{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002856","ANALYSIS_ID":"AN004678","VERSION":"1","CREATED_ON":"September 12, 2023, 2:49 pm"},

"PROJECT":{"PROJECT_TITLE":"MYC is a regulator of AR inhibition-induced metabolic requirements in prostate cancer","PROJECT_SUMMARY":"Advanced prostate cancers are treated with therapies targeting the androgen receptor (AR) signaling pathway. While many tumors initially respond to AR inhibition, nearly all develop resistance. It is critical to understand how prostate tumor cells respond to AR inhibition in order to exploit therapy-induced phenotypes prior to the outgrowth of treatment-resistant disease. Here, we comprehensively characterize the effect of AR blockade on prostate cancer metabolism using transcriptomics, metabolomics and bioenergetics approaches. The metabolic response to AR inhibition is defined by reduced glycolysis, robust elongation of mitochondria, and increased reliance on mitochondrial oxidative metabolism. We establish DRP1 activity and MYC signaling as mediators of AR blockade-induced metabolic phenotypes. Rescuing DRP1 phosphorylation after AR inhibition restores mitochondrial fission, while rescuing MYC restores glycolytic activity and prevents sensitivity to complex I inhibition. Our study provides new insight into the regulation of treatment-induced metabolic phenotypes and vulnerabilities in prostate cancer.","INSTITUTE":"UCLA","LABORATORY":"Goldstein Lab","LAST_NAME":"Giafaglione","FIRST_NAME":"Jenna","ADDRESS":"610 Charles E Young Dr S, Los Angeles, CA, 90024, USA","EMAIL":"jgiafaglione@g.ucla.edu","PHONE":"408-728-3065"},

"STUDY":{"STUDY_TITLE":"Validation of on-target effect of IACS-010759 in vehicle- and Enzalutamide-treated 16D cells","STUDY_SUMMARY":"In this study, we sought to validate that 30nM IACS-010759, a complex I inhibitor, had an on-target effect in vehicle- and Enzalutamide-treated 16D prostate cancer cells.","INSTITUTE":"UCLA","LABORATORY":"Goldstein Lab","LAST_NAME":"Giafaglione","FIRST_NAME":"Jenna","ADDRESS":"610 Charles E Young Dr S, Los Angeles, CA, 90024, USA","EMAIL":"jgiafaglione@g.ucla.edu","PHONE":"408-728-3065"},

"SUBJECT":{"SUBJECT_TYPE":"Cultured cells","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"Naive-NT1",
"Factors":{"Treatment":"Vehicle (DMSO)"},
"Additional sample data":{"RAW_FILE_NAME":"Naive-NT1"}
},
{
"Subject ID":"-",
"Sample ID":"Naive-NT2",
"Factors":{"Treatment":"Vehicle (DMSO)"},
"Additional sample data":{"RAW_FILE_NAME":"Naive-NT2"}
},
{
"Subject ID":"-",
"Sample ID":"Naive-NT3",
"Factors":{"Treatment":"Vehicle (DMSO)"},
"Additional sample data":{"RAW_FILE_NAME":"Naive-NT3"}
},
{
"Subject ID":"-",
"Sample ID":"Naive-IACS-1",
"Factors":{"Treatment":"30nM IACS-010759"},
"Additional sample data":{"RAW_FILE_NAME":"Naive-IACS-1"}
},
{
"Subject ID":"-",
"Sample ID":"Naive-IACS-2",
"Factors":{"Treatment":"30nM IACS-010759"},
"Additional sample data":{"RAW_FILE_NAME":"Naive-IACS-2"}
},
{
"Subject ID":"-",
"Sample ID":"Naive-IACS-3",
"Factors":{"Treatment":"30nM IACS-010759"},
"Additional sample data":{"RAW_FILE_NAME":"Naive-IACS-3"}
},
{
"Subject ID":"-",
"Sample ID":"LT Enza-NT1",
"Factors":{"Treatment":"Vehicle (DMSO)"},
"Additional sample data":{"RAW_FILE_NAME":"LT Enza-NT1"}
},
{
"Subject ID":"-",
"Sample ID":"LT Enza-NT2",
"Factors":{"Treatment":"Vehicle (DMSO)"},
"Additional sample data":{"RAW_FILE_NAME":"LT Enza-NT2"}
},
{
"Subject ID":"-",
"Sample ID":"LT Enza-NT3",
"Factors":{"Treatment":"Vehicle (DMSO)"},
"Additional sample data":{"RAW_FILE_NAME":"LT Enza-NT3"}
},
{
"Subject ID":"-",
"Sample ID":"LT Enza-IACS-1",
"Factors":{"Treatment":"30nM IACS-010759"},
"Additional sample data":{"RAW_FILE_NAME":"LT Enza-IACS-1"}
},
{
"Subject ID":"-",
"Sample ID":"LT Enza-IACS-2",
"Factors":{"Treatment":"30nM IACS-010759"},
"Additional sample data":{"RAW_FILE_NAME":"LT Enza-IACS-2"}
},
{
"Subject ID":"-",
"Sample ID":"LT Enza-IACS-3",
"Factors":{"Treatment":"30nM IACS-010759"},
"Additional sample data":{"RAW_FILE_NAME":"LT Enza-IACS-3"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"Vehicle- and Enzalutamide-treated 16D cells were cultured with 30nM IACS-010759 for 24 hours","SAMPLE_TYPE":"Cultured cells"},

"TREATMENT":{"TREATMENT_SUMMARY":"Vehicle- and Enzalutamide-treated 16D cells were cultured with 30nM IACS-010759 in U13C-glucose-containing media for 24 hours"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"Cell plates were placed on ice and quickly washed with ice-cold 0.9% (w/v) NaCl. Cells were immediately treated with 500 μL of ice-cold MeOH and 200 μL water containing 1 μg of the internal standard norvaline. Cells were then scraped and placed in 1.5 mL centrifuge tubes kept on ice. Next, 500 μL of chloroform was added, after which samples were vortexed for 1 minute and then spun at 10,000g for 5 minutes at 4C. The aqueous layer was transferred to a GC/MS sample vial and dried overnight using a refrigerated CentriVap."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_TYPE":"GC","INSTRUMENT_NAME":"Agilent 7890A","COLUMN_NAME":"Agilent DB5-MS (30m x 0.25mm, 0.25um)","SOLVENT_A":"N/A (GC-MS)","SOLVENT_B":"N/A (GC-MS)","FLOW_GRADIENT":"N/A (GC-MS)","FLOW_RATE":"1 ml/min","COLUMN_TEMPERATURE":"23"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 5977B","INSTRUMENT_TYPE":"GC-TOF","MS_TYPE":"EI","ION_MODE":"POSITIVE","MS_COMMENTS":"Data was analyzed using Agilent MassHunter software. Stable isotope tracing data was corrected for natural abundance of heavy isotopes with FluxFix software using a reference set of unlabeled metabolite standards2."},

"MS_METABOLITE_DATA":{
"Units":"abundance",

"Data":[{"Metabolite":"a-Ketoglutarate(M0)","LT Enza-IACS-1":"99792","LT Enza-IACS-2":"106227","LT Enza-IACS-3":"27397","LT Enza-NT1":"16501","LT Enza-NT2":"45395","LT Enza-NT3":"15677","Naive-IACS-1":"109019","Naive-IACS-2":"163257","Naive-IACS-3":"236113","Naive-NT1":"57764","Naive-NT2":"65165","Naive-NT3":"55183"},{"Metabolite":"a-Ketoglutarate(M1)","LT Enza-IACS-1":"27012","LT Enza-IACS-2":"29811","LT Enza-IACS-3":"7399","LT Enza-NT1":"6334","LT Enza-NT2":"17293","LT Enza-NT3":"6327","Naive-IACS-1":"28521","Naive-IACS-2":"42532","Naive-IACS-3":"62072","Naive-NT1":"18109","Naive-NT2":"20578","Naive-NT3":"17510"},{"Metabolite":"a-Ketoglutarate(M2)","LT Enza-IACS-1":"17391","LT Enza-IACS-2":"17326","LT Enza-IACS-3":"4525","LT Enza-NT1":"7450","LT Enza-NT2":"20759","LT Enza-NT3":"7297","Naive-IACS-1":"14758","Naive-IACS-2":"21905","Naive-IACS-3":"31372","Naive-NT1":"23562","Naive-NT2":"26476","Naive-NT3":"22126"},{"Metabolite":"a-Ketoglutarate(M3)","LT Enza-IACS-1":"5004","LT Enza-IACS-2":"4888","LT Enza-IACS-3":"1290","LT Enza-NT1":"2885","LT Enza-NT2":"8369","LT Enza-NT3":"2925","Naive-IACS-1":"3355","Naive-IACS-2":"4886","Naive-IACS-3":"7049","Naive-NT1":"8694","Naive-NT2":"10250","Naive-NT3":"8141"},{"Metabolite":"a-Ketoglutarate(M4)","LT Enza-IACS-1":"2280","LT Enza-IACS-2":"2057","LT Enza-IACS-3":"468","LT Enza-NT1":"1504","LT Enza-NT2":"4474","LT Enza-NT3":"1572","Naive-IACS-1":"1149","Naive-IACS-2":"1792","Naive-IACS-3":"2942","Naive-NT1":"5683","Naive-NT2":"6280","Naive-NT3":"4911"},{"Metabolite":"a-Ketoglutarate(M5)","LT Enza-IACS-1":"887","LT Enza-IACS-2":"497","LT Enza-IACS-3":"236","LT Enza-NT1":"584","LT Enza-NT2":"1720","LT Enza-NT3":"531","Naive-IACS-1":"480","Naive-IACS-2":"623","Naive-IACS-3":"824","Naive-NT1":"2195","Naive-NT2":"2485","Naive-NT3":"2036"},{"Metabolite":"a-Ketoglutarate(M6)","LT Enza-IACS-1":"2260","LT Enza-IACS-2":"206","LT Enza-IACS-3":"158","LT Enza-NT1":"197","LT Enza-NT2":"1586","LT Enza-NT3":"356","Naive-IACS-1":"139","Naive-IACS-2":"144","Naive-IACS-3":"229","Naive-NT1":"649","Naive-NT2":"678","Naive-NT3":"651"},{"Metabolite":"Alanine260(M0)","LT Enza-IACS-1":"347992","LT Enza-IACS-2":"304246","LT Enza-IACS-3":"127124","LT Enza-NT1":"215690","LT Enza-NT2":"493745","LT Enza-NT3":"300897","Naive-IACS-1":"190886","Naive-IACS-2":"248095","Naive-IACS-3":"344244","Naive-NT1":"474138","Naive-NT2":"543040","Naive-NT3":"475509"},{"Metabolite":"Alanine260(M1)","LT Enza-IACS-1":"84950","LT Enza-IACS-2":"74185","LT Enza-IACS-3":"31090","LT Enza-NT1":"52690","LT Enza-NT2":"120919","LT Enza-NT3":"73435","Naive-IACS-1":"46972","Naive-IACS-2":"61016","Naive-IACS-3":"84438","Naive-NT1":"120178","Naive-NT2":"136954","Naive-NT3":"119851"},{"Metabolite":"Alanine260(M2)","LT Enza-IACS-1":"50668","LT Enza-IACS-2":"47518","LT Enza-IACS-3":"19364","LT Enza-NT1":"26996","LT Enza-NT2":"62778","LT Enza-NT3":"37530","Naive-IACS-1":"30655","Naive-IACS-2":"38658","Naive-IACS-3":"52604","Naive-NT1":"71447","Naive-NT2":"80192","Naive-NT3":"70174"},{"Metabolite":"Alanine260(M3)","LT Enza-IACS-1":"414036","LT Enza-IACS-2":"409583","LT Enza-IACS-3":"176339","LT Enza-NT1":"107178","LT Enza-NT2":"249742","LT Enza-NT3":"150091","Naive-IACS-1":"279888","Naive-IACS-2":"368704","Naive-IACS-3":"504625","Naive-NT1":"474792","Naive-NT2":"546152","Naive-NT3":"460254"},{"Metabolite":"Alanine260(M4)","LT Enza-IACS-1":"81616","LT Enza-IACS-2":"80654","LT Enza-IACS-3":"34541","LT Enza-NT1":"20783","LT Enza-NT2":"48753","LT Enza-NT3":"29305","Naive-IACS-1":"55029","Naive-IACS-2":"72583","Naive-IACS-3":"99197","Naive-NT1":"93635","Naive-NT2":"108125","Naive-NT3":"91382"},{"Metabolite":"Asparagine(M0)","LT Enza-IACS-1":"1009566","LT Enza-IACS-2":"895924","LT Enza-IACS-3":"239743","LT Enza-NT1":"277551","LT Enza-NT2":"846800","LT Enza-NT3":"472191","Naive-IACS-1":"596242","Naive-IACS-2":"824483","Naive-IACS-3":"1141523","Naive-NT1":"770563","Naive-NT2":"904853","Naive-NT3":"735327"},{"Metabolite":"Asparagine(M1)","LT Enza-IACS-1":"378186","LT Enza-IACS-2":"333547","LT Enza-IACS-3":"86528","LT Enza-NT1":"101076","LT Enza-NT2":"316461","LT Enza-NT3":"174011","Naive-IACS-1":"219235","Naive-IACS-2":"306109","Naive-IACS-3":"427761","Naive-NT1":"285676","Naive-NT2":"337770","Naive-NT3":"272437"},{"Metabolite":"Asparagine(M2)","LT Enza-IACS-1":"177273","LT Enza-IACS-2":"155219","LT Enza-IACS-3":"39939","LT Enza-NT1":"47764","LT Enza-NT2":"149812","LT Enza-NT3":"82321","Naive-IACS-1":"101807","Naive-IACS-2":"141772","Naive-IACS-3":"199196","Naive-NT1":"134608","Naive-NT2":"158848","Naive-NT3":"128790"},{"Metabolite":"Asparagine(M3)","LT Enza-IACS-1":"44832","LT Enza-IACS-2":"39529","LT Enza-IACS-3":"10173","LT Enza-NT1":"11725","LT Enza-NT2":"36870","LT Enza-NT3":"19857","Naive-IACS-1":"25054","Naive-IACS-2":"35035","Naive-IACS-3":"48983","Naive-NT1":"32799","Naive-NT2":"38387","Naive-NT3":"31336"},{"Metabolite":"Asparagine(M4)","LT Enza-IACS-1":"10765","LT Enza-IACS-2":"9469","LT Enza-IACS-3":"2490","LT Enza-NT1":"2766","LT Enza-NT2":"9068","LT Enza-NT3":"4966","Naive-IACS-1":"6114","Naive-IACS-2":"8415","Naive-IACS-3":"11697","Naive-NT1":"7816","Naive-NT2":"9151","Naive-NT3":"7411"},{"Metabolite":"Asparagine(M5)","LT Enza-IACS-1":"2090","LT Enza-IACS-2":"1915","LT Enza-IACS-3":"525","LT Enza-NT1":"562","LT Enza-NT2":"1958","LT Enza-NT3":"918","Naive-IACS-1":"1137","Naive-IACS-2":"1494","Naive-IACS-3":"2091","Naive-NT1":"1446","Naive-NT2":"1728","Naive-NT3":"1541"},{"Metabolite":"Aspartate418(M0)","LT Enza-IACS-1":"195550","LT Enza-IACS-2":"197609","LT Enza-IACS-3":"48245","LT Enza-NT1":"82575","LT Enza-NT2":"237275","LT Enza-NT3":"143991","Naive-IACS-1":"64890","Naive-IACS-2":"87671","Naive-IACS-3":"134395","Naive-NT1":"232148","Naive-NT2":"261238","Naive-NT3":"210047"},{"Metabolite":"Aspartate418(M1)","LT Enza-IACS-1":"71574","LT Enza-IACS-2":"70933","LT Enza-IACS-3":"16735","LT Enza-NT1":"35205","LT Enza-NT2":"102818","LT Enza-NT3":"61929","Naive-IACS-1":"23208","Naive-IACS-2":"31407","Naive-IACS-3":"47498","Naive-NT1":"97421","Naive-NT2":"109980","Naive-NT3":"88244"},{"Metabolite":"Aspartate418(M2)","LT Enza-IACS-1":"40702","LT Enza-IACS-2":"36894","LT Enza-IACS-3":"8752","LT Enza-NT1":"25167","LT Enza-NT2":"73247","LT Enza-NT3":"43587","Naive-IACS-1":"12642","Naive-IACS-2":"15910","Naive-IACS-3":"24828","Naive-NT1":"82784","Naive-NT2":"94530","Naive-NT3":"75720"},{"Metabolite":"Aspartate418(M3)","LT Enza-IACS-1":"25728","LT Enza-IACS-2":"30826","LT Enza-IACS-3":"6797","LT Enza-NT1":"11771","LT Enza-NT2":"34148","LT Enza-NT3":"20208","Naive-IACS-1":"10268","Naive-IACS-2":"12245","Naive-IACS-3":"18548","Naive-NT1":"47855","Naive-NT2":"53815","Naive-NT3":"42252"},{"Metabolite":"Aspartate418(M4)","LT Enza-IACS-1":"8355","LT Enza-IACS-2":"9605","LT Enza-IACS-3":"2104","LT Enza-NT1":"4414","LT Enza-NT2":"12837","LT Enza-NT3":"7599","Naive-IACS-1":"3250","Naive-IACS-2":"3873","Naive-IACS-3":"5863","Naive-NT1":"19736","Naive-NT2":"22345","Naive-NT3":"17571"},{"Metabolite":"Aspartate418(M5)","LT Enza-IACS-1":"2994","LT Enza-IACS-2":"3760","LT Enza-IACS-3":"778","LT Enza-NT1":"1371","LT Enza-NT2":"3891","LT Enza-NT3":"2330","Naive-IACS-1":"1376","Naive-IACS-2":"1517","Naive-IACS-3":"2254","Naive-NT1":"6330","Naive-NT2":"7250","Naive-NT3":"5684"},{"Metabolite":"Citrate459(M0)","LT Enza-IACS-1":"259696","LT Enza-IACS-2":"194777","LT Enza-IACS-3":"33887","LT Enza-NT1":"199299","LT Enza-NT2":"522614","LT Enza-NT3":"341684","Naive-IACS-1":"98254","Naive-IACS-2":"132349","Naive-IACS-3":"192898","Naive-NT1":"505142","Naive-NT2":"535640","Naive-NT3":"449210"},{"Metabolite":"Citrate459(M1)","LT Enza-IACS-1":"108572","LT Enza-IACS-2":"74133","LT Enza-IACS-3":"12946","LT Enza-NT1":"97653","LT Enza-NT2":"261469","LT Enza-NT3":"170281","Naive-IACS-1":"39001","Naive-IACS-2":"50164","Naive-IACS-3":"74062","Naive-NT1":"236628","Naive-NT2":"250774","Naive-NT3":"208074"},{"Metabolite":"Citrate459(M2)","LT Enza-IACS-1":"114201","LT Enza-IACS-2":"55734","LT Enza-IACS-3":"8366","LT Enza-NT1":"124291","LT Enza-NT2":"336339","LT Enza-NT3":"219868","Naive-IACS-1":"38206","Naive-IACS-2":"40431","Naive-IACS-3":"59647","Naive-NT1":"467196","Naive-NT2":"497097","Naive-NT3":"405808"},{"Metabolite":"Citrate459(M3)","LT Enza-IACS-1":"50502","LT Enza-IACS-2":"22718","LT Enza-IACS-3":"3402","LT Enza-NT1":"60302","LT Enza-NT2":"166903","LT Enza-NT3":"107257","Naive-IACS-1":"16912","Naive-IACS-2":"17148","Naive-IACS-3":"25433","Naive-NT1":"225645","Naive-NT2":"239952","Naive-NT3":"194992"},{"Metabolite":"Citrate459(M4)","LT Enza-IACS-1":"27676","LT Enza-IACS-2":"10173","LT Enza-IACS-3":"1488","LT Enza-NT1":"35105","LT Enza-NT2":"96256","LT Enza-NT3":"62456","Naive-IACS-1":"9020","Naive-IACS-2":"8256","Naive-IACS-3":"11972","Naive-NT1":"162560","Naive-NT2":"173046","Naive-NT3":"138143"},{"Metabolite":"Citrate459(M5)","LT Enza-IACS-1":"12763","LT Enza-IACS-2":"4783","LT Enza-IACS-3":"732","LT Enza-NT1":"14958","LT Enza-NT2":"42257","LT Enza-NT3":"27081","Naive-IACS-1":"4452","Naive-IACS-2":"4149","Naive-IACS-3":"5898","Naive-NT1":"82315","Naive-NT2":"87262","Naive-NT3":"68759"},{"Metabolite":"Citrate459(M6)","LT Enza-IACS-1":"4683","LT Enza-IACS-2":"1913","LT Enza-IACS-3":"276","LT Enza-NT1":"5408","LT Enza-NT2":"15157","LT Enza-NT3":"9903","Naive-IACS-1":"1892","Naive-IACS-2":"1635","Naive-IACS-3":"2177","Naive-NT1":"33007","Naive-NT2":"34714","Naive-NT3":"26838"},{"Metabolite":"Citrate459(M7)","LT Enza-IACS-1":"1729","LT Enza-IACS-2":"1276","LT Enza-IACS-3":"632","LT Enza-NT1":"2255","LT Enza-NT2":"5044","LT Enza-NT3":"3333","Naive-IACS-1":"1077","Naive-IACS-2":"1170","Naive-IACS-3":"1596","Naive-NT1":"10841","Naive-NT2":"11417","Naive-NT3":"9104"},{"Metabolite":"Citrate591(M0)","LT Enza-IACS-1":"48875","LT Enza-IACS-2":"35782","LT Enza-IACS-3":"6401","LT Enza-NT1":"36480","LT Enza-NT2":"99889","LT Enza-NT3":"63921","Naive-IACS-1":"17832","Naive-IACS-2":"24072","Naive-IACS-3":"34804","Naive-NT1":"96233","Naive-NT2":"101381","Naive-NT3":"84538"},{"Metabolite":"Citrate591(M1)","LT Enza-IACS-1":"25641","LT Enza-IACS-2":"17953","LT Enza-IACS-3":"3176","LT Enza-NT1":"21972","LT Enza-NT2":"59866","LT Enza-NT3":"38570","Naive-IACS-1":"9204","Naive-IACS-2":"12002","Naive-IACS-3":"17868","Naive-NT1":"55266","Naive-NT2":"58304","Naive-NT3":"47913"},{"Metabolite":"Citrate591(M2)","LT Enza-IACS-1":"24604","LT Enza-IACS-2":"12854","LT Enza-IACS-3":"2187","LT Enza-NT1":"25551","LT Enza-NT2":"71079","LT Enza-NT3":"45349","Naive-IACS-1":"8414","Naive-IACS-2":"9053","Naive-IACS-3":"13530","Naive-NT1":"93010","Naive-NT2":"99326","Naive-NT3":"80898"},{"Metabolite":"Citrate591(M3)","LT Enza-IACS-1":"12295","LT Enza-IACS-2":"5536","LT Enza-IACS-3":"776","LT Enza-NT1":"14148","LT Enza-NT2":"38540","LT Enza-NT3":"24966","Naive-IACS-1":"4140","Naive-IACS-2":"4081","Naive-IACS-3":"6400","Naive-NT1":"50983","Naive-NT2":"55183","Naive-NT3":"44282"},{"Metabolite":"Citrate591(M4)","LT Enza-IACS-1":"6647","LT Enza-IACS-2":"2662","LT Enza-IACS-3":"358","LT Enza-NT1":"8080","LT Enza-NT2":"22688","LT Enza-NT3":"14291","Naive-IACS-1":"2295","Naive-IACS-2":"2009","Naive-IACS-3":"2985","Naive-NT1":"35429","Naive-NT2":"38247","Naive-NT3":"30190"},{"Metabolite":"Citrate591(M5)","LT Enza-IACS-1":"3122","LT Enza-IACS-2":"1102","LT Enza-IACS-3":"212","LT Enza-NT1":"3644","LT Enza-NT2":"10424","LT Enza-NT3":"6623","Naive-IACS-1":"1052","Naive-IACS-2":"1026","Naive-IACS-3":"1436","Naive-NT1":"18881","Naive-NT2":"19719","Naive-NT3":"15869"},{"Metabolite":"Citrate591(M6)","LT Enza-IACS-1":"1251","LT Enza-IACS-2":"414","LT Enza-IACS-3":"78","LT Enza-NT1":"1375","LT Enza-NT2":"3924","LT Enza-NT3":"2646","Naive-IACS-1":"437","Naive-IACS-2":"368","Naive-IACS-3":"518","Naive-NT1":"8188","Naive-NT2":"8632","Naive-NT3":"6775"},{"Metabolite":"Citrate591(M7)","LT Enza-IACS-1":"429","LT Enza-IACS-2":"171","LT Enza-IACS-3":"18","LT Enza-NT1":"549","LT Enza-NT2":"1363","LT Enza-NT3":"893","Naive-IACS-1":"172","Naive-IACS-2":"142","Naive-IACS-3":"190","Naive-NT1":"2901","Naive-NT2":"3055","Naive-NT3":"2409"},{"Metabolite":"Cysteine(M0)","LT Enza-IACS-1":"23428","LT Enza-IACS-2":"25676","LT Enza-IACS-3":"1385","LT Enza-NT1":"1318","LT Enza-NT2":"6895","LT Enza-NT3":"1373","Naive-IACS-1":"6104","Naive-IACS-2":"27600","Naive-IACS-3":"28239","Naive-NT1":"3847","Naive-NT2":"6472","Naive-NT3":"7644"},{"Metabolite":"Cysteine(M1)","LT Enza-IACS-1":"8038","LT Enza-IACS-2":"8917","LT Enza-IACS-3":"477","LT Enza-NT1":"519","LT Enza-NT2":"2345","LT Enza-NT3":"455","Naive-IACS-1":"2143","Naive-IACS-2":"9831","Naive-IACS-3":"9880","Naive-NT1":"1245","Naive-NT2":"2004","Naive-NT3":"2558"},{"Metabolite":"Cysteine(M2)","LT Enza-IACS-1":"4830","LT Enza-IACS-2":"5118","LT Enza-IACS-3":"282","LT Enza-NT1":"176","LT Enza-NT2":"1385","LT Enza-NT3":"197","Naive-IACS-1":"1175","Naive-IACS-2":"5726","Naive-IACS-3":"5773","Naive-NT1":"746","Naive-NT2":"1204","Naive-NT3":"1487"},{"Metabolite":"Cysteine(M3)","LT Enza-IACS-1":"1628","LT Enza-IACS-2":"1378","LT Enza-IACS-3":"157","LT Enza-NT1":"115","LT Enza-NT2":"611","LT Enza-NT3":"164","Naive-IACS-1":"316","Naive-IACS-2":"1565","Naive-IACS-3":"1649","Naive-NT1":"217","Naive-NT2":"461","Naive-NT3":"620"},{"Metabolite":"Cysteine(M4)","LT Enza-IACS-1":"492","LT Enza-IACS-2":"426","LT Enza-IACS-3":"34","LT Enza-NT1":"52","LT Enza-NT2":"328","LT Enza-NT3":"41","Naive-IACS-1":"42","Naive-IACS-2":"434","Naive-IACS-3":"538","Naive-NT1":"107","Naive-NT2":"102","Naive-NT3":"220"},{"Metabolite":"Fumarate(M0)","LT Enza-IACS-1":"297423","LT Enza-IACS-2":"345604","LT Enza-IACS-3":"120547","LT Enza-NT1":"45649","LT Enza-NT2":"105267","LT Enza-NT3":"64798","Naive-IACS-1":"203366","Naive-IACS-2":"282960","Naive-IACS-3":"384063","Naive-NT1":"182440","Naive-NT2":"208741","Naive-NT3":"172595"},{"Metabolite":"Fumarate(M1)","LT Enza-IACS-1":"73693","LT Enza-IACS-2":"84908","LT Enza-IACS-3":"30144","LT Enza-NT1":"15047","LT Enza-NT2":"35614","LT Enza-NT3":"21806","Naive-IACS-1":"50078","Naive-IACS-2":"69196","Naive-IACS-3":"94011","Naive-NT1":"55822","Naive-NT2":"64273","Naive-NT3":"52640"},{"Metabolite":"Fumarate(M2)","LT Enza-IACS-1":"43235","LT Enza-IACS-2":"46509","LT Enza-IACS-3":"16624","LT Enza-NT1":"12057","LT Enza-NT2":"29714","LT Enza-NT3":"18096","Naive-IACS-1":"26973","Naive-IACS-2":"36790","Naive-IACS-3":"50178","Naive-NT1":"55348","Naive-NT2":"63541","Naive-NT3":"50658"},{"Metabolite":"Fumarate(M3)","LT Enza-IACS-1":"58852","LT Enza-IACS-2":"60773","LT Enza-IACS-3":"23936","LT Enza-NT1":"5025","LT Enza-NT2":"13648","LT Enza-NT3":"8100","Naive-IACS-1":"39397","Naive-IACS-2":"56524","Naive-IACS-3":"75943","Naive-NT1":"29420","Naive-NT2":"33113","Naive-NT3":"26731"},{"Metabolite":"Fumarate(M4)","LT Enza-IACS-1":"15426","LT Enza-IACS-2":"21060","LT Enza-IACS-3":"7391","LT Enza-NT1":"2974","LT Enza-NT2":"7867","LT Enza-NT3":"5085","Naive-IACS-1":"11059","Naive-IACS-2":"13904","Naive-IACS-3":"19153","Naive-NT1":"13414","Naive-NT2":"14313","Naive-NT3":"11549"},{"Metabolite":"Fumarate(M5)","LT Enza-IACS-1":"5292","LT Enza-IACS-2":"7258","LT Enza-IACS-3":"2435","LT Enza-NT1":"627","LT Enza-NT2":"1462","LT Enza-NT3":"1062","Naive-IACS-1":"3801","Naive-IACS-2":"4966","Naive-IACS-3":"7090","Naive-NT1":"3167","Naive-NT2":"3548","Naive-NT3":"2610"},{"Metabolite":"GABA(M0)","LT Enza-IACS-1":"27975","LT Enza-IACS-2":"29870","LT Enza-IACS-3":"7247","LT Enza-NT1":"3731","LT Enza-NT2":"15089","LT Enza-NT3":"7153","Naive-IACS-1":"17984","Naive-IACS-2":"25165","Naive-IACS-3":"40459","Naive-NT1":"8093","Naive-NT2":"17940","Naive-NT3":"13949"},{"Metabolite":"GABA(M1)","LT Enza-IACS-1":"6219","LT Enza-IACS-2":"5876","LT Enza-IACS-3":"1501","LT Enza-NT1":"649","LT Enza-NT2":"3228","LT Enza-NT3":"1440","Naive-IACS-1":"3872","Naive-IACS-2":"5669","Naive-IACS-3":"8598","Naive-NT1":"1727","Naive-NT2":"3997","Naive-NT3":"2999"},{"Metabolite":"GABA(M2)","LT Enza-IACS-1":"2640","LT Enza-IACS-2":"2933","LT Enza-IACS-3":"593","LT Enza-NT1":"262","LT Enza-NT2":"1498","LT Enza-NT3":"566","Naive-IACS-1":"1846","Naive-IACS-2":"2531","Naive-IACS-3":"3701","Naive-NT1":"705","Naive-NT2":"1453","Naive-NT3":"1362"},{"Metabolite":"GABA(M3)","LT Enza-IACS-1":"732","LT Enza-IACS-2":"1124","LT Enza-IACS-3":"376","LT Enza-NT1":"1855","LT Enza-NT2":"474","LT Enza-NT3":"2344","Naive-IACS-1":"2573","Naive-IACS-2":"2328","Naive-IACS-3":"2299","Naive-NT1":"491","Naive-NT2":"515","Naive-NT3":"377"},{"Metabolite":"GABA(M4)","LT Enza-IACS-1":"273","LT Enza-IACS-2":"411","LT Enza-IACS-3":"155","LT Enza-NT1":"277","LT Enza-NT2":"374","LT Enza-NT3":"298","Naive-IACS-1":"933","Naive-IACS-2":"1225","Naive-IACS-3":"1032","Naive-NT1":"318","Naive-NT2":"264","Naive-NT3":"559"},{"Metabolite":"GABA(M5)","LT Enza-IACS-1":"131","LT Enza-IACS-2":"138","LT Enza-IACS-3":"429","LT Enza-NT1":"188","LT Enza-NT2":"205","LT Enza-NT3":"447","Naive-IACS-1":"332","Naive-IACS-2":"184","Naive-IACS-3":"156","Naive-NT1":"498","Naive-NT2":"41","Naive-NT3":"115"},{"Metabolite":"Glutamate432(M0)","LT Enza-IACS-1":"2147649","LT Enza-IACS-2":"2202498","LT Enza-IACS-3":"718099","LT Enza-NT1":"886558","LT Enza-NT2":"2273429","LT Enza-NT3":"1382455","Naive-IACS-1":"1288339","Naive-IACS-2":"1719802","Naive-IACS-3":"2362496","Naive-NT1":"1588360","Naive-NT2":"1822097","Naive-NT3":"1531879"},{"Metabolite":"Glutamate432(M1)","LT Enza-IACS-1":"852865","LT Enza-IACS-2":"848532","LT Enza-IACS-3":"266843","LT Enza-NT1":"438353","LT Enza-NT2":"1149927","LT Enza-NT3":"692062","Naive-IACS-1":"488485","Naive-IACS-2":"652815","Naive-IACS-3":"905766","Naive-NT1":"684174","Naive-NT2":"790570","Naive-NT3":"658296"},{"Metabolite":"Glutamate432(M2)","LT Enza-IACS-1":"603646","LT Enza-IACS-2":"543616","LT Enza-IACS-3":"166578","LT Enza-NT1":"490676","LT Enza-NT2":"1308822","LT Enza-NT3":"786124","Naive-IACS-1":"283478","Naive-IACS-2":"362904","Naive-IACS-3":"505833","Naive-NT1":"801539","Naive-NT2":"924647","Naive-NT3":"759431"},{"Metabolite":"Glutamate432(M3)","LT Enza-IACS-1":"215559","LT Enza-IACS-2":"180541","LT Enza-IACS-3":"54028","LT Enza-NT1":"230336","LT Enza-NT2":"626680","LT Enza-NT3":"373980","Naive-IACS-1":"85226","Naive-IACS-2":"104504","Naive-IACS-3":"145835","Naive-NT1":"361911","Naive-NT2":"417552","Naive-NT3":"337641"},{"Metabolite":"Glutamate432(M4)","LT Enza-IACS-1":"96538","LT Enza-IACS-2":"74831","LT Enza-IACS-3":"21972","LT Enza-NT1":"122981","LT Enza-NT2":"338800","LT Enza-NT3":"201539","Naive-IACS-1":"33020","Naive-IACS-2":"37250","Naive-IACS-3":"51858","Naive-NT1":"220095","Naive-NT2":"253560","Naive-NT3":"201624"},{"Metabolite":"Glutamate432(M5)","LT Enza-IACS-1":"37146","LT Enza-IACS-2":"28896","LT Enza-IACS-3":"8683","LT Enza-NT1":"46541","LT Enza-NT2":"129374","LT Enza-NT3":"77408","Naive-IACS-1":"11295","Naive-IACS-2":"12184","Naive-IACS-3":"16707","Naive-NT1":"93089","Naive-NT2":"107918","Naive-NT3":"84420"},{"Metabolite":"Glutamate432(M6)","LT Enza-IACS-1":"10982","LT Enza-IACS-2":"8629","LT Enza-IACS-3":"2558","LT Enza-NT1":"14235","LT Enza-NT2":"39788","LT Enza-NT3":"23753","Naive-IACS-1":"3160","Naive-IACS-2":"3432","Naive-IACS-3":"4702","Naive-NT1":"29840","Naive-NT2":"34398","Naive-NT3":"27046"},{"Metabolite":"Isoleucine274(M0)","LT Enza-IACS-1":"161724","LT Enza-IACS-2":"166539","LT Enza-IACS-3":"52166","LT Enza-NT1":"51963","LT Enza-NT2":"153622","LT Enza-NT3":"128328","Naive-IACS-1":"100803","Naive-IACS-2":"134061","Naive-IACS-3":"210366","Naive-NT1":"124092","Naive-NT2":"169851","Naive-NT3":"121935"},{"Metabolite":"Isoleucine274(M1)","LT Enza-IACS-1":"42539","LT Enza-IACS-2":"43741","LT Enza-IACS-3":"13706","LT Enza-NT1":"12019","LT Enza-NT2":"40515","LT Enza-NT3":"33754","Naive-IACS-1":"26436","Naive-IACS-2":"34983","Naive-IACS-3":"55797","Naive-NT1":"32529","Naive-NT2":"44776","Naive-NT3":"32173"},{"Metabolite":"Isoleucine274(M2)","LT Enza-IACS-1":"15114","LT Enza-IACS-2":"16711","LT Enza-IACS-3":"5608","LT Enza-NT1":"4943","LT Enza-NT2":"15552","LT Enza-NT3":"12603","Naive-IACS-1":"9959","Naive-IACS-2":"13368","Naive-IACS-3":"21237","Naive-NT1":"12428","Naive-NT2":"17142","Naive-NT3":"11773"},{"Metabolite":"Isoleucine274(M3)","LT Enza-IACS-1":"2763","LT Enza-IACS-2":"2974","LT Enza-IACS-3":"870","LT Enza-NT1":"833","LT Enza-NT2":"2737","LT Enza-NT3":"2204","Naive-IACS-1":"1758","Naive-IACS-2":"2428","Naive-IACS-3":"3529","Naive-NT1":"2139","Naive-NT2":"2951","Naive-NT3":"1901"},{"Metabolite":"Isoleucine274(M4)","LT Enza-IACS-1":"705","LT Enza-IACS-2":"537","LT Enza-IACS-3":"933","LT Enza-NT1":"52","LT Enza-NT2":"1494","LT Enza-NT3":"860","Naive-IACS-1":"326","Naive-IACS-2":"513","Naive-IACS-3":"912","Naive-NT1":"435","Naive-NT2":"587","Naive-NT3":"454"},{"Metabolite":"Isoleucine274(M5)","LT Enza-IACS-1":"128","LT Enza-IACS-2":"74","LT Enza-IACS-3":"73","LT Enza-NT1":"","LT Enza-NT2":"188","LT Enza-NT3":"97","Naive-IACS-1":"166","Naive-IACS-2":"144","Naive-IACS-3":"148","Naive-NT1":"89","Naive-NT2":"57","Naive-NT3":"160"},{"Metabolite":"Isoleucine274(M6)","LT Enza-IACS-1":"122","LT Enza-IACS-2":"39","LT Enza-IACS-3":"39","LT Enza-NT1":"213","LT Enza-NT2":"60","LT Enza-NT3":"68","Naive-IACS-1":"35","Naive-IACS-2":"21","Naive-IACS-3":"37","Naive-NT1":"","Naive-NT2":"46","Naive-NT3":"26"},{"Metabolite":"Isoleucine274(M7)","LT Enza-IACS-1":"28","LT Enza-IACS-2":"","LT Enza-IACS-3":"47","LT Enza-NT1":"","LT Enza-NT2":"22","LT Enza-NT3":"","Naive-IACS-1":"","Naive-IACS-2":"323","Naive-IACS-3":"128","Naive-NT1":"1206","Naive-NT2":"","Naive-NT3":""},{"Metabolite":"Itaconate(M0)","LT Enza-IACS-1":"1244","LT Enza-IACS-2":"3973","LT Enza-IACS-3":"808","LT Enza-NT1":"11754","LT Enza-NT2":"1111","LT Enza-NT3":"964","Naive-IACS-1":"1150","Naive-IACS-2":"917","Naive-IACS-3":"1041","Naive-NT1":"1478","Naive-NT2":"1282","Naive-NT3":"648"},{"Metabolite":"Itaconate(M1)","LT Enza-IACS-1":"249","LT Enza-IACS-2":"1364","LT Enza-IACS-3":"3849","LT Enza-NT1":"3381","LT Enza-NT2":"5684","LT Enza-NT3":"4092","Naive-IACS-1":"4893","Naive-IACS-2":"4223","Naive-IACS-3":"5014","Naive-NT1":"5384","Naive-NT2":"282","Naive-NT3":"325"},{"Metabolite":"Itaconate(M2)","LT Enza-IACS-1":"5506","LT Enza-IACS-2":"3509","LT Enza-IACS-3":"4229","LT Enza-NT1":"4591","LT Enza-NT2":"4839","LT Enza-NT3":"4958","Naive-IACS-1":"3857","Naive-IACS-2":"4479","Naive-IACS-3":"5665","Naive-NT1":"656","Naive-NT2":"5076","Naive-NT3":"4099"},{"Metabolite":"Itaconate(M3)","LT Enza-IACS-1":"3504","LT Enza-IACS-2":"1893","LT Enza-IACS-3":"2269","LT Enza-NT1":"2328","LT Enza-NT2":"2392","LT Enza-NT3":"2393","Naive-IACS-1":"1292","Naive-IACS-2":"2255","Naive-IACS-3":"3132","Naive-NT1":"2189","Naive-NT2":"2161","Naive-NT3":"2469"},{"Metabolite":"Itaconate(M4)","LT Enza-IACS-1":"578929","LT Enza-IACS-2":"167230","LT Enza-IACS-3":"359099","LT Enza-NT1":"383383","LT Enza-NT2":"361021","LT Enza-NT3":"432142","Naive-IACS-1":"178991","Naive-IACS-2":"319433","Naive-IACS-3":"475830","Naive-NT1":"240941","Naive-NT2":"328553","Naive-NT3":"380785"},{"Metabolite":"Itaconate(M5)","LT Enza-IACS-1":"152438","LT Enza-IACS-2":"43195","LT Enza-IACS-3":"93278","LT Enza-NT1":"100113","LT Enza-NT2":"94321","LT Enza-NT3":"113133","Naive-IACS-1":"46409","Naive-IACS-2":"83437","Naive-IACS-3":"124146","Naive-NT1":"62380","Naive-NT2":"85585","Naive-NT3":"100581"},{"Metabolite":"Itaconate(M6)","LT Enza-IACS-1":"42121","LT Enza-IACS-2":"5066","LT Enza-IACS-3":"3474","LT Enza-NT1":"3764","LT Enza-NT2":"4542","LT Enza-NT3":"3050","Naive-IACS-1":"5282","Naive-IACS-2":"3861","Naive-IACS-3":"35245","Naive-NT1":"3923","Naive-NT2":"4230","Naive-NT3":"3968"},{"Metabolite":"KIC (M0)","LT Enza-IACS-1":"18686","LT Enza-IACS-2":"19489","LT Enza-IACS-3":"5533","LT Enza-NT1":"4787","LT Enza-NT2":"13926","LT Enza-NT3":"4635","Naive-IACS-1":"24363","Naive-IACS-2":"32599","Naive-IACS-3":"51708","Naive-NT1":"10221","Naive-NT2":"9742","Naive-NT3":"10955"},{"Metabolite":"KIC (M1)","LT Enza-IACS-1":"2659","LT Enza-IACS-2":"2965","LT Enza-IACS-3":"1004","LT Enza-NT1":"1056","LT Enza-NT2":"1792","LT Enza-NT3":"483","Naive-IACS-1":"3397","Naive-IACS-2":"4629","Naive-IACS-3":"8141","Naive-NT1":"1662","Naive-NT2":"1263","Naive-NT3":"1359"},{"Metabolite":"KIC (M2)","LT Enza-IACS-1":"893","LT Enza-IACS-2":"1309","LT Enza-IACS-3":"428","LT Enza-NT1":"293","LT Enza-NT2":"724","LT Enza-NT3":"328","Naive-IACS-1":"1125","Naive-IACS-2":"1538","Naive-IACS-3":"2753","Naive-NT1":"400","Naive-NT2":"661","Naive-NT3":"853"},{"Metabolite":"KIC (M3)","LT Enza-IACS-1":"1640","LT Enza-IACS-2":"1985","LT Enza-IACS-3":"104","LT Enza-NT1":"1403","LT Enza-NT2":"2086","LT Enza-NT3":"72","Naive-IACS-1":"1790","Naive-IACS-2":"105","Naive-IACS-3":"282","Naive-NT1":"75","Naive-NT2":"1431","Naive-NT3":"1566"},{"Metabolite":"KIC (M4)","LT Enza-IACS-1":"329","LT Enza-IACS-2":"23","LT Enza-IACS-3":"60","LT Enza-NT1":"40","LT Enza-NT2":"490","LT Enza-NT3":"11","Naive-IACS-1":"133","Naive-IACS-2":"463","Naive-IACS-3":"299","Naive-NT1":"255","Naive-NT2":"56","Naive-NT3":"362"},{"Metabolite":"KIC (M5)","LT Enza-IACS-1":"1131","LT Enza-IACS-2":"2051","LT Enza-IACS-3":"63","LT Enza-NT1":"622","LT Enza-NT2":"1244","LT Enza-NT3":"520","Naive-IACS-1":"2066","Naive-IACS-2":"831","Naive-IACS-3":"870","Naive-NT1":"1249","Naive-NT2":"1540","Naive-NT3":"807"},{"Metabolite":"KIC (M6)","LT Enza-IACS-1":"2355","LT Enza-IACS-2":"2720","LT Enza-IACS-3":"2372","LT Enza-NT1":"2360","LT Enza-NT2":"3208","LT Enza-NT3":"2018","Naive-IACS-1":"2119","Naive-IACS-2":"2127","Naive-IACS-3":"1794","Naive-NT1":"1812","Naive-NT2":"2011","Naive-NT3":"2182"},{"Metabolite":"KIC (M7)","LT Enza-IACS-1":"379","LT Enza-IACS-2":"79","LT Enza-IACS-3":"53","LT Enza-NT1":"63","LT Enza-NT2":"43","LT Enza-NT3":"409","Naive-IACS-1":"522","Naive-IACS-2":"435","Naive-IACS-3":"443","Naive-NT1":"73","Naive-NT2":"","Naive-NT3":"24"},{"Metabolite":"KIV (M0)","LT Enza-IACS-1":"807","LT Enza-IACS-2":"969","LT Enza-IACS-3":"614","LT Enza-NT1":"600","LT Enza-NT2":"589","LT Enza-NT3":"766","Naive-IACS-1":"907","Naive-IACS-2":"737","Naive-IACS-3":"1915","Naive-NT1":"493","Naive-NT2":"281","Naive-NT3":"925"},{"Metabolite":"KMV(M0)","LT Enza-IACS-1":"14310","LT Enza-IACS-2":"16931","LT Enza-IACS-3":"8918","LT Enza-NT1":"6320","LT Enza-NT2":"13204","LT Enza-NT3":"6124","Naive-IACS-1":"15747","Naive-IACS-2":"21836","Naive-IACS-3":"32382","Naive-NT1":"10312","Naive-NT2":"12261","Naive-NT3":"11733"},{"Metabolite":"Lactate261(M0)","LT Enza-IACS-1":"1196661","LT Enza-IACS-2":"971763","LT Enza-IACS-3":"439592","LT Enza-NT1":"331918","LT Enza-NT2":"1105297","LT Enza-NT3":"948370","Naive-IACS-1":"1097993","Naive-IACS-2":"1719796","Naive-IACS-3":"2143845","Naive-NT1":"793387","Naive-NT2":"800079","Naive-NT3":"611706"},{"Metabolite":"Lactate261(M1)","LT Enza-IACS-1":"277408","LT Enza-IACS-2":"224940","LT Enza-IACS-3":"100266","LT Enza-NT1":"79000","LT Enza-NT2":"257610","LT Enza-NT3":"218026","Naive-IACS-1":"254832","Naive-IACS-2":"398785","Naive-IACS-3":"501223","Naive-NT1":"189498","Naive-NT2":"190570","Naive-NT3":"147506"},{"Metabolite":"Lactate261(M2)","LT Enza-IACS-1":"174602","LT Enza-IACS-2":"157367","LT Enza-IACS-3":"66850","LT Enza-NT1":"41195","LT Enza-NT2":"124674","LT Enza-NT3":"105463","Naive-IACS-1":"192178","Naive-IACS-2":"277244","Naive-IACS-3":"362144","Naive-NT1":"120748","Naive-NT2":"123928","Naive-NT3":"101477"},{"Metabolite":"Lactate261(M3)","LT Enza-IACS-1":"1374233","LT Enza-IACS-2":"1461494","LT Enza-IACS-3":"618121","LT Enza-NT1":"146085","LT Enza-NT2":"274459","LT Enza-NT3":"152882","Naive-IACS-1":"2076662","Naive-IACS-2":"2765173","Naive-IACS-3":"3840234","Naive-NT1":"770592","Naive-NT2":"808819","Naive-NT3":"723843"},{"Metabolite":"Lactate261(M4)","LT Enza-IACS-1":"272848","LT Enza-IACS-2":"292006","LT Enza-IACS-3":"121707","LT Enza-NT1":"28625","LT Enza-NT2":"52385","LT Enza-NT3":"28345","Naive-IACS-1":"420230","Naive-IACS-2":"562633","Naive-IACS-3":"796239","Naive-NT1":"151918","Naive-NT2":"160304","Naive-NT3":"143161"},{"Metabolite":"Leucine 274 (M0)","LT Enza-IACS-1":"233755","LT Enza-IACS-2":"244519","LT Enza-IACS-3":"83763","LT Enza-NT1":"83814","LT Enza-NT2":"240761","LT Enza-NT3":"201785","Naive-IACS-1":"142420","Naive-IACS-2":"188062","Naive-IACS-3":"284248","Naive-NT1":"170784","Naive-NT2":"231946","Naive-NT3":"173355"},{"Metabolite":"Leucine 274 (M1)","LT Enza-IACS-1":"58850","LT Enza-IACS-2":"61438","LT Enza-IACS-3":"20620","LT Enza-NT1":"20735","LT Enza-NT2":"60338","LT Enza-NT3":"50592","Naive-IACS-1":"35086","Naive-IACS-2":"47371","Naive-IACS-3":"72048","Naive-NT1":"42724","Naive-NT2":"58289","Naive-NT3":"43668"},{"Metabolite":"Leucine 274 (M2)","LT Enza-IACS-1":"22889","LT Enza-IACS-2":"23498","LT Enza-IACS-3":"7866","LT Enza-NT1":"8068","LT Enza-NT2":"24561","LT Enza-NT3":"19536","Naive-IACS-1":"13738","Naive-IACS-2":"18050","Naive-IACS-3":"27428","Naive-NT1":"16913","Naive-NT2":"24238","Naive-NT3":"17414"},{"Metabolite":"Leucine 274 (M3)","LT Enza-IACS-1":"3720","LT Enza-IACS-2":"3889","LT Enza-IACS-3":"1336","LT Enza-NT1":"1346","LT Enza-NT2":"4164","LT Enza-NT3":"3187","Naive-IACS-1":"2214","Naive-IACS-2":"3014","Naive-IACS-3":"4646","Naive-NT1":"2772","Naive-NT2":"4167","Naive-NT3":"3053"},{"Metabolite":"Leucine 274 (M4)","LT Enza-IACS-1":"713","LT Enza-IACS-2":"535","LT Enza-IACS-3":"308","LT Enza-NT1":"190","LT Enza-NT2":"985","LT Enza-NT3":"495","Naive-IACS-1":"464","Naive-IACS-2":"977","Naive-IACS-3":"1239","Naive-NT1":"704","Naive-NT2":"1195","Naive-NT3":"496"},{"Metabolite":"Leucine 274 (M5)","LT Enza-IACS-1":"767","LT Enza-IACS-2":"493","LT Enza-IACS-3":"700","LT Enza-NT1":"344","LT Enza-NT2":"607","LT Enza-NT3":"787","Naive-IACS-1":"894","Naive-IACS-2":"453","Naive-IACS-3":"791","Naive-NT1":"654","Naive-NT2":"705","Naive-NT3":"580"},{"Metabolite":"Leucine 274 (M6)","LT Enza-IACS-1":"3285","LT Enza-IACS-2":"4357","LT Enza-IACS-3":"2755","LT Enza-NT1":"3047","LT Enza-NT2":"4567","LT Enza-NT3":"2600","Naive-IACS-1":"3601","Naive-IACS-2":"4186","Naive-IACS-3":"4598","Naive-NT1":"2878","Naive-NT2":"4335","Naive-NT3":"3553"},{"Metabolite":"Malate(M0)","LT Enza-IACS-1":"489598","LT Enza-IACS-2":"558136","LT Enza-IACS-3":"193726","LT Enza-NT1":"48496","LT Enza-NT2":"139821","LT Enza-NT3":"80332","Naive-IACS-1":"358903","Naive-IACS-2":"477570","Naive-IACS-3":"646897","Naive-NT1":"301571","Naive-NT2":"333139","Naive-NT3":"277949"},{"Metabolite":"Malate(M1)","LT Enza-IACS-1":"178287","LT Enza-IACS-2":"201971","LT Enza-IACS-3":"68283","LT Enza-NT1":"22731","LT Enza-NT2":"66644","LT Enza-NT3":"37905","Naive-IACS-1":"128550","Naive-IACS-2":"172170","Naive-IACS-3":"234019","Naive-NT1":"129174","Naive-NT2":"142516","Naive-NT3":"118226"},{"Metabolite":"Malate(M2)","LT Enza-IACS-1":"109575","LT Enza-IACS-2":"118055","LT Enza-IACS-3":"40435","LT Enza-NT1":"19785","LT Enza-NT2":"59139","LT Enza-NT3":"34512","Naive-IACS-1":"72826","Naive-IACS-2":"96926","Naive-IACS-3":"130322","Naive-NT1":"124378","Naive-NT2":"136184","Naive-NT3":"110903"},{"Metabolite":"Malate(M3)","LT Enza-IACS-1":"118795","LT Enza-IACS-2":"136116","LT Enza-IACS-3":"48078","LT Enza-NT1":"10193","LT Enza-NT2":"30694","LT Enza-NT3":"17611","Naive-IACS-1":"85973","Naive-IACS-2":"114705","Naive-IACS-3":"153074","Naive-NT1":"71447","Naive-NT2":"77712","Naive-NT3":"62736"},{"Metabolite":"Malate(M4)","LT Enza-IACS-1":"38174","LT Enza-IACS-2":"43348","LT Enza-IACS-3":"15218","LT Enza-NT1":"4125","LT Enza-NT2":"12591","LT Enza-NT3":"7061","Naive-IACS-1":"26740","Naive-IACS-2":"35958","Naive-IACS-3":"47579","Naive-NT1":"30705","Naive-NT2":"33435","Naive-NT3":"26641"},{"Metabolite":"Malate(M5)","LT Enza-IACS-1":"15753","LT Enza-IACS-2":"18288","LT Enza-IACS-3":"6520","LT Enza-NT1":"1304","LT Enza-NT2":"3936","LT Enza-NT3":"2267","Naive-IACS-1":"11468","Naive-IACS-2":"15250","Naive-IACS-3":"20152","Naive-NT1":"10110","Naive-NT2":"10969","Naive-NT3":"8664"},{"Metabolite":"Methionine320(M0)","LT Enza-IACS-1":"69564","LT Enza-IACS-2":"67708","LT Enza-IACS-3":"18714","LT Enza-NT1":"22342","LT Enza-NT2":"75146","LT Enza-NT3":"52193","Naive-IACS-1":"36913","Naive-IACS-2":"50339","Naive-IACS-3":"79600","Naive-NT1":"47115","Naive-NT2":"65481","Naive-NT3":"50128"},{"Metabolite":"Methionine320(M1)","LT Enza-IACS-1":"17792","LT Enza-IACS-2":"17477","LT Enza-IACS-3":"4799","LT Enza-NT1":"5883","LT Enza-NT2":"19560","LT Enza-NT3":"13551","Naive-IACS-1":"9649","Naive-IACS-2":"12943","Naive-IACS-3":"20731","Naive-NT1":"12345","Naive-NT2":"17000","Naive-NT3":"13009"},{"Metabolite":"Methionine320(M2)","LT Enza-IACS-1":"9981","LT Enza-IACS-2":"10309","LT Enza-IACS-3":"2750","LT Enza-NT1":"3334","LT Enza-NT2":"10771","LT Enza-NT3":"7598","Naive-IACS-1":"5469","Naive-IACS-2":"7259","Naive-IACS-3":"11512","Naive-NT1":"6826","Naive-NT2":"9441","Naive-NT3":"7170"},{"Metabolite":"Methionine320(M3)","LT Enza-IACS-1":"2155","LT Enza-IACS-2":"2244","LT Enza-IACS-3":"503","LT Enza-NT1":"668","LT Enza-NT2":"2230","LT Enza-NT3":"1586","Naive-IACS-1":"1244","Naive-IACS-2":"1483","Naive-IACS-3":"2514","Naive-NT1":"1450","Naive-NT2":"2103","Naive-NT3":"1494"},{"Metabolite":"Methionine320(M4)","LT Enza-IACS-1":"1050","LT Enza-IACS-2":"1036","LT Enza-IACS-3":"256","LT Enza-NT1":"387","LT Enza-NT2":"1268","LT Enza-NT3":"877","Naive-IACS-1":"891","Naive-IACS-2":"1197","Naive-IACS-3":"1866","Naive-NT1":"1236","Naive-NT2":"1843","Naive-NT3":"1321"},{"Metabolite":"Methionine320(M5)","LT Enza-IACS-1":"215","LT Enza-IACS-2":"196","LT Enza-IACS-3":"158","LT Enza-NT1":"314","LT Enza-NT2":"469","LT Enza-NT3":"377","Naive-IACS-1":"334","Naive-IACS-2":"332","Naive-IACS-3":"400","Naive-NT1":"389","Naive-NT2":"561","Naive-NT3":"377"},{"Metabolite":"Methionine320(M6)","LT Enza-IACS-1":"89","LT Enza-IACS-2":"70","LT Enza-IACS-3":"70","LT Enza-NT1":"34","LT Enza-NT2":"25","LT Enza-NT3":"103","Naive-IACS-1":"170","Naive-IACS-2":"169","Naive-IACS-3":"140","Naive-NT1":"162","Naive-NT2":"190","Naive-NT3":"144"},{"Metabolite":"N-AcetylAspartate(M0)","LT Enza-IACS-1":"1312318","LT Enza-IACS-2":"1465725","LT Enza-IACS-3":"469880","LT Enza-NT1":"698030","LT Enza-NT2":"1773597","LT Enza-NT3":"1104964","Naive-IACS-1":"203049","Naive-IACS-2":"270212","Naive-IACS-3":"388504","Naive-NT1":"579161","Naive-NT2":"628760","Naive-NT3":"510252"},{"Metabolite":"N-AcetylAspartate(M1)","LT Enza-IACS-1":"376624","LT Enza-IACS-2":"399676","LT Enza-IACS-3":"122563","LT Enza-NT1":"214055","LT Enza-NT2":"556580","LT Enza-NT3":"358112","Naive-IACS-1":"55119","Naive-IACS-2":"69533","Naive-IACS-3":"102612","Naive-NT1":"186297","Naive-NT2":"202245","Naive-NT3":"160899"},{"Metabolite":"N-AcetylAspartate(M2)","LT Enza-IACS-1":"227972","LT Enza-IACS-2":"223009","LT Enza-IACS-3":"60683","LT Enza-NT1":"178112","LT Enza-NT2":"461964","LT Enza-NT3":"291904","Naive-IACS-1":"44726","Naive-IACS-2":"48022","Naive-IACS-3":"74073","Naive-NT1":"282207","Naive-NT2":"292435","Naive-NT3":"231835"},{"Metabolite":"N-AcetylAspartate(M3)","LT Enza-IACS-1":"136234","LT Enza-IACS-2":"146987","LT Enza-IACS-3":"44002","LT Enza-NT1":"61750","LT Enza-NT2":"158462","LT Enza-NT3":"101326","Naive-IACS-1":"33844","Naive-IACS-2":"41876","Naive-IACS-3":"59157","Naive-NT1":"103187","Naive-NT2":"108891","Naive-NT3":"83151"},{"Metabolite":"N-AcetylAspartate(M4)","LT Enza-IACS-1":"36776","LT Enza-IACS-2":"36982","LT Enza-IACS-3":"10812","LT Enza-NT1":"28767","LT Enza-NT2":"73277","LT Enza-NT3":"47630","Naive-IACS-1":"10613","Naive-IACS-2":"11604","Naive-IACS-3":"17899","Naive-NT1":"62130","Naive-NT2":"66890","Naive-NT3":"51047"},{"Metabolite":"N-AcetylAspartate(M5)","LT Enza-IACS-1":"17284","LT Enza-IACS-2":"18765","LT Enza-IACS-3":"5723","LT Enza-NT1":"9939","LT Enza-NT2":"25307","LT Enza-NT3":"16488","Naive-IACS-1":"5757","Naive-IACS-2":"6750","Naive-IACS-3":"9607","Naive-NT1":"25507","Naive-NT2":"27374","Naive-NT3":"20963"},{"Metabolite":"Norvaline 260(M0)","LT Enza-IACS-1":"3974877","LT Enza-IACS-2":"3962784","LT Enza-IACS-3":"1827885","LT Enza-NT1":"1703480","LT Enza-NT2":"3679113","LT Enza-NT3":"3189396","Naive-IACS-1":"2534652","Naive-IACS-2":"3159229","Naive-IACS-3":"3991789","Naive-NT1":"2660455","Naive-NT2":"3217247","Naive-NT3":"2659020"},{"Metabolite":"Norvaline 260(M1)","LT Enza-IACS-1":"1092441","LT Enza-IACS-2":"1090942","LT Enza-IACS-3":"490306","LT Enza-NT1":"450636","LT Enza-NT2":"1007972","LT Enza-NT3":"859518","Naive-IACS-1":"681138","Naive-IACS-2":"857863","Naive-IACS-3":"1101177","Naive-NT1":"717103","Naive-NT2":"875987","Naive-NT3":"715646"},{"Metabolite":"Norvaline 260(M2)","LT Enza-IACS-1":"409565","LT Enza-IACS-2":"410397","LT Enza-IACS-3":"183977","LT Enza-NT1":"171562","LT Enza-NT2":"377992","LT Enza-NT3":"325551","Naive-IACS-1":"255240","Naive-IACS-2":"321875","Naive-IACS-3":"411512","Naive-NT1":"267778","Naive-NT2":"327993","Naive-NT3":"267359"},{"Metabolite":"Norvaline 260(M3)","LT Enza-IACS-1":"66754","LT Enza-IACS-2":"67039","LT Enza-IACS-3":"32200","LT Enza-NT1":"29574","LT Enza-NT2":"62204","LT Enza-NT3":"53367","Naive-IACS-1":"42607","Naive-IACS-2":"52818","Naive-IACS-3":"66920","Naive-NT1":"44044","Naive-NT2":"53443","Naive-NT3":"43284"},{"Metabolite":"Norvaline 288(M0)","LT Enza-IACS-1":"3265341","LT Enza-IACS-2":"3270719","LT Enza-IACS-3":"1477085","LT Enza-NT1":"1342339","LT Enza-NT2":"2996590","LT Enza-NT3":"2601310","Naive-IACS-1":"2036278","Naive-IACS-2":"2563583","Naive-IACS-3":"3277615","Naive-NT1":"2135918","Naive-NT2":"2607973","Naive-NT3":"2132606"},{"Metabolite":"Norvaline 288(M1)","LT Enza-IACS-1":"869910","LT Enza-IACS-2":"870560","LT Enza-IACS-3":"381062","LT Enza-NT1":"345706","LT Enza-NT2":"793735","LT Enza-NT3":"683579","Naive-IACS-1":"529887","Naive-IACS-2":"672706","Naive-IACS-3":"872733","Naive-NT1":"557823","Naive-NT2":"686216","Naive-NT3":"555317"},{"Metabolite":"Norvaline 288(M2)","LT Enza-IACS-1":"337419","LT Enza-IACS-2":"336360","LT Enza-IACS-3":"149980","LT Enza-NT1":"135525","LT Enza-NT2":"308021","LT Enza-NT3":"264648","Naive-IACS-1":"206069","Naive-IACS-2":"260697","Naive-IACS-3":"338043","Naive-NT1":"216206","Naive-NT2":"266058","Naive-NT3":"216583"},{"Metabolite":"Norvaline 288(M3)","LT Enza-IACS-1":"53065","LT Enza-IACS-2":"52762","LT Enza-IACS-3":"23816","LT Enza-NT1":"21663","LT Enza-NT2":"48394","LT Enza-NT3":"41673","Naive-IACS-1":"32647","Naive-IACS-2":"41289","Naive-IACS-3":"53551","Naive-NT1":"34010","Naive-NT2":"41445","Naive-NT3":"34314"},{"Metabolite":"Ornithine474(M0)","LT Enza-IACS-1":"5268","LT Enza-IACS-2":"5218","LT Enza-IACS-3":"713","LT Enza-NT1":"573","LT Enza-NT2":"3286","LT Enza-NT3":"1330","Naive-IACS-1":"3545","Naive-IACS-2":"5660","Naive-IACS-3":"9911","Naive-NT1":"1115","Naive-NT2":"2670","Naive-NT3":"1964"},{"Metabolite":"Ornithine474(M1)","LT Enza-IACS-1":"2207","LT Enza-IACS-2":"2120","LT Enza-IACS-3":"315","LT Enza-NT1":"233","LT Enza-NT2":"1289","LT Enza-NT3":"472","Naive-IACS-1":"1523","Naive-IACS-2":"2306","Naive-IACS-3":"4025","Naive-NT1":"451","Naive-NT2":"1000","Naive-NT3":"801"},{"Metabolite":"Ornithine474(M2)","LT Enza-IACS-1":"987","LT Enza-IACS-2":"1007","LT Enza-IACS-3":"151","LT Enza-NT1":"101","LT Enza-NT2":"588","LT Enza-NT3":"239","Naive-IACS-1":"577","Naive-IACS-2":"1086","Naive-IACS-3":"1791","Naive-NT1":"246","Naive-NT2":"496","Naive-NT3":"417"},{"Metabolite":"Ornithine474(M3)","LT Enza-IACS-1":"296","LT Enza-IACS-2":"219","LT Enza-IACS-3":"67","LT Enza-NT1":"118","LT Enza-NT2":"165","LT Enza-NT3":"77","Naive-IACS-1":"150","Naive-IACS-2":"282","Naive-IACS-3":"442","Naive-NT1":"44","Naive-NT2":"107","Naive-NT3":"43"},{"Metabolite":"Ornithine474(M4)","LT Enza-IACS-1":"59","LT Enza-IACS-2":"47","LT Enza-IACS-3":"35","LT Enza-NT1":"72","LT Enza-NT2":"18","LT Enza-NT3":"16","Naive-IACS-1":"45","Naive-IACS-2":"63","Naive-IACS-3":"125","Naive-NT1":"10","Naive-NT2":"13","Naive-NT3":"20"},{"Metabolite":"Ornithine474(M5)","LT Enza-IACS-1":"50","LT Enza-IACS-2":"9","LT Enza-IACS-3":"6","LT Enza-NT1":"20","LT Enza-NT2":"245","LT Enza-NT3":"10","Naive-IACS-1":"14","Naive-IACS-2":"57","Naive-IACS-3":"33","Naive-NT1":"85","Naive-NT2":"20","Naive-NT3":"55"},{"Metabolite":"Ornithine474(M6)","LT Enza-IACS-1":"683","LT Enza-IACS-2":"465","LT Enza-IACS-3":"163","LT Enza-NT1":"28","LT Enza-NT2":"320","LT Enza-NT3":"184","Naive-IACS-1":"9","Naive-IACS-2":"329","Naive-IACS-3":"203","Naive-NT1":"16","Naive-NT2":"34","Naive-NT3":"24"},{"Metabolite":"Pyruvate(M0)","LT Enza-IACS-1":"215579","LT Enza-IACS-2":"206392","LT Enza-IACS-3":"104245","LT Enza-NT1":"124663","LT Enza-NT2":"270083","LT Enza-NT3":"151032","Naive-IACS-1":"169389","Naive-IACS-2":"220542","Naive-IACS-3":"232331","Naive-NT1":"235060","Naive-NT2":"206784","Naive-NT3":"178005"},{"Metabolite":"Pyruvate(M1)","LT Enza-IACS-1":"22902","LT Enza-IACS-2":"34190","LT Enza-IACS-3":"21111","LT Enza-NT1":"13567","LT Enza-NT2":"42867","LT Enza-NT3":"28332","Naive-IACS-1":"17785","Naive-IACS-2":"24570","Naive-IACS-3":"37003","Naive-NT1":"27181","Naive-NT2":"33432","Naive-NT3":"30336"},{"Metabolite":"Pyruvate(M2)","LT Enza-IACS-1":"9067","LT Enza-IACS-2":"11820","LT Enza-IACS-3":"2891","LT Enza-NT1":"9013","LT Enza-NT2":"17306","LT Enza-NT3":"8543","Naive-IACS-1":"15333","Naive-IACS-2":"12102","Naive-IACS-3":"19293","Naive-NT1":"20768","Naive-NT2":"13292","Naive-NT3":"12494"},{"Metabolite":"Pyruvate(M3)","LT Enza-IACS-1":"82914","LT Enza-IACS-2":"93994","LT Enza-IACS-3":"31765","LT Enza-NT1":"31924","LT Enza-NT2":"49440","LT Enza-NT3":"21493","Naive-IACS-1":"139003","Naive-IACS-2":"179940","Naive-IACS-3":"265334","Naive-NT1":"163389","Naive-NT2":"141305","Naive-NT3":"130490"},{"Metabolite":"Pyruvate(M4)","LT Enza-IACS-1":"6822","LT Enza-IACS-2":"6800","LT Enza-IACS-3":"4552","LT Enza-NT1":"2022","LT Enza-NT2":"7206","LT Enza-NT3":"794","Naive-IACS-1":"10849","Naive-IACS-2":"17939","Naive-IACS-3":"21631","Naive-NT1":"13136","Naive-NT2":"11239","Naive-NT3":"11401"},{"Metabolite":"Serine390(M0)","LT Enza-IACS-1":"1323279","LT Enza-IACS-2":"1307215","LT Enza-IACS-3":"540211","LT Enza-NT1":"582180","LT Enza-NT2":"1350869","LT Enza-NT3":"805170","Naive-IACS-1":"850988","Naive-IACS-2":"1090835","Naive-IACS-3":"1425068","Naive-NT1":"1038591","Naive-NT2":"1160357","Naive-NT3":"968192"},{"Metabolite":"Serine390(M1)","LT Enza-IACS-1":"557195","LT Enza-IACS-2":"553634","LT Enza-IACS-3":"226446","LT Enza-NT1":"231654","LT Enza-NT2":"542200","LT Enza-NT3":"321127","Naive-IACS-1":"375476","Naive-IACS-2":"483343","Naive-IACS-3":"635340","Naive-NT1":"454989","Naive-NT2":"508105","Naive-NT3":"419082"},{"Metabolite":"Serine390(M2)","LT Enza-IACS-1":"312322","LT Enza-IACS-2":"312737","LT Enza-IACS-3":"126802","LT Enza-NT1":"123011","LT Enza-NT2":"289015","LT Enza-NT3":"170704","Naive-IACS-1":"221166","Naive-IACS-2":"285704","Naive-IACS-3":"375925","Naive-NT1":"261392","Naive-NT2":"292918","Naive-NT3":"240036"},{"Metabolite":"Serine390(M3)","LT Enza-IACS-1":"125924","LT Enza-IACS-2":"110499","LT Enza-IACS-3":"44418","LT Enza-NT1":"60736","LT Enza-NT2":"141510","LT Enza-NT3":"83850","Naive-IACS-1":"111519","Naive-IACS-2":"139268","Naive-IACS-3":"182578","Naive-NT1":"254294","Naive-NT2":"285846","Naive-NT3":"232663"},{"Metabolite":"Serine390(M4)","LT Enza-IACS-1":"37680","LT Enza-IACS-2":"32626","LT Enza-IACS-3":"12958","LT Enza-NT1":"17678","LT Enza-NT2":"41457","LT Enza-NT3":"24514","Naive-IACS-1":"34010","Naive-IACS-2":"42282","Naive-IACS-3":"55840","Naive-NT1":"77665","Naive-NT2":"87828","Naive-NT3":"70969"},{"Metabolite":"Succinate(M0)","LT Enza-IACS-1":"115272","LT Enza-IACS-2":"1075985","LT Enza-IACS-3":"59855","LT Enza-NT1":"56283","LT Enza-NT2":"131426","LT Enza-NT3":"72058","Naive-IACS-1":"90905","Naive-IACS-2":"87326","Naive-IACS-3":"118003","Naive-NT1":"129255","Naive-NT2":"130210","Naive-NT3":"100195"},{"Metabolite":"Succinate(M1)","LT Enza-IACS-1":"27882","LT Enza-IACS-2":"260454","LT Enza-IACS-3":"14084","LT Enza-NT1":"15538","LT Enza-NT2":"37248","LT Enza-NT3":"20714","Naive-IACS-1":"21454","Naive-IACS-2":"20586","Naive-IACS-3":"26771","Naive-NT1":"33209","Naive-NT2":"34919","Naive-NT3":"26885"},{"Metabolite":"Succinate(M2)","LT Enza-IACS-1":"14959","LT Enza-IACS-2":"112383","LT Enza-IACS-3":"6347","LT Enza-NT1":"10138","LT Enza-NT2":"25455","LT Enza-NT3":"14760","Naive-IACS-1":"9689","Naive-IACS-2":"9506","Naive-IACS-3":"12890","Naive-NT1":"26674","Naive-NT2":"29434","Naive-NT3":"21770"},{"Metabolite":"Succinate(M3)","LT Enza-IACS-1":"3367","LT Enza-IACS-2":"17855","LT Enza-IACS-3":"1155","LT Enza-NT1":"3050","LT Enza-NT2":"7800","LT Enza-NT3":"4698","Naive-IACS-1":"1913","Naive-IACS-2":"1935","Naive-IACS-3":"2577","Naive-NT1":"9283","Naive-NT2":"10123","Naive-NT3":"7727"},{"Metabolite":"Succinate(M4)","LT Enza-IACS-1":"1491","LT Enza-IACS-2":"4180","LT Enza-IACS-3":"680","LT Enza-NT1":"1697","LT Enza-NT2":"3695","LT Enza-NT3":"2352","Naive-IACS-1":"1055","Naive-IACS-2":"1189","Naive-IACS-3":"1368","Naive-NT1":"4014","Naive-NT2":"4746","Naive-NT3":"3793"},{"Metabolite":"Succinate(M5)","LT Enza-IACS-1":"412","LT Enza-IACS-2":"662","LT Enza-IACS-3":"248","LT Enza-NT1":"345","LT Enza-NT2":"932","LT Enza-NT3":"630","Naive-IACS-1":"263","Naive-IACS-2":"267","Naive-IACS-3":"216","Naive-NT1":"932","Naive-NT2":"1115","Naive-NT3":"1100"},{"Metabolite":"Threonine404(M0)","LT Enza-IACS-1":"115134","LT Enza-IACS-2":"128562","LT Enza-IACS-3":"28728","LT Enza-NT1":"29033","LT Enza-NT2":"109256","LT Enza-NT3":"39902","Naive-IACS-1":"68795","Naive-IACS-2":"125115","Naive-IACS-3":"149722","Naive-NT1":"111856","Naive-NT2":"118510","Naive-NT3":"99986"},{"Metabolite":"Threonine404(M1)","LT Enza-IACS-1":"40278","LT Enza-IACS-2":"45002","LT Enza-IACS-3":"10035","LT Enza-NT1":"10167","LT Enza-NT2":"38341","LT Enza-NT3":"14117","Naive-IACS-1":"23891","Naive-IACS-2":"43292","Naive-IACS-3":"52362","Naive-NT1":"39666","Naive-NT2":"41514","Naive-NT3":"35129"},{"Metabolite":"Threonine404(M2)","LT Enza-IACS-1":"20842","LT Enza-IACS-2":"22999","LT Enza-IACS-3":"5269","LT Enza-NT1":"5266","LT Enza-NT2":"19398","LT Enza-NT3":"7243","Naive-IACS-1":"12092","Naive-IACS-2":"21085","Naive-IACS-3":"25146","Naive-NT1":"18468","Naive-NT2":"20061","Naive-NT3":"16676"},{"Metabolite":"Threonine404(M3)","LT Enza-IACS-1":"5043","LT Enza-IACS-2":"5513","LT Enza-IACS-3":"1380","LT Enza-NT1":"1073","LT Enza-NT2":"4672","LT Enza-NT3":"1764","Naive-IACS-1":"3044","Naive-IACS-2":"4901","Naive-IACS-3":"6083","Naive-NT1":"4292","Naive-NT2":"4659","Naive-NT3":"3943"},{"Metabolite":"Threonine404(M4)","LT Enza-IACS-1":"1310","LT Enza-IACS-2":"1580","LT Enza-IACS-3":"290","LT Enza-NT1":"243","LT Enza-NT2":"1030","LT Enza-NT3":"371","Naive-IACS-1":"732","Naive-IACS-2":"1280","Naive-IACS-3":"1455","Naive-NT1":"965","Naive-NT2":"1233","Naive-NT3":"930"},{"Metabolite":"Threonine404(M5)","LT Enza-IACS-1":"289","LT Enza-IACS-2":"236","LT Enza-IACS-3":"91","LT Enza-NT1":"52","LT Enza-NT2":"207","LT Enza-NT3":"130","Naive-IACS-1":"141","Naive-IACS-2":"237","Naive-IACS-3":"204","Naive-NT1":"272","Naive-NT2":"179","Naive-NT3":"172"},{"Metabolite":"Urea(M0)","LT Enza-IACS-1":"543176","LT Enza-IACS-2":"461669","LT Enza-IACS-3":"465","LT Enza-NT1":"531","LT Enza-NT2":"1048292","LT Enza-NT3":"273828","Naive-IACS-1":"74405","Naive-IACS-2":"422136","Naive-IACS-3":"516481","Naive-NT1":"346239","Naive-NT2":"403927","Naive-NT3":"257679"},{"Metabolite":"Urea(M1)","LT Enza-IACS-1":"111405","LT Enza-IACS-2":"32042","LT Enza-IACS-3":"558","LT Enza-NT1":"620","LT Enza-NT2":"217563","LT Enza-NT3":"56156","Naive-IACS-1":"40523","Naive-IACS-2":"86696","Naive-IACS-3":"106745","Naive-NT1":"71630","Naive-NT2":"30523","Naive-NT3":"53855"},{"Metabolite":"Valine288(M0)","LT Enza-IACS-1":"91415","LT Enza-IACS-2":"93209","LT Enza-IACS-3":"33420","LT Enza-NT1":"27370","LT Enza-NT2":"82301","LT Enza-NT3":"51486","Naive-IACS-1":"56761","Naive-IACS-2":"76732","Naive-IACS-3":"114600","Naive-NT1":"62324","Naive-NT2":"78346","Naive-NT3":"62725"},{"Metabolite":"Valine288(M1)","LT Enza-IACS-1":"22477","LT Enza-IACS-2":"23200","LT Enza-IACS-3":"8199","LT Enza-NT1":"6872","LT Enza-NT2":"20577","LT Enza-NT3":"12462","Naive-IACS-1":"14013","Naive-IACS-2":"18581","Naive-IACS-3":"28361","Naive-NT1":"15215","Naive-NT2":"19250","Naive-NT3":"15120"},{"Metabolite":"Valine288(M2)","LT Enza-IACS-1":"9038","LT Enza-IACS-2":"8882","LT Enza-IACS-3":"3189","LT Enza-NT1":"2751","LT Enza-NT2":"7995","LT Enza-NT3":"4994","Naive-IACS-1":"5676","Naive-IACS-2":"7468","Naive-IACS-3":"11073","Naive-NT1":"6212","Naive-NT2":"7472","Naive-NT3":"6058"},{"Metabolite":"Valine288(M3)","LT Enza-IACS-1":"1480","LT Enza-IACS-2":"1459","LT Enza-IACS-3":"502","LT Enza-NT1":"459","LT Enza-NT2":"1324","LT Enza-NT3":"821","Naive-IACS-1":"875","Naive-IACS-2":"1121","Naive-IACS-3":"1667","Naive-NT1":"965","Naive-NT2":"1224","Naive-NT3":"1062"},{"Metabolite":"Valine288(M4)","LT Enza-IACS-1":"198","LT Enza-IACS-2":"194","LT Enza-IACS-3":"82","LT Enza-NT1":"79","LT Enza-NT2":"205","LT Enza-NT3":"154","Naive-IACS-1":"162","Naive-IACS-2":"129","Naive-IACS-3":"303","Naive-NT1":"119","Naive-NT2":"195","Naive-NT3":"196"},{"Metabolite":"Valine288(M5)","LT Enza-IACS-1":"525","LT Enza-IACS-2":"558","LT Enza-IACS-3":"404","LT Enza-NT1":"434","LT Enza-NT2":"585","LT Enza-NT3":"451","Naive-IACS-1":"550","Naive-IACS-2":"464","Naive-IACS-3":"571","Naive-NT1":"455","Naive-NT2":"547","Naive-NT3":"493"},{"Metabolite":"Valine288(M6)","LT Enza-IACS-1":"133","LT Enza-IACS-2":"171","LT Enza-IACS-3":"13","LT Enza-NT1":"","LT Enza-NT2":"10","LT Enza-NT3":"19","Naive-IACS-1":"27","Naive-IACS-2":"98","Naive-IACS-3":"124","Naive-NT1":"16","Naive-NT2":"103","Naive-NT3":"171"}],

"Metabolites":[{"metabolite_name":"a-Ketoglutarate(M0)"},{"metabolite_name":"a-Ketoglutarate(M1)"},{"metabolite_name":"a-Ketoglutarate(M2)"},{"metabolite_name":"a-Ketoglutarate(M3)"},{"metabolite_name":"a-Ketoglutarate(M4)"},{"metabolite_name":"a-Ketoglutarate(M5)"},{"metabolite_name":"a-Ketoglutarate(M6)"},{"metabolite_name":"Alanine260(M0)"},{"metabolite_name":"Alanine260(M1)"},{"metabolite_name":"Alanine260(M2)"},{"metabolite_name":"Alanine260(M3)"},{"metabolite_name":"Alanine260(M4)"},{"metabolite_name":"Asparagine(M0)"},{"metabolite_name":"Asparagine(M1)"},{"metabolite_name":"Asparagine(M2)"},{"metabolite_name":"Asparagine(M3)"},{"metabolite_name":"Asparagine(M4)"},{"metabolite_name":"Asparagine(M5)"},{"metabolite_name":"Aspartate418(M0)"},{"metabolite_name":"Aspartate418(M1)"},{"metabolite_name":"Aspartate418(M2)"},{"metabolite_name":"Aspartate418(M3)"},{"metabolite_name":"Aspartate418(M4)"},{"metabolite_name":"Aspartate418(M5)"},{"metabolite_name":"Citrate459(M0)"},{"metabolite_name":"Citrate459(M1)"},{"metabolite_name":"Citrate459(M2)"},{"metabolite_name":"Citrate459(M3)"},{"metabolite_name":"Citrate459(M4)"},{"metabolite_name":"Citrate459(M5)"},{"metabolite_name":"Citrate459(M6)"},{"metabolite_name":"Citrate459(M7)"},{"metabolite_name":"Citrate591(M0)"},{"metabolite_name":"Citrate591(M1)"},{"metabolite_name":"Citrate591(M2)"},{"metabolite_name":"Citrate591(M3)"},{"metabolite_name":"Citrate591(M4)"},{"metabolite_name":"Citrate591(M5)"},{"metabolite_name":"Citrate591(M6)"},{"metabolite_name":"Citrate591(M7)"},{"metabolite_name":"Cysteine(M0)"},{"metabolite_name":"Cysteine(M1)"},{"metabolite_name":"Cysteine(M2)"},{"metabolite_name":"Cysteine(M3)"},{"metabolite_name":"Cysteine(M4)"},{"metabolite_name":"Fumarate(M0)"},{"metabolite_name":"Fumarate(M1)"},{"metabolite_name":"Fumarate(M2)"},{"metabolite_name":"Fumarate(M3)"},{"metabolite_name":"Fumarate(M4)"},{"metabolite_name":"Fumarate(M5)"},{"metabolite_name":"GABA(M0)"},{"metabolite_name":"GABA(M1)"},{"metabolite_name":"GABA(M2)"},{"metabolite_name":"GABA(M3)"},{"metabolite_name":"GABA(M4)"},{"metabolite_name":"GABA(M5)"},{"metabolite_name":"Glutamate432(M0)"},{"metabolite_name":"Glutamate432(M1)"},{"metabolite_name":"Glutamate432(M2)"},{"metabolite_name":"Glutamate432(M3)"},{"metabolite_name":"Glutamate432(M4)"},{"metabolite_name":"Glutamate432(M5)"},{"metabolite_name":"Glutamate432(M6)"},{"metabolite_name":"Isoleucine274(M0)"},{"metabolite_name":"Isoleucine274(M1)"},{"metabolite_name":"Isoleucine274(M2)"},{"metabolite_name":"Isoleucine274(M3)"},{"metabolite_name":"Isoleucine274(M4)"},{"metabolite_name":"Isoleucine274(M5)"},{"metabolite_name":"Isoleucine274(M6)"},{"metabolite_name":"Isoleucine274(M7)"},{"metabolite_name":"Itaconate(M0)"},{"metabolite_name":"Itaconate(M1)"},{"metabolite_name":"Itaconate(M2)"},{"metabolite_name":"Itaconate(M3)"},{"metabolite_name":"Itaconate(M4)"},{"metabolite_name":"Itaconate(M5)"},{"metabolite_name":"Itaconate(M6)"},{"metabolite_name":"KIC (M0)"},{"metabolite_name":"KIC (M1)"},{"metabolite_name":"KIC (M2)"},{"metabolite_name":"KIC (M3)"},{"metabolite_name":"KIC (M4)"},{"metabolite_name":"KIC (M5)"},{"metabolite_name":"KIC (M6)"},{"metabolite_name":"KIC (M7)"},{"metabolite_name":"KIV (M0)"},{"metabolite_name":"KMV(M0)"},{"metabolite_name":"Lactate261(M0)"},{"metabolite_name":"Lactate261(M1)"},{"metabolite_name":"Lactate261(M2)"},{"metabolite_name":"Lactate261(M3)"},{"metabolite_name":"Lactate261(M4)"},{"metabolite_name":"Leucine 274 (M0)"},{"metabolite_name":"Leucine 274 (M1)"},{"metabolite_name":"Leucine 274 (M2)"},{"metabolite_name":"Leucine 274 (M3)"},{"metabolite_name":"Leucine 274 (M4)"},{"metabolite_name":"Leucine 274 (M5)"},{"metabolite_name":"Leucine 274 (M6)"},{"metabolite_name":"Malate(M0)"},{"metabolite_name":"Malate(M1)"},{"metabolite_name":"Malate(M2)"},{"metabolite_name":"Malate(M3)"},{"metabolite_name":"Malate(M4)"},{"metabolite_name":"Malate(M5)"},{"metabolite_name":"Methionine320(M0)"},{"metabolite_name":"Methionine320(M1)"},{"metabolite_name":"Methionine320(M2)"},{"metabolite_name":"Methionine320(M3)"},{"metabolite_name":"Methionine320(M4)"},{"metabolite_name":"Methionine320(M5)"},{"metabolite_name":"Methionine320(M6)"},{"metabolite_name":"N-AcetylAspartate(M0)"},{"metabolite_name":"N-AcetylAspartate(M1)"},{"metabolite_name":"N-AcetylAspartate(M2)"},{"metabolite_name":"N-AcetylAspartate(M3)"},{"metabolite_name":"N-AcetylAspartate(M4)"},{"metabolite_name":"N-AcetylAspartate(M5)"},{"metabolite_name":"Norvaline 260(M0)"},{"metabolite_name":"Norvaline 260(M1)"},{"metabolite_name":"Norvaline 260(M2)"},{"metabolite_name":"Norvaline 260(M3)"},{"metabolite_name":"Norvaline 288(M0)"},{"metabolite_name":"Norvaline 288(M1)"},{"metabolite_name":"Norvaline 288(M2)"},{"metabolite_name":"Norvaline 288(M3)"},{"metabolite_name":"Ornithine474(M0)"},{"metabolite_name":"Ornithine474(M1)"},{"metabolite_name":"Ornithine474(M2)"},{"metabolite_name":"Ornithine474(M3)"},{"metabolite_name":"Ornithine474(M4)"},{"metabolite_name":"Ornithine474(M5)"},{"metabolite_name":"Ornithine474(M6)"},{"metabolite_name":"Pyruvate(M0)"},{"metabolite_name":"Pyruvate(M1)"},{"metabolite_name":"Pyruvate(M2)"},{"metabolite_name":"Pyruvate(M3)"},{"metabolite_name":"Pyruvate(M4)"},{"metabolite_name":"Serine390(M0)"},{"metabolite_name":"Serine390(M1)"},{"metabolite_name":"Serine390(M2)"},{"metabolite_name":"Serine390(M3)"},{"metabolite_name":"Serine390(M4)"},{"metabolite_name":"Succinate(M0)"},{"metabolite_name":"Succinate(M1)"},{"metabolite_name":"Succinate(M2)"},{"metabolite_name":"Succinate(M3)"},{"metabolite_name":"Succinate(M4)"},{"metabolite_name":"Succinate(M5)"},{"metabolite_name":"Threonine404(M0)"},{"metabolite_name":"Threonine404(M1)"},{"metabolite_name":"Threonine404(M2)"},{"metabolite_name":"Threonine404(M3)"},{"metabolite_name":"Threonine404(M4)"},{"metabolite_name":"Threonine404(M5)"},{"metabolite_name":"Urea(M0)"},{"metabolite_name":"Urea(M1)"},{"metabolite_name":"Valine288(M0)"},{"metabolite_name":"Valine288(M1)"},{"metabolite_name":"Valine288(M2)"},{"metabolite_name":"Valine288(M3)"},{"metabolite_name":"Valine288(M4)"},{"metabolite_name":"Valine288(M5)"},{"metabolite_name":"Valine288(M6)"}]
}

}