metabolite":"Cys","L1-1":"1.4E-02","L1-2":"2.8E-02","L1-3":"8.4E-03","C-1":"1.9E-02","C-2":"8.0E-03","C-3":"2.6E-02"},{"Metabolite":"Nicotinamide","L1-1":"3.8E-02","L1-2":"4.3E-02","L1-3":"4.8E-02","C-1":"4.0E-02","C-2":"3.4E-02","C-3":"4.1E-02"},{"Metabolite":"Taurine","L1-1":"4.3E-02","L1-2":"4.0E-02","L1-3":"4.3E-02","C-1":"4.1E-02","C-2":"4.2E-02","C-3":"4.2E-02"},{"Metabolite":"Imidazole-4-acetic acid","L1-1":"N.D.","L1-2":"N.D.","L1-3":"N.D.","C-1":"N.D.","C-2":"N.D.","C-3":"N.D."},{"Metabolite":"1-Aminocyclopentanecarboxylic acid","L1-1":"8.2E-03","L1-2":"8.3E-03","L1-3":"7.3E-03","C-1":"7.5E-03","C-2":"7.6E-03","C-3":"7.4E-03"},{"Metabolite":"Pipecolic acid","L1-1":"2.4E-03","L1-2":"2.3E-03","L1-3":"2.2E-03","C-1":"N.D.","C-2":"2.3E-03","C-3":"2.6E-03"},{"Metabolite":"trans-Glutaconic acid","L1-1":"1.1E-02","L1-2":"1.4E-02","L1-3":"1.3E-02","C-1":"1.3E-02","C-2":"1.3E-02","C-3":"1.3E-02"},{"Metabolite":"N-Acetylputrescine","L1-1":"2.5E-03","L1-2":"2.9E-03","L1-3":"2.2E-03","C-1":"3.3E-03","C-2":"3.0E-03","C-3":"1.8E-03"},{"Metabolite":"Hydroxyproline","L1-1":"1.7E-01","L1-2":"1.9E-01","L1-3":"1.9E-01","C-1":"1.8E-01","C-2":"1.9E-01","C-3":"1.8E-01"},{"Metabolite":"cis-4-Hydroxyproline","L1-1":"2.6E-02","L1-2":"3.9E-02","L1-3":"3.7E-02","C-1":"3.0E-02","C-2":"3.8E-02","C-3":"4.0E-02"},{"Metabolite":"Creatine","L1-1":"3.4E-01","L1-2":"4.2E-01","L1-3":"4.7E-01","C-1":"3.4E-01","C-2":"3.8E-01","C-3":"3.9E-01"},{"Metabolite":"Ile","L1-1":"5.6E+00","L1-2":"5.3E+00","L1-3":"4.8E+00","C-1":"5.7E+00","C-2":"5.4E+00","C-3":"5.3E+00"},{"Metabolite":"Leu","L1-1":"6.2E+00","L1-2":"6.0E+00","L1-3":"5.6E+00","C-1":"6.5E+00","C-2":"6.3E+00","C-3":"6.2E+00"},{"Metabolite":"Asn","L1-1":"4.9E-01","L1-2":"5.2E-01","L1-3":"5.0E-01","C-1":"4.4E-01","C-2":"4.6E-01","C-3":"4.7E-01"},{"Metabolite":"Gly-Gly","L1-1":"2.3E-02","L1-2":"2.6E-02","L1-3":"2.4E-02","C-1":"2.7E-02","C-2":"2.6E-02","C-3":"2.7E-02"},{"Metabolite":"Ornithine","L1-1":"1.9E-01","L1-2":"2.0E-01","L1-3":"2.3E-01","C-1":"2.1E-01","C-2":"2.4E-01","C-3":"2.3E-01"},{"Metabolite":"Thiaproline","L1-1":"1.9E-02","L1-2":"1.5E-02","L1-3":"9.1E-03","C-1":"2.4E-02","C-2":"1.2E-02","C-3":"1.6E-02"},{"Metabolite":"Asp","L1-1":"7.3E+00","L1-2":"7.7E+00","L1-3":"7.2E+00","C-1":"7.5E+00","C-2":"7.6E+00","C-3":"7.5E+00"},{"Metabolite":"Adenine","L1-1":"5.2E-03","L1-2":"4.4E-03","L1-3":"5.5E-03","C-1":"5.1E-03","C-2":"4.8E-03","C-3":"4.4E-03"},{"Metabolite":"1-Methylnicotinamide","L1-1":"2.9E-02","L1-2":"3.2E-02","L1-3":"3.0E-02","C-1":"3.4E-02","C-2":"3.4E-02","C-3":"3.2E-02"},{"Metabolite":"Urocanic acid","L1-1":"N.D.","L1-2":"N.D.","L1-3":"N.D.","C-1":"N.D.","C-2":"N.D.","C-3":"N.D."},{"Metabolite":"1-Methyl-4-imidazoleacetic acid","L1-1":"2.0E-03","L1-2":"2.6E-03","L1-3":"2.0E-03","C-1":"2.1E-03","C-2":"N.D.","C-3":"2.1E-03"},{"Metabolite":"1H-Imidazole-4-propionic acid","L1-1":"2.4E-03","L1-2":"2.7E-03","L1-3":"2.7E-03","C-1":"N.D.","C-2":"2.6E-03","C-3":"2.0E-03"},{"Metabolite":"γ-Butyrobetaine","L1-1":"3.9E-02","L1-2":"4.4E-02","L1-3":"4.2E-02","C-1":"4.2E-02","C-2":"4.4E-02","C-3":"4.2E-02"},{"Metabolite":"Spermidine","L1-1":"2.9E-02","L1-2":"3.9E-02","L1-3":"3.7E-02","C-1":"2.8E-02","C-2":"3.7E-02","C-3":"3.8E-02"},{"Metabolite":"Lys","L1-1":"1.2E+00","L1-2":"1.2E+00","L1-3":"1.1E+00","C-1":"1.4E+00","C-2":"1.2E+00","C-3":"1.1E+00"},{"Metabolite":"N-Acetylserine","L1-1":"6.1E-02","L1-2":"5.7E-02","L1-3":"5.4E-02","C-1":"5.4E-02","C-2":"5.1E-02","C-3":"5.6E-02"},{"Metabolite":"Gln","L1-1":"6.8E-01","L1-2":"6.4E-01","L1-3":"5.9E-01","C-1":"6.7E-01","C-2":"6.2E-01","C-3":"6.2E-01"},{"Metabolite":"Glu","L1-1":"1.3E+00","L1-2":"1.4E+00","L1-3":"1.3E+00","C-1":"1.3E+00","C-2":"1.4E+00","C-3":"1.4E+00"},{"Metabolite":"Met","L1-1":"8.9E-01","L1-2":"9.8E-01","L1-3":"1.0E+00","C-1":"9.7E-01","C-2":"1.1E+00","C-3":"9.1E-01"},{"Metabolite":"Octopamine / Dopamine","L1-1":"4.0E-03","L1-2":"3.7E-03","L1-3":"3.4E-03","C-1":"4.5E-03","C-2":"3.4E-03","C-3":"3.2E-03"},{"Metabolite":"His","L1-1":"1.4E+00","L1-2":"1.4E+00","L1-3":"1.3E+00","C-1":"1.4E+00","C-2":"1.4E+00","C-3":"1.3E+00"},{"Metabolite":"O-Acetylhomoserine / 2-Aminoadipic acid","L1-1":"5.7E-02","L1-2":"6.3E-02","L1-3":"5.1E-02","C-1":"6.3E-02","C-2":"6.7E-02","C-3":"6.6E-02"},{"Metabolite":"Carnitine","L1-1":"1.1E-01","L1-2":"1.2E-01","L1-3":"1.3E-01","C-1":"1.2E-01","C-2":"1.4E-01","C-3":"1.3E-01"},{"Metabolite":"5-Hydroxylysine","L1-1":"N.D.","L1-2":"9.5E-04","L1-3":"1.2E-03","C-1":"N.D.","C-2":"N.D.","C-3":"8.9E-04"},{"Metabolite":"Methionine sulfoxide","L1-1":"4.6E-02","L1-2":"3.9E-02","L1-3":"2.3E-02","C-1":"4.0E-02","C-2":"2.2E-02","C-3":"3.6E-02"},{"Metabolite":"Phe","L1-1":"4.5E+00","L1-2":"4.4E+00","L1-3":"4.1E+00","C-1":"4.3E+00","C-2":"4.3E+00","C-3":"4.1E+00"},{"Metabolite":"Pyridoxal","L1-1":"6.0E-03","L1-2":"6.6E-03","L1-3":"9.5E-03","C-1":"5.2E-03","C-2":"8.5E-03","C-3":"7.5E-03"},{"Metabolite":"Pyridoxine","L1-1":"5.6E-02","L1-2":"4.9E-02","L1-3":"3.8E-02","C-1":"6.1E-02","C-2":"4.1E-02","C-3":"4.2E-02"},{"Metabolite":"1-Methylhistidine / 3-Methylhistidine","L1-1":"2.9E-02","L1-2":"3.2E-02","L1-3":"3.1E-02","C-1":"3.1E-02","C-2":"3.1E-02","C-3":"3.2E-02"},{"Metabolite":"N5-Ethylglutamine","L1-1":"1.4E-02","L1-2":"1.3E-02","L1-3":"1.4E-02","C-1":"1.4E-02","C-2":"1.5E-02","C-3":"1.5E-02"},{"Metabolite":"Arg","L1-1":"5.9E-01","L1-2":"5.5E-01","L1-3":"4.8E-01","C-1":"5.9E-01","C-2":"5.5E-01","C-3":"5.0E-01"},{"Metabolite":"Diethylaminomalonic acid","L1-1":"9.4E-03","L1-2":"9.8E-03","L1-3":"7.6E-03","C-1":"9.3E-03","C-2":"1.0E-02","C-3":"9.6E-03"},{"Metabolite":"Citrulline","L1-1":"6.5E-02","L1-2":"6.7E-02","L1-3":"6.1E-02","C-1":"6.4E-02","C-2":"6.5E-02","C-3":"6.8E-02"},{"Metabolite":"Cys-Gly","L1-1":"1.7E-03","L1-2":"2.1E-03","L1-3":"N.D.","C-1":"1.8E-03","C-2":"N.D.","C-3":"4.3E-03"},{"Metabolite":"Gluconolactone","L1-1":"1.8E-02","L1-2":"1.5E-02","L1-3":"1.4E-02","C-1":"1.5E-02","C-2":"1.3E-02","C-3":"1.4E-02"},{"Metabolite":"Galactosamine / Glucosamine","L1-1":"N.D.","L1-2":"9.7E-04","L1-3":"N.D.","C-1":"1.1E-03","C-2":"N.D.","C-3":"N.D."},{"Metabolite":"N-Methylnorsalsolinol","L1-1":"3.0E-03","L1-2":"2.6E-03","L1-3":"3.0E-03","C-1":"2.4E-03","C-2":"3.1E-03","C-3":"4.1E-03"},{"Metabolite":"Tyr","L1-1":"2.9E+00","L1-2":"3.0E+00","L1-3":"2.7E+00","C-1":"2.9E+00","C-2":"2.9E+00","C-3":"2.8E+00"},{"Metabolite":"Phosphorylcholine","L1-1":"6.0E+00","L1-2":"5.8E+00","L1-3":"5.3E+00","C-1":"4.8E+00","C-2":"4.6E+00","C-3":"4.6E+00"},{"Metabolite":"N8-Acetylspermidine","L1-1":"1.1E-02","L1-2":"1.2E-02","L1-3":"9.4E-03","C-1":"7.5E-03","C-2":"8.1E-03","C-3":"8.4E-03"},{"Metabolite":"Gly-Leu","L1-1":"N.D.","L1-2":"N.D.","L1-3":"3.3E-03","C-1":"N.D.","C-2":"3.4E-03","C-3":"N.D."},{"Metabolite":"N-Acetyllysine","L1-1":"3.8E-03","L1-2":"5.1E-03","L1-3":"4.1E-03","C-1":"3.8E-03","C-2":"5.7E-03","C-3":"5.2E-03"},{"Metabolite":"N6-Acetyllysine","L1-1":"N.D.","L1-2":"2.9E-03","L1-3":"3.9E-03","C-1":"2.9E-03","C-2":"N.D.","C-3":"3.9E-03"},{"Metabolite":"Homocitrulline","L1-1":"N.D.","L1-2":"N.D.","L1-3":"3.1E-03","C-1":"2.9E-03","C-2":"3.5E-03","C-3":"N.D."},{"Metabolite":"Gly-Asp","L1-1":"6.5E-02","L1-2":"6.7E-02","L1-3":"6.6E-02","C-1":"6.3E-02","C-2":"6.7E-02","C-3":"7.0E-02"},{"Metabolite":"Tyrosine methyl 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"Metabolites":[{"metabolite_name":"Urea"},{"metabolite_name":"Ethanolamine"},{"metabolite_name":"Aminoacetone"},{"metabolite_name":"Gly"},{"metabolite_name":"Trimethylamine N-oxide"},{"metabolite_name":"Putrescine"},{"metabolite_name":"β-Ala"},{"metabolite_name":"Ala"},{"metabolite_name":"Glycerol"},{"metabolite_name":"1-Aminocyclopropane-1-carboxylic acid / Homoserinelactone"},{"metabolite_name":"3-Aminoisobutyric acid"},{"metabolite_name":"2-Aminoisobutyric acid / 2-Aminobutyric acid"},{"metabolite_name":"GABA"},{"metabolite_name":"Choline"},{"metabolite_name":"Ser"},{"metabolite_name":"Diethanolamine"},{"metabolite_name":"Hypotaurine"},{"metabolite_name":"1-Pyrroline 5-carboxylic acid"},{"metabolite_name":"Creatinine"},{"metabolite_name":"Pro"},{"metabolite_name":"5-Aminovaleric acid"},{"metabolite_name":"Betaine"},{"metabolite_name":"Val"},{"metabolite_name":"Thr"},{"metabolite_name":"Homoserine"},{"metabolite_name":"Cys"},{"metabolite_name":"Nicotinamide"},{"metabolite_name":"Taurine"},{"metabolite_name":"Imidazole-4-acetic acid"},{"metabolite_name":"1-Aminocyclopentanecarboxylic acid"},{"metabolite_name":"Pipecolic acid"},{"metabolite_name":"trans-Glutaconic acid"},{"metabolite_name":"N-Acetylputrescine"},{"metabolite_name":"Hydroxyproline"},{"metabolite_name":"cis-4-Hydroxyproline"},{"metabolite_name":"Creatine"},{"metabolite_name":"Ile"},{"metabolite_name":"Leu"},{"metabolite_name":"Asn"},{"metabolite_name":"Gly-Gly"},{"metabolite_name":"Ornithine"},{"metabolite_name":"Thiaproline"},{"metabolite_name":"Asp"},{"metabolite_name":"Adenine"},{"metabolite_name":"1-Methylnicotinamide"},{"metabolite_name":"Urocanic acid"},{"metabolite_name":"1-Methyl-4-imidazoleacetic acid"},{"metabolite_name":"1H-Imidazole-4-propionic acid"},{"metabolite_name":"γ-Butyrobetaine"},{"metabolite_name":"Spermidine"},{"metabolite_name":"Lys"},{"metabolite_name":"N-Acetylserine"},{"metabolite_name":"Gln"},{"metabolite_name":"Glu"},{"metabolite_name":"Met"},{"metabolite_name":"Octopamine / Dopamine"},{"metabolite_name":"His"},{"metabolite_name":"O-Acetylhomoserine / 2-Aminoadipic acid"},{"metabolite_name":"Carnitine"},{"metabolite_name":"5-Hydroxylysine"},{"metabolite_name":"Methionine sulfoxide"},{"metabolite_name":"Phe"},{"metabolite_name":"Pyridoxal"},{"metabolite_name":"Pyridoxine"},{"metabolite_name":"1-Methylhistidine / 3-Methylhistidine"},{"metabolite_name":"N5-Ethylglutamine"},{"metabolite_name":"Arg"},{"metabolite_name":"Diethylaminomalonic acid"},{"metabolite_name":"Citrulline"},{"metabolite_name":"Cys-Gly"},{"metabolite_name":"Gluconolactone"},{"metabolite_name":"Galactosamine / Glucosamine"},{"metabolite_name":"N-Methylnorsalsolinol"},{"metabolite_name":"Tyr"},{"metabolite_name":"Phosphorylcholine"},{"metabolite_name":"N8-Acetylspermidine"},{"metabolite_name":"Gly-Leu"},{"metabolite_name":"N-Acetyllysine"},{"metabolite_name":"N6-Acetyllysine"},{"metabolite_name":"Homocitrulline"},{"metabolite_name":"Gly-Asp"},{"metabolite_name":"Tyrosine methyl ester"},{"metabolite_name":"DOPA"},{"metabolite_name":"SDMA"},{"metabolite_name":"ADMA"},{"metabolite_name":"Spermine"},{"metabolite_name":"O-Acetylcarnitine"},{"metabolite_name":"Trp"},{"metabolite_name":"Carboxymethyllysine"},{"metabolite_name":"Kynurenine"},{"metabolite_name":"β-Ala-Lys"},{"metabolite_name":"N-Acetylgalactosamine/N-Acetylmannosamine/N-Acetylglucosamine"},{"metabolite_name":"Cystathionine"},{"metabolite_name":"Carnosine"},{"metabolite_name":"2'-Deoxycytidine"},{"metabolite_name":"Butyrylcarnitine"},{"metabolite_name":"Thr-Asp"},{"metabolite_name":"Ser-Glu"},{"metabolite_name":"7,8-Dihydrobiopterin"},{"metabolite_name":"Ribavirin"},{"metabolite_name":"Isovalerylcarnitine"},{"metabolite_name":"γ-Glu-Cys"},{"metabolite_name":"Glycerophosphocholine"},{"metabolite_name":"Thiamine"},{"metabolite_name":"Adenosine"},{"metabolite_name":"Inosine"},{"metabolite_name":"Saccharopine"},{"metabolite_name":"1-Methyladenosine"},{"metabolite_name":"Guanosine"},{"metabolite_name":"His-Glu"},{"metabolite_name":"Ophthalmic acid"},{"metabolite_name":"Argininosuccinic acid"},{"metabolite_name":"5'-Deoxy-5'-methylthioadenosine"},{"metabolite_name":"Arg-Glu"},{"metabolite_name":"Glutathione (GSSG)_divalent"},{"metabolite_name":"Glutathione (GSH)"},{"metabolite_name":"S-Methylglutathione"},{"metabolite_name":"S-Nitrosoglutathione"},{"metabolite_name":"Thiamine phosphate"},{"metabolite_name":"Gibberellic acid"},{"metabolite_name":"S-Lactoylglutathione"},{"metabolite_name":"S-Adenosylhomocysteine"},{"metabolite_name":"S-Adenosylmethionine"},{"metabolite_name":"Cysteine glutathione disulfide"},{"metabolite_name":"Folic acid"}]
}

}